CN112673025A - 一种包含第三信号受体的嵌合抗原受体及其应用 - Google Patents

一种包含第三信号受体的嵌合抗原受体及其应用 Download PDF

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CN112673025A
CN112673025A CN201980041282.0A CN201980041282A CN112673025A CN 112673025 A CN112673025 A CN 112673025A CN 201980041282 A CN201980041282 A CN 201980041282A CN 112673025 A CN112673025 A CN 112673025A
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CN112673025B (zh
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杨选明
傅阳心
汪鑫
叶圣勤
李民
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Shanghai Longyao Biotechnology Co ltd
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Abstract

本发明提供了一种结构为scFv(X)‑(Y)CD3zeta‑MN的嵌合抗原受体；其中，X包括肿瘤靶向抗体或能与肿瘤特异结合的配体、受体；Y为共刺激受体的胞内区，所述共刺激受体选自ICOS、CD28、CD27、HVEM、LIGHT、CD40L、4‑1BB、OX40、DR3、GITR、CD30、TIM1、SLAM、CD2、CD226；M为gamma chain家族细胞因子受体的胞内区，所述细胞因子受体选自IL2Ra、IL2Rb、IL4Ra、IL7Ra、IL9Ra、IL15Ra、IL21Ra；N为IL2Rg胞内区。本发明还提供了由上述嵌合抗原受体的重组表达载体构建的CAR‑T细胞及其制备方法和应用。本发明所述的CAR‑T细胞显著提高了肿瘤杀伤能力和扩增能力。

Description

PCT国内申请，说明书已公开。

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  1. PCT国内申请，权利要求书已公开。
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CN117402231A (zh) * 2023-12-14 2024-01-16 南方医科大学南方医院 一种自发传递il-21信号的受体及其应用

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CN110615843B (zh) * 2018-06-20 2023-05-09 上海隆耀生物科技有限公司 一种包含第三信号受体的嵌合抗原受体及其应用
CN111269326A (zh) * 2020-02-28 2020-06-12 南京北恒生物科技有限公司 新型嵌合抗原受体及其用途
EP4132973A4 (en) * 2020-04-06 2024-06-12 Celledit LLC GENETICALLY ENGINEERED IMMUNE CELLS EXPRESSING A CHIMERIC ANTIGEN RECEPTOR AND HAVING REDUCED PRO-INFLAMMATORY CYTOKINE SIGNALING
CN111518219B (zh) * 2020-05-08 2021-06-22 浙江大学 嵌合性抗原受体及表达其的巨噬细胞、调节巨噬细胞极化的方法和应用
CN112062864A (zh) * 2020-09-18 2020-12-11 樊克兴 靶向bcma肿瘤抗原受体修饰t细胞的制备方法和应用
WO2023274355A1 (zh) * 2021-07-02 2023-01-05 上海交通大学 改造的间充质干细胞和免疫效应细胞联合治疗肿瘤
AU2022346040A1 (en) * 2021-09-17 2024-03-14 The Board Of Trustees Of The Leland Stanford Junior University Chimeric antigen receptors comprising interleukin-9 receptor signaling domain
WO2023133361A2 (en) * 2022-01-10 2023-07-13 Phenomic Ai Anti-cthrc1 fusion proteins and methods of using the same

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