CN112512533A - 用于治疗癌症的材料与方法 - Google Patents

用于治疗癌症的材料与方法 Download PDF

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CN112512533A
CN112512533A CN201980046671.2A CN201980046671A CN112512533A CN 112512533 A CN112512533 A CN 112512533A CN 201980046671 A CN201980046671 A CN 201980046671A CN 112512533 A CN112512533 A CN 112512533A
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cells
csf
nucleic acid
cell
polypeptide
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Chinese (zh)
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S·J·肯德里安
R·M·斯特纳
M·J·考克斯
R·坂村
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Miaoyou Medical Education Research Foundation
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Miaoyou Medical Education Research Foundation
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
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    • C12N5/0636—T lymphocytes
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
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    • A61K40/4224—Molecules with a "CD" designation not provided for elsewhere
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P35/02—Antineoplastic agents specific for leukemia
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    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
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    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • A—HUMAN NECESSITIES
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CN201980046671.2A 2018-06-01 2019-05-31 用于治疗癌症的材料与方法 Pending CN112512533A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862679348P 2018-06-01 2018-06-01
US62/679,348 2018-06-01
US201862753485P 2018-10-31 2018-10-31
US62/753,485 2018-10-31
PCT/US2019/034900 WO2019232370A1 (en) 2018-06-01 2019-05-31 Materials and methods for treating cancer

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CN112512533A true CN112512533A (zh) 2021-03-16

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US (1) US20210214723A1 (https=)
EP (1) EP3801563B1 (https=)
JP (1) JP7411578B2 (https=)
KR (1) KR20210020946A (https=)
CN (1) CN112512533A (https=)
AU (1) AU2019277660A1 (https=)
BR (1) BR112020024601A2 (https=)
CA (1) CA3101991A1 (https=)
ES (1) ES2959645T3 (https=)
MX (1) MX2020013017A (https=)
WO (1) WO2019232370A1 (https=)

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EP3691663A4 (en) 2017-10-02 2021-08-18 Humanigen, Inc. METHODS OF TREATMENT OF TOXICITY ASSOCIATED WITH IMMUNOTHERAPIES USING A GM-CSF ANTAGONIST
US11130805B2 (en) 2017-10-02 2021-09-28 Humanigen, Inc. Methods of treating CART-T cell therapy-induced neuroinflammation using a GM-CSF antagonist
US10899831B2 (en) 2017-10-02 2021-01-26 Humanigen, Inc. Method of reducing the level of non-GM-CSF cytokines/chemokines in immunotherapy-related toxicity
US10927168B2 (en) 2017-10-02 2021-02-23 Humanicen, Inc. Method of reducing tumor relapse rate in immunotherapy by administration of lenzilumab
SG11202102317PA (en) * 2018-09-10 2021-04-29 Humanigen Inc Methods of treating immunotherapy-related toxicity using a gm-csf antagonist
US12264189B2 (en) 2018-10-31 2025-04-01 Mayo Foundation For Medical Education And Research Methods and materials for treating cancer
SG11202103589XA (en) * 2018-10-31 2021-05-28 Humanigen Inc Materials and methods for treating cancer
WO2020092736A1 (en) 2018-10-31 2020-05-07 Mayo Foundation For Medical Education And Research Methods and materials for treating cancer
CN113088540B (zh) * 2020-01-08 2024-12-06 上海交通大学医学院附属瑞金医院 一种gm-csf敲低的t细胞及其用途
JP2023542539A (ja) * 2020-09-24 2023-10-10 ザ ジャクソン ラボラトリー 免疫細胞療法を評価するためのヒト化マウスモデル
CN114934071B (zh) * 2021-04-30 2023-10-17 四川大学华西医院 一种表达免疫调节因子的car载体及其应用

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WO2015066262A1 (en) * 2013-11-04 2015-05-07 Trustees Of Dartmouth College Methods for preventing toxicity of adoptive cell therapy
WO2017059796A1 (en) * 2015-10-08 2017-04-13 Shanghai Sidansai Biotechnology Co., Ltd Activation and expansion of t cells
CN107746831A (zh) * 2017-11-07 2018-03-02 南京北恒生物科技有限公司 具有化疗药物抗性的通用型cart/tcrt细胞及其构建方法

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UY35468A (es) * 2013-03-16 2014-10-31 Novartis Ag Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19
CN116850305A (zh) * 2016-05-06 2023-10-10 朱诺治疗学股份有限公司 基因工程化细胞及其制备方法

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WO2014011984A1 (en) * 2012-07-13 2014-01-16 The Trustees Of The University Of Pennsylvania Toxicity management for anti-tumor activity of cars
WO2015066262A1 (en) * 2013-11-04 2015-05-07 Trustees Of Dartmouth College Methods for preventing toxicity of adoptive cell therapy
WO2017059796A1 (en) * 2015-10-08 2017-04-13 Shanghai Sidansai Biotechnology Co., Ltd Activation and expansion of t cells
CN107746831A (zh) * 2017-11-07 2018-03-02 南京北恒生物科技有限公司 具有化疗药物抗性的通用型cart/tcrt细胞及其构建方法

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MX2020013017A (es) 2021-03-02
EP3801563A4 (en) 2022-05-11
KR20210020946A (ko) 2021-02-24
US20210214723A1 (en) 2021-07-15
AU2019277660A1 (en) 2021-01-21
WO2019232370A1 (en) 2019-12-05
CA3101991A1 (en) 2019-12-05
BR112020024601A2 (pt) 2021-04-06
ES2959645T3 (es) 2024-02-27
EP3801563A1 (en) 2021-04-14
EP3801563B1 (en) 2023-07-12
JP2021525519A (ja) 2021-09-27

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