CN112739419A - 用于阿尔茨海默症的基因治疗 - Google Patents

用于阿尔茨海默症的基因治疗 Download PDF

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Publication number
CN112739419A
CN112739419A CN201980049127.3A CN201980049127A CN112739419A CN 112739419 A CN112739419 A CN 112739419A CN 201980049127 A CN201980049127 A CN 201980049127A CN 112739419 A CN112739419 A CN 112739419A
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vector
disease
aav2
polynucleotide
promoter
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CN201980049127.3A
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沈洁
R·J·凯莱赫三世
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Brigham and Womens Hospital Inc
General Hospital Corp
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Brigham and Womens Hospital Inc
General Hospital Corp
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    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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    • C12Y304/23045—Memapsin 1 (3.4.23.45), i.e. beta-secretase 2 or BACE2
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    • C12Y304/23—Aspartic endopeptidases (3.4.23)
    • C12Y304/23046—Memapsin 2 (3.4.23.46), i.e. beta-secretase 1 or BACE
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
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CN201980049127.3A 2018-05-22 2019-05-22 用于阿尔茨海默症的基因治疗 Pending CN112739419A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862675003P 2018-05-22 2018-05-22
US62/675,003 2018-05-22
PCT/US2019/033616 WO2019226832A1 (en) 2018-05-22 2019-05-22 Gene therapy for alzheimer's disease

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Publication Number Publication Date
CN112739419A true CN112739419A (zh) 2021-04-30

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CN201980049127.3A Pending CN112739419A (zh) 2018-05-22 2019-05-22 用于阿尔茨海默症的基因治疗

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US (1) US12497608B2 (https=)
EP (1) EP3796980A4 (https=)
JP (1) JP7587423B2 (https=)
CN (1) CN112739419A (https=)
AU (1) AU2019272848A1 (https=)
CA (1) CA3100946A1 (https=)
IL (1) IL278813A (https=)
WO (1) WO2019226832A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115125244A (zh) * 2022-05-14 2022-09-30 吉林大学 构建阿尔兹海默症的兔模型方法
CN116024270A (zh) * 2021-12-27 2023-04-28 中国科学院昆明动物研究所 一种app/psen1双转基因阿尔茨海默病树鼩模型的建立方法

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EP3796980A4 (en) 2018-05-22 2022-03-23 The Brigham & Women's Hospital, Inc. NEW THERAPY FOR ALZHEIMER'S DISEASE
WO2020242892A1 (en) 2019-05-24 2020-12-03 The Brigham And Women's Hospital, Inc. Gene therapy for alzheimer's disease
IL293285A (en) * 2019-11-29 2022-07-01 Paros Bio Inc Gene therapy for neurodegenerative disorders
WO2022261413A1 (en) * 2021-06-10 2022-12-15 The Brigham And Women’S Hospital, Inc. Cell-based assay for identification of activators of gamma-secretase
EP4399311A4 (en) * 2021-09-10 2025-11-26 Alnylam Pharmaceuticals Inc APP ARNI COMPOSITIONS AND THEIR METHODS OF USE FOR TREATMENT OR PREVENTION OF DISEASES CHARACTERIZED BY ENLARGED ENDOSOMES

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116024270A (zh) * 2021-12-27 2023-04-28 中国科学院昆明动物研究所 一种app/psen1双转基因阿尔茨海默病树鼩模型的建立方法
CN116024270B (zh) * 2021-12-27 2025-07-22 中国科学院昆明动物研究所 一种app/psen1双转基因阿尔茨海默病树鼩模型的建立方法
CN115125244A (zh) * 2022-05-14 2022-09-30 吉林大学 构建阿尔兹海默症的兔模型方法

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US12497608B2 (en) 2025-12-16
JP2021525245A (ja) 2021-09-24
IL278813A (en) 2021-01-31
AU2019272848A1 (en) 2020-12-03
CA3100946A1 (en) 2019-11-28
JP7587423B2 (ja) 2024-11-20
EP3796980A4 (en) 2022-03-23
US20210108186A1 (en) 2021-04-15
EP3796980A1 (en) 2021-03-31

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