CN112618645A - Preparation method of male fertility-preparing nourishing traditional Chinese medicine preparation - Google Patents

Preparation method of male fertility-preparing nourishing traditional Chinese medicine preparation Download PDF

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CN112618645A
CN112618645A CN202110047131.5A CN202110047131A CN112618645A CN 112618645 A CN112618645 A CN 112618645A CN 202110047131 A CN202110047131 A CN 202110047131A CN 112618645 A CN112618645 A CN 112618645A
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grinding
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main shaft
parts
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臧星
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/64Orobanchaceae (Broom-rape family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48Reproductive organs
    • A61K35/50Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/29Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
    • A61K36/296Epimedium
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/34Campanulaceae (Bellflower family)
    • A61K36/344Codonopsis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/39Convolvulaceae (Morning-glory family), e.g. bindweed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/43Cuscutaceae (Dodder family), e.g. Cuscuta epithymum or greater dodder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/80Scrophulariaceae (Figwort family)
    • A61K36/804Rehmannia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/81Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815Lycium (desert-thorn)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/894Dioscoreaceae (Yam family)
    • A61K36/8945Dioscorea, e.g. yam, Chinese yam or water yam
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10Preparation or pretreatment of starting material
    • A61K2236/15Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction

Abstract

The invention discloses a preparation method of a male fertility-preparing nourishing traditional Chinese medicine preparation, which comprises the following components in parts by weight: 3-50 parts of cistanche, 3-50 parts of wolfberry fruit, 5-60 parts of epimedium, 5-100 parts of prepared rehmannia root, 5-100 parts of dodder, 3-50 parts of codonopsis pilosula, 3-55 parts of Chinese yam, 3-55 parts of curculigo orchioides, 3-55 parts of human placenta and 5-65 parts of deerhorn glue; the preparation method of the traditional Chinese medicine preparation comprises the following steps: placing the cistanche, the wolfberry fruit, the prepared rehmannia root, the codonopsis pilosula, the common yam rhizome and the curculigo orchioides into grinding equipment according to the mass ratio, mixing and grinding, spraying physiological saline, and drying to obtain prefabricated coarse powder; mixing herba Epimedii and semen Cuscutae, soaking in 5-10 times of water for more than 4 hr, decocting with slow fire, filtering, adding coarse powder into the filtrate, and concentrating to obtain premixed solution I; adding placenta hominis fine powder into colla Cornus Cervi, spraying yellow wine, stirring, and sealing for 48-100 hr to obtain premixed solution I I; mixing the premix solution I and the premix solution I I, and making into Chinese medicinal preparation with adjuvants.

Description

Preparation method of male fertility-preparing nourishing traditional Chinese medicine preparation
Technical Field
The invention relates to the technical field of Chinese herbal medicines, in particular to a preparation method of a male fertility-preparing nourishing traditional Chinese medicine.
Background
With the acceleration of life rhythm, the increase of working and living pressure and the deterioration of environment, the incidence rate of infertility in recent years is more serious and has a trend of rising year by year, according to the statistics of the world health organization, the infertility caused by male factors accounts for 30-40% of the total incidence rate, and the main reasons for causing male infertility are as follows: (1) semen abnormalities such as azoospermia, oligospermia, asthenospermia, etc.; (2) spermatogenic dysfunction due to chromosomal abnormalities; (3) sperm cannot be transported due to obstruction of the vas deferens; (4) systemic factors such as sudden changes in living environment, long-term mental stress, prolonged working in a high or adverse environment, endocrine imbalance, etc. Most of the diseases are caused by semen abnormality, mental stress, body endocrine imbalance and the like. Aiming at the problems, the existing treatment commonly used for male infertility mainly adopts sex hormone medicines to regulate internal secretion and adopts Chinese herbal medicines to condition, compared with the simple administration of sex hormone medicines, the side effect is great, the balance in the machine is influenced, the advantages of the traditional Chinese medicine in the aspects of treating and conditioning the male infertility are very obvious, but the existing Chinese herbal medicine conditioning medicines emphasize on tonifying liver and kidney, on one hand, the integral treatment principle of the traditional Chinese medicine is not reflected, on the other hand, the defects of difficult absorption, easy fire rising, unsatisfactory curative effect and high price exist, and most of the traditional Chinese herbal medicines in the prior art adopt the traditional water decoction method as the mainstream, so the taking is inconvenient. Therefore, research and development of novel Chinese herbal medicines for helping men get rid of infertility troubles and simultaneously nourishing and regulating comprehensive functions of organisms have important significance for various families and national fertility policies.
Disclosure of Invention
The invention provides a preparation method of a male fertility-preparing nourishing traditional Chinese medicine preparation for overcoming the defects of the prior art, and aims to solve the problems of poor absorption efficiency, easiness in getting excessive internal heat, low curative effect, inconvenience in taking and the like of the existing male infertility.
In order to achieve the purpose, the invention adopts the following technical scheme: a preparation method of a male fertility-preparing nourishing traditional Chinese medicine preparation comprises the following raw materials in parts by weight: 3-50 parts of cistanche, 3-50 parts of wolfberry fruit, 5-60 parts of epimedium, 5-100 parts of prepared rehmannia root, 5-100 parts of dodder, 3-50 parts of codonopsis pilosula, 3-55 parts of Chinese yam, 3-55 parts of curculigo orchioides, 3-55 parts of human placenta and 5-65 parts of deerhorn glue;
the preparation method of the traditional Chinese medicine preparation comprises the following steps:
step a: putting the cistanche, the wolfberry fruit, the prepared rehmannia root, the codonopsis pilosula, the common yam rhizome and the curculigo orchioides into grinding equipment according to the mass ratio, uniformly mixing, grinding into 20-40 meshes of coarse powder, immersing or spraying normal saline for 5-8 minutes, and drying to obtain prefabricated coarse powder;
step b: b, mixing the epimedium herb and the dodder, soaking the mixture in water which is 5-10 times of the total mass of the mixture for more than 4 hours, decocting the mixture for 40-60 minutes with slow fire, taking filtrate, adding the prepared coarse powder obtained in the step a into the filtrate, and concentrating the filtrate to obtain a premixed solution I;
step c: pulverizing placenta hominis into fine powder, adding into colla cornus cervi, spraying yellow wine, stirring, sealing for 48-100 hr to obtain premixed solution II;
step d: mixing the premixed solution I and the premixed solution II, and preparing a traditional Chinese medicine preparation by auxiliary materials, wherein the traditional Chinese medicine preparation is a pill, a pellet, an ointment or powder;
the grinding device in the step a comprises a machine body, a grinding barrel fixedly arranged on the machine body, a first grinding device arranged in the grinding barrel, a filling device arranged on the grinding barrel and used for adding cistanche, wolfberry fruit, prepared rehmannia root, codonopsis pilosula, common yam rhizome and rhizoma curculiginis, a discharge pipe fixedly arranged at the bottom of the grinding barrel, and a second grinding device arranged in the discharge pipe, wherein the first grinding device comprises a driving main shaft, an eccentric shaft fixedly sleeved on the driving main shaft, a grinding roller rotatably sleeved on the eccentric shaft, a cavity arranged in the grinding roller, a plurality of first grooves annularly distributed at equal intervals on the grinding roller, a first through hole arranged on the grinding roller and used for communicating the cavity with the first grooves, a plurality of first push plates respectively movably arranged in the first grooves, and a plurality of first guide rods, one end of which is fixedly arranged on the first push plates, and the other end of which can be movably inserted into the grinding roller, The grinding machine comprises a volute plate fixedly sleeved on a driving main shaft, a conical surface arranged on a grinding roller, a first gear fixedly arranged on the grinding roller, a first internal gear fixedly arranged on a grinding barrel and matched with the first gear, a motor fixedly arranged on a machine body and used for driving the driving main shaft to rotate, a circular plate rotatably sleeved on the driving main shaft and fixedly arranged on the grinding barrel, and a plurality of blanking ports annularly distributed on the circular plate at equal intervals; the blanking port gradually becomes wider from outside to inside; the vortex plate is positioned between the bottom of the grinding barrel and the bottom of the grinding roller; firstly, continuously adding cistanche, wolfberry fruit, prepared rehmannia root, codonopsis pilosula, common yam rhizome and common curculigo rhizome into a filling device, driving a driving main shaft to rotate through the driving of a motor, driving the whole filling device to operate, uniformly stirring the cistanche, the wolfberry fruit, the prepared rehmannia root, the codonopsis pilosula, the common yam rhizome and the common curculigo rhizome in the filling device, uniformly putting the mixture between a grinding roller and a grinding barrel, driving the driving main shaft to rotate through the driving of the motor, driving an eccentric shaft to rotate by the rotation of the driving main shaft, driving the grinding roller to rotate by taking the driving main shaft as an axis, driving the grinding roller to roll on the inner wall of the grinding barrel by the eccentric shaft through the arrangement of a first gear and a first inner gear, grinding the mixture of the cistanche, the wolfberry fruit, the prepared rehmannia root, the codonopsis pilosula, the common yam rhizome and the common curculigo rhizome by the first gear along the first, move to the plectane direction promptly, get into in the discharge tube through a plurality of blanking mouths at last, the drive main shaft drives the second grinder and grinds the mixture in the discharge tube once more, accomplishes and mixes and grinds cistanche salsa, the fruit of Chinese wolfberry, prepared rehmannia root, radix codonopsitis, huai-shan yam and curculigo rhizome. The traditional Chinese medicine preparation provided by the invention adopts ten edible and medicinal traditional Chinese medicinal materials of cistanche, wolfberry fruit, herba epimedii, prepared rehmannia root, dodder seed, codonopsis pilosula, Chinese yam, rhizoma curculiginis, human placenta and antler glue as raw materials, and is prepared in a scientific proportion, so that the traditional Chinese medicine preparation has the effects of nourishing yin and tonifying yang, and nourishing liver, kidney and spleen. Cistanche deserticola, sweet and salty in taste and warm in nature, enters kidney and large intestine channels and tonifies kidney yang; replenishing essence and blood; moistening intestinal tract. It is mainly used for impotence, spermatorrhea and whitish and turbid urine due to kidney yang deficiency and essence and blood deficiency; the cistanche salsa is rich in phenylethanoid glycosides, polysaccharides, amino acids, iridoids, lignans, various alkaloids, vitamins and mineral rare nutrient nourishing components, has the effects of regulating endocrine, improving the immunity of organisms, promoting metabolism and strengthening, especially has great tonifying effects on sexual organs such as male kidney, testis, penis, cavernous body and the like, and can effectively improve the vitality and quality of sperms. Wolfberry fruit, fructus lycii, sweet in nature and taste, is neutral in nature and flavor, enters liver and kidney channels, and has the effects of nourishing liver and kidney, replenishing vital essence to improve eyesight, strengthening body and strengthening body. The fructus Lycii polysaccharide can increase serum sex hormone level of injured testis, increase organ coefficient of testis and epididymis, and the fructus Lycii and Cistanchis herba enter kidney meridian together, and improve the activity of superoxide dismutase (SOD) of testis tissue, reduce malondialdehyde content, prevent mitochondrial aging, and recover injured testis tissue to near normal level. Herba Epimedii, also known as herba Epimedii, is pungent in flavor, warm, nontoxic, and effective in invigorating vital essence, invigorating kidney, supporting yang, dispelling pathogenic wind, removing dampness, strengthening tendons and bones, and treating sexual impotence, spermatorrhea, and infertility due to deficiency cold. Shu Di Huang is sweet in flavor and slightly warm in nature, and enters liver and kidney meridians. Has effects of nourishing yin, replenishing blood, replenishing essence, replenishing marrow, and enhancing immunity, and can be used for tonifying liver, spleen, and kidney, and radix rehmanniae Preparata and rhizoma Dioscoreae can be used for treating deficiency of liver-yin and kidney-yin, soreness of waist and knees, and spermatorrhea. Semen Cuscutae has sweet taste and warm nature, and has effects of nourishing liver and kidney, stopping nocturnal emission, reducing urination, invigorating yang, nourishing yin, regulating yin and yang balance, and tonifying kidney, liver and spleen. The codonopsis pilosula is sweet in taste and neutral in nature, and has the effects of tonifying middle-jiao and Qi, harmonizing stomach and promoting fluid production, enhancing immunity, enhancing hematopoietic function and the like. The yam is sweet in taste, neutral in nature, and rich in nutritional ingredients such as protein, saccharides, vitamins, crude protein amino acids, trace elements and the like, and has the effects of tonifying spleen and nourishing stomach, promoting fluid production and benefiting lung, tonifying kidney and arresting seminal emission, and clearing heat and toxic materials, and is preferably the yam. Curculigo orchioides has the functions of invigorating kidney, tonifying yang, benefiting essence and blood, strengthening bones and muscles, promoting blood circulation and relieving swelling. Placenta hominis, sweet, salty and warm in taste, enters lung, heart and kidney meridians, is rich in protein, sugar, vitamins, immune factors, progesterone, steroid hormone, gonadotropin and the like, and has the effects of tonifying kidney, replenishing vital essence, tonifying qi, nourishing blood and enhancing body immunity. The antler glue has sweet, salty and warm properties, can warm and nourish liver and kidney and has the efficacy of replenishing essence and blood, the compatibility of the medicines has the synergistic effect, and thick products such as prepared rehmannia root, human placenta, sperms and antler glue are selected to nourish kidney and replenish essence so as to enrich kidney yin dew; the epimedium, the dodder and the curculigo orchioides are used for warming and nourishing yang essence of the Mingmen, and the mutual growth of yin and heaven and earth in yang is achieved, so that yin can be transformed and promoted by yang to be infinite; radix Codonopsis and rhizoma Dioscoreae have the effects of invigorating qi and spleen, and promoting the generation of food essence to supplement the source of kidney essence. The medicines are combined to obtain the source of nourishing kidney and promoting sperm reproduction. The preparation method of the traditional Chinese medicine preparation is comprehensively researched and developed on the basis of fully considering the pharmacology, the drug effect exertion and the mutual influence of all medicines, firstly, the cistanche, the barbary wolfberry fruit, the prepared rehmannia root, the pilose asiabell root, the common yam rhizome and the common curculigo rhizome are uniformly mixed according to the mass ratio, are ground into coarse powder, are immersed or sprayed with 0.9 percent of physiological saline for 5-8 minutes to achieve the state of surface wetting and internal drying, and are dried to obtain prefabricated coarse powder for later use; mixing herba Epimedii and semen Cuscutae, soaking in water for more than 4 hr, decocting with slow fire for 40-60 min to fully extract effective active substances, collecting filtrate, adding the coarse powder into the filtrate, and concentrating to obtain premixed solution I; and finally, adding the ultrafine powder of placenta hominis into the antler glue which is decocted into a fluid extract, spraying yellow wine, uniformly stirring, sealing for 48-100h to obtain a premixed solution II, mixing the premixed solution I and the premixed solution II, and preparing pills with various specifications by using auxiliary materials such as dextrin, starch and the like. The traditional Chinese medicine is prepared by mixing six medicinal materials of cistanche, wolfberry fruit, prepared rehmannia root, codonopsis pilosula, Chinese yam rhizome and rhizoma curculiginis into the medicine by ground coarse powder, extracting the epimedium herb and the dodder with water, preparing human placenta and antler glue which is decocted into a fluid extract, and using yellow wine as a guiding drug. Furthermore, the traditional theory of balancing yin and yang of human body in traditional Chinese medicine is taken as a great method, so that heaven and earth are obtained, and heaven and earth are also obtained. The dry one is yang in nature and the female one is yin in nature. Tian has yang essence, and Di has yin essence. The male fetus beads can also promote the yang qi of male sperms (Y type) in the semen so as to be preferentially combined with ova (X type) discharged by women to form male fetus beads (XY fertilized ova) which are more beneficial to the inoculation of healthy male fetus.
In the step b, the epimedium and the dodder are mixed, soaked for more than 6 hours at 20-40 ℃ by using water with the total mass being 6-8 times of that of the epimedium and the dodder, and the obtained premixed liquid I is a fluid extract.
The grinding barrel comprises a barrel body, a plurality of second grooves which are distributed on the inner wall of the barrel body in an equidistant annular mode, a plurality of second push plates which are respectively movably arranged in the plurality of second grooves, a plurality of connecting cavities which are fixedly arranged on the machine body in a one-to-one correspondence mode with the plurality of second grooves, a plurality of sleeves of which two ends are respectively fixedly arranged on the connecting cavities and the barrel body, a first push rod which is movably arranged in one of the sleeves and one end of which is attached to the first gear, a plurality of second push rods which are respectively movably arranged in the other sleeves and one end of which is fixedly arranged on the second push plates, and a spring which is sleeved on the first push rod and of which two ends are respectively fixedly arranged on the inner wall of the barrel body and one end of the first; first gear rotates the in-process along first internal gear and promotes first push rod in a plurality of sleeves in proper order and removes to connecting the chamber direction, connects intracavity space and diminishes, and a plurality of second push rods of drive are kept away from and are connected the chamber, promote the second push pedal promptly and remove to the middle department in the staving, and the second push pedal inboard and staving inner wall coincidence reset first push rod through the spring, reset the second push pedal promptly.
The packing device comprises a stirring barrel, a plurality of first feeding pipes, a rotary disc, a plurality of second feeding pipes, a second gear, a plurality of third gears, a second internal gear and a plurality of stirring blades, wherein the two ends of the first feeding pipes are distributed in an equidistant annular mode and are fixedly arranged on the stirring barrel and the barrel body respectively for communicating the first feeding pipes and the barrel body; cistanche, wolfberry fruit, prepared rehmannia root, dangshen, common yam rhizome and common curculigo rhizome are in one-to-one correspondence with a plurality of second feeding pipes, namely, the cistanche, the wolfberry fruit, the prepared rehmannia root, the dangshen, the common yam rhizome and the common curculigo rhizome are added into the stirring barrel through the plurality of second feeding pipes, the driving spindle drives the second gear to rotate in the rotating process, the second gear drives the third gear to rotate in the rotating process, the third gear drives the third gear to revolve around the driving spindle as the axis and to self-transmit, the third gear drives the second feeding pipes to rotate in the self-transmitting process, the stirring blades are driven to rotate in the rotating process of the second feeding pipes, namely, the stirring blades revolve around the driving spindle as the axis in the self-transmitting process, the cistanche, the wolfberry fruit, the prepared rehmannia root, the dangshen, the common yam rhizome and the curculigo rhizome are mixed and.
The stirring blade comprises a blade body, a first inclined plane, a second inclined plane, a third inclined plane and a fourth inclined plane which are arranged on the blade body, a plurality of first material guide grooves which are obliquely arranged on the blade body at equal intervals, and a plurality of second material guide grooves which are staggered with the first material guide grooves, wherein the inclination angles of the first material guide grooves and the second material guide grooves are opposite; set up through first inclined plane to fourth inclined plane and keep away from the second charge tube direction to cistanche deserticola in the agitator, the wolfberry fruit, the preparation of rehmannia, the codonopsis pilosula, it removes to say that chinese yam and curculigo orchioides, carry out the water conservancy diversion through cistanche deserticola in first baffle box and the second baffle box to the agitator, the wolfberry fruit, the preparation of rehmannia, the codonopsis pilosula, it carries out the water conservancy diversion to say that chinese yam and curculigo orchioides, the blade body rotates the in-process promptly and stirs the limit and keeps away from the blade body simultaneously to cistanche deserticola, the wolfberry fruit.
The second grinding device comprises a fixed disk which is sleeved on the driving main shaft in a rotating mode, an inserting rod which is arranged on the fixed disk and the discharging pipe in a penetrating mode simultaneously, a third internal gear which is fixedly arranged on the fixed disk, a fourth gear which is fixedly sleeved on the driving main shaft in a rotating mode, a first disk which is sleeved on the driving main shaft in a rotating mode, a plurality of fifth gears which are annularly distributed and arranged on the first disk in an rotating mode and are respectively meshed with the fourth gear and the third internal gear, a sleeve seat which is rotatably sleeved on the fixed disk and is fixedly arranged on the first disk, a fourth internal gear which is fixedly sleeved on the fixed disk in a rotating mode, a sixth gear which is fixedly sleeved on the sleeve seat in a rotating mode, a second disk which is rotatably sleeved on the sleeve seat in an equidistant mode, a plurality of seventh gears which are annularly distributed and arranged on the second disk in a rotating mode and are respectively meshed with the sixth, A plurality of second lugs fixedly arranged on the second disc in an equidistant annular distribution manner, a plurality of third lugs and a plurality of fourth lugs fixedly arranged on the inner wall of the discharge pipe in an equidistant annular distribution manner, and a conical circular plate fixedly arranged on the first disc and rotatably sleeved on the driving main shaft; the first lug and the second lug are identical in structure, the first lug comprises a first body, a first arc-shaped surface arranged on the first body, a fifth inclined surface and a sixth inclined surface arranged on the first body, and the first arc-shaped surface is attached to the inner wall of the discharge pipe; the third bump and the fourth bump have the same structure, the third bump comprises a second body, a second arc-shaped surface arranged on the second body, a seventh inclined surface and an eighth inclined surface arranged on the second body, the second arc-shaped surface on the third bump is attached to the sleeve seat, and the second arc-shaped surface on the fourth bump is attached to the fourth inner gear; the distance between two adjacent first lugs is greater than the distance between two adjacent second lugs; the distance between two adjacent third bumps is greater than the distance between two adjacent fourth bumps; the fourth gear is driven to rotate in the rotation process of the driving main shaft, the fourth gear is driven to rotate by the third internal gear to drive the fifth gears to revolve with the driving main shaft as an axis, the first disc is driven to rotate in the revolution process of the driving main shaft, the first lugs are driven to revolve in the rotation process of the first disc, the sleeve seat is driven to rotate by the rotation of the first disc, the sixth gear is driven to rotate by the rotation of the sleeve seat, the seventh gears are driven to revolve with the driving main shaft as an axis in the rotation process of the sixth gear by the fourth internal gear, the second disc is driven to rotate in the revolution process of the seventh gears, the second lugs are driven to revolve in the rotation process of the second disc, the mixture enters the discharge pipe and moves towards the first lugs by the arrangement of the conical circular plate and passes through the space between two adjacent first lugs, and the mixture is sheared into small particles by the arrangement of the first lugs and the third lugs, after the mixture is sheared, the mixture penetrates through the two adjacent second lugs, the mixture is sheared into smaller particles again through the revolution of the plurality of second lugs and the fourth lugs, the mixture particles meeting the requirements pass through the two adjacent fourth lugs, and the mixture of the cistanche, the wolfberry fruit, the prepared rehmannia root, the codonopsis pilosula, the common yam rhizome and the common curculigo rhizome is ground again.
The invention has the following advantages: the traditional Chinese medicine preparation provided by the invention is scientific and simplified in formula and precise in compatibility, has good curative effects on male liver and kidney nourishing and yin and yang regulation, has the effects of improving the number of sperm survival and the motility of semen, and is more surprising in that the yang qi of male sperms (Y-type) is obviously improved, thereby being beneficial to the inoculation of healthy male fetus. The preparation method is simple and scientific, the components of the medicines are uniform and moderate, the effective components of the medicines are fully exerted, and the efficacy of the formula for reinforcing the yang of the liver, spleen and kidney can be obviously enhanced.
Drawings
FIG. 1 is a schematic structural diagram of the present invention.
Fig. 2 is a side view of the present invention.
Fig. 3 is a sectional view taken along line a-a of fig. 2.
Fig. 4 is an enlarged view of a portion a in fig. 3.
Fig. 5 is a sectional view taken along line B-B of fig. 3.
Fig. 6 is a sectional view taken along line C-C of fig. 3.
Fig. 7 is a cross-sectional view taken along line D-D of fig. 3.
Fig. 8 is a sectional view taken along line E-E of fig. 3.
Fig. 9 is a sectional view taken along line F-F in fig. 5.
Fig. 10 is a sectional view taken along line G-G in fig. 3.
Fig. 11 is a partial sectional view taken along line H-H in fig. 3.
Fig. 12 is a partial sectional view taken along line I-I in fig. 3.
Fig. 13 is a schematic structural view of a second polishing apparatus.
Detailed Description
In order to make the technical solutions of the present invention better understood, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
As shown in fig. 1-13, a preparation method of a tonic traditional Chinese medicine for male fertility preparation:
example 1
The formula is as follows: 5g of cistanche, 5g of medlar, 8 g of epimedium, 10 g of prepared rehmannia root, 10 g of dodder, 5g of codonopsis pilosula, 5g of Chinese yam, 5g of curculigo orchioides, 5g of human placenta and 7 g of deerhorn glue.
The preparation method comprises the following steps:
step a: putting the cistanche, the wolfberry fruit, the prepared rehmannia root, the codonopsis pilosula, the common yam rhizome and the common curculigo rhizome into grinding equipment according to the mass ratio, uniformly mixing, grinding into coarse powder of 30 meshes, immersing or spraying 0.9% physiological saline for 5 minutes to enable the mixture to be in a yin-yang state with dry exterior, dampness and interior, then placing the mixture in a ventilated and cool place, and naturally drying for 72 hours to obtain prefabricated coarse powder for later use;
step b: b, mixing the epimedium herb and the dodder, soaking for 4 hours in 100 g of water, decocting for 60 minutes with slow fire, taking the filtrate, adding the prepared coarse powder obtained in the step a into the filtrate, and concentrating into fluid extract, wherein each 1ml of the fluid extract is equivalent to 1g of the original medicinal material, so as to obtain a premixed solution I;
step c: pulverizing placenta hominis into 200 mesh fine powder, adding into decocted fluid extract of colla Cornus Cervi, wherein each 1ml of fluid extract of colla Cornus Cervi is equal to 1g of raw medicinal material, spraying 1g of yellow wine, stirring, and sealing for 72 hr to obtain premixed solution II;
step d: mixing the premix solution I and the premix solution II to prepare pills of 15 g/pill;
the grinding equipment in the step a comprises a machine body (1), a grinding barrel (2) fixedly arranged on the machine body, a first grinding device (3) arranged in the grinding barrel, a filling device (4) arranged on the grinding barrel and used for adding cistanche, wolfberry fruit, prepared rehmannia root, codonopsis pilosula, common yam rhizome and rhizoma curculiginis, a discharge pipe (5) fixedly arranged at the bottom of the grinding barrel, and a second grinding device (6) arranged in the discharge pipe, wherein the first grinding device (3) comprises a driving main shaft (31), an eccentric shaft (32) fixedly arranged on the driving main shaft, a grinding roller (33) rotatably sleeved on the eccentric shaft, a cavity (34) arranged in the grinding roller, a plurality of first grooves (35) annularly distributed on the grinding roller at equal intervals, a first through hole (36) arranged on the grinding roller and used for communicating the cavity with the first grooves, a plurality of first push plates (37) respectively movably arranged in the first grooves, The grinding machine comprises a plurality of first guide rods (38), a volute plate (39), a conical surface (310), a first gear (311), a first internal gear (312), a motor (313), a circular plate (314) and a plurality of blanking ports (315), wherein one end of each first guide rod is fixedly arranged on a first push plate, the other end of each first guide rod is movably inserted into a grinding roller, the volute plate is fixedly sleeved on a driving main shaft, the conical surface (310) is arranged on the grinding roller, the first gear (311) is fixedly arranged on the grinding roller, the first internal gear (312) is fixedly arranged on a grinding barrel and matched with the first gear, the motor (313) is fixedly arranged on a machine body and used; the blanking port gradually becomes wider from outside to inside; the vortex plate is positioned between the bottom of the grinding barrel and the bottom of the grinding roller; firstly, continuously adding cistanche, wolfberry fruit, prepared rehmannia root, codonopsis pilosula, Chinese yam and rhizoma curculiginis into a filling device, driving a main shaft to rotate through a motor to enable the filling device to integrally operate, uniformly stirring the cistanche, the wolfberry fruit, the prepared rehmannia root, the codonopsis pilosula, the Chinese yam and the rhizoma curculiginis in the filling device, uniformly putting the mixture between a grinding roller and a grinding barrel, driving the main shaft to rotate through the motor to enable an eccentric shaft to rotate, enabling the grinding roller to rotate by taking the driving main shaft as an axis, enabling the eccentric shaft to drive the grinding roller to roll on the inner wall of the grinding barrel through a first gear and a first internal gear, enabling the first gear to rotate along the first internal gear, grinding and grinding the mixture of the cistanche, the wolfberry fruit, the prepared rehmannia root, the codonopsis pilosula, the Chinese yam and the rhizoma curculiginis between the grinding barrel and the grinding roller, The grinding device comprises a driving main shaft, a vortex plate, a plurality of blanking ports, a second grinding device, a grinding machine and a grinding machine, wherein the materials of the pilose asiabell root, the Chinese yam rhizome and the common curculigo rhizome are ground and ground, the vortex plate is driven by the driving main shaft to rotate, the mixture after grinding is gathered to the center of the driving main shaft, the mixture moves towards the direction of a circular plate, and finally enters the discharging pipe through the blanking ports, the mixture can be cut again through the arrangement of the circular plate and the vortex plate, the blanking ports are gradually widened from outside to inside, the mixture is prevented from blocking the blanking ports, the mixture forms shearing through dislocation of the vortex plate and the blanking ports when passing through the blanking ports, the mixture moves towards the direction, The common yam rhizome and the common curculigo rhizome are mixed more uniformly and can reach the required coarse powder; the grinding roller rolls along the inner wall of the grinding barrel to grind the mixture, so that the mixture can be quickly ground, more mixture is added, the grinding efficiency is improved, the mixture and the mixture are extruded, the grinding efficiency is improved, the mixture is prevented from being accumulated by the arrangement of the conical surface, meanwhile, the mixture can be positioned between the grinding roller and the grinding barrel, the mixture is the mixture of cistanche salsa, wolfberry fruit, prepared rehmannia root, codonopsis pilosula, common yam rhizome and common curculigo rhizome, the grinding roller is arranged by a plurality of first push plates in the process of rolling along the inner wall of the grinding barrel, so that the grinding roller can drive a part of the mixture to rotate, the grinding work of the mixture is accelerated, even the mixture is ground through the rolling of the grinding roller and the grinding barrel quickly, namely, the reaction force generated after the mixture is rolled by the grinding roller is reduced, so that the mixture quickly passes through the minimum gap between the grinding roller and the grinding barrel.
In the step b, the epimedium and the dodder are mixed, soaked for more than 6 hours at 20-40 ℃ by using water with the total mass being 6-8 times of that of the epimedium and the dodder, and the obtained premixed liquid I is a fluid extract.
The grinding barrel (2) comprises a barrel body (21), a plurality of second grooves (22) which are distributed on the inner wall of the barrel body in an equidistant annular mode, a plurality of second push plates (23) which are respectively and movably arranged in the plurality of second grooves, a plurality of connecting cavities (24) which are fixedly arranged on the machine body in a one-to-one correspondence mode with the plurality of second grooves, a plurality of sleeves (25) of which two ends are respectively and fixedly arranged on the connecting cavities and the barrel body, a first push rod (26) which is movably arranged in one of the sleeves and one end of which is attached to the first gear, a plurality of second push rods (27) which are respectively and movably arranged in the other sleeves and of which one end is fixedly arranged on the second push plates, and a spring (28) which is sleeved on the first push rod and of which two ends are respectively and fixedly arranged on the; the first gear sequentially pushes the first push rods in the plurality of sleeves to move towards the connecting cavity in the rotating process of the first inner gear, so that the space in the connecting cavity is reduced, the plurality of second push rods are far away from the connecting cavity, namely, the second push plate is pushed to move towards the middle part in the barrel body, so that the inner side of the second push plate is superposed with the inner wall of the barrel body, the extrusion force between the second push plate and the grinding roller is improved through the arrangement, the grinding efficiency is improved again, the first push rod is reset through the spring, reset the second push pedal promptly, the second push pedal is restoreed the back, makes the mixture can get into the second inslot, makes the inner wall of staving form unsmooth, improves the bulk friction of mixture and staving inner wall, avoids the mixture to receive extrusion reverse movement, grinds to roll when being located second push pedal department with staving inner wall clearance minimum, the second push pedal can with staving inner wall coincidence, does not influence grinding of rolling of mixture promptly.
The filling device (4) comprises a stirring barrel (41), a plurality of first feeding pipes (42) which are respectively fixedly arranged on the stirring barrel and the barrel body at two ends in an equidistant annular distribution and are used for being communicated with each other, a rotary disc (43) which is rotatably sleeved on a driving main shaft and is rotatably arranged on the inner wall of the stirring barrel, a plurality of second feeding pipes (44) which are respectively arranged on the rotary disc in an equidistant annular distribution and penetrate through the rotary disc, a second gear (45) fixedly sleeved on the driving main shaft, a plurality of third gears (46) which are respectively fixedly sleeved on the plurality of second feeding pipes and are meshed with the second gears, a second inner gear (47) which is fixedly arranged on the stirring barrel and is meshed with the plurality of third gears, and a plurality of stirring blades (48) which are fixedly arranged on the; cistanche, wolfberry fruit, prepared rehmannia root, dangshen, dioscorea opposita and rhizoma curculiginis are in one-to-one correspondence with a plurality of second feeding pipes, namely the cistanche, the wolfberry fruit, the prepared rehmannia root, the codonopsis pilosula, the dioscorea opposita and the rhizoma curculiginis are added into a stirring barrel through the plurality of second feeding pipes, a second gear is rotated in the rotation process of a driving main shaft, a third gear is rotated in the rotation process of the second gear, the third gear is revolved and self-transmitted by taking the driving main shaft as an axis through the arrangement of a second internal gear, a turntable is rotated at the same time, the second feeding pipe is self-transmitted in the self-transmission process of the third gear, stirring blades are rotated in the rotation process of the second feeding pipe, stirring is carried out while feeding, namely the stirring blades revolve by taking the driving main shaft as the axis through self-transmission, the cistanche, the wolfberry fruit, the prepared rehmannia root, the codonopsis pilosula, the dioscorea opposita and, through the revolution of the plurality of second feeding pipes, accumulation is avoided during feeding, materials can be uniformly dispersed, and the revolution stirring is carried out while the materials are stirred by the stirring blades in a self-transmission mode, so that the stirring effect is greatly improved.
The stirring blade (48) comprises a blade body (481), a first inclined surface (482), a second inclined surface (483), a third inclined surface (484), a fourth inclined surface (485) which are arranged on the blade body, a plurality of first guide chutes (486) which are obliquely arranged on the blade body at equal intervals, and a plurality of second guide chutes (487) which are staggered with the plurality of first guide chutes, wherein the inclination angles of the first guide chutes and the second guide chutes are opposite; set up the cistanche salsa to the agitator in through first inclined plane to fourth inclined plane, the wolfberry fruit, the prepared rehmannia root, the radix Codonopsis Pilosulae, it keeps away from the second inlet tube direction removal to huai chinese yam and curculigo rhizome mixture, avoid the mixture to pile up in blade body department, avoid the mixture in the agitator to produce and remain promptly, make in the mixture can be whole gets into a plurality of first inlet tubes, through the cistanche salsa of first baffle box and second baffle box in to the agitator, the wolfberry fruit, the prepared rehmannia root, huai chinese yam and curculigo rhizome carry out the water conservancy diversion, change the direction of its stirring, improve the effect of stirring, simultaneously can reduce the resistance that the blade body received, the effect that improves the stirring simultaneously can be laborsaving again, promptly blade body rotates the in-process limit to cistanche salsa, the wolfberry fruit, the prepared rehmannia root, radix Codonopsis Piper hanceis and curculigo on.
The second grinding device (6) comprises a fixed disc (61) which is sleeved on the driving main shaft in a rotating mode, an inserting rod (62) which is arranged on the fixed disc and the discharging pipe in a penetrating mode, a third internal gear (63) which is fixedly arranged on the fixed disc, a fourth gear (64) which is fixedly sleeved on the driving main shaft, a first disc (65) which is sleeved on the driving main shaft in a rotating mode, a plurality of fifth gears (66) which are arranged on the first disc in an equidistant annular distribution mode and are respectively meshed with the fourth gear and the third internal gear, a sleeve seat (67) which is arranged on the fixed disc in a rotating mode and is fixedly arranged on the first disc, a fourth internal gear (68) which is fixedly sleeved on the fixed disc, a sixth gear (69) which is fixedly sleeved on the sleeve seat, a second disc (610) which is arranged on the sleeve seat in a rotating mode, a plurality of seventh gears (611) which are arranged on the second disc, A plurality of first lugs (612) which are distributed and fixed on the first disc in an equidistant annular manner, a plurality of second lugs (613) which are distributed and fixed on the second disc in an equidistant annular manner, a plurality of third lugs (614) and a plurality of fourth lugs (615) which are distributed and fixed on the inner wall of the discharge pipe in an equidistant annular manner, and a conical round plate (621) which is fixed on the first disc and is rotationally sleeved on the driving main shaft; the first bump and the second bump are identical in structure, the first bump comprises a first body (616), a first arc-shaped surface (617) arranged on the first body, a fifth inclined surface (618) and a sixth inclined surface (619) arranged on the first body, and the first arc-shaped surface is attached to the inner wall of the discharge pipe; the third bump and the fourth bump have the same structure, the third bump comprises a second body (620), a second arc-shaped surface arranged on the second body, a seventh inclined surface (622) and an eighth inclined surface (623) arranged on the second body, the second arc-shaped surface on the third bump is attached to the sleeve seat, and the second arc-shaped surface on the fourth bump is attached to the fourth inner gear; the distance between two adjacent first lugs is greater than the distance between two adjacent second lugs; the distance between two adjacent third bumps is greater than the distance between two adjacent fourth bumps; the fourth gear is rotated in the rotation process of the driving spindle, the fourth gear is rotated through the arrangement of the third internal gear, the fifth gears revolve around the driving spindle by taking the driving spindle as an axis while rotating the third gear, namely the first disc is driven to rotate in the revolution process of the driving spindle, the first disc drives the first lugs to revolve in the rotation process of the first disc, the sleeve seat rotates to rotate the sixth gear, the seventh gears revolve around the driving spindle by taking the driving spindle as an axis while rotating the sixth gears through the arrangement of the fourth internal gear, the second disc is rotated in the revolution process of the seventh gears, the second lugs revolve in the rotation process of the second disc, the mixture enters the discharge pipe and moves towards the first lugs by the arrangement of the conical disc and passes through the space between the adjacent two first lugs, and the third lugs are fixedly arranged on the inner wall of the discharge pipe, the mixture is sheared into small particles through the revolution of the plurality of first lugs and the revolution of the third lugs, the mixture penetrates through the two adjacent second lugs after being sheared, the mixture is sheared into smaller particles again through the revolution of the plurality of second lugs and the revolution of the fourth lugs, and the mixture particles meeting the requirements pass through the two adjacent fourth lugs to complete the grinding treatment on the mixture of the cistanche, the wolfberry fruit, the prepared rehmannia root, the codonopsis pilosula, the Chinese yam and the common curculigo rhizome; the force of the mixture to the second lug is set through the fifth inclined plane and the sixth inclined plane on the first lug, the mixture can rapidly pass between two adjacent third lugs, the mixture can be prevented from being blocked between two adjacent first lugs through the arrangement of the fifth inclined plane and the sixth inclined plane, similarly, the arrangement of the seventh inclined plane and the eighth inclined plane can realize that the rotation speed of the first disc is greater than that of the second disc, even if a rotation speed difference is formed in the rotation process of the first disc and the second disc, the sheared mixture can rapidly pass through, even if the mixture meeting the requirement of particles rapidly passes through, the effect of reducing is also achieved by driving the first disc to rotate through the driving main shaft, the condition that the rotation speed of the first disc is too high, the mixture can rapidly pass between two adjacent first lugs is avoided, and the mixture can move towards the plurality of first lugs through the arrangement of the conical circular plate, avoiding mixture residues; through the setting that the distance between two adjacent first lugs is greater than the distance between two adjacent second lugs, and the setting that the distance between two adjacent third lugs is greater than the distance between two adjacent fourth lugs, make the resistance that receives in reducing the mixture granule gradually to the mixture granule, a plurality of first lugs and the revolution process of second lug.
The motor is commercially available.
Example 2
The formula is as follows: 10 g of cistanche, 10 g of medlar, 15g of epimedium, 30 g of prepared rehmannia root, 20g of dodder, 10 g of codonopsis pilosula, 15g of Chinese yam, 15g of curculigo orchioides, 25 g of human placenta and 30 g of deerhorn glue.
The preparation method comprises the following steps:
step a: putting the cistanche, the wolfberry fruit, the prepared rehmannia root, the codonopsis pilosula, the common yam rhizome and the curculigo orchioides into grinding equipment according to the mass ratio, uniformly mixing, grinding into coarse powder of 40 meshes, immersing into 0.9% physiological saline for 5 minutes to form a yin-yang state with a wet surface and a dry interior, and drying for 48 hours at 30 ℃ to obtain prefabricated coarse powder for later use;
step b: mixing herba Epimedii and semen Cuscutae, soaking in 250 g of 40 deg.C water for 5 hr, decocting with slow fire for 40 min, collecting the filtrate, adding the coarse powder obtained in step (1) into the filtrate, and concentrating to obtain fluid extract to obtain premixed solution I;
step c: pulverizing placenta hominis into 200 mesh fine powder, adding into colla Cornus Cervi, spraying 10 g yellow wine, stirring, and sealing for 72 hr to obtain premix II;
step d: mixing the premix solution I and the premix solution II, adding maltodextrin and starch, spray drying to obtain powder (with drug content of 50 wt.%), stirring, and administering 50g per day.
The above-described structure of the polishing apparatus is the same as that in embodiment 1.
Example 3
The formula is as follows: 15g of cistanche, 15g of wolfberry fruit, 20g of epimedium, 30 g of prepared rehmannia root, 25 g of dodder, 20g of codonopsis pilosula, 20g of common yam rhizome, 20g of common curculigo rhizome, 25 g of human placenta and 30 g of deerhorn glue.
The preparation method comprises the following steps:
step a: putting the cistanche, the wolfberry fruit, the prepared rehmannia root, the codonopsis pilosula, the common yam rhizome and the rhizoma curculiginis into grinding equipment according to the mass ratio, uniformly mixing, grinding into coarse powder of 40 meshes, spraying 0.9% of physiological saline water on the coarse powder for 7 minutes to enable the coarse powder to be in a yin-yang state with dry exterior and interior, placing the coarse powder in a ventilated and cool place, and naturally drying for 72 hours to obtain prefabricated coarse powder for later use;
step b: mixing herba Epimedii and semen Cuscutae, soaking in 300 g of 50 deg.C water for 5 hr, decocting with slow fire for 40 min, splicing the residues to obtain filtrate, adding the coarse powder obtained in step (1) into the filtrate, and concentrating to obtain fluid extract to obtain premixed solution I;
step c: pulverizing placenta hominis into 200 mesh fine powder, adding into colla Cornus Cervi, spraying 5g yellow wine, stirring, and sealing for 72 hr to obtain premix II;
step d: mixing the premix I and the premix II, adding sucrose, maltodextrin and starch, and making into paste by conventional process.
The above-described structure of the polishing apparatus is the same as that in embodiment 1.
Example 4
The formula is as follows: 20g of cistanche, 20g of wolfberry fruit, 20g of epimedium, 35 g of prepared rehmannia root, 35 g of dodder, 20g of codonopsis pilosula, 30 g of common yam rhizome, 25 g of common curculigo rhizome, 25 g of human placenta and 25 g of deerhorn glue.
The preparation method comprises the following steps:
step a: putting the cistanche, the wolfberry fruit, the prepared rehmannia root, the codonopsis pilosula, the common yam rhizome and the rhizoma curculiginis into grinding equipment according to the mass ratio, uniformly mixing, grinding into coarse powder of 40 meshes, spraying 0.9% of physiological saline water on the coarse powder for 8 minutes to enable the coarse powder to be in a yin-yang state with dry exterior and interior, placing the coarse powder in a ventilated and cool place, and naturally drying for 72 hours to obtain prefabricated coarse powder for later use;
mixing the epimedium and the dodder, soaking for 6 hours in 300 g of water, decocting for 50 minutes with slow fire, splicing dregs to obtain filtrate, adding the prefabricated coarse powder obtained in the step (1) into the filtrate, and concentrating into a condensed fluid extract to obtain a premixed solution I;
step c: pulverizing placenta hominis into 200 mesh fine powder, adding into colla Cornus Cervi, spraying 5g yellow wine, stirring, and sealing for 60 hr to obtain premix II;
step d: mixing the premix I and the premix II, adding sucrose and maltodextrin, and making into 20 g/pill by conventional method.
The above-described structure of the polishing apparatus is the same as that in embodiment 1.
Through clinical practical accumulation and investigation on 1000 cases of male with infertility caused by kidney deficiency, low sperm count, low sperm survival rate or insufficient sperm motility, the traditional Chinese medicine pills prepared by the method provided by the invention have obvious effect in each embodiment, such as example 4, one pill (20g) in the morning and afternoon every day, and the pills are taken with warm water. It should be noted that, because the Chinese medicine belongs to yang-supporting food, it should be avoided to eat during cold and fever, and pregnant women, women in menstrual period and people under 16 years of age should take with caution.
After the patient takes the medicine continuously for one month, the results of the examination are shown in the following table 1, compared with those before the treatment:
TABLE 1 comparison of Pre-and post-treatment Effect
Figure BDA0002897740110000131
In the table, the number of the sperms is defined as less than 2 million/M, the sperm motility rating is that the sperms move rapidly and linearly forward, the straight line movement is more than or equal to 25 percent, or the sum of the slow movement and the rapid linear forward is more than or equal to 50 percent, the sperm motility is normal, the rest is abnormal, the comparative data show that the effective rate reaches 97 percent for the patient with less sperms, and the proportion of the sperms cured to the normal number is as high as 76 percent; for patients with low sperm survival rate, the survival rate of the patients after treatment reaches more than 95 percent and accounts for 78 percent, the survival rate of the patients reaches more than 90 percent and accounts for 92 percent cumulatively, the survival rate of the patients reaches more than 85 percent and accounts for 95 percent cumulatively, and the total effective rate is as high as 99 percent. For patients with low sperm motility, the significant efficiency is as high as 94 percent, and the cure rate is as high as 86 percent. After the medicine is continuously taken for 2 months, 302 cases of the medicine successfully enable women to conceive, and tracking statistics shows that more than 70% of women can produce healthy male infants after delivery. The traditional Chinese medicine preparation provided by the invention has the effects of nutrition and health care, liver and kidney nourishing and yin and yang regulating, can obviously improve the number, survival rate and vitality of male sperms, and more unexpectedly has the effects of improving the yang qi of male sperms (Y type) in semen, obviously helping the production and the energy of the male sperms (Y type), and being beneficial to the inoculation of healthy male fetuses. Furthermore, western medical clinical biochemical and imaging tests are respectively carried out on the conditioning objects before and after conditioning, and front and back comparison is carried out, so that no obvious adverse effect on main organs such as heart, liver, spleen, lung, kidney and the like is seen. In conclusion, the traditional Chinese medicine preparation has nourishing and regulating effects on the male in the later breeding period, is safe and has no side effect.

Claims (6)

1. A preparation method of a tonic traditional Chinese medicine preparation for male fertility is characterized by comprising the following steps: the traditional Chinese medicine preparation comprises the following raw materials in parts by mass: 3-50 parts of cistanche, 3-50 parts of wolfberry fruit, 5-60 parts of epimedium, 5-100 parts of prepared rehmannia root, 5-100 parts of dodder, 3-50 parts of codonopsis pilosula, 3-55 parts of Chinese yam, 3-55 parts of curculigo orchioides, 3-55 parts of human placenta and 5-65 parts of deerhorn glue;
the preparation method of the traditional Chinese medicine preparation comprises the following steps:
step a: putting the cistanche, the wolfberry fruit, the prepared rehmannia root, the codonopsis pilosula, the common yam rhizome and the curculigo orchioides into grinding equipment according to the mass ratio, uniformly mixing, grinding into 20-40 meshes of coarse powder, immersing or spraying normal saline for 5-8 minutes, and drying to obtain prefabricated coarse powder;
step b: b, mixing the epimedium herb and the dodder, soaking the mixture in water which is 5-10 times of the total mass of the mixture for more than 4 hours, decocting the mixture for 40-60 minutes with slow fire, taking filtrate, adding the prepared coarse powder obtained in the step a into the filtrate, and concentrating the filtrate to obtain a premixed solution I;
step c: pulverizing placenta hominis into fine powder, adding into colla cornus cervi, spraying yellow wine, stirring, sealing for 48-100 hr to obtain premixed solution II;
step d: mixing the premixed solution I and the premixed solution II, and preparing a traditional Chinese medicine preparation by auxiliary materials, wherein the traditional Chinese medicine preparation is a pill, a pellet, an ointment or powder;
the grinding equipment in the step a comprises a machine body (1), a grinding barrel (2) fixedly arranged on the machine body, a first grinding device (3) arranged in the grinding barrel, a filling device (4) arranged on the grinding barrel and used for adding cistanche, wolfberry fruit, prepared rehmannia root, codonopsis pilosula, common yam rhizome and rhizoma curculiginis, a discharge pipe (5) fixedly arranged at the bottom of the grinding barrel, and a second grinding device (6) arranged in the discharge pipe, wherein the first grinding device (3) comprises a driving main shaft (31), an eccentric shaft (32) fixedly arranged on the driving main shaft, a grinding roller (33) rotatably sleeved on the eccentric shaft, a cavity (34) arranged in the grinding roller, a plurality of first grooves (35) annularly distributed on the grinding roller at equal intervals, a first through hole (36) arranged on the grinding roller and used for communicating the cavity with the first grooves, a plurality of first push plates (37) respectively movably arranged in the first grooves, The grinding machine comprises a plurality of first guide rods (38), a volute plate (39), a conical surface (310), a first gear (311), a first internal gear (312), a motor (313), a circular plate (314) and a plurality of blanking ports (315), wherein one end of each first guide rod is fixedly arranged on a first push plate, the other end of each first guide rod is movably inserted into a grinding roller, the volute plate is fixedly sleeved on a driving main shaft, the conical surface (310) is arranged on the grinding roller, the first gear (311) is fixedly arranged on the grinding roller, the first internal gear (312) is fixedly arranged on a grinding barrel and matched with the first gear, the motor (313) is fixedly arranged on a machine body and used; the blanking port gradually becomes wider from outside to inside; the vortex plate is positioned between the bottom of the grinding barrel and the bottom of the grinding roller; firstly, continuously adding cistanche, wolfberry fruit, prepared rehmannia root, codonopsis pilosula, common yam rhizome and common curculigo rhizome into a filling device, driving a driving main shaft to rotate through the driving of a motor, driving the whole filling device to operate, uniformly stirring the cistanche, the wolfberry fruit, the prepared rehmannia root, the codonopsis pilosula, the common yam rhizome and the common curculigo rhizome in the filling device, uniformly putting the mixture between a grinding roller and a grinding barrel, driving the driving main shaft to rotate through the driving of the motor, driving an eccentric shaft to rotate by the rotation of the driving main shaft, driving the grinding roller to rotate by taking the driving main shaft as an axis, driving the grinding roller to roll on the inner wall of the grinding barrel by the eccentric shaft through the arrangement of a first gear and a first inner gear, grinding the mixture of the cistanche, the wolfberry fruit, the prepared rehmannia root, the codonopsis pilosula, the common yam rhizome and the common curculigo rhizome by the first gear along the first, move to the plectane direction promptly, get into in the discharge tube through a plurality of blanking mouths at last, the drive main shaft drives the second grinder and grinds the mixture in the discharge tube once more, accomplishes and mixes and grinds cistanche salsa, the fruit of Chinese wolfberry, prepared rehmannia root, radix codonopsitis, huai-shan yam and curculigo rhizome.
2. The preparation method of the nourishing traditional Chinese medicine preparation for male fertility according to claim 1, is characterized in that: in the step b, the epimedium and the dodder are mixed, soaked for more than 6 hours at 20-40 ℃ by using water with the total mass being 6-8 times of that of the epimedium and the dodder, and the obtained premixed liquid I is a fluid extract.
3. The preparation method of the nourishing traditional Chinese medicine preparation for male fertility according to claim 1, is characterized in that: the grinding barrel (2) comprises a barrel body (21), a plurality of second grooves (22) which are distributed on the inner wall of the barrel body in an equidistant annular mode, a plurality of second push plates (23) which are respectively and movably arranged in the plurality of second grooves, a plurality of connecting cavities (24) which are fixedly arranged on the machine body in a one-to-one correspondence mode with the plurality of second grooves, a plurality of sleeves (25) of which two ends are respectively and fixedly arranged on the connecting cavities and the barrel body, a first push rod (26) which is movably arranged in one of the sleeves and one end of which is attached to the first gear, a plurality of second push rods (27) which are respectively and movably arranged in the other sleeves and of which one end is fixedly arranged on the second push plates, and a spring (28) which is sleeved on the first push rod and of which two ends are respectively and fixedly arranged on the; first gear rotates the in-process along first internal gear and promotes first push rod in a plurality of sleeves in proper order and removes to connecting the chamber direction, connects intracavity space and diminishes, and a plurality of second push rods of drive are kept away from and are connected the chamber, promote the second push pedal promptly and remove to the middle department in the staving, and the second push pedal inboard and staving inner wall coincidence reset first push rod through the spring, reset the second push pedal promptly.
4. The preparation method of the nourishing traditional Chinese medicine preparation for male fertility according to claim 1, is characterized in that: the filling device (4) comprises a stirring barrel (41), a plurality of first feeding pipes (42) which are respectively fixedly arranged on the stirring barrel and the barrel body at two ends in an equidistant annular distribution and are used for being communicated with each other, a rotary disc (43) which is rotatably sleeved on a driving main shaft and is rotatably arranged on the inner wall of the stirring barrel, a plurality of second feeding pipes (44) which are respectively arranged on the rotary disc in an equidistant annular distribution and penetrate through the rotary disc, a second gear (45) fixedly sleeved on the driving main shaft, a plurality of third gears (46) which are respectively fixedly sleeved on the plurality of second feeding pipes and are meshed with the second gears, a second inner gear (47) which is fixedly arranged on the stirring barrel and is meshed with the plurality of third gears, and a plurality of stirring blades (48) which are fixedly arranged on the; cistanche, wolfberry fruit, prepared rehmannia root, dangshen, common yam rhizome and common curculigo rhizome are in one-to-one correspondence with a plurality of second feeding pipes, namely, the cistanche, the wolfberry fruit, the prepared rehmannia root, the dangshen, the common yam rhizome and the common curculigo rhizome are added into the stirring barrel through the plurality of second feeding pipes, the driving spindle drives the second gear to rotate in the rotating process, the second gear drives the third gear to rotate in the rotating process, the third gear drives the third gear to revolve around the driving spindle as the axis and to self-transmit, the third gear drives the second feeding pipes to rotate in the self-transmitting process, the stirring blades are driven to rotate in the rotating process of the second feeding pipes, namely, the stirring blades revolve around the driving spindle as the axis in the self-transmitting process, the cistanche, the wolfberry fruit, the prepared rehmannia root, the dangshen, the common yam rhizome and the curculigo rhizome are mixed and.
5. The preparation method of the nourishing traditional Chinese medicine preparation for male fertility according to claim 4, is characterized in that: the stirring blade (48) comprises a blade body (481), a first inclined surface (482), a second inclined surface (483), a third inclined surface (484), a fourth inclined surface (485) which are arranged on the blade body, a plurality of first guide chutes (486) which are obliquely arranged on the blade body at equal intervals, and a plurality of second guide chutes (487) which are staggered with the plurality of first guide chutes, wherein the inclination angles of the first guide chutes and the second guide chutes are opposite; set up through first inclined plane to fourth inclined plane and keep away from the second charge tube direction to cistanche deserticola in the agitator, the wolfberry fruit, the preparation of rehmannia, the codonopsis pilosula, it removes to say that chinese yam and curculigo orchioides, carry out the water conservancy diversion through cistanche deserticola in first baffle box and the second baffle box to the agitator, the wolfberry fruit, the preparation of rehmannia, the codonopsis pilosula, it carries out the water conservancy diversion to say that chinese yam and curculigo orchioides, the blade body rotates the in-process promptly and stirs the limit and keeps away from the blade body simultaneously to cistanche deserticola, the wolfberry fruit.
6. The preparation method of the nourishing traditional Chinese medicine preparation for male fertility according to claim 1, is characterized in that: the second grinding device (6) comprises a fixed disc (61) which is sleeved on the driving main shaft in a rotating mode, an inserting rod (62) which is arranged on the fixed disc and the discharging pipe in a penetrating mode, a third internal gear (63) which is fixedly arranged on the fixed disc, a fourth gear (64) which is fixedly sleeved on the driving main shaft, a first disc (65) which is sleeved on the driving main shaft in a rotating mode, a plurality of fifth gears (66) which are arranged on the first disc in an equidistant annular distribution mode and are respectively meshed with the fourth gear and the third internal gear, a sleeve seat (67) which is arranged on the fixed disc in a rotating mode and is fixedly arranged on the first disc, a fourth internal gear (68) which is fixedly sleeved on the fixed disc, a sixth gear (69) which is fixedly sleeved on the sleeve seat, a second disc (610) which is arranged on the sleeve seat in a rotating mode, a plurality of seventh gears (611) which are arranged on the second disc, A plurality of first lugs (612) which are distributed and fixed on the first disc in an equidistant annular manner, a plurality of second lugs (613) which are distributed and fixed on the second disc in an equidistant annular manner, a plurality of third lugs (614) and a plurality of fourth lugs (615) which are distributed and fixed on the inner wall of the discharge pipe in an equidistant annular manner, and a conical round plate (621) which is fixed on the first disc and is rotationally sleeved on the driving main shaft; the first bump and the second bump are identical in structure, the first bump comprises a first body (616), a first arc-shaped surface (617) arranged on the first body, a fifth inclined surface (618) and a sixth inclined surface (619) arranged on the first body, and the first arc-shaped surface is attached to the inner wall of the discharge pipe; the third bump and the fourth bump have the same structure, the third bump comprises a second body (620), a second arc-shaped surface arranged on the second body, a seventh inclined surface (622) and an eighth inclined surface (623) arranged on the second body, the second arc-shaped surface on the third bump is attached to the sleeve seat, and the second arc-shaped surface on the fourth bump is attached to the fourth inner gear; the distance between two adjacent first lugs is greater than the distance between two adjacent second lugs; the distance between two adjacent third bumps is greater than the distance between two adjacent fourth bumps; the fourth gear is driven to rotate in the rotation process of the driving main shaft, the fourth gear is driven to rotate by the third internal gear to drive the fifth gears to revolve with the driving main shaft as an axis, the first disc is driven to rotate in the revolution process of the driving main shaft, the first lugs are driven to revolve in the rotation process of the first disc, the sleeve seat is driven to rotate by the rotation of the first disc, the sixth gear is driven to rotate by the rotation of the sleeve seat, the seventh gears are driven to revolve with the driving main shaft as an axis in the rotation process of the sixth gear by the fourth internal gear, the second disc is driven to rotate in the revolution process of the seventh gears, the second lugs are driven to revolve in the rotation process of the second disc, the mixture enters the discharge pipe and moves towards the first lugs by the arrangement of the conical circular plate and passes through the space between two adjacent first lugs, and the mixture is sheared into small particles by the arrangement of the first lugs and the third lugs, after the mixture is sheared, the mixture penetrates through the two adjacent second lugs, the mixture is sheared into smaller particles again through the revolution of the plurality of second lugs and the fourth lugs, the mixture particles meeting the requirements pass through the two adjacent fourth lugs, and the mixture of the cistanche, the wolfberry fruit, the prepared rehmannia root, the codonopsis pilosula, the common yam rhizome and the common curculigo rhizome is ground again.
CN202110047131.5A 2021-01-14 2021-01-14 Preparation method of male fertility-preparing nourishing traditional Chinese medicine preparation Pending CN112618645A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107184771A (en) * 2017-07-26 2017-09-22 臧星 A kind of Chinese medicine for nourishing regulation for the phase of educating for male and preparation method thereof
CN108097405A (en) * 2017-12-15 2018-06-01 郑州仁宏医药科技有限公司 A kind of multiple milling apparatus of Chinese medicine
CN110947495A (en) * 2019-12-04 2020-04-03 杭州更蓝生物科技有限公司 Add granular raw materials processing equipment of cosmetics of herbaceous plant

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107184771A (en) * 2017-07-26 2017-09-22 臧星 A kind of Chinese medicine for nourishing regulation for the phase of educating for male and preparation method thereof
CN108097405A (en) * 2017-12-15 2018-06-01 郑州仁宏医药科技有限公司 A kind of multiple milling apparatus of Chinese medicine
CN110947495A (en) * 2019-12-04 2020-04-03 杭州更蓝生物科技有限公司 Add granular raw materials processing equipment of cosmetics of herbaceous plant

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