CN112618679A - Xiajujin Jiekang oral liquid and preparation method thereof - Google Patents
Xiajujin Jiekang oral liquid and preparation method thereof Download PDFInfo
- Publication number
- CN112618679A CN112618679A CN202011553326.9A CN202011553326A CN112618679A CN 112618679 A CN112618679 A CN 112618679A CN 202011553326 A CN202011553326 A CN 202011553326A CN 112618679 A CN112618679 A CN 112618679A
- Authority
- CN
- China
- Prior art keywords
- parts
- rhizome
- jiekang
- oral liquid
- extracting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000007788 liquid Substances 0.000 title claims abstract description 21
- 238000002360 preparation method Methods 0.000 title claims abstract description 14
- 239000000463 material Substances 0.000 claims abstract description 22
- 244000197580 Poria cocos Species 0.000 claims abstract description 19
- 235000008599 Poria cocos Nutrition 0.000 claims abstract description 19
- 241000132012 Atractylodes Species 0.000 claims abstract description 18
- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 claims abstract description 18
- 241000222336 Ganoderma Species 0.000 claims abstract description 17
- 241001522129 Pinellia Species 0.000 claims abstract description 17
- 240000009022 Smilax rotundifolia Species 0.000 claims abstract description 15
- 235000003205 Smilax rotundifolia Nutrition 0.000 claims abstract description 15
- 240000009138 Curcuma zedoaria Species 0.000 claims abstract description 14
- 235000003405 Curcuma zedoaria Nutrition 0.000 claims abstract description 14
- 241000112528 Ligusticum striatum Species 0.000 claims abstract description 14
- 244000179560 Prunella vulgaris Species 0.000 claims abstract description 14
- 239000001812 curcuma zedoaria berg. rosc. Substances 0.000 claims abstract description 14
- 235000008113 selfheal Nutrition 0.000 claims abstract description 14
- 235000019509 white turmeric Nutrition 0.000 claims abstract description 14
- 235000006533 astragalus Nutrition 0.000 claims abstract description 12
- 238000000855 fermentation Methods 0.000 claims abstract description 12
- 230000004151 fermentation Effects 0.000 claims abstract description 12
- 241000045403 Astragalus propinquus Species 0.000 claims abstract description 11
- 238000000034 method Methods 0.000 claims abstract description 11
- 238000002156 mixing Methods 0.000 claims abstract description 11
- 238000003809 water extraction Methods 0.000 claims abstract description 11
- 235000014375 Curcuma Nutrition 0.000 claims abstract description 8
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 claims abstract description 8
- 235000016993 Agrimonia Nutrition 0.000 claims abstract description 6
- 244000307697 Agrimonia eupatoria Species 0.000 claims abstract description 6
- 241000233866 Fungi Species 0.000 claims abstract description 6
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims abstract description 6
- 238000006243 chemical reaction Methods 0.000 claims abstract description 6
- 238000011049 filling Methods 0.000 claims abstract description 6
- 239000011521 glass Substances 0.000 claims abstract description 6
- 230000000415 inactivating effect Effects 0.000 claims abstract description 6
- 239000011344 liquid material Substances 0.000 claims abstract description 6
- 238000004519 manufacturing process Methods 0.000 claims abstract description 6
- 238000003756 stirring Methods 0.000 claims abstract description 6
- 238000005406 washing Methods 0.000 claims abstract description 6
- 230000008569 process Effects 0.000 claims abstract description 5
- 241000245665 Taraxacum Species 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 13
- 244000163122 Curcuma domestica Species 0.000 claims description 10
- 238000009835 boiling Methods 0.000 claims description 10
- 239000012153 distilled water Substances 0.000 claims description 10
- 238000001914 filtration Methods 0.000 claims description 10
- 244000236521 Bupleurum rotundifolium Species 0.000 claims description 6
- 235000015221 Bupleurum rotundifolium Nutrition 0.000 claims description 6
- 241000675108 Citrus tangerina Species 0.000 claims description 6
- 241000212322 Levisticum officinale Species 0.000 claims description 6
- 244000148137 Patrinia villosa Species 0.000 claims description 6
- 235000019109 Patrinia villosa Nutrition 0.000 claims description 6
- 241000329195 Sparganium erectum Species 0.000 claims description 6
- 229940107666 astragalus root Drugs 0.000 claims description 6
- 235000003373 curcuma longa Nutrition 0.000 claims description 6
- 239000001645 levisticum officinale Substances 0.000 claims description 6
- 235000001188 Peltandra virginica Nutrition 0.000 claims description 5
- 239000000706 filtrate Substances 0.000 claims description 5
- 244000304337 Cuminum cyminum Species 0.000 claims description 3
- 235000007129 Cuminum cyminum Nutrition 0.000 claims description 3
- 235000003392 Curcuma domestica Nutrition 0.000 claims description 3
- 239000001215 curcuma longa l. root Substances 0.000 claims description 3
- 235000013976 turmeric Nutrition 0.000 claims description 3
- 244000011358 Patrinia scabiosaefolia Species 0.000 claims description 2
- 235000009267 Patrinia scabiosaefolia Nutrition 0.000 claims description 2
- 239000012530 fluid Substances 0.000 claims description 2
- 239000006228 supernatant Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 36
- 239000003814 drug Substances 0.000 abstract description 11
- 230000001737 promoting effect Effects 0.000 abstract description 11
- 230000008961 swelling Effects 0.000 abstract description 8
- 208000009453 Thyroid Nodule Diseases 0.000 abstract description 7
- 238000005728 strengthening Methods 0.000 abstract description 5
- 206010062717 Increased upper airway secretion Diseases 0.000 abstract description 4
- 239000000203 mixture Substances 0.000 abstract description 4
- 208000026435 phlegm Diseases 0.000 abstract description 4
- 206010028980 Neoplasm Diseases 0.000 abstract description 3
- 208000004880 Polyuria Diseases 0.000 abstract description 3
- 230000035619 diuresis Effects 0.000 abstract description 3
- 210000002966 serum Anatomy 0.000 abstract description 3
- 206010027476 Metastases Diseases 0.000 abstract description 2
- 108010034949 Thyroglobulin Proteins 0.000 abstract description 2
- 201000011510 cancer Diseases 0.000 abstract description 2
- 230000009401 metastasis Effects 0.000 abstract description 2
- 229960002175 thyroglobulin Drugs 0.000 abstract description 2
- 244000164480 Curcuma aromatica Species 0.000 abstract 1
- 240000001949 Taraxacum officinale Species 0.000 abstract 1
- 102000009843 Thyroglobulin Human genes 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 description 15
- 210000004185 liver Anatomy 0.000 description 14
- 210000004369 blood Anatomy 0.000 description 9
- 239000008280 blood Substances 0.000 description 9
- 230000017531 blood circulation Effects 0.000 description 7
- 241000202726 Bupleurum Species 0.000 description 6
- 230000000968 intestinal effect Effects 0.000 description 6
- 210000002216 heart Anatomy 0.000 description 5
- 210000000952 spleen Anatomy 0.000 description 5
- 208000004998 Abdominal Pain Diseases 0.000 description 4
- 206010007247 Carbuncle Diseases 0.000 description 4
- KYWSCMDFVARMPN-LCSVLAELSA-N Saikosaponin D Chemical compound O([C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@]([C@H]3[C@]([C@@H]4[C@@]([C@@]5(C[C@@H](O)[C@]67CO[C@]5([C@@H]6CC(C)(C)CC7)C=C4)C)(C)CC3)(C)CC2)(C)CO)O[C@@H]([C@@H]1O)C)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O KYWSCMDFVARMPN-LCSVLAELSA-N 0.000 description 4
- 210000000232 gallbladder Anatomy 0.000 description 4
- 230000005764 inhibitory process Effects 0.000 description 4
- 210000004072 lung Anatomy 0.000 description 4
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 4
- 229930192014 saikosaponin Natural products 0.000 description 4
- 229930182490 saponin Natural products 0.000 description 4
- 150000007949 saponins Chemical class 0.000 description 4
- 208000024770 Thyroid neoplasm Diseases 0.000 description 3
- 230000003213 activating effect Effects 0.000 description 3
- 210000000038 chest Anatomy 0.000 description 3
- 230000004087 circulation Effects 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 230000002496 gastric effect Effects 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 210000005229 liver cell Anatomy 0.000 description 3
- 230000002829 reductive effect Effects 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 210000001685 thyroid gland Anatomy 0.000 description 3
- 238000005303 weighing Methods 0.000 description 3
- 201000000736 Amenorrhea Diseases 0.000 description 2
- 206010001928 Amenorrhoea Diseases 0.000 description 2
- 206010023126 Jaundice Diseases 0.000 description 2
- PUPKKEQDLNREIM-UHFFFAOYSA-N Kaempferitin Natural products OC1C(O)C(O)C(C)OC1OC1=CC(O)=C2C(=O)C(OC3C(C(O)C(O)C(C)O3)O)=C(C=3C=CC(O)=CC=3)OC2=C1 PUPKKEQDLNREIM-UHFFFAOYSA-N 0.000 description 2
- 208000024799 Thyroid disease Diseases 0.000 description 2
- 208000025865 Ulcer Diseases 0.000 description 2
- SOSLMHZOJATCCP-PADPQNGGSA-N afzelin Natural products O([C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](C)O1)C1=C(c2ccc(O)cc2)Oc2c(c(O)cc(O)c2)C1=O SOSLMHZOJATCCP-PADPQNGGSA-N 0.000 description 2
- 231100000540 amenorrhea Toxicity 0.000 description 2
- 235000019658 bitter taste Nutrition 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- ZMGSKTZDVIZXJS-UHFFFAOYSA-N kaempferitrin Natural products CC1OC(OC2C(Oc3cc(OC4OC(C)C(O)C(O)C4O)cc(O)c3C2=O)c5ccc(O)cc5)C(O)C(O)C1O ZMGSKTZDVIZXJS-UHFFFAOYSA-N 0.000 description 2
- PUPKKEQDLNREIM-QNSQPKOQSA-N kaempferol 3,7-di-O-alpha-L-rhamnoside Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1OC1=CC(O)=C2C(=O)C(O[C@H]3[C@@H]([C@H](O)[C@@H](O)[C@H](C)O3)O)=C(C=3C=CC(O)=CC=3)OC2=C1 PUPKKEQDLNREIM-QNSQPKOQSA-N 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 235000019633 pungent taste Nutrition 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 235000019640 taste Nutrition 0.000 description 2
- 230000008736 traumatic injury Effects 0.000 description 2
- 231100000397 ulcer Toxicity 0.000 description 2
- 239000000341 volatile oil Substances 0.000 description 2
- 102100033639 Acetylcholinesterase Human genes 0.000 description 1
- 108010022752 Acetylcholinesterase Proteins 0.000 description 1
- 241000208838 Asteraceae Species 0.000 description 1
- 241001061264 Astragalus Species 0.000 description 1
- 208000008035 Back Pain Diseases 0.000 description 1
- 206010006002 Bone pain Diseases 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 206010006272 Breast mass Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 206010006312 Breast swelling Diseases 0.000 description 1
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 1
- 206010010726 Conjunctival oedema Diseases 0.000 description 1
- 206010012374 Depressed mood Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 208000035240 Disease Resistance Diseases 0.000 description 1
- 206010013954 Dysphoria Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 240000008397 Ganoderma lucidum Species 0.000 description 1
- 235000001637 Ganoderma lucidum Nutrition 0.000 description 1
- 229920002527 Glycogen Polymers 0.000 description 1
- 244000303040 Glycyrrhiza glabra Species 0.000 description 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 206010019909 Hernia Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010022714 Intestinal ulcer Diseases 0.000 description 1
- 206010067125 Liver injury Diseases 0.000 description 1
- 208000008930 Low Back Pain Diseases 0.000 description 1
- 208000037093 Menstruation Disturbances Diseases 0.000 description 1
- 206010027339 Menstruation irregular Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 206010033425 Pain in extremity Diseases 0.000 description 1
- 102000057297 Pepsin A Human genes 0.000 description 1
- 108090000284 Pepsin A Proteins 0.000 description 1
- 208000025747 Rheumatic disease Diseases 0.000 description 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 208000033809 Suppuration Diseases 0.000 description 1
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
- 102100033504 Thyroglobulin Human genes 0.000 description 1
- 102000003929 Transaminases Human genes 0.000 description 1
- 108090000340 Transaminases Proteins 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 208000036029 Uterine contractions during pregnancy Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 208000019790 abdominal distention Diseases 0.000 description 1
- 208000020560 abdominal swelling Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 description 1
- 229960004373 acetylcholine Drugs 0.000 description 1
- 229940022698 acetylcholinesterase Drugs 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000003042 antagnostic effect Effects 0.000 description 1
- 230000001754 anti-pyretic effect Effects 0.000 description 1
- 239000002221 antipyretic Substances 0.000 description 1
- 230000005784 autoimmunity Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000000941 bile Anatomy 0.000 description 1
- 239000003833 bile salt Substances 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 208000019425 cirrhosis of liver Diseases 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 208000010515 dystocia Diseases 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002212 flavone derivatives Chemical group 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 210000002683 foot Anatomy 0.000 description 1
- 210000001156 gastric mucosa Anatomy 0.000 description 1
- 229940096919 glycogen Drugs 0.000 description 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000011132 hemopoiesis Effects 0.000 description 1
- 208000014617 hemorrhoid Diseases 0.000 description 1
- 231100000753 hepatic injury Toxicity 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 235000011477 liquorice Nutrition 0.000 description 1
- 201000003453 lung abscess Diseases 0.000 description 1
- 201000007227 lymph node tuberculosis Diseases 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 201000004792 malaria Diseases 0.000 description 1
- 208000004396 mastitis Diseases 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 208000015122 neurodegenerative disease Diseases 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 230000024121 nodulation Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 230000000552 rheumatic effect Effects 0.000 description 1
- 229920002477 rna polymer Polymers 0.000 description 1
- BJSMUQGQPSXQSW-BWQQITLZSA-N saikosapogenin a Chemical compound OC[C@@](C)([C@@H]1CC[C@@]2(C)[C@@H]3C[C@@H]4O)[C@@H](O)CC[C@]1(C)[C@H]2C=C[C@@]31OC[C@@]42CCC(C)(C)C[C@H]21 BJSMUQGQPSXQSW-BWQQITLZSA-N 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 230000009758 senescence Effects 0.000 description 1
- 230000002048 spasmolytic effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229960004793 sucrose Drugs 0.000 description 1
- 230000000152 swallowing effect Effects 0.000 description 1
- 210000004233 talus Anatomy 0.000 description 1
- 201000002510 thyroid cancer Diseases 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 229940126672 traditional medicines Drugs 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 230000008728 vascular permeability Effects 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/536—Prunella or Brunella (selfheal)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/84—Valerianaceae (Valerian family), e.g. valerian
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K36/8888—Pinellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/90—Smilacaceae (Catbrier family), e.g. greenbrier or sarsaparilla
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/902—Sparganiaceae (Bur-reed family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Mycology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a Xiajujin Jiekang oral liquid and a preparation method thereof, wherein the preparation method comprises the following steps: s1, extracting 5 kinds of poria cocos, pericarpium citri reticulatae viride, bighead atractylodes rhizome, astragalus membranaceus and lucid ganoderma slices together by a conventional water extraction method twice, fermenting the extracting solution for 24 hours by using edible yeast, and then inactivating fungi at high temperature to obtain fermentation liquor; s2, washing 11 kinds of materials including ligusticum wallichii, pinellia ternate, radix bupleuri, radix curcumae, dandelion, selfheal spike, rhizoma sparganii, curcuma zedoary, herba patriniae, bock greenbrier rhizome and hairyvein agrimonia herb, and extracting twice according to a water extraction process to obtain an extracting solution; s3, mixing the fermentation liquor and the extracting solution together, and uniformly stirring in a reaction kettle for 35 minutes; s4, filling the liquid material into a 50ML glass bottle by using a professional production line to obtain the xiapujin jiekang oral liquid. Through reasonable compatibility of the medicinal materials, the traditional Chinese medicine composition has the effects of detoxifying, relieving swelling, resolving masses, dissipating phlegm, tonifying qi, nourishing yin, promoting diuresis, eliminating turbidity, strengthening body resistance and eliminating evil, reducing thyroid nodules, reducing serum thyroglobulin level, preventing recurrence and metastasis of cancer, and improving the life quality of patients.
Description
Technical Field
The invention relates to the technical field of thyroid nodule medicines, and particularly relates to a Xia pu jin nodokang oral liquid and a preparation method thereof.
Background
Thyroid nodule is a lump in the thyroid gland, can move up and down with the thyroid gland along with swallowing action, is a common clinical disease and can be caused by various causes. Clinically, various thyroid diseases such as thyroid degenerative disease, inflammation, autoimmunity, neoplasms and the like can be expressed as nodules. Thyroid nodules can be single-shot or multiple-shot, and multiple nodules have higher morbidity than single nodules, but the incidence rate of thyroid cancer of single nodules is higher.
Thyroid diseases occur in people of various ages, wherein middle-aged women are more, according to the prior art, the curative effect of treating thyroid nodules is generally not ideal, the curative effect contains large uncertain factors, and meanwhile, the medicines taken for a long time are easy to cause large side effects, so that the medicines capable of effectively treating the thyroid nodules are urgently needed to replace the traditional medicines, and the effects of treatment and prevention are achieved while the side effects are reduced.
Disclosure of Invention
The invention mainly aims to provide a Xiajujin Jikang oral liquid and a preparation method thereof, aiming at reducing the side effect of the medicine, preventing and treating the diseases simultaneously and achieving the treatment effect.
In order to achieve the purpose, the invention provides a Xia pu jin jiekang oral liquid which comprises the following medicinal materials: 1-1.5 parts of bighead atractylodes rhizome, 1-1.2 parts of ligusticum wallichii, 1-1.7 parts of lucid ganoderma slices, 1-1.3 parts of pinellia ternate, 1.2-1.5 parts of radix bupleuri, 1-1.2 parts of radix curcumae, 1-1.5 parts of pericarpium citri reticulatae viride, 0.9-1.3 parts of dandelion, 1-1.5 parts of selfheal spike, 1.5-1.7 parts of poria cocos, 1.8-2 parts of rhizoma smilacis glabrae, 2-2.3 parts of astragalus membranaceus, 0.8-1 part of rhizoma sparganii, 1-1.1 parts of curcuma zedoary and 1.5-2 parts of patrinia scabiosaefolia.
The preparation method comprises the following steps:
s1, extracting 5 kinds of poria cocos, pericarpium citri reticulatae viride, bighead atractylodes rhizome, astragalus membranaceus and lucid ganoderma slices together by a conventional water extraction method twice, fermenting the extracting solution for 24 hours by using edible yeast, and then inactivating fungi at high temperature to obtain fermentation liquor;
s2, washing 11 kinds of materials including ligusticum wallichii, pinellia ternate, radix bupleuri, radix curcumae, dandelion, selfheal spike, rhizoma sparganii, curcuma zedoary, herba patriniae, bock greenbrier rhizome and hairyvein agrimonia herb, and extracting twice according to a water extraction process to obtain an extracting solution;
s3, mixing the fermentation liquor and the extracting solution together, and uniformly stirring in a reaction kettle for 35 minutes;
s4, filling the liquid material into a 50ML glass bottle by using a professional production line to obtain the xiapujin jiekang oral liquid.
Optionally, the following medicinal materials are included: 1.5 parts of bighead atractylodes rhizome, 1 part of ligusticum wallichii, 1.5 parts of lucid ganoderma slices, 1 part of pinellia ternate, 1.5 parts of radix bupleuri, 1 part of radix curcumae, 1 part of pericarpium citri reticulatae viride, 1 part of dandelion, 1.5 parts of selfheal spike, 1.5 parts of poria cocos, 2 parts of bock greenbrier rhizome, 2 parts of astragalus membranaceus, 1 part of rhizoma sparganii, 1 part of curcuma zedoary and 2 parts of herba patriniae.
Optionally, the following medicinal materials are included: 1 part of largehead atractylodes rhizome, 1.2 parts of szechuan lovage rhizome, 1.7 parts of lucid ganoderma slices, 1.3 parts of pinellia tuber, 1.2 parts of Chinese thorowax root, 1.1 parts of turmeric root tuber, 1.2 parts of green tangerine orange peel, 0.9 part of dandelion, 1.4 parts of selfheal spike, 1.7 parts of tuckahoe, 1.8 parts of bock greenbrier rhizome, 2.3 parts of astragalus root, 0.8 part of common burreed rhizome, 1.1 parts of zedoary and 2 parts of dahurian patrinia herb.
Optionally, the following medicinal materials are included: 1.3 parts of largehead atractylodes rhizome, 1.1 parts of szechuan lovage rhizome, 1 part of glossy ganoderma slice, 1 part of pinellia tuber, 1.25 parts of Chinese thorowax root, 1.13 parts of turmeric root-tuber, 1.3 parts of green tangerine peel, 1.3 parts of dandelion, 1 part of summer cumin, 1.6 parts of poria cocos, 2 parts of bock greenbrier rhizome, 2 parts of astragalus root, 0.9 part of common burreed rhizome, 1 part of zedoary and 1.5 parts of dahurian patrinia herb.
Optionally, the water extraction process in S2 is: mixing 11 medicinal materials with distilled water at a mass ratio of 1:17, decocting until boiling, keeping boiling for 1-5 min, extracting at 42 deg.C for 1.5 hr to obtain a primary extractive solution, adding distilled water into the primary extractive solution at a mass ratio of 1:10, and extracting at 42 deg.C for 1 hr to obtain a secondary extractive solution.
Optionally, filtering the secondary extractive solution, concentrating to obtain fluid extract, refrigerating for 18 hr, collecting supernatant, filtering, and collecting mixed filtrate.
The white atractylodes rhizome has the functions of regulating gastrointestinal movement, promoting the growth of liver cells and protecting the liver, and has the functions of enhancing hematopoiesis and enhancing the immunity of organisms, has a certain inhibition effect on intestinal ulcer, and has the effects of inhibiting uterine contraction, resisting oxidation and delaying senescence.
The ligusticum wallichii is a traditional Chinese medicine with mild properties and pungent and bitter taste, enters liver and gallbladder channels, has important effects of promoting qi circulation, relieving depression, dispelling wind and removing dampness, and can be directly taken when people feel uncomfortable due to liver qi, so that symptoms can be improved as soon as possible. In addition, the traditional Chinese medicine composition can be clinically used for treating human rheumatic bone pain, and can relieve symptoms of arthrocele and pain of people as soon as possible. The ligusticum wallichii is also a traditional Chinese medicine material capable of activating blood circulation to stop pain, can be used for treating various common diseases such as female amenorrhea, dystocia, irregular menstruation and the like at ordinary times, can accelerate qi and blood circulation, and can enable the adverse symptoms of the female to disappear as soon as possible. In addition, when people in life have traumatic swelling pain and abdominal swelling pain, the ligusticum wallichii can be used for treating, and the treatment effect is particularly obvious.
The ganoderma lucidum tablet is a common traditional Chinese medicine and also is a health-care medicinal food. It has effects of nourishing heart, tranquilizing mind, invigorating lung, invigorating qi, regulating qi-flowing, removing blood stasis, nourishing liver, invigorating spleen, and invigorating kidney.
Ban Xia has the actions of harmonizing stomach and stopping vomiting, drying dampness and eliminating phlegm, dissipating nodulation and relieving swelling.
The bupleurum has obvious central antipyretic and cooling effects, and the effective components of the bupleurum are related to the contained saponin and the volatile oil. The bupleurum saponin and the volatile oil thereof, the crude saikosaponin, the saikosapogenin A, the kaempferitrin and the like have obvious inhibition effect on experimental foot swelling of mice and have obvious inhibition effect on vascular permeability. The bupleurum preparation has obvious antagonistic action on animal experimental liver injury, can reduce degeneration and necrosis of liver cells, recover or approximate to normal the content of most liver glycogen and ribonucleic acid accumulated in the liver cells, and obviously reduce the activity of serum transaminase; and can inhibit fibroplasia of injured liver, promote fiber absorption, and reduce liver cirrhosis. The effect of the mixture of liquorice and firewood is the best. Radix bupleuri can increase total bile output and bile salt content of dog. The effective component is flavone. The crude saikosaponin has obvious effect of inhibiting gastric secretion, so that the pepsin activity is reduced, and the ulcer coefficient is reduced. When the dose is increased from 10mg/kg to 50-100 mg/kg, the ulcer tends to worsen. This may be caused by saponin irritation of the gastric mucosa. The saikosaponin can excite isolated intestinal canal and improve the tension of intestinal muscle when the concentration of saikosaponin is small; when the concentration is increased, the intestinal canal contraction caused by acetylcholine is enhanced due to the inhibition of acetylcholinesterase in blood plasma. On the other hand, the bupleurum kaempferitrin has spasmolytic effect on isolated intestinal canal. The bupleurum extract has obvious inhibiting effect on trypsin.
The radix curcumae is pungent, slightly bitter and cold in nature, belongs to liver, heart and lung channels, has the effects of promoting qi circulation, relieving depression, activating blood circulation, relieving pain, clearing away heart-fire, cooling blood, benefiting gallbladder and removing jaundice, can be used for treating low mood, dysphoria and the like caused by liver depression, has the effects of soothing liver, relieving depression and relieving pain on stabbing pain and distending pain in chest, and also has the effects of relieving pain and activating blood circulation on chest stuffiness and pain.
Pericarpium Citri Reticulatae viride is slightly warm in nature and bitter and pungent in flavor, enters liver and gallbladder meridians, has the effects of soothing liver, breaking qi, dissipating stagnation and dissolving phlegm, and is commonly used for treating chest, hypochondrium, gastric cavity pain, hernia, dyspepsia, breast swelling, breast nodule, chronic malaria nodule, etc.
Herba Taraxaci, also called GUGUGUDING, herba Veronicae Didyma, HUANGMIAO, HUANGDIDIDING, and herba Saxifragae, which are perennial herb plants of Taraxacum of Compositae. The herba Taraxaci is prepared from chopped and dried root or leaf, is rich in vitamins and minerals, and has effects of strengthening liver and reducing cholesterol. The dandelion is sweet in taste and slightly bitter in taste, and has the effects of clearing heat and removing toxicity, promoting urination, relieving diarrhea, reducing jaundice, benefiting gallbladder and the like.
The summer-heat-clearing pill has the effects of clearing liver fire and dissipating blood stasis. Has good curative effects on conjunctival congestion, swelling and pain, headache, dizziness, hypertension, acute mastitis, breast cancer, facial distortion, oblique eyes, hemorrhoids and the like.
The tuckahoe has sweet, bland and mild flavor and is also responsible for the heart, lung, spleen and kidney. The tuckahoe has the effects and functions of excreting dampness and promoting diuresis, strengthening spleen and stomach, calming heart and soothing nerves.
The functions and effects of rhizoma Smilacis Bockii are dispelling pathogenic wind, promoting blood circulation, and removing toxic substance. It is indicated for wind-damp, lumbago, leg pain, traumatic injury, scrofula.
The astragalus contains rich nutrient substances including cane sugar, saponin, amino acid, zinc, selenium and other trace elements, and has good effects of treating respiratory system diseases and improving the disease resistance of the lung. It also has spleen strengthening effect, and can promote metabolism.
Triangular, neutral in nature; bitter and pungent taste; it enters liver and spleen meridians. Has the effects of breaking blood, promoting qi circulation, removing food retention, and relieving pain. It is used to treat abdominal pain, abdominal distention, amenorrhea, postpartum abdominal pain due to blood stasis, traumatic injury, stagnation of qi and blood, and pain in heart and abdomen. Sores and swelling are hard.
Rhizoma Curcumae has effects of promoting blood circulation and removing blood stasisMedicine for removing blood stasisSoftening and resolving hard mass, dispelling pathogenic wind and removing dampness.
Herba Patriniae is slightly cold in nature, has the effects of clearing heat and detoxicating, eliminating carbuncle and discharging pus, and promoting blood circulation and removing blood stasis and relieving pain, can be used for treating intestinal carbuncle, pulmonary abscess, carbuncle swelling and sore toxin, postpartum stasis and abdominal pain and the like, and is a preferred medicine for treating intestinal carbuncle abdominal pain.
The invention has the beneficial effects that: through reasonable compatibility of the medicinal materials, the traditional Chinese medicine composition has the effects of detoxifying, relieving swelling, resolving masses, dissipating phlegm, tonifying qi, nourishing yin, promoting diuresis, eliminating turbidity, strengthening body resistance and eliminating evil, reducing thyroid nodules, reducing serum thyroglobulin level, preventing recurrence and metastasis of cancer, and improving the life quality of patients.
Detailed Description
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs; the terminology used herein in the description of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention; the terms "comprising" and "having," and any variations thereof, in the description of the invention and in the claims, are intended to cover non-exclusive inclusions; the terms first, second and the like in the description and in the claims of the present invention are used for distinguishing between different objects and not for describing a particular order.
Reference herein to "an embodiment" means that a particular feature, structure, or characteristic described in connection with the embodiment can be included in at least one embodiment of the invention. The appearances of the phrase in various places in the specification are not necessarily all referring to the same embodiment, nor are separate or alternative embodiments mutually exclusive of other embodiments. It is explicitly and implicitly understood by one skilled in the art that the embodiments described herein can be combined with other embodiments.
Example 1
The invention relates to a Xiajujin Jiekang oral liquid, which comprises the following medicinal materials: 1.5 parts of bighead atractylodes rhizome, 1 part of ligusticum wallichii, 1.5 parts of lucid ganoderma slices, 1 part of pinellia ternate, 1.5 parts of radix bupleuri, 1 part of radix curcumae, 1 part of pericarpium citri reticulatae viride, 1 part of dandelion, 1.5 parts of selfheal spike, 1.5 parts of poria cocos, 2 parts of bock greenbrier rhizome, 2 parts of astragalus membranaceus, 1 part of rhizoma sparganii, 1 part of curcuma zedoary and 2 parts of herba patriniae.
The preparation method comprises the following steps:
s1, extracting 5 kinds of poria cocos, pericarpium citri reticulatae viride, bighead atractylodes rhizome, astragalus membranaceus and lucid ganoderma slices together by a conventional water extraction method twice, fermenting the extracting solution for 24 hours by using edible yeast, and then inactivating fungi at high temperature to obtain fermentation liquor;
s2, weighing 11 kinds of materials including ligusticum wallichii, pinellia ternate, radix bupleuri, radix curcumae, dandelion, selfheal, rhizoma sparganii, rhizoma zedoariae, herba patriniae, bock greenbrier rhizome and hairyvein agrimonia herb, washing with water, mixing with distilled water according to a mass ratio of 1:17, decocting together until boiling, keeping boiling for 5 minutes, extracting at 42 ℃ for 1.5 hours to obtain a primary extracting solution, pouring the distilled water into the primary extracting solution according to a mass ratio of 1:10, extracting at 42 ℃ for 1 hour to obtain a secondary extracting solution, filtering residues of the secondary extracting solution, concentrating the secondary extracting solution to obtain clear paste, refrigerating for 18 hours, taking supernate, filtering, and collecting mixed filtrate;
s3, mixing the fermentation liquor and the extracting solution together, and uniformly stirring in a reaction kettle for 35 minutes;
s4, filling the liquid material into a 50ML glass bottle by using a professional production line to obtain the xiapujin jiekang oral liquid.
Example 2
The invention relates to a Xiajujin Jiekang oral liquid, which comprises the following medicinal materials: 1 part of largehead atractylodes rhizome, 1.2 parts of szechuan lovage rhizome, 1.7 parts of lucid ganoderma slices, 1.3 parts of pinellia tuber, 1.2 parts of Chinese thorowax root, 1.1 parts of turmeric root tuber, 1.2 parts of green tangerine orange peel, 0.9 part of dandelion, 1.4 parts of selfheal spike, 1.7 parts of tuckahoe, 1.8 parts of bock greenbrier rhizome, 2.3 parts of astragalus root, 0.8 part of common burreed rhizome, 1.1 parts of zedoary and 2 parts of dahurian patrinia herb.
The preparation method comprises the following steps:
the preparation method comprises the following steps:
s1, extracting 5 kinds of poria cocos, pericarpium citri reticulatae viride, bighead atractylodes rhizome, astragalus membranaceus and lucid ganoderma slices together by a conventional water extraction method twice, fermenting the extracting solution for 24 hours by using edible yeast, and then inactivating fungi at high temperature to obtain fermentation liquor;
s2, weighing 11 kinds of materials including ligusticum wallichii, pinellia ternate, radix bupleuri, radix curcumae, dandelion, selfheal, rhizoma sparganii, rhizoma zedoariae, herba patriniae, bock greenbrier rhizome and hairyvein agrimonia herb, washing with water, mixing with distilled water according to a mass ratio of 1:17, decocting together until boiling, keeping boiling for 3 minutes, extracting at 42 ℃ for 1.5 hours to obtain a primary extracting solution, pouring the distilled water into the primary extracting solution according to a mass ratio of 1:10, extracting at 42 ℃ for 1 hour to obtain a secondary extracting solution, filtering residues of the secondary extracting solution, concentrating the secondary extracting solution to obtain clear paste, refrigerating for 18 hours, taking supernate, filtering, and collecting mixed filtrate;
s3, mixing the fermentation liquor and the extracting solution together, and uniformly stirring in a reaction kettle for 35 minutes;
s4, filling the liquid material into a 50ML glass bottle by using a professional production line to obtain the xiapujin jiekang oral liquid.
Example 3
The invention relates to a Xiajujin Jiekang oral liquid, which comprises the following medicinal materials: 1.3 parts of largehead atractylodes rhizome, 1.1 parts of szechuan lovage rhizome, 1 part of glossy ganoderma slice, 1 part of pinellia tuber, 1.25 parts of Chinese thorowax root, 1.13 parts of turmeric root-tuber, 1.3 parts of green tangerine peel, 1.3 parts of dandelion, 1 part of summer cumin, 1.6 parts of poria cocos, 2 parts of bock greenbrier rhizome, 2 parts of astragalus root, 0.9 part of common burreed rhizome, 1 part of zedoary and 1.5 parts of dahurian patrinia herb.
The preparation method comprises the following steps:
the preparation method comprises the following steps:
s1, extracting 5 kinds of poria cocos, pericarpium citri reticulatae viride, bighead atractylodes rhizome, astragalus membranaceus and lucid ganoderma slices together by a conventional water extraction method twice, fermenting the extracting solution for 24 hours by using edible yeast, and then inactivating fungi at high temperature to obtain fermentation liquor;
s2, weighing 11 kinds of materials including ligusticum wallichii, pinellia ternate, radix bupleuri, radix curcumae, dandelion, selfheal, rhizoma sparganii, rhizoma zedoariae, herba patriniae, bock greenbrier rhizome and hairyvein agrimonia herb, washing with water, mixing with distilled water according to a mass ratio of 1:17, decocting together until boiling, keeping boiling for 4 minutes, extracting at 42 ℃ for 1.5 hours to obtain a primary extracting solution, pouring the distilled water into the primary extracting solution according to a mass ratio of 1:10, extracting at 42 ℃ for 1 hour to obtain a secondary extracting solution, filtering residues of the secondary extracting solution, concentrating the secondary extracting solution to obtain clear paste, refrigerating for 18 hours, taking supernate, filtering, and collecting mixed filtrate;
s3, mixing the fermentation liquor and the extracting solution together, and uniformly stirring in a reaction kettle for 35 minutes;
s4, filling the liquid material into a 50ML glass bottle by using a professional production line to obtain the xiapujin jiekang oral liquid.
The above description is only a preferred embodiment of the present invention, and not intended to limit the scope of the present invention, and all modifications and equivalents of the present invention, which are made by the present specification and directly/indirectly applied to other related technical fields within the spirit of the present invention are included in the scope of the present invention.
Claims (6)
1. The Xia pu jin jiekang oral liquid is characterized by comprising the following medicinal materials: 1-1.5 parts of bighead atractylodes rhizome, 1-1.2 parts of ligusticum wallichii, 1-1.7 parts of lucid ganoderma slices, 1-1.3 parts of pinellia ternate, 1.2-1.5 parts of radix bupleuri, 1-1.2 parts of radix curcumae, 1-1.5 parts of pericarpium citri reticulatae viride, 0.9-1.3 parts of dandelion, 1-1.5 parts of selfheal spike, 1.5-1.7 parts of poria cocos, 1.8-2 parts of rhizoma smilacis glabrae, 2-2.3 parts of astragalus membranaceus, 0.8-1 part of rhizoma sparganii, 1-1.1 parts of curcuma zedoary and 1.5-2 parts of patrinia scabiosaefolia.
The preparation method comprises the following steps:
s1, extracting 5 kinds of poria cocos, pericarpium citri reticulatae viride, bighead atractylodes rhizome, astragalus membranaceus and lucid ganoderma slices together by a conventional water extraction method twice, fermenting the extracting solution for 24 hours by using edible yeast, and then inactivating fungi at high temperature to obtain fermentation liquor;
s2, washing 11 kinds of materials including ligusticum wallichii, pinellia ternate, radix bupleuri, radix curcumae, dandelion, selfheal spike, rhizoma sparganii, curcuma zedoary, herba patriniae, bock greenbrier rhizome and hairyvein agrimonia herb, and extracting twice according to a water extraction process to obtain an extracting solution;
s3, mixing the fermentation liquor and the extracting solution together, and uniformly stirring in a reaction kettle for 35 minutes;
s4, filling the liquid material into a 50ML glass bottle by using a professional production line to obtain the xiapujin jiekang oral liquid.
2. The Xiajujin Jiekang oral liquid of claim 1, which is characterized by comprising the following medicinal materials: 1.5 parts of bighead atractylodes rhizome, 1 part of ligusticum wallichii, 1.5 parts of lucid ganoderma slices, 1 part of pinellia ternate, 1.5 parts of radix bupleuri, 1 part of radix curcumae, 1 part of pericarpium citri reticulatae viride, 1 part of dandelion, 1.5 parts of selfheal spike, 1.5 parts of poria cocos, 2 parts of bock greenbrier rhizome, 2 parts of astragalus membranaceus, 1 part of rhizoma sparganii, 1 part of curcuma zedoary and 2 parts of herba patriniae.
3. The Xiajujin Jiekang oral liquid of claim 1, which is characterized by comprising the following medicinal materials: 1 part of largehead atractylodes rhizome, 1.2 parts of szechuan lovage rhizome, 1.7 parts of lucid ganoderma slices, 1.3 parts of pinellia tuber, 1.2 parts of Chinese thorowax root, 1.1 parts of turmeric root tuber, 1.2 parts of green tangerine orange peel, 0.9 part of dandelion, 1.4 parts of selfheal spike, 1.7 parts of tuckahoe, 1.8 parts of bock greenbrier rhizome, 2.3 parts of astragalus root, 0.8 part of common burreed rhizome, 1.1 parts of zedoary and 2 parts of dahurian patrinia herb.
4. The Xiajujin Jiekang oral liquid of claim 1, which is characterized by comprising the following medicinal materials: 1.3 parts of largehead atractylodes rhizome, 1.1 parts of szechuan lovage rhizome, 1 part of glossy ganoderma slice, 1 part of pinellia tuber, 1.25 parts of Chinese thorowax root, 1.13 parts of turmeric root-tuber, 1.3 parts of green tangerine peel, 1.3 parts of dandelion, 1 part of summer cumin, 1.6 parts of poria cocos, 2 parts of bock greenbrier rhizome, 2 parts of astragalus root, 0.9 part of common burreed rhizome, 1 part of zedoary and 1.5 parts of dahurian patrinia herb.
5. The xiapu jin jiekang oral liquid of claim 1, wherein: the water extraction process in the S2 comprises the following steps: mixing 11 medicinal materials with distilled water at a mass ratio of 1:17, decocting until boiling, keeping boiling for 1-5 min, extracting at 42 deg.C for 1.5 hr to obtain a primary extractive solution, adding distilled water into the primary extractive solution at a mass ratio of 1:10, and extracting at 42 deg.C for 1 hr to obtain a secondary extractive solution.
6. The Xiajujin nodekang oral liquid of claim 5, wherein: filtering the secondary extractive solution, concentrating into fluid extract, refrigerating for 18 hr, collecting supernatant, filtering, and collecting mixed filtrate.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202011553326.9A CN112618679A (en) | 2020-12-24 | 2020-12-24 | Xiajujin Jiekang oral liquid and preparation method thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202011553326.9A CN112618679A (en) | 2020-12-24 | 2020-12-24 | Xiajujin Jiekang oral liquid and preparation method thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CN112618679A true CN112618679A (en) | 2021-04-09 |
Family
ID=75324489
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202011553326.9A Pending CN112618679A (en) | 2020-12-24 | 2020-12-24 | Xiajujin Jiekang oral liquid and preparation method thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN112618679A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114177244A (en) * | 2021-12-16 | 2022-03-15 | 浙江省人民医院 | Traditional Chinese medicine composition for treating thyroid cancer and preparation method thereof |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104524437A (en) * | 2014-12-11 | 2015-04-22 | 青岛市肿瘤医院 | Traditional Chinese medicine formula for treating thyroid carcinoma and preparation method of granules of traditional Chinese medicine formula |
CN106334155A (en) * | 2016-08-08 | 2017-01-18 | 青岛友诚高新技术有限公司 | Traditional Chinese medicine composition for treating arterial thyromegaly and preparation method thereof |
CN107582969A (en) * | 2017-09-21 | 2018-01-16 | 上海市普陀区中心医院 | A kind of compound preparation for treating AITD and preparation method thereof |
US20180092958A1 (en) * | 2015-06-03 | 2018-04-05 | Wonkwang University Center For Industry-Academy Cooperation | Composition for preventing, alleviating or treating neurodegenerative diseases |
-
2020
- 2020-12-24 CN CN202011553326.9A patent/CN112618679A/en active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104524437A (en) * | 2014-12-11 | 2015-04-22 | 青岛市肿瘤医院 | Traditional Chinese medicine formula for treating thyroid carcinoma and preparation method of granules of traditional Chinese medicine formula |
US20180092958A1 (en) * | 2015-06-03 | 2018-04-05 | Wonkwang University Center For Industry-Academy Cooperation | Composition for preventing, alleviating or treating neurodegenerative diseases |
CN106334155A (en) * | 2016-08-08 | 2017-01-18 | 青岛友诚高新技术有限公司 | Traditional Chinese medicine composition for treating arterial thyromegaly and preparation method thereof |
CN107582969A (en) * | 2017-09-21 | 2018-01-16 | 上海市普陀区中心医院 | A kind of compound preparation for treating AITD and preparation method thereof |
Non-Patent Citations (1)
Title |
---|
少林等: "散结消瘿汤治疗结节性甲状腺肿的临床观察", 《中国医学创新》 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114177244A (en) * | 2021-12-16 | 2022-03-15 | 浙江省人民医院 | Traditional Chinese medicine composition for treating thyroid cancer and preparation method thereof |
CN114177244B (en) * | 2021-12-16 | 2022-09-23 | 浙江省人民医院 | Traditional Chinese medicine composition for treating thyroid cancer and preparation method thereof |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN104288701A (en) | Traditional Chinese medicine composition for treating cholecystitis | |
CN113197974A (en) | Chinese medicinal composition for treating gastritis, gastric ulcer and duodenal ulcer | |
CN112618679A (en) | Xiajujin Jiekang oral liquid and preparation method thereof | |
CN104825736A (en) | Traditional Chinese medicine for treating hepatitis B | |
CN104998197A (en) | Traditional Chinese medicine composition for treating liver cancer | |
CN112237622B (en) | External traditional Chinese medicine composition for pasting and applying for acute and chronic gastroenteritis, abdominal pain and diarrhea, application paste, preparation method and application | |
CN104001131A (en) | Oral traditional Chinese medicine for preventing and treating stress ulcers | |
CN103751547A (en) | Traditional Chinese medicinal composition for reducing blood lipid and preparation method thereof | |
CN110898137A (en) | Pills for treating hyperthyroidism and preparation method and application thereof | |
CN112472776A (en) | Traditional Chinese medicine pill for treating gout and preparation method thereof | |
CN104998158A (en) | Pharmaceutical composition for treating liver cirrhosis and application thereof | |
CN104707110A (en) | Traditional Chinese medicine preparation for treating pancreatic cancer and preparation method thereof | |
CN108159389A (en) | One kind is used to treat prostatitic Chinese medicine composition and preparation method thereof | |
CN106237156A (en) | A kind of Chinese medicine composition treating gastric cancer and preparation method thereof | |
CN1830484A (en) | Memicine for treating body cold due to deficiency of blood and its preparation method | |
CN105853933A (en) | Traditional Chinese medicine preparation for treating postoperative recurrence and metastasis of breast cancer and preparing method | |
CN1062845A (en) | Control sexual impotence and aphrodisiac sexual recovery capsule | |
CN105012613A (en) | Beverage for treating fatty liver | |
CN100335111C (en) | Medicine for rheumatism and its preparation | |
CN118078920A (en) | Preparation for promoting blood circulation, removing blood stasis, dissolving thrombus and reducing three highs and preparation method thereof | |
CN104096202A (en) | Medicine for treating autumn diarrhea and preparation method of medicine | |
CN113181335A (en) | Acupoint application for treating bronchial asthma cold drink accumulation in lung and preparation method thereof | |
CN114668827A (en) | Traditional Chinese medicine formula for conditioning and using method thereof | |
CN115364153A (en) | She-flavor liver-protecting and stomach-nourishing formula | |
CN113230377A (en) | Traditional Chinese medicine electuary for treating wind-cold type common cold and preparation method thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20210409 |
|
RJ01 | Rejection of invention patent application after publication |