CN112640958A - Nutritional goat milk powder suitable for diarrhea children and preparation method and application thereof - Google Patents

Nutritional goat milk powder suitable for diarrhea children and preparation method and application thereof Download PDF

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Publication number
CN112640958A
CN112640958A CN202011557257.9A CN202011557257A CN112640958A CN 112640958 A CN112640958 A CN 112640958A CN 202011557257 A CN202011557257 A CN 202011557257A CN 112640958 A CN112640958 A CN 112640958A
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powder
diarrhea
children
goat milk
nutritional
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Inventor
袁庆彬
薛玉玲
王世杰
贾晓江
冯丽莉
张栋
荀一萍
封肖颖
刘建光
朱素芳
刘海荣
陈建行
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Shijiazhuang Junlebao Dairy Co Ltd
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Shijiazhuang Junlebao Dairy Co Ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/16—Agglomerating or granulating milk powder; Making instant milk powder; Products obtained thereby
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
    • A23C9/123—Fermented milk preparations; Treatment using microorganisms or enzymes using only microorganisms of the genus lactobacteriaceae; Yoghurt
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
    • A23C9/123—Fermented milk preparations; Treatment using microorganisms or enzymes using only microorganisms of the genus lactobacteriaceae; Yoghurt
    • A23C9/1234—Fermented milk preparations; Treatment using microorganisms or enzymes using only microorganisms of the genus lactobacteriaceae; Yoghurt characterised by using a Lactobacillus sp. other than Lactobacillus Bulgaricus, including Bificlobacterium sp.
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
    • A23C9/13—Fermented milk preparations; Treatment using microorganisms or enzymes using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
    • A23C9/13—Fermented milk preparations; Treatment using microorganisms or enzymes using additives
    • A23C9/1307—Milk products or derivatives; Fruit or vegetable juices; Sugars, sugar alcohols, sweeteners; Oligosaccharides; Organic acids or salts thereof or acidifying agents; Flavours, dyes or pigments; Inert or aerosol gases; Carbonation methods
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
    • A23C9/13—Fermented milk preparations; Treatment using microorganisms or enzymes using additives
    • A23C9/1315—Non-milk proteins or fats; Seeds, pulses, cereals or soja; Fatty acids, phospholipids, mono- or diglycerides or derivatives therefrom; Egg products
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
    • A23C9/13—Fermented milk preparations; Treatment using microorganisms or enzymes using additives
    • A23C9/1322—Inorganic compounds; Minerals, including organic salts thereof, oligo-elements; Amino-acids, peptides, protein-hydrolysates or derivatives; Nucleic acids or derivatives; Yeast extract or autolysate; Vitamins; Antibiotics; Bacteriocins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
    • A23C9/13—Fermented milk preparations; Treatment using microorganisms or enzymes using additives
    • A23C9/133—Fruit or vegetables
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2400/00—Lactic or propionic acid bacteria
    • A23V2400/11—Lactobacillus
    • A23V2400/165—Paracasei
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2400/00—Lactic or propionic acid bacteria
    • A23V2400/11—Lactobacillus
    • A23V2400/175—Rhamnosus
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2400/00—Lactic or propionic acid bacteria
    • A23V2400/21—Streptococcus, lactococcus
    • A23V2400/249—Thermophilus
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2400/00—Lactic or propionic acid bacteria
    • A23V2400/51—Bifidobacterium
    • A23V2400/515—Animalis

Abstract

The invention belongs to the field of dairy products, and discloses nutritional goat milk powder suitable for children with diarrhea and a preparation method and application thereof. The nutritional goat milk powder is more suitable for diarrhea children to eat by adjusting the preparation process, adding a plurality of components in reasonable proportion and utilizing the synergistic interaction among the components, and is used for adjuvant treatment and alleviation of diarrhea symptoms.

Description

Nutritional goat milk powder suitable for diarrhea children and preparation method and application thereof
Technical Field
The invention belongs to the field of dairy products, and relates to child milk powder, in particular to nutritional goat milk powder suitable for children with diarrhea and a preparation method and application thereof.
Background
Diarrhea is the most common digestive disorder in children. Because the immune system and the digestive system of children are immature, diarrhea is easily caused by infection of viruses and bacteria, food allergy, lactose intolerance or dyspepsia and the like. Frequent diarrhea in children causes malnutrition, slow growth and even dehydration, which is life threatening, and care must be taken. During the nursing period, children are required to take easily absorbable, flatulence-free, low-sugar and low-fat foods, but sufficient nutrition is also required to promote the recovery of children, so that the diet nursing of diarrhea becomes a problem.
At present, however, the diet of diarrhea children is mainly light and digestible porridge food, and the targeted food is few; the formula milk powder suitable for children with diarrhea is also mainly milk powder, has large protein particles and large fat particles, is not easy to absorb than goat milk powder, has heavy goat milk powder smell, and is not favored by children; at present, the milk powder is improved for children with diarrhea, the lactose content is reduced so as to relieve lactose intolerance, and the intestinal microenvironment of the children with diarrhea is not conditioned.
Therefore, according to the nutritional requirements and taste preference of the diarrhea children, the nutritional goat milk powder which is easy to absorb, has small mutton smell, can condition intestinal microenvironment and improve diarrhea symptoms and is suitable for the diarrhea children is developed, and the nutritional goat milk powder is beneficial to promoting the diarrhea children to recover as soon as possible and avoiding the further development of the disease condition.
Disclosure of Invention
The invention aims to provide nutritional goat milk powder suitable for diarrhea children to meet the nutritional requirements and taste preference of the diarrhea children, and achieve the purposes of easy absorption, conditioning intestinal microenvironment of the diarrhea children and improving diarrhea symptoms;
the invention also aims to provide a preparation method of the nutritional goat milk powder suitable for children with diarrhea;
the invention also aims to provide an application of the nutritional goat milk powder suitable for children with diarrhea.
In order to achieve the purpose, the invention adopts the technical scheme that:
the nutritious goat milk powder suitable for diarrhea children comprises the following raw materials of effective components in parts by weight:
350 parts of goat milk, 50-70 parts of whey protein powder, 0.6-0.9 part of phospholipid, 0.6-0.9 part of calcium carbonate, 0.17-0.25 part of choline chloride, 0.3-0.4 part of compound vitamin, 0.2-0.25 part of compound mineral, 7.21-8.7 parts of nutrition supplementing powder, 2-3 parts of compound bacteria powder and 2-3 parts of water;
the whey protein powder is rich in milk fat globule membrane protein;
the goat milk was accepted, pasteurized and homogenized.
As a limitation, the compound vitamin is formed by mixing vitamin A, vitamin D, vitamin E, vitamin C and vitamin B in a weight ratio of 5-6:42-43:8:0.01: 45;
the vitamin B is prepared by mixing vitamin B1, vitamin B2, vitamin B6, vitamin B12, nicotinamide, folic acid and pantothenic acid in a weight ratio of 0.8:1.6:0.7:0.005:6:0.14: 4.4.
As another limitation, the composite mineral is formed by mixing magnesium sulfate, ferrous sulfate and zinc sulfate in a weight ratio of 4-6:1: 1.
As a third limitation, the nutritional supplement powder is prepared by mixing rhizoma dioscoreae powder, poria cocos powder, japonica rice powder, millet powder, carrot powder and white hyacinth bean powder in a weight ratio of 3-5:1:1-2:5:3: 2.
As a fourth limitation, the composite bacterial powder is active freeze-dried bacterial powder and is prepared by mixing four probiotic bacterial powders, namely lactobacillus paracasei N1115 bacterial powder, bifidobacterium animalis bacterial powder, streptococcus thermophilus bacterial powder JMCC0024 and lactobacillus rhamnosus bacterial powder in a weight ratio of 2-3:1:1-2: 1.
The Lactobacillus paracasei N1115(Lactobacillus paracasei N1115) used in the invention is preserved in 17.3.2011 in China general microbiological culture collection center (the national patent microorganism collection center designated by the patent office) of China microbiological culture collection management Committee No. 3 of the Xilu No.1 Hospital, Beijing, and the preservation numbers are as follows: CGMCC NO.4691, which is disclosed for the first time in Chinese invention patent with the patent number of 201110357058.8;
the Streptococcus thermophilus JMCC0024(Streptococcus thermophilus JMCC0024) used in the invention is preserved in 14 days 12 months in 2018 at the China general microbiological culture collection center of China microbiological culture collection management committee, China institute No.1, west way, No. 3, located in the area of the south of the republic of Beijing, the preservation address is that the preservation number is CGMCC NO. 16975.
As a further limitation, the nutritional goat milk powder suitable for children with diarrhea is characterized in that the total number of bacterial colonies of the four probiotics in the composite bacterial powder is 1 multiplied by 1012-1.3×1012CFU/g。
The invention also provides a preparation method of the nutritional goat milk powder suitable for diarrhea children, which comprises the following steps in sequence:
firstly, adding 50-70% of composite bacteria powder and nutrition supplementing powder into goat milk, dissolving and fermenting to obtain a mixed material I;
dissolving choline chloride, compound mineral substances and calcium carbonate in water to obtain a mixed material II;
② uniformly mixing the whey protein powder, the phospholipid, the mixture I and the mixture II, homogenizing, spray-drying, cooling, adding the compound vitamin and the rest of the compound bacteria powder, and uniformly mixing by a dry method to obtain the nutritional goat milk powder suitable for the diarrhea children.
As a limitation, in the step (i), the fermentation temperature is 37-43 ℃ and the fermentation time is 4-5 h;
in the step II, the pressure of homogenization is 190-210 bar;
the spray pressure of the spray drying is 240bar minus 180 DEG plus, the air inlet temperature is 170 DEG plus 150 DEG plus, the air exhaust temperature is 85-90 DEG plus, and the pressure in the drying chamber is-110-90 Pa.
The invention also provides an application of the nutritional goat milk powder suitable for diarrhea children, and the nutritional goat milk powder suitable for diarrhea children is suitable for diarrhea children, and is used for adjuvant therapy and alleviation of diarrhea symptoms.
Due to the adoption of the technical scheme, compared with the prior art, the invention has the technical progress that:
(1) according to the preparation method, in the step I, the goat milk, the compound bacteria powder and the nutrition supplementing powder are fermented, so that lactose and fat in the goat milk and substances which are not easy to digest, such as saccharides and fat in the nutrition supplementing powder are further decomposed, and more absorbable nutritional ingredients are obtained, so that the goat milk is suitable for diarrhea children to eat, the mutton smell of the goat milk is reduced, the sensory quality of the product is improved, and the taste preference of the children is met;
as the powder spraying and high temperature in the spray drying process can cause partial inactivation of the composite bacteria powder, in the second step, the composite bacteria powder is added again to ensure the content of the probiotics in the final product;
(2) according to the invention, the compound bacterial powder with a reasonable ratio is added, wherein the lactobacillus paracasei N1115, the bifidobacterium animalis, the streptococcus thermophilus and the lactobacillus rhamnosus have a synergistic effect, so that harmful bacteria in intestinal tracts are inhibited, the hepcidin level in the intestinal tracts is regulated, and the intestinal tract function recovery is promoted;
(3) according to the physical conditions of children with diarrhea, the compound vitamins and the compound minerals in reasonable proportion are added to supplement the loss of inorganic salts and minerals caused by diarrhea; the added whey protein powder is rich in milk fat globule membrane protein, is combined with probiotics in the added compound bacteria powder, promotes the colonization and the play of the probiotics in the intestinal tract, and meanwhile, the milk fat globule membrane protein also has the effect of inhibiting the colonization of harmful bacteria in the intestinal tract, and helps to regulate the steady state of the microenvironment in the intestinal tract of the diarrhea children;
(4) the nutrition supplementing powder with reasonable proportion is added to supplement nutrition required by children with diarrhea, inhibit harmful microorganisms in intestinal tract and promote intestinal recovery; meanwhile, the nutritional supplement interacts with the composite bacteria powder, so that on one hand, the absorption effect of the nutritional supplement is improved, on the other hand, the activity of probiotics is maintained, and the function of the probiotics is promoted;
(5) the yam powder is added as a medicine-food homologous food, can tonify spleen and nourish stomach, promote the production of body fluid and benefit lung, has the effects of tonifying kidney and arresting seminal emission, clearing heat and detoxifying, and plays a role in improving the conditions of spleen deficiency and poor appetite or chronic diarrhea; meanwhile, the common yam rhizome is rich in mucin and can protect probiotics;
the added white hyacinth bean powder has rich nutrition and high medicinal value, has the effects of nourishing, recuperating, treating diarrhea and dysentery, and inhibiting viruses, but can cause abdominal distension when being directly eaten, and reduces the risk of causing abdominal distension by fermenting the white hyacinth bean powder;
the added carrot powder is rich in pectin, can promote stool formation, adsorb bacteria and toxin on intestinal mucosa, and can promote the proliferation of probiotics;
because the temperature in the spray drying process is higher, the added japonica rice powder is carbonized after spray drying, and the carbonized structure of the japonica rice powder has better adsorption and antidiarrheal effects; meanwhile, the polished round-grained rice has the effects of strengthening the spleen and stomach, tonifying middle-jiao and Qi, removing polydipsia, stopping diarrhea and dysentery, and is suitable for children with diarrhea;
(6) compared with cow milk, the goat milk adopted by the invention has higher calcium, potassium, magnesium and zinc contents, small protein particles and small fat particles, and is easier to digest and absorb by human bodies; meanwhile, the goat milk contains rich adenosine triphosphate, can promote the decomposition and transformation of lactose, does not produce gastrointestinal symptoms such as abdominal distension, diarrhea and the like when being drunk, and is suitable for children with diarrhea.
The nutritional goat milk powder suitable for diarrhea children is suitable for diarrhea children, and is used for assisting in treating and relieving diarrhea symptoms; the preparation method is simple, the raw materials are wide in source and low in cost, and the goat milk powder is suitable for industrial production and is used for preparing the nutritional goat milk powder suitable for children with diarrhea.
Detailed Description
The present invention is further illustrated by the following specific examples, which are to be construed as merely illustrative, and not limitative of the remainder of the disclosure.
Examples 1-6 preparation of nutritional goat milk powder suitable for diarrhea children
Examples 1-6 a nutritional goat milk powder suitable for diarrhea children was prepared, comprising the following steps in sequence:
preparing composite components
The corresponding components were prepared in the amounts indicated in Table 1 as corresponding combinations in examples 1 to 6:
table 1 examples 1-6 compounding ingredient tables
Figure BDA0002859123320000051
Figure BDA0002859123320000061
In table 1, the proportional relation 1 is the weight ratio among vitamin a, vitamin D, vitamin E, vitamin C and vitamin B in the multivitamin;
the proportional relation 2 is the weight ratio among magnesium sulfate, ferrous sulfate and zinc sulfate in the composite mineral substance;
the proportion relation 3 is the weight ratio of the Chinese yam powder, the tuckahoe powder, the japonica rice powder, the millet powder, the carrot powder and the white hyacinth bean powder in the nutrition supplementing powder;
the proportional relation 4 is the weight ratio of the lactobacillus paracasei N1115 powder, the bifidobacterium animalis i797 powder, the streptococcus thermophilus JMCC0024 powder and the lactobacillus rhamnosus X253 powder in the composite powder. The fungus powder is a product of the company.
The Bifidobacterium animalis subsp lactis i797 used in the invention is preserved in the China general microbiological culture collection center (the national patent office appoints the patent microbiological collection center) of China microbiological culture collection management committee general microbiological collection center No. 3 of Beijing market Shangyang Beijing province Beijing Suzuo No.1, 8 and 20 days in 2019, and the preservation numbers are as follows: CGMCC No. 18403;
lactobacillus rhamnosus x253(Lactobacillus rhamnosus x253) has been deposited in the general microbiological culture collection center of the china microbiological culture collection administration (national patent office assigned patent microbiological collection center) of north west way No.1 hospital No. 3, north township, sunny region, 2019, with the deposition numbers: CGMCC No.18404, which has been disclosed in the Chinese invention patent with patent number 202010258772.0;
although the present invention uses the above-mentioned strain, but is not limited thereto, it will be understood by those skilled in the art that all strains of the same species having the same properties can achieve the technical effects of the present invention.
(II) preparing nutritious goat milk powder
The raw materials in examples 1-6 were weighed according to table 2, the specific process parameters are shown in table 3, and the preparation was carried out according to the following steps:
firstly, taking goat milk, adding compound bacteria powder and nutrition supplementing powder with corresponding dosage, dissolving, and fermenting to obtain a mixed material I;
dissolving an application amount of choline chloride, composite mineral substances and calcium carbonate into water to obtain a mixed material II;
secondly, uniformly mixing the whey protein powder, the phospholipid, the mixture I and the mixture II in the application amount, homogenizing, spray-drying, cooling, adding the compound vitamin and the compound bacteria powder in the corresponding amount, and uniformly mixing by a dry method to obtain the nutritional goat milk powder (correspondingly marked as M1-M6) suitable for the diarrhea children.
The goat milk is standardized, subjected to impurity separation, pasteurized and homogenized, and the obtained nutritional goat milk powder suitable for diarrhea children is suitable for diarrhea children, and is used for adjuvant treatment and diarrhea symptom relief.
Table 2 examples 1-6 table of raw materials of nutritious goat milk powder
Figure BDA0002859123320000071
Figure BDA0002859123320000081
Table 3 table of process parameters for examples 1-6
Figure BDA0002859123320000082
Example 7 Effect of nutritional goat milk powder suitable for diarrhea Children on diarrhea model mice
After a diarrhea model is successfully constructed by taking 1 month old C57BL/6 mice and adopting a method of continuously feeding salmonella for 3 days by 0.3 ml/mouse, 21 mice with diarrhea symptoms are selected, half of the mice are female and male, the mice are randomly divided into 7 groups, each group comprises 3 mice,
the contrast group is perfused with 0.2mL of purified water every morning;
experimental group MX1-MX6 stomach-drenching 0.2mL each day of the nutritional goat milk powder M1-M6 prepared in examples 1-6 suitable for diarrhea children (brewing manner: 1g milk powder dissolved in 10mL purified water, 50 deg.C warm water); the experiment lasts for 5 days, the diarrhea condition of the mice is observed every day, the stool dilution rate is calculated (the result is shown in table 4), the feces of the mice are collected in a metabolism cage, and the content of lactobacillus and bifidobacterium in the feces of each group of mice is measured (the result is shown in table 5);
wherein, the calculation formula of the rare excrement rate is as follows:
the stool dilution rate is the number of stools discharged/total stool discharge in a certain period
TABLE 4 stool dilution Rate statistics
Group of 1 day 2 days 3 days 4 days 5 days
Control group 87.2％ 89.3％ 77.6％ 65.5％ 45.1％
MX1 63.2％ 33.8％ 0 0 0
MX2 60.2％ 34.5％ 12.1％ 0 0
MX3 60.4％ 32.1％ 0 0 0
MX4 60.5％ 35.4％ 5.1％ 0 0
MX5 66.7％ 33.3％ 0 0 0
MX6 63.5％ 36.7％ 6.4％ 0 0
And (3) observation and statistical result display: although diarrhea is slightly relieved after 3 days, the mice in the control group still have continuous diarrhea, defecation is performed for many times every day, water-like feces are formed at the beginning, and the feces are changed into particles after 5 days; in the mice of the experimental group, diarrhea stops after 1 day, the defecation frequency is reduced, and the defecation liquid is thick; after 2 days, no diarrhea exists, and the excrement is granular; after 3 days, the normal state is recovered. The experiments show that the mice in the control group can be self-healed slowly, and the nutritional goat milk powder suitable for diarrhea children has an obvious effect of relieving diarrhea symptoms of diarrhea model mice.
Due to the difficulty in collecting water samples and extracting nucleic acid of mice during diarrhea, except salmonella, lactobacillus and bifidobacterium are hardly detected in excrement;
from day 7 after the experiment, after the mice had healed and formed their stools, the stools were taken for the determination of lactic acid bacteria and bifidobacteria, and the results are shown in table 5:
TABLE 5 mean probiotic content after self-healing of mice
Group of Lactic acid bacteria content (Lg CFU/g) Bifidobacterium content (Lg CFU/g)
Control group 6.19 5.22
MX1 8.79 6.76
MX2 8.32 6.74
MX3 8.22 6.27
MX4 8.43 6.35
MX5 8.92 6.83
MX6 7.56 6.14
As can be seen from the table 5, the numbers of the lactic acid bacteria and the bifidobacteria in the experimental group are higher than those in the control group, which shows that the nutritional goat milk powder suitable for the children with diarrhea can inhibit the growth of pathogenic bacteria, assist in curing the diarrhea, promote the colonization of intestinal probiotics, regulate the intestinal microenvironment steady state, and increase the contents of the two probiotics to improve the diarrhea symptoms.
It should be noted that the above-mentioned embodiments are only preferred embodiments of the present invention, and are not intended to limit the present invention in other forms, and any person skilled in the art may use the above-mentioned technical content as a teaching to make changes or modifications to the equivalent embodiments with equivalent changes, but all those simple changes, equivalent changes and modifications made to the above-mentioned embodiments without departing from the technical spirit of the present invention, and still all those embodiments are within the scope of the present invention as claimed in the claims.

Claims (9)

1. The nutritional goat milk powder suitable for diarrhea children is characterized in that raw materials for preparing active ingredients of the nutritional goat milk powder comprise the following components in parts by weight:
350 parts of goat milk, 50-70 parts of whey protein powder, 0.6-0.9 part of phospholipid, 0.6-0.9 part of calcium carbonate, 0.17-0.25 part of choline chloride, 0.3-0.4 part of compound vitamin, 0.2-0.25 part of compound mineral, 7.21-8.7 parts of nutrition supplementing powder, 2-3 parts of compound bacteria powder and 2-3 parts of water.
2. The nutritional goat milk powder suitable for children with diarrhea as claimed in claim 1, wherein the vitamin complex is formed by mixing vitamin A, vitamin D, vitamin E, vitamin C and vitamin B in a weight ratio of 5-6:42-43:8:0.01: 45.
3. The nutritional goat milk powder suitable for children with diarrhea according to claim 1 or 2, wherein the compound mineral is prepared by mixing magnesium sulfate, ferrous sulfate and zinc sulfate in a weight ratio of 4-6:1: 1.
4. The nutritional goat milk powder suitable for children with diarrhea according to claim 1 or 2, wherein the nutritional supplement powder is prepared by mixing rhizoma dioscoreae powder, poria cocos powder, japonica rice powder, millet powder, carrot powder and white hyacinth bean powder in a weight ratio of 3-5:1:1-2:5:3: 2.
5. The nutritional goat milk powder suitable for children with diarrhea according to claim 1 or 2, wherein the compound bacteria powder is active freeze-dried bacteria powder and is prepared by mixing four probiotic bacteria powder, namely lactobacillus paracasei N1115 powder, bifidobacterium animalis powder, streptococcus thermophilus powder and lactobacillus rhamnosus powder in a weight ratio of 2-3:1:1-2: 1.
6. The nutritious goat milk powder suitable for children with diarrhea as claimed in claim 5, wherein the total number of colonies of four probiotics in the composite bacterial powder is 1 x 1012-1.3×1012CFU/g。
7. A process for the preparation of a nutritional goat milk powder suitable for diarrhea children as claimed in any one of claims 1 to 6, which comprises the following steps in sequence:
firstly, 50-70% of goat milk is addedMixing the bacteria powder and the nutrition supplementing powder, dissolving, and fermenting to obtain mixed material
Figure 952404DEST_PATH_IMAGE001
；
Dissolving choline chloride, compound mineral substance and calcium carbonate in water to obtain mixed material
Figure 621283DEST_PATH_IMAGE002
；
② mixing the whey protein powder, the phospholipid and the mixture
Figure 676964DEST_PATH_IMAGE001
Mixing the materials
Figure 493610DEST_PATH_IMAGE002
And (3) uniformly mixing, homogenizing, spray-drying, cooling, adding the compound vitamin and the rest of the compound bacteria powder, and uniformly mixing by a dry method to obtain the nutritional goat milk powder suitable for children with diarrhea.
8. The method for preparing nutritious goat milk powder suitable for children with diarrhea as claimed in claim 7,
in the step I, the fermentation temperature is 37-43 ℃ and the fermentation time is 4-5 h;
in the second step, the pressure of the homogenization is 190-210 bar;
the spray pressure of the spray drying is 240bar minus 180 DEG plus, the air inlet temperature is 170 DEG plus 150 DEG plus, the air exhaust temperature is 85-90 ℃, and the pressure in the drying chamber is-110-90 Pa.
9. Use of the nutritional goat milk powder suitable for children with diarrhea as claimed in any one of claims 1-6, wherein the nutritional goat milk powder suitable for children with diarrhea is suitable for children with diarrhea for adjuvant treatment and alleviation of diarrhea symptoms.
CN202011557257.9A 2020-12-25 2020-12-25 Nutritional goat milk powder suitable for diarrhea children and preparation method and application thereof Pending CN112640958A (en)

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CN108850397A (en) * 2018-06-15 2018-11-23 广东燕岭生命科技股份有限公司 A kind of probiotic gel candy and preparation method thereof of only diarrhea
CN109287756A (en) * 2018-10-12 2019-02-01 江门市新会区古井源丰资产管理有限公司 A kind of formula milk
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CN109673750A (en) * 2019-02-19 2019-04-26 南昌萃诗贸易有限公司 A kind of baby milk powder and preparation method thereof for treating rotavirus diarrhea
CN110999969A (en) * 2019-12-19 2020-04-14 伊犁那拉乳业集团有限公司 Preparation method and composition of probiotic formula goat milk powder capable of regulating intestines and stomach
CN111543640A (en) * 2020-05-08 2020-08-18 石家庄君乐宝乳业有限公司 Application of bifidobacterium animalis subsp lactis i797 for improving infantile diarrhea and dyspepsia
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102283387A (en) * 2011-09-07 2011-12-21 西安力邦临床营养有限公司 Formulated food for treating diarrhea
CN104996576A (en) * 2015-08-28 2015-10-28 海普诺凯营养品有限公司 Goat milk powder for infant and preparation method thereof
CN108142928A (en) * 2017-12-25 2018-06-12 北京数果科技有限公司 For the compound probiotic composition of intestinal canal regulating and its application
CN108850397A (en) * 2018-06-15 2018-11-23 广东燕岭生命科技股份有限公司 A kind of probiotic gel candy and preparation method thereof of only diarrhea
CN109287756A (en) * 2018-10-12 2019-02-01 江门市新会区古井源丰资产管理有限公司 A kind of formula milk
CN109527096A (en) * 2018-12-28 2019-03-29 陕西科技大学 A kind of probiotic formulation goat milk powder and preparation method thereof
CN109673750A (en) * 2019-02-19 2019-04-26 南昌萃诗贸易有限公司 A kind of baby milk powder and preparation method thereof for treating rotavirus diarrhea
CN110999969A (en) * 2019-12-19 2020-04-14 伊犁那拉乳业集团有限公司 Preparation method and composition of probiotic formula goat milk powder capable of regulating intestines and stomach
CN111543640A (en) * 2020-05-08 2020-08-18 石家庄君乐宝乳业有限公司 Application of bifidobacterium animalis subsp lactis i797 for improving infantile diarrhea and dyspepsia
CN111820285A (en) * 2020-07-09 2020-10-27 石家庄君乐宝乳业有限公司 Milk powder suitable for flatulence infants and preparation method thereof

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