CN112791299A

CN112791299A - Anorectal disease postoperative recovery auxiliary material

Info

Publication number: CN112791299A
Application number: CN202110403705.8A
Authority: CN
Inventors: 许媛慧
Original assignee: Beijing Xinkangyan Pharmaceutical Technology Co ltd; Shandong Qianfoshan Hospital
Current assignee: Shandong Qianfoshan Hospital
Priority date: 2021-04-15
Filing date: 2021-04-15
Publication date: 2021-05-14
Anticipated expiration: 2041-04-15
Also published as: CN112791299B

Abstract

The invention belongs to the field of medical materials, and particularly relates to an anorectal postoperative recovery auxiliary material which is a cylinder with a round head at one end, and the anorectal postoperative recovery auxiliary material sequentially comprises an inner core, a water-absorbing expansion layer and a medicine layer from inside to outside, wherein one end of the round head of the inner core is connected with the water-absorbing expansion layer, and a lubricating layer is arranged on the unconnected part between the inner core and the water-absorbing expansion layer. The anorectal disease postoperative recovery auxiliary material provided by the invention is used for postoperative recovery treatment of anorectal disease patients, is simple and convenient to use, and does not rub and pull an operation wound in the process of placement and taking out; the wound surface can be kept dry, the healing of the operation wound is promoted, the postoperative recovery period is shortened, and the postoperative pain of a patient is relieved; and the problems of granulation overgrowth and scar hyperplasia of the wound surface can be effectively avoided, so that the wound surface can be kept flat after recovery.

Description

Anorectal disease postoperative recovery auxiliary material

Technical Field

The invention belongs to the field of medical materials, and particularly relates to an anorectal postoperative recovery auxiliary material.

Background

The anorectal diseases are frequently encountered clinically, and the incidence rate of the hepatic portal and rectal diseases exceeds 50 percent according to statistics of related data. At present, the treatment methods of the anorectal diseases mainly comprise internal medicine, external medicine and operation treatment. Wherein, the medicine has slow curative effect by oral administration, and is easy to be polluted or damaged again in the recovery process to generate other diseases; the medicine for external use can not fully play a role, has a slight curative effect, and has frequent dressing change times and low patient compliance. Moreover, the two methods can only treat patients with mild disease and hardly have obvious curative effect on patients with severe disease.

The surgical treatment can fundamentally solve the focus, but the postoperative wound surface of the anorectal disease is mostly provided with bacteria and has open wounds without suture, and the wound surface repair is a complex biological process expressed by the body responding to skin injury and mainly comprises a local inflammatory reaction stage, a cell proliferation and differentiation stage, a granulation tissue formation stage and a tissue reconstruction stage, wherein angiogenesis in the wound surface gradually forms new capillaries through proliferation of vascular endothelial cells, the granulation tissue and fibroblasts, endothelial cells, new blood vessels and the like form granulation tissue together to fill wound cavities or tissue cracks, and original blood clots, necrotic tissue and the like can be decomposed by enzyme, and leukocytes phagocytize, absorb or discharge from the wound. The fibroblasts synthesize procollagen and amino polysaccharide, collagen fibers in granulation tissues are gradually increased, the hardness and the tension of the collagen fibers are enhanced, the granulation tissues are converted into fibrous tissues to be grafted among broken tissues, and meanwhile, epithelial cells are proliferated to realize wound healing under the combined action. Therefore, the recovery time of the operation wound after the anorectal disease operation is long, and the nursing is also troublesome. The postoperative wound surface has symptoms of bleeding, liquid seepage, pain, pruritus, burning heat and the like, and brings pain to patients; and the problems of granulation tissue hyperplasia of the wound surface, pseudo healing of the wound surface, uneven healing surface, scar hyperplasia and the like are easy to occur. At present, the problems of excessive granulation, scar hyperplasia, uneven wound surface and the like after the operation of a patient are solved by adopting conventional sitting compression therapy such as cotton padding compression and the like, but the effect is not ideal, so that a lot of patients still need to solve the granulation or scar hyperplasia tissues with local over-protrusion through an operation means again after the operation recovery.

Disclosure of Invention

The invention aims to overcome the defects in the prior art and provide a postoperative recovery article for anorectal diseases, which has the effects of promoting wound healing, relieving pain of patients and preventing overgrowth of granulation on wound surfaces and scar hyperplasia.

In order to achieve the purpose, the invention adopts the following technical scheme:

the utility model provides an anorectal disease postoperative resumes auxiliary material, the material is the cylinder that one end is the button head, the material includes inner core, water swelling layer and medicine layer from inside to outside in proper order, the one end of the button head of inner core with the water swelling layer is connected, the inner core with the part of not connecting still is provided with the lubricating layer between the water swelling layer.

The anorectal disease postoperative recovery auxiliary material provided by the invention can be applied to an operation wound of an anorectal disease patient, and simultaneously plays a role in applying medicine to the wound and providing proper pressure for the wound. When the material provided by the invention is used, the round end of the material is placed into the anorectum of a patient facing inwards. The patient may generally begin applying the materials provided herein after the surgical incision has successfully stopped bleeding until the surgical incision is substantially restored. Wherein the medicament layer may act to promote recovery of the operative wound and/or to reduce pain at the wound site. On one hand, the water absorption expansion layer can absorb the exudate of the operation wound, keep the wound position dry and be beneficial to the recovery of the wound; on the other hand, the volume of the wound exudate absorbing bag is increased, a certain compression force is applied to the operation wound, and the problems of granulation overgrowth, scar hyperplasia and the like on the wound surface can be effectively avoided. The inner core is connected with the water-absorbing expansion layer at round head one end, and the unconnected part between the inner core and the water-absorbing expansion layer is provided with the lubricating layer, so that the postoperative recovery auxiliary material for the anorectal disease with the enlarged volume after use can be taken out from the anorectum without influencing the operation wound. When the anorectal disease postoperative recovery auxiliary material is taken out, the non-round-head end of the inner core is grasped and pulled outwards, the water absorption expansion layer is driven to deform and fold in the direction from the round-head end to the inner core in the process of moving outwards by the inner core, and the water absorption expansion layer is gradually separated from the inner wall of the anorectal from the innermost end until the water absorption expansion layer is completely separated from the anorectal. The whole process of taking out the anorectal disease postoperative recovery auxiliary material is simple and convenient to operate, the wound cannot be pulled by friction, pain of a patient is avoided, and recovery of the patient is facilitated. In order to further facilitate the operation, a pull rope, a pull buckle and other structures can be arranged at the non-round end of the inner core.

In the invention, the postoperative recovery auxiliary material for the anorectal disease is designed into a cylinder with a round head at one end, so that the material can be conveniently placed into the anorectal from the anus of a patient. In practical application, the cylinder can also be designed into materials with different height specifications, so that anorectal patients can select materials with proper height according to the specific position of the operation wound. The diameter of the material before use is such that it is convenient for the patient to place in the anorectum and not to easily fall out, and it is not easy to squeeze and tear the surgical wound during the placement of the material.

In the invention, the function of the medicine layer at least comprises at least one of promoting the recovery of the operation wound and relieving the pain feeling at the position of the operation wound, and the medicine layer can be prepared by adopting external paste or gel of at least one of traditional Chinese medicine, Chinese patent medicine, western medicine or mixture thereof.

The lubricating layer can be prepared by common lubricant, so that the adhesion of the inner core and the water-absorbing expansion layer can be avoided, and the resistance when the inner core and the water-absorbing expansion layer move relatively is reduced.

Furthermore, a through hole is formed in the material along the central axis direction of the cylinder. Is beneficial to the patient to discharge the gas in the intestinal tract.

Furthermore, the material also comprises a bottom patch connected with the non-round-head end of the inner core, wherein the bottom patch is provided with a lubricating layer, a water-swelling layer and a medicine layer which are sequentially arranged on one side of the cylinder, and the through hole penetrates through the bottom patch.

The anorectal disease postoperative recovery auxiliary material provided by the invention is provided with the bottom paste, so that the operation wound at the periphery of an anus can be conveniently treated by medicines and a certain compression force is applied, and meanwhile, the material is more conveniently placed into the anus and taken out by a patient or medical personnel, and the anorectal disease postoperative recovery auxiliary material is convenient to use.

Furthermore, a medicine permeable membrane is arranged on one side of the medicine layer, which is far away from the water-absorbing expansion layer, and the medicine permeable membrane is an elastic membrane provided with a plurality of medicine permeable holes.

In the invention, the elastic medicine permeable membrane is arranged on the outer side of the medicine layer, so that the medicine layer can be protected and the medicine effect of the medicine layer is not influenced.

Further, the medicine permeable membrane is an anti-adhesion membrane.

In the invention, the anti-adhesion film is selected as the drug-permeable film, so that secondary wound caused by adhesion of the drug-permeable film and the surgical wound surface can be avoided, and the recovery of the wound surface is facilitated.

Furthermore, one side of the bottom sticker far away from the cylinder is provided with an adhesive layer. The anorectal disease postoperative recovery auxiliary material is convenient to fix on underpants of a patient for use.

Furthermore, release paper is arranged on one side, far away from the bottom sticker, of the self-adhesive layer.

Further, the water absorption expansion layer is prepared from a flexible high polymer water absorption material, the water absorption expansion rate of the high polymer water absorption material is 100-200%, and the thickness of the water absorption expansion layer is 2-4 mm.

In the present invention, the water-swelling layer may be made of a flexible water-swelling polymer material that is commonly used in the medical field, such as one or more of cellulose-based, polyvinyl acetate-based, polyoxyethylene-based, starch-grafted acrylate-based, and the like.

The high molecular water-absorbing material with the water-absorbing expansion rate of 100-200% is selected, the thickness of the water-absorbing expansion layer is set to be 2-4mm, and the volume change condition of the water-absorbing expansion layer before and after water absorption is reasonable. The material with proper size can be prepared, the material is not easy to fall off from the anorectum when being just put into the anorectum, and the excessive pressure brought to the operation wound by the overlarge volume change of the material after water absorption expansion, the influence on the wound recovery and the pain brought to a patient can be avoided.

Further, the medicine for preparing the medicine layer comprises the following components in parts by weight:

mupirocin 1-2

12-20 parts of sweetgum resin

Olibanum 5-8

Myrrha 5-8

15-30 of traditional Chinese medicine extract

30-40 parts of polyethylene glycol.

Wherein:

sweetgum resin: is dried resin of Liquidambar formosana Hance of Hamamelidaceae, and has effects of promoting blood circulation, relieving pain, removing toxic substance, promoting granulation, and cooling blood.

Frankincense: is oleoresin exuded from trunk and bark wounds of boswellia serrata, and boswellia serrata of boswellia of Burseraceae, and has effects in promoting blood circulation and relieving pain.

Myrrh: is oleoresin exuded from trunk and bark of Commiphora myrrha of Commiphora of Burseraceae, has effects of removing blood stasis and relieving pain, and can be used for detumescence and promoting granulation.

Further, the traditional Chinese medicine extract is mainly prepared from the following components in parts by weight:

10-30 of salvia miltiorrhiza

10-20 parts of fructus forsythiae

Ligusticum wallichii 8-15

Oldenlandia 8-12

Pseudobulbus Cremastrae Seu pleiones 5-8

5-8 of lithospermum

Peach kernel 3-8

Coptis root 3-5

And 2-5 parts of oriental wormwood.

In the invention, the medicine for preparing the medicine layer adopts a mode of matching mupirocin and a plurality of traditional Chinese medicine components. The traditional Chinese medicine components have good effects of clearing heat and removing toxicity, removing blood stasis and resolving masses, and relieving swelling and pain, and can play a better role in promoting the recovery of an operation wound and relieving the pain of a patient simultaneously by the synergistic effect with mupirocin, so that the pain of the patient and the itching in the middle and later recovery periods can be obviously relieved.

In the invention, the traditional Chinese medicine extract prepared from the traditional Chinese medicine components of salvia miltiorrhiza, fructus forsythiae, ligusticum wallichii, oldenlandia diffusa, edible tulip, lithospermum, peach kernel, coptis chinensis and oriental wormwood is applied to the medicine layer, so that the medicine effect can be improved, and the adverse effect of impurities on wounds can be avoided.

Wherein:

red sage root: is dried root and rhizome of Salvia miltiorrhiza Bunge of Labiatae, and has effects of removing blood stasis, relieving pain, promoting blood circulation, dredging channels, clearing heart fire, and relieving restlessness.

Fructus forsythiae: is dried fruit of Forsythia suspensa of Oleaceae, and has effects of clearing away heat and toxic materials, relieving swelling, and resolving hard mass.

Ligusticum wallichii: is dried rhizome of Umbelliferae plant rhizoma Ligustici Chuanxiong, and has effects of promoting blood circulation, activating qi-flowing, dispelling pathogenic wind and relieving pain.

Herba Hedyotidis Diffusae: is whole plant of herba Hedyotidis Diffusae of genus Erodiaceae, and has effects of clearing away heat and toxic materials, promoting urination, relieving swelling, promoting blood circulation, and relieving pain.

And (3) edible tulip: is dry pseudobulb of Rhododendron simsii planch, Pleiones bulbifera or Pleiones yunnanensis of Orchidaceae, and has effects of clearing away heat and toxic materials, eliminating phlegm and resolving hard mass.

Lithospermum: is the dry root of arnebia euchroma (Royle) Johnst, Lithospermum erythrorhizon or Lithospermum erythrorhizon of Boraginaceae, and has effects of cooling blood, promoting blood circulation, removing toxic substance and promoting eruption.

Peach kernel: is dried mature seed of Prunus persica or Prunus davidiana of Rosaceae, and has effects of promoting blood circulation, removing blood stasis, and loosening bowel to relieve constipation.

Coptis chinensis: is dried rhizome of Coptidis rhizoma, Coptidis rhizoma or Coptidis rhizoma of Ranunculaceae, and has effects of clearing heat, eliminating dampness, purging pathogenic fire and removing toxic substance.

Herba artemisiae scopariae: is dry aerial part of Artemisia scoparia or Artemisia capillaris Thunb of Compositae, and has effects of clearing away damp-heat and eliminating jaundice.

Further, the preparation method of the medicament for preparing the medicament layer comprises the following steps:

pulverizing each component for preparing Chinese medicinal extract to obtain Chinese medicinal powder, mixing with water at a weight ratio of 1:10-20, soaking at 70-80 deg.C for 10-15 hr, and leaching at 70-80 deg.C for 2-5 hr under stirring to obtain first leaching solution; mixing the Chinese medicinal extraction residue with anhydrous ethanol at a weight ratio of 1:5-10, soaking at 50-60 deg.C for 5-12 hr, and stirring at 50-60 deg.C for 2-5 hr to obtain second extractive solution; mixing the first leaching solution and the second leaching solution uniformly, removing ethanol, standing, filtering to obtain clear solution, and concentrating the clear solution to relative density of 1.1 at 70 deg.C to obtain Chinese medicinal extract;

respectively grinding mupirocin, resina Liquidambaris, Olibanum and Myrrha into 200 mesh powder, and mixing to obtain mixed powder;

adding the mixed powder into the Chinese medicinal extract, mixing, and grinding at 30-50 deg.C for 0.5-1 h; adding polyethylene glycol, and grinding at 30-50 deg.C for 1-2h to obtain the medicine for preparing the medicine layer.

In the method for preparing the traditional Chinese medicine extract, water and absolute ethyl alcohol are adopted for extraction twice in sequence, so that the content of effective medicinal ingredients in the traditional Chinese medicine extract can be improved.

According to the invention, the traditional Chinese medicine extracts of the traditional Chinese medicine components including the salvia miltiorrhiza, the forsythia, the ligusticum wallichii, the oldenlandia diffusa, the edible tulip, the lithospermum, the peach kernel, the coptis chinensis and the oriental wormwood are prepared to be applied to the medicine layer, the sweetgum resin, the frankincense and the myrrh are directly ground and pulverized to be applied to the medicine layer, different application methods are selected according to the characteristics of various traditional Chinese medicine components, so that the medicine effects of the components can be well exerted, and the treatment effect of the medicine layer is better.

In the actual preparation process, the thickness of the traditional Chinese medicine powder needs to consider two factors of being beneficial to operation and being convenient for the dissolution of effective medicinal ingredients, and the traditional Chinese medicine powder can be generally crushed into powder of 60-100 meshes.

The ethanol removal operation may be carried out by a conventional ethanol removal method such as distillation.

The beneficial effects of the invention include:

the anorectal disease postoperative recovery auxiliary material provided by the invention is applied to postoperative recovery treatment of anorectal disease patients, is simple and convenient to use, and does not rub and pull an operation wound in the process of placement and taking out; the wound surface can be kept dry, the healing of the operation wound is promoted, the postoperative recovery period is shortened, and the postoperative pain of a patient is relieved; and the problems of granulation overgrowth and scar hyperplasia of the wound surface can be effectively avoided, so that the wound surface can be kept flat after recovery.

Drawings

Fig. 1 is a schematic sectional view of the anorectal disease postoperative recovery aid of example 1.

Fig. 2 is a schematic sectional view of the anorectal disease postoperative recovery aid of example 2.

Fig. 3 is a schematic sectional view of the anorectal disease postoperative recovery aid of example 3.

Wherein, the plaster comprises 1-an inner core, 2-a water-absorbing expansion layer, 3-a medicine layer, 4-a bottom patch, 5-a through hole, 6-a medicine permeable membrane, 7-a non-drying glue layer, 8-release paper and 9-a lubricating layer.

Detailed Description

In order to make the technical problems, technical solutions and advantageous effects to be solved by the present invention more apparent, the present invention is further described in detail below with reference to specific embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the present patent and do not limit the scope of the invention in any way.

Unless defined otherwise, technical terms used in the following examples have the same meanings as commonly understood by one of ordinary skill in the art to which the present invention belongs. The reagents used in the following examples, unless otherwise specified, are all conventional biochemical reagents; the raw materials, instruments, equipment and the like used in the following examples are either commercially available or available by existing methods; the dosage of the reagent is the dosage of the reagent in the conventional experiment operation if no special description exists; the experimental methods are conventional methods unless otherwise specified.

Example 1

An anorectal disease postoperative recovery auxiliary material is shown in figure 1, wherein the material is a cylinder with a round head at one end, the material sequentially comprises an inner core 1, a water-absorbing expansion layer 2 and a medicine layer 3 from inside to outside, and the medicine layer 3 is prepared from mupirocin ointment; the round end of the inner core 1 is connected with the water-absorbing expansion layer 2, and the part which is not connected between the inner core 1 and the water-absorbing expansion layer 2 is also provided with a lubricating layer 9.

In this embodiment, the water-absorbing swelling layer 2 can be made of a flexible polymer water-absorbing material. The polymer water-absorbing material with the water-absorbing expansion rate of 100-200% is preferably selected, and the effect is better when the thickness of the water-absorbing expansion layer 2 is designed to be 2-4 mm.

Example 2

An anorectal disease postoperative recovery auxiliary material is different from that of embodiment 1, and as shown in figure 2, the anorectal disease postoperative recovery auxiliary material further comprises a bottom patch 4, wherein the bottom patch 4 is connected with a non-round end of an inner core 1, and a lubricating layer 9, a water-swelling layer 2 and a medicine layer 3 are sequentially arranged on the upper surface of the bottom patch 4; the material is provided with a through hole 5 along the direction of the central axis of the cylinder, and the lower end of the through hole 5 penetrates through the bottom sticker 4.

In this embodiment, the bottom sticker 4 and the inner core 1 may be of an integral structure; the bottom tape 4 and the bottom end of the core 1 may be fixedly connected by an adhesive or the like.

Example 3

The utility model provides an anorectal disease postoperative resumes auxiliary material, is different from embodiment 2, as shown in figure 3, medicine permeable membrane 6 still is provided with in the one side that medicine layer 3 kept away from water-swelling layer 2, medicine permeable membrane 6 is for being provided with the elasticity anti-sticking membrane of a plurality of medicine permeable holes, and bottom subsides 4 lower surface has set gradually not dried glue layer 7 and release paper 8.

Example 4

Different from the embodiment 1, the material for assisting postoperative recovery of anorectal diseases comprises the following components in parts by weight:

mupirocin 1

Liquidambar resin 12

Olibanum 5

Myrrha 5

Chinese medicine extract 15

30 parts of polyethylene glycol;

the traditional Chinese medicine extract is prepared from the following components in parts by weight:

root of red-rooted salvia 10

Forsythia 10

Ligusticum wallichii 8

Herba Hedyotidis Diffusae 8

Pseudobulbus Cremastrae Seu pleiones 5

Lithospermum erythrorhizon 5

Peach kernel 3

Coptis chinensis Franch 3

2, oriental wormwood;

the preparation method of the medicine for preparing the medicine layer 3 comprises the following steps:

s1, crushing components for preparing a traditional Chinese medicine extract into traditional Chinese medicine powder of 60 meshes, mixing the traditional Chinese medicine powder with water according to a weight ratio of 1:10, soaking for 10 hours at 75 ℃, and stirring and leaching for 2 hours at 75 ℃ to obtain a first leaching solution; mixing the Chinese medicinal extraction residue with anhydrous ethanol at a weight ratio of 1:5, soaking at 50 deg.C for 5 hr, and stirring at 50 deg.C for 2 hr to obtain a second extractive solution; mixing the first leaching solution and the second leaching solution uniformly, distilling to remove ethanol, standing for 1h, filtering to obtain clear liquid, and concentrating the clear liquid to relative density of 1.1 at 70 ℃ to obtain traditional Chinese medicine extract;

s2, respectively grinding mupirocin, resina Liquidambaris, frankincense and myrrh into 150-mesh powder, and then uniformly mixing to obtain mixed powder;

s3, adding the mixed powder into the traditional Chinese medicine extract, uniformly mixing, and grinding for 0.5h at the temperature of 30 ℃; adding polyethylene glycol, and grinding at 30 deg.C for 1h to obtain the medicine for preparing the medicine layer 3.

Example 5

Different from the embodiment 2, the material for assisting postoperative recovery of anorectal diseases comprises the following components in parts by weight:

mupirocin 2

Resina Liquidambaris 20

Olibanum 8

Myrrha 8

Chinese medicine extract 30

Polyethylene glycol 40;

saviae Miltiorrhizae radix 30

Forsythia 20

Ligusticum wallichii 15

Herba Hedyotidis Diffusae 12

Pseudobulbus Cremastrae Seu pleiones 8

Lithospermum erythrorhizon 8

Peach kernel 8

Coptis chinensis Franch 5

5, oriental wormwood;

s1, crushing components for preparing a traditional Chinese medicine extract into traditional Chinese medicine powder of 100 meshes, mixing the traditional Chinese medicine powder with water according to a weight ratio of 1:20, soaking for 15 hours at 80 ℃, and stirring and leaching for 5 hours at 80 ℃ to obtain a first leaching solution; mixing the Chinese medicinal extraction residue with anhydrous ethanol at a weight ratio of 1:10, soaking at 60 deg.C for 12 hr, and stirring at 60 deg.C for 5 hr to obtain second extractive solution; mixing the first leaching solution and the second leaching solution uniformly, distilling to remove ethanol, standing for 1h, filtering to obtain clear liquid, and concentrating the clear liquid to relative density of 1.1 at 70 ℃ to obtain traditional Chinese medicine extract;

s2, respectively grinding mupirocin, resina Liquidambaris, frankincense and myrrh into 180-mesh powder, and then uniformly mixing to obtain mixed powder;

s3, adding the mixed powder into the traditional Chinese medicine extract, uniformly mixing, and grinding for 1h at 50 ℃; adding polyethylene glycol, and grinding at 50 deg.C for 2 hr to obtain the medicine for preparing medicine layer 3.

Example 6

Different from the embodiment 3, the material for assisting postoperative recovery of anorectal diseases for preparing the medicine layer 3 comprises the following components in parts by weight:

mupirocin 1.5

Resina Liquidambaris 15

Olibanum 6

Myrrha 6

Chinese medicinal extract 20

Polyethylene glycol 35;

saviae Miltiorrhizae radix 20

Forsythia fruit 15

Ligusticum wallichii 12

Herba Hedyotidis Diffusae 10

Pseudobulbus Cremastrae Seu pleiones 6

Lithospermum erythrorhizon 6

Peach kernel 5

Coptis chinensis Franch 4

Oriental wormwood 3;

s1, crushing components for preparing a traditional Chinese medicine extract into traditional Chinese medicine powder of 80 meshes, mixing the traditional Chinese medicine powder with water according to a weight ratio of 1:15, soaking at 70 ℃ for 12 hours, and stirring and leaching at 70 ℃ for 3 hours to obtain a first leaching solution; mixing the Chinese medicinal extraction residue with anhydrous ethanol at a weight ratio of 1:8, soaking at 50 deg.C for 10 hr, and stirring at 50 deg.C for 3 hr to obtain a second extractive solution; mixing the first leaching solution and the second leaching solution uniformly, distilling to remove ethanol, standing for 1h, filtering to obtain clear liquid, and concentrating the clear liquid to relative density of 1.1 at 70 ℃ to obtain traditional Chinese medicine extract;

s2, respectively grinding mupirocin, resina Liquidambaris, frankincense and myrrh into 200-mesh powder, and then uniformly mixing to obtain mixed powder;

s3, adding the mixed powder into the traditional Chinese medicine extract, uniformly mixing, and grinding for 1h at 40 ℃; adding polyethylene glycol, and grinding at 40 deg.C for 2 hr to obtain the medicine for preparing the medicine layer 3.

Evaluation of bacteriostatic Effect of drugs for preparing drug layer

The bacteriostatic effects of the drugs for preparing the drug layer and the 2% mupirocin ointment in examples 4-6 were evaluated in comparison, and the results are shown in table 1.

TABLE 1 evaluation results of bacteriostatic effects

From the above results, it can be seen that the mupirocin and the traditional Chinese medicine composition are used in combination, and compared with mupirocin used alone, the mupirocin antibacterial composition has better antibacterial performance.

The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents and improvements made within the spirit and principle of the present invention are intended to be included within the scope of the present invention.

Claims

1. The utility model provides an anorectal disease postoperative resumes auxiliary material, a serial communication port, the material is the cylinder that one end is the button head, the material includes inner core, water swelling layer and medicine layer from inside to outside in proper order, the one end of the button head of inner core with the water swelling layer is connected, the inner core with the part of not connecting still is provided with the lubricating layer between the water swelling layer.

2. The material as claimed in claim 1, wherein the material is provided with a through hole along the central axis of the cylinder.

3. The material as claimed in claim 2, further comprising a bottom patch connected to the non-round end of the inner core, wherein a lubricating layer, a water-swelling layer and a drug layer are sequentially disposed on one side of the bottom patch on which the cylinder is disposed, and the through hole penetrates through the bottom patch.

4. The material as in claim 3, wherein a drug permeable membrane is further disposed on a side of the drug layer away from the water-swellable layer, and the drug permeable membrane is an elastic membrane having a plurality of drug permeable holes.

5. The material of claim 4, wherein the drug permeable membrane is an anti-adhesion membrane.

6. A material as claimed in claim 5, in which the side of the base sticker remote from the cylinder is provided with a layer of non-setting adhesive.

7. The material as claimed in claim 1, wherein the water-swelling layer is made of a flexible polymeric water-absorbing material, the polymeric water-absorbing material has a water-swelling rate of 100-200%, and the water-swelling layer has a thickness of 2-4 mm.

8. The material of any of claims 1-7, wherein the drug for preparing the drug layer comprises the following components in parts by weight: