CN112691046A - Hawthorn extract neck wrinkle cream and preparation method thereof - Google Patents
Hawthorn extract neck wrinkle cream and preparation method thereof Download PDFInfo
- Publication number
- CN112691046A CN112691046A CN202110026777.5A CN202110026777A CN112691046A CN 112691046 A CN112691046 A CN 112691046A CN 202110026777 A CN202110026777 A CN 202110026777A CN 112691046 A CN112691046 A CN 112691046A
- Authority
- CN
- China
- Prior art keywords
- rutin
- copper
- cream
- hawthorn extract
- preparation
- Prior art date
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- Pending
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 37
- 235000020717 hawthorn extract Nutrition 0.000 title claims abstract description 35
- 230000037366 wrinkle cream Effects 0.000 title claims description 31
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 claims abstract description 110
- IVTMALDHFAHOGL-UHFFFAOYSA-N eriodictyol 7-O-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C=C3C(C(C(O)=C(O3)C=3C=C(O)C(O)=CC=3)=O)=C(O)C=2)O1 IVTMALDHFAHOGL-UHFFFAOYSA-N 0.000 claims abstract description 110
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 claims abstract description 110
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 claims abstract description 110
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 claims abstract description 110
- 235000005493 rutin Nutrition 0.000 claims abstract description 110
- 229960004555 rutoside Drugs 0.000 claims abstract description 110
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims abstract description 55
- 239000010949 copper Substances 0.000 claims abstract description 55
- 229910052802 copper Inorganic materials 0.000 claims abstract description 55
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 claims abstract description 31
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 claims abstract description 31
- 229940106189 ceramide Drugs 0.000 claims abstract description 31
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 claims abstract description 31
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 claims abstract description 31
- 238000006243 chemical reaction Methods 0.000 claims abstract description 23
- 239000006071 cream Substances 0.000 claims abstract description 19
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims description 39
- 238000003756 stirring Methods 0.000 claims description 37
- 238000000605 extraction Methods 0.000 claims description 35
- 238000010438 heat treatment Methods 0.000 claims description 32
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 31
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 26
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 25
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 15
- 238000005303 weighing Methods 0.000 claims description 15
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 claims description 14
- OPQARKPSCNTWTJ-UHFFFAOYSA-L copper(ii) acetate Chemical compound [Cu+2].CC([O-])=O.CC([O-])=O OPQARKPSCNTWTJ-UHFFFAOYSA-L 0.000 claims description 14
- 238000000967 suction filtration Methods 0.000 claims description 14
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 13
- 229930195729 fatty acid Natural products 0.000 claims description 13
- 239000000194 fatty acid Substances 0.000 claims description 13
- 150000004665 fatty acids Chemical class 0.000 claims description 13
- ARBOVOVUTSQWSS-UHFFFAOYSA-N hexadecanoyl chloride Chemical compound CCCCCCCCCCCCCCCC(Cl)=O ARBOVOVUTSQWSS-UHFFFAOYSA-N 0.000 claims description 13
- 238000002156 mixing Methods 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- FYFFGSSZFBZTAH-UHFFFAOYSA-N methylaminomethanetriol Chemical compound CNC(O)(O)O FYFFGSSZFBZTAH-UHFFFAOYSA-N 0.000 claims description 11
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 10
- 241001092040 Crataegus Species 0.000 claims description 10
- 235000009917 Crataegus X brevipes Nutrition 0.000 claims description 10
- 235000013204 Crataegus X haemacarpa Nutrition 0.000 claims description 10
- 235000009685 Crataegus X maligna Nutrition 0.000 claims description 10
- 235000009444 Crataegus X rubrocarnea Nutrition 0.000 claims description 10
- 235000009486 Crataegus bullatus Nutrition 0.000 claims description 10
- 235000017181 Crataegus chrysocarpa Nutrition 0.000 claims description 10
- 235000009682 Crataegus limnophila Nutrition 0.000 claims description 10
- 235000004423 Crataegus monogyna Nutrition 0.000 claims description 10
- 235000002313 Crataegus paludosa Nutrition 0.000 claims description 10
- 235000009840 Crataegus x incaedua Nutrition 0.000 claims description 10
- 238000011049 filling Methods 0.000 claims description 10
- 239000000843 powder Substances 0.000 claims description 10
- 239000003871 white petrolatum Substances 0.000 claims description 10
- 238000010992 reflux Methods 0.000 claims description 9
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 8
- 229960005323 phenoxyethanol Drugs 0.000 claims description 8
- 239000003755 preservative agent Substances 0.000 claims description 8
- 230000002335 preservative effect Effects 0.000 claims description 8
- 150000001875 compounds Chemical class 0.000 claims description 6
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims description 6
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 5
- 229910000881 Cu alloy Inorganic materials 0.000 claims description 5
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims description 5
- OQILCOQZDHPEAZ-UHFFFAOYSA-N Palmitinsaeure-octylester Natural products CCCCCCCCCCCCCCCC(=O)OCCCCCCCC OQILCOQZDHPEAZ-UHFFFAOYSA-N 0.000 claims description 5
- 238000001816 cooling Methods 0.000 claims description 5
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 claims description 5
- 239000008367 deionised water Substances 0.000 claims description 5
- 229910021641 deionized water Inorganic materials 0.000 claims description 5
- 238000001035 drying Methods 0.000 claims description 5
- GJQLBGWSDGMZKM-UHFFFAOYSA-N ethylhexyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(CC)CCCCC GJQLBGWSDGMZKM-UHFFFAOYSA-N 0.000 claims description 5
- FOYKKGHVWRFIBD-UHFFFAOYSA-N gamma-tocopherol acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 FOYKKGHVWRFIBD-UHFFFAOYSA-N 0.000 claims description 5
- KMZHZAAOEWVPSE-UHFFFAOYSA-N glycerol monoacetate Natural products CC(=O)OCC(O)CO KMZHZAAOEWVPSE-UHFFFAOYSA-N 0.000 claims description 5
- 229920002674 hyaluronan Polymers 0.000 claims description 5
- 229960003160 hyaluronic acid Drugs 0.000 claims description 5
- 229910052757 nitrogen Inorganic materials 0.000 claims description 5
- 238000007789 sealing Methods 0.000 claims description 5
- 239000007787 solid Substances 0.000 claims description 5
- 238000005406 washing Methods 0.000 claims description 5
- 230000037303 wrinkles Effects 0.000 claims description 5
- 239000002994 raw material Substances 0.000 claims description 4
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims description 3
- 229960004889 salicylic acid Drugs 0.000 claims description 3
- 239000002131 composite material Substances 0.000 claims 1
- 210000003491 skin Anatomy 0.000 abstract description 15
- 230000000694 effects Effects 0.000 abstract description 11
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract description 7
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 abstract description 6
- 230000002503 metabolic effect Effects 0.000 abstract description 6
- 150000003254 radicals Chemical class 0.000 abstract description 6
- 210000001835 viscera Anatomy 0.000 abstract description 6
- 230000032683 aging Effects 0.000 abstract description 5
- 210000002510 keratinocyte Anatomy 0.000 abstract description 5
- 102000004169 proteins and genes Human genes 0.000 abstract description 5
- 108090000623 proteins and genes Proteins 0.000 abstract description 5
- 239000002699 waste material Substances 0.000 abstract description 5
- 230000003110 anti-inflammatory effect Effects 0.000 abstract description 4
- 230000004888 barrier function Effects 0.000 abstract description 4
- 239000000126 substance Substances 0.000 abstract description 4
- 241000894006 Bacteria Species 0.000 abstract description 3
- 239000004310 lactic acid Substances 0.000 abstract description 3
- 235000014655 lactic acid Nutrition 0.000 abstract description 3
- 150000002632 lipids Chemical class 0.000 abstract description 3
- 210000002966 serum Anatomy 0.000 abstract description 3
- 230000003266 anti-allergic effect Effects 0.000 abstract description 2
- 230000004071 biological effect Effects 0.000 abstract description 2
- 230000002779 inactivation Effects 0.000 abstract description 2
- 239000011159 matrix material Substances 0.000 abstract description 2
- 229920001184 polypeptide Polymers 0.000 abstract description 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract description 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract description 2
- 101710088194 Dehydrogenase Proteins 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000035699 permeability Effects 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 16
- 230000000052 comparative effect Effects 0.000 description 9
- 210000000170 cell membrane Anatomy 0.000 description 5
- 235000007106 Crataegus suborbiculata Nutrition 0.000 description 4
- 241000073432 Crataegus suborbiculata Species 0.000 description 4
- 102000003855 L-lactate dehydrogenase Human genes 0.000 description 4
- 108700023483 L-lactate dehydrogenases Proteins 0.000 description 4
- 235000013202 a hawthorn Nutrition 0.000 description 4
- 230000008859 change Effects 0.000 description 4
- 235000019441 ethanol Nutrition 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 239000012466 permeate Substances 0.000 description 4
- 230000000630 rising effect Effects 0.000 description 4
- 102000008186 Collagen Human genes 0.000 description 3
- 108010035532 Collagen Proteins 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 229920001436 collagen Polymers 0.000 description 3
- HHEAADYXPMHMCT-UHFFFAOYSA-N dpph Chemical compound [O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1[N]N(C=1C=CC=CC=1)C1=CC=CC=C1 HHEAADYXPMHMCT-UHFFFAOYSA-N 0.000 description 3
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- 230000003859 lipid peroxidation Effects 0.000 description 2
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- 230000009467 reduction Effects 0.000 description 2
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 2
- WWUZIQQURGPMPG-UHFFFAOYSA-N (-)-D-erythro-Sphingosine Natural products CCCCCCCCCCCCCC=CC(O)C(N)CO WWUZIQQURGPMPG-UHFFFAOYSA-N 0.000 description 1
- DIGQNXIGRZPYDK-WKSCXVIASA-N (2R)-6-amino-2-[[2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-[[(2R,3S)-2-[[2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S,3S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[2-[[2-[[2-[(2-amino-1-hydroxyethylidene)amino]-3-carboxy-1-hydroxypropylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxybutylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1,5-dihydroxy-5-iminopentylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxybutylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxyethylidene]amino]hexanoic acid Chemical compound C[C@@H]([C@@H](C(=N[C@@H](CS)C(=N[C@@H](C)C(=N[C@@H](CO)C(=NCC(=N[C@@H](CCC(=N)O)C(=NC(CS)C(=N[C@H]([C@H](C)O)C(=N[C@H](CS)C(=N[C@H](CO)C(=NCC(=N[C@H](CS)C(=NCC(=N[C@H](CCCCN)C(=O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)N=C([C@H](CS)N=C([C@H](CO)N=C([C@H](CO)N=C([C@H](C)N=C(CN=C([C@H](CO)N=C([C@H](CS)N=C(CN=C(C(CS)N=C(C(CC(=O)O)N=C(CN)O)O)O)O)O)O)O)O)O)O)O)O DIGQNXIGRZPYDK-WKSCXVIASA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 102000003792 Metallothionein Human genes 0.000 description 1
- 108090000157 Metallothionein Proteins 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000005056 cell body Anatomy 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 230000019522 cellular metabolic process Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 229910001431 copper ion Inorganic materials 0.000 description 1
- 230000006003 cornification Effects 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- -1 hydroxyl radicals Chemical class 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
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- 239000013589 supplement Substances 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Emergency Medicine (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses hawthorn extract neck cream and a preparation method thereof. The formation of rutin copper changes the form of copper in vivo, acts with protein molecules of human body to enhance biological activity, reduces the inactivation of polypeptide, keeps stronger anti-inflammatory activity, effectively removes the free radical metabolic waste generated by reaction, and achieves the effect of resisting human body aging; after the human body strenuously exercises, excessive lactic acid is accumulated to cause the rise of lactic dehydrogenase in serum, and the rutin copper-azone compound can inhibit the rise of the substance, so that the organism can be quickly restored to a normal state, and the rutin copper-azone compound has certain protection and relieving effects on the internal organs of the organism; the hydroxyl in ceramide is covalently bonded with endogenous protein of cornified envelope, and lipid matrix is linked with keratinocytes to form a barrier to inhibit bacteria from entering, so as to achieve antiallergic effect, promote substance absorption, enhance permeability and moisten skin.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to hawthorn extract cervical wrinkle cream and a preparation method thereof.
Background
Cervical lines are caused by aging of epidermal cells and atrophy of connective tissue. The neck wrinkles of normal people are mainly caused by two reasons, namely, the aging of epidermal cells, the loss of vitality, the insufficient metabolism of cells, the reduction of water and the collapse of cell bodies; the second is atrophy of connective tissue, most predominantly manifested as a decrease in collagen. After the epidermal cells are aged, the metabolic capacity is insufficient, metabolic waste is easy to accumulate, and the copper ions in the rutin copper are combined with metallothionein of a human body to block the esterification and oxidation reaction of hydroxyl radicals, so that the free radical metabolic waste generated by the reaction is effectively removed, and the effect of resisting the aging of the human body is achieved. If skin is stimulated by the outside to cause insufficient supporting force of collagen fibers in the dermis layer of the skin or loss of collagen causes reduction of self-repairing capacity of the skin, wrinkles are formed, hydroxyl in ceramide can be covalently combined with internal protein in a cornification envelope of keratinocytes, lipid matrixes are linked with the keratinocytes to establish a barrier, so that harmful substances or bacteria are reduced from entering the skin, the ceramide can promote the skin to absorb the rutin copper-azone compound, and the rutin copper-azone compound can better permeate into an organism to moisten the skin.
Still contain rutin copper-azone complex in this kind of neck cream, can produce a large amount of lactic acid when the human body acutely moves and pile up, can not in time eliminate, internal lipid peroxidation degree risees and can lead to the fact certain influence to the internal organ simultaneously, the enzyme that originally is in the cell membrane inside can change because of the change of cell membrane, thereby release in to blood, cause the rising of lactate dehydrogenase in the serum from this, and above-mentioned complex just can restrain the rising of lactate dehydrogenase, let the organism more fast recover to normal condition, there is certain protection effect of releiving to organism viscera.
Therefore, it is very useful to design a neck wrinkle cream which not only can resist aging, but also can supplement water, prevent allergy and protect and relieve internal organs of the body.
Disclosure of Invention
The invention aims to provide hawthorn extract cervical wrinkle cream and a preparation method thereof, and aims to solve the problems in the background technology.
In order to solve the technical problems, the invention provides the following technical scheme: a hawthorn extract neck wrinkle cream and a preparation method thereof comprise the following raw materials in parts by weight:
30-40 parts of white vaseline, 20-30 parts of rutin copper, 15-20 parts of rutin copper-azone compound, 15-20 parts of ceramide, 10-15 parts of glycerol, 2-5 parts of preservative, 2-5 parts of essence and 30-40 parts of deionized water.
Preferably, the rutin copper is prepared by stirring rutin and absolute ethyl alcohol under the heating condition, adding copper acetate for refluxing, continuously stirring and carrying out suction filtration.
Preferably, the rutin copper-azone compound is prepared by heating rutin copper and azone for reaction.
Preferably, the ceramide is prepared by dissolving tris (hydroxymethyl) aminomethane in dimethyl formaldehyde, then dissolving in triethylamine, adding palmitoyl chloride after 30 minutes, carrying out a series of reactions, and then introducing fatty acid.
Preferably, the preservative is one of phenoxyethanol and salicylic acid.
The second aspect of the invention provides a hawthorn extract cervical wrinkle cream and a preparation method thereof, and the hawthorn extract cervical wrinkle cream comprises the following specific steps:
(1) preparation of rutin: mixing hawthorn powder and diatomite, and extracting by an extractor;
(2) preparing rutin copper: heating rutin and absolute ethyl alcohol for reaction, adding copper acetate for reaction, and performing suction filtration to obtain the rutin;
(3) preparing a rutin copper-azone compound: the rutin copper and the azone are heated and reacted to obtain the copper-based copper alloy;
(4) preparation of ceramide: the trihydroxymethyl aminomethane reacts with dimethyl formaldehyde and triethylamine, then palmitoyl chloride is added for reaction, and then fatty acid is introduced to prepare the compound;
(5) preparing hawthorn extract neck wrinkle cream: adding rutin copper, glycerol and tocopheryl acetate into white vaseline to carry out water bath heating, continuously stirring until the temperature is 75-85 ℃, then adding the rutin copper-azone compound and ethyl hexyl palmitate to continue stirring, adding ceramide, hyaluronic acid and phenoxyethanol to continue stirring after one hour until the temperature rises to 85-90 ℃, finally adding a certain amount of essence to stir uniformly, cooling to room temperature, and standing to obtain the hawthorn extract neck wrinkle cream.
Preferably, in the step (1): accurately weighing 10g of hawthorn powder and equivalent diatomite, uniformly mixing, filling into a 100ml extraction tank, filling a gap of the extraction tank with a proper amount of diatomite, sealing the extraction tank, putting the extraction tank and a collection bottle into an extraction instrument together, opening a nitrogen valve, controlling the partial pressure to be 0.8MPa, turning on a power supply, designing the preheating temperature to start preheating, adjusting parameters to start extraction, taking an extracting solution in a collection bottle after extraction is finished, and draining to obtain rutin.
Preferably, in the step (2): weighing 5g of rutin, adding 100ml of absolute ethyl alcohol, heating, stirring and dissolving to obtain a yellow solution, adding 3g of copper acetate into the solution for refluxing, continuing stirring for 5 hours, performing suction filtration, washing with 10ml of absolute ethyl alcohol, and drying to obtain light brown solid rutin copper.
Preferably, in the step (3): weighing 1.5% azone, heating, shaking, adding a small amount of rutin copper, and reacting under heating to obtain rutin copper-azone compound.
Preferably, in the step (4): dissolving trihydroxymethyl aminomethane in dimethyl formaldehyde, dissolving in triethylamine, adding palmitoyl chloride after 30min, reacting, and introducing fatty acid to obtain ceramide.
Compared with the prior art, the invention has the following beneficial effects:
rutin has anti-inflammatory, antiviral and antioxidant properties, copper is used as a necessary trace element in a human body and plays an important role in metabolism of the human body, copper acetate is added into the rutin dissolved in absolute ethyl alcohol to obtain the rutin copper through reflux suction filtration, the rutin copper and the copper are matched to have the pharmacological activities of the rutin copper and the copper, the form of the rutin copper in the human body is changed, the copper acts with protein molecules of the human body to enhance the biological activity, the inactivation of polypeptide is reduced, the stronger anti-inflammatory activity is kept, and the activity of the rutin in the human body is greatly enhanced to enhance the anti-inflammatory activity; hydroxyl free radicals in a human body have the highest toxicity, cell membranes can be damaged through esterification and oxidation reactions, cell death is caused, and free radical metabolic waste is generated.
Rutin copper and azone react to generate a rutin copper-azone compound, and the compound can enable the rutin copper to permeate into an organism more quickly, so that the efficiency of removing free radicals is higher, and a strong permeation-promoting and removing effect is achieved; can produce a large amount of lactic acid when the human body acutely moves and pile up, can not in time eliminate, internal lipid peroxidation degree risees simultaneously and can cause certain influence to the internal organ, and the enzyme that originally is in the cell membrane inside can change because of the change of cell membrane to release in the blood, cause the rising of lactate dehydrogenase in the serum from this, and above-mentioned complex just can restrain the rising of lactate dehydrogenase, lets the organism resume normal condition faster, has certain protection effect of releiving to organism internal organ.
Hydroxyl groups in the ceramide can be covalently bonded with endogenous proteins in the cornified envelope of the keratinocyte, and simultaneously, the lipid matrix is linked with the keratinocyte to establish a barrier, so that the barrier is firmer, harmful substances or bacteria are reduced from entering the skin, and an anti-allergy effect is achieved; the ceramide can promote the skin to absorb the rutin copper-azone compound, so that the rutin copper-azone compound can better permeate into the body and moisten the skin; the sphingosine carbon chain in the ceramide has double bonds, the hydroxyl groups in the ceramide are easy to oxidize to cause double bond breakage, and the rutin copper-azone compound can effectively inhibit the activity of the hydroxyl groups in the carbon chain and block the oxidation reaction of the hydroxyl groups.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The invention provides the technical scheme that: a hawthorn extract neck wrinkle cream and a preparation method thereof comprise the following raw materials in parts by weight:
30-40 parts of white vaseline, 20-30 parts of rutin copper, 15-20 parts of rutin copper-azone compound, 15-20 parts of ceramide, 10-15 parts of glycerol, 2-5 parts of preservative, 2-5 parts of essence and 30-40 parts of deionized water.
Preferably, the rutin copper is prepared by stirring rutin and absolute ethyl alcohol under the heating condition, adding copper acetate for refluxing, continuously stirring and carrying out suction filtration.
Preferably, the rutin copper-azone compound is prepared by heating rutin copper and azone for reaction.
Preferably, the ceramide is prepared by dissolving tris (hydroxymethyl) aminomethane in dimethyl formaldehyde, then dissolving in triethylamine, adding palmitoyl chloride after 30 minutes, carrying out a series of reactions, and then introducing fatty acid.
Preferably, the preservative is one of phenoxyethanol and salicylic acid.
The second aspect of the invention provides a hawthorn extract cervical wrinkle cream and a preparation method thereof, and the hawthorn extract cervical wrinkle cream comprises the following specific steps:
(1) preparation of rutin: mixing hawthorn powder and diatomite, and extracting by an extractor;
(2) preparing rutin copper: heating rutin and absolute ethyl alcohol for reaction, adding copper acetate for reaction, and performing suction filtration to obtain the rutin;
(3) preparing a rutin copper-azone compound: the rutin copper and the azone are heated and reacted to obtain the copper-based copper alloy;
(4) preparation of ceramide: the trihydroxymethyl aminomethane reacts with dimethyl formaldehyde and triethylamine, then palmitoyl chloride is added for reaction, and then fatty acid is introduced to prepare the compound;
(5) preparing hawthorn extract neck wrinkle cream: adding rutin copper, glycerol and tocopheryl acetate into white vaseline to carry out water bath heating, continuously stirring until the temperature is 75-85 ℃, then adding the rutin copper-azone compound and ethyl hexyl palmitate to continue stirring, adding ceramide, hyaluronic acid and phenoxyethanol to continue stirring after one hour until the temperature rises to 85-90 ℃, finally adding a certain amount of essence to stir uniformly, cooling to room temperature, and standing to obtain the hawthorn extract neck wrinkle cream.
Preferably, in the step (1): accurately weighing 10g of hawthorn powder and equivalent diatomite, uniformly mixing, filling into a 100ml extraction tank, filling a gap of the extraction tank with a proper amount of diatomite, sealing the extraction tank, putting the extraction tank and a collection bottle into an extraction instrument together, opening a nitrogen valve, controlling the partial pressure to be 0.8MPa, turning on a power supply, designing the preheating temperature to start preheating, adjusting parameters to start extraction, taking an extracting solution in a collection bottle after extraction is finished, and draining to obtain rutin.
Preferably, in the step (2): weighing 5g of rutin, adding 100ml of absolute ethyl alcohol, heating, stirring and dissolving to obtain a yellow solution, adding 3g of copper acetate into the solution for refluxing, continuing stirring for 5 hours, performing suction filtration, washing with 10ml of absolute ethyl alcohol, and drying to obtain light brown solid rutin copper.
Preferably, in the step (3): weighing 1.5% azone, heating, shaking, adding a small amount of rutin copper, and reacting under heating to obtain rutin copper-azone compound.
Preferably, in the step (4): dissolving trihydroxymethyl aminomethane in dimethyl formaldehyde, dissolving in triethylamine, adding palmitoyl chloride after 30min, reacting, and introducing fatty acid to obtain ceramide.
Example 1: hawthorn extract neck wrinkle cream one:
30 parts of white vaseline, 20 parts of rutin copper, 15 parts of rutin copper-azone compound, 15 parts of ceramide, 10 parts of glycerol, 2 parts of preservative, 2 parts of essence and 30 parts of deionized water.
The preparation method of the neck wrinkle cream comprises the following steps:
(1) preparation of rutin: mixing hawthorn powder and diatomite, and extracting by an extractor;
(2) preparing rutin copper: heating rutin and absolute ethyl alcohol for reaction, adding copper acetate for reaction, and performing suction filtration to obtain the rutin;
(3) preparing a rutin copper-azone compound: the rutin copper and the azone are heated and reacted to obtain the copper-based copper alloy;
(4) preparation of ceramide: the trihydroxymethyl aminomethane reacts with dimethyl formaldehyde and triethylamine, then palmitoyl chloride is added for reaction, and then fatty acid is introduced to prepare the compound;
(5) preparing hawthorn extract neck wrinkle cream: adding rutin copper, glycerol and tocopheryl acetate into white vaseline for heating in water bath, continuously stirring until the temperature is heated to 75 ℃, adding rutin copper-azone compound and ethyl hexyl palmitate for continuously stirring, adding ceramide, hyaluronic acid and phenoxyethanol for continuously stirring after one hour until the temperature is increased to 85 ℃, finally adding a certain amount of essence for uniformly stirring, cooling to room temperature, and standing to obtain the hawthorn extract neck wrinkle cream.
Preferably, in the step (1): accurately weighing 10g of hawthorn powder and equivalent diatomite, uniformly mixing, filling into a 100ml extraction tank, filling a gap of the extraction tank with a proper amount of diatomite, sealing the extraction tank, putting the extraction tank and a collection bottle into an extraction instrument together, opening a nitrogen valve, controlling the partial pressure to be 0.8MPa, turning on a power supply, designing the preheating temperature to start preheating, adjusting parameters to start extraction, taking an extracting solution in a collection bottle after extraction is finished, and draining to obtain rutin.
Preferably, in the step (2): weighing 5g of rutin, adding 100ml of absolute ethyl alcohol, heating, stirring and dissolving to obtain a yellow solution, adding 3g of copper acetate into the solution for refluxing, continuing stirring for 5 hours, performing suction filtration, washing with 10ml of absolute ethyl alcohol, and drying to obtain light brown solid rutin copper.
Preferably, in the step (3): weighing 1.5% azone, heating, shaking, adding a small amount of rutin copper, and reacting under heating to obtain rutin copper-azone compound.
Preferably, in the step (4): dissolving trihydroxymethyl aminomethane in dimethyl formaldehyde, dissolving in triethylamine, adding palmitoyl chloride after 30min, reacting, and introducing fatty acid to obtain ceramide.
Example 2: and (2) hawthorn extract neck wrinkle cream II:
37 parts of white vaseline, 27 parts of rutin copper, 17 parts of rutin copper-azone compound, 17 parts of ceramide, 13 parts of glycerol, 4 parts of preservative, 4 parts of essence and 37 parts of deionized water.
The preparation method of the neck wrinkle cream comprises the following steps:
(1) preparation of rutin: mixing hawthorn powder and diatomite, and extracting by an extractor;
(2) preparing rutin copper: heating rutin and absolute ethyl alcohol for reaction, adding copper acetate for reaction, and performing suction filtration to obtain the rutin;
(3) preparing a rutin copper-azone compound: the rutin copper and the azone are heated and reacted to obtain the copper-based copper alloy;
(4) preparation of ceramide: the trihydroxymethyl aminomethane reacts with dimethyl formaldehyde and triethylamine, then palmitoyl chloride is added for reaction, and then fatty acid is introduced to prepare the compound;
(5) preparing hawthorn extract neck wrinkle cream: adding rutin copper, glycerol and tocopheryl acetate into white vaseline for heating in water bath, continuously stirring until the temperature is 85 ℃, adding rutin copper-azone compound and ethyl hexyl palmitate for continuously stirring, adding ceramide, hyaluronic acid and phenoxyethanol for continuously stirring after one hour until the temperature is increased to 90 ℃, finally adding a certain amount of essence for uniformly stirring, cooling to room temperature, and standing to obtain the hawthorn extract neck wrinkle cream.
Preferably, in the step (1): accurately weighing 10g of hawthorn powder and equivalent diatomite, uniformly mixing, filling into a 100ml extraction tank, filling a gap of the extraction tank with a proper amount of diatomite, sealing the extraction tank, putting the extraction tank and a collection bottle into an extraction instrument together, opening a nitrogen valve, controlling the partial pressure to be 0.8MPa, turning on a power supply, designing the preheating temperature to start preheating, adjusting parameters to start extraction, taking an extracting solution in a collection bottle after extraction is finished, and draining to obtain rutin.
Preferably, in the step (2): weighing 5g of rutin, adding 100ml of absolute ethyl alcohol, heating, stirring and dissolving to obtain a yellow solution, adding 3g of copper acetate into the solution for refluxing, continuing stirring for 5 hours, performing suction filtration, washing with 10ml of absolute ethyl alcohol, and drying to obtain light brown solid rutin copper.
Preferably, in the step (3): weighing 1.5% azone, heating, shaking, adding a small amount of rutin copper, and reacting under heating to obtain rutin copper-azone compound.
Preferably, in the step (4): dissolving trihydroxymethyl aminomethane in dimethyl formaldehyde, dissolving in triethylamine, adding palmitoyl chloride after 30min, reacting, and introducing fatty acid to obtain ceramide.
Comparative example 1:
the preparation method of the common neck wrinkle cream comprises the following steps: mixing various raw materials with various reagents, heating, stirring, adding a certain amount of essence and antiseptic, and standing at constant temperature.
Comparative example 2:
comparative example 2 was formulated as in example 1. The preparation method of the neck cream is different from that of the example 1 only in that the preparation of the step (2) is not carried out, and the rest of the preparation steps are the same as the example 1.
Comparative example 3:
the formulation of comparative example 3 was the same as example 1. The preparation method of the neck cream is different from that of the example 1 only in that the preparation of the step (4) is not carried out, and the rest of the preparation steps are the same as the example 1.
Test example 1
10 women of comparable age and similar skin condition were selected and the current skin moisture content was first recorded and again measured after 30 days of continued use of the product, as shown in the following table:
as is apparent from the comparison in the above table, the moisture content of the skin is greatly increased after the hawthorn extract neck cream in the embodiment 1 is used, and it is the ceramide in the neck cream which can promote the skin to absorb the rutin copper-azone compound, so that the rutin copper-azone compound can better permeate into the body, and the effect of moisturizing the skin is achieved.
Test example 2
DPPH 20mg was weighed out accurately and made up to 500mL with 95% ethanol. Taking 2mL of prepared DPPH solution, respectively adding 1mL of fructus crataegi extract neck wrinkle cream prepared in example 1, common facial cream in comparative example 1, and fructus crataegi extract neck wrinkle cream with less rutin copper in comparative example 3, adding 95% ethanol to 4mL, mixing, standing for 30min, and measuring absorbance A at wavelength of 500nm1. Adding 2mL of 95% ethanol into the hydrolysateReplacement of DPPH solution A2. Adding 1ml of ethanol as reference solution A into blank control solutioncThe clearance is calculated according to the formula:
clearance (%) - (1- (A)1-A2)/Ac]*100
| Clearance rate% | |
| Example 1 | 70％ |
| Comparative example 1 | 30％ |
| Comparative example 2 | 50％ |
As is apparent from the above table, the hawthorn extract cream of example 1 can effectively remove the metabolic wastes of free radicals, thereby achieving the effect of anti-aging.
It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that changes may be made in the embodiments and/or equivalents thereof without departing from the spirit and scope of the invention. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. A hawthorn extract neck wrinkle cream and a preparation method thereof are characterized in that: the composite material comprises the following raw materials in parts by weight: 30-40 parts of white vaseline, 20-30 parts of rutin copper, 15-20 parts of rutin copper-azone compound, 15-20 parts of ceramide, 10-15 parts of glycerol, 2-5 parts of preservative, 2-5 parts of essence and 30-40 parts of deionized water.
2. The hawthorn extract neck cream and the preparation method thereof according to claim 1, wherein the hawthorn extract neck cream is characterized in that: the rutin copper is prepared by stirring rutin and absolute ethyl alcohol under the heating condition, adding copper acetate for refluxing, continuously stirring and carrying out suction filtration.
3. The hawthorn extract neck cream and the preparation method thereof according to claim 2, wherein the hawthorn extract neck cream is characterized in that: the rutin copper-azone compound is prepared by heating rutin copper and azone for reaction.
4. The hawthorn extract neck cream and the preparation method thereof according to claim 3, wherein the hawthorn extract neck cream is characterized in that: the ceramide is prepared by dissolving trihydroxymethyl aminomethane in dimethyl formaldehyde, dissolving in triethylamine, adding palmitoyl chloride after 30 minutes, carrying out a series of reactions, and introducing fatty acid.
5. The hawthorn extract neck cream and the preparation method thereof according to claim 4, wherein the hawthorn extract neck cream is characterized in that: the preservative is one of phenoxyethanol and salicylic acid.
6. The hawthorn extract cervical wrinkle cream is characterized by comprising the following specific steps:
(1) preparation of rutin: mixing hawthorn powder and diatomite, and extracting by an extractor;
(2) preparing rutin copper: heating rutin and absolute ethyl alcohol for reaction, adding copper acetate for reaction, and performing suction filtration to obtain the rutin;
(3) preparing a rutin copper-azone compound: the rutin copper and the azone are heated and reacted to obtain the copper-based copper alloy;
(4) preparation of ceramide: the trihydroxymethyl aminomethane reacts with dimethyl formaldehyde and triethylamine, then palmitoyl chloride is added for reaction, and then fatty acid is introduced to prepare the compound;
(5) preparing hawthorn extract neck wrinkle cream: adding rutin copper, glycerol and tocopheryl acetate into white vaseline to carry out water bath heating, continuously stirring until the temperature is 75-85 ℃, then adding the rutin copper-azone compound and ethyl hexyl palmitate to continue stirring, adding ceramide, hyaluronic acid and phenoxyethanol to continue stirring after one hour until the temperature rises to 85-90 ℃, finally adding a certain amount of essence to stir uniformly, cooling to room temperature, and standing to obtain the hawthorn extract neck wrinkle cream.
7. The hawthorn extract cervical wrinkle cream and the preparation method thereof according to claim 6, wherein in the step (1): accurately weighing 10g of hawthorn powder and equivalent diatomite, uniformly mixing, filling into a 100ml extraction tank, filling a gap of the extraction tank with a proper amount of diatomite, sealing the extraction tank, putting the extraction tank and a collection bottle into an extraction instrument together, opening a nitrogen valve, controlling the partial pressure to be 0.8MPa, turning on a power supply, designing the preheating temperature to start preheating, adjusting parameters to start extraction, taking an extracting solution in a collection bottle after extraction is finished, and draining to obtain rutin.
8. The hawthorn extract cream for relieving cervical wrinkles and the preparation method thereof according to claim 7, wherein in the step (2): weighing 5g of rutin, adding 100ml of absolute ethyl alcohol, heating, stirring and dissolving to obtain a yellow solution, adding 3g of copper acetate into the solution for refluxing, continuing stirring for 5 hours, performing suction filtration, washing with 10ml of absolute ethyl alcohol, and drying to obtain light brown solid rutin copper.
9. The hawthorn extract cream for relieving cervical wrinkles and the preparation method thereof according to claim 8, wherein in the step (3): weighing 1.5% azone, heating, shaking, adding a small amount of rutin copper, and reacting under heating to obtain rutin copper-azone compound.
10. The hawthorn extract cream for relieving cervical wrinkles and the preparation method thereof according to claim 9, wherein in the step (4): dissolving trihydroxymethyl aminomethane in dimethyl formaldehyde, dissolving in triethylamine, adding palmitoyl chloride after 30min, reacting, and introducing fatty acid to obtain ceramide.
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| CN102824431A (en) * | 2012-09-06 | 2012-12-19 | 河北科技师范学院 | Method for extracting hawthorn flavone by using pressurized liquid extraction (APLE) technique |
| CN109528546A (en) * | 2019-01-13 | 2019-03-29 | 崔星海 | Has effects that crease-resistant cosmetic composition and preparation method thereof |
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2021
- 2021-01-09 CN CN202110026777.5A patent/CN112691046A/en active Pending
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| CN102824431A (en) * | 2012-09-06 | 2012-12-19 | 河北科技师范学院 | Method for extracting hawthorn flavone by using pressurized liquid extraction (APLE) technique |
| CN109528546A (en) * | 2019-01-13 | 2019-03-29 | 崔星海 | Has effects that crease-resistant cosmetic composition and preparation method thereof |
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