CN112585139B - 用作t细胞激活剂的萘啶酮化合物 - Google Patents

用作t细胞激活剂的萘啶酮化合物 Download PDF

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Publication number
CN112585139B
CN112585139B CN201980055153.7A CN201980055153A CN112585139B CN 112585139 B CN112585139 B CN 112585139B CN 201980055153 A CN201980055153 A CN 201980055153A CN 112585139 B CN112585139 B CN 112585139B
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Prior art keywords
methyl
piperazin
dihydro
oxo
naphthyridine
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Chinese (zh)
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CN112585139A (zh
Inventor
L·S·丘帕克
丁敏
R·G·詹特尔斯
黄雅忠
S·W·马丁
I·M·麦克唐纳
S·E·默瑟
R·E·奥尔森
U·维拉帕蒂
M·威罗斯基
郑晓帆
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201980055153.7A 2018-06-27 2019-06-26 用作t细胞激活剂的萘啶酮化合物 Active CN112585139B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862690444P 2018-06-27 2018-06-27
US62/690,444 2018-06-27
PCT/US2019/039131 WO2020006016A1 (en) 2018-06-27 2019-06-26 Naphthyridinone compounds useful as t cell activators

Publications (2)

Publication Number Publication Date
CN112585139A CN112585139A (zh) 2021-03-30
CN112585139B true CN112585139B (zh) 2023-12-01

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SM (1) SMT202300170T1 (enExample)
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HRP20230627T1 (hr) 2023-09-29
KR20210024587A (ko) 2021-03-05
IL279730B2 (en) 2023-12-01
IL279730B1 (en) 2023-08-01
AU2019291792A1 (en) 2021-02-11
AU2019291792B2 (en) 2022-09-29
KR102804324B1 (ko) 2025-05-08
WO2020006016A1 (en) 2020-01-02
JP7373512B2 (ja) 2023-11-02
US20210277004A1 (en) 2021-09-09
ES2950007T3 (es) 2023-10-04
MX2020013373A (es) 2021-03-09
HUE062412T2 (hu) 2023-10-28
CY1126179T1 (el) 2026-02-25
US11866430B2 (en) 2024-01-09
RS64285B1 (sr) 2023-07-31
EA202190137A1 (ru) 2021-05-17
BR112020026568A2 (pt) 2021-03-23
PT3814347T (pt) 2023-07-18
SMT202300170T1 (it) 2023-09-06
SG11202012973RA (en) 2021-01-28
PL3814347T3 (pl) 2023-07-24
SI3814347T1 (sl) 2023-07-31
LT3814347T (lt) 2023-07-10
EP3814347A1 (en) 2021-05-05
DK3814347T3 (da) 2023-08-07
IL279730A (en) 2021-03-01
CN112585139A (zh) 2021-03-30
FI3814347T3 (fi) 2023-06-12
JP2021528469A (ja) 2021-10-21
CA3104647A1 (en) 2020-01-02
EP3814347B1 (en) 2023-05-03

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