CN112725268A - 一种促进脂肪干细胞成骨分化的组合物及其应用 - Google Patents
一种促进脂肪干细胞成骨分化的组合物及其应用 Download PDFInfo
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- CN112725268A CN112725268A CN202110114696.0A CN202110114696A CN112725268A CN 112725268 A CN112725268 A CN 112725268A CN 202110114696 A CN202110114696 A CN 202110114696A CN 112725268 A CN112725268 A CN 112725268A
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
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Abstract
Description
细胞株 | 效价 |
GYH-3 | 4.5×10<sup>7</sup> |
GYH-8 | 1.7×10<sup>8</sup> |
GYH-17 | 3.6×10<sup>8</sup> |
表面抗原 | CD29 | CD34 | CD44 | CD45 | CD105 | HLA-DR |
流式表达 | + | - | + | - | + | - |
Claims (5)
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CN202110114696.0A CN112725268B (zh) | 2021-01-28 | 2021-01-28 | 一种促进脂肪干细胞成骨分化的组合物及其应用 |
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CN202110114696.0A CN112725268B (zh) | 2021-01-28 | 2021-01-28 | 一种促进脂肪干细胞成骨分化的组合物及其应用 |
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CN112725268B CN112725268B (zh) | 2021-10-01 |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114957466A (zh) * | 2022-04-26 | 2022-08-30 | 广州泰术生物科技有限公司 | 一种干细胞在制备人工皮肤中的用途 |
CN115894681A (zh) * | 2022-12-15 | 2023-04-04 | 广州佳敬科技有限公司 | 一种用于间充质干细胞分化的制剂 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106687602A (zh) * | 2014-06-13 | 2017-05-17 | 维也纳自然资源与生命科学大学 | 用于诊断和治疗骨折和骨病的组合物及方法 |
WO2018035307A1 (en) * | 2016-08-18 | 2018-02-22 | Mayo Foundation For Medical Education And Research | Materials and methods for enhancing bone cell differentiation |
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2021
- 2021-01-28 CN CN202110114696.0A patent/CN112725268B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106687602A (zh) * | 2014-06-13 | 2017-05-17 | 维也纳自然资源与生命科学大学 | 用于诊断和治疗骨折和骨病的组合物及方法 |
WO2018035307A1 (en) * | 2016-08-18 | 2018-02-22 | Mayo Foundation For Medical Education And Research | Materials and methods for enhancing bone cell differentiation |
Non-Patent Citations (5)
Title |
---|
HEATHER FAIRFIELD等: "Connecting Bone and Fat: The Potential Role for Sclerostin", 《CURR MOL BIOL REP》 * |
LI YOU等: "SOST Gene Inhibits Osteogenesis from Adipose-Derived Mesenchymal Stem Cells by Inducing Th17 Cell Differentiation", 《CELLULAR PHYSIOLOGY AND BIOCHEMISTRY》 * |
MUHAMMAD U. JAWAD等: "Effects of Sclerostin Antibody on Healing of a Non-CriticalSize Femoral Bone Defect", 《JOURNAL OF ORTHOPAEDIC RESEARCH》 * |
杨九杰等: "脂肪间充质干细胞成骨分化条件培养基联合骨形态发生蛋白2治疗去卵巢大鼠骨质疏松症", 《中国组织工程研究》 * |
罗世洪: "Wnt信号通路在骨质疏松小鼠脂肪干细胞成骨分化中的作用", 《中国优秀硕士学位论文全文数据库 医药卫生科技辑》 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114957466A (zh) * | 2022-04-26 | 2022-08-30 | 广州泰术生物科技有限公司 | 一种干细胞在制备人工皮肤中的用途 |
CN114957466B (zh) * | 2022-04-26 | 2023-04-11 | 上海东方星际干细胞科技有限公司 | 一种干细胞在制备人工皮肤中的用途 |
CN115894681A (zh) * | 2022-12-15 | 2023-04-04 | 广州佳敬科技有限公司 | 一种用于间充质干细胞分化的制剂 |
CN115894681B (zh) * | 2022-12-15 | 2023-09-12 | 中科中銮生物科技(广东)有限公司 | 一种用于间充质干细胞分化的制剂 |
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