CN112741876A - Traditional Chinese medicine composition for improving sleep - Google Patents
Traditional Chinese medicine composition for improving sleep Download PDFInfo
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- 239000003814 drug Substances 0.000 title claims abstract description 31
- 239000000203 mixture Substances 0.000 title claims description 18
- 241000921449 Rhodobryum roseum Species 0.000 claims abstract description 41
- 235000002956 Gynostemma pentaphyllum Nutrition 0.000 claims abstract description 29
- 244000042430 Rhodiola rosea Species 0.000 claims abstract description 18
- 235000003713 Rhodiola rosea Nutrition 0.000 claims abstract description 18
- 241001080798 Polygala tenuifolia Species 0.000 claims abstract description 15
- 241000037831 Polygonatum sibiricum Species 0.000 claims abstract description 9
- 240000006509 Gynostemma pentaphyllum Species 0.000 claims abstract description 8
- 235000011438 Albizia odoratissima Nutrition 0.000 claims abstract description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 98
- 239000000243 solution Substances 0.000 claims description 86
- 238000007873 sieving Methods 0.000 claims description 48
- 238000010298 pulverizing process Methods 0.000 claims description 42
- 239000008367 deionised water Substances 0.000 claims description 32
- 229910021641 deionized water Inorganic materials 0.000 claims description 32
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 32
- 241000628997 Flos Species 0.000 claims description 23
- 238000001816 cooling Methods 0.000 claims description 23
- 238000010992 reflux Methods 0.000 claims description 23
- 240000007185 Albizia julibrissin Species 0.000 claims description 15
- 235000011468 Albizia julibrissin Nutrition 0.000 claims description 15
- 241000220433 Albizia Species 0.000 claims description 10
- 241000208966 Polygala Species 0.000 claims description 10
- 241000037488 Coccoloba pubescens Species 0.000 claims description 9
- 238000002137 ultrasound extraction Methods 0.000 claims description 9
- 241001165494 Rhodiola Species 0.000 claims description 8
- 238000000926 separation method Methods 0.000 claims description 8
- 238000002791 soaking Methods 0.000 claims description 8
- 238000000605 extraction Methods 0.000 claims description 7
- 239000011259 mixed solution Substances 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 abstract description 15
- 206010022437 insomnia Diseases 0.000 abstract description 15
- 230000000694 effects Effects 0.000 abstract description 14
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- 210000004185 liver Anatomy 0.000 abstract description 2
- 210000004072 lung Anatomy 0.000 abstract description 2
- 210000000952 spleen Anatomy 0.000 abstract description 2
- 240000000559 Albizia odoratissima Species 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 208000020016 psychiatric disease Diseases 0.000 abstract 1
- 239000002994 raw material Substances 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
- 241001065361 Gynostemma Species 0.000 description 21
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 208000010340 Sleep Deprivation Diseases 0.000 description 2
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- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 208000002720 Malnutrition Diseases 0.000 description 1
- 241000756042 Polygonatum Species 0.000 description 1
- 208000001431 Psychomotor Agitation Diseases 0.000 description 1
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- 208000007536 Thrombosis Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 229940125717 barbiturate Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229940049706 benzodiazepine Drugs 0.000 description 1
- 150000001557 benzodiazepines Chemical class 0.000 description 1
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- 206010013663 drug dependence Diseases 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000000147 hypnotic effect Effects 0.000 description 1
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- 230000001105 regulatory effect Effects 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 230000004622 sleep time Effects 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 208000011117 substance-related disease Diseases 0.000 description 1
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
- A61K36/424—Gynostemma
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/69—Polygalaceae (Milkwort family)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
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Abstract
The invention relates to the technical field of health products and traditional Chinese medicine combination, and discloses a traditional Chinese medicine combination medicine for improving sleep, gynostemma pentaphylla has the effects of calming, hypnotizing, improving human immunity and the like, rhodiola rosea can relieve pressure of people and adjust central nerves of people so as to improve sleep, rhodobryum roseum has the effects of nourishing heart, calming the nerves, clearing liver, improving eyesight and the like, albizia flower has the effects of resolving depression, calming the nerves, dispelling wind, improving eyesight, calming the heart, tranquilizing the mind and the like, and can be used for treating insomnia, amnesia, neurasthenia and the like, polygala tenuifolia has the effects of calming the nerves, improving intelligence, enhancing memory, resisting dementia, resisting aging and the like, polygonatum sibiricum has the effects of tonifying middle-jiao, replenishing qi, nourishing yin, tonifying spleen, moistening lung and the like, the extract liquid of various raw materials has synergistic effect, and the insomnia, caused by mental disorder, neurasthenia, palpitation and uneasiness and the, can be applied to the medicines for improving sleep and treating insomnia.
Description
Technical Field
The invention relates to the technical field of health-care product and traditional Chinese medicine combination, in particular to a traditional Chinese medicine combination medicine for improving sleep.
Background
The modern society has faster and faster life rhythm and increasingly fierce competition, so that people suffering from insomnia and anxiety are more and more, according to statistics, in developed countries, the proportion of insomnia people reaches 15-30%, in recent years, the number of people suffering from insomnia is gradually increased year by year, 20-30% of people suffer from insomnia with different degrees, the proportion of insomnia in the old population is higher than 40%, insomnia is a disease which can not obtain normal sleep due to mental malnutrition or restlessness, the clinical manifestations of the insomnia include insufficient sleep time, insufficient sleep depth, incapability of eliminating fatigue and the like, light people have difficulty in falling asleep or can not sleep soundly, and serious people can not sleep at night, so that people are tired, headache, dizziness, palpitation, amnesia and the like after waking, and the normal life work of people can be seriously influenced.
At present, the medicines for treating insomnia in the market are mainly synthetic medicines, and the western medicine mainly treats insomnia by using tranquilization and hypnosis medicines, such as benzodiazepines, barbiturates and the like, but the medicines have side effects such as dizziness, fatigue and the like after long-term use, and even influence memory, generate drug dependence and the like, so that natural plant medicines capable of promoting sleep need to be found.
Technical problem to be solved
Aiming at the defects of the prior art, the invention provides a traditional Chinese medicine composition for improving sleep, and solves the problems of lower efficiency and poorer safety of traditional Chinese medicine preparations for treating insomnia in the current market.
(II) technical scheme
In order to achieve the purpose, the invention provides the following technical scheme: a traditional Chinese medicine composition for improving sleep is prepared by the following steps:
(1) preparing a gynostemma pentaphylla extracting solution: pulverizing herba Gynostemmatis, sieving, placing the product in a reactor, adding 75% ethanol, soaking and extracting at 20-40 deg.C for 12-24 hr, and centrifuging to obtain herba Gynostemmatis extractive solution;
(2) preparing a rhodiola root extracting solution: pulverizing radix Rhodiolae, sieving, placing the product in a reactor, adding ethanol, performing ultrasonic extraction at 15-35 deg.C for 30-50min, and centrifuging to obtain radix Rhodiolae extractive solution;
(3) preparing a rhodobryum roseum extract: pulverizing and sieving the large leaf moss, putting the product into a reactor, adding deionized water, performing reflux extraction for 4-8h, cooling to room temperature, and performing centrifugal separation to obtain a large leaf moss extracting solution;
(4) preparing an albizzia flower extracting solution: pulverizing flos Albizziae, sieving, placing the product in a reactor, adding ethanol, reflux extracting for 4-6h, cooling to room temperature, and centrifuging to obtain flos Albizziae extract;
(5) preparing a polygala root extracting solution: pulverizing cortex et radix Polygalae, sieving, placing the product in a reactor, adding 70% ethanol, performing ultrasonic extraction at 300-400W for 30-50min, and centrifuging to obtain cortex et radix Polygalae extractive solution;
(6) preparing a sealwort extracting solution: pulverizing rhizoma Polygonati, sieving, placing the product in a reactor, adding deionized water, reflux extracting for 4-6h, cooling to room temperature, and centrifuging to obtain rhizoma Polygonati extract;
(7) adding herba Gynostemmatis extractive solution, radix Rhodiolae extractive solution, Large leaf Moss extractive solution, flos Albizziae extractive solution, cortex et radix Polygalae extractive solution, and rhizoma Polygonati extractive solution into reactor, ultrasonically dispersing uniformly, and concentrating to obtain Chinese medicinal composition for improving sleep.
Preferably, the mass ratio of the gynostemma pentaphylla to the 75% ethanol in the step (1) is 10: 80-120.
Preferably, the mass ratio of the rhodiola rosea to the ethanol in the step (2) is 10: 120-240.
Preferably, the mass ratio of the rhodobryum roseum to the deionized water in the step (3) is 10: 100-200.
Preferably, the mass ratio of the albizia julibrissin and the ethanol in the step (4) is 10: 150-.
Preferably, the mass ratio of polygala root to 70% ethanol in the step (5) is 10: 200-300.
Preferably, the mass ratio of the sealwort to the deionized water in the step (6) is 10: 80-120.
Preferably, the mass ratio of the gynostemma pentaphyllum extracting solution, the rhodiola rosea extracting solution, the rhodobryum roseum extracting solution, the albizia flower extracting solution, the polygala tenuifolia extracting solution and the polygonatum sibiricum extracting solution in the step (7) is 50-70:40-60:45-65:20-28:35-55: 100.
Preferably, the concentration in the step (7) is carried out under the condition that the mixed solution is concentrated into thick paste at 45-65 ℃.
(III) advantageous technical effects
Compared with the prior art, the invention has the following beneficial technical effects:
the gynostemma pentaphylla has the effects of reducing blood fat, blood sugar and blood pressure, resisting atherosclerosis, inhibiting thrombosis, tranquilizing, hypnotizing, improving human immunity and the like, the rhodiola rosea has the effects of tonifying qi, clearing away the lung-heat, nourishing the heart, promoting intelligence, tonifying qi, activating blood, promoting blood circulation, dredging collaterals, relieving asthma and the like, can relieve the pressure of people and regulate central nerves of people so as to improve sleep, the rhodobryum roseum has the effects of nourishing the heart, tranquilizing, clearing liver, improving eyesight and the like, the albizia julibrissin durazzini has the effects of relieving depression, calming the nerves, regulating qi, stimulating appetite and the like, can be used for treating insomnia, amnesia, stagnation, chest distress, neurasthenia and the like, has the effects of soothing the nerves, improving memory, resisting dementia, resisting aging, eliminating phlegm, reducing swelling and the like, and the polygonatum has the effects of tonifying spleen, tonifying qi, nourishing yin, moistening lung, tonifying kidney and the like The traditional Chinese medicine composition has no toxicity or dependence, and can be applied to medicines for improving sleep and treating insomnia.
Detailed Description
To achieve the above object, the present invention provides the following embodiments and examples: a traditional Chinese medicine composition for improving sleep is prepared by the following steps:
(1) preparing a gynostemma pentaphylla extracting solution: pulverizing herba Gynostemmatis, sieving, placing the product in a reactor, adding 75% ethanol at a mass ratio of 10:80-120, soaking and extracting at 20-40 deg.C for 12-24 hr, and centrifuging to obtain herba Gynostemmatis extractive solution;
(2) preparing a rhodiola root extracting solution: pulverizing radix Rhodiolae, sieving, placing the product in a reactor, adding ethanol at a mass ratio of radix Rhodiolae to ethanol of 10: 120-;
(3) preparing a rhodobryum roseum extract: crushing and sieving the large leaf moss, putting the product into a reactor, adding deionized water, wherein the mass ratio of the large leaf moss to the deionized water is 10:100-200, refluxing and extracting for 4-8h, cooling to room temperature, and performing centrifugal separation to obtain a large leaf moss extracting solution;
(4) preparing an albizzia flower extracting solution: pulverizing flos Albizziae, sieving, placing the product in a reactor, adding ethanol, wherein the mass ratio of flos Albizziae to ethanol is 10: 150-;
(5) preparing a polygala root extracting solution: pulverizing cortex et radix Polygalae, sieving, placing the product in a reactor, adding 70% ethanol at a mass ratio of cortex et radix Polygalae to 70% ethanol of 10: 200-;
(6) preparing a sealwort extracting solution: pulverizing rhizoma Polygonati, sieving, placing the product in a reactor, adding deionized water at a mass ratio of rhizoma Polygonati to deionized water of 10:80-120, reflux extracting for 4-6h, cooling to room temperature, and centrifuging to obtain rhizoma Polygonati extract;
(7) adding gynostemma pentaphylla extract, rhodiola rosea extract, rhodobryum roseum extract, albizia julibrissin durazzini extract, polygala tenuifolia extract and rhizoma polygonati extract into a reactor, wherein the mass ratio of the gynostemma pentaphylla extract to the rhodiola rosea extract to the rhodobryum roseum extract to the albizia julibrissin extract to the polygala tenuifolia extract to the polygonatum sibiricum extract is 50-70:40-60:45-65:20-28:35-55:100, uniformly dispersing by ultrasonic.
Example 1
(1) Preparing a gynostemma pentaphylla extracting solution: pulverizing herba Gynostemmatis, sieving, placing the product in a reactor, adding 75% ethanol at a mass ratio of 10:80, soaking and extracting at 20 deg.C for 12 hr, and centrifuging to obtain herba Gynostemmatis extract;
(2) preparing a rhodiola root extracting solution: pulverizing radix Rhodiolae, sieving, placing the product in a reactor, adding ethanol at a mass ratio of 10:120, performing ultrasonic extraction at 15 deg.C for 30min, and centrifuging to obtain radix Rhodiolae extractive solution;
(3) preparing a rhodobryum roseum extract: crushing and sieving the rhodobryum roseum, putting a product into a reactor, adding deionized water, performing reflux extraction for 4 hours, cooling to room temperature, and performing centrifugal separation to obtain a rhodobryum roseum extracting solution, wherein the mass ratio of the rhodobryum roseum to the deionized water is 10: 100;
(4) preparing an albizzia flower extracting solution: pulverizing flos Albizziae, sieving, placing the product in a reactor, adding ethanol at a mass ratio of flos Albizziae to ethanol of 10:150, reflux extracting for 4h, cooling to room temperature, and centrifuging to obtain flos Albizziae extract;
(5) preparing a polygala root extracting solution: pulverizing cortex et radix Polygalae, sieving, placing the product in a reactor, adding 70% ethanol at a mass ratio of 10:200, ultrasonic extracting at 300W for 30min, and centrifuging to obtain cortex et radix Polygalae extractive solution;
(6) preparing a sealwort extracting solution: pulverizing rhizoma Polygonati, sieving, placing the product in a reactor, adding deionized water at a mass ratio of rhizoma Polygonati to deionized water of 10:80, reflux extracting for 4h, cooling to room temperature, and centrifuging to obtain rhizoma Polygonati extract;
(7) adding gynostemma pentaphylla extract, rhodiola rosea extract, rhodobryum roseum extract, albizia julibrissin durazzini extract, polygala tenuifolia extract and rhizoma polygonati extract into a reactor, wherein the mass ratio of the gynostemma pentaphylla extract to the rhodiola rosea extract to the rhodobryum roseum extract to the albizia julibrissin extract to the polygala tenuifolia extract to the polygonatum sibiricum extract is 50:40:45:20:35:100, uniformly dispersing by.
Example 2
(1) Preparing a gynostemma pentaphylla extracting solution: pulverizing herba Gynostemmatis, sieving, placing the product in a reactor, adding 75% ethanol at a mass ratio of 10:90, soaking and extracting at 25 deg.C for 15 hr, and centrifuging to obtain herba Gynostemmatis extractive solution;
(2) preparing a rhodiola root extracting solution: pulverizing radix Rhodiolae, sieving, placing the product in a reactor, adding ethanol at a mass ratio of 10:150, performing ultrasonic extraction at 20 deg.C for 35min, and centrifuging to obtain radix Rhodiolae extractive solution;
(3) preparing a rhodobryum roseum extract: crushing and sieving the rhodobryum roseum, putting a product into a reactor, adding deionized water, performing reflux extraction for 5 hours, cooling to room temperature, and performing centrifugal separation to obtain a rhodobryum roseum extracting solution, wherein the mass ratio of the rhodobryum roseum to the deionized water is 10: 125;
(4) preparing an albizzia flower extracting solution: pulverizing flos Albizziae, sieving, placing the product in a reactor, adding ethanol at a mass ratio of flos Albizziae to ethanol of 10:175, reflux extracting for 4.5h, cooling to room temperature, and centrifuging to obtain flos Albizziae extract;
(5) preparing a polygala root extracting solution: pulverizing cortex et radix Polygalae, sieving, placing the product in a reactor, adding 70% ethanol at a mass ratio of 10:225, ultrasonic extracting at 325W for 35min, and centrifuging to obtain cortex et radix Polygalae extractive solution;
(6) preparing a sealwort extracting solution: pulverizing rhizoma Polygonati, sieving, placing the product in a reactor, adding deionized water at a mass ratio of rhizoma Polygonati to deionized water of 10:90, reflux extracting for 4.5h, cooling to room temperature, and centrifuging to obtain rhizoma Polygonati extract;
(7) adding gynostemma pentaphylla extract, rhodiola rosea extract, rhodobryum roseum extract, albizia julibrissin durazzini extract, polygala tenuifolia extract and rhizoma polygonati extract into a reactor, wherein the mass ratio of the gynostemma pentaphylla extract to the rhodiola rosea extract to the rhodobryum roseum extract to the albizia julibrissin extract to the polygala tenuifolia extract to the polygonatum sibiricum extract is 55:45:50:22:40:100, uniformly dispersing by.
Example 3
(1) Preparing a gynostemma pentaphylla extracting solution: pulverizing herba Gynostemmatis, sieving, placing the product in a reactor, adding 75% ethanol at a mass ratio of 10:100, soaking and extracting at 30 deg.C for 18h, and centrifuging to obtain herba Gynostemmatis extract;
(2) preparing a rhodiola root extracting solution: pulverizing radix Rhodiolae, sieving, placing the product in a reactor, adding ethanol at a mass ratio of 10:180, performing ultrasonic extraction at 25 deg.C for 40min, and centrifuging to obtain radix Rhodiolae extractive solution;
(3) preparing a rhodobryum roseum extract: crushing and sieving the rhodobryum roseum, putting a product into a reactor, adding deionized water, performing reflux extraction for 6 hours, cooling to room temperature, and performing centrifugal separation to obtain a rhodobryum roseum extracting solution, wherein the mass ratio of the rhodobryum roseum to the deionized water is 10: 150;
(4) preparing an albizzia flower extracting solution: pulverizing flos Albizziae, sieving, placing the product in a reactor, adding ethanol at a mass ratio of flos Albizziae to ethanol of 10:200, reflux extracting for 5h, cooling to room temperature, and centrifuging to obtain flos Albizziae extract;
(5) preparing a polygala root extracting solution: pulverizing cortex et radix Polygalae, sieving, placing the product in a reactor, adding 70% ethanol at a mass ratio of 10:250, ultrasonic extracting at 350W for 40min, and centrifuging to obtain cortex et radix Polygalae extractive solution;
(6) preparing a sealwort extracting solution: pulverizing rhizoma Polygonati, sieving, placing the product in a reactor, adding deionized water at a mass ratio of rhizoma Polygonati to deionized water of 10:100, reflux extracting for 5h, cooling to room temperature, and centrifuging to obtain rhizoma Polygonati extract;
(7) adding gynostemma pentaphylla extract, rhodiola rosea extract, rhodobryum roseum extract, albizia julibrissin durazzini extract, polygala tenuifolia extract and rhizoma polygonati extract into a reactor, wherein the mass ratio of the gynostemma pentaphylla extract to the rhodiola rosea extract to the rhodobryum roseum extract to the albizia julibrissin extract to the polygala tenuifolia extract to the polygonatum sibiricum extract is 60:50:55:24:45:100, uniformly dispersing by.
Example 4
(1) Preparing a gynostemma pentaphylla extracting solution: pulverizing Gynostemma pentaphyllum, sieving, placing the product in a reactor, adding 75% ethanol, soaking and extracting at 35 deg.C for 21h, and centrifuging to obtain Gynostemma pentaphyllum extractive solution, wherein the mass ratio of Gynostemma pentaphyllum to 75% ethanol is 10: 110;
(2) preparing a rhodiola root extracting solution: pulverizing radix Rhodiolae, sieving, placing the product in a reactor, adding ethanol at a mass ratio of 10:210, performing ultrasonic extraction at 30 deg.C for 45min, and centrifuging to obtain radix Rhodiolae extractive solution;
(3) preparing a rhodobryum roseum extract: crushing and sieving the rhodobryum roseum, putting the product into a reactor, adding deionized water, performing reflux extraction for 7 hours, cooling to room temperature, and performing centrifugal separation to obtain a rhodobryum roseum extracting solution, wherein the mass ratio of the rhodobryum roseum to the deionized water is 10: 175;
(4) preparing an albizzia flower extracting solution: pulverizing flos Albizziae, sieving, placing the product in a reactor, adding ethanol at a mass ratio of flos Albizziae to ethanol of 10:225, reflux extracting for 5.5h, cooling to room temperature, and centrifuging to obtain flos Albizziae extract;
(5) preparing a polygala root extracting solution: pulverizing cortex et radix Polygalae, sieving, placing the product in a reactor, adding 70% ethanol at a mass ratio of 10:275, ultrasonic extracting at 375W for 45min, and centrifuging to obtain cortex et radix Polygalae extractive solution;
(6) preparing a sealwort extracting solution: pulverizing rhizoma Polygonati, sieving, placing the product in a reactor, adding deionized water at a mass ratio of rhizoma Polygonati to deionized water of 10:110, reflux extracting for 5.5h, cooling to room temperature, and centrifuging to obtain rhizoma Polygonati extract;
(7) adding gynostemma pentaphylla extract, rhodiola rosea extract, rhodobryum roseum extract, albizia julibrissin durazzini extract, polygala tenuifolia extract and rhizoma polygonati extract into a reactor, wherein the mass ratio of the gynostemma pentaphylla extract to the rhodiola rosea extract to the rhodobryum roseum extract to the albizia julibrissin extract to the polygala tenuifolia extract to the polygonatum sibiricum extract is 65:55:60:26:50:100, uniformly dispersing by.
Example 5
(1) Preparing a gynostemma pentaphylla extracting solution: pulverizing herba Gynostemmatis, sieving, placing the product in a reactor, adding 75% ethanol at a mass ratio of 10:120, soaking and extracting at 40 deg.C for 24 hr, and centrifuging to obtain herba Gynostemmatis extractive solution;
(2) preparing a rhodiola root extracting solution: pulverizing radix Rhodiolae, sieving, placing the product in a reactor, adding ethanol at a mass ratio of 10:240, performing ultrasonic extraction at 35 deg.C for 50min, and centrifuging to obtain radix Rhodiolae extractive solution;
(3) preparing a rhodobryum roseum extract: crushing and sieving the rhodobryum roseum, putting a product into a reactor, adding deionized water, performing reflux extraction for 8 hours, cooling to room temperature, and performing centrifugal separation to obtain a rhodobryum roseum extracting solution, wherein the mass ratio of the rhodobryum roseum to the deionized water is 10: 200;
(4) preparing an albizzia flower extracting solution: pulverizing flos Albizziae, sieving, placing the product in a reactor, adding ethanol at a mass ratio of flos Albizziae to ethanol of 10:250, reflux extracting for 6h, cooling to room temperature, and centrifuging to obtain flos Albizziae extract;
(5) preparing a polygala root extracting solution: pulverizing cortex et radix Polygalae, sieving, placing the product in a reactor, adding 70% ethanol at a mass ratio of 10:300, ultrasonic extracting at 400W for 50min, and centrifuging to obtain cortex et radix Polygalae extractive solution;
(6) preparing a sealwort extracting solution: pulverizing rhizoma Polygonati, sieving, placing the product in a reactor, adding deionized water at a mass ratio of rhizoma Polygonati to deionized water of 10:120, reflux extracting for 6h, cooling to room temperature, and centrifuging to obtain rhizoma Polygonati extract;
(7) adding gynostemma pentaphylla extract, rhodiola rosea extract, rhodobryum roseum extract, albizia julibrissin durazzini extract, polygala tenuifolia extract and rhizoma polygonati extract into a reactor, wherein the mass ratio of the gynostemma pentaphylla extract to the rhodiola rosea extract to the rhodobryum roseum extract to the albizia julibrissin extract to the polygala tenuifolia extract to the polygonatum sibiricum extract is 70:60:65:28:55:100, uniformly dispersing by.
Claims (9)
1. A traditional Chinese medicine composition for improving sleep is characterized in that: the preparation method of the traditional Chinese medicine composition for improving sleep comprises the following steps:
(1) preparing a gynostemma pentaphylla extracting solution: pulverizing herba Gynostemmatis, sieving, placing the product in a reactor, adding 75% ethanol, soaking and extracting at 20-40 deg.C for 12-24 hr, and centrifuging to obtain herba Gynostemmatis extractive solution;
(2) preparing a rhodiola root extracting solution: pulverizing radix Rhodiolae, sieving, placing the product in a reactor, adding ethanol, performing ultrasonic extraction at 15-35 deg.C for 30-50min, and centrifuging to obtain radix Rhodiolae extractive solution;
(3) preparing a rhodobryum roseum extract: pulverizing and sieving the large leaf moss, putting the product into a reactor, adding deionized water, performing reflux extraction for 4-8h, cooling to room temperature, and performing centrifugal separation to obtain a large leaf moss extracting solution;
(4) preparing an albizzia flower extracting solution: pulverizing flos Albizziae, sieving, placing the product in a reactor, adding ethanol, reflux extracting for 4-6h, cooling to room temperature, and centrifuging to obtain flos Albizziae extract;
(5) preparing a polygala root extracting solution: pulverizing cortex et radix Polygalae, sieving, placing the product in a reactor, adding 70% ethanol, performing ultrasonic extraction at 300-400W for 30-50min, and centrifuging to obtain cortex et radix Polygalae extractive solution;
(6) preparing a sealwort extracting solution: pulverizing rhizoma Polygonati, sieving, placing the product in a reactor, adding deionized water, reflux extracting for 4-6h, cooling to room temperature, and centrifuging to obtain rhizoma Polygonati extract;
(7) adding herba Gynostemmatis extractive solution, radix Rhodiolae extractive solution, Large leaf Moss extractive solution, flos Albizziae extractive solution, cortex et radix Polygalae extractive solution, and rhizoma Polygonati extractive solution into reactor, ultrasonically dispersing uniformly, and concentrating to obtain Chinese medicinal composition for improving sleep.
2. The traditional Chinese medicine composition for improving sleep as claimed in claim 1, wherein: the mass ratio of the gynostemma pentaphylla to the 75% ethanol in the step (1) is 10: 80-120.
3. The traditional Chinese medicine composition for improving sleep as claimed in claim 1, wherein: the mass ratio of the rhodiola rosea to the ethanol in the step (2) is 10: 120-240.
4. The traditional Chinese medicine composition for improving sleep as claimed in claim 1, wherein: the mass ratio of the rhodobryum roseum to the deionized water in the step (3) is 10: 100-200.
5. The traditional Chinese medicine composition for improving sleep as claimed in claim 1, wherein: the mass ratio of the albizia flower to the ethanol in the step (4) is 10: 150-250.
6. The traditional Chinese medicine composition for improving sleep as claimed in claim 1, wherein: the mass ratio of the polygala root to 70% of ethanol in the step (5) is 10: 200-300.
7. The traditional Chinese medicine composition for improving sleep as claimed in claim 1, wherein: in the step (6), the mass ratio of the sealwort to the deionized water is 10: 80-120.
8. The traditional Chinese medicine composition for improving sleep as claimed in claim 1, wherein: in the step (7), the mass ratio of the gynostemma pentaphylla extract, the rhodiola rosea extract, the rhodobryum roseum extract, the albizia julibrissin flower extract, the polygala tenuifolia extract and the polygonatum sibiricum extract is 50-70:40-60:45-65:20-28:35-55: 100.
9. The traditional Chinese medicine composition for improving sleep as claimed in claim 1, wherein: the concentration condition in the step (7) is that the mixed solution is concentrated into thick paste at the temperature of 45-65 ℃.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105233023A (en) * | 2015-10-15 | 2016-01-13 | 安徽众禾药业股份有限公司 | Traditional Chinese medicine mixture with functions of neurasthenia treatment and sleep improvement |
| CN107485663A (en) * | 2017-08-04 | 2017-12-19 | 芜湖凯奥尔环保科技有限公司 | A kind of Flos Albiziae lavipeditum powder |
| CN108379357A (en) * | 2018-05-29 | 2018-08-10 | 广东省体育科学研究所 | It is a kind of to treat sleep disturbance compound Chinese medicinal preparation and preparation method thereof |
-
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- 2021-03-15 CN CN202110277794.6A patent/CN112741876A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105233023A (en) * | 2015-10-15 | 2016-01-13 | 安徽众禾药业股份有限公司 | Traditional Chinese medicine mixture with functions of neurasthenia treatment and sleep improvement |
| CN107485663A (en) * | 2017-08-04 | 2017-12-19 | 芜湖凯奥尔环保科技有限公司 | A kind of Flos Albiziae lavipeditum powder |
| CN108379357A (en) * | 2018-05-29 | 2018-08-10 | 广东省体育科学研究所 | It is a kind of to treat sleep disturbance compound Chinese medicinal preparation and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 邱蕾: "王振涛运用四参饮治疗快速心律失常经验", 《四川中医》 * |
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