CN1125077C - 1,3,5(10)－雌三烯的氨基磺酸酯衍生物、其制备方法和含有这些化合物的药物 - Google Patents

1,3,5(10)－雌三烯的氨基磺酸酯衍生物、其制备方法和含有这些化合物的药物 Download PDF

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Publication number
CN1125077C
CN1125077C CN96197673A CN96197673A CN1125077C CN 1125077 C CN1125077 C CN 1125077C CN 96197673 A CN96197673 A CN 96197673A CN 96197673 A CN96197673 A CN 96197673A CN 1125077 C CN1125077 C CN 1125077C
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CN
China
Prior art keywords
hydrogen atom
acid
sulfamate
derivatives
independently
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN96197673A
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English (en)
Chinese (zh)
Other versions
CN1200126A (zh
Inventor
S·施沃兹
W·埃尔杰
G·里德森
B·施奈德
I·塞姆
M·里克特
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Bayer Pharma AG
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Jenapharm GmbH and Co KG
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Publication date
Application filed by Jenapharm GmbH and Co KG filed Critical Jenapharm GmbH and Co KG
Publication of CN1200126A publication Critical patent/CN1200126A/zh
Application granted granted Critical
Publication of CN1125077C publication Critical patent/CN1125077C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN96197673A 1995-10-19 1996-09-19 1,3,5(10)－雌三烯的氨基磺酸酯衍生物、其制备方法和含有这些化合物的药物 Expired - Fee Related CN1125077C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19540233.2 1995-10-19
DE19540233A DE19540233B4 (de) 1995-10-19 1995-10-19 Sulfamat-Derivate von 1,3,5(10)-Estratrien-Derivaten, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen

Publications (2)

Publication Number Publication Date
CN1200126A CN1200126A (zh) 1998-11-25
CN1125077C true CN1125077C (zh) 2003-10-22

Family

ID=7776061

Family Applications (1)

Application Number Title Priority Date Filing Date
CN96197673A Expired - Fee Related CN1125077C (zh) 1995-10-19 1996-09-19 1,3,5(10)－雌三烯的氨基磺酸酯衍生物、其制备方法和含有这些化合物的药物

Country Status (13)

Country Link
EP (1) EP0862577B1 (de)
JP (2) JPH11505268A (de)
KR (1) KR100306044B1 (de)
CN (1) CN1125077C (de)
AT (1) ATE178903T1 (de)
AU (1) AU1436097A (de)
BR (1) BR9610905A (de)
DE (2) DE19540233B4 (de)
DK (1) DK0862577T3 (de)
ES (1) ES2131972T3 (de)
GR (1) GR3030733T3 (de)
RU (1) RU2159774C2 (de)
WO (1) WO1997014712A2 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999064013A1 (en) * 1998-06-10 1999-12-16 Sterix Limited Pharmaceutical composition with tumor necrosis factor a and 2-methoxyestrone-3-o-sulphamate for inhibition of estrone sulphatase
DE19712488A1 (de) 1997-03-25 1998-10-01 Knoell Hans Forschung Ev Steroidsulfamate, Verfahren zu ihrer Herstellung und Anwendung derselben
US6288050B1 (en) * 1997-07-18 2001-09-11 Duquesne University Of The Holy Ghost Steroid sulfatase inhibitors and methods for making and using the same
US6248780B1 (en) 1998-10-01 2001-06-19 Duquesne University Of The Holy Ghost Compounds for the treatment of estrogen-dependent illnesses and methods for making and using the same
DE19943708B4 (de) * 1999-09-08 2007-12-20 Bayer Schering Pharma Ag Neue C13-substituierte Estra-1,3,5(10)-trien-3-yl-sulfamate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
US6583130B1 (en) 1999-09-13 2003-06-24 Schering Ag C13-substituted estra-1,3,5,(10)-trien-3-yl sulfamates, methods of preparing same, and pharmaceutical compositions containing these compounds
EP1769799A3 (de) * 2000-01-14 2010-01-13 Sterix Limited Pharmazeutische Zusammensetzung, welche steroidische Strukturen enthalten, und deren Verwendungen
DE10027887A1 (de) * 2000-05-31 2001-12-13 Jenapharm Gmbh Verbindungen mit einer Sulfonamidgruppe und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
DE10139494A1 (de) * 2001-08-13 2003-03-06 Jenapharm Gmbh Antitumor wirksame 2-Alkoxyestradiolsulfamate
US8026229B2 (en) 2001-08-13 2011-09-27 Sterix Limited Antitumor-active 2-alkoxyestradiol sulfamates
DE10307105A1 (de) * 2003-02-19 2004-09-09 Schering Ag Antitumor wirksame 2-substituierte 18a-Homoestra-1,3,5(10)-trien-3-yl sulfamate
DE10307104A1 (de) * 2003-02-19 2004-09-23 Schering Ag Antitumor wirksame 2-substituierte Estra-1,3,5(10)-trien-3-yl sulfamate
DE10307103A1 (de) * 2003-02-19 2004-09-09 Schering Ag Antitumor wirksame 2-substituierte D-Homostra-1,3,5(10)-trien-3-yl sulfamate
US7534780B2 (en) 2004-05-21 2009-05-19 Bayer Schering Pharma Aktiengesellschaft Estradiol prodrugs
US20080292765A1 (en) * 2007-05-22 2008-11-27 The Coca-Cola Company Sweetness Enhancers, Sweetness Enhanced Sweetener Compositions, Methods for Their Formulation, and Uses
GB201302368D0 (en) * 2013-02-11 2013-03-27 Univ Bath Compound
RU2562242C1 (ru) * 2014-07-10 2015-09-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Санкт-Петербургский государственный университет" (СПбГУ) РАЦЕМИЧЕСКИЙ 2,17β-ДИСУЛЬФАМОИЛОКСИ-3-МЕТОКСИ-8α-ЭСТРА-1,3,5(10)-ТРИЕН В КАЧЕСТВЕ ИНГИБИТОРА ПРОЛИФЕРАЦИИ ОПУХОЛЕВЫХ КЛЕТОК MCF-7

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1949095A1 (de) * 1968-10-04 1970-09-24 Jenapharm Veb Steroidester
FR2133484A2 (en) * 1969-04-29 1972-12-01 Jenapharm Veb 3-17 and 21-sulphonyloxy-steroids - with androgenic anabolic progestogenic and oestrogen activity of long duration

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL94183A (en) * 1989-05-05 2003-09-17 Baylor College Medicine cDNA SEQUENCE CODING FOR HUMAN LACTOFERRIN PROTEIN OR PORTION THEREOF AND LACTOFERRIN PROTEIN PRODUCED FROM SAID SEQUENCE
EP0429628B1 (de) * 1989-06-16 1998-09-02 Genencor International, Inc. Dna-sequenzen, vektoren und fusionspolypeptide zur erhöhung der sekretion gewünschter polypeptide von filamentösen fungi
JP2818056B2 (ja) * 1990-09-07 1998-10-30 森永乳業株式会社 抗菌性ペプチドおよび抗菌剤
ZA932568B (en) * 1992-04-24 1993-11-12 Baylor College Midecine A Non Production of recombinant human lactoferrin

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1949095A1 (de) * 1968-10-04 1970-09-24 Jenapharm Veb Steroidester
FR2133484A2 (en) * 1969-04-29 1972-12-01 Jenapharm Veb 3-17 and 21-sulphonyloxy-steroids - with androgenic anabolic progestogenic and oestrogen activity of long duration

Also Published As

Publication number Publication date
ES2131972T3 (es) 1999-08-01
EP0862577A2 (de) 1998-09-09
EP0862577B1 (de) 1999-04-14
DE19540233A1 (de) 1997-04-24
JPH11505268A (ja) 1999-05-18
JP3040175B2 (ja) 2000-05-08
RU2159774C2 (ru) 2000-11-27
ATE178903T1 (de) 1999-04-15
CN1200126A (zh) 1998-11-25
BR9610905A (pt) 1999-07-13
KR19990064144A (ko) 1999-07-26
DE59601683D1 (de) 1999-05-20
WO1997014712A2 (de) 1997-04-24
GR3030733T3 (en) 1999-11-30
DK0862577T3 (da) 1999-10-25
AU1436097A (en) 1997-05-07
DE19540233B4 (de) 2005-08-25
KR100306044B1 (ko) 2001-12-05
WO1997014712A3 (de) 1997-06-05

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Owner name: SCHERING AG

Free format text: FORMER OWNER: JENAPHARM GMBH

Effective date: 20031216

C41 Transfer of patent application or patent right or utility model
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Effective date of registration: 20031216

Address after: Berlin, Federal Republic of Germany

Patentee after: Schering AG

Address before: Jena, Federal Republic of Germany

Patentee before: Jenapharm GmbH

C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee