CN112546207A - Medicine for treating urinary calculus and preparation method thereof - Google Patents
Medicine for treating urinary calculus and preparation method thereof Download PDFInfo
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- CN112546207A CN112546207A CN202110118103.8A CN202110118103A CN112546207A CN 112546207 A CN112546207 A CN 112546207A CN 202110118103 A CN202110118103 A CN 202110118103A CN 112546207 A CN112546207 A CN 112546207A
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- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4873—Cysteine endopeptidases (3.4.22), e.g. stem bromelain, papain, ficin, cathepsin H
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Abstract
The invention relates to the technical field of medical auxiliary medicines, in particular to a medicine for treating urinary calculus and a preparation method thereof, wherein the medicine comprises the following raw materials in parts by weight: 15-25 parts of radish seed, 15-23 parts of cluster mallow seed, 5-15 parts of loranthus parasiticus, 10-15 parts of curcuma zedoary, 15-25 parts of lysimachia christinae hance, 10-20 parts of spina gleditsiae, 10-20 parts of pseudo-ginseng powder, 5-10 parts of prepared myrrh, 10-15 parts of raw fleece-flower root, 10-20 parts of gentian scabra bunge, 5-10 parts of cornu cervi degelatinatum, 10-15 parts of raw acorus calamus, 10-20 parts of licorice root tip, 5-15 parts of fructus aurantii, 3-9 parts of pericarpium citri reticulatae viride, 5-13 parts of plantain herb, 10-20 parts of potassium citrate, 10-16 parts of tiopronin, 10-15 parts of allopurinol and 15-20. The invention not only can improve the bacteriostatic effect in the urinary system, but also can improve the inhibitory action on the formation of calculus.
Description
Technical Field
The invention relates to the technical field of medical auxiliary medicines, in particular to a medicine for treating urinary calculus and a preparation method thereof.
Background
Urinary calculus is a common disease of urinary system, and can be found in any part of kidney, bladder, ureter and urethra, but kidney and ureter calculus are common, and clinical manifestations are different depending on the position of calculus. Renal and ureteral calculi are typically manifested as renal colic and hematuria, before the onset of colic caused by calculi, patients do not feel any sense, and suddenly have severe colic at one side of waist due to some inducements, such as severe exercise, labor, long-distance riding and the like, and radiate to the lower abdomen and perineum with abdominal distension, nausea, vomiting and hematuria of different degrees; bladder stones are mainly characterized by difficulty in urination and pain in urination.
In urinary calculus diseases, the treatment is also affected by the infection of pathogenic bacteria, wherein the most common pathogenic bacteria are escherichia coli and staphylococcus aureus, and part of calculus is formed by the gradual enlargement of blood platelets and the like due to the continuous aggregation, so that a medicine for treating urinary calculus and a preparation method thereof are provided for solving the problems.
Disclosure of Invention
The invention aims to solve the defects in the prior art and provides a medicine for treating urinary calculus and a preparation method thereof.
The medicine for treating urinary calculus comprises the following raw materials in parts by weight: 15-25 parts of radish seed, 15-23 parts of cluster mallow seed, 5-15 parts of loranthus parasiticus, 10-15 parts of curcuma zedoary, 15-25 parts of lysimachia christinae hance, 10-20 parts of spina gleditsiae, 10-20 parts of pseudo-ginseng powder, 5-10 parts of prepared myrrh, 10-15 parts of raw fleece-flower root, 10-20 parts of gentian scabra bunge, 5-10 parts of cornu cervi degelatinatum, 10-15 parts of raw acorus calamus, 10-20 parts of licorice root tip, 5-15 parts of fructus aurantii, 3-9 parts of pericarpium citri reticulatae viride, 5-13 parts of plantain herb, 10-20 parts of potassium citrate, 10-16 parts of tiopronin, 10-15 parts of allopurinol and 15-20;
the antibacterial pineapple juice beverage further comprises 13-20 parts of antibacterial extracting solution and 15-20 parts of pineapple fruit leaching solution.
Preferably, the antibacterial extracting solution is prepared from houttuynia cordata, sorbic acid, rheum officinale, Chinese holly and groundsel.
Preferably, the preparation method of the antibacterial extracting solution comprises the following steps: drying and crushing houttuynia cordata, sorbic acid, rheum officinale, Chinese holly and groundsel, extracting the dried and crushed houttuynia cordata, sorbic acid, rheum officinale, Chinese holly and groundsel for 4 days at normal temperature respectively to obtain five extracting solutions, mixing and centrifuging the four extracting solutions, distilling the four extracting solutions at 50 ℃ under reduced pressure, evaporating alcohol in the extracting solutions, and then fixing the volume to 1g/mL by using distilled water to obtain the antibacterial extracting solution.
Preferably, the pineapple fruit extract is prepared from bromelain, glucose, ginger, garlic and onion.
Preferably, the preparation method of the pineapple fruit leaching liquor comprises the following steps:
the method comprises the following steps: cleaning ginger, garlic and onion, cutting into sections, adding water, cooking for 15-25 minutes, and collecting cooled juice;
step two: mixing bromelain and glucose, pouring the collected juice, and stirring to obtain pineapple fruit extract.
The preparation method of the medicine for treating urinary calculus comprises the following steps:
s1, weighing the medicinal materials according to the amount, adding an appropriate amount of water for decocting and extracting for the first time, decocting for 1.5-2.5 hours, filtering out the liquid medicine for later use, adding an appropriate amount of water for continuous decocting for 1-1.2 hours for the second time, filtering out the liquid medicine for later use, adding an appropriate amount of water for continuous decocting for 0.8-1.2 hours for the third time, and filtering out the liquid medicine for later use;
s2, combining the liquid medicines decocted for three times in the step S1, filtering, collecting filtrate, concentrating the filtrate, and centrifuging at the rotating speed of 2700-3300 r/min to obtain centrifugate;
s3, adding appropriate amount of sucrose and essence into the centrifugate, mixing, sterilizing, and bottling to obtain medicinal liquid.
Preferably, in the S1, the amount of water added for the first time is 8-10 times of the total weight of the medicinal materials, and the amount of water added for the second time and the third time is 6-8 times of the total weight of the medicinal materials.
Preferably, the filtrate in S2 has a relative density of 1 at 60 ℃ after concentration.
Compared with the prior art, the invention has the beneficial effects that:
1. according to the invention, houttuynia cordata, sorbic acid, rheum officinale, Chinese holly and groundsel are extracted, centrifuged, distilled and subjected to constant volume to prepare the antibacterial extracting solution, so that the bacteria in the urinary system can be inhibited, and the anti-inflammatory effect is achieved.
2. The addition of glucose into bromelain helps to promote the activity of bromelain and keep the bromelain stable, and the ginger, garlic and onion added in addition can play a role in inhibiting platelet aggregation and thromboxane formation, so that the inhibition effect on calculus formation is improved.
As described above, the present invention can improve not only the anti-inflammatory effect in the urinary system but also the inhibitory effect on the formation of calculi.
Detailed Description
The present invention will be further illustrated with reference to the following specific examples.
The medicine for treating urinary calculus comprises the following raw materials in parts by weight: 15-25 parts of radish seed, 15-23 parts of cluster mallow seed, 5-15 parts of loranthus parasiticus, 10-15 parts of curcuma zedoary, 15-25 parts of lysimachia christinae hance, 10-20 parts of spina gleditsiae, 10-20 parts of pseudo-ginseng powder, 5-10 parts of prepared myrrh, 10-15 parts of raw fleece-flower root, 10-20 parts of gentian scabra bunge, 5-10 parts of cornu cervi degelatinatum, 10-15 parts of raw acorus calamus, 10-20 parts of licorice root tip, 5-15 parts of fructus aurantii, 3-9 parts of pericarpium citri reticulatae viride, 5-13 parts of plantain herb, 10-20 parts of potassium citrate, 10-16 parts of tiopronin, 10-15 parts of allopurinol, 15-20 parts of tamsulosin, 13-20 parts of bacteriostatic extracting solution and.
The antibacterial extracting solution is prepared from houttuynia cordata, sorbic acid, rhubarb, Chinese holly and groundsel, and the preparation method comprises the following steps: drying and crushing houttuynia cordata, sorbic acid, rheum officinale, Chinese holly and groundsel, extracting the dried and crushed houttuynia cordata, sorbic acid, rheum officinale, Chinese holly and groundsel for 4 days at normal temperature respectively to obtain five extracting solutions, mixing and centrifuging the four extracting solutions, distilling the four extracting solutions at 50 ℃ under reduced pressure, evaporating alcohol in the extracting solutions, and then fixing the volume to 1g/mL by using distilled water to obtain the antibacterial extracting solution.
The pineapple fruit leaching liquor is prepared from bromelain, glucose, ginger, garlic and onion, and the preparation method comprises the following steps:
the method comprises the following steps: cleaning rhizoma Zingiberis recens, Bulbus Allii and Bulbus Allii Cepae, cutting into segments, adding water, decocting for 15 min, and collecting cooled juice;
step two: mixing bromelain and glucose, pouring the collected juice, and stirring to obtain pineapple fruit extract.
The preparation method of the medicine for treating urinary calculus comprises the following steps:
s1, weighing the medicinal materials according to the amount, decocting and extracting the medicinal materials for 1.5 hours by adding 8 times of water in the total weight of the medicinal materials for the first time, filtering out the liquid medicine for later use, adding 6 times of water for continuous decoction for 1 hour for the second time, filtering out the liquid medicine for later use, adding 6 times of water for decoction for 0.8 hour for the third time, and filtering out the liquid medicine for later use;
s2, combining the liquid medicines decocted in S1 for three times, filtering, collecting filtrate, concentrating the filtrate until the relative density of the filtrate is 1 at 60 ℃, and centrifuging at the rotating speed of 3000r/min to obtain centrifugate;
s3, adding appropriate amount of sucrose and essence into the centrifugate, mixing, sterilizing, and bottling to obtain medicinal liquid.
The first embodiment is as follows:
the medicine for treating urinary calculus comprises the following raw materials in parts by weight: 15 parts of radish seed, 15 parts of cluster mallow seed, 5 parts of Chinese taxillus twig, 10 parts of curcuma zedoary, 15 parts of lysimachia christinae hance, 10 parts of Chinese honeylocust spine, 10 parts of pseudo-ginseng powder, 5 parts of prepared myrrh, 10 parts of raw fleece-flower root, 10 parts of gentian, 5 parts of deglued antler powder, 10 parts of raw calamus, 10 parts of licorice root tip, 5 parts of bitter orange, 3 parts of green tangerine peel, 5 parts of plantain herb, 10 parts of potassium citrate, 10 parts of tiopronin, 10 parts of allopurinol, 15 parts of tamsulosin, 13 parts of bacteriostatic extracting solution and 15 parts of pineapple fruit extracting solution.
Example two:
the medicine for treating urinary calculus comprises the following raw materials in parts by weight: 20 parts of radish seed, 18 parts of cluster mallow seed, 10 parts of Chinese taxillus twig, 12 parts of curcuma zedoary, 20 parts of lysimachia christinae hance, 15 parts of Chinese honeylocust spine, 15 parts of pseudo-ginseng powder, 8 parts of prepared myrrh, 12 parts of raw fleece-flower root, 15 parts of gentian, 8 parts of deglued antler powder, 12 parts of raw calamus, 15 parts of licorice root tip, 10 parts of bitter orange, 6 parts of green tangerine orange peel, 8 parts of plantain herb, 15 parts of potassium citrate, 13 parts of tiopronin, 12 parts of allopurinol, 17 parts of tamsulosin, 16 parts of bacteriostatic extracting solution and 18 parts of pineapple fruit extracting solution.
Example three:
the medicine for treating urinary calculus comprises the following raw materials in parts by weight: 25 parts of radish seed, 23 parts of cluster mallow seed, 15 parts of Chinese taxillus twig, 15 parts of curcuma zedoary, 25 parts of lysimachia christinae hance, 20 parts of Chinese honeylocust spine, 20 parts of pseudo-ginseng powder, 10 parts of prepared myrrh, 15 parts of raw fleece-flower root, 20 parts of gentian, 10 parts of deglued antler powder, 15 parts of raw calamus, 20 parts of licorice root tip, 15 parts of bitter orange, 9 parts of green tangerine orange peel, 13 parts of plantain herb, 20 parts of potassium citrate, 16 parts of tiopronin, 15 parts of allopurinol, 20 parts of tamsulosin, 20 parts of bacteriostatic extracting solution and 20 parts of pineapple fruit extracting solution.
In each of the first to third embodiments, the preparation of the drug for treating urinary calculus is performed by the following steps:
s1, weighing the medicinal materials according to the amount, decocting and extracting the medicinal materials for 1.5 hours by adding 8 times of water in the total weight of the medicinal materials for the first time, filtering out the liquid medicine for later use, adding 6 times of water for continuous decoction for 1 hour for the second time, filtering out the liquid medicine for later use, adding 6 times of water for decoction for 0.8 hour for the third time, and filtering out the liquid medicine for later use;
s2, combining the liquid medicines decocted in S1 for three times, filtering, collecting filtrate, concentrating the filtrate until the relative density of the filtrate is 1 at 60 ℃, and centrifuging at the rotating speed of 3000r/min to obtain centrifugate;
s3, adding appropriate amount of sucrose and essence into the centrifugate, mixing, sterilizing, and bottling to obtain medicinal liquid.
Test one: determination of bacteriostatic effect on medicine
Comparative example one:
the medicine for treating urinary calculus comprises the following raw materials in parts by weight: 15 parts of radish seed, 15 parts of cluster mallow seed, 5 parts of Chinese taxillus twig, 10 parts of curcuma zedoary, 15 parts of lysimachia christinae hance, 10 parts of Chinese honeylocust spine, 10 parts of pseudo-ginseng powder, 5 parts of prepared myrrh, 10 parts of raw fleece-flower root, 10 parts of gentian, 5 parts of deglued antler powder, 10 parts of raw calamus, 10 parts of licorice root tip, 5 parts of bitter orange, 3 parts of green tangerine peel, 5 parts of plantain herb, 10 parts of potassium citrate, 10 parts of tiopronin, 10 parts of allopurinol, 15 parts of tamsulosin and 15 parts of pineapple fruit extract.
Comparative example two:
the medicine for treating urinary calculus comprises the following raw materials in parts by weight: 20 parts of radish seed, 18 parts of cluster mallow seed, 10 parts of Chinese taxillus twig, 12 parts of curcuma zedoary, 20 parts of lysimachia christinae hance, 15 parts of Chinese honeylocust spine, 15 parts of pseudo-ginseng powder, 8 parts of prepared myrrh, 12 parts of raw fleece-flower root, 15 parts of gentian, 8 parts of deglued antler powder, 12 parts of raw calamus, 15 parts of licorice root tip, 10 parts of bitter orange, 6 parts of green tangerine orange peel, 8 parts of plantain herb, 15 parts of potassium citrate, 13 parts of tiopronin, 12 parts of allopurinol, 17 parts of tamsulosin and 18 parts of pineapple fruit leaching liquor.
Comparative example three:
the medicine for treating urinary calculus comprises the following raw materials in parts by weight: 25 parts of radish seed, 23 parts of cluster mallow seed, 15 parts of Chinese taxillus twig, 15 parts of zedoary, 25 parts of lysimachia christinae hance, 20 parts of Chinese honeylocust spine, 20 parts of pseudo-ginseng powder, 10 parts of prepared myrrh, 15 parts of raw fleece-flower root, 20 parts of gentian, 10 parts of deglued antler powder, 15 parts of raw calamus, 20 parts of licorice root tip, 15 parts of bitter orange, 9 parts of green tangerine orange peel, 13 parts of plantain herb, 20 parts of potassium citrate, 16 parts of tiopronin, 15 parts of allopurinol, 20 parts of tamsulosin and 20 parts of pineapple fruit leaching liquor.
In the first to third comparative examples, the medicine for treating urinary calculus is prepared by the following steps:
s1, weighing the medicinal materials according to the amount, decocting and extracting the medicinal materials for 1.5 hours by adding 8 times of water in the total weight of the medicinal materials for the first time, filtering out the liquid medicine for later use, adding 6 times of water for continuous decoction for 1 hour for the second time, filtering out the liquid medicine for later use, adding 6 times of water for decoction for 0.8 hour for the third time, and filtering out the liquid medicine for later use;
s2, combining the liquid medicines decocted in S1 for three times, filtering, collecting filtrate, concentrating the filtrate until the relative density of the filtrate is 1 at 60 ℃, and centrifuging at the rotating speed of 3000r/min to obtain centrifugate;
s3, adding appropriate amount of sucrose and essence into the centrifugate, mixing, sterilizing, and bottling to obtain medicinal liquid.
Taking the medicines prepared in the first to third examples and the first to third comparative examples, performing bacteriostasis tests on the medicines (taking escherichia coli and staphylococcus aureus as examples) by adopting a viable count method,
the SBF simulated body fluid mainly comprises sodium chloride, potassium chloride, dipotassium hydrogen phosphate, magnesium chloride, calcium chloride, Tris, sodium bicarbonate and the like, and is subjected to aseptic treatment with pH =7.4
Will be 3X 103Respectively adding the test bacteria (escherichia coli/staphylococcus aureus) into quantitative medicaments with the same concentration, sampling respectively after 5 hours and 10 hours of action, counting the number of live bacteria, calculating the lethality of the medicaments to the test bacteria from the number of surviving microorganisms, and recording in the following table:
as can be seen from the data in the above table, the bacteriostatic effect of the drugs in the examples is maintained for a longer time with the time, while the bacteriostatic effect of the drugs in the comparative examples tends to be in a steady state after the drug lasts for a shorter time, so it can be seen that the bacteriostatic effect of the drugs prepared by the above series of formulations is better than that of the drugs prepared by the comparative examples without the bacteriostatic extract.
And (2) test II: measurement of blood clot coagulation inhibition
Comparative example four:
the medicine for treating urinary calculus comprises the following raw materials in parts by weight: 15 parts of radish seed, 15 parts of cluster mallow seed, 5 parts of Chinese taxillus twig, 10 parts of curcuma zedoary, 15 parts of lysimachia christinae hance, 10 parts of Chinese honeylocust spine, 10 parts of pseudo-ginseng powder, 5 parts of prepared myrrh, 10 parts of raw fleece-flower root, 10 parts of gentian, 5 parts of deglued antler powder, 10 parts of raw calamus, 10 parts of licorice root tip, 5 parts of bitter orange, 3 parts of green tangerine peel, 5 parts of plantain herb, 10 parts of potassium citrate, 10 parts of tiopronin, 10 parts of allopurinol, 15 parts of tamsulosin and 13 parts of bacteriostatic extracting solution.
Comparative example five:
the medicine for treating urinary calculus comprises the following raw materials in parts by weight: 20 parts of radish seed, 18 parts of cluster mallow seed, 10 parts of Chinese taxillus twig, 12 parts of curcuma zedoary, 20 parts of lysimachia christinae hance, 15 parts of Chinese honeylocust spine, 15 parts of pseudo-ginseng powder, 8 parts of prepared myrrh, 12 parts of raw fleece-flower root, 15 parts of gentian, 8 parts of deglued antler powder, 12 parts of raw calamus, 15 parts of licorice root tip, 10 parts of bitter orange, 6 parts of green tangerine orange peel, 8 parts of plantain herb, 15 parts of potassium citrate, 13 parts of tiopronin, 12 parts of allopurinol, 17 parts of tamsulosin and 16 parts of bacteriostatic extracting solution.
Comparative example six:
the medicine for treating urinary calculus comprises the following raw materials in parts by weight: 25 parts of radish seed, 23 parts of cluster mallow seed, 15 parts of Chinese taxillus twig, 15 parts of zedoary, 25 parts of lysimachia christinae hance, 20 parts of Chinese honeylocust spine, 20 parts of pseudo-ginseng powder, 10 parts of prepared myrrh, 15 parts of raw fleece-flower root, 20 parts of gentian, 10 parts of deglued antler powder, 15 parts of raw calamus, 20 parts of licorice root tip, 15 parts of bitter orange, 9 parts of green tangerine orange peel, 13 parts of plantain herb, 20 parts of potassium citrate, 16 parts of tiopronin, 15 parts of allopurinol, 20 parts of tamsulosin and 20 parts of bacteriostatic extracting solution.
In the fourth to sixth comparative examples, the medicine for treating urinary calculus is prepared by the following steps:
s1, weighing the medicinal materials according to the amount, decocting and extracting the medicinal materials for 1.5 hours by adding 8 times of water in the total weight of the medicinal materials for the first time, filtering out the liquid medicine for later use, adding 6 times of water for continuous decoction for 1 hour for the second time, filtering out the liquid medicine for later use, adding 6 times of water for decoction for 0.8 hour for the third time, and filtering out the liquid medicine for later use;
s2, combining the liquid medicines decocted in S1 for three times, filtering, collecting filtrate, concentrating the filtrate until the relative density of the filtrate is 1 at 60 ℃, and centrifuging at the rotating speed of 3000r/min to obtain centrifugate;
s3, adding appropriate amount of sucrose and essence into the centrifugate, mixing, sterilizing, and bottling to obtain medicinal liquid.
Reference example one:
the medicine for treating urinary calculus comprises the following raw materials in parts by weight: 15 parts of radish seed, 15 parts of cluster mallow seed, 5 parts of Chinese taxillus twig, 10 parts of curcuma zedoary, 15 parts of lysimachia christinae hance, 10 parts of Chinese honeylocust spine, 10 parts of pseudo-ginseng powder, 5 parts of prepared myrrh, 10 parts of raw fleece-flower root, 10 parts of gentian, 5 parts of deglued antler powder, 10 parts of raw calamus, 10 parts of licorice root tip, 5 parts of bitter orange, 3 parts of green tangerine peel, 5 parts of plantain herb, 10 parts of potassium citrate, 10 parts of tiopronin, 10 parts of allopurinol, 15 parts of tamsulosin, 13 parts of bacteriostatic extracting solution and 15 parts of pineapple fruit extracting solution.
Reference example two:
the medicine for treating urinary calculus comprises the following raw materials in parts by weight: 20 parts of radish seed, 18 parts of cluster mallow seed, 10 parts of Chinese taxillus twig, 12 parts of curcuma zedoary, 20 parts of lysimachia christinae hance, 15 parts of Chinese honeylocust spine, 15 parts of pseudo-ginseng powder, 8 parts of prepared myrrh, 12 parts of raw fleece-flower root, 15 parts of gentian, 8 parts of deglued antler powder, 12 parts of raw calamus, 15 parts of licorice root tip, 10 parts of bitter orange, 6 parts of green tangerine orange peel, 8 parts of plantain herb, 15 parts of potassium citrate, 13 parts of tiopronin, 12 parts of allopurinol, 17 parts of tamsulosin, 16 parts of bacteriostatic extracting solution and 18 parts of pineapple fruit extracting solution.
Reference example three:
the medicine for treating urinary calculus comprises the following raw materials in parts by weight: 25 parts of radish seed, 23 parts of cluster mallow seed, 15 parts of Chinese taxillus twig, 15 parts of curcuma zedoary, 25 parts of lysimachia christinae hance, 20 parts of Chinese honeylocust spine, 20 parts of pseudo-ginseng powder, 10 parts of prepared myrrh, 15 parts of raw fleece-flower root, 20 parts of gentian, 10 parts of deglued antler powder, 15 parts of raw calamus, 20 parts of licorice root tip, 15 parts of bitter orange, 9 parts of green tangerine orange peel, 13 parts of plantain herb, 20 parts of potassium citrate, 16 parts of tiopronin, 15 parts of allopurinol, 20 parts of tamsulosin, 20 parts of bacteriostatic extracting solution and 20 parts of pineapple fruit extracting solution.
In the first to third reference examples, the pineapple fruit leaching solution is only an aqueous solution containing bromelain, and the medicine for treating urinary calculus is prepared through the following steps:
s1, weighing the medicinal materials according to the amount, decocting and extracting the medicinal materials for 1.5 hours by adding 8 times of water in the total weight of the medicinal materials for the first time, filtering out the liquid medicine for later use, adding 6 times of water for continuous decoction for 1 hour for the second time, filtering out the liquid medicine for later use, adding 6 times of water for decoction for 0.8 hour for the third time, and filtering out the liquid medicine for later use;
s2, combining the liquid medicines decocted in S1 for three times, filtering, collecting filtrate, concentrating the filtrate until the relative density of the filtrate is 1 at 60 ℃, and centrifuging at the rotating speed of 3000r/min to obtain centrifugate;
s3, adding appropriate amount of sucrose and essence into the centrifugate, mixing, sterilizing, and bottling to obtain medicinal liquid.
Taking the medicines in the first to third examples, the fourth to sixth comparative examples and the first to third reference examples, preparing an SBF simulated body fluid (the SBF simulated body fluid mainly comprises sodium chloride, potassium chloride, dipotassium hydrogen phosphate, magnesium chloride, calcium chloride, Tris, sodium bicarbonate and the like, is subjected to sterile treatment, has pH = 7.4), dividing the SBF simulated body fluid into nine parts, placing the nine parts in different beakers respectively, pouring the 9 medicines into the beakers respectively, dripping 50mL of plasma into the beakers respectively to reach a constant volume of 120mL, storing the beakers in a sterile test box, observing and recording the coagulation conditions of the plasma at 1 day, 2 days, 3 days, 5 days and 7 days:
from the above data, it can be seen that the coagulation of the plasma tends to be stable and no coagulation occurs in a short period of time after the drugs in the examples are added, the coagulation time of the plasma is earlier than that in the examples after the drugs in the reference examples are added, while the drugs in the comparative examples have the worst coagulation inhibition effect on the plasma and the coagulation occurs in a short period of time, so that the drugs prepared by the formulations in the examples have the best inhibition effect on blood clots, that is, the probability of formation of clots due to aggregation of platelets and the like is reduced, and the problem of formation of stones from the clots is not caused.
And (3) test III: determination of Bromelain Activity contained in drug
Two control groups of pineapple fruit extracts were designed as follows:
comparison group (i):
the method comprises the following steps: cleaning ginger, garlic and onion, cutting into sections, adding water, cooking for 15-25 minutes, and collecting cooled juice;
step two: mixing bromelain and glucose, pouring the collected juice, and stirring to obtain pineapple fruit extract.
Comparison group 2:
the method comprises the following steps: cleaning ginger, garlic and onion, cutting into sections, adding water, cooking for 15-25 minutes, and collecting cooled juice;
step two: mixing bromelain with the juice, and stirring to obtain pineapple fruit extract.
Then, by using an FIP method, casein is used as a substrate, the concentration of the hydrolyzed tyrosine amino acid is measured by using an ultraviolet spectrophotometer after the hydrolysis of the pineapple fruit leaching liquor, the enzyme activity of the leaching liquor of unit volume at different temperatures is calculated, the stability of the enzyme in the leaching liquor is represented by the total enzyme activity recovery rate, and the enzyme activity recovery rate (y)% = [ the enzyme activity of the leaching liquor of unit volume/the enzyme activity of the initial reference leaching liquor of unit volume after the condition is changed ] × 100%.
| 15℃ | 30℃ | 45℃ | 60℃ | 75℃ | |
| Comparison group (1) | 93.3% | 93.2% | 93.1% | 93.0% | 93.0% |
| Comparison group 2 | 92.7% | 91.0% | 85.7% | 77.1% | 63.2% |
From the data in the above table, it can be seen that the activity of bromelain contained in the pineapple fruit leaching solution of the control group (i) tends to be stable all the time, while the activity of bromelain contained in the pineapple fruit leaching solution of the control group (ii) gradually decreases with the increase of temperature, so that the activity of bromelain can be effectively improved by adding glucose.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (8)
1. The medicine for treating urinary calculus is characterized by comprising the following raw materials in parts by weight: 15-25 parts of radish seed, 15-23 parts of cluster mallow seed, 5-15 parts of loranthus parasiticus, 10-15 parts of curcuma zedoary, 15-25 parts of lysimachia christinae hance, 10-20 parts of spina gleditsiae, 10-20 parts of pseudo-ginseng powder, 5-10 parts of prepared myrrh, 10-15 parts of raw fleece-flower root, 10-20 parts of gentian scabra bunge, 5-10 parts of cornu cervi degelatinatum, 10-15 parts of raw acorus calamus, 10-20 parts of licorice root tip, 5-15 parts of fructus aurantii, 3-9 parts of pericarpium citri reticulatae viride, 5-13 parts of plantain herb, 10-20 parts of potassium citrate, 10-16 parts of tiopronin, 10-15 parts of allopurinol and 15-20;
the antibacterial pineapple juice beverage further comprises 13-20 parts of antibacterial extracting solution and 15-20 parts of pineapple fruit leaching solution.
2. The medicine for treating urinary calculus according to claim 1, wherein the bacteriostatic extracting solution is prepared from houttuynia cordata, sorbic acid, rhubarb, Chinese holly and groundsel.
3. The medicine for treating urinary calculus according to claim 2, wherein the preparation method of the bacteriostatic extracting solution comprises the following steps: drying and crushing houttuynia cordata, sorbic acid, rheum officinale, Chinese holly and groundsel, extracting the dried and crushed houttuynia cordata, sorbic acid, rheum officinale, Chinese holly and groundsel for 4 days at normal temperature respectively to obtain five extracting solutions, mixing and centrifuging the four extracting solutions, distilling the four extracting solutions at 50 ℃ under reduced pressure, evaporating alcohol in the extracting solutions, and then fixing the volume to 1g/mL by using distilled water to obtain the antibacterial extracting solution.
4. The drug for treating urinary calculi as claimed in claim 1, wherein the pineapple fruit extract is prepared from bromelain, glucose and ginger, garlic and onion.
5. The medicine for treating urinary calculus according to claim 4, wherein the pineapple fruit extract is prepared by the following steps:
the method comprises the following steps: cleaning ginger, garlic and onion, cutting into sections, adding water, cooking for 15-25 minutes, and collecting cooled juice;
step two: mixing bromelain and glucose, pouring the collected juice, and stirring to obtain pineapple fruit extract.
6. The preparation method of the medicine for treating urinary calculus is characterized by comprising the following steps:
s1, weighing the medicinal materials according to the amount, adding an appropriate amount of water for decocting and extracting for the first time, decocting for 1.5-2.5 hours, filtering out the liquid medicine for later use, adding an appropriate amount of water for continuous decocting for 1-1.2 hours for the second time, filtering out the liquid medicine for later use, adding an appropriate amount of water for continuous decocting for 0.8-1.2 hours for the third time, and filtering out the liquid medicine for later use;
s2, combining the liquid medicines decocted for three times in the step S1, filtering, collecting filtrate, concentrating the filtrate, and centrifuging at the rotating speed of 2700-3300 r/min to obtain centrifugate;
s3, adding appropriate amount of sucrose and essence into the centrifugate, mixing, sterilizing, and bottling to obtain medicinal liquid.
7. The method for preparing a medicine for treating urinary calculus according to claim 6, wherein the amount of water added in the first time in S1 is 8-10 times of the total weight of the medicinal materials, and the amount of water added in the second time and the third time is 6-8 times of the total weight of the medicinal materials.
8. The method for preparing a medicine for treating urinary calculus according to claim 6, wherein the filtrate obtained in S2 is concentrated to have a relative density of 1-1.2 at 60 ℃.
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