CN112741797A - Oral care toothpaste containing periplaneta americana extract and preparation method thereof - Google Patents
Oral care toothpaste containing periplaneta americana extract and preparation method thereof Download PDFInfo
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
The invention discloses oral care toothpaste containing periplaneta americana extract and a preparation method thereof, wherein the oral care toothpaste comprises the following raw materials in percentage by mass: 0.6-3.5% of periplaneta americana extract, 25-40% of a humidity regulator, 0.5-2.5% of a thickening agent, 0.01-0.3% of a sweetening agent, 1-3% of a foaming agent, 0.6-1.2% of an essence, 40-50% of an abrasive, 0.01-0.03% of a preservative, 0.01-0.03% of an antibacterial agent and the balance of deionized water, wherein the total amount of the components is 100%. A certain amount of periplaneta americana extract and an antibacterial agent are added into a basic formula of the toothpaste, and the periplaneta americana extract and the antibacterial agent can generate a synergistic effect, so that the prepared toothpaste has the effects of removing dental plaque, preventing and improving oral inflammation, preventing and stopping dental caries and effectively relieving pain and inhibiting bacteria; in addition, the abrasive is compounded by adopting the specific proportion of calcium carbonate and active nano-scale micro-silica powder, so that dirt on the surfaces of teeth and between teeth can be removed in the process of tooth brushing, and incomplete oral cleaning is avoided.
Description
Technical Field
The invention relates to an oral cleaning and nursing product and the technical field of production thereof, in particular to an oral nursing toothpaste containing periplaneta americana extract.
Background
Oral inflammation is a common disease, such as periodontitis, gingivitis, periodontal abscess, and maxillofacial space infection, which is not fatal, but causes physiological pain and psychological impact to humans. Dental caries, commonly known as decayed tooth, is a progressive lesion of hard tooth tissue. It is expressed as inorganic demineralization and organic matter decomposition. The currently accepted etiology of dental caries is the four-in-one theory, which mainly includes bacteria, oral environment, host and time. The occurrence of dental caries may further cause problems such as tooth loss or discoloration, decrease in masticatory function, and pulposis. Western medicines are mainly used for treating oral inflammation clinically, and although the method is quick in effect, bacteria can generate drug resistance.
The toothpaste is an indispensable oral cavity cleaning and nursing article in daily life of people, and has the basic functions of cleaning teeth, refreshing breath and protecting the oral cavity health. Along with the increasing health care consciousness of consumers, more requirements are put forward on toothpaste, and besides tooth cleaning, the toothpaste also has the functions of assisting in preventing oral diseases and having nursing and health care effects on the oral cavity. In recent years, with the development of the modernization technology of traditional Chinese medicines, the method for researching and utilizing the active ingredients of the traditional Chinese medicines is well developed, which provides good technical support for the toothpaste to assist in preventing oral diseases by utilizing the active ingredients of the traditional Chinese medicines.
Periplaneta americana belongs to the family Blattaria and is one of the three dominant species of Blatta. The periplaneta americana extract is clinically used for treating diseases such as scalds, burns, cardiovascular diseases and the like. The research shows that the periplaneta americana has the effects of resisting bacteria and inflammation, relieving swelling and pain, promoting tissue repair and enhancing immunity. The extract has strong inhibiting effect on gram-positive bacteria and gram-negative bacteria, so that bacteria in deep layer of bacterial plaque are inhibited during growth and reproduction, and the extract has certain preventing and treating effect on dental caries.
Disclosure of Invention
The invention aims to provide an oral care toothpaste of periplaneta americana extract and a preparation method thereof, and the prepared toothpaste has the effects of removing bacterial plaque, effectively preventing and improving oral inflammation, preventing and stopping dental caries, reducing tartar, relieving pain and resisting bacteria.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows:
the invention provides an oral care toothpaste containing periplaneta americana extract on one hand, which comprises the following raw materials in percentage by mass:
0.6-3.5% of periplaneta americana extract, 25-40% of a humidity regulator, 0.5-2.5% of a thickening agent, 0.01-0.3% of a sweetening agent, 1-3% of a foaming agent, 0.6-1.2% of an essence, 40-50% of an abrasive, 0.01-0.03% of a preservative, 0.01-0.03% of an antibacterial agent and the balance of deionized water, wherein the total amount of the components is 100%.
As a preferable scheme, the humidity regulator comprises sorbitol and polyethylene glycol-8, and the mass ratio of the sorbitol to the polyethylene glycol-8 is 2: 1.
as a preferable scheme, the thickening agent comprises cellulose gum and xanthan gum, and the mass ratio of the cellulose gum to the xanthan gum is 1: 1.
as a preferred embodiment, the sweetener is saccharin sodium.
As a preferable scheme, the foaming agent comprises sodium lauryl sulfate and potassium lauroyl sarcosinate, and the mass ratio of the sodium lauryl sulfate to the potassium lauroyl sarcosinate is (1.5-2): 1.
as a preferred scheme, the essence is mint essence and comprises the following components in percentage by mass: 35% of menthol, 25% of ethyl menthane carboxamide, 8.5% of eucalyptus oil, 16.5% of fennel oil, 4% of clove oil, 8.9% of spearmint oil, 2% of cinnamon oil and 0.1% of vanillin.
As a preferable scheme, the abrasive comprises calcium carbonate and active nano-scale silica fume, and the mass ratio of the calcium carbonate to the active nano-scale silica fume is 5: 1, the mass percentage of silicon dioxide in the active nano-scale micro silicon powder is 85-99%, and the average particle size of the active nano-scale micro silicon powder is 0.02-0.4 μm.
As a preferred scheme, the preservative comprises methyl hydroxybenzoate and sodium benzoate, and the mass ratio of methyl hydroxybenzoate to sodium benzoate is 1: 1, the methyl hydroxybenzoate is methyl p-hydroxybenzoate, and the antibacterial agent is cetylpyridinium chloride.
As a preferred scheme, the periplaneta americana extract is obtained by extracting the following steps:
(1) after crushing the dried periplaneta americana, carrying out degreasing treatment by using petroleum ether to obtain degreased periplaneta americana powder;
(2) adding 90% ethanol into defatted Periplaneta americana powder, stirring, sealing, placing in a percolation cylinder after the powder is fully expanded, adding 10 times of 90% ethanol, soaking for 50h, percolating at the speed of 2mL/min/kg, and collecting filtrate;
(3) concentrating the obtained filtrate under reduced pressure at 56 deg.C under vacuum degree of-0.06 MPa, and stopping concentrating until the relative density is 1.13 to obtain concentrated solution;
(4) adding deionized water 6 times the weight of the concentrated solution into the concentrated solution, heating to 50 deg.C, stirring for 25min, standing for 12 hr, cooling to 12 deg.C, standing for 22 hr, separating the solution, filtering to obtain filtrate with a filter pore diameter of 5 μm;
(5) performing column chromatography by using HP20 macroporous adsorbent resin;
(6) concentrating the obtained eluate under reduced pressure at 48 deg.C and vacuum degree of-0.06 MPa until the relative density is 1.28, and stopping concentration to obtain extract;
(7) and (3) putting the extract into a freeze drying tray, transferring the extract into a vacuum freeze dryer, dehydrating the material at the temperature of minus 35 ℃ and under the pressure of 2Pa, and freeze-drying for 30 hours to obtain the periplaneta americana extract.
The invention provides a preparation method of oral care toothpaste containing the periplaneta americana extract on the other hand, which comprises the following steps:
(1) weighing the following raw materials in percentage by mass:
0.6-3.5% of periplaneta americana extract, 25-40% of humidity regulator, 0.5-2.5% of thickener, 0.01-0.3% of sweetening agent, 1-3% of foaming agent, 0.6-1.2% of essence, 40-50% of abrasive, 0.01-0.03% of preservative, 0.01-0.03% of antibacterial agent and the balance of deionized water, wherein the total amount of the components is 100%;
(2) adding a humidity regulator into the thickener, uniformly dispersing, adding deionized water, uniformly mixing, heating to 80-90 ℃, keeping for 10-20 min to fully expand the thickener, and then cooling to 40 ℃ to obtain a mixed solution;
(3) adding sweetener, foaming agent, abrasive, antiseptic, and antibacterial agent into the obtained mixture, and stirring to obtain mixture;
(4) adding the periplaneta Americana extract and essence into the obtained mixture, stirring for 15-25 min, and standing and aging for 6h to obtain an aged substance;
(5) grinding the aged substance until no hard particulate matter is detected, vacuumizing to vacuum degree of not less than-0.096 Mpa, bottling, and inspecting to obtain oral care toothpaste containing Periplaneta americana extract.
Has the advantages that:
(1) according to the invention, a certain amount of periplaneta americana extract is added, so that the prepared toothpaste can effectively prevent oral inflammation and decayed teeth and can repair oral ulcer;
(2) the abrasive agent is prepared by mixing calcium carbonate and active nano-grade silica fume in a mass ratio of 5: 1, the two ingredients can remove dental calculus comprehensively under the synergistic effect, and the effect is particularly better for yellowing and fouling of the teeth of smokers. On one hand, the calcium carbonate and the toothbrush play roles simultaneously, so that dirt on the surface of teeth can be removed, and tooth stain is relieved; on the other hand, dirt and yellow precipitate in the tooth gaps act with the micro silicon powder in the tooth brushing process, so that the problem of incomplete oral cleaning can be avoided;
(3) the antibacterial agent cetylpyridinium chloride is added, and the antibacterial agent cetylpyridinium chloride can generate a synergistic enhancement effect with the periplaneta americana extract, so that the prepared toothpaste has better antibacterial, bacteriostatic and anti-inflammatory effects, and the stomatitis is effectively slowed down.
Detailed Description
The invention will be further understood by reference to the following detailed description of preferred embodiments of the invention and the examples included therein. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. To the extent that a definition of a particular term disclosed in the prior art is inconsistent with any definition provided in the present disclosure, the definition of the term provided in the present disclosure controls.
As used herein, a feature that does not define a singular or plural form is also intended to include a plural form of the feature unless the context clearly indicates otherwise. It will be further understood that the term "prepared from …," as used herein, is synonymous with "comprising," including, "comprising," "having," "including," and/or "containing," when used in this specification means that the recited composition, step, method, article, or device is present, but does not preclude the presence or addition of one or more other compositions, steps, methods, articles, or devices. Furthermore, the use of "preferred," "preferably," "more preferred," etc., when describing embodiments of the present invention, is meant to refer to embodiments of the invention that may provide certain benefits, under certain circumstances. However, other embodiments may be preferred, under the same or other circumstances. In addition, the recitation of one or more preferred embodiments does not imply that other embodiments are not useful, nor is it intended to exclude other embodiments from the scope of the invention.
In order to achieve the purpose, the invention provides an oral care toothpaste containing periplaneta americana extract on one hand, which comprises the following raw materials in percentage by mass:
0.6-3.5% of periplaneta americana extract, 25-40% of a humidity regulator, 0.5-2.5% of a thickening agent, 0.01-0.3% of a sweetening agent, 1-3% of a foaming agent, 0.6-1.2% of an essence, 40-50% of an abrasive, 0.01-0.03% of a preservative, 0.01-0.03% of an antibacterial agent and the balance of deionized water, wherein the total amount of the components is 100%.
In some preferred embodiments, the humidity regulator comprises sorbitol and polyethylene glycol-8, wherein the mass ratio of the sorbitol to the polyethylene glycol-8 is 2: 1. it can make the prepared toothpaste smooth, uniform and bright, and also can keep the toothpaste stable, prevent the volatilization of water, and make the toothpaste not dry, hard and hard, and difficult to squeeze.
In some preferred embodiments, the thickener comprises cellulose gum and xanthan gum in a mass ratio of 1: 1.
the cellulose gum is one of sodium carboxymethylcellulose (CMC), Methylcellulose (MC), Ethylcellulose (EC), Methylethylcellulose (MEC), Hydroxyethylcellulose (HEC) and Hydroxypropylcellulose (HPC), and more preferably, the cellulose gum is sodium carboxymethylcellulose (CMC).
In some preferred embodiments, the sweetener is saccharin sodium.
In some preferred embodiments, the foaming agent comprises sodium lauryl sulfate and potassium lauroyl sarcosinate, and the mass ratio of the sodium lauryl sulfate to the potassium lauroyl sarcosinate is (1.5-2): 1, more preferably, the mass ratio of the two is 1.8: 1.
in some preferred embodiments, the essence is a mint essence, and consists of the following components in percentage by mass: 35% of menthol, 25% of ethyl menthane carboxamide, 8.5% of eucalyptus oil, 16.5% of fennel oil, 4% of clove oil, 8.9% of spearmint oil, 2% of cinnamon oil and 0.1% of vanillin.
In some preferred embodiments, the abrasive agent comprises calcium carbonate and active nano-scale silica fume, and the mass ratio of the calcium carbonate to the active nano-scale silica fume is 5: 1, the mass percentage of silicon dioxide in the active nano-scale micro silicon powder is 85-99%, and the average particle size of the active nano-scale micro silicon powder is 0.02-0.4 μm.
Calcium carbonate can work in conjunction with a toothbrush to remove food soils and plaque remaining on the tooth surface, providing a cleaning function.
However, food scraps and dirt are easy to remain on parts such as slits between teeth which are difficult to brush, stubborn dental plaque can be formed over time, the micro silica powder has extremely high surface activity and extremely fine granularity, the dirt deposited in the slits between the teeth in the tooth brushing process and the interaction of yellow precipitate and micro silica powder particles can effectively remove the dirt of the teeth, the teeth are clean and white, the tooth cleaning effect of people who smoke for a long time is better, the oral cavity of people is fresh and smooth under the action of auxiliary ingredients of the toothpaste, and the added active micro silica powder is completely nontoxic active materials, so that the prepared toothpaste is safe and nontoxic. Through the synergistic effect of calcium carbonate and silicon powder, the prepared toothpaste can completely and thoroughly remove tartar without residue, thereby avoiding the generation of stomatitis.
In some preferred embodiments, the preservative comprises methyl hydroxybenzoate and sodium benzoate, and the mass ratio of methyl hydroxybenzoate to sodium benzoate is 1: 1, the methyl hydroxybenzoate is methyl p-hydroxybenzoate, and the antibacterial agent is cetylpyridinium chloride.
In some preferred embodiments, the periplaneta americana extract is extracted by the following method:
(1) after crushing the dried periplaneta americana, carrying out degreasing treatment by using petroleum ether to obtain degreased periplaneta americana powder;
(2) adding 90% ethanol into defatted Periplaneta americana powder, stirring, sealing, placing in a percolation cylinder after the powder is fully expanded, adding 10 times of 90% ethanol, soaking for 50h, percolating at the speed of 2mL/min/kg, and collecting filtrate;
(3) concentrating the obtained filtrate under reduced pressure at 56 deg.C under vacuum degree of-0.06 MPa, and stopping concentrating until the relative density is 1.13 to obtain concentrated solution;
(4) adding deionized water 6 times the weight of the concentrated solution into the concentrated solution, heating to 50 deg.C, stirring for 25min, standing for 12 hr, cooling to 12 deg.C, standing for 22 hr, separating the solution, filtering to obtain filtrate with a filter pore diameter of 5 μm;
(5) performing column chromatography by using HP20 macroporous adsorbent resin;
(6) concentrating the obtained eluate under reduced pressure at 48 deg.C and vacuum degree of-0.06 MPa until the relative density is 1.28, and stopping concentration to obtain extract;
(7) and (3) putting the extract into a freeze drying tray, transferring the extract into a vacuum freeze dryer, dehydrating the material at the temperature of minus 35 ℃ and under the pressure of 2Pa, and freeze-drying for 30 hours to obtain the periplaneta americana extract.
The invention provides a preparation method of oral care toothpaste containing the periplaneta americana extract on the other hand, which comprises the following steps:
(1) weighing the following raw materials in percentage by mass:
0.6-3.5% of periplaneta americana extract, 25-40% of humidity regulator, 0.5-2.5% of thickener, 0.01-0.3% of sweetening agent, 1-3% of foaming agent, 0.6-1.2% of essence, 40-50% of abrasive, 0.01-0.03% of preservative, 0.01-0.03% of antibacterial agent and the balance of deionized water, wherein the total amount of the components is 100%;
(2) adding a humidity regulator into the thickener, uniformly dispersing, adding deionized water, uniformly mixing, heating to 80-90 ℃, keeping for 10-20 min to fully expand the thickener, and then cooling to 40 ℃ to obtain a mixed solution;
(3) adding sweetener, foaming agent, abrasive, antiseptic, and antibacterial agent into the obtained mixture, and stirring to obtain mixture;
(4) adding the periplaneta Americana extract and essence into the obtained mixture, stirring for 15-25 min, and standing and aging for 6h to obtain an aged substance;
(5) grinding the aged substance until no hard particulate matter is detected, vacuumizing to vacuum degree of not less than-0.096 Mpa, bottling, and inspecting to obtain oral care toothpaste containing Periplaneta americana extract.
Examples
The liquid components used in the present invention, not specifically indicated, are all commercially available technical grade products.
The solid components used in the present invention, which are not specifically described, are commercially available industrial-grade products.
The periplaneta americana extracts referred to in the examples were extracted by the following method:
(1) after crushing the dried periplaneta americana, carrying out degreasing treatment by using petroleum ether to obtain degreased periplaneta americana powder;
(2) adding 90% ethanol into defatted Periplaneta americana powder, stirring, sealing, placing in a percolation cylinder after the powder is fully expanded, adding 10 times of 90% ethanol, soaking for 50h, percolating at the speed of 2mL/min/kg, and collecting filtrate;
(3) concentrating the obtained filtrate under reduced pressure at 56 deg.C under vacuum degree of-0.06 MPa, and stopping concentrating until the relative density is 1.13 to obtain concentrated solution;
(4) adding deionized water 6 times the weight of the concentrated solution into the concentrated solution, heating to 50 deg.C, stirring for 25min, standing for 12 hr, cooling to 12 deg.C, standing for 22 hr, separating the solution, filtering to obtain filtrate with a filter pore diameter of 5 μm;
(5) performing column chromatography by using HP20 macroporous adsorbent resin;
(6) concentrating the obtained eluate under reduced pressure at 48 deg.C and vacuum degree of-0.06 MPa until the relative density is 1.28, and stopping concentration to obtain extract;
(7) and (3) putting the extract into a freeze drying tray, transferring the extract into a vacuum freeze dryer, dehydrating the material at the temperature of minus 35 ℃ and under the pressure of 2Pa, and freeze-drying for 30 hours to obtain the periplaneta americana extract.
Example 1
The embodiment provides an oral care toothpaste containing periplaneta americana extract on one hand, which comprises the following raw materials in percentage by mass:
3.0% of periplaneta americana extract, 20% of sorbitol, 10% of polyethylene glycol, 1% of sodium carboxymethylcellulose (CMC), 1% of xanthan gum, 0.1% of saccharin sodium, 1.8% of sodium lauryl sulfate, 1% of potassium lauroyl sarcosinate, 0.8% of essence, 40% of calcium carbonate, 8% of silicon powder, 0.01% of methyl p-hydroxybenzoate, 0.01% of sodium benzoate, 0.02% of cetylpyridinium chloride and the balance of deionized water.
The essence is mint essence and comprises the following components in percentage by mass: 35% of menthol, 25% of ethyl menthane carboxamide, 8.5% of eucalyptus oil, 16.5% of fennel oil, 4% of clove oil, 8.9% of spearmint oil, 2% of cinnamon oil and 0.1% of vanillin.
The invention provides a preparation method of oral care toothpaste containing the periplaneta americana extract on the other hand, which comprises the following steps:
(1) weighing the raw materials according to the proportion, and respectively storing for later use;
(2) adding sorbitol and polyethylene glycol-8 into sodium carboxymethylcellulose (CMC) and xanthan gum, uniformly dispersing, adding deionized water, uniformly mixing, heating to 85 deg.C, maintaining for 15min to make the CMC and xanthan gum fully expand, and cooling to 40 deg.C to obtain mixed solution;
(3) adding saccharin sodium, sodium lauryl sulfate, potassium lauroyl sarcosinate, calcium carbonate, active nanometer-level silica fume, methyl p-hydroxybenzoate, sodium benzoate, and cetylpyridinium chloride into the obtained mixed solution, and stirring to obtain mixture;
(4) adding Periplaneta americana extract and herba Menthae essence into the obtained mixture, stirring for 20min, standing and aging for 6h to obtain aged substance;
(5) grinding the aged substance until no hard particulate matter is detected, vacuumizing to vacuum degree of not less than-0.096 Mpa, bottling, and inspecting to obtain oral care toothpaste containing Periplaneta americana extract.
Example 2
The embodiment provides an oral care toothpaste containing periplaneta americana extract on one hand, which comprises the following raw materials in percentage by mass:
2.4% of periplaneta americana extract, 26% of sorbitol, 13% of polyethylene glycol, 1.2% of sodium carboxymethylcellulose (CMC), 1.2% of xanthan gum, 0.05% of saccharin sodium, 2% of sodium lauryl sulfate, 1% of potassium lauroyl sarcosinate, 1% of essence, 35% of calcium carbonate, 7% of silicon powder, 0.015% of methyl p-hydroxybenzoate, 0.015% of sodium benzoate, 0.03% of cetylpyridinium chloride and the balance of deionized water.
The essence is mint essence and comprises the following components in percentage by mass: 35% of menthol, 25% of ethyl menthane carboxamide, 8.5% of eucalyptus oil, 16.5% of fennel oil, 4% of clove oil, 8.9% of spearmint oil, 2% of cinnamon oil and 0.1% of vanillin.
The invention provides a preparation method of oral care toothpaste containing the periplaneta americana extract on the other hand, which comprises the following steps:
(1) weighing the raw materials according to the proportion, and respectively storing for later use;
(2) adding sorbitol and polyethylene glycol-8 into sodium carboxymethylcellulose (CMC) and xanthan gum, uniformly dispersing, adding deionized water, uniformly mixing, heating to 80 deg.C, maintaining for 20min to make the CMC and xanthan gum fully expand, and cooling to 40 deg.C to obtain mixed solution;
(3) adding saccharin sodium, sodium lauryl sulfate, potassium lauroyl sarcosinate, calcium carbonate, active nanometer-level silica fume, methyl p-hydroxybenzoate, sodium benzoate, and cetylpyridinium chloride into the obtained mixed solution, and stirring to obtain mixture;
(4) adding Periplaneta americana extract and herba Menthae essence into the obtained mixture, stirring for 25min, standing and aging for 6h to obtain aged substance;
(5) grinding the aged substance until no hard particulate matter is detected, vacuumizing to vacuum degree of not less than-0.096 Mpa, bottling, and inspecting to obtain oral care toothpaste containing Periplaneta americana extract.
Example 3
The embodiment provides an oral care toothpaste containing periplaneta americana extract on one hand, which comprises the following raw materials in percentage by mass:
0.8% of periplaneta americana extract, 18% of sorbitol, 9% of polyethylene glycol, 0.9% of sodium carboxymethylcellulose (CMC), 0.9% of xanthan gum, 0.2% of saccharin sodium, 1.8% of sodium lauryl sulfate, 0.9% of potassium lauroyl sarcosinate, 0.7% of essence, 40% of calcium carbonate, 8% of silicon powder, 0.01% of methyl p-hydroxybenzoate, 0.01% of sodium benzoate, 0.01% of cetylpyridinium chloride and the balance of deionized water.
The essence is mint essence and comprises the following components in percentage by mass: 35% of menthol, 25% of ethyl menthane carboxamide, 8.5% of eucalyptus oil, 16.5% of fennel oil, 4% of clove oil, 8.9% of spearmint oil, 2% of cinnamon oil and 0.1% of vanillin.
The invention provides a preparation method of oral care toothpaste containing the periplaneta americana extract on the other hand, which comprises the following steps:
(1) weighing the raw materials according to the proportion, and respectively storing for later use;
(2) adding sorbitol and polyethylene glycol-8 into sodium carboxymethylcellulose (CMC) and xanthan gum, uniformly dispersing, adding deionized water, uniformly mixing, heating to 90 deg.C, maintaining for 10min to make the CMC and xanthan gum fully expand, and cooling to 40 deg.C to obtain mixed solution;
(3) adding saccharin sodium, sodium lauryl sulfate, potassium lauroyl sarcosinate, calcium carbonate, active nanometer-level silica fume, methyl p-hydroxybenzoate, sodium benzoate, and cetylpyridinium chloride into the obtained mixed solution, and stirring to obtain mixture;
(4) adding Periplaneta americana extract and herba Menthae essence into the obtained mixture, stirring for 15min, standing and aging for 6h to obtain aged substance;
(5) grinding the aged substance until no hard particulate matter is detected, vacuumizing to vacuum degree of not less than-0.096 Mpa, bottling, and inspecting to obtain oral care toothpaste containing Periplaneta americana extract.
Comparative example 1
The comparative example provides an oral care toothpaste containing periplaneta americana extract and a preparation method thereof, and is different from example 1 in that the periplaneta americana extract is 0.5% by mass.
Comparative example 2
The comparative example provides an oral care toothpaste containing periplaneta americana extract and a method for preparing the same, which is different from example 1 in that an antibacterial agent is not added.
Bacteriostasis test
The toothpaste containing periplaneta americana extracts prepared in examples 1-3 and comparative examples 1-2 acted on streptococcus mutans and lactobacillus (the main pathogenic bacteria of dental caries).
The test steps are as follows: enrichment culture is carried out, then 1g of the toothpaste prepared in examples 1-3 and comparative examples 1-2 is added respectively, and the number of bacteria before and after comparison is detected through 2min of oscillation.
The test results are shown in Table 1.
TABLE 1 evaluation of bacteriostatic results
As can be seen from the test results in Table 1, the toothpaste prepared in examples 1 to 3 has an excellent bacteriostatic effect on Streptococcus mutans and Lactobacillus, and the highest bacteriostatic rate can reach 91.25%. From the test results of the comparative examples, it can be seen that: when the addition amount of the periplaneta americana extract is not within the optimal proportion range specified by the invention, the bacteriostatic effect is deteriorated; when the antibacterial agent cetylpyridinium chloride is not added, the prepared toothpaste has poor antibacterial effect.
Although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that modifications and variations can be made in the present invention without departing from the spirit and scope of the invention as defined by the appended claims.
Claims (10)
1. The oral care toothpaste containing the periplaneta americana extract is characterized by comprising the following raw materials in percentage by mass: 0.6-3.5% of periplaneta americana extract, 25-40% of a humidity regulator, 0.5-2.5% of a thickening agent, 0.01-0.3% of a sweetening agent, 1-3% of a foaming agent, 0.6-1.2% of an essence, 40-50% of an abrasive, 0.01-0.03% of a preservative, 0.01-0.03% of an antibacterial agent and the balance of deionized water, wherein the total amount of the components is 100%.
2. The oral care toothpaste containing periplaneta americana extract according to claim 1, wherein the humectant comprises sorbitol and polyethylene glycol-8 in a mass ratio of 2: 1.
3. the oral care toothpaste containing periplaneta americana extract according to claim 1, wherein the thickener comprises cellulose gum and xanthan gum in a mass ratio of 1: 1.
4. the oral care toothpaste containing periplaneta americana extract according to claim 1, wherein the sweetener is sodium saccharin.
5. The oral care toothpaste containing the periplaneta americana extract as claimed in claim 1, wherein the foaming agent comprises sodium lauryl sulfate and potassium lauroyl sarcosinate, and the mass ratio of the sodium lauryl sulfate to the potassium lauroyl sarcosinate is (1.5-2): 1.
6. the oral care toothpaste containing the periplaneta americana extract according to claim 1, wherein the essence is mint essence and comprises the following components in percentage by mass: 35% of menthol, 25% of ethyl menthane carboxamide, 8.5% of eucalyptus oil, 16.5% of fennel oil, 4% of clove oil, 8.9% of spearmint oil, 2% of cinnamon oil and 0.1% of vanillin.
7. The oral care toothpaste containing the periplaneta americana extract as claimed in claim 1, wherein the abrasive comprises calcium carbonate and active nano-scale silica fume, and the mass ratio of the calcium carbonate to the active nano-scale silica fume is 5: 1, the mass percentage of silicon dioxide in the active nano-scale micro silicon powder is 85-99%, and the average particle size of the active nano-scale micro silicon powder is 0.02-0.4 μm.
8. The oral care toothpaste containing periplaneta americana extract as claimed in claim 1, wherein the preservative comprises methyl hydroxybenzoate and sodium benzoate, and the mass ratio of methyl hydroxybenzoate to sodium benzoate is 1: 1, the methyl hydroxybenzoate is methyl p-hydroxybenzoate, and the antibacterial agent is cetylpyridinium chloride.
9. The oral care toothpaste containing the periplaneta americana extract as claimed in claim 1, wherein the periplaneta americana extract is extracted by the following method:
(1) after crushing the dried periplaneta americana, carrying out degreasing treatment by using petroleum ether to obtain degreased periplaneta americana powder;
(2) adding 90% ethanol into defatted Periplaneta americana powder, stirring, sealing, placing in a percolation cylinder after the powder is fully expanded, adding 10 times of 90% ethanol, soaking for 50h, percolating at the speed of 2mL/min/kg, and collecting filtrate;
(3) concentrating the obtained filtrate under reduced pressure at 56 deg.C under vacuum degree of-0.06 MPa, and stopping concentrating until the relative density is 1.13 to obtain concentrated solution;
(4) adding deionized water 6 times the weight of the concentrated solution into the concentrated solution, heating to 50 deg.C, stirring for 25min, standing for 12 hr, cooling to 12 deg.C, standing for 22 hr, separating the solution, filtering to obtain filtrate with a filter pore diameter of 5 μm;
(5) performing column chromatography by using HP20 macroporous adsorbent resin;
(6) concentrating the obtained eluate under reduced pressure at 48 deg.C and vacuum degree of-0.06 MPa until the relative density is 1.28, and stopping concentration to obtain extract;
(7) and (3) putting the extract into a freeze drying tray, transferring the extract into a vacuum freeze dryer, dehydrating the material at the temperature of minus 35 ℃ and under the pressure of 2Pa, and freeze-drying for 30 hours to obtain the periplaneta americana extract.
10. A method for preparing the periplaneta americana extract-containing oral care toothpaste according to any one of claims 1 to 9, comprising the steps of:
(1) weighing the following raw materials in percentage by mass:
0.6-3.5% of periplaneta americana extract, 25-40% of humidity regulator, 0.5-2.5% of thickener, 0.01-0.3% of sweetening agent, 1-3% of foaming agent, 0.6-1.2% of essence, 40-50% of abrasive, 0.01-0.03% of preservative, 0.01-0.03% of antibacterial agent and the balance of deionized water, wherein the total amount of the components is 100%;
(2) adding a humidity regulator into the thickener, uniformly dispersing, adding deionized water, uniformly mixing, heating to 80-90 ℃, keeping for 10-20 min to fully expand the thickener, and then cooling to 40 ℃ to obtain a mixed solution;
(3) adding sweetener, foaming agent, abrasive, antiseptic, and antibacterial agent into the obtained mixture, and stirring to obtain mixture;
(4) adding the periplaneta Americana extract and essence into the obtained mixture, stirring for 15-25 min, and standing and aging for 6h to obtain an aged substance;
(5) grinding the aged substance until no hard particulate matter is detected, vacuumizing to vacuum degree of not less than-0.096 Mpa, bottling, and inspecting to obtain oral care toothpaste containing Periplaneta americana extract.
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