CN112717098A - Ant oil liniment and preparation method thereof - Google Patents

Ant oil liniment and preparation method thereof Download PDF

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Publication number
CN112717098A
CN112717098A CN202110078047.XA CN202110078047A CN112717098A CN 112717098 A CN112717098 A CN 112717098A CN 202110078047 A CN202110078047 A CN 202110078047A CN 112717098 A CN112717098 A CN 112717098A
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parts
oil
liniment
turpentine
ant
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谢存焱
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/64—Insects, e.g. bees, wasps or fleas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A61K31/125—Camphor; Nuclear substituted derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/58—Reptiles
    • A61K35/583—Snakes; Lizards, e.g. chameleons
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286—Carthamus (distaff thistle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/56—Loganiaceae (Logania family), e.g. trumpetflower or pinkroot
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction

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Abstract

The invention discloses an ant oil liniment and a preparation method thereof, relating to the technical field of external drugs, wherein the liniment comprises the following raw materials in parts by weight: 35-40 parts of polyrhachis vicina Roger, 7-10 parts of nux vomica, 10-15 parts of Ligusticum wallichii, 8-10 parts of safflower, 10-15 parts of turmeric, 12-18 parts of radix angelicae pubescentis, 12-18 parts of turpentine, 10-15 parts of snake oil, 8-12 parts of cinnamon oil, 9-13 parts of wintergreen oil, 10-15 parts of peppermint oil, 8-12 parts of clove oil, 9-12 parts of camphor and 0-0.5 part of natural pigment. The liniment is prepared from ant as a main raw material, and Chinese herbal medicines of nux vomica, ligusticum wallichii, safflower, turmeric and radix angelicae pubescentis, snake oil, turpentine, cassia oil, wintergreen oil, peppermint oil, clove oil and camphor, and has good treatment effect on rheumatic arthritis, rheumatoid arthritis and scapulohumeral periarthritis, and the liniment is acceptable by various patients.

Description

Ant oil liniment and preparation method thereof
Technical Field
The invention relates to the technical field of external drugs, in particular to ant oil liniment and a preparation method thereof.
Background
Ants, an insect that has been in the same generation as dinosaurs, have a history of hundreds of millions of years to date. How many animals in the world die in harsh environments or are not at all. Ants can live down by the tenacious vitality of themselves; the breeding speed is increased every 28 days. Scientific research finds that ants rarely suffer from diseases, and the reasons are that the ants contain extremely strong antibiotics, more than 50 trace elements and 28 amino acids in vivo; the ant has antirheumatic, antiinflammatory, antibacterial, hepatoprotective, and spasmolytic effects. In recent years, the effective components of ants are respectively prepared into tablets, pills and wine soaking drinks for clinical treatment, and the ants have health care and treatment functions as a medicament and are also reported frequently. The ants are used for treating diseases in an oral form, and certain side effects can be generated to certain people inevitably, such as a wine soaking mode, and the ant is not suitable for people who drink wine; some patients taking tablets and pills orally have adverse phenomena.
Disclosure of Invention
Therefore, the invention provides an ant oil liniment and a preparation method thereof, and aims to solve the problems of side effects and narrow application range of the existing ant preparations when the existing ant preparations are directly taken.
In order to achieve the above purpose, the invention provides the following technical scheme:
according to a first aspect of the invention, an ant oil liniment comprises the following raw materials in parts by weight: 35-40 parts of polyrhachis vicina Roger, 7-10 parts of nux vomica, 10-15 parts of Ligusticum wallichii, 8-10 parts of safflower, 10-15 parts of turmeric, 12-18 parts of radix angelicae pubescentis, 12-18 parts of turpentine, 10-15 parts of snake oil, 8-12 parts of cinnamon oil, 9-13 parts of wintergreen oil, 10-15 parts of peppermint oil, 8-12 parts of clove oil, 9-12 parts of camphor and 0-0.5 part of natural pigment.
Further, the liniment comprises the following raw materials in parts by weight: 36-38 parts of polyrhachis vicina Roger, 8-9 parts of nux vomica, 12-14 parts of Ligusticum wallichii, 8.5-9.5 parts of safflower, 12-14 parts of turmeric, 14-16 parts of radix angelicae pubescentis, 14-16 parts of turpentine, 12-14 parts of snake oil, 9-11 parts of cassia oil, 10-12 parts of wintergreen oil, 12-14 parts of mint oil, 9-11 parts of clove oil, 9.5-11 parts of camphor and 0-0.5 part of natural pigment.
The turpentine oil in the raw materials of the ant oil liniment has the analgesic effect, and is a better liniment in the pharmaceutical industry. The snake oil consists of a plurality of fatty acids, wherein linoleic acid and linolenic acid are the fatty acids necessary for human bodies, and the snake oil not only can inhibit the growth of bacteria, but also has curative effects on acute dermatitis and eczema and can also eliminate muscle fatigue; peppermint oil is suitable for dissipating wind heat; the cassia bark oil has the effects of tonifying fire, supporting yang, dispelling cold, relieving pain, activating blood and dredging the channel; semen Strychni has antibacterial effect and can promote bone marrow hematopoiesis; the clove kidney strengthens yang; the wintergreen oil, the turmeric, the camphor, the Szechuan lovage rhizome and the safflower all have the functions of dissipating blood stasis, activating blood circulation, dispelling wind and relieving pain; the natural pigment is used for adjusting the color of the finished oil product, so that the color of each batch of ant oil is similar to that of each batch of ant oil as much as possible.
The liniment of the invention takes polyrhachis vicina Roger as a main body and is prepared by adopting the compatibility of pure natural Chinese herbal medicines. Ant is neutral in flavor and enters liver and kidney meridians. Has effects in enhancing immunity, caring skin, relieving inflammation, relieving asthma, tranquilizing mind, and relieving spasm, and can be rapidly permeated into skin tissue by matching with semen Strychni, Curcuma rhizome, Carthami flos, rhizoma Ligustici Chuanxiong, radix Angelicae Pubescentis, adeps Serpentis, oleum Terebinthinae, oleum Cinnamomi, wintergreen oil, herba Menthae Dementholatum, oleum Caryophylli, and Camphora. Promoting blood circulation, relieving muscle fatigue, relaxing muscles and tendons, activating collateral flow, resisting rheumatism, and inhibiting bacteria.
According to a second aspect of the invention, a process for the preparation of the liniment described above, comprising the steps of:
weighing cleaned polyrhachis vicina Roger, semen Strychni, rhizoma Ligustici Chuanxiong, Carthami flos, Curcuma rhizome, and radix Angelicae Pubescentis, placing into a distillation extraction tank, adding purified water 2-3 times of the weight of the materials, heating to above 60 deg.C, distilling, extracting, observing no oil through a glass observation hole of the distillation extraction tank, and stopping extraction to obtain oily extract; and then mixing the oily extract with snake oil, turpentine, cassia oil, wintergreen oil, peppermint oil, clove oil and camphor according to a formula ratio to obtain the liniment.
Further, the temperature of the distillation extraction is more than or equal to 60 ℃ and less than 100 ℃.
Further, the method further comprises: concentrating the oily extract to obtain a paste extract, and mixing with snake oil, turpentine, cassia oil, wintergreen oil, peppermint oil, clove oil and camphor according to a formula ratio to obtain the liniment.
Further, the extraction time is 5-6 h.
The invention has the following advantages:
the ant oil liniment is prepared by taking ant as a main raw material and assisting with various Chinese herbal medicines of nux vomica, ligusticum wallichii, safflower, turmeric, radix angelicae pubescentis, snake oil, turpentine, cassia oil, wintergreen oil, peppermint oil, clove oil and camphor, is acceptable by various patients, is applied by the patients, achieves the aim of treatment and health care by a mode of skin absorption of the human body, and has good treatment effect on rheumatic arthritis, rheumatoid arthritis and scapulohumeral periarthritis.
The preparation method of the ant oil liniment extracts the effective components in the polyrhachis vicina Roger and the Chinese herbal medicine components by adopting a distillation extraction method, improves the extraction efficiency of the effective components in the ants and the Chinese herbal medicine components, enables the effective substances in the raw materials to better act on a human body, and improves the use effect of the liniment.
Detailed Description
The present invention is described in terms of particular embodiments, other advantages and features of the invention will become apparent to those skilled in the art from the following disclosure, and it is to be understood that the described embodiments are merely exemplary of the invention and that it is not intended to limit the invention to the particular embodiments disclosed. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
An ant oil liniment comprises the following raw materials: 70 g of polyrhachis vicina Roger, 14 g of nux vomica, 20 g of Ligusticum wallichii, 16 g of safflower, 20 g of turmeric, 24 g of radix angelicae pubescentis, 24 g of turpentine, 20 g of snake oil, 16 g of cinnamon oil, 18 g of wintergreen oil, 20 g of peppermint oil, 16 g of clove oil and 18 g of camphor.
The preparation method of the liniment comprises the following steps:
weighing and selecting clean polyrhachis vicina Roger, semen Strychni, rhizoma Ligustici Chuanxiong, Carthami flos, Curcuma rhizome, and radix Angelicae Pubescentis, placing into a distillation extraction tank, adding 2 times of purified water, heating to 60 deg.C to begin to produce oil, controlling temperature at 60-95 deg.C, distilling and extracting, observing no oil through a glass observation hole of the distillation extraction tank, stopping extraction, and extracting for 5-6 hr to obtain oily extract; and then mixing the oily extract with snake oil, turpentine, cassia oil, wintergreen oil, peppermint oil, clove oil and camphor according to a formula ratio to obtain the liniment.
Example 2
An ant oil liniment comprises the following raw materials: 360 g of polyrhachis vicina Roger, 80 g of nux vomica, 120 g of Ligusticum wallichii, 85 g of safflower, 120 g of turmeric, 140 g of radix angelicae pubescentis, 140 g of turpentine, 120 g of snake oil, 90 g of cassia oil, 100 g of wintergreen oil, 120 g of peppermint oil, 90 g of clove oil and 95 g of camphor.
The preparation method of the liniment comprises the following steps:
weighing and selecting clean polyrhachis vicina Roger, semen Strychni, rhizoma Ligustici Chuanxiong, Carthami flos, Curcuma rhizome, and radix Angelicae Pubescentis, placing into a distillation extraction tank, adding 2 times of purified water, heating to 60 deg.C to begin to produce oil, controlling temperature at 60-95 deg.C, distilling and extracting, observing no oil through a glass observation hole of the distillation extraction tank, stopping extraction, and extracting for 5-6 hr to obtain oily extract; and concentrating the oily extract to obtain a paste extract, and mixing with snake oil, turpentine, cassia oil, wintergreen oil, peppermint oil, clove oil and camphor according to a formula ratio to obtain the liniment.
Example 3
An ant oil liniment comprises the following raw materials: 185 g of polyrhachis vicina Roger, 42.5 g of nux vomica, 100 g of Ligusticum wallichii, 80 g of safflower, 100 g of turmeric, 120 g of radix angelicae pubescentis, 120 g of turpentine, 100 g of snake oil, 80 g of cassia oil, 90 g of wintergreen oil, 100 g of peppermint oil, 80 g of clove oil and 90 g of camphor.
The preparation method of the liniment is the same as that of example 1.
Example 4
An ant oil liniment comprises the following raw materials: 152 g of polyrhachis vicina Roger, 36 g of nux vomica, 56 g of ligusticum wallichii, 38 g of safflower, 56 g of turmeric, 64 g of radix angelicae pubescentis, 64 g of turpentine, 56 g of snake oil, 44 g of cassia oil, 48 g of wintergreen oil, 56 g of peppermint oil, 44 g of clove oil and 44 g of camphor.
The preparation method of the liniment is the same as that of example 1.
Example 5
An ant oil liniment comprises the following raw materials: 120 g of polyrhachis vicina Roger, 100 g of nux vomica, 150 g of Ligusticum wallichii, 100 g of safflower, 150 g of turmeric, 180 g of radix angelicae pubescentis, 180 g of turpentine, 150 g of snake oil, 120 g of cinnamon oil, 130 g of wintergreen oil, 150 g of peppermint oil, 120 g of clove oil, 120 g of camphor and 1.5 g of natural pigment.
The preparation method of the liniment is the same as that of example 1.
Experimental example 1
1. Multiple skin irritation test
1.1, materials and animals
The test substance: the invention relates to an ant oil liniment.
Experimental animals and breeding environment: 3 ordinary Japanese big ear rabbits with the weight of 2300-: SCXK (gan) 2014-. Animal house certification number SCXK (gan) 2012-. Feeding in single cage at room temperature of 21.5-26.3 deg.C and humidity of 51-60% RH.
1.2 methods
The detection basis is as follows: disinfection Specification (2002 edition) 2.3.3.3.3
The experimental method comprises the following steps: shearing off hair on two sides of the spine of the back of the animal before 24 hours of the experiment, wherein the area of each block is about 3cm multiplied by 3cm, coating 0.5mL of a tested object on a hair removing area on one side in the experiment, a blank control on the other side, and a coating area is 2.5cm multiplied by 2.5cm, and cleaning with water to remove residues 4 hours after coating. The product is applied once a day for 14 days, and the result is observed 24h after each application.
The observation results were scored according to the skin irritation response scoring criteria of tables 2-11 of "skin irritation test" 2.3.3 in the "Disinfection Specification" (2002 edition), the average score per animal per day was calculated, and the skin irritation intensity was determined according to tables 2-12.
1.3 test results
The observation points of the experiment show that no experimental animal generates erythema and edema, the integral mean value of the animal irritation reaction after the experiment is finished is 0, and the result of the repeated skin irritation test of the ant oil liniment to the Japanese big-ear rabbit is shown in table 1.
Table 1 result table of repeated skin irritation test of the ant oil liniment of the present invention to japanese big ear rabbit
Figure BDA0002907994940000051
Figure BDA0002907994940000061
2. Determination of pH value
2.1 materials
Sample preparation: the invention relates to an ant oil liniment
A pH meter: sevenmulti type precision pH meter
pH buffer: mixed phosphate grade AR (pH6.86) potassium hydrogenphthalate grade AR (pH5.90) borax grade AR (pH9.18)
2.2 methods
The detection basis is as follows: ministry of health, Disinfection Specification 2002 edition 2.2.1.4
And (3) testing the environment: temperature: 20.7 ℃ relative humidity: 33 percent
Sample solubility: stock solution
2.3, results
Table 2 pH value measurement results of ant oil liniment of the present invention
Figure BDA0002907994940000071
The results in table 2 show that the pH of the ant oil liniment of the present invention is 8.4.
3. Inhibition of the Ring test
3.1 apparatus
Test bacteria: staphylococcus aureus (ATCC6538) generation 6 (supplied by military medical academy of sciences), Escherichia coli (8099) generation 6 (supplied by military medical academy of sciences)
Candida albicans (ATCC10231) generation 6 (supplied by military medical academy of sciences)
Test samples: the invention relates to an ant oil liniment
Micropipettor, vernier caliper
3.2 methods
The inspection basis is as follows: disinfection technical Specification 2002 edition 2.1.8.2 of Ministry of public health
3.3 results
TABLE 3 bacteriostatic effect of ant oil liniment of the present invention on experimental bacteria
Figure BDA0002907994940000072
The result of 3 shows that the ant oil liniment has the average inhibiting ring diameters of 10.0(9.5-10.5) mm, 10.0(9.5-10.5) mm and 8.5(8.0-9.0) mm for staphylococcus aureus, escherichia coli and candida albicans respectively, and has the bacteriostatic effect on the staphylococcus aureus, the escherichia coli and the candida albicans.
4. Microbial contamination detection
4.1, test sample: the invention relates to an ant oil liniment
4.2 methods
The detection basis is as follows: GB15979-2002 appendix B
Detection conditions are as follows: ambient temperature: 18.2-18.7 ℃ and 40-46 percent of relative humidity
4.3, results
Table 4 results of microbial contamination test of ant oil liniment in accordance with the present invention
Detecting the index Standard value Measured value
Total bacterial colony count (cfu/mL) ≤200 ≤10
Coliform group bacteria Cannot be detected Not detected out
Staphylococcus aureus Cannot be detected Not detected out
Pseudomonas aeruginosa Cannot be detected Not detected out
Hemolytic streptococcus Cannot be detected Not detected out
Total fungal colony count (cfu/mL) ≤100 94
From the results of 4, the microbial contamination detection result of the ant oil liniment conforms to the regulation of GB 15979-2002.
5. Stability test
5.1 apparatus
Test bacteria: staphylococcus aureus (ATCC6538) generation 6 (supplied by military medical academy of sciences)
Test samples: the invention relates to an ant oil liniment
Micropipettor, vernier caliper
5.2 methods
The detection basis is as follows: ministry of health, Disinfection Specification 2002 edition 2.2.3, 2.1.8.2
Storage conditions are as follows: placing in a 37 deg.C incubator for 3 months (without color change, precipitate and suspended matter)
5.3, results
Table 5 stability test of ant oil liniment to test bacteria
Figure BDA0002907994940000091
5, the result shows that the ant oil liniment has bacteriostatic action on staphylococcus aureus after being placed in a constant temperature box at 37 ℃ for 3 months, and the effective period lasts two years.
Experimental example 2
180 cases of the ant oil liniment of the invention are used by patients with rheumatic arthritis, rheumatoid arthritis and scapulohumeral periarthritis, 175 cases of the liniment achieve the effect of relieving pain within 5-15 minutes, and the effective rate reaches 97.2 percent.
Although the invention has been described in detail above with reference to a general description and specific examples, it will be apparent to one skilled in the art that modifications or improvements may be made thereto based on the invention. Accordingly, such modifications and improvements are intended to be within the scope of the invention as claimed.

Claims (6)

1. The ant oil liniment is characterized by comprising the following raw materials in parts by weight: 35-40 parts of polyrhachis vicina Roger, 7-10 parts of nux vomica, 10-15 parts of Ligusticum wallichii, 8-10 parts of safflower, 10-15 parts of turmeric, 12-18 parts of radix angelicae pubescentis, 12-18 parts of turpentine, 10-15 parts of snake oil, 8-12 parts of cinnamon oil, 9-13 parts of wintergreen oil, 10-15 parts of peppermint oil, 8-12 parts of clove oil, 9-12 parts of camphor and 0-0.5 part of natural pigment.
2. The liniment according to claim 1, wherein the liniment comprises the following raw materials in parts by weight: 36-38 parts of polyrhachis vicina Roger, 8-9 parts of nux vomica, 12-14 parts of Ligusticum wallichii, 8.5-9.5 parts of safflower, 12-14 parts of turmeric, 14-16 parts of radix angelicae pubescentis, 14-16 parts of turpentine, 12-14 parts of snake oil, 9-11 parts of cassia oil, 10-12 parts of wintergreen oil, 12-14 parts of mint oil, 9-11 parts of clove oil, 9.5-11 parts of camphor and 0-0.5 part of natural pigment.
3. The process for the preparation of a liniment according to any one of claims 1 to 2, comprising the following steps:
weighing cleaned polyrhachis vicina Roger, semen Strychni, rhizoma Ligustici Chuanxiong, Carthami flos, Curcuma rhizome, and radix Angelicae Pubescentis, placing into a distillation extraction tank, adding purified water 2-3 times of the weight of the materials, heating to above 60 deg.C, distilling, extracting, observing no oil through a glass observation hole of the distillation extraction tank, and stopping extraction to obtain oily extract; and then mixing the oily extract with snake oil, turpentine, cassia oil, wintergreen oil, peppermint oil, clove oil and camphor according to a formula ratio to obtain the liniment.
4. The process for the preparation of a liniment according to claim 3, wherein the temperature of the distillative extraction is greater than or equal to 60 ℃ and less than 100 ℃.
5. The method for preparing the liniment of claim 3, further comprising: concentrating the oily extract to obtain a paste extract, and mixing with snake oil, turpentine, cassia oil, wintergreen oil, peppermint oil, clove oil and camphor according to a formula ratio to obtain the liniment.
6. The process for the preparation of the liniment according to claim 3, wherein the extraction time is between 5 and 6 h.
CN202110078047.XA 2021-01-20 2021-01-20 Ant oil liniment and preparation method thereof Pending CN112717098A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1781543A (en) * 2004-12-03 2006-06-07 谢存焱 Ant oil liniment and its preparing method
CN103301407A (en) * 2013-06-26 2013-09-18 陈黎光 Ant wind dispelling essential oil liniment and preparation method thereof
CN109793882A (en) * 2019-03-25 2019-05-24 南京小蚁健康科学研究院有限公司 A kind of Chinese medicine composition and its preparation method and application containing ant

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1781543A (en) * 2004-12-03 2006-06-07 谢存焱 Ant oil liniment and its preparing method
CN103301407A (en) * 2013-06-26 2013-09-18 陈黎光 Ant wind dispelling essential oil liniment and preparation method thereof
CN109793882A (en) * 2019-03-25 2019-05-24 南京小蚁健康科学研究院有限公司 A kind of Chinese medicine composition and its preparation method and application containing ant

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