CN112569410A - Lubricating mucilage for enteroscope detection - Google Patents

Abstract

The invention discloses lubricating mucilage for enteroscope detection, which comprises the following components in parts by weight: 1-3 parts of carbomer, 0.5-0.8 part of propylene glycol, 0.2-0.6 part of sodium hydroxide, 2-6 parts of lidocaine hydrochloride, 0.4-0.8 part of sodium carboxymethylcellulose, 0.2-0.6 part of chitosan, 1-4 parts of simethicone, 6-14 parts of glycerol, 0.06-0.16 part of L-menthol, 0.3-0.9 part of glacial acetic acid, 0.01-0.03 part of chymotrypsin, 0.05-0.1 part of sodium bicarbonate powder and 80-90 parts of purified water. The lubricating mucilage is prepared from lidocaine hydrochloride, sodium carboxymethylcellulose, chitosan, simethicone, glycerol, L-menthol, glacial acetic acid, chymotrypsin, sodium bicarbonate powder and purified water, an oily film can be formed in the oral cavity of an esophagus by adding the glycerol, friction is reduced, a lubricating effect is further achieved, local anesthesia can be caused to the oral cavity and the esophagus after the lubricating mucilage is taken, stimulation is reduced, and examination and operation reactions are reduced.

Description

Lubricating mucilage for enteroscope detection

Technical Field

The invention belongs to the technical field of gastroscopes, and particularly relates to lubricating mucilage for enteroscope detection.

Background

Gastroscopy is a slender tube with a black plastic coated with light-conducting fiber, and the front end of the slender tube is provided with an endoscope which is inserted into the esophagus → stomach → duodenum of the examined person from the mouth.

The existing lubricating mucilage for enteroscopy also has some problems: during enteroscope detection, bubbles are easily generated, the visual field is blurred, the observation effect is reduced, and meanwhile, during enteroscope detection, the detection and operation reaction is large, so that the lubricating mucilage for enteroscope detection is provided.

Disclosure of Invention

The invention aims to provide lubricating cement for enteroscope detection, which solves the problems in the background technology.

In order to achieve the purpose, the invention provides the following technical scheme: the lubricating mucilage for enteroscope detection comprises the following components in parts by weight: 1-3 parts of carbomer, 0.5-0.8 part of propylene glycol, 0.2-0.6 part of sodium hydroxide, 2-6 parts of lidocaine hydrochloride, 0.4-0.8 part of sodium carboxymethylcellulose, 0.2-0.6 part of chitosan, 1-4 parts of simethicone, 6-14 parts of glycerol, 0.06-0.16 part of L-menthol, 0.3-0.9 part of glacial acetic acid, 0.01-0.03 part of chymotrypsin, 0.05-0.1 part of sodium bicarbonate powder and 80-90 parts of purified water.

Preferably, the composition comprises the following components in parts by weight: 2 parts of carbomer, 0.6 part of propylene glycol, 0.3 part of sodium hydroxide, 4 parts of lidocaine hydrochloride, 0.6 part of sodium carboxymethylcellulose, 0.4 part of chitosan, 3 parts of simethicone, 10 parts of glycerol, 0.12 part of L-menthol, 0.6 part of glacial acetic acid, 0.02 part of chymotrypsin, 0.08 part of sodium bicarbonate powder and 85 parts of purified water.

Preferably, the preparation method of the lidocaine hydrochloride comprises the following steps:

s1, sequentially adding sodium methoxide, 2, 6-dimethylaniline and N, N-diethylaminoacetic acid methyl ester into a reaction vessel, heating to 88-98 ℃, distilling while reacting to remove methanol generated in the reaction until no methanol is evaporated, continuing to react for 30-40min, and cooling to room temperature;

s2, adding dichloroethane, washing with water, standing and layering to obtain an organic layer, namely a dichloroethane solution of lidocaine base;

s3, adding hydrochloric acid into a dichloroethane solution of lidocaine base, adjusting the pH to 3-5 with hydrogen chloride, adding activated carbon, refluxing for 20-45min, filtering, concentrating the filtrate, cooling, crystallizing, and drying to obtain lidocaine hydrochloride.

Preferably, the preparation method of the 2, 6-dimethylaniline comprises the following steps:

s1, sequentially adding 2, 6-xylenol, ammonia water, Pd/C and 2, 6-dimethylcyclohexanone into a reaction vessel, reacting for 4-9h at the temperature of 170-200 ℃, cooling to room temperature, filtering, and recovering Pd/C for reuse;

s2, distilling the filtrate under reduced pressure, recovering 2, 6-dimethylcyclohexanone for the next use, washing residues with water, standing and layering to obtain an oil layer, namely the 2, 6-dimethylaniline.

Preferably, the preparation method of the simethicone comprises the following steps:

s1, crushing, cleaning and drying waste high-temperature silicon vulcanized rubber;

s2, adding 70-130 parts by weight of crushed high-temperature silicon vulcanized rubber, 1-4 parts by weight of tetramethylammonium chloride and 240 parts by weight of butanone into a first reaction kettle with a vent pipe at the bottom, heating to 90-110 ℃, stirring for reaction for 0.5-1 hour, opening the vent pipe valve at the bottom of the first reaction kettle, continuously introducing nitrogen for bubbling, vacuumizing the reaction kettle to maintain the vacuum degree at 0.2-0.8 MPa for 4-6 hours, and continuously extracting volatile gas;

s3, condensing the extracted gas, introducing the condensed gas into a second reaction kettle, vacuumizing to-0.08 MPa-0MPa for dehydration at 60-90 ℃, adding tetramethylammonium hydroxide with a catalyst amount, heating to 110-phase and 115 ℃, preserving the temperature for 0.5-2 hours, adding a sealing agent, and heating to 120-phase and 130 ℃ for reaction for 1-3 hours;

s4, heating to 150-200 ℃, breaking the catalyst for 3-4 hours, heating to 200-240 ℃, opening a vent pipe valve at the bottom of the second reaction kettle, continuously introducing nitrogen into the second reaction kettle under the stirring condition for bubbling, vacuumizing the reaction kettle to maintain the vacuum degree at 0.04-0.2MPa for 1-4 hours, and continuously extracting volatilized gas, wherein the liquid in the second reaction kettle is the dimethyl silicon oil.

Preferably, the high-temperature silicon vulcanized rubber in the S1 is crushed into 10-60 meshes, and the cleaning mode in the S1 is as follows: washing with water and then butanone, wherein the drying temperature in the S1 is 40-70 ℃.

Preferably, the capping agent in S3 is hexamethyldisiloxane.

Preferably, the preparation method of the glycerol comprises the following steps:

s1, decomposing starch by double enzymes to generate glucose, and fermenting by using yeast to generate crude glycerol;

s2, decomposing the crude glycerin obtained in the step S1 at the temperature of 190-210 ℃ to volatilize a part of decomposed substances in a gas form, filtering by using a plate frame to remove a part of coked substances generated by carbonization, performing ion exchange by using an anion-cation exchange column to remove residual substances after decomposition, and finally performing vacuum concentration to form a pharmaceutical grade glycerin product.

Preferably, the preparation method of the lubricating mucilage is also included, and the preparation method of the lubricating mucilage comprises the following steps:

s1, raw material preparation: taking the following raw materials in parts by weight: 2-6 parts of lidocaine hydrochloride, 0.4-0.8 part of sodium carboxymethylcellulose, 0.2-0.6 part of chitosan, 1-4 parts of simethicone, 6-14 parts of glycerol, 0.06-0.16 part of L-menthol, 0.3-0.9 part of glacial acetic acid, 0.01-0.03 part of chymotrypsin, 0.05-0.1 part of sodium bicarbonate powder and 80-90 parts of purified water;

s2, preparing a first mixture: putting lidocaine hydrochloride in parts by weight into 20-45 parts of purified water, stirring to completely dissolve, then adding glycerol, chymotrypsin and sodium bicarbonate powder in parts by weight, and stirring uniformly to obtain a first mixture;

s3, preparing a second mixture: adding purified water into glacial acetic acid in parts by weight to prepare an acetic acid solution with the concentration of 1-3%, adding chitosan and L-menthol in parts by weight to dissolve in the acetic acid solution, then adding sodium carboxymethylcellulose in a prescribed amount, and stirring to completely swell to obtain a second mixture;

s4, preparing lubricating cement paste by mixing raw materials: and (3) uniformly mixing the first mixture in the S2 and the second mixture in the S3, adjusting the pH value to 6.0-7.0 by adopting a sodium hydroxide solution, adding the residual purified water to a sufficient amount, and uniformly mixing to obtain the lubricating mucilage.

Compared with the prior art, the invention has the beneficial effects that: the lubricating mucilage is prepared from lidocaine hydrochloride, sodium carboxymethylcellulose, chitosan, simethicone, glycerol, L-menthol, glacial acetic acid, chymotrypsin, sodium bicarbonate powder and purified water, an oily film can be formed in the oral cavity of an esophagus by adding the glycerol, friction is reduced, a lubricating effect is further achieved, bubble tension can be reduced by adding the simethicone, bubble breakage is caused, an effect of eliminating bubbles is achieved, the visual field is relatively clear, local anesthesia can be caused to the oral cavity and the esophagus after the lubricating mucilage is taken by adding the lidocaine hydrochloride local anesthetic, irritation is reduced, and inspection and operation reactions are reduced.

Drawings

FIG. 1 is a flow chart of the preparation of the lubricating cement of the present invention.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Example 1

Referring to fig. 1, the present invention provides a technical solution: the lubricating mucilage for enteroscope detection comprises the following components in parts by weight: 1 part of carbomer, 0.3 part of propylene glycol, 0.1 part of sodium hydroxide, 2 parts of lidocaine hydrochloride, 0.4 part of sodium carboxymethylcellulose, 0.2 part of chitosan, 1 part of simethicone, 6 parts of glycerol, 0.06 part of L-menthol, 0.3 part of glacial acetic acid, 0.01 part of chymotrypsin, 0.05 part of sodium bicarbonate powder and 90 parts of purified water.

In this embodiment, preferably, the preparation method of lidocaine hydrochloride includes:

s1, sequentially adding sodium methoxide, 2, 6-dimethylaniline and N, N-diethylaminoacetic acid methyl ester into a reaction vessel, heating to 88 ℃, carrying out reaction while distilling to remove methanol generated in the reaction until no methanol is evaporated, continuing to react for 30min, and cooling to room temperature;

s2, adding dichloroethane, washing with water, standing and layering to obtain an organic layer, namely a dichloroethane solution of lidocaine base;

s3, adding hydrochloric acid into a dichloroethane solution of lidocaine base, adjusting the pH to 3 by using hydrogen chloride, adding activated carbon, refluxing for 20min, filtering, concentrating the filtrate, cooling, crystallizing and drying to obtain the lidocaine hydrochloride.

In this embodiment, preferably, the preparation method of 2, 6-dimethylaniline includes the following steps:

s1, sequentially adding 2, 6-xylenol, ammonia water, Pd/C and 2, 6-dimethylcyclohexanone into a reaction vessel, reacting for 9 hours at 170 ℃, cooling to room temperature, filtering, and recovering Pd/C for reuse;

s2, distilling the filtrate under reduced pressure, recovering 2, 6-dimethylcyclohexanone for the next use, washing residues with water, standing and layering to obtain an oil layer, namely the 2, 6-dimethylaniline.

In this embodiment, preferably, the preparation method of the dimethylsilicone oil includes the following steps:

s1, crushing, cleaning and drying waste high-temperature silicon vulcanized rubber;

s2, adding 70 parts by weight of crushed high-temperature silicon vulcanized rubber, 1 part by weight of tetramethylammonium chloride and 160 parts by weight of butanone into a first reaction kettle with a vent pipe at the bottom, heating to 90 ℃, stirring for reaction for 1 hour, opening a vent pipe valve at the bottom of the first reaction kettle, continuously introducing nitrogen for bubbling, vacuumizing the reaction kettle to maintain the vacuum degree at 0.2Mpa for 4 hours, and continuously pumping out volatilized gas;

s3, condensing the extracted gas, introducing the condensed gas into a second reaction kettle, vacuumizing to-0.08 Mpa at 60-90 ℃ for dehydration, adding tetramethylammonium hydroxide with a catalytic amount, heating to 110 ℃, preserving heat for 0.5 hour, adding an end sealing agent, and heating to 120 ℃ for reaction for 1 hour;

s4, heating the temperature to 150 ℃, breaking the catalyst for 3 hours, heating the temperature to 200 ℃, opening a vent pipe valve at the bottom of the second reaction kettle, continuously introducing nitrogen into the second reaction kettle under the stirring condition for bubbling, vacuumizing the reaction kettle to maintain the vacuum degree at 0.04Mpa for 1 hour, and continuously pumping out the volatilized gas, wherein the liquid in the second reaction kettle is the dimethyl silicon oil.

In this embodiment, preferably, the high-temperature vulcanized silicone rubber in S1 is pulverized into 10 meshes, and the cleaning manner in S1 is as follows: washing with water and then butanone, wherein the drying temperature in the S1 is 40 ℃.

In this embodiment, preferably, the capping agent in S3 is hexamethyldisiloxane.

In this embodiment, preferably, the preparation method of glycerol includes the following steps:

s1, decomposing starch by double enzymes to generate glucose, and fermenting by using yeast to generate crude glycerol;

s2, decomposing the crude glycerin obtained in the step S1 at the temperature of 190-210 ℃ to volatilize a part of decomposed substances in a gas form, filtering by using a plate frame to remove a part of coked substances generated by carbonization, performing ion exchange by using an anion-cation exchange column to remove residual substances after decomposition, and finally performing vacuum concentration to form a pharmaceutical grade glycerin product.

In this embodiment, it is preferable that the method further includes a method for preparing the lubricating cement, and the method for preparing the lubricating cement includes the following steps:

s1, raw material preparation: taking the following raw materials in parts by weight: 2 parts of lidocaine hydrochloride, 0.4 part of sodium carboxymethylcellulose, 0.2 part of chitosan, 1 part of simethicone, 6 parts of glycerol, 0.06 part of L-menthol, 0.3 part of glacial acetic acid, 0.01 part of chymotrypsin, 0.05 part of sodium bicarbonate powder and 90 parts of purified water;

s2, preparing a first mixture: putting lidocaine hydrochloride in parts by weight into 20 parts of purified water, stirring to completely dissolve the lidocaine hydrochloride, adding glycerol, chymotrypsin and sodium bicarbonate powder in parts by weight, and uniformly stirring to obtain a first mixture;

s3, preparing a second mixture: adding purified water into glacial acetic acid in parts by weight to prepare an acetic acid solution with the concentration of 1%, adding chitosan and L-menthol in parts by weight to dissolve in the acetic acid solution, then adding sodium carboxymethylcellulose in a prescription amount, and stirring to completely swell to obtain a second mixture;

s4, preparing lubricating cement paste by mixing raw materials: and (3) uniformly mixing the first mixture in the S2 and the second mixture in the S3, adjusting the pH value to 6.0 by using a sodium hydroxide solution, adding the residual purified water to a sufficient amount, and uniformly mixing to obtain the lubricating cement.

Example 2

Referring to fig. 1, the present invention provides a technical solution: the lubricating mucilage for enteroscope detection comprises the following components in parts by weight: 3 parts of carbomer, 0.8 part of propylene glycol, 0.6 part of sodium hydroxide, 6 parts of lidocaine hydrochloride, 0.8 part of sodium carboxymethylcellulose, 0.6 part of chitosan, 4 parts of simethicone, 14 parts of glycerol, 0.16 part of L-menthol, 0.9 part of glacial acetic acid, 0.03 part of chymotrypsin, 0.1 part of sodium bicarbonate powder and 80 parts of purified water.

In this embodiment, preferably, the preparation method of lidocaine hydrochloride includes:

s1, sequentially adding sodium methoxide, 2, 6-dimethylaniline and N, N-diethylaminoacetic acid methyl ester into a reaction vessel, heating to 98 ℃, carrying out reaction while distilling to remove methanol generated in the reaction until no methanol is evaporated, continuing to react for 40min, and cooling to room temperature;

s2, adding dichloroethane, washing with water, standing and layering to obtain an organic layer, namely a dichloroethane solution of lidocaine base;

s3, adding hydrochloric acid into a dichloroethane solution of lidocaine base, adjusting the pH to 5 by using hydrogen chloride, adding activated carbon, refluxing for 45min, filtering, concentrating the filtrate, cooling, crystallizing and drying to obtain the lidocaine hydrochloride.

In this embodiment, preferably, the preparation method of 2, 6-dimethylaniline includes the following steps:

s1, sequentially adding 2, 6-xylenol, ammonia water, Pd/C and 2, 6-dimethylcyclohexanone into a reaction vessel, reacting for 4 hours at 200 ℃, cooling to room temperature, filtering, and recovering Pd/C for reuse;

s2, distilling the filtrate under reduced pressure, recovering 2, 6-dimethylcyclohexanone for the next use, washing residues with water, standing and layering to obtain an oil layer, namely the 2, 6-dimethylaniline.

In this embodiment, preferably, the preparation method of the dimethylsilicone oil includes the following steps:

s1, crushing, cleaning and drying waste high-temperature silicon vulcanized rubber;

s2, adding 130 parts by weight of crushed high-temperature silicon vulcanized rubber, 4 parts by weight of tetramethylammonium chloride and 240 parts by weight of butanone into a first reaction kettle with a vent pipe at the bottom, heating to 110 ℃, stirring for reaction for 1 hour, opening the vent pipe valve at the bottom of the first reaction kettle, continuously introducing nitrogen for bubbling, vacuumizing the reaction kettle to maintain the vacuum degree at 0.8Mpa for 6 hours, and continuously pumping out volatile gas;

s3, condensing the extracted gas, introducing the condensed gas into a second reaction kettle, vacuumizing to 0Mpa at 90 ℃ for dehydration, adding tetramethylammonium hydroxide with a catalytic amount, heating to 115 ℃ for heat preservation for 2 hours, adding an end sealing agent, and heating to 130 ℃ for reaction for 3 hours;

s4, heating the temperature to 200 ℃, breaking the catalyst for 4 hours, heating the temperature to 240 ℃, opening a vent pipe valve at the bottom of the second reaction kettle, continuously introducing nitrogen into the second reaction kettle under the stirring condition for bubbling, vacuumizing the reaction kettle to maintain the vacuum degree at 0.2Mpa for 4 hours, and continuously pumping out the volatilized gas, wherein the liquid in the second reaction kettle is the dimethyl silicon oil.

In this embodiment, preferably, the high-temperature vulcanized silicone rubber in S1 is pulverized to 60 meshes, and the cleaning manner in S1 is as follows: washing with water and then butanone, wherein the drying temperature in the S1 is 70 ℃.

In this embodiment, preferably, the capping agent in S3 is hexamethyldisiloxane.

In this embodiment, preferably, the preparation method of glycerol includes the following steps:

s1, decomposing starch by double enzymes to generate glucose, and fermenting by using yeast to generate crude glycerol;

s2, decomposing the crude glycerin obtained in the step S1 at the temperature of 210 ℃ to volatilize a part of decomposed substances in a gas form, filtering by using a plate frame to remove a part of coked substances generated by carbonization, performing ion exchange by using an anion-cation exchange column to remove decomposed residual substances, and finally performing vacuum concentration to form a medicinal glycerin product.

In this embodiment, it is preferable that the method further includes a method for preparing the lubricating cement, and the method for preparing the lubricating cement includes the following steps:

s1, raw material preparation: taking the following raw materials in parts by weight: 6 parts of lidocaine hydrochloride, 0.8 part of sodium carboxymethylcellulose, 0.6 part of chitosan, 4 parts of simethicone, 14 parts of glycerol, 0.16 part of L-menthol, 0.9 part of glacial acetic acid, 0.03 part of chymotrypsin, 0.1 part of sodium bicarbonate powder and 80 parts of purified water;

s2, preparing a first mixture: putting lidocaine hydrochloride in parts by weight into 20 parts of purified water, stirring to completely dissolve the lidocaine hydrochloride, adding glycerol, chymotrypsin and sodium bicarbonate powder in parts by weight, and uniformly stirring to obtain a first mixture;

s3, preparing a second mixture: adding purified water into glacial acetic acid in parts by weight to prepare an acetic acid solution with the concentration of 3%, adding chitosan and L-menthol in parts by weight to dissolve in the acetic acid solution, then adding sodium carboxymethylcellulose in a prescription amount, and stirring to completely swell to obtain a second mixture;

s4, preparing lubricating cement paste by mixing raw materials: and (3) uniformly mixing the first mixture in the S2 and the second mixture in the S3, adjusting the pH value to 7.0 by using a sodium hydroxide solution, adding the residual purified water to a sufficient amount, and uniformly mixing to obtain the lubricating cement.

Example 3

Referring to fig. 1, the present invention provides a technical solution: the lubricating mucilage for enteroscope detection comprises the following components in parts by weight: 2 parts of carbomer, 0.6 part of propylene glycol, 0.4 part of sodium hydroxide, 4 parts of lidocaine hydrochloride, 0.6 part of sodium carboxymethylcellulose, 0.4 part of chitosan, 3 parts of simethicone, 10 parts of glycerol, 0.12 part of L-menthol, 0.6 part of glacial acetic acid, 0.02 part of chymotrypsin, 0.08 part of sodium bicarbonate powder and 85 parts of purified water.

In this embodiment, preferably, the preparation method of lidocaine hydrochloride includes:

s1, sequentially adding sodium methoxide, 2, 6-dimethylaniline and N, N-diethylaminoacetic acid methyl ester into a reaction vessel, heating to 94 ℃, carrying out reaction while distilling to remove methanol generated in the reaction until no methanol is evaporated, continuing the reaction for 35min, and cooling to room temperature;

s2, adding dichloroethane, washing with water, standing and layering to obtain an organic layer, namely a dichloroethane solution of lidocaine base;

s3, adding hydrochloric acid into a dichloroethane solution of lidocaine base, adjusting the pH to 4 by using hydrogen chloride, adding activated carbon, refluxing for 35min, filtering, concentrating the filtrate, cooling, crystallizing and drying to obtain lidocaine hydrochloride.

In this embodiment, preferably, the preparation method of 2, 6-dimethylaniline includes the following steps:

s1, sequentially adding 2, 6-xylenol, ammonia water, Pd/C and 2, 6-dimethylcyclohexanone into a reaction vessel, reacting for 6 hours at 190 ℃, cooling to room temperature, filtering, and recovering Pd/C for reuse;

s2, distilling the filtrate under reduced pressure, recovering 2, 6-dimethylcyclohexanone for the next use, washing residues with water, standing and layering to obtain an oil layer, namely the 2, 6-dimethylaniline.

In this embodiment, preferably, the preparation method of the dimethylsilicone oil includes the following steps:

s1, crushing, cleaning and drying waste high-temperature silicon vulcanized rubber;

s2, adding 100 parts by weight of crushed high-temperature silicon vulcanized rubber, 2 parts by weight of tetramethylammonium chloride and 190 parts by weight of butanone into a first reaction kettle with a vent pipe at the bottom, heating to 100 ℃, stirring for reaction for 0.8 hour, opening a vent pipe valve at the bottom of the first reaction kettle, continuously introducing nitrogen for bubbling, vacuumizing the reaction kettle to maintain the vacuum degree at 0.6MPa for 5 hours, and continuously extracting volatile gas;

s3, condensing the extracted gas, introducing the condensed gas into a second reaction kettle, vacuumizing to-0.5 Mpa at 70 ℃ for dehydration, adding tetramethylammonium hydroxide with a catalytic amount, heating to 112 ℃ for heat preservation for 1.5 hours, adding an end sealing agent, and heating to 125 ℃ for reaction for 2 hours;

s4, heating the temperature to 180 ℃, breaking the catalyst for 3 hours, heating the temperature to 220 ℃, opening a vent pipe valve at the bottom of the second reaction kettle, continuously introducing nitrogen into the second reaction kettle under the stirring condition for bubbling, vacuumizing the reaction kettle to maintain the vacuum degree at 0.1Mpa for 2 hours, and continuously pumping out the volatilized gas, wherein the liquid in the second reaction kettle is the dimethyl silicon oil.

In this embodiment, it is preferable that the high-temperature vulcanized silicone rubber in S1 is pulverized into 40 mesh, and the cleaning method in S1 is: washing with water and then butanone, wherein the drying temperature in S1 is 60 ℃.

In this embodiment, preferably, the capping agent in S3 is hexamethyldisiloxane.

In this embodiment, preferably, the preparation method of glycerol includes the following steps:

s1, decomposing starch by double enzymes to generate glucose, and fermenting by using yeast to generate crude glycerol;

s2, decomposing the crude glycerin obtained in the step S1 at the temperature of 200 ℃ to volatilize a part of decomposed substances in a gas form, filtering the decomposed substances by using a plate frame to remove a part of coked substances generated by carbonization, performing ion exchange by using an anion-cation exchange column to remove decomposed residual substances, and finally performing vacuum concentration to form a medicinal glycerin product.

In this embodiment, it is preferable that the method further includes a method for preparing the lubricating cement, and the method for preparing the lubricating cement includes the following steps:

s1, raw material preparation: taking the following raw materials in parts by weight: 4 parts of lidocaine hydrochloride, 0.6 part of sodium carboxymethylcellulose, 0.4 part of chitosan, 3 parts of simethicone, 10 parts of glycerol, 0.12 part of L-menthol, 0.6 part of glacial acetic acid, 0.02 part of chymotrypsin, 0.08 part of sodium bicarbonate powder and 85 parts of purified water;

s2, preparing a first mixture: putting lidocaine hydrochloride in 35 parts by weight of purified water, stirring to completely dissolve the lidocaine hydrochloride, adding glycerol, chymotrypsin and sodium bicarbonate powder in parts by weight, and uniformly stirring to obtain a first mixture;

s3, preparing a second mixture: adding purified water into glacial acetic acid in parts by weight to prepare an acetic acid solution with the concentration of 2%, adding chitosan and L-menthol in parts by weight to dissolve in the acetic acid solution, then adding sodium carboxymethylcellulose in a prescription amount, and stirring to completely swell to obtain a second mixture;

s4, preparing lubricating cement paste by mixing raw materials: and (3) uniformly mixing the first mixture in the S2 and the second mixture in the S3, adjusting the pH value to 6.5 by using a sodium hydroxide solution, adding the residual purified water to a sufficient amount, and uniformly mixing to obtain the lubricating cement.

The working principle and the advantages of the invention are as follows: the lubricating mucilage is prepared from lidocaine hydrochloride, sodium carboxymethylcellulose, chitosan, simethicone, glycerol, L-menthol, glacial acetic acid, chymotrypsin, sodium bicarbonate powder and purified water, an oily film can be formed in the oral cavity of an esophagus by adding the glycerol, friction is reduced, a lubricating effect is further achieved, bubble tension can be reduced by adding the simethicone, bubble breakage is caused, an effect of eliminating bubbles is achieved, the visual field is relatively clear, local anesthesia can be caused to the oral cavity and the esophagus after the lubricating mucilage is taken by adding the lidocaine hydrochloride local anesthetic, irritation is reduced, and inspection and operation reactions are reduced.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims (9)

1. The utility model provides a lubricating cement for enteroscopy, its characterized in that: the coating comprises the following components in parts by weight: 1-3 parts of carbomer, 0.5-0.8 part of propylene glycol, 0.2-0.6 part of sodium hydroxide, 2-6 parts of lidocaine hydrochloride, 0.4-0.8 part of sodium carboxymethylcellulose, 0.2-0.6 part of chitosan, 1-4 parts of simethicone, 6-14 parts of glycerol, 0.06-0.16 part of L-menthol, 0.3-0.9 part of glacial acetic acid, 0.01-0.03 part of chymotrypsin, 0.05-0.1 part of sodium bicarbonate powder and 80-90 parts of purified water.

2. The lubricating cement for enteroscopy according to claim 1, wherein: the coating comprises the following components in parts by weight: 2 parts of carbomer, 0.6 part of propylene glycol, 0.3 part of sodium hydroxide, 4 parts of lidocaine hydrochloride, 0.6 part of sodium carboxymethylcellulose, 0.4 part of chitosan, 3 parts of simethicone, 10 parts of glycerol, 0.12 part of L-menthol, 0.6 part of glacial acetic acid, 0.02 part of chymotrypsin, 0.08 part of sodium bicarbonate powder and 85 parts of purified water.

3. The lubricating cement for enteroscopy according to claim 1, wherein: the preparation method of the lidocaine hydrochloride comprises the following steps:

s1, sequentially adding sodium methoxide, 2, 6-dimethylaniline and N, N-diethylaminoacetic acid methyl ester into a reaction vessel, heating to 88-98 ℃, distilling while reacting to remove methanol generated in the reaction until no methanol is evaporated, continuing to react for 30-40min, and cooling to room temperature;

s2, adding dichloroethane, washing with water, standing and layering to obtain an organic layer, namely a dichloroethane solution of lidocaine base;

s3, adding hydrochloric acid into a dichloroethane solution of lidocaine base, adjusting the pH to 3-5 with hydrogen chloride, adding activated carbon, refluxing for 20-45min, filtering, concentrating the filtrate, cooling, crystallizing, and drying to obtain lidocaine hydrochloride.

4. The lubricating cement for enteroscopy according to claim 3, wherein: the preparation method of the 2, 6-dimethylaniline comprises the following steps:

s1, sequentially adding 2, 6-xylenol, ammonia water, Pd/C and 2, 6-dimethylcyclohexanone into a reaction vessel, reacting for 4-9h at the temperature of 170-200 ℃, cooling to room temperature, filtering, and recovering Pd/C for reuse;

s2, distilling the filtrate under reduced pressure, recovering 2, 6-dimethylcyclohexanone for the next use, washing residues with water, standing and layering to obtain an oil layer, namely the 2, 6-dimethylaniline.

5. The lubricating cement for enteroscopy according to claim 1, wherein: the preparation method of the dimethyl silicone oil comprises the following steps:

s1, crushing, cleaning and drying waste high-temperature silicon vulcanized rubber;

s2, adding 70-130 parts by weight of crushed high-temperature silicon vulcanized rubber, 1-4 parts by weight of tetramethylammonium chloride and 240 parts by weight of butanone into a first reaction kettle with a vent pipe at the bottom, heating to 90-110 ℃, stirring for reaction for 0.5-1 hour, opening the vent pipe valve at the bottom of the first reaction kettle, continuously introducing nitrogen for bubbling, vacuumizing the reaction kettle to maintain the vacuum degree at 0.2-0.8 MPa for 4-6 hours, and continuously extracting volatile gas;

s3, condensing the extracted gas, introducing the condensed gas into a second reaction kettle, vacuumizing to-0.08 MPa-0MPa for dehydration at 60-90 ℃, adding tetramethylammonium hydroxide with a catalyst amount, heating to 110-phase and 115 ℃, preserving the temperature for 0.5-2 hours, adding a sealing agent, and heating to 120-phase and 130 ℃ for reaction for 1-3 hours;

s4, heating to 150-200 ℃, breaking the catalyst for 3-4 hours, heating to 200-240 ℃, opening a vent pipe valve at the bottom of the second reaction kettle, continuously introducing nitrogen into the second reaction kettle under the stirring condition for bubbling, vacuumizing the reaction kettle to maintain the vacuum degree at 0.04-0.2MPa for 1-4 hours, and continuously extracting volatilized gas, wherein the liquid in the second reaction kettle is the dimethyl silicon oil.

6. The lubricating cement for enteroscopy according to claim 5, wherein: the high-temperature silicon vulcanized rubber in the S1 is crushed into 10-60 meshes, and the cleaning mode in the S1 is as follows: washing with water and then butanone, wherein the drying temperature in the S1 is 40-70 ℃.

7. The lubricating cement for enteroscopy according to claim 5, wherein: the end sealing agent in the S3 is hexamethyldisiloxane.

8. The lubricating cement for enteroscopy according to claim 1, wherein: the preparation method of the glycerol comprises the following steps:

s1, decomposing starch by double enzymes to generate glucose, and fermenting by using yeast to generate crude glycerol;

s2, decomposing the crude glycerin obtained in the step S1 at the temperature of 190-210 ℃ to volatilize a part of decomposed substances in a gas form, filtering by using a plate frame to remove a part of coked substances generated by carbonization, performing ion exchange by using an anion-cation exchange column to remove residual substances after decomposition, and finally performing vacuum concentration to form a pharmaceutical grade glycerin product.

9. The lubricating cement for enteroscopy according to claim 1, wherein: the preparation method of the lubricating mucilage comprises the following steps:

s1, raw material preparation: taking the following raw materials in parts by weight: 2-6 parts of lidocaine hydrochloride, 0.4-0.8 part of sodium carboxymethylcellulose, 0.2-0.6 part of chitosan, 1-4 parts of simethicone, 6-14 parts of glycerol, 0.06-0.16 part of L-menthol, 0.3-0.9 part of glacial acetic acid, 0.01-0.03 part of chymotrypsin, 0.05-0.1 part of sodium bicarbonate powder and 80-90 parts of purified water;

s2, preparing a first mixture: putting lidocaine hydrochloride in parts by weight into 20-45 parts of purified water, stirring to completely dissolve, then adding glycerol, chymotrypsin and sodium bicarbonate powder in parts by weight, and stirring uniformly to obtain a first mixture;

s3, preparing a second mixture: adding purified water into glacial acetic acid in parts by weight to prepare an acetic acid solution with the concentration of 1-3%, adding chitosan and L-menthol in parts by weight to dissolve in the acetic acid solution, then adding sodium carboxymethylcellulose in a prescribed amount, and stirring to completely swell to obtain a second mixture;

s4, preparing lubricating cement paste by mixing raw materials: and (3) uniformly mixing the first mixture in the S2 and the second mixture in the S3, adjusting the pH value to 6.0-7.0 by adopting a sodium hydroxide solution, adding the residual purified water to a sufficient amount, and uniformly mixing to obtain the lubricating mucilage.

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