CN112585268B - 通过插入供体多核苷酸用于基因组编辑的组合物和方法 - Google Patents

通过插入供体多核苷酸用于基因组编辑的组合物和方法 Download PDF

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CN112585268B
CN112585268B CN201980056488.0A CN201980056488A CN112585268B CN 112585268 B CN112585268 B CN 112585268B CN 201980056488 A CN201980056488 A CN 201980056488A CN 112585268 B CN112585268 B CN 112585268B
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donor polynucleotide
mutation
nucleotides
sequence
gdna
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CN112585268A (zh
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T·D·卡洛
R·L·博戈拉德
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CRISPR Therapeutics AG
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    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
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    • C12N2800/00—Nucleic acids vectors
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CN201980056488.0A 2018-06-28 2019-06-28 通过插入供体多核苷酸用于基因组编辑的组合物和方法 Active CN112585268B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862691573P 2018-06-28 2018-06-28
US62/691573 2018-06-28
PCT/IB2019/000833 WO2020003006A2 (en) 2018-06-28 2019-06-28 Compositions and methods for genomic editing by insertion of donor polynucleotides

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CN112585268A CN112585268A (zh) 2021-03-30
CN112585268B true CN112585268B (zh) 2025-03-04

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US (3) US11827877B2 (https=)
EP (1) EP3814499A2 (https=)
JP (1) JP7550057B2 (https=)
KR (1) KR20210027389A (https=)
CN (1) CN112585268B (https=)
AU (1) AU2019293286A1 (https=)
BR (1) BR112020025824A2 (https=)
CA (1) CA3104028A1 (https=)
IL (1) IL279718A (https=)
MX (1) MX2020014248A (https=)
SG (1) SG11202012499RA (https=)
WO (1) WO2020003006A2 (https=)

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US11866726B2 (en) 2017-07-14 2024-01-09 Editas Medicine, Inc. Systems and methods for targeted integration and genome editing and detection thereof using integrated priming sites
AU2019293286A1 (en) 2018-06-28 2021-01-07 Crispr Therapeutics Ag Compositions and methods for genomic editing by insertion of donor polynucleotides
SG11202103917VA (en) * 2018-10-16 2021-05-28 Blueallele Llc Methods for targeted insertion of dna in genes
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US12521451B2 (en) 2019-11-08 2026-01-13 Regeneron Pharmaceuticals, Inc. CRISPR and AAV strategies for x-linked juvenile retinoschisis therapy
US20220056437A1 (en) * 2020-08-19 2022-02-24 Integrated Dna Technologies, Inc. Methods and compositions for inhibition of crispr re-cleavage events
US20240368587A1 (en) * 2021-04-01 2024-11-07 Duke University Compositions For and Methods of Editing the Genome
CN113403309B (zh) * 2021-05-24 2022-08-16 珠海舒桐医疗科技有限公司 非同源双链寡聚核苷酸片段在基因敲除系统中的应用
CN113416730B (zh) * 2021-07-07 2023-04-04 中国医学科学院血液病医院(中国医学科学院血液学研究所) 一种降低细胞因基因编辑产生的大片段删除突变的方法
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CN114686440B (zh) * 2022-05-31 2022-09-27 南京艾尔普再生医学科技有限公司 一种低免疫原性iPSC细胞的制备方法、低免疫原性iPSC细胞及组合物
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