CN112512504A - 一种水凝胶、含其的药物组合物及其应用 - Google Patents

一种水凝胶、含其的药物组合物及其应用 Download PDF

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Publication number
CN112512504A
CN112512504A CN201880094459.9A CN201880094459A CN112512504A CN 112512504 A CN112512504 A CN 112512504A CN 201880094459 A CN201880094459 A CN 201880094459A CN 112512504 A CN112512504 A CN 112512504A
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China
Prior art keywords
hydrogel
fgf
kgf
poloxamer
glycerol
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CN201880094459.9A
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English (en)
Inventor
王晓杰
李校堃
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Wenzhou Medical University
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Wenzhou Medical University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)

Abstract

一种用于治疗糖尿病并发损伤的温敏型水凝胶，其包括KGF‑2、FGF‑21、泊洛沙姆407、肝素钠、甘油和水。该水凝胶特别适合在该损伤治疗初期使用。另外，还提供了用于制备该水凝胶的辅料组合物等。

Description

PCT国内申请，说明书已公开。

Claims (12)

  1. PCT国内申请，权利要求书已公开。
CN201880094459.9A 2018-06-22 2018-06-22 一种水凝胶、含其的药物组合物及其应用 Pending CN112512504A (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2018/092325 WO2019241985A1 (zh) 2018-06-22 2018-06-22 一种水凝胶、含其的药物组合物及其应用

Publications (1)

Publication Number Publication Date
CN112512504A true CN112512504A (zh) 2021-03-16

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CN201880094459.9A Pending CN112512504A (zh) 2018-06-22 2018-06-22 一种水凝胶、含其的药物组合物及其应用

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CN (1) CN112512504A (zh)
WO (1) WO2019241985A1 (zh)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113633756A (zh) * 2021-06-17 2021-11-12 温州医科大学 Fgf21温敏缓释载体和基因修饰方法以及其制备方法
CN114617839A (zh) * 2022-03-31 2022-06-14 温州医科大学 治疗冻结性冷损伤的凝胶搽剂及其制备方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1283997A (zh) * 1997-12-22 2001-02-14 人类基因组科学公司 角质形成细胞生长因子－2制剂
CN1984673A (zh) * 2004-05-17 2007-06-20 阿雷斯贸易股份有限公司 干扰素水凝胶制剂
CN101143212A (zh) * 2006-09-13 2008-03-19 广州暨南大学医药生物技术研究开发中心 重组人酸性成纤维细胞生长因子温敏型凝胶剂及其制备方法
CN104188894A (zh) * 2014-08-11 2014-12-10 吉林大学 布替萘芬温敏凝胶制剂及其制备方法
CN104258456A (zh) * 2014-08-29 2015-01-07 华南理工大学 一种含六方介孔硅的创面修复凝胶及其制备方法
CN108187132A (zh) * 2018-01-05 2018-06-22 广州润虹医药科技股份有限公司 一种聚维酮碘水凝胶抗菌敷料及其制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003500456A (ja) * 1999-06-02 2003-01-07 ヒューマン・ジェノム・サイエンシズ・インコーポレイテッド 角質細胞増殖因子−２製剤

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1283997A (zh) * 1997-12-22 2001-02-14 人类基因组科学公司 角质形成细胞生长因子－2制剂
CN1984673A (zh) * 2004-05-17 2007-06-20 阿雷斯贸易股份有限公司 干扰素水凝胶制剂
CN101143212A (zh) * 2006-09-13 2008-03-19 广州暨南大学医药生物技术研究开发中心 重组人酸性成纤维细胞生长因子温敏型凝胶剂及其制备方法
CN104188894A (zh) * 2014-08-11 2014-12-10 吉林大学 布替萘芬温敏凝胶制剂及其制备方法
CN104258456A (zh) * 2014-08-29 2015-01-07 华南理工大学 一种含六方介孔硅的创面修复凝胶及其制备方法
CN108187132A (zh) * 2018-01-05 2018-06-22 广州润虹医药科技股份有限公司 一种聚维酮碘水凝胶抗菌敷料及其制备方法

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BYEONGMOON JEONG等: "Thermosensitive sol–gel reversible hydrogels" *
JAE HYUP LEE等: "The Effect of Poloxamer 407-Based Hydrogel on the Osteoinductivity of Demineralized Bone Matrix" *
杨选鑫等: "rh-aFGF 卡波姆 940 凝胶对 1 型糖尿病大鼠皮肤创伤的修复作用" *
王丽娟等: "泊洛沙姆407温度敏感型原位凝胶的研究进展" *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113633756A (zh) * 2021-06-17 2021-11-12 温州医科大学 Fgf21温敏缓释载体和基因修饰方法以及其制备方法
CN114617839A (zh) * 2022-03-31 2022-06-14 温州医科大学 治疗冻结性冷损伤的凝胶搽剂及其制备方法
CN114617839B (zh) * 2022-03-31 2023-07-07 温州医科大学 治疗冻结性冷损伤的凝胶搽剂及其制备方法

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