CN112717074A - Medicated wine for preventing and treating alopecia and preparation method thereof - Google Patents
Medicated wine for preventing and treating alopecia and preparation method thereof Download PDFInfo
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Abstract
The invention discloses traditional Chinese medicine medicinal liquor for preventing and treating alopecia, which is prepared from the following raw materials in parts by weight: 10-80 parts of deer blood, 10-80 parts of ginseng, 10-100 parts of silkworm chrysalis, 1-8 parts of nutmeg, 8-64 parts of rhizoma polygonati, 8-64 parts of tangerine peel, 1-8 parts of red yeast rice, 5-40 parts of rock sugar and 500-4000 parts of white spirit; the invention has the beneficial effects that: all the raw materials are edible daily raw materials and raw materials shared by medicine and food, have no toxicity, and have very obvious effects of balancing yin and yang, regulating a nutritional structure, tonifying the kidney, securing essence, enhancing capillary circulation, relieving or preventing nonpathogenic alopecia symptoms, promoting new hair growth and promoting hair follicle metabolism after being continuously taken every day. Embodies the synergy among the chemical components of the traditional Chinese medicine, starts with multiple targets and multiple parts, thereby achieving the effects of prevention and treatment. Compared with single component in the formula, the medicinal liquor has more obvious pharmacological activity.
Description
Technical Field
The invention relates to medicinal liquor for preventing and treating alopecia, belongs to the technical field of medicines or foods, and particularly relates to medicinal liquor for preventing and treating alopecia as well as a preparation method and application thereof.
Background
Alopecia is the phenomenon of hair loss, and is divided into physiological and pathological. Physiological alopecia refers to the normal shedding of hair. Pathologic hair loss refers to abnormal or excessive hair loss. With the increasing social pressure, the accelerating life rhythm, the continuous deterioration of the environment and the poor dietary habits, the base number of unhealthy and sub-healthy people is increased day by day, the incidence rate of alopecia is higher and the incidence population tends to be younger. 60% of men begin to lose hair before the age of 25, the proportion of the loss of hair before the age of 30 accounts for 84%, the loss of hair tends to be low-aged, and the middle-aged and young people become the chief force of the hair loss army.
The reasons for alopecia are many, and western medical theory considers that under normal conditions, abundant blood vessels exist in human hair papillae to provide sufficient nutrition for hair papillae and hair bulb parts, so that hair growth hormone is smoothly synthesized. Various adverse stimuli (influence of hormone level, influence of neurostimulation, etc.) cause vasospasm of supplying hair nutrition, and dysfunction of nutrition-transporting function of hair papilla and hair bulb part. When nutrient synthesis is inhibited in the formation of papilla and bulbus pili, or when ATP having a cell energy function is produced due to some factor, production of ATP is inhibited. ATP, which is a heat source, is not produced, and thus protein synthesis of hair is not performed, hair mother cells lose activity, nutrients in medullary and cortex portions of hair are reduced, keratinization begins, hair follicles begin to atrophy or necrose, hair enters a resting stage in a large amount, and hair falls off in a large amount. Alopecia is manifested by androgenetic alopecia, neurogenic alopecia, endocrine alopecia, nutritional alopecia, physical alopecia, chemical alopecia, infectious alopecia, symptomatic alopecia, congenital alopecia, seasonal alopecia, etc. In order to quickly relieve the trouble caused by alopecia, people often select western medicines with quick curative effect for treatment, but the western medicines have large toxic and side effects, single treatment target and easy relapse of the disease, and mostly treat the symptoms but not the root cause.
The Chinese medicine attracts more and more attention for the purposes of treating diseases and seeking resources and treating diseases and saving basis. According to different understanding on alopecia mechanisms, the Chinese medicine has the common self-help that the main reason is kidney essence deficiency, lung qi deficiency, kidney yin deficiency, spleen dysfunction, liver and kidney deficiency and the like. Therefore, in combination with the above practical problems, there is a need to develop a Chinese medicinal material product which has the effects of nourishing liver and kidney, replenishing essence and blood, nourishing qi and blood, promoting diuresis and excreting dampness as auxiliary materials and can improve the symptoms of different alopecia patients by cutting into the Chinese medicinal material product from multiple angles. At present, functional food prepared by taking traditional Chinese medicines as raw materials can promote human health and regulate specific physiological functions of human bodies, does not produce adverse reactions to human bodies, is more and more popular with people, and has the characteristics of nutrition and sensory enjoyment of common food as well as the characteristics of common food, and can regulate the physiological functions of human bodies, promote the human health, break through sub-health, prevent diseases and the like. In order to solve the practical problems and meet the requirements of people, the medicinal liquor for relieving alopecia takes medicinal and edible traditional Chinese medicinal materials as raw materials.
With the increasing competition pressure of the modern society, the work rhythm of people is faster and faster. In recent years, the trend of people with white hair and alopecia is increasingly obvious. Alopecia has become a more and more important and concerned problem for modern people. The normal hair loss is the hair in the catagen and telogen stages, and the pathological hair loss refers to abnormal or excessive hair loss, which causes the symptoms of alopecia such as seborrheic alopecia, premature alopecia, baldness, alopecia areata, alopecia totalis and the like. Therefore, the medicine which is effective in treating alopecia, has high quality and low price and is convenient to use is found, and has wide prospect.
The sanguis Cervi is blood of Cervus nippon Temminck (Cervus nippon Temminck) of Cervidae. Since ancient times, deer blood is a precious product for treating diseases and building bodies of royal jelly and the sense organ is distinguished, and a compound product taking the deer blood as a main component is called 'Xianjia eating Danfang'. The water content of deer blood is 80% -81%, and the organic matter is 16% -17%, in which it is mainly protein, and the protein is rich in 19 amino acids and several enzymes, in addition, it also contains several lipids, free fatty acids, sterols, phospholipids, hormones, vitamins and polysaccharides, etc. And contains various major elements and beneficial trace elements. In particular, deer blood also contains Y-globulin, cystine, lysine, phosphocreatine kinase related to heart function, and covered enzyme. Promoting the regeneration of hemoglobin in human body and enhancing the hematopoietic function of human body. The deer blood taken by people in a proper amount can improve immunity, promote the regeneration of immune cells in human bodies, invigorate qi and blood, relieve physical weakness and enhance the antiviral capacity of human bodies, is particularly suitable for people with weak constitution and multiple diseases, and can obviously improve physical quality after being taken for a period of time. Improving the oxidation resistance of human body and delaying senility. The deer blood can prevent the generation of lipid peroxide in a human body and clear free radicals in the human body, and people can improve the functions of various organs of the human body and prevent various aging symptoms after taking the deer blood frequently, thereby preventing alopecia.
The Ginseng radix is dried root of Panax ginseng C.A.Mey. Sweet, slightly bitter and even in taste; it enters spleen, lung and heart meridians. Is mainly used for reinforcing primordial qi, restoring pulse, relieving depletion, invigorating spleen, benefiting lung, promoting fluid production, and tranquilizing. Can be used for treating asthenia, collapse, cold limbs, weak pulse, spleen deficiency, anorexia, lung deficiency, cough, asthma, body fluid deficiency, thirst, internal heat, asthenia, palpitation, insomnia, sexual impotence, and cold womb; heart failure, cardiogenic shock. According to research reports, the ginsenoside can promote hair growth and has good hair care effect. Jp etabon et al report that ginsenoside has the effect of enhancing nerve growth factor-reinforced nerve endings). Therefore, it also has hair growth promoting effect. Practice shows that ginseng can directly enter the interior of hair fibers, so that the absorption capacity of the hair to saponin is increased, and the absorption quantity of ginseng is three times higher than that of a protein hydrolysis product. After the hair absorbs the ginsenoside, the multipara group in the saponin and the polypeptide in the hair reddish fiber generate hydrogen bonds which are mutually connected by the action of the hydrogen bonds, so that the tensile strength and elongation of the hair are improved, namely the hair is enhanced in the initial property and is not easy to lose hair. Therefore, ginseng has good hair care effect and is more effective than protein hydrolysate. Research shows that dermal fibroblasts secrete collagen, which can maintain the strength of hair and the fixation of scalp to hair. The morphogenesis and development of hair follicles are the result of the induction of interactions between epidermal and dermal components. The hair matrix and inner and outer root sheaths of hair follicle are derived from skin epithelium, and the hair papilla and dermal sheath of hair follicle are derived from dermis, and can promote proliferation of epidermal keratinocyte and dermal fibroblast, and promote formation and new hair growth of hair follicle. The ethanol percolate of Ginseng radix can promote proliferation of epidermal keratinocyte and dermal fibroblast.
The silkworm pupa is the pupa of the silkworm Bymbyx mori (Linnaeus) which is an insect in the family Bombycidae, is sweet, pungent, salty and slightly warm, and enters spleen, stomach, liver and kidney channels, contains phytoecdysone, and has the effects of promoting synthesis of collagen protein, resisting arrhythmia and fatigue, promoting cell growth and stimulating dermal cell division, thereby achieving the effect of promoting hair regeneration.
The nutmeg is dried kernel of Myristica fragrans Houtt. of Myristica of Myristicaceae. The semen Myristicae contains essential oil as main ingredient, and is effective in decomposing fat and starch foods and stimulating appetite. Can be used for activating heart and promoting blood circulation, and the essential oil of semen Myristicae is beneficial to hair. Has obvious inhibiting effect on 5 alpha R, blocks the conversion of testosterone to dihydrotestosterone, and has the effect of treating androgen-dependent diseases, such as benign prostatic hyperplasia, hirsutism, alopecia, etc.
Rhizoma Polygonati is rhizome of Polygonatum sibiricum (Polygonatum macrocarpium) of Liliaceae, has sweet taste and mild nature, and has effects of invigorating qi, nourishing yin, invigorating spleen, moistening lung, and invigorating kidney. Has the effects of enriching blood, nourishing yin, tonifying kidney, enhancing immunity, resisting fatigue, resisting oxidation, delaying aging and the like, and achieves the effects of blackening hair and preventing alopecia.
Tangerine peel is pungent, bitter and warm in nature. It enters lung and spleen meridians. Exocarpium Citri rubrum is dried outer peel of Rutaceae plant fructus Citri Tangerinae (Citrus reticulata Blanco) and its cultivar. Has effects of dispelling cold, eliminating dampness, activating qi-flowing, and eliminating phlegm. It can be used for treating cough due to wind-cold evil, itching throat, excessive phlegm, and dyspepsia.
Red yeast rice is prepared by fermenting rice such as indica rice, japonica rice and glutinous rice with Monascus purpureus, and is brownish red or purplish red rice grain. The main active components of the red yeast rice are lovastatin and monascus pigment. The monascus pigment is a mixture of multiple pigments, mainly including 2 types of red pigments and yellow pigments, and the pigments are polyketone compounds and simultaneously contain rich B vitamins. The vitamin B group promotes scalp repair and hair collagen and keratin formation, thereby achieving the effect of preventing and treating alopecia.
Before the completion of the invention, no report on the application of a composition consisting of deer blood, ginseng, rhizoma polygonati, silkworm chrysalis, red tangerine peel, nutmeg and red yeast rice in preventing and treating alopecia is found. There is no report on an edible medicated wine prepared from deer blood, ginseng, polygonatum rhizome, silkworm chrysalis, red tangerine peel, nutmeg and red yeast rice.
Disclosure of Invention
The invention aims to provide medicinal liquor for preventing and treating alopecia, which has the function of treating alopecia and a certain hair growth promoting effect by adopting reasonable compatibility and use of seven raw materials. More specifically, the application of the medicinal liquor for preventing and treating the alopecia, which is composed of seven raw materials, in the medicines and health-care products for preventing and treating the alopecia diseases.
The invention is characterized in that edible deer blood, ginseng, sealwort, silkworm chrysalis, red tangerine peel, nutmeg and red yeast rice are firstly combined to prepare medicinal liquor which is firstly used for health-care food or food. The formula of the invention contains protein, amino acid, vitamin, hormone, saponin, polysaccharide and flavonoid compound, and embodies the remarkable characteristics and technical progress of the formula. Meanwhile, the product has simple preparation process and low price. The product has the advantages of definite curative effect, no toxic or side effect, convenient taking and scientific dosage form, and embodies the practicability of the invention.
The invention also provides a remarkable contribution that all the raw materials are daily edible raw materials and raw materials used as both medicine and food, have no toxicity, and have very obvious effects of balancing yin and yang, adjusting nutrition structure, tonifying kidney, securing essence, enhancing capillary circulation, relieving or preventing nonpathogenic alopecia symptoms, promoting new hair and promoting hair follicle metabolism after being continuously taken every day. Embodies the synergistic interaction among the chemical components of the traditional Chinese medicine, starts with multiple targets and multiple parts, thereby achieving the effect of treatment and having the novelty and the innovation of the formula.
The other outstanding contribution of the invention lies in providing the drug effect of the medicinal liquor, and experimental results prove that the medicinal liquor has stronger and obvious activity compared with any single component in the formula, embodies the synergistic effect of the traditional Chinese medicine compound and has obvious technical progress and innovation.
The invention also aims to provide medicinal liquor for preventing and treating alopecia, which is prepared from the following Chinese medicinal raw materials in parts by weight: 10-80 parts of deer blood, 10-80 parts of ginseng, 10-100 parts of silkworm chrysalis, 1-8 parts of nutmeg, 8-64 parts of rhizoma polygonati, 8-64 parts of tangerine peel, 1-8 parts of red yeast rice, 5-40 parts of rock sugar and 500-4000 parts of white spirit; preferably, the traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 20-40 parts of deer blood, 20-40 parts of ginseng, 20-50 parts of silkworm chrysalis, 2-4 parts of nutmeg, 16-32 parts of rhizoma polygonati, 16-32 parts of tangerine peel, 2-4 parts of red yeast rice, 10-20 parts of rock sugar and 1000-3000 parts of white spirit.
The invention also aims to provide a preparation method of the medicinal liquor, which comprises the following steps:
a. pulverizing red yeast rice into fine powder;
b. drying pupa Bombycis under reduced pressure or freeze drying;
c. pulverizing Ginseng radix, semen Myristicae, rhizoma Polygonati, exocarpium Citri rubrum, and dried pupa bombycis into coarse powder, adding Chinese liquor, and percolating;
d. adding deer blood, red yeast rice powder and rock candy into the leakage liquid, stirring to dissolve, filtering, standing the filtrate at 0-10 ℃ for 12-48 hours, filtering, and canning the filtrate to obtain the product.
The preparation method of the anti-hair loss medicinal liquor provided by the invention is carried out by adopting a leakage method, does not adopt heating extraction, enables the medicinal liquor to be naturally balanced, does not generate precipitate after being placed for a long time, and is suitable for industrial mass production.
The invention discloses that the medicinal liquor prepared from the deer blood, the ginseng, the rhizoma polygonati, the silkworm chrysalis, the red tangerine peel, the nutmeg and the red yeast rice has the effect of preventing and treating alopecia for the first time.
The medicinal liquor (called medicinal liquor for short) prepared from deer blood, ginseng, sealwort, silkworm chrysalis, red tangerine peel, nutmeg and red yeast rice has the function of preventing and treating alopecia, and is proved by the following pharmacodynamic experiments.
1. Source of raw materials
Experiment raw materials: the medicinal liquor and the single extract used in the pharmacodynamics are provided by the inventor.
The deer blood mentioned in the pharmacodynamic test is obtained by freeze drying fresh deer blood; the Ginseng radix extract is obtained by extracting Ginseng radix with 8 times of 50% ethanol for 2 times, concentrating the extractive solution, and drying; the silkworm pupa extract is prepared by freeze drying fresh silkworm pupa, extracting with 8 times of 50% ethanol for 2 times, concentrating the extractive solution, and drying; the rhizoma Polygonati extract is obtained by extracting rhizoma Polygonati with 8 times of 50% ethanol for 2 times, concentrating the extractive solution, and drying; the exocarpium Citri rubrum extract is prepared by extracting exocarpium Citri rubrum with 8 times of 50% ethanol for 2 times, concentrating the extractive solution, and drying; the semen Myristicae extract is prepared by extracting semen Myristicae with 8 times of 50% ethanol for 2 times, concentrating the extractive solution, and drying; red Rice flour (purchased from Baoji Rundkang biology). The medicated wine for pharmacodynamic experiments is the medicated wine prepared in the example 1, and is obtained by concentrating and drying.
2. Grouping animals
120 male SD rats of SPF grade were selected and fed routinely. SD rats are numbered from 1 to 120 in sequence and then randomly grouped by looking up a random number table. The composition is divided into a medicinal liquor group A, a medicinal liquor group B, a medicinal liquor group C, a deer blood freeze-dried powder group, a red yeast rice powder group, a ginseng extract group, a silkworm pupa extract group, a rhizoma polygonati extract group, a red tangerine peel extract group, a nutmeg extract group, a blood-nourishing hair-growing capsule group (a positive control group) and a normal saline group (a negative control group) at random, and each group contains 10 capsules.
3. Preparation of the model
Mixing rosin and paraffin at a ratio of 1: 1, and continuously heating to 120 deg.C with an alcohol burner while stirring to completely dissolve. 120 SD male rats were head-marked with a 2cm by 2cm area of 5% picric acid one by one, and then each rat was intra-abdominally anesthetized with 4% chloral hydrate at a dose of 1m L/100g and fixed on a bench. Dipping the melted rosin paraffin solution by a cotton swab, staying in the air for 1-2 s, and coating the melted rosin paraffin solution on the region marked by picric acid. The integrated rat hair was stripped with vascular forceps, exposing pink hairless areas. After depilation, the plucked area was disinfected with 75% medical alcohol.
4. Methods of administration and dosages
From day 1 after molding, the administration was performed by gavage at the dose indicated in the table, 1 time per day.
5. Observation indicator and method
Performing intragastric administration on SD rats every day, observing the skin and hair growth conditions of the plucking area every day, and randomly measuring 10 mouse hairs in the plucking area by using a vernier caliper, wherein the length of each animal body hair is represented by the length of each animal body hair; on day 21 after molding, the rats were sacrificed by cervical dislocation, a piece of fur was taken from the original plucking area of the head by a punch with a diameter of 9mm, and skin specimens were fixed with 10% neutral formaldehyde, dehydrated, embedded in paraffin, serially sectioned, and HE-stained. Observation under an optical microscope: number of dermal superficial hair follicles (number): counting by 100 times of visual fields, counting 5 visual fields in each slice, and respectively calculating the average value; ② the number of dermal superficial capillaries (number): the mean was calculated at 200 field counts, 5 fields per slice.
6. Results of the experiment
6.1 comparison of Hair growth in groups of rats
TABLE 1 comparison of hair growth in groups of rats
P < 0.01, P < 0.05 compared to negative controls.
Compared with a negative control group, the difference of the high-dose group and the medium-low dose group of the medicinal liquor has significance on the 7 th day of administration, and compared with the negative control group, the difference of the high-dose group, the medium-dose group and the low-dose group and the positive control group on the 14 th day of administration has significance or very significance, and the difference is maintained to the end stage of the 21 st day experiment, which shows that the medicinal liquor can significantly promote the growth of the hair of the rat and prevent and treat alopecia. Compared with the single component in the formula, the medicinal liquor has more obvious activity.
6.2 comparison of the number of follicles and the number of vessels in the test area of rats in each group
TABLE 2 comparison of the number of hair follicles and the number of blood vessels in the test area of rats in each group
P < 0.01, P < 0.05 compared to negative controls.
Compared with the negative control group, the hair follicle numbers of the high, medium and low dose groups of the medicinal liquor have significant difference, and compared with the negative control group, the capillary blood vessel numbers of the high, medium and positive control groups have significant or very significant difference. The results show that the medicinal liquor can promote the regeneration of capillary vessels, improve local blood circulation, improve the nutrition of hair follicles and stimulate the regeneration of the hair follicles, thereby achieving the purpose of promoting the growth of the hair and preventing and treating alopecia. Compared with the single component in the formula, the medicinal liquor has more obvious activity.
From the above pharmacodynamic experiments, it is clear that the composition of the present invention has the effect of preventing and treating alopecia.
Detailed Description
The following describes embodiments of the present invention in further detail with reference to examples. The following examples are intended to illustrate the invention but are not intended to limit the scope of the invention.
EXAMPLE 1 preparation of medicated wine 1
Formulation of
Method for producing
a. Pulverizing red yeast rice into fine powder;
b. drying pupa Bombycis under reduced pressure or freeze drying;
c. pulverizing Ginseng radix, semen Myristicae, rhizoma Polygonati, exocarpium Citri rubrum, and dried pupa bombycis into coarse powder, adding 50% (v/v) Chinese liquor, and percolating;
d. adding deer blood, red rice powder and rock candy into the leakage solution, stirring to dissolve, filtering, standing the filtrate at 0-10 deg.C for 12-48 hr, filtering to obtain 2000ml, and canning.
EXAMPLE 2 preparation of medicated wine 2
Formulation of
Method for producing
a. Pulverizing red yeast rice into fine powder;
b. drying pupa Bombycis under reduced pressure or freeze drying;
c. pulverizing Ginseng radix, semen Myristicae, rhizoma Polygonati, exocarpium Citri rubrum, and dried pupa bombycis into coarse powder, adding 42% (v/v) Chinese liquor, and percolating;
d. adding deer blood, red rice powder and rock candy into the leakage solution, stirring to dissolve, filtering, standing the filtrate at 0-10 deg.C for 12-48 hr, filtering to obtain 2000ml, and canning.
Claims (7)
1. The medicinal liquor for preventing and treating alopecia is characterized by comprising the following raw materials in parts by weight:
10-80 parts of deer blood, 10-80 parts of ginseng, 10-100 parts of silkworm chrysalis, 1-8 parts of nutmeg, 8-64 parts of rhizoma polygonati, 8-64 parts of tangerine peel, 1-8 parts of red yeast rice, 5-40 parts of rock sugar and 500-4000 parts of white spirit.
2. The medicinal liquor for preventing and treating alopecia according to claim 1, is characterized by comprising the following raw materials in parts by weight:
20-40 parts of deer blood, 20-40 parts of ginseng, 20-50 parts of silkworm chrysalis, 2-4 parts of nutmeg, 16-32 parts of rhizoma polygonati, 16-32 parts of tangerine peel, 2-4 parts of red yeast rice, 10-20 parts of rock sugar and 1000-3000 parts of white spirit.
3. The preparation method of the medicinal liquor for preventing and treating alopecia according to claims 1-2, which is characterized by comprising the following steps:
a. pulverizing red yeast rice into fine powder;
b. drying pupa Bombycis under reduced pressure or freeze drying;
c. pulverizing Ginseng radix, semen Myristicae, rhizoma Polygonati, exocarpium Citri rubrum, and dried pupa bombycis into coarse powder, adding Chinese liquor, and percolating;
d. adding deer blood, red yeast rice powder and rock candy into the leakage liquid, stirring to dissolve, filtering, standing the filtrate at 0-10 ℃ for 12-48 hours, filtering, and canning the filtrate to obtain the product.
4. The medicated wine for preventing and treating alopecia according to claim 1, wherein the deer blood is fresh deer blood.
5. The medicated wine for preventing and treating alopecia according to claim 1, wherein the silkworm pupae are dry silkworm pupaes.
6. The medicated wine for preventing and treating alopecia according to claim 1, wherein the rhizoma polygonati is rhizoma polygonati preparata.
7. The medicated wine for preventing and treating alopecia according to any one of claims 1 to 6, characterized in that: the white spirit is pure grain white spirit with the alcohol content of 38-60 degrees.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1973862A (en) * | 2006-12-15 | 2007-06-06 | 王振华 | Externally applied hair restoring medicated wine |
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2021
- 2021-02-03 CN CN202110152605.2A patent/CN112717074B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1973862A (en) * | 2006-12-15 | 2007-06-06 | 王振华 | Externally applied hair restoring medicated wine |
Non-Patent Citations (1)
| Title |
|---|
| 徐伟祥，周政: "《实用进补手册》", 31 October 2001, 东方出版中心 * |
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