CN112546285A - 一种基于化学改性与物理针刺技术的藻酸盐敷料的制备方法 - Google Patents
一种基于化学改性与物理针刺技术的藻酸盐敷料的制备方法 Download PDFInfo
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Abstract
本发明公开了一种基于化学改性与物理针刺技术的藻酸盐敷料的制备方法,该制备方法包括:以纯藻酸盐短纤维作为原料,将藻酸盐纤维加入壳聚糖溶液中,再将新纤维加入氢氧化钙溶液中进行凝固,经洗涤和干燥获得含壳聚糖涂层的藻酸盐纤维;含壳聚糖涂层的藻酸盐纤维经开松、梳理、铺网以及特殊针刺技术制得壳聚糖改性的藻酸盐敷料。本发明的藻酸盐敷料可以应用于创面护理,其具有抗菌、吸收渗液、隔离渗液以及促进创面愈合的特性,有望成为新型医用敷料。
Description
技术领域
本发明涉及纺织材料和医疗器械技术领域,具体为一种基于化学改性与物理针刺技术的藻酸盐敷料的制备方法。
背景技术
藻酸盐纤维是一种以海藻酸钠为原料,经湿法纺丝技术制备得到的纤维,因其具有良好的生物相容性而被广泛用于医疗领域。藻酸盐纤维经非织造布技术制成藻酸盐无纺布,藻酸盐无纺布被分切或复合其他材料制成藻酸盐医用敷料,在与创面渗液接触时,海藻酸的钙盐能通过离子间交换,使不溶解性海藻酸盐钙变为可溶性藻酸钠,并释放出钙,具有极强的吸收性。这保证了伤口湿性愈合环境,延长换药时间,同时使伤口内的坏死组织自溶。但现有的藻酸盐敷料本身不具有抗菌性,一般会在藻酸盐纤维中加入银离子或纳米银增强其抗菌性,但银离子或纳米银存在代谢不确定性以及生物相容性较差等缺点而受到限制;在用于渗液较多的创面时,现有藻酸盐纤维敷料吸收大量渗液之后因隔离渗液性能较差而导致渗液浸渍周围正常皮肤,感染正常皮肤。
发明内容
本发明的目的在于提供一种基于化学改性与物理针刺技术的藻酸盐敷料的制备方法,在现有藻酸盐医用敷料的基础上,将化学改性与物理针刺技术相结合,改进现有藻酸盐医用敷料抗菌性和隔离渗液性能差的缺点,更好的发挥藻酸盐医用敷料在促进伤口愈合方面的作用。
本发明的技术方案如下:一种基于化学改性与物理针刺技术的藻酸盐敷料的制备方法,其制备方法包括以下步骤:
S1. 将藻酸盐纤维加入壳聚糖溶液中,浸泡10s~20s,其中所述壳聚糖溶液的质量分数为2%,溶剂为乙酸/乙醇混合溶液;
S2. 将步骤S1浸泡后的藻酸盐纤维,加入到氢氧化钙溶液中,浸泡10s~15s后取出,用纯化水洗涤3次,再用烘箱进行烘干;
S3. 烘干后的壳聚糖改性的藻酸盐纤维经开松、梳理、铺网以及特殊针刺技术工序,即制得所述藻酸盐敷料。
优选的,步骤S1所述藻酸盐纤维的长度为5cm~8cm,其钙离子含量为4%~10%。
优选的,步骤S1中所述乙酸/乙醇混合溶液中乙酸与乙醇的体积比为1:40~1:20。
优选的,步骤S2中所述氢氧化钙的浓度为0.05mol/l~0.2mol/l。
优选的,步骤S3中所述特殊针刺技术所用的钢针的表面含有10根倒刺。
优选的,步骤 S3中所述特殊针刺技术所用的针板上钢针的排布成S型且密度为2刺/cm2。
优选的,步骤S3中所述特殊针刺技术是以速度200次/min和15mm~35mm的深度下针刺。
与现有技术相比,本发明的有益效果为:
(1)本发明由壳聚糖改性的藻酸盐纤维纺织成藻酸盐敷料具有优良的生物相容性能、抗菌性能以及止血性能;
(2)本发明经特殊针刺技术制成的藻酸盐敷料具有优异的隔离渗液能力以及吸液性。
附图说明
图1为本发明S型排布的针板的结构示意图;
图2为本发明含有10根倒刺的钢针的结构示意图。
具体实施方式
实施例一:
一种基于化学改性与物理针刺技术的藻酸盐敷料的制备方法,包括以下步骤:
(1)将长度为7cm的纯藻酸盐短纤维(钙离子含量为6%)加入壳聚糖溶液中,浸泡10s,其中壳聚糖溶液的质量分数为2%,溶剂为乙酸/乙醇混合溶液(v/v=1:30);
(2)浸泡后的纤维,取出后加入0.1mol/l的氢氧化钙溶液中,浸泡10s后取出,用纯化水洗涤3次,再用烘箱进行烘干;
(3)烘干后的壳聚糖改性的藻酸盐纤维经开松、梳理、铺网以及特殊针刺技术工序,其中针刺技术采用S型排布的针板,如图1所示,以及含10根倒刺结构的钢针,如图2所示,以速度200次/min和30mm的深度下针刺得到壳聚糖改性藻酸盐敷料。
对比例二
一种基于化学改性与物理针刺技术的藻酸盐敷料的制备方法,包括以下步骤:
(1)将长度为7cm的纯藻酸盐短纤维(钙离子含量为6%)加入壳聚糖溶液中,浸泡10s,其中壳聚糖溶液的质量分数为2%,溶剂为乙酸/乙醇混合溶液(v/v=1:30);
(2)浸泡后的纤维,取出后加入0.1mol/l的氢氧化钙溶液中,浸泡10s后取出,用纯化水洗涤3次,再用烘箱进行烘干;
(3)烘干后的壳聚糖改性的藻酸盐纤维经开松、梳理、铺网以及针刺技术工序,其中针刺技术采用普通型排布的针布以及普通结构的钢针,以速度200次/min和30mm的深度下针刺得到壳聚糖改性藻酸盐敷料。
对比例三
一种基于化学改性与物理针刺技术的藻酸盐敷料的制备方法,包括以下步骤:
(1)将长度为7cm的纯藻酸盐短纤维(钙离子含量为6%)加入壳聚糖溶液中,浸泡10s,其中壳聚糖溶液的质量分数为1%,溶剂为乙酸/乙醇混合溶液(v/v=1:30);
(2)浸泡后的纤维,取出后加入0.1mol/l的氢氧化钙溶液中,浸泡10s后取出,用纯化水洗涤3次,再用烘箱进行烘干;
(3)烘干后的壳聚糖改性的藻酸盐纤维经开松、梳理、铺网以及针刺技术工序,其中针刺技术采用普通型排布的针板以及普通结构的钢针,以速度200次/min和30mm的深度下针刺得到壳聚糖改性藻酸盐敷料。
实施例四 检测试验
吸液性:按照YY/T 0471.1-2004中3.2进行试验;
隔离渗液性:取壳聚糖改性藻酸盐敷料剪成100mm×10mm长条形,在一个500ml的烧杯中加入300ml试验液A(按照YY/T 0471.1-2004的3.2.2.3项进行配制),用镊子夹住100mm×10mm试样的一端把它垂直浸入试验液A中10mm左右,记录5min后液体所爬升的高度。
抗菌性:将壳聚糖改性藻酸盐敷料剪成2.0cm×2.0cm大小,置于无菌锥形瓶中作为样片组,并按上述方法将对照例三得到的基质敷料作为对照样片组。将2组分别加入70mL磷酸盐缓冲液(0.03mol·L-1)和5mL金黄色葡萄球菌(或白色念球菌或大肠杆菌)的菌液,待液体渗入培养基中后,37℃培养12-24小时,进行菌落计数。
止血性:将壳聚糖改性藻酸盐敷料剪成2.0cm×2.0cm大小,加入装有5mlSD大鼠血液的玻璃管中,开始计时,直至血液完全凝固为止,则停止计时,计时凝血时间。
经检测,本发明实施例1与对比例2和3制备的藻酸盐敷料的吸液性、隔离渗液性、抗菌性和止血性的实验结果如下所示:
由上表可知,本发明制备的基于化学改性与物理针刺技术的藻酸盐敷料,具有优异的抗菌、吸收渗液、隔离渗液以及止血的特性。
以上对本发明的特定实施例进行了说明,但本发明的保护内容不仅仅限定于以上实施例,在本发明的所属技术领域中,只要掌握通常知识,就可以在其技术要旨范围内进行多种多样的变更。
Claims (7)
1.一种基于化学改性与物理针刺技术的藻酸盐敷料的制备方法,其特征在于:所述制备方法包括以下步骤:
S1. 将藻酸盐纤维加入壳聚糖溶液中,浸泡10s~20s,其中所述壳聚糖溶液的质量分数为2%,溶剂为乙酸/乙醇混合溶液;
S2. 将步骤S1浸泡后的藻酸盐纤维,加入到氢氧化钙溶液中,浸泡10s~15s后取出,用纯化水洗涤3次,再用烘箱进行烘干;
S3. 烘干后的壳聚糖改性的藻酸盐纤维经开松、梳理、铺网以及特殊针刺技术,即制得所述藻酸盐敷料。
2.根据权利要求1所述一种基于化学改性与物理针刺技术的藻酸盐敷料的制备方法,其特征在于,步骤S1中所述藻酸盐纤维的长度为5cm~8cm,其钙离子含量为4%~10%。
3.根据权利要求1所述一种基于化学改性与物理针刺技术的藻酸盐敷料的制备方法,其特征在于,步骤S1中所述乙酸/乙醇混合溶液中乙酸与乙醇的体积比为1:40~1:20。
4.根据权利要求1所述一种基于化学改性与物理针刺技术的藻酸盐敷料的制备方法,其特征在于,步骤S2中所述氢氧化钙的浓度为0.05mol/l~0.2mol/l。
5.根据权利要求1所述一种基于化学改性与物理针刺技术的藻酸盐敷料的制备方法,其特征在于,步骤S3中所述特殊针刺技术所用的钢针的表面含有10根倒刺。
6.根据权利要求1所述一种基于化学改性与物理针刺技术的藻酸盐敷料的制备方法,其特征在于,步骤 S3中所述特殊针刺技术所用的针板上钢针的排布成S型且密度为2刺/cm2。
7.根据权利要求1所述一种基于化学改性与物理针刺技术的藻酸盐敷料的制备方法,其特征在于,步骤S3中所述特殊针刺技术是以速度200次/min和15mm~35mm的深度下针刺。
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