CN112790114B - Experimental device system for giving stress stimulation to rodents - Google Patents
Experimental device system for giving stress stimulation to rodents Download PDFInfo
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- CN112790114B CN112790114B CN202011329735.0A CN202011329735A CN112790114B CN 112790114 B CN112790114 B CN 112790114B CN 202011329735 A CN202011329735 A CN 202011329735A CN 112790114 B CN112790114 B CN 112790114B
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- 230000004938 stress stimulation Effects 0.000 title claims abstract description 16
- 241000283984 Rodentia Species 0.000 title claims abstract description 14
- 238000012544 monitoring process Methods 0.000 claims description 7
- 239000000523 sample Substances 0.000 claims description 7
- 238000004891 communication Methods 0.000 claims description 6
- 238000009533 lab test Methods 0.000 claims 1
- 238000002474 experimental method Methods 0.000 description 12
- 241000699670 Mus sp. Species 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 230000000638 stimulation Effects 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 241000700159 Rattus Species 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000013401 experimental design Methods 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000007267 depressive like behavior Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 210000001503 joint Anatomy 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K1/00—Housing animals; Equipment therefor
- A01K1/02—Pigsties; Dog-kennels; Rabbit-hutches or the like
- A01K1/03—Housing for domestic or laboratory animals
- A01K1/031—Cages for laboratory animals; Cages for measuring metabolism of animals
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K1/00—Housing animals; Equipment therefor
- A01K1/02—Pigsties; Dog-kennels; Rabbit-hutches or the like
- A01K1/035—Devices for use in keeping domestic animals, e.g. fittings in housings or dog beds
- A01K1/0356—Feeding or drinking devices associated with cages
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K29/00—Other apparatus for animal husbandry
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- Life Sciences & Earth Sciences (AREA)
- Environmental Sciences (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- General Health & Medical Sciences (AREA)
- Birds (AREA)
- Instructional Devices (AREA)
Abstract
The invention discloses an experimental device system for giving stress stimulation to rodents, which comprises a mechanical main body, a control host machine and a mobile machine, wherein the control host machine is used for controlling the operation of the mechanical main body; the machine main body comprises a bottom plate, an upper frame, a storage cage, a lifting assembly and a swinging assembly; the storage cage and the swinging assembly are arranged on the bottom plate; the upper frame is arranged in parallel with the plate surface of the bottom plate; the lifting assembly comprises a guide rod, a driving motor and at least one food cage which are vertically arranged, and two ends of the guide rod are respectively and fixedly connected to the bottom plate and the upper frame; the driving motor drives the food cage to move up and down along the guide rod; the swing assembly comprises an operation cage with an opening at the upper end and four driving cylinders; the control host comprises a microcomputer and a plc editing module, and the microcomputer is used for controlling the driving motor and the driving cylinder to operate and stop. The invention is electrically controlled, saves manpower and has simple operation.
Description
Technical Field
The invention relates to the field of experimental systems, in particular to an experimental device system for giving stress stimulation to rodents.
Background
In modern society, with the pace of life increasing, people experience complex and diverse stresses. Research has shown that 75% -90% of the disease development is associated with stress. The research on the back mechanism of stress pathogenesis has profound significance to human health.
The current laboratory models of stress are mainly: (1) plantar electrical stimulation; (2) restraint stress; (3) Chronic unpredictable stress (tilting cage, removing bedding, fasting and water deprivation, etc.)
The animal model of 'plantar electrical stimulation' simulates the body stress suffered by a human, and is realized by placing a mouse in an electrified metal cage and controlling the current intensity, frequency and time through a current controller.
"Chronic unpredictable stress" is an animal model that uses different stress stimuli, such as tilting cages, removing bedding, fasting to deprive water, etc., to simulate human depression-like behavior resulting from various stress stresses.
At present, the stress models need to be completed by experimenters with more energy. The electrical stimulation of the sole requires that an experimenter takes mice out of a cage one by one, places the mice into an electric shock box, and then places the mice back into the cage after the electric shock is finished; the tilting cage body, the removal of padding and the fasting and water-deprivation need experimenters to operate one by one, and more efforts are needed to complete the operation, especially when the experimental design is operated in non-working time, the operation is time-consuming and labor-consuming.
Disclosure of Invention
The invention provides an experimental device system for applying stress stimulation to rodents, and solves the problem that the stress models are required to be completed by experimenters with more energy. The electrical stimulation of the sole requires that an experimenter takes out the mice from the cage one by one, places the mice into an electric shock box, and then places the mice back into the cage after the electric shock is finished; the cage body of slope, get rid of the bedding and padding, the water of fasting is forbidden all needs the experimenter to operate one by one, needs to invest more energy to accomplish, especially when the experimental design is operated at non-operating time, the problem of consuming time and wasting force.
The technical scheme of the invention is realized as follows:
an experimental device system for giving stress stimulation to rats comprises a mechanical main body, a control host machine and a mobile machine, wherein the control host machine is used for controlling the operation of the mechanical main body;
the machine main body comprises a bottom plate, an upper frame, a storage cage, a lifting assembly and a swinging assembly; the lifting assembly and the swinging assembly are respectively positioned at two opposite sides of the storage cage; the storage cage and the swinging assembly are arranged on the bottom plate; the upper frame is arranged in parallel with the plate surface of the bottom plate; the lifting assembly comprises a guide rod, a driving motor and at least one food cage which are vertically arranged, and two ends of the guide rod are respectively and fixedly connected to the bottom plate and the upper frame; the driving motor drives the food cage to move up and down along the guide rod; the swing assembly comprises an operation cage with an opening at the upper end and four driving cylinders, the operation cage is connected to the bottom plate through a movable piece, and the bottom surface of the operation cage is rectangular; the four driving cylinders are fixed on the bottom plate, output end screw rods of the four driving cylinders are connected to the bottom surface of the operation cage, and the connection positions are close to four corners of the bottom surface of the operation cage;
the control host comprises a microcomputer and a plc editing module, and the microcomputer is used for controlling the driving motor and the driving cylinder to operate and stop.
Preferably, a first outlet is formed in one side, close to the driving assembly, of the storage cage, and a second outlet is formed in one side, close to the swinging assembly, of the storage cage.
Preferably, when the operation cage is in a horizontal placement state, the horizontal position of the upper end face of the operation cage and the horizontal position of the bottom face of the storage cage are on the same horizontal plane.
Preferably, a drawing door plate is further arranged at the first outlet, the drawing door plate is vertically inserted from the upper end of the storage cage, and the drawing door plate can move up and down.
Preferably, a movable door plate is arranged on the second outlet and connected to the bottom surface of the storage cage through a rotating shaft; and when the movable door plate is opened, one end of the movable door plate, which is far away from the rotating shaft, is overlapped at the edge of the upper port of the operation cage.
Preferably, the movable part comprises a connecting part connected to the bottom surface of the operating cage and a supporting rod connected to the connecting part, and one end of the supporting rod, far away from the connecting part, is fixed on the bottom plate; the connecting piece is spherical.
Preferably, the bottom of the operation cage is provided with a movable groove matched with the connecting piece, the movable groove is in a segment shape, the end opening of the movable groove is circular, and the diameter of the circle is smaller than the spherical diameter of the movable groove.
Preferably, the upper rack is further provided with a monitoring probe, and the monitoring probe is electrically connected with the control host and used for monitoring the state of the experimental object in the storage cage.
Preferably, the mobile phone adopts a mobile phone, an app system is loaded on the mobile phone, and the app system is used for inputting instructions and then transmitting the instructions to the control host.
Preferably, the bottom of the storage cage is also provided with a padding component.
The beneficial effect of the invention is that,
according to the invention, the mechanical main body and the control host are arranged, and intelligent control is realized through the control host, so that manual operation is avoided;
the machine main body comprises a bottom plate, an upper frame, a storage cage, a lifting assembly and a swinging assembly; the lifting assembly and the swinging assembly are respectively positioned at two opposite sides of the storage cage; the storage cage and the swinging assembly are arranged on the bottom plate; the upper frame is arranged in parallel with the plate surface of the bottom plate; the lifting assembly comprises a guide rod, a driving motor and at least one food cage which are vertically arranged, and two ends of the guide rod are respectively and fixedly connected to the bottom plate and the upper frame; the driving motor drives the food cage to move up and down along the guide rod; the swing assembly comprises an operation cage with an opening at the upper end and four driving cylinders, the operation cage is connected to the bottom plate through a movable piece, and the bottom surface of the operation cage is rectangular; four it fixes to drive actuating cylinder on the bottom plate, four the output lead screw that drives actuating cylinder is connected the bottom surface of operation cage, and the junction closes on four corners of the bottom surface of operation cage, the food cage and the storing cage matching that set up in the mechanical main part use to and the operation cage that sets up, be used for realizing different stress experiments.
The control host comprises a microcomputer and a plc editing module, the microcomputer is used for controlling the driving motor and the driving cylinder to run and stop, and the microcomputer and the plc editing module are matched for use, so that different control modes are realized, manpower is reduced, and personnel operation is facilitated.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the embodiments or the prior art descriptions will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and other drawings can be obtained by those skilled in the art without creative efforts.
FIG. 1 is a schematic diagram of the structure of an experimental apparatus system for applying stress stimulation to rats according to the present invention;
FIG. 2 is a schematic block diagram of the communication connection between the control host and the mobile unit according to the present invention;
FIG. 3 is a schematic view of the lifting assembly of the present invention;
FIG. 4 is a schematic view of a storage cage according to the present invention;
FIG. 5 is a schematic view of the connecting structure of the connecting member and the storage cage according to the present invention;
fig. 6 is a plan view of the distribution of four driving cylinders in the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Referring to fig. 1 to 6, an experimental apparatus system for applying stress stimulation to rodents includes a mechanical body, a control host 8 for controlling the operation of the mechanical body, and a mobile machine in communication connection with the control host;
the machine body comprises a bottom plate 1, an upper frame 2, a storage cage 3, a lifting assembly and a swinging assembly; the lifting assembly and the swinging assembly are respectively positioned at two opposite sides of the storage cage 3; the bottom plate 1 is provided with a storage cage 3 and a swinging assembly; the upper frame 2 is arranged in parallel with the plate surface of the bottom plate 1; the lifting assembly comprises a guide rod 4, a driving motor 5 and at least one food cage 6 which are vertically arranged, and two ends of the guide rod 4 are respectively and fixedly connected to the bottom plate 1 and the upper frame 2; the driving motor 5 drives the food cage 6 to move up and down along the guide rod 4; the swing assembly comprises an operation cage 7 with an opening at the upper end and four driving cylinders 8, the operation cage 7 is connected to the bottom plate 1 through a movable piece, and the bottom surface of the operation cage 7 is rectangular; the four driving cylinders 8 are fixed on the bottom plate 1, output end screw rods of the four driving cylinders 8 are connected to the bottom surface of the operation cage 7, and the connection positions are close to four corners of the bottom surface of the operation cage 7; wherein food cage 6 realizes going up and down through driving motor 5 to accomplish the butt joint with storing cage 3, food cage 6 can use a plurality ofly, wherein separate water and food, through going up and down, accomplish the stress experiment to the forbidden water of animal in storing cage 3 and fasted.
The control host 9 comprises a microcomputer and a plc editing module, and the microcomputer is used for controlling the driving motor 5 and the driving cylinder 8 to run and stop; wherein the operating condition of actuating cylinder 8 and driving motor 5 is different, and the microcomputer realizes the different operational mode of actuating cylinder 8 and driving motor 5 to guarantee that the experiment can accomplish, wherein the plc editor module is used for entering different operation program, is used for realizing different modes of controlling.
Storing cage 3 closes on drive assembly one side and has seted up first export, closes on swing subassembly one side simultaneously and sets up and has put the second export, first exit position still is provided with pull door plant 16, pull door plant 16 by the vertical insertion in storing cage 3 upper end, just pull door plant 16 can move about from top to bottom, and when up-and-down motion food cage 6 displacement to the relative horizontally position of storing cage 3, pull door plant 16 is opened and is put into food cage 6 with the experimental body in the storing cage 3 and carry out the feed. A movable door plate 10 is arranged on the second outlet, and the movable door plate 10 is connected to the bottom surface of the storage cage 3 through a rotating shaft; and when the movable door plate 10 is opened, one end of the movable door plate 10 far away from the rotating shaft is overlapped at the edge of the upper port of the operation cage 7. When the movable door plate 10 is opened, the movable door plate 10 is erected on the operation cage 7, the four driving cylinders 8 are controlled to be in different running states through the control host 9, the control of the inclination of the operation cage 7 at different angles is achieved, and the stress experiment of the inclined cage body experiment is completed.
When the operation cage 7 is in a horizontal placement state, the horizontal position of the upper end surface of the operation cage 7 and the horizontal position of the bottom surface of the storage cage 3 are on the same horizontal plane.
The movable part comprises a connecting piece 11 connected to the bottom surface of the operation cage 7 and a supporting rod 12 connected to the connecting piece 11, one end, far away from the connecting piece 11, of the supporting rod 12 is fixed on the bottom plate 1, the connecting piece 11 is spherical, a movable groove matched with the connecting piece 11 is formed in the bottom of the operation cage 7, the movable groove 15 is in a segment shape, the port of the movable groove 15 is circular, and the diameter of the circle is smaller than the spherical diameter of the movable groove 15; the arrangement of the connecting piece 11 ensures that the operation cage 7 can be inclined at different angles, so that stress experiments can be completed.
Still be provided with wireless communication module on the control host computer 9, the control host computer 9 passes through wireless communication module and mobile phone communication connection for receive the remote control command that the mobile phone sent, the mobile phone adopts the cell-phone, loads the app system on the cell-phone, and the app system is used for the input instruction, then transmits the instruction to the control host computer, realizes remote control through cell-phone app system.
Still be provided with monitor probe 13 on the upper bracket 2, monitor probe 13 and control host computer 9 electric connection for the state of experiment thing in the control storing cage, and also can realize monitoring on the cell-phone app and look over the image information that monitor probe detected.
The app system is further provided with a user login system, the user login system is provided with login permission distributed by the control host, the experiment system can only participate in limited personnel by distributing the login permission by the control host, the participation of the experiment personnel can be effectively limited, and the research data is prevented from leaking.
In order to ensure that more stress experiments can be completed, an electrostimulation assembly can be further mounted at the bottom of the storage cage 3 and used for electrifying the animal in the storage cage, so that the stress experiments of the electrostimulation of the sole of the animal are completed, and the electrostimulation assembly is not required to be mounted on the storage cage 3 all the time in order to ensure the safety of an experimental body at ordinary times.
The bottom of the storage cage 3 can also be provided with a padding component 14, and the experiment of removing the padding can be completed by withdrawing the padding component 14.
The present invention is not limited to the above preferred embodiments, and any modifications, equivalent substitutions, improvements, etc. within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (8)
1. An experimental device system for giving stress stimulation to rodents is characterized by comprising a mechanical main body, a control host machine for controlling the operation of the mechanical main body and a mobile machine in communication connection with the control host machine;
the machine main body comprises a bottom plate, an upper frame, a storage cage, a lifting assembly and a swinging assembly; the lifting assembly and the swinging assembly are respectively positioned at two opposite sides of the storage cage; the storage cage and the swinging assembly are arranged on the bottom plate; the upper frame is arranged in parallel with the plate surface of the bottom plate; the lifting assembly comprises a guide rod, a driving motor and at least one food cage which are vertically arranged, and two ends of the guide rod are respectively and fixedly connected to the bottom plate and the upper frame; the driving motor drives the food cage to move up and down along the guide rod; the swing assembly comprises an operation cage with an opening at the upper end and four driving cylinders, the operation cage is connected to the bottom plate through a movable piece, and the bottom surface of the operation cage is rectangular; the four driving cylinders are fixed on the bottom plate, output end screw rods of the four driving cylinders are connected to the bottom surface of the operation cage, and the connection positions are close to four corners of the bottom surface of the operation cage;
the control host comprises a microcomputer and a plc editing module, and the microcomputer is used for controlling the driving motor and the driving cylinder to operate and stop;
a first outlet is formed in one side, close to the lifting assembly, of the storage cage, a second outlet is formed in one side, close to the swinging assembly, of the storage cage, a movable door plate is arranged on the second outlet, and the movable door plate is connected to the bottom surface of the storage cage through a rotating shaft; and when the movable door plate is opened, one end of the movable door plate, which is far away from the rotating shaft, is overlapped at the edge of the upper port of the operation cage.
2. The experimental device system for applying stress stimulation to rodents according to claim 1, wherein when said operating cage is in a horizontal position, the horizontal position of the upper end surface of said operating cage is in the same horizontal plane as the horizontal position of the bottom surface of said storage cage.
3. The experimental device system for applying stress stimulation to rodents according to claim 1, wherein a pull door panel is further provided at the first exit position, the pull door panel is vertically inserted from the upper end of the storage cage, and the pull door panel is movable up and down.
4. The experimental device system for applying stress stimulation to rodents according to claim 1, wherein said movable member comprises a connecting member connected to the bottom surface of said cage, and a support rod connected to said connecting member, said support rod being fixed to said bottom plate at an end thereof remote from said connecting member; the connecting piece is in a ball shape.
5. The experimental device system for applying stress stimulation to the rodents as claimed in claim 4, wherein a movable groove matched with the connecting piece is formed in the bottom of the operation cage, the movable groove is in a segment shape, the end opening of the movable groove is in a circular shape, and the diameter of the circular shape is smaller than the spherical diameter of the movable groove.
6. The experimental device system for giving stress stimulation to rodents according to claim 1, wherein a monitoring probe is further arranged on the upper rack, and the monitoring probe is electrically connected with the control host and used for monitoring the state of the laboratory test objects in the storage cage.
7. The experimental device system for applying stress stimulation to rodents according to claim 1, wherein the mobile device is a mobile phone having an app system installed thereon, the app system is used for inputting commands and then transmitting the commands to the control host.
8. The experimental device system for applying stress stimulation to rodents according to claim 1, wherein said bottom of said cage is further provided with a padding assembly.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202011329735.0A CN112790114B (en) | 2021-04-04 | 2021-04-04 | Experimental device system for giving stress stimulation to rodents |
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| CN202011329735.0A CN112790114B (en) | 2021-04-04 | 2021-04-04 | Experimental device system for giving stress stimulation to rodents |
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| CN112790114A CN112790114A (en) | 2021-05-14 |
| CN112790114B true CN112790114B (en) | 2022-11-01 |
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| CN116235729B (en) * | 2023-02-21 | 2024-09-06 | 四川大学华西医院 | Application method of life experiment cabin for simulating deep composite environment |
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