CN112546093A - Slightly soluble gum plant essential oil for preventing and treating poultry respiratory diseases - Google Patents
Slightly soluble gum plant essential oil for preventing and treating poultry respiratory diseases Download PDFInfo
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Abstract
The invention discloses a slightly soluble gum plant essential oil for preventing and treating respiratory diseases of poultry, which comprises the following components in parts by weight: 20-30 parts of eucalyptus essential oil, 5-10 parts of oregano oil, 2-5 parts of platycodon grandiflorum oil, 1-2 parts of peppermint oil, 10-30 parts of propylene glycol, 10-30 parts of polyethylene glycol and 0.002-0.006 part of surfactant. The slightly soluble glue composite plant essential oil with high essential oil content and stable property is obtained by extracting various oil-containing pure plants, scientific compatibility and proportioning optimization and adopting a specific preparation method, is used for improving the immunity of poultry and preventing and treating the respiratory diseases of the poultry, and has the advantages of obvious effect, no toxic or side effect, no residue and safe use.
Description
Technical Field
The invention relates to the technical field of livestock breeding, in particular to slightly soluble gum plant essential oil for preventing and treating respiratory diseases of poultry.
Background
With the rapid development of animal husbandry, in a high-density breeding environment, in order to reduce the occurrence of diseases, the greatest benefit is pursued, so that the application of veterinary antibiotics in animal husbandry is very wide. The use of antibiotics in large dose in the culture process can increase the burden of the liver and the kidney, damage the nervous system and increase the residual quantity of antibiotics in meat products and agricultural byproducts. In the past, the generation of drug resistance can bring serious consequences to livestock and poultry, aggravate the difficulty of disease treatment and cause the pollution of ecological environment. Antibiotics in livestock and poultry bodies are discharged to the outside of the body in the modes of excrement, urine and the like through a series of metabolic processes of the body, and air pollution can be caused to a certain extent. The excrement, waste water and waste material of livestock and poultry are directly discharged into rivers and soil without being filtered, so that water and soil pollution is caused, and the original pH value is unbalanced.
Poultry of all ages and varieties are susceptible to respiratory diseases, generally expressed as decreased laying rate, decreased egg weight, poor eggshell quality, hindered reproductive system development, decreased uniformity, delayed laying, and after incidence of young meat poultry, in addition to weight loss and increased feed-meat ratio, decreased carcass quality and greatly increased mortality rate are caused, thus bringing huge loss to production. The plant essential oil has antibacterial, insecticidal, antioxidant, etc. activity, and can be widely used in medicine, pesticide, feed additive, food preservation, etc. Therefore, the development of the plant essential oil preparation with good stability and for preventing and treating the respiratory diseases of the poultry has important significance.
Disclosure of Invention
In order to solve the problems in the prior art, the invention provides the slightly soluble plant essential oil for preventing and treating the respiratory diseases of the poultry.
The purpose of the invention is realized by the following technical scheme:
the slightly soluble gum plant essential oil for preventing and treating the respiratory diseases of poultry comprises the following components in parts by weight: 20-30 parts of eucalyptus essential oil, 5-10 parts of oregano oil, 2-5 parts of platycodon grandiflorum oil, 1-2 parts of peppermint oil, 10-30 parts of propylene glycol, 10-30 parts of polyethylene glycol and 0.002-0.006 part of surfactant.
The slightly soluble gum plant essential oil for preventing and treating the respiratory diseases of poultry comprises the following components in parts by weight: 25 parts of eucalyptus essential oil, 8 parts of oregano oil, 4 parts of platycodon grandiflorum oil, 1.5 parts of peppermint oil, 20 parts of propylene glycol, 20 parts of polyethylene glycol and 0.004 part of surfactant.
Further, the polyethylene glycol is polyethylene glycol 400.
Further, the weight part ratio of the propylene glycol to the polyethylene glycol 400 is 1: 1.
Further, the surfactant is one or more of phosphatidyl glycerol, soybean phospholipid, cetyl alcohol and tyloxapol.
A preparation method of sparingly soluble plant essential oil for preventing and treating poultry respiratory diseases comprises the following steps:
step one, at room temperature, mixing eucalyptus essential oil, oregano oil, platycodon grandiflorum oil and peppermint oil according to a ratio and a surfactant according to a corresponding ratio uniformly, and performing ultrasonic treatment for 20-40 s to obtain a nano emulsion;
and step two, uniformly mixing propylene glycol and polyethylene glycol 400 in proportion, dropwise adding the nano emulsion prepared in the step one into the nano emulsion under magnetic stirring, and continuously stirring for 3-6 min to obtain uniform and stable micro sol.
The invention provides the application of the slightly soluble gum plant essential oil for preventing and treating the respiratory diseases of poultry in the aspects of preventing and treating the respiratory diseases of the poultry.
The slightly soluble gum plant essential oil for preventing and treating the respiratory diseases of the poultry is applied by spraying, and is added into drinking water or feed for administration.
The pharmacology and the function of each component used in the invention are as follows:
eucalyptus essential oil: eucalyptus essential oil is a complex mixture of various monoterpenes, sesquiterpenes, aromatic phenols, oxides, ethers, alcohols, esters, aldehydes, ketones, has effects of resisting various bacteria, especially against upper respiratory tract infection and chronic bronchitis, and also has expectorant effect, and can be used for certain skin diseases, and as a irrigant for wound surface, ulcer and fistula.
Origanum oil: the oregano oil mainly comprises carvacrol and thymol. The origanum oil has the functions of sterilization, bacteriostasis and oxidation resistance, has strong surface activity and fat solubility, can quickly penetrate through the cell membrane of pathogenic microorganism, enables the cell content to be lost, prevents mitochondria from absorbing oxygen to achieve the purposes of bacteriostasis, antibiosis and sterilization, simultaneously has the function of oxidation resistance, and can enhance the immune function of animals.
Platycodon root oil: the platycodon oil is fatty oil obtained by squeezing or extracting dried and mature platycodon fruits, and contains various amino acids, various trace elements necessary for human bodies, linoleic acid, platycodin, platycodon polysaccharide, flavonoid glycoside, limonene, vitamins and the like. The radix Platycodi essential oil has effects of eliminating phlegm, discharging pus, resisting inflammation, and resisting oxidation.
Peppermint oil: pungent flavor can disperse, cool can clear heat, clear and cool can be used as the common herb for dispelling wind-heat, so it can be used for treating wind-heat type common cold or warm disease at the beginning.
Propylene glycol: the propylene glycol is colorless and odorless liquid, has good viscosity and hygroscopicity, can be used as medicinal adjuvant solvent, has good intersolubility with essential oil, and stable property, and can prevent essential oil from volatilizing.
Polyethylene glycol 400: is colorless or nearly colorless viscous liquid, and can be used as pharmaceutical adjuvant solvent.
According to the invention, the propylene glycol and the polyethylene glycol 400 are compounded, so that the propylene glycol and the polyethylene glycol 400 can act with a nano emulsion formed by mixing essential oil and a surfactant to generate a micro-sol, the micro-sol has long-term stability and can reduce volatilization of the essential oil, and the propylene glycol and the polyethylene glycol 400 also have good moisture absorption and moisture retention effects and reduce irritation of the essential oil to respiratory tracts.
Compared with the prior art, the invention has the following beneficial effects:
(1) the slightly soluble glue composite plant essential oil with high essential oil content and stable property is obtained by extracting various oil-containing pure plants, scientific compatibility and proportioning optimization and adopting a specific preparation method, is used for improving the immunity of poultry and preventing and treating the respiratory diseases of the poultry, and has the advantages of obvious effect, no toxic or side effect, no residue and safe use.
(2) The slightly soluble gum plant essential oil for preventing and treating the respiratory diseases of the poultry is scientific compatibility obtained by combining a large number of experiments on the basis of Chinese and western medicine theories, and can realize synergistic effect by optimizing the proportion of the components.
(3) The preparation method of the slightly soluble plant essential oil provided by the invention comprises the steps of firstly mixing the essential oil component with the surfactant to promote the emulsification of the essential oil, obtaining nano emulsion after ultrasonic treatment, and then dropwise adding the nano emulsion into the mixed solution of propylene glycol and polyethylene glycol 400 to prepare uniform and stable slightly soluble glue, wherein the slightly soluble glue has good stability in the air, water and feed, so that the use mode is more flexible.
Detailed Description
To further illustrate the technical measures taken by the present invention and the effects thereof, the following detailed description is given with reference to preferred embodiments of the present invention.
Example 1
The slightly soluble gum plant essential oil for preventing and treating the respiratory diseases of poultry comprises the following components in parts by weight: 20 parts of eucalyptus essential oil, 5 parts of oregano oil, 2 parts of platycodon grandiflorum oil, 1 part of peppermint oil, 10 parts of propylene glycol, 10 parts of polyethylene glycol 40010 parts and 0.002 part of phosphatidyl glycerol.
The preparation method of the slightly soluble gum plant essential oil comprises the following steps:
step one, at room temperature, taking eucalyptus essential oil, oregano oil, platycodon grandiflorum oil and peppermint oil according to the proportion, uniformly mixing the eucalyptus essential oil, the oregano oil, the platycodon grandiflorum oil and the peppermint oil with phosphatidyl glycerol in the corresponding proportion, and carrying out ultrasonic treatment for 20s to obtain a nano emulsion;
and step two, uniformly mixing propylene glycol and polyethylene glycol 400 in proportion, dropwise adding the nano emulsion prepared in the step one into the nano emulsion under magnetic stirring, and continuously stirring for 3min to obtain uniform and stable micro sol.
Example 2
The slightly soluble gum plant essential oil for preventing and treating the respiratory diseases of poultry comprises the following components in parts by weight: 25 parts of eucalyptus essential oil, 8 parts of oregano oil, 4 parts of platycodon grandiflorum oil, 1.5 parts of peppermint oil, 20 parts of propylene glycol, 20 parts of polyethylene glycol 40020 parts and 0.004 part of soybean lecithin.
The preparation method of the slightly soluble gum plant essential oil comprises the following steps:
step one, at room temperature, mixing eucalyptus essential oil, oregano oil, platycodon grandiflorum oil and peppermint oil according to the proportion with soybean lecithin in a corresponding proportion uniformly, and performing ultrasonic treatment for 30s to obtain a nano emulsion;
and step two, uniformly mixing propylene glycol and polyethylene glycol 400 in proportion, dropwise adding the nano emulsion prepared in the step one into the nano emulsion under magnetic stirring, and continuously stirring for 5min to obtain uniform and stable micro sol.
Example 3
The slightly soluble gum plant essential oil for preventing and treating the respiratory diseases of poultry comprises the following components in parts by weight: 30 parts of eucalyptus essential oil, 10 parts of oregano oil, 5 parts of platycodon grandiflorum oil, 2 parts of peppermint oil, 30 parts of propylene glycol, 30 parts of polyethylene glycol 40030 parts, 0.002 part of hexadecanol and 0.004 part of tyloxapol.
The preparation method of the slightly soluble gum plant essential oil comprises the following steps:
step one, at room temperature, taking eucalyptus essential oil, oregano oil, platycodon root oil and peppermint oil according to the proportion, uniformly mixing the eucalyptus essential oil, the oregano oil, the platycodon root oil and the peppermint oil with hexadecanol according to the corresponding proportion, and carrying out ultrasonic treatment for 40s to obtain nano emulsion;
and step two, uniformly mixing propylene glycol and polyethylene glycol 400 in proportion, dropwise adding the nano emulsion prepared in the step one into the nano emulsion under magnetic stirring, and continuously stirring for 6min to obtain uniform and stable micro sol.
Comparative example 1
Except for the platycodon root oil of 0 part, 1 part, 6 parts and 7 parts by weight, the rest of the preparation method is the same as the embodiment 2, and the prepared slightly soluble gum plant essential oil is numbered from A to D in sequence.
Comparative example 2
The procedure is as in example 2 except that no surfactant is included.
Comparative example 3
The same as example 2 except that the ratio of propylene glycol to polyethylene glycol is 3:1 in 400 parts by weight.
Comparative example 4
The same as example 2 except that the ratio of propylene glycol to polyethylene glycol is 2:1 in parts by weight.
Comparative example 5
The same as example 2 except that the ratio of propylene glycol to polyethylene glycol is 1:2 in parts by weight.
Comparative example 6
The same as example 2 except that the ratio of propylene glycol to polyethylene glycol is 1:3 in parts by weight.
Product stability testing
The slightly soluble plant essential oils prepared in examples 1 to 3 and comparative examples 2 to 6 were respectively allowed to stand at room temperature for 60 days, and the conditions of phase separation and particle size change of the slightly soluble plant essential oils were observed, and the experimental results are shown in table 1 below.
TABLE 1
As can be seen from table 1, the slightly soluble plant essential oils prepared in examples 1 to 3 have no phase separation and no change in particle size after being placed at room temperature for 60 days, which indicates that the slightly soluble plant essential oil provided by the present invention has a stable state and can be stably stored for a long time. Comparative example 2 shows phase separation and particle size enlargement after standing at room temperature for 60 days, which indicates that the surfactant used in the present invention plays an important role in maintaining the stability of the sparingly soluble glue; although no phase separation occurs after the comparative examples 3-4 are placed at room temperature for 60 days, the particle size is obviously increased, and the comparative examples 5-6 are placed at room temperature for 60 days, the phenomena of phase separation and particle size increase occur, which shows that the 400 parts by weight of the propylene glycol and the polyethylene glycol have important influence on the stability of the micro-sol plant essential oil.
Examples of the applications
300 white feather broilers with the same age in days, similar weight and good health condition are selected and randomly divided into 6 groups of 50 broilers, the feeding conditions and the management method of each group are the same, and the difference is that: feeding normal feed and drinking water to the blank control group; test group 1 the slightly soluble plant essential oil A prepared in comparative example 1 was added with water at a ratio of 1: 1000; test group 2 the slightly soluble plant essential oil B prepared in comparative example 1 was added with water at a ratio of 1: 1000; test group 3 the slightly soluble plant essential oil prepared in example 2 was added to water at a ratio of 1: 1000; test group 4 the slightly soluble plant essential oil C prepared in comparative example 1 was added with water at a ratio of 1: 1000; test group 5 the sparingly soluble plant essential oil D prepared in comparative example 1 was added to water at a ratio of 1: 1000. And counting the incidence of respiratory diseases of each group and the natural cure rate of the affected individuals within 20 days. The results are shown in table 2 below:
TABLE 2
| Infectious conditions | Blank control group | Test group 1 | Test group 2 | Test group 3 | Test group 4 | Test group 5 |
| Incidence (%) | 48 | 24 | 18 | 4 | 30 | 36 |
| Natural recovery rate (%) | 16.7 | 58.3 | 66.7 | 100 | 46.7 | 44.4 |
As can be seen from table 2, the slightly soluble plant essential oil prepared in embodiments 1 to 3 of the present invention has a good effect on preventing and treating respiratory diseases of poultry, and the obtained effect is related to the ratio of the platycodon grandiflorum oil in the formulation.
In conclusion, the slightly soluble plant essential oil provided by the invention has good stability, can be stably stored for a long time, has a synergistic effect among components, and has remarkable prevention and treatment effects on poultry respiratory diseases.
The above description is only for the specific embodiment of the present invention, but the protection scope of the present invention is not limited thereto, and other modifications or equivalent substitutions made by the technical solution of the present invention by the ordinary skilled in the art should be covered within the scope of the claims of the present invention without departing from the spirit and scope of the technical solution of the present invention.
Claims (7)
1. The slightly soluble gum plant essential oil for preventing and treating respiratory diseases of poultry is characterized by comprising the following components in parts by weight: 20-30 parts of eucalyptus essential oil, 5-10 parts of oregano oil, 2-5 parts of platycodon grandiflorum oil, 1-2 parts of peppermint oil, 10-30 parts of propylene glycol, 10-30 parts of polyethylene glycol and 0.002-0.006 part of surfactant.
2. The sparingly soluble plant essential oil for preventing and treating respiratory diseases of poultry according to claim 1, comprising the following components in parts by weight: 25 parts of eucalyptus essential oil, 8 parts of oregano oil, 4 parts of platycodon grandiflorum oil, 1.5 parts of peppermint oil, 20 parts of propylene glycol, 20 parts of polyethylene glycol and 0.004 part of surfactant.
3. The sparingly soluble plant essential oil for prevention and treatment of poultry respiratory diseases in accordance with claim 1, wherein said polyethylene glycol is polyethylene glycol 400.
4. The sparingly soluble plant essential oil for preventing and treating poultry respiratory diseases according to claim 1, wherein the ratio of propylene glycol to polyethylene glycol 400 is 1:1 by weight.
5. The sparingly soluble plant essential oil for prevention and treatment of poultry respiratory diseases in accordance with claim 1, wherein said surfactant is one or more of phosphatidylglycerol, soybean phospholipids, cetyl alcohol, tyloxapol.
6. The preparation method of the sparingly soluble plant essential oil for preventing and treating respiratory diseases of poultry according to any one of claims 1 to 5, comprising the steps of:
step one, at room temperature, mixing eucalyptus essential oil, oregano oil, platycodon grandiflorum oil and peppermint oil according to a ratio and a surfactant according to a corresponding ratio uniformly, and performing ultrasonic treatment for 20-40 s to obtain a nano emulsion;
and step two, uniformly mixing propylene glycol and polyethylene glycol 400 in proportion, dropwise adding the nano emulsion prepared in the step one into the nano emulsion under magnetic stirring, and continuously stirring for 3-6 min to obtain uniform and stable micro sol.
7. The use of the sparingly-soluble plant essential oil for the prevention and treatment of respiratory diseases in poultry according to any one of claims 1 to 5 for the prevention and treatment of respiratory diseases in poultry.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104069266A (en) * | 2013-03-27 | 2014-10-01 | 烟台绿叶动物保健品有限公司 | Plant essential oil composition for veterinary use |
| CN107929394A (en) * | 2018-01-17 | 2018-04-20 | 信阳农林学院 | A kind of oral administration solid self-emulsifying dispersion for treating livestock and birds respiratory disease |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104069266A (en) * | 2013-03-27 | 2014-10-01 | 烟台绿叶动物保健品有限公司 | Plant essential oil composition for veterinary use |
| CN107929394A (en) * | 2018-01-17 | 2018-04-20 | 信阳农林学院 | A kind of oral administration solid self-emulsifying dispersion for treating livestock and birds respiratory disease |
Non-Patent Citations (2)
| Title |
|---|
| 司红彬: "牛至油在养禽业的应用潜力", 《养禽与禽病防治》 * |
| 潘卫三: "《工业药剂学》", 31 August 2015, 中国医药科技出版社 * |
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