CN112741865A - Medicine formula for treating esophagus cancer, preparation method and application - Google Patents

Abstract

The invention relates to the technical field of traditional Chinese medicines, and discloses a medicine formula for treating esophageal cancer, which comprises the following materials in parts by weight: 5-15 g of scorpio, 5-15 g of silkworm larva, 5-30 g of leech, 5-10 g of aspongopus, 10-30 g of eupolyphaga, 5-50 g of earthworm, 1-10 centipedes, 1-10 g of sal ammoniac, 3-5 g of arisaema cum bile, 10-30 g of lateral all-grass leaf, 3-45 g of garter snake, 3-5 g of toad skin, 5-4O g of cornu cervi degelatinatum, 5-10 g of gecko, 3-45 g of borneol, 5-3O g of marsdenia tenacissima, 3-50 g of clematis root, 5-5O g of magnet, 30-50 g of oldenlandia diffusa, 30-50 g of sculellaria barbata, 5-40 g of dark plum, 3-10 g of arisaema pentanatrum and 3-5 g of ice. The invention also provides a preparation method and application of the esophagus cancer treatment drug formula. The invention has the effects of dredging and purgation, promoting blood circulation and regulating qi, regulating qi and reducing phlegm, softening hard masses and removing blood stasis, and clearing away heat and toxic materials, and has obvious curative effect on treating esophageal tumors.

Description

Medicine formula for treating esophagus cancer, preparation method and application

Technical Field

The invention relates to the technical field of traditional Chinese medicines, in particular to a medicine formula for treating esophageal cancer, a preparation method and application.

Background

Cancer is one of the diseases that seriously endanger human life and health. The medical science thinks that when the human body is out of balance in acidity and alkalinity, namely the stability of the internal environment of the human body and the internal and external balance of the organism are damaged, carcinogenic factors can play a role to cause the formation of cancer, and the cancer can be infiltrated, diffused and transferred.

Esophageal cancer, also called esophageal tumor, is a malignant tumor that occurs in esophageal epithelial tissue. China is a high-incidence region of esophagus cancer, because death patients of the esophagus cancer are second to stomach cancer, the incidence age is more than 40 years old, men are more than women, and the incidence of the esophagus cancer is related to chronic stimulation of nitrosamine, inflammation and trauma, genetic factors and the content of trace elements in drinking water, food and vegetables. The symptoms of advanced esophageal cancer are marked by dysphagia, food reaction often occurs when the dysphagia is aggravated, the reflux amount is not large, and food and mucus are contained, and blood and pus can also be contained.

Although various medicines for treating the esophagus cancer exist at present, most medicines have poor effects, western medicines have large side effects on treating the esophagus cancer, no good Chinese patent medicine for treating the esophagus cancer exists, and the existing medicines for treating the esophagus cancer have high cost and few raw material sources and cannot meet the increasing needs of people in life.

Based on the defects in the prior art, the invention provides a medicine formula for treating esophageal cancer, a preparation method and application.

Disclosure of Invention

The invention provides a medicine formula for treating esophagus cancer, a preparation method and application, and aims to solve the problems in the background technology.

The invention provides a medicine formula for treating esophagus cancer, which comprises the following materials in parts by weight: 5-15 g of scorpio, 5-15 g of silkworm larva, 5-30 g of leech, 5-10 g of aspongopus, 10-30 g of eupolyphaga, 5-50 g of earthworm, 1-10 centipedes, 1-10 g of sal ammoniac, 3-5 g of arisaema cum bile, 10-30 g of lateral all-grass leaf, 3-45 g of garter snake, 3-5 g of toad skin, 5-4O g of cornu cervi degelatinatum, 5-10 g of gecko, 3-45 g of borneol, 5-3O g of marsdenia tenacissima, 3-50 g of clematis root, 5-5O g of magnet, 30-50 g of oldenlandia diffusa, 30-50 g of sculellaria barbata, 5-40 g of dark plum, 3-10 g of arisaema pentanatrum and 3-5 g of ice.

The invention also provides a preparation method of the esophagus cancer treatment drug formula, which comprises the following steps:

1) weighing the raw materials of the Chinese medicinal decoction pieces of scorpion, stiff silkworm, leech, aspongopus, dried body of ground beetle, earthworm, centipede, sal ammoniac, arisaema cum bile, lateral herbal leaves, garter snake, toad skin, cornu cervi degelatinatum, gecko, borneol, marsdenia tenacissima, clematis root, magnetite, spreading hedyotis herb, barbed skullcap herb, dark plum fruit, arisaema with five claws and ice lotus according to the weight for later use;

2) putting the weighed Chinese herbal pieces of the scorpion, the stiff silkworm, the leech, the aspongopus, the dried body of ground beetle, the earthworm, the centipede, the sal ammoniac, the arisaema cum bile, the lateral bark leaf of Chinese arborvitae, the garter snake, the toad skin, the cornu cervi degelatinatum, the gecko, the marsdenia tenacissima, the clematis root, the magnet, the oldenlandia diffusa, the sculellaria barbata, the dark plum and the arisaema cum bile into a medicine pot, and adding 2500 ml of water for soaking for;

3) boiling with strong fire, decocting with slow fire and concentrating to 600-.

The invention also provides application of the preparation method to preparation of the medicament, and the application adopts a drainage mode to feed the medicament to a patient once every three hours, and 3 to 5 milliliters of the medicament is fed each time.

The application can ensure that the esophagus tumor patient can swallow the medicament smoothly.

The function and the effect of each component of the invention are as follows:

the scorpion has the efficacies of calming endogenous wind, relieving spasm, counteracting toxic pathogen, dissipating stagnation, dredging collaterals and relieving pain. Can be used for treating pyocutaneous disease, toxic swelling, lymphoid tuberculosis, and tumor.

The Bombyx mori has the effects of reducing phlegm and resolving masses, and is used for treating sore throat, submandibular lymphadenitis and pruritus epidermis.

The leech has the functions of breaking blood and stimulating the menstrual flow, removing food retention and resolving powder, and reducing swelling and detoxifying, and is mainly used for treating tissue blood stasis obstruction, innominate toxic swelling and scrofula because the leech contains hirudin and protein in vivo and has the effects of resisting coagulation and breaking blood stasis.

Aspongopus has high content of anticancer and cancer suppressing elements manganese and magnesium in vivo, and low content of cancer elements nickel, chromium, arsenic, cadmium and beryllium, and has anticancer effect.

Eupolyphaga Seu Steleophaga has effects of removing blood stasis. Can be used for treating swelling and pain due to blood stasis, and amenorrhea due to blood stasis.

Lumbricus, has effects of clearing heat, stopping endogenous wind, dredging collaterals, relieving asthma, and lowering blood pressure. It can be used for treating qi deficiency, blood stagnation, arthralgia syndrome, pain, carbuncle, swelling, and skin ulcer.

Scolopendra has effects of calming endogenous wind, relieving spasm, counteracting toxic substances, resolving hard mass, dredging collaterals, and relieving pain. Can be used for treating pyocutaneous disease, toxic swelling, scrofula, and tuberculosis.

Sal Ammoniacus has effects of resolving food stagnation, softening hard masses, eliminating slough, promoting granulation, and eliminating phlegm. Can be used for treating swelling and pain of tissue, carbuncle, scrofula, polyp, and wart.

Arisaema cum bile has effects of clearing pathogenic fire, eliminating phlegm, relieving convulsion and arresting epilepsy. Can be used for clearing away heat, eliminating phlegm, relieving cough due to phlegm-heat, and eliminating yellow and thick phlegm. ,

all leaves of Chinese arborvitae herb have the effects of cooling blood, stopping bleeding, reducing phlegm and relieving cough. It can be used for treating hemorrhage due to blood heat, hematemesis, and epistaxis.

Zaocys dhumnades has the effects of dispelling wind, dredging collaterals and relieving spasm. It is mainly used for scrofula and malignant sore.

The cutis Bufonis has effects of removing toxic substances and relieving pain. It is used to treat carbuncle, cellulitis, furuncle, scrofula, and sore throat.

Cornu Cervi Degelatinatum has astringent and hemostatic effects. It is indicated for unhealing sores and ulcers.

Borneol has the effects of dredging orifices, dispelling stagnated fire, and relieving swelling and pain. Can be used for treating pharyngitis, aphtha, carbuncle, swelling, and hemorrhoid.

Marsdenia tenacissima has the effects of relieving cough and asthma, eliminating phlegm, and clearing away heat and toxic materials. It can be used for treating cough, asthma, excessive phlegm, swelling and pain, sore, and carbuncle.

The clematis root has the effects of expelling wind-damp, dredging collaterals, relieving pain and eliminating bone sticking. It can be used for treating throat and phlegm retention of bone carp.

Magnetitum has effects of relieving convulsion, tranquilizing mind, and promoting inspiration and relieving asthma. It is mainly used for treating restlessness of heart-mind and palpitation.

Oldenlandia diffusa has the effects of clearing away heat and toxic materials, promoting diuresis and treating stranguria. It is mainly used for treating carbuncle, swelling, sore throat, and pain due to heat stranguria.

The barbed skullcap herb has the effects of clearing away heat and toxic materials, dissipating blood stasis, stopping bleeding, inducing diuresis and reducing edema. It can be used for treating carbuncle, swelling, sore throat, scrofula, hematemesis, epistaxis, stranguria with blood, edema, and cancer.

Dark plum has the effects of promoting the production of body fluid and calming roundworms. Can be used for treating chronic cough due to lung deficiency, and diabetes due to deficiency heat.

The rhizoma arisaematis has the effects of dispelling wind and relieving spasm, and resolving phlegm and resolving masses. It is mainly indicated for wind-phlegm accumulation, cough with excessive phlegm, abscess and scrofula.

The Mentholum also called Mentholum has effects of stimulating skin mucosa, relieving itching, diminishing inflammation, relieving pain, and cooling topical part. It is used clinically in treating pain, inflammation and swelling.

Aiming at the disease causes of esophagus tumor patients, such as emaciation, pale yellow face, impotence fistula, dull complexion, epigastric distending pain, abdominal fullness and chest distension, slow and weak pulse, pale tongue with thin and white fur, liver qi discomfort, qi stagnation and stasis, dysphagia, pain after breastbone, spleen deficiency and dysfunction, qi stagnation and blood stasis, chest diaphragm retention, hiccup and chest pain, according to the formula, the pharmacology of scorpion, stiff silkworm, leech, aspongopus, dried body of ground beetle, earthworm, centipede, sal ammoniac, arisaema cum bile, lateral herbal leaves, garter snake, toad skin, cornu cervi degelatinatum, gecko, borneol, marsdenia tenacissima, clematis root, magnet, oldenlandia diffusa, barbed skullcap herb, dark plum, arisaema cum bile and lotus ice can be used for strengthening body resistance, clearing and purgation, activating blood circulation and regulating qi, eliminating phlegm, softening hard mass and clearing heat, so as to detoxify, the toxic materials, the tumor has the function of gradually dispelling atrophy function under the condition without operation, so that the tumor is gradually cleared up, Softening and improving the quality. The treatment has obvious effect.

The long-term administration of patients proves that the traditional Chinese medicine composition has the effects of dredging purgation, promoting blood circulation and regulating qi, regulating qi to reduce phlegm, softening hardness and removing blood stasis, and clearing heat and removing toxicity, has unique curative effect on treating esophageal tumors, has no side effect symptom, is low in treatment cost, adopts a drainage mode, and is convenient for patients to take.

Detailed Description

The invention is further illustrated by the following examples.

Example 1

The invention provides a medicine formula for treating esophagus cancer, which comprises the following materials in parts by weight: 10 g of scorpion, 15 g of silkworm, 20 g of leech, 0 g of aspongopus, 20 g of eupolyphaga, 30 g of earthworm, 5 centipedes, 5 g of sal ammoniac, 3 g of arisaema cum bile, 20 g of laterally-rolled BAIYE, 30 g of garter snake, 3 g of toad crisp skin, 30 g of cornu cervi degelatinatum, 5 g of gecko, 30 g of borneol, 20 g of marsdenia tenacissima, 10 g of radix clematidis, 30 g of magnet, 30 g of oldenlandia diffusa, 30 g of barbed skullcap herb, 20 g of dark plum, 6 g of rhizoma arisaematis, and 3 g of ice lotus leaf.

The preparation method of the medicine formula for treating the esophagus cancer comprises the following steps:

1) weighing the raw materials of the Chinese medicinal decoction pieces of scorpion, stiff silkworm, leech, aspongopus, dried body of ground beetle, earthworm, centipede, sal ammoniac, arisaema cum bile, lateral herbal leaves, garter snake, toad skin, cornu cervi degelatinatum, gecko, borneol, marsdenia tenacissima, clematis root, magnetite, spreading hedyotis herb, barbed skullcap herb, dark plum fruit, arisaema with five claws and ice lotus according to the weight for later use;

2) putting the weighed Chinese herbal pieces of the scorpion, the stiff silkworm, the leech, the aspongopus, the dried body of ground beetle, the earthworm, the centipede, the sal ammoniac, the arisaema cum bile, the lateral bark leaf of Chinese arborvitae, the garter snake, the toad skin, the cornu cervi degelatinatum, the gecko, the marsdenia tenacissima, the clematis root, the magnet, the oldenlandia diffusa, the sculellaria barbata, the dark plum and the arisaema cum bile into a medicine pot, and adding 2500 ml;

3) boiling with strong fire, decocting with slow fire, concentrating to 650 ml, adding Borneolum Syntheticum and Mentholum, decocting with slow fire, concentrating to 600 ml, stopping fire, cooling to room temperature, and pouring out the medicinal liquid to obtain the final product.

The medicament prepared by the preparation method is applied by feeding the medicament to a patient in a drainage mode, and the medicament is fed once every three hours, and 3 to 5 milliliters of the medicament is fed each time.

The patient's king and prescription is good for patients who have been taken from Zhao county hospital in 2019, the patients have a diagnosis due to poor appetite, the patients have emaciation, pale yellow face, withered and fistula and gray and dark skin color, and the patients are diagnosed as esophageal cancer by Zhao county hospital and four hospitals in Hebei province in 2019, the hospitals are arranged to perform surgical treatment, the patients are afraid of surgery and seek the traditional Chinese medicine treatment along with the change, the patients are taken by the receiving and taking method, the symptoms are improved every three hours and 3 to 5 milliliters every time, the patients can swallow liquid food, the patients are taken at intervals, the esophageal tumor atrophy disappears after the hospital is rechecked, the communication is smooth, and the patients are healthy up to now.

Example 2

The invention provides a medicine formula for treating esophagus cancer, which comprises the following materials in parts by weight: 5 g of scorpion, 5 g of silkworm, 5 g of leech, 5 g of aspongopus, 10 g of eupolyphaga, 5 g of earthworm, 1 centipede, 5 g of sal ammoniac, 3 g of arisaema cum bile, 10 g of cacumen biotae, 3 g of garter snake, 5 g of toad crisp skin, 5 g of cornu cervi degelatinatum, 5 g of gecko, 3 g of borneol, 5 g of marsdenia tenacissima, 3 g of radix clematidis, 5 g of magnetite, 30 g of oldenlandia diffusa, 30 g of barbed skullcap herb, 5 g of dark plum, 3 g of arisaema cum bile and 3 g of ice lotus leaf.

The preparation method of the medicine formula for treating the esophagus cancer comprises the following steps:

1) weighing the raw materials of the Chinese medicinal decoction pieces of scorpion, stiff silkworm, leech, aspongopus, dried body of ground beetle, earthworm, centipede, sal ammoniac, arisaema cum bile, lateral herbal leaves, garter snake, toad skin, cornu cervi degelatinatum, gecko, borneol, marsdenia tenacissima, clematis root, magnetite, spreading hedyotis herb, barbed skullcap herb, dark plum fruit, arisaema with five claws and ice lotus according to the weight for later use;

2) putting the weighed Chinese herbal pieces of the scorpion, the stiff silkworm, the leech, the aspongopus, the dried body of ground beetle, the earthworm, the centipede, the sal ammoniac, the arisaema cum bile, the lateral bark leaf of Chinese arborvitae, the garter snake, the toad skin, the cornu cervi degelatinatum, the gecko, the marsdenia tenacissima, the clematis root, the magnet, the oldenlandia diffusa, the sculellaria barbata, the dark plum and the arisaema cum bile into a medicine pot, and adding 2500 ml;

3) boiling with strong fire, decocting with slow fire, concentrating to 650 ml, adding Borneolum Syntheticum and Mentholum, decocting with slow fire, concentrating to 600 ml, stopping fire, cooling to room temperature, and pouring out the medicinal liquid to obtain the final product.

The medicament prepared by the preparation method is applied by feeding the medicament to a patient in a drainage mode, and the medicament is fed once every 0.5 hour and 3 to 5 milliliters each time.

Patients are subjected to xx, 72-year-old men, Zhao county front major chapter villagers, 1 month and 24 days of 1999, first visit, medical record abstracts, drinking and perusal, excessive mental stress, sadness for several months, and disharmony between family life, so that chest distress, distending pain, epigastric fullness after meals, intermittent medication, no curative effect, occasional choking and stagnation of food intake in the near term, smooth porridge, blockage of dried rice, chronic mouth and throat eating, and the symptoms of the patients are accompanied by gastric cavity distending pain, abdominal fullness, chest distension, slow and weak pulse and thin and white tongue fur.

Dialectical, stomach ache, liver qi discomfort, qi stagnation and depression.

Therapeutic method, unblocking purgation, softening hardness to remove blood stasis, activating blood and regulating qi.

After the patient receives a follow-up diagnosis 1 month and 29 days in 1999, the food-intake obstruction disappears, the patient can heal the disease and stop taking the medicine for two days by himself, the symptom has recurrence, the swallowing infarction recurrence is shown, the cardiac tube is narrow by about 3.5 cm and has irregular edge through barium swallowing fluoroscopy in the hospital, and the cardiac cancer is diagnosed as early cardiac cancer through the abnormal change of the barium preparation.

Three diagnosis methods No. 4 in 2 months and 4 in 1999, the patient who has a flowing porridge and has hard eating is difficult to take, and the symptoms are relieved by taking the traditional Chinese medicine with the regulation and treatment method, and the symptoms are obviously relieved.

Example 3

The invention provides a medicine formula for treating esophagus cancer, which comprises the following raw materials in parts by weight: 5 g of scorpion, 5 g of silkworm, 5 g of leech, 5 g of aspongopus, 10 g of eupolyphaga, 10 g of earthworm, 5 centipede, 5 g of sal ammoniac, 3 g of nayun, 10 g of cacumen biotae, 10 g of zaocys dhumnade, 5 g of toad spider skin, 10 g of cornu cervi degelatinatum, 10 g of jiangdynasty emperor, 3 g of borneol, 10 g of marsdenia tenacissima, 10 g of radix clematidis, 10 g of magnetite, 30 g of oldenlandia diffusa, 30 g of barbed skullcap herb, 10 g of dark plum, 3 g of arisaema with five claws and 5 g of ice lotus leaf.

The preparation method of the medicine formula for treating the esophagus cancer comprises the following steps:

1) weighing the raw materials of the Chinese medicinal decoction pieces of scorpion, stiff silkworm, leech, aspongopus, dried body of ground beetle, earthworm, centipede, sal ammoniac, arisaema cum bile, lateral herbal leaves, garter snake, toad skin, cornu cervi degelatinatum, gecko, borneol, marsdenia tenacissima, clematis root, magnetite, spreading hedyotis herb, barbed skullcap herb, dark plum fruit, arisaema with five claws and ice lotus according to the weight for later use;

2) putting the weighed Chinese herbal pieces of the scorpion, the stiff silkworm, the leech, the aspongopus, the dried body of ground beetle, the earthworm, the centipede, the sal ammoniac, the arisaema cum bile, the lateral bark leaf of Chinese arborvitae, the garter snake, the toad skin, the cornu cervi degelatinatum, the gecko, the marsdenia tenacissima, the clematis root, the magnet, the oldenlandia diffusa, the sculellaria barbata, the dark plum and the arisaema cum bile into a medicine pot, and adding 2500 ml;

3) boiling with strong fire, decocting with slow fire, concentrating to 650 ml, adding Borneolum Syntheticum and Mentholum, decocting with slow fire, concentrating to 600 ml, stopping fire, cooling to room temperature, and pouring out the medicinal liquid to obtain the final product.

The medicament prepared by the preparation method is applied by feeding the medicament to a patient in a drainage mode, and the medicament is fed once every 0.5 hour and 3 to 5 milliliters each time.

The patient king X, male, 70 years old, Zhao county Zhao State town person, case overview, 5 months 1997, patient self-induced dysphagia with poststernal pain, 3 months and 14 lines of gastroscopy in 1998, infiltration type cancer at the lower end of esophagus < about 4.2 cm > pathology < esophagus biopsy see small cancer cell >, patient refuses operation, and the patient takes the traditional Chinese medicine for regulation in 98 years, symptoms disappear, diet is as usual, and the treatment is as yet, and the curative effect is good.

The treatment process is carried out, the initial diagnosis is carried out in 1998.3.14 days, patients complain, dysphagia occurs in three months, only liquid diet is carried out, pain occurs after sternum, emaciation and hypodynamia are caused, the pulse is deep and thin, the tongue coating is thin and white,

the syndrome is marked by spleen deficiency and transportation failure, qi stagnation and blood stasis, chest obstruction, hiccup, food and chest pain, and the treatment is planned to dredge purgation, clear heat and remove toxicity, and counteract toxicity with toxicity.

The traditional Chinese medicine is taken slowly after being taken for 3 milliliters every half an hour.

The medicament has good effect of treating more than half a month, can obviously relieve symptoms after being continuously taken for more than one year, can eat cooked rice, has no obstruction feeling, has no side effect and has good spirit.

The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.

Claims (3)

1. The formula of the medicine for treating the esophagus cancer is characterized by comprising the following materials in parts by weight: 5-15 g of scorpio, 5-15 g of silkworm larva, 5-30 g of leech, 5-10 g of aspongopus, 10-30 g of eupolyphaga, 5-50 g of earthworm, 1-10 centipedes, 1-10 g of sal ammoniac, 3-5 g of arisaema cum bile, 10-30 g of lateral all-grass leaf, 3-45 g of garter snake, 3-5 g of toad skin, 5-4O g of cornu cervi degelatinatum, 5-10 g of gecko, 3-45 g of borneol, 5-3O g of marsdenia tenacissima, 3-50 g of clematis root, 5-5O g of magnet, 30-50 g of oldenlandia diffusa, 30-50 g of sculellaria barbata, 5-40 g of dark plum, 3-10 g of arisaema pentanatrum and 3-5 g of ice.

2. A method for preparing the pharmaceutical formulation for treating esophageal cancer according to claim 1, comprising the steps of:

1) weighing the raw materials of the Chinese medicinal decoction pieces of scorpion, stiff silkworm, leech, aspongopus, dried body of ground beetle, earthworm, centipede, sal ammoniac, arisaema cum bile, lateral herbal leaves, garter snake, toad skin, cornu cervi degelatinatum, gecko, borneol, marsdenia tenacissima, clematis root, magnetite, spreading hedyotis herb, barbed skullcap herb, dark plum fruit, arisaema with five claws and ice lotus according to the weight for later use;

2) putting the weighed Chinese herbal pieces of the scorpion, the stiff silkworm, the leech, the aspongopus, the dried body of ground beetle, the earthworm, the centipede, the sal ammoniac, the arisaema cum bile, the lateral bark leaf of Chinese arborvitae, the garter snake, the toad skin, the cornu cervi degelatinatum, the gecko, the marsdenia tenacissima, the clematis root, the magnet, the oldenlandia diffusa, the sculellaria barbata, the dark plum and the arisaema cum bile into a medicine pot, and adding 2500 ml of water for soaking for;

3) boiling with strong fire, decocting with slow fire and concentrating to 600-.

3. Use of the preparation according to claim 2 for administration to a patient in a drainage manner, wherein the administration is carried out once every 0.5-3 hours, 3-5 ml each time.