CA3104647A1 - Naphthyridinone compounds useful as t cell activators - Google Patents

Naphthyridinone compounds useful as t cell activators Download PDF

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Publication number
CA3104647A1
CA3104647A1 CA3104647A CA3104647A CA3104647A1 CA 3104647 A1 CA3104647 A1 CA 3104647A1 CA 3104647 A CA3104647 A CA 3104647A CA 3104647 A CA3104647 A CA 3104647A CA 3104647 A1 CA3104647 A1 CA 3104647A1
Authority
CA
Canada
Prior art keywords
methyl
oxo
dihydro
naphthyridine
piperazin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3104647A
Other languages
English (en)
French (fr)
Inventor
Louis S. Chupak
Min Ding
Robert G. Gentles
Yazhong Huang
Scott W. Martin
Ivar M. Mcdonald
Stephen E. Mercer
Richard E. Olson
Upender Velaparthi
Michael WICHROSKI
Xiaofan Zheng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of CA3104647A1 publication Critical patent/CA3104647A1/en
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA3104647A 2018-06-27 2019-06-26 Naphthyridinone compounds useful as t cell activators Pending CA3104647A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862690444P 2018-06-27 2018-06-27
US62/690,444 2018-06-27
PCT/US2019/039131 WO2020006016A1 (en) 2018-06-27 2019-06-26 Naphthyridinone compounds useful as t cell activators

Publications (1)

Publication Number Publication Date
CA3104647A1 true CA3104647A1 (en) 2020-01-02

Family

ID=67297314

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3104647A Pending CA3104647A1 (en) 2018-06-27 2019-06-26 Naphthyridinone compounds useful as t cell activators

Country Status (25)

Country Link
US (1) US11866430B2 (enExample)
EP (1) EP3814347B1 (enExample)
JP (1) JP7373512B2 (enExample)
KR (1) KR102804324B1 (enExample)
CN (1) CN112585139B (enExample)
AU (1) AU2019291792B2 (enExample)
BR (1) BR112020026568A2 (enExample)
CA (1) CA3104647A1 (enExample)
CY (1) CY1126179T1 (enExample)
DK (1) DK3814347T3 (enExample)
EA (1) EA202190137A1 (enExample)
ES (1) ES2950007T3 (enExample)
FI (1) FI3814347T3 (enExample)
HR (1) HRP20230627T1 (enExample)
HU (1) HUE062412T2 (enExample)
IL (1) IL279730B2 (enExample)
LT (1) LT3814347T (enExample)
MX (1) MX2020013373A (enExample)
PL (1) PL3814347T3 (enExample)
PT (1) PT3814347T (enExample)
RS (1) RS64285B1 (enExample)
SG (1) SG11202012973RA (enExample)
SI (1) SI3814347T1 (enExample)
SM (1) SMT202300170T1 (enExample)
WO (1) WO2020006016A1 (enExample)

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CA3162979A1 (en) * 2019-12-23 2021-07-01 Upender Velaparthi Substituted piperazine derivatives useful as t cell activators
BR112022012179A2 (pt) 2019-12-23 2022-09-06 Bristol Myers Squibb Co Compostos de quinazolina substituída úteis como ativadores de célula t
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Also Published As

Publication number Publication date
SG11202012973RA (en) 2021-01-28
SMT202300170T1 (it) 2023-09-06
US11866430B2 (en) 2024-01-09
HUE062412T2 (hu) 2023-10-28
IL279730A (en) 2021-03-01
US20210277004A1 (en) 2021-09-09
AU2019291792A1 (en) 2021-02-11
MX2020013373A (es) 2021-03-09
WO2020006016A1 (en) 2020-01-02
CN112585139B (zh) 2023-12-01
JP2021528469A (ja) 2021-10-21
KR102804324B1 (ko) 2025-05-08
SI3814347T1 (sl) 2023-07-31
IL279730B1 (en) 2023-08-01
PL3814347T3 (pl) 2023-07-24
BR112020026568A2 (pt) 2021-03-23
RS64285B1 (sr) 2023-07-31
DK3814347T3 (da) 2023-08-07
IL279730B2 (en) 2023-12-01
HRP20230627T1 (hr) 2023-09-29
CY1126179T1 (el) 2026-02-25
EA202190137A1 (ru) 2021-05-17
AU2019291792B2 (en) 2022-09-29
CN112585139A (zh) 2021-03-30
JP7373512B2 (ja) 2023-11-02
ES2950007T3 (es) 2023-10-04
EP3814347A1 (en) 2021-05-05
PT3814347T (pt) 2023-07-18
FI3814347T3 (fi) 2023-06-12
EP3814347B1 (en) 2023-05-03
LT3814347T (lt) 2023-07-10
KR20210024587A (ko) 2021-03-05

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