CN112791008A

CN112791008A - Application of coenzyme in anti-aging beauty skin care product, skin care product containing coenzyme and preparation method of skin care product

Info

Publication number: CN112791008A
Application number: CN202110125191.4A
Authority: CN
Inventors: 张继军; 张媛; 周娜娜; 赵国淼; 王小艳; 陈博; 杨凯; 许克家; 安泰; 沈雪梅
Original assignee: Cofco Corp; Cofco Nutrition and Health Research Institute Co Ltd
Current assignee: Cofco Corp; Cofco Nutrition and Health Research Institute Co Ltd
Priority date: 2021-01-29
Filing date: 2021-01-29
Publication date: 2021-05-14
Anticipated expiration: 2041-01-29
Also published as: CN112791008B

Abstract

The invention relates to the field of cosmetic products, in particular to application of coenzyme in an anti-aging beauty skin care product, a skin care product containing the coenzyme and a preparation method of the skin care product, wherein the coenzyme contains NMN, NAD and NADH. The skin care product prepared by the invention can improve the anti-aging capability of skin, particularly face, tighten skin, fade black spots, achieve the anti-aging effect, and has higher safety and thermal stability.

Description

Application of coenzyme in anti-aging beauty skin care product, skin care product containing coenzyme and preparation method of skin care product

Technical Field

The invention relates to the field of cosmetic products, in particular to application of coenzyme in an anti-aging beauty skin care product, a skin care product containing the coenzyme and a preparation method thereof.

Background

Skin aging is characterized by thinning, fragility, delayed wound healing, and reduced levels of skin cells (e.g., keratinocytes and melanocytes), accompanied by reduced adult stem cells, etc. The theory of aging holds that: when the defense and repair mechanisms of the body are defective, damage is accumulated continuously, and aging is caused. Thus, there is a balance between repair and senescence, and maintaining this balance requires the cells to repair DNA damage effectively. When the damage cannot be repaired, it is necessary to remove these damaged cells. Adult stem cells are essential for replenishing cells that are eliminated from tissues, but their capacity gradually decreases with age, depletion of stem cells, and accumulation of senescent cells.

Human beings are affected by various factors in the environment, such as ultraviolet irradiation, and DNA is damaged, which is also a common factor in skin aging. In places where ultraviolet light is intense, many human skin cells undergo genetic damage, and if the damage is difficult to repair without entering the apoptotic pathway, the cells age. In addition, temperature and humidity changes are strong irritations, and the exposed skin inevitably responds to the influences of temperature and humidity, and the irritations are applied to the skin for a long time to age the skin. In addition, cellular metabolism in the human body generates oxygen radicals, and these energetic oxygen radicals are continuously collided in the cells to cause DNA damage, protein denaturation, etc., and long-term damage causes irreversible aging of the cells. The body is not without much energy for damage, and there are in fact corresponding repair mechanisms in the body to deal with cellular damage, such as the typical DNA repair mechanisms. When the cells cannot be repaired, the cells enter an apoptosis stage, degrade and phagocytose the whole cells, and then differentiate by another important cell, namely stem cells, so as to compensate the apoptotic cells. However, this system is not always operational. With age, the overall repair capacity of the body becomes increasingly difficult to cope with cell damage, and the greater problem is that stem cells in the body are not available indefinitely. Thus, as age progresses, stem cells become senescent and depleted, with the end result that repair cannot compensate for the damage, and the cells age, including of course, the aging of the skin.

In order to prevent skin aging, various skin care products are applied to the face to keep the facial skin smooth and youthful, but the existing skin care products have to be improved and developed in terms of the effect of preventing facial skin aging.

Disclosure of Invention

The invention aims to improve the effect of the existing skin care product on preventing facial skin aging, and provides application of coenzyme in an anti-aging beauty skin care product, the skin care product containing the coenzyme and a preparation method thereof.

In order to achieve the above objects, the present invention provides, in one aspect, an application of a coenzyme in the preparation of an anti-aging cosmetic skin care product; wherein the coenzyme comprises NMN, NAD and NADH.

In a second aspect, the invention provides a skin care product comprising a coenzyme comprising NMN, NAD and NADH.

Preferably, the skin care product also contains auxiliary materials; wherein the auxiliary materials comprise a humectant, an emulsifier and a preservative.

In a third aspect of the invention, a method for preparing a skin care product is provided, the method comprises stirring a coenzyme and an auxiliary material, wherein the coenzyme contains NMN, NAD and NADH, and the auxiliary material contains a humectant, an emulsifier and a preservative.

The invention can obtain the following beneficial effects:

1. according to the invention, three components of NMN, NAD and NADH are applied to the anti-aging beauty skin care product, the three coenzymes can synergistically play an anti-aging effect, and the skin care product can further improve the anti-aging capability of skin, particularly face, so that the skin is compact, black spots are lightened, and the anti-aging effect is achieved.

2. The coenzyme in the skin care product containing the coenzyme is a human endogenous substance, so that the skin care product is high in safety and good in thermal stability.

Detailed Description

The endpoints of the ranges and any values disclosed herein are not limited to the precise range or value, and such ranges or values should be understood to encompass values close to those ranges or values. For ranges of values, between the endpoints of each of the ranges and the individual points, and between the individual points may be combined with each other to give one or more new ranges of values, and these ranges of values should be considered as specifically disclosed herein.

In a first aspect, the invention provides an application of coenzyme in preparing an anti-aging beauty skin care product; wherein the coenzyme comprises NMN, NAD and NADH.

The three components of NMN, NAD and NADH are applied to the anti-aging beauty skin care product, and the three components are found to play a synergistic effect, so that a better anti-aging beauty effect is played under the condition that a single component or two components are used in the same amount.

In the research by the inventors of the present invention, it was found that when the NAD is used in an amount of 4 to 1000 parts by weight (for example, 4, 6, 20, 50, 100, 150, 200, 400, 600, 800, 1000 parts by weight) and the NADH is used in an amount of 4 to 1500 parts by weight (for example, 4, 6, 20, 50, 100, 150, 200, 400, 500, 600, 800, 1000, 1200, 1400, 1500 parts by weight) relative to 100 parts by weight of NMN, the three coenzymes can further synergistically exert the anti-aging effect, and the skin care product can further improve the anti-aging capability of the skin, particularly the face, make the skin firmer, further lighten dark spots, and achieve a better anti-aging effect.

According to a particularly preferred embodiment of the present invention, the skin care product is more effective in anti-aging when the NAD is used in an amount of 40 to 500 parts by weight and the NADH is used in an amount of 40 to 500 parts by weight, relative to 100 parts by weight of NMN. More preferably, the skin care product has better anti-aging effect when the NAD is used in an amount of 50 to 150 parts by weight and the NADH is used in an amount of 60 to 200 parts by weight, relative to 100 parts by weight of NMN.

Preferably, the coenzyme further comprises NADP and/or NADPH in order to improve the anti-aging ability of the skin care product.

Preferably, the skin care product has a better anti-aging effect when the NADP is used in an amount of 50 to 100 parts by weight (for example, it may be 50, 60, 70, 80, 90, 100 parts by weight) relative to 100 parts by weight of NMN.

Preferably, the skin care product has a better anti-aging effect when the NADPH is used in an amount of 30 to 70 parts by weight (for example, it may be 30, 40, 50, 60, 70 parts by weight) with respect to 100 parts by weight of NMN.

In a second aspect, the invention also provides a skin care product comprising a coenzyme comprising NMN, NAD and NADH.

In the research by the inventors of the present invention, it was found that when the NAD content is 4 to 1000 parts by weight (for example, may be 4, 6, 20, 50, 100, 150, 200, 400, 600, 800, 1000 parts by weight) and the NADH content is 4 to 1500 parts by weight (for example, may be 4, 6, 20, 50, 100, 150, 200, 400, 500, 600, 800, 1000, 1200, 1400, 1500 parts by weight) with respect to 100 parts by weight of NMN, the three coenzymes can further synergistically exert the anti-aging effect, and the skin care product can further improve the anti-aging capability of the skin, particularly the face, make the skin compact, lighten dark spots, and achieve the anti-aging effect.

According to a particularly preferred embodiment of the present invention, the skin care product has an excellent anti-aging effect when the NAD content is 40 to 500 parts by weight and the NADH content is 40 to 500 parts by weight with respect to 100 parts by weight of NMN. Further, the skin care product has an anti-aging effect when the NAD is contained in an amount of 50 to 150 parts by weight and the NADH is contained in an amount of 60 to 200 parts by weight, relative to 100 parts by weight of NMN.

According to the present invention, the coenzyme may further contain NADP and/or NADPH in order to further improve the anti-aging ability of the skin care product.

Preferably, the skin care product has a better anti-aging effect when the NADP is contained in an amount of 50 to 100 parts by weight (for example, may be 50, 60, 70, 80, 90, 100 parts by weight) with respect to 100 parts by weight of NMN.

Preferably, the skin care product has a better anti-aging effect when the NADPH is contained in an amount of 30 to 70 parts by weight (for example, may be 30, 40, 50, 60, 70 parts by weight) with respect to 100 parts by weight of NMN.

According to the invention, the skin care product can also contain auxiliary materials in order to be better compatible with the active components. Preferably, the auxiliary materials contain a humectant, an emulsifier and a preservative.

According to the present invention, the humectant is not particularly limited, and may be any of various humectants commonly used in the art. Preferably, the moisturizer is selected from the group consisting of hyaluronic acid, sodium hyaluronate, glycerin, butylene glycol, and aloe vera extract. Particularly preferably, the moisturizer is hyaluronic acid, aloe vera extract, butylene glycol and glycerin.

According to the present invention, the emulsifier is not particularly limited, and various emulsifiers commonly used in the art may be used. Preferably, the emulsifier is selected from the group consisting of monoglycerides, tweens, methylglucamine hemistearate, polyglycerol esters and steareth. Particularly preferably, the emulsifier is a polyglycerol ester.

According to the present invention, the preservative is not particularly limited, and various preservatives commonly used in the art may be used. Preferably, the preservative is selected from sorbic acid, potassium sorbate, phenoxyethanol, and dehydroacetic acid. Particularly preferably, the preservative is sorbic acid.

In order to better realize the compatibility between the auxiliary materials and the active components and exert the anti-aging effect of the active components, according to the invention, the content of the emulsifier can be 50-150 parts by weight, the content of the humectant can be 2000-3500 parts by weight and the content of the preservative can be 10-80 parts by weight relative to 100 parts by weight of NMN. Further, when the content of the emulsifier is 60 to 100 parts by weight (for example, may be 60, 70, 80, 90, 100 parts by weight), the content of the humectant is 2400 parts by weight 3300 parts by weight (for example, may be 2400, 2500, 2600, 2700, 2800, 2900, 3000, 3100, 3200, 3300 parts by weight), and the content of the preservative is 20 to 60 parts by weight (for example, may be 20, 30, 40, 50, 60 parts by weight), with respect to 100 parts by weight of NMN, the anti-aging effect of the skin care product is more excellent.

The specific type of the skin care product is not particularly limited in the invention, and the skin care product can be various skin care products commonly used in the field, and preferably, the skin care product is at least one of a cream-like skin care product, an emulsion-like skin care product and a facial mask-like skin care product.

In a third aspect, the invention also provides a method for preparing a skin care product, which comprises stirring the coenzyme and the auxiliary materials.

In order to further improve the uniformity degree of material mixing, the mixing and stirring time is 50-160min, and the mixing and stirring speed is 300-.

The inventor of the invention finds in research that when the stirring is graded stirring, the uniformity degree of materials is higher, and the anti-aging effect of the skin care product is better. The step-by-step stirring method may include low-speed stirring, medium-speed stirring, and high-speed stirring. The low-speed stirring speed is 300-600r/min, and the time is 10-30 min; the speed of the medium-speed stirring is 600-1000r/min, and the time is 20-60 min; the high-speed stirring speed is 1200-2000r/min, and the time is 20-70 min.

According to a particularly preferred embodiment of the invention, the moisturizing agents are hyaluronic acid, aloe vera extract, butylene glycol and glycerol, the emulsifying agent is a polyglycerol ester, the preservative is sorbic acid and the coenzymes are NMN, NAD, NADH, NADP and NADPH. The preparation method comprises the following steps of adding water, glycerol and butanediol into a stirrer according to the above dosage, then adding hyaluronic acid, aloe extract, sorbic acid, polyglycerol ester, NMN, NAD, NADH, NADPH and NADPH into the stirrer sequentially according to the above dosage, stirring, and finally preparing into a paste. Wherein, the stirring process adopts the mode of stirring in grades: firstly carrying out low-speed stirring, then carrying out medium-speed stirring and finally carrying out high-speed stirring, wherein the low-speed stirring speed is 300-600r/min, the time is 10-30min, the medium-speed stirring speed is 600-1000r/min, the time is 20-60min, the high-speed stirring speed is 1200-2000r/min, and the time is 20-70min, so that the anti-aging effect of the skin care product is better.

The present invention will be described in detail below by way of examples.

Examples 1 to 5

For illustrating the skin care product provided by the invention and the preparation method thereof

Adding water, glycerol and butanediol into a stirrer in sequence according to the dosage in the table 1, then adding hyaluronic acid, aloe extract, sorbic acid, polyglycerol ester, NMN, NAD and NADH into the stirrer in sequence according to the dosage in the table 1, stirring, and finally preparing into paste. Wherein, the stirring process adopts a grading stirring mode as shown in table 1: firstly stirring at a low speed, then stirring at a medium speed, and finally stirring at a high speed to prepare the skin care product.

TABLE 1

Example 6

A paste was prepared in the same manner as in example 1, except that the coenzyme further included NADP and NADPH in amounts of 60 parts by weight and 50 parts by weight, respectively.

Example 7

A cream-type skin care preparation was prepared in the same manner as in example 1, except that the stepwise stirring was not employed.

Example 8

A cream-type skin care preparation was prepared in the same manner as in example 1, except that hyaluronic acid was replaced with an equal amount of sodium hyaluronate, sorbic acid was replaced with an equal amount of phenoxyethanol, and polyglycerin ester of example 1 was replaced with an equal amount of monoglyceride.

Comparative example 1

Skin care product for reference and preparation method thereof

A cream skin care preparation was prepared in the same manner as in example 1, except that the coenzyme added did not include NMN and the amount of NMN not added was replenished by increasing the amounts of NAD and NADH in proportion to the amounts of NAD and NADH in example 1.

Comparative example 2

Skin care product for reference and preparation method thereof

A cream-type skin care preparation was prepared in the same manner as in example 1, except that the coenzyme added did not include NAD, and the amount of NAD not added was replenished by increasing the amounts of NAD and NADH in proportion to the amounts of NAD and NADH in example 1.

Comparative example 3

Skin care product for reference and preparation method thereof

A cream-type skin care preparation was prepared in the same manner as in example 1, except that the coenzyme added did not include NADH, and the amount of NADH not added was replenished by increasing the amounts of NAD and NADH in proportion to the amounts of NAD and NADH in example 1.

Test example 1

The skin care products obtained in examples 1 to 8 and comparative examples 1 to 3 were tested. 110 women aged 30-60 years were randomly divided into 11 groups of 10 people each. The first group is evenly smeared on the face by using the skin care product of the embodiment 1 every day to carry out face care; the second group was facial care daily using the skin care product of example 2; the third group used the skin care product of example 3 daily for facial care; a fourth group used the skin care product of example 4 daily for facial care; a fifth group was facial care daily using the skin care product of example 5; the sixth group was applied to the face with the skin care product of example 6 every day for facial care; the seventh group was applied to the face uniformly daily using the skin care product of example 7 for facial care; the eighth group was applied to the face uniformly every day using the skin care product of example 8 for facial care; a ninth group was facial care daily using the skin care product of comparative example 1; the tenth group was facial care daily using the skin care product of comparative example 2; the eleventh group was facial care daily using the skin care product of comparative example 3. The medicine is administered in the morning and evening, and 1 treatment course is administered every week for 8 treatment courses. After 8 treatment sessions, 5 experts scored the overall anti-aging effect of each group (including skin elasticity, tenderness, moistness, wrinkles, skin smoothness, appearance texture) and then averaged. The results are shown in Table 2.

TABLE 2

The results in table 2 show that the technical scheme of the invention can improve the anti-aging capability of skin, particularly face, tighten skin, fade black spots, achieve the anti-aging effect, and have higher safety and thermal stability.

Test example 2

The skin care products obtained in examples 1 to 8 and comparative examples 1 to 3 were subjected to a thermal stability test. The skin care products of examples 1 to 8 and comparative examples 1 to 3, which were completely packaged, were placed in the incubator at a constant temperature of 40 ℃ in advance. And taking out after 24 hours, and visually observing whether oil-water separation occurs or not after the temperature is returned to room temperature. The thermal stability test results are shown in table 3.

TABLE 3

Example numbering	Thermal stability
		Example 1	Without oil-water separation phenomenon
Example 2	Without oil-water separation phenomenon
		Example 3	Without oil-water separation phenomenon
Example 4	Without oil-water separation phenomenon
		Example 5	Without oil-water separation phenomenon
Example 6	Without oil-water separation phenomenon
		Example 7	Without oil-water separation phenomenon
Example 8	Without oil-water separation phenomenon
		Comparative example 1	Slight oil-water separation phenomenon
Comparative example 2	Slight oil-water separation phenomenon
		Comparative example 3	Slight oil-water separation phenomenon

The results in table 3 show that the skin care product provided by the technical scheme of the invention has higher thermal stability.

The preferred embodiments of the present invention have been described above in detail, but the present invention is not limited thereto. Within the scope of the technical idea of the invention, many simple modifications can be made to the technical solution of the invention, including combinations of various technical features in any other suitable way, and these simple modifications and combinations should also be regarded as the disclosure of the invention, and all fall within the scope of the invention.

Claims

1. The application of coenzyme in the preparation of anti-aging beauty skin care products;

wherein the coenzyme comprises NMN, NAD and NADH.

2. The use according to claim 1, wherein the NAD is used in an amount of 4-1000 parts by weight and the NADH is used in an amount of 4-1500 parts by weight, relative to 100 parts by weight of NMN;

preferably, the NAD is used in an amount of 40 to 500 parts by weight and the NADH is used in an amount of 40 to 500 parts by weight, relative to 100 parts by weight of NMN;

more preferably, the NAD is used in an amount of 50 to 150 parts by weight and the NADH is used in an amount of 60 to 200 parts by weight, relative to 100 parts by weight of NMN;

preferably, the coenzyme further comprises NADP and/or NADPH.

3. A skin care product characterized in that it contains a coenzyme;

the coenzyme contains NMN, NAD and NADH.

4. The skin care preparation according to claim 3, wherein the NAD is contained in an amount of 4 to 1000 parts by weight and the NADH is contained in an amount of 4 to 1500 parts by weight, relative to 100 parts by weight of NMN;

preferably, the NAD content is 40-500 parts by weight and the NADH content is 40-500 parts by weight relative to 100 parts by weight of NMN;

more preferably, the NAD content is 50 to 150 parts by weight and the NADH content is 60 to 200 parts by weight, relative to 100 parts by weight of NMN;

preferably, the coenzyme further comprises NADP and/or NADPH.

5. The skin care product according to claim 3 or 4, wherein the skin care product further comprises an adjuvant;

wherein the auxiliary materials comprise a humectant, an emulsifier and a preservative.

6. A skin care product according to claim 5 wherein the humectant is selected from hyaluronic acid, sodium hyaluronate, glycerol, butylene glycol and aloe extract, preferably hyaluronic acid, aloe extract, butylene glycol and glycerol;

and/or, the emulsifier is selected from the group consisting of monoglycerides, tweens, methylglucamine hemistearate, polyglycerol esters and steareth, preferably polyglycerol esters;

and/or the preservative is selected from sorbic acid, potassium sorbate, phenoxyethanol and dehydroacetic acid, preferably sorbic acid.

7. The skin care preparation according to claim 5 or 6, wherein the emulsifier is contained in an amount of 50 to 150 parts by weight, the humectant is contained in an amount of 2000 to 3500 parts by weight, and the preservative is contained in an amount of 10 to 80 parts by weight, relative to 100 parts by weight of NMN.

8. The skin care product of any one of claims 3-7, wherein the skin care product comprises at least one of a cream skin care product, an emulsion skin care product, and a facial mask skin care product.

9. A method of preparing a skin care product according to any one of claims 5 to 7, comprising: stirring the coenzyme according to any one of claims 5 to 7 and auxiliary materials to obtain the skin care product;

preferably, the stirring time is 50-160 min;

and/or the stirring speed is 300-2000 r/min.

10. The method of claim 9, wherein the method of stirring is fractional stirring;

the method for stirring in a grading way comprises the steps of firstly stirring at a low speed, then stirring at a medium speed and finally stirring at a high speed;

wherein the low-speed stirring speed is 300-600r/min, and the time is 10-30 min;

wherein the medium-speed stirring speed is 600-1000r/min, and the time is 20-60 min;

wherein the high-speed stirring speed is 1200-2000r/min, and the time is 20-70 min.