CN112741089A - Bacteriostatic mite-killing spray for children and preparation method thereof - Google Patents

Abstract

The invention relates to the technical field of bacteriostatic mite-killing spraying agents, and particularly relates to a children type bacteriostatic mite-killing spraying agent and a preparation method thereof. A bacteriostatic mite-killing spray for children comprises the following raw materials in parts by weight: 90.15-96.15 parts of the component A; 4.35-8.35 parts of a component B; 0.3-0.7 part of a component C; the raw materials of the component A comprise water and a stabilizer; the raw materials of the component B comprise a humectant, a freshener, a preservative and a surfactant; the raw material of the component C comprises a bacteriostatic mite-killing agent which is a mixture of phenoxyethanol and ethylhexyl glycerin. The invention provides a children type bacteriostatic mite-killing spray, which takes a bacteriostatic mite-killing agent and a freshener as main bacteriostatic, mite-killing and mite-expelling effective components, can kill mites and bacteria in a simple spraying mode, and is suitable for children.

Description

Bacteriostatic mite-killing spray for children and preparation method thereof

Technical Field

The invention relates to the technical field of bacteriostatic mite-killing spraying agents, and particularly relates to a children type bacteriostatic mite-killing spraying agent and a preparation method thereof.

Background

Mites are widely distributed in dark corners of a room, carpets, mattresses, pillows, sofas, air conditioners, summer sleeping mats and the like, wherein the mattresses are most suitable for the growth and propagation of the mites. Allergic diseases caused by mites mainly comprise allergic rhinitis, allergic conjunctivitis, allergic asthma and allergic dermatitis, which can affect the daily work and life of patients, and even endanger life of serious patients. Generally, mites, mainly dust mites, which belong to arachnids, in a domestic environment were found to be allergic to house dust mites and dust mites in an allergen survey of 583 patients with allergic rhinitis in 72.6% and 68.8%, respectively. The method is more suitable for breeding dust mites in the environment with the annual average temperature of 20 ℃ and the humidity of more than 70 percent in south, so that the density of the mites in the cities in south and middle east of China is obviously higher than that in the cities in north.

Aiming at the characteristics of dust mites and the harm caused by the dust mites, the number of mite removing products on the market is correspondingly increased in recent years, besides a mite removing instrument adopting a physical method, various chemical mite removing products such as a mite removing bag, a mite removing laundry detergent and the like are sufficient, wherein pyrethroid insecticides can effectively remove mites, pyrethrins refer to pyrethroid medicines and are compounds simulating the synthesis of pyrethrins, and therefore the chemical components are generally ended by a 'pyrethroid' double letter. The dimethyl propane carboxylic ester is commonly called bifenthrin and also has good mite killing effect. However, pyrethrin has certain harm to human body, the harm is mainly reflected in stimulation to skin, eye, nose and throat mucous membrane, and even has some effect on human nerves in severe cases, so people can feel dizzy and uncomfortable, and especially children are more harmed.

In addition, there is a large group of products for alleviateing the plants to remove and repel mites. In fact, the essential oil and other components contained in many plants do have the function of expelling and even killing mites, but the content of the essential oil and other components is required to be high enough, and meanwhile, the essential oil components have volatility, and the mite expelling effect is greatly reduced along with the gradual reduction of the content after volatilization. Therefore, chemically synthesized active ingredients are still the mainstream in order to effectively and long-lasting acaricidal or even acaricidal action. Therefore, the search for a product which has stable properties, is safe, efficient, low in toxicity, can quickly remove mites and is suitable for children becomes an urgent problem to be solved.

Disclosure of Invention

The invention aims to overcome at least one defect of the prior art and provides a child type bacteriostatic mite-killing spray which is used for solving the problem that the existing pyrethroid insecticides for killing mites have great harm to children.

The invention also provides a preparation method of the children type bacteriostatic mite-killing spray.

The technical scheme adopted by the invention is as follows:

a bacteriostatic mite-killing spray for children comprises the following raw materials in parts by weight: 90.15-96.15 parts of the component A; 4.35-8.35 parts of a component B; 0.3-0.7 part of a component C; the raw materials of the component A comprise water and a stabilizer; the raw materials of the component B comprise a humectant, a freshener, a preservative and a surfactant; the raw material of the component C comprises a bacteriostatic mite-killing agent which is a mixture of phenoxyethanol and ethylhexyl glycerin.

According to the technical scheme, the A, B, C components are combined to obtain the child type bacteriostatic mite-killing spray which can be used in dark corners of rooms, carpets, mattresses, pillows, sofas, air conditioners, summer sleeping mats and the like, and bacterial growth can be inhibited and mites can be removed in a simple spraying mode. The technical scheme takes the bacteriostatic mite-killing agent and the freshener as main bacteriostatic, mite-killing and mite-expelling effective components, and on the basis, the property stability and long-term effectiveness of the bacteriostatic mite-killing spray are kept by adding the stabilizer, the humectant, the preservative and the surfactant. In the technical scheme, phenoxyethanol as an insect repellent and an external disinfectant has special bacteriostasis to pseudomonas aeruginosa, gram-positive bacteria and gram-negative bacteria, has high efficiency, broad spectrum, low toxicity, no allergy and irritation, is suitable for children, and does not have the condition that drug residues similar to pyrethroid insecticides harm human bodies; the ethylhexyl glycerin has excellent deodorization effect, and can inhibit the growth and reproduction of bacteria generating peculiar smell; the phenoxyethanol and the ethylhexyl glycerin are compounded, and the effect of alcohols is promoted by the ethylhexyl glycerin, so that the bacteriostatic and acarid-removing effect of the spray of the technical scheme is further improved, and the effect is better than that of the spray of the phenoxyethanol and the ethylhexyl glycerin when the phenoxyethanol and the ethylhexyl glycerin are used alone.

Preferably, the paint also comprises 0.1-0.3 part of a D component, wherein the D component raw material comprises 3-aryl propionate and Derivatives (3-Arylpropionate Derivatives) thereof.

More preferably, the 3-aryl propionate derivative comprises methyl 3-phenylpropionate or ethyl 3-phenylpropionate. The research of the prior art shows that cinnamic acid and cinnamic acid ester which is a derivative thereof have a certain mite removing effect. The prior art also has a technical scheme of using cinnamic acid to prepare the mite removing agent, but even though cinnamic acid belongs to a natural compound, toxic and side effects can still be caused when the content is increased for improving the mite removing effect. Therefore, the application of cinnamic acid and cinnamate in mite killing in the prior art is still limited. 3-phenylpropionic acid is a dihydro derivative of cinnamic acid, the ester of which is widely found in plants. However, the present inventors have conducted studies on 3-phenylpropionic acid, and have found that 3-phenylpropionic acid ester, which is a derivative of cinnamate, has a better mite-removing effect. Specifically, methyl 3-phenylpropionate is more effective. Therefore, on the basis, the D component which is 3-aryl propionate and derivatives thereof is added by the inventor, so that the mite removing effect of the mite removing spray is further improved. And has sufficient safety due to natural components. In addition, the compound has higher mite removing property than cinnamate or derivatives thereof, so that the compound can effectively reduce the dosage and further improve the safety, and is suitable for people including children.

Preferably, the component A comprises the following raw materials in parts by weight: 91.1-95.1 parts of water; 0.03-0.07 part of stabilizer.

Preferably, the component B comprises the following raw materials in parts by weight: 4-6 parts of a humectant; 0.05-0.15 part of a freshener; 0.1-0.2 part of preservative; 0.8-1.4 parts of surfactant.

Preferably, the component C comprises the following raw materials in parts by weight: 0.4-0.6 part of bacteriostatic acarid-removing agent.

Preferably, in the antibacterial mite-killing agent, the weight part ratio of the phenoxyethanol to the ethylhexyl glycerin is 9: 1.

preferably, the stabilizer is disodium EDTA and/or the humectant is methyl propylene glycol.

Preferably, the freshener is menthol and/or the preservative is o-cymene-5-ol. In the technical scheme, the menthol is used as a freshener and can achieve the mite expelling effect to a certain extent, the menthol expels mites through smell, and the existence of the menthol smell can reduce the regeneration of the mites and keep the long-term effect of mite killing in the place sprayed by the spraying agent. The o-cymene-5-alcohol component is an antifungal preservative, so that the effect of prolonging the shelf life of the product can be achieved, and the mite removing spray of the technical scheme is not easy to expire. In addition, the ethyl hexyl glycerol can also promote the anti-corrosion performance of the o-cymene-5-alcohol extraction, so that the product is more durable.

Preferably, the surfactant comprises water, propylene glycol, nonylphenol polyether-14, PEG-50 castor oil, the water: propylene glycol: polyether-14 phenol: the weight portion ratio of the PEG-50 castor oil is 6: 5: 5: 4.

a preparation method of a children type bacteriostatic mite-killing spray comprises the following steps:

s1, adding the component A into a container, and fully stirring until the component A is completely dissolved;

s2, preheating the component B, fully stirring until the component B is completely dissolved, and then adding the component B into the component A;

s3, adding the component C, fully stirring and uniformly mixing;

s4, detecting the semi-finished product, and filtering and discharging after the semi-finished product is qualified;

s5, storing;

and S6, filling, packaging and warehousing.

Compared with the prior art, the invention has the beneficial effects that: the invention provides a children type bacteriostatic mite-killing spray, which takes a bacteriostatic mite-killing agent and a freshener as main bacteriostatic, mite-killing and mite-expelling effective components, can kill mites and bacteria in a simple spraying mode, and is suitable for children. Meanwhile, the invention provides a preparation method of the children type bacteriostatic mite-killing spray, which is simple in process and easy to prepare.

Drawings

Fig. 1 is a flow chart of a preparation method of the bacteriostatic mite-killing spray for children in example 1.

Detailed Description

The drawings are only for purposes of illustration and are not to be construed as limiting the invention. For a better understanding of the following embodiments, certain features of the drawings may be omitted, enlarged or reduced, and do not represent the size of an actual product; it will be understood by those skilled in the art that certain well-known structures in the drawings and descriptions thereof may be omitted.

Examples

A bacteriostatic mite-killing spray for children comprises the following raw materials in parts by weight: 90.15-96.15 parts of the component A; 4.35-8.35 parts of a component B; 0.3-0.7 part of a component C; the raw materials of the component A comprise water and a stabilizer; the raw materials of the component B comprise a humectant, a freshener, a preservative and a surfactant; the raw material of the component C comprises a bacteriostatic mite-killing agent which is a mixture of phenoxyethanol and ethylhexyl glycerin. Further, the raw material of the component A comprises 91.1-95.1 parts of water; 0.03-0.07 part of a stabilizer; the raw material of the component B comprises 4-6 parts of a humectant; 0.05-0.15 part of a freshener; 0.1-0.2 part of preservative; 0.8-1.4 parts of surfactant, and the raw material of the component C comprises 0.4-0.6 part of bacteriostatic acarid-removing agent. In the bacteriostatic mite-killing agent, the weight part ratio of phenoxyethanol to ethylhexyl glycerin is 9: 1. the stabilizer is EDTA-disodium and/or the humectant is methyl propylene glycol. The freshener is menthol and/or the preservative is o-cymene-5-ol. The surfactant comprises water, propylene glycol, nonyl phenol polyether-14 and PEG-50 castor oil, wherein the weight ratio of the water: propylene glycol: polyether-14 phenol: the weight portion ratio of the PEG-50 castor oil is 6: 5: 5: 4.

according to the embodiment, the A, B, C components are combined to obtain the children type bacteriostatic mite-killing spray which can be used in dark corners of rooms, carpets, mattresses, pillows, sofas, air conditioners, summer sleeping mats and the like, and can inhibit bacterial growth and remove mites in a simple spraying manner. The embodiment takes the bacteriostatic mite-killing agent and the freshener as main bacteriostatic, mite-killing and mite-expelling effective components, and on the basis, the property stability and long-term effectiveness of the bacteriostatic mite-killing spray are maintained by adding the stabilizer, the humectant, the preservative and the surfactant. In the embodiment, phenoxyethanol as an insect repellent and an external disinfectant has specific bacteriostasis on pseudomonas aeruginosa, has bacteriostasis on gram-positive bacteria and gram-negative bacteria, has high efficiency, broad spectrum, low toxicity, no allergy and irritation, is suitable for children, and does not have the situation that drug residues similar to pyrethroid insecticides harm human bodies; the ethylhexyl glycerin has excellent deodorization effect, and can inhibit the growth and reproduction of bacteria generating peculiar smell; the phenoxyethanol and the ethylhexyl glycerin are compounded, and the effect of alcohols is promoted by the ethylhexyl glycerin, so that the bacteriostatic and acarid-removing effect of the spraying agent is further improved, and the effect is better than that of the spraying agent which is used alone. In the embodiment, the menthol is used as a freshener and can achieve an acarid expelling effect to a certain extent, the menthol expels acarids through smell, and the existence of the smell of the menthol can reduce the regeneration of the acarids and keep the long-term effect of acarids elimination in the place sprayed by the spraying agent. The o-cymene-5-alcohol component is an antifungal preservative, so that the effect of prolonging the shelf life of the product can be achieved, and the mite removing spray of the embodiment is not easy to expire. In addition, the ethyl hexyl glycerol can also promote the anti-corrosion performance of the o-cymene-5-alcohol extraction, so that the product is more durable.

Example 1

A bacteriostatic mite-killing spray for children comprises the following raw materials in parts by weight: 91.13 parts of component A; 7.75 parts of a component B; 0.6 part of a component C; the raw material of the component A comprises 91.1 parts of water; 0.03 part of a stabilizer; the raw material of the component B comprises 6 parts of humectant; 0.15 part of a freshener; 0.2 part of preservative; 1.4 parts of surfactant, and the raw materials of the component C comprise 0.6 part of bacteriostatic acarid-removing agent. The surfactant comprises 0.42 part of water; 0.35 part of propylene glycol; nonylphenol polyether-140.35 parts; 0.28 part of PEG-50 castor oil. In the bacteriostatic mite-killing agent, 0.54 part of phenoxyethanol is added; and 0.06 part of ethylhexyl glycerol.

As shown in fig. 1, which is a schematic flow chart of a method for preparing the bacteriostatic mite-killing spray for children in embodiment 1, the method for preparing the bacteriostatic mite-killing spray for children in embodiment 1 includes the following steps:

s1, adding the component A into a container, and fully stirring until the component A is completely dissolved;

s2, preheating the component B, fully stirring until the component B is completely dissolved, and then adding the component B into the component A;

s3, adding the component C, fully stirring and uniformly mixing;

s4, detecting the semi-finished product, and filtering and discharging after the semi-finished product is qualified;

s5, storing;

and S6, filling, packaging and warehousing.

The preparation method of the children type bacteriostatic mite-killing spray in the embodiment 1 is simple in process and easy to prepare.

Example 2

A bacteriostatic mite-killing spray for children comprises the following raw materials in parts by weight: 93.15 parts of component A; 6.35 parts of a component B; 0.5 part of a component C; the raw material of the component A comprises 93.1 parts of water; 0.05 part of a stabilizer; the raw material of the component B comprises 5 parts of humectant; 0.1 part of a freshener; 0.15 part of preservative; 1.1 parts of surfactant, and the raw materials of the component C comprise 0.5 part of bacteriostatic acarid-removing agent. The surfactant comprises 0.33 part of water; 0.275 part of propylene glycol; nonylphenol polyether-140.275 parts; 0.22 part of PEG-50 castor oil. In the bacteriostatic mite-killing agent, 0.45 part of phenoxyethanol is added; and 0.05 part of ethylhexyl glycerol.

A preparation method of the bacteriostatic mite-killing spray for children is used for preparing the bacteriostatic mite-killing spray for children in example 2, and comprises the following steps:

s1, adding the component A into a container, and fully stirring until the component A is completely dissolved;

s2, preheating the component B, fully stirring until the component B is completely dissolved, and then adding the component B into the component A;

s3, adding the component C, fully stirring and uniformly mixing;

s4, detecting the semi-finished product, and filtering and discharging after the semi-finished product is qualified;

s5, storing;

and S6, filling, packaging and warehousing.

Example 3

A bacteriostatic mite-killing spray for children comprises the following raw materials in parts by weight: 95.17 parts of a component A; 4.95 parts of a component B; 0.4 part of component C; the raw material of the component A comprises 95.1 parts of water; 0.07 part of a stabilizer; the raw material of the component B comprises 4 parts of humectant; 0.05 part of a freshener; 0.1 part of preservative; 0.8 part of surfactant, and 0.4 part of bacteriostatic mite-killing agent as the raw material of the component C. The surfactant comprises 0.24 part of water; 0.2 part of propylene glycol; 140.2 parts of nonyl phenol polyether; 0.16 part of PEG-50 castor oil. In the bacteriostatic mite-killing agent, 0.36 part of phenoxyethanol is added; and 0.04 part of ethylhexyl glycerol.

A preparation method of the bacteriostatic mite-killing spray for children is used for preparing the bacteriostatic mite-killing spray for children in example 3, and comprises the following steps:

s1, adding the component A into a container, and fully stirring until the component A is completely dissolved;

s2, preheating the component B, fully stirring until the component B is completely dissolved, and then adding the component B into the component A;

s3, adding the component C, fully stirring and uniformly mixing;

s4, detecting the semi-finished product, and filtering and discharging after the semi-finished product is qualified;

s5, storing;

and S6, filling, packaging and warehousing.

Example 4

On the basis of example 1, 0.29 part by weight of methyl 3-phenylpropionate was added, and the other conditions were kept the same as in example 1. The preparation method was the same as example 1, and methyl 3-phenylpropionate was added together with the C component at step S3.

Example 5

On the basis of example 2, 0.16 part by weight of methyl 3-phenylpropionate was added, and the other conditions were kept the same as in example 2. The preparation method was the same as in example 2, and methyl 3-phenylpropionate was added together with the C component at step S3.

Example 6

On the basis of example 3, 0.1 part by weight of ethyl 3-phenylpropionate was added, and the other conditions were kept the same as in example 3. The preparation method was the same as example 3, and ethyl 3-phenylpropionate was added together with the C component at step S3.

Comparative example 1

Phenoxyethanol starting material was removed from the C component of example 2, and the other conditions remained the same as in example 2.

Comparative example 2

The raw material ethylhexyl glycerin in the C component of example 2 was removed, and the other conditions were kept the same as in example 2.

Mite control Performance test

The method comprises the steps of taking dust mites as test objects, selecting 5 culture dishes containing 100 mites, respectively placing the culture dishes in a closed cylinder test device made of glass, and respectively filling the children type bacteriostatic mite-killing spray prepared in the examples 1-6 and the comparative examples 1-2 into a spraying device. And (3) pressing and spraying each bacteriostatic mite-killing spray for children into the closed cylinder for 10 times, and observing the number of knocked-down mites by using a microscope after 10 minutes. The knock down rate was calculated for 10 minutes and observed for 24 hour mortality as shown in table 1:

TABLE 1 statistical table of mite-killing test results

Testing	10 minute knockdown (%)	24-hour mortality (%)
			Example 1	92	96
Example 2	90	93
			Example 3	88	89
Example 4	94	97
			Example 5	93	96
Example 6	91	93
			Comparative example 1	80	85
Comparative example 2	79	83

As can be seen from Table 1, examples 1-3 all have better mite removing effect, the mite removing effect is further improved after the D component is added in examples 4-6, phenoxyethanol is not added in comparative example 1, and ethylhexyl glycerin is not added in comparative example 2, and the effect is poorer than that of example 2.

Test of bacteriostatic Property

The bactericidal effect was examined with reference to QB/T2738-.

TABLE 2 statistical table of bacteriostatic test results

As can be seen from Table 2, the bacteriostatic mite-killing spray for children of examples 1-3 has excellent bactericidal effect, and the bactericidal effect is further improved after the D component is added in examples 4-6. The sterilization effect of the composition is poorer than that of the embodiment 2 in the comparative example 1 and the comparative example 2, which show that the compound of the phenoxyethanol and the ethylhexyl glycerin has better sterilization effect.

It should be understood that the above-mentioned embodiments of the present invention are only examples for clearly illustrating the technical solutions of the present invention, and are not intended to limit the specific embodiments of the present invention. Any modification, equivalent replacement, and improvement made within the spirit and principle of the present invention claims should be included in the protection scope of the present invention claims.

Claims (9)

1. The bacteriostatic mite-killing spray for children is characterized by comprising the following raw materials in parts by weight: 90.15-96.15 parts of the component A; 4.35-8.35 parts of a component B; 0.3-0.7 part of a component C; the raw materials of the component A comprise water and a stabilizer; the raw materials of the component B comprise a humectant, a freshener, a preservative and a surfactant; the raw material of the component C comprises a bacteriostatic mite-killing agent which is a mixture of phenoxyethanol and ethylhexyl glycerin.

2. The bacteriostatic mite-killing spray for children according to claim 1, wherein the component A comprises the following raw materials in parts by weight: 91.1-95.1 parts of water; 0.03-0.07 part of stabilizer.

3. The bacteriostatic mite-killing spray for children according to claim 1, wherein the component B comprises the following raw materials in parts by weight: 4-6 parts of a humectant; 0.05-0.15 part of a freshener; 0.1-0.2 part of preservative; 0.8-1.4 parts of surfactant.

4. The bacteriostatic mite-killing spray for children according to claim 1, wherein the component C comprises the following raw materials in parts by weight: 0.4-0.6 part of bacteriostatic acarid-removing agent.

5. The bacteriostatic mite-killing spray for children according to claim 1, wherein the weight part ratio of the phenoxyethanol to the ethylhexyl glycerin is 9: 1.

6. the bacteriostatic mite-killing spray for children according to claim 1, wherein the stabilizer is EDTA-disodium and/or the humectant is methyl propylene glycol.

7. A bacteriostatic mite-killing spray for children according to claim 1, wherein the freshener is menthol and/or the preservative is o-cymene-5-ol.

8. The bacteriostatic mite-killing spray for children according to claim 1, wherein the surfactant comprises water, propylene glycol, nonylphenol polyether-14 and PEG-50 castor oil, and the ratio of the water: propylene glycol: polyether-14 phenol: the weight portion ratio of the PEG-50 castor oil is 6: 5: 5: 4.

9. the preparation method of the bacteriostatic mite-killing spray for children according to any one of claims 1 to 8, which is characterized by comprising the following steps:

s1, adding the component A into a container, and fully stirring until the component A is completely dissolved;

s2, preheating the component B, fully stirring until the component B is completely dissolved, and then adding the component B into the component A;

s3, adding the component C, fully stirring and uniformly mixing;

s4, detecting the semi-finished product, and filtering and discharging after the semi-finished product is qualified;

s5, storing;

and S6, filling, packaging and warehousing.

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