CN112472748A - 治疗白发的药物及其制备方法 - Google Patents
治疗白发的药物及其制备方法 Download PDFInfo
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Abstract
一种治疗白发的药物,包括1个中药内服方、辅以1个外洗方、1个药枕方。内服方由如下重量份的原料药制成,九蒸九晒黑芝麻10‑50份、菟丝子2‑40份、五味子2‑40份、沙苑子2‑40份、女贞子2‑40份、墨旱莲2‑40份,熟地黄3‑50份、阿胶1‑10份、人参1‑10份、茯苓3‑20份、甘草3‑20份;外洗方由如下重量份的原料药制成,制首乌2‑40份、土马鬃2‑40份、侧柏叶2‑40份、羌活2‑40份;药枕方由如下重量份的原料药制成:荞麦壳100‑3000份、当归20‑80份、党参20‑80份、黄芪20‑80份、香附20‑80份、川芎20‑80份、冰片5‑50份、甘草10‑50份。本发明的药物通过内服、外洗和药枕联合使用综合治疗,从根源出发,能够补肝肾、益精血、润肠燥、健脾运、滋胃阴、润肺生津、清热凉血、通经活络、乌须发,治疗白发效果显著,且无毒副作用。
Description
【技术领域】
本发明属于中药技术领域,具体涉及一种内服、外洗和药枕联合使用综合治疗白发的药物和制备方法。
【背景技术】
通常情况下,头发由黑变成花白,由花白又变成全白,是人逐渐步人老年阶段的一个外部特征,这是因为人体逐渐衰老,发根部位的毛乳头如同身体其他各部的器官一样,功能逐渐减弱,黑色素生产越来越少,以至全无而形成的自然变化现象。然而很多年纪尚轻,却已满头白发,这当然不会是因为身体衰老、毛乳头制造黑色素的能力减弱所致。黑发变白除了与遗传因素有关外,还与精神、营养以及内分泌等因素有关,和微循环障碍关系更为密切。由于生活节奏快、压力比较大,往往造成人们精神过度紧张和营养不良。人体精神状态的改变,长期抑郁不欢、忧思过度或情绪过度紧张、惊恐常会引起毛发迅速变白。国内还有报道认为头发早白与环境、饮食污染有关,是多种复杂因素综合作用的结果。目前,对于治疗白发的解决方式主要有:1、染发,虽然化学染发能迅速掩盖白发,但是治标不治本,常常诱发各种疾病,如接触性皮炎、白血病、骨质疏松甚至癌变等;2、植发手术,有创伤,费用高,也是治标不治本;3、药物治理,添加有药物的洗发水或者服用药物,药物洗发水只从外部对发质进行处理,治标不治本;目前现有的口服型药物,效果不明显,疗效差,但真正能解决随年龄增长而不可避免产生的白发问题的技术和产品还是比较少。使用中医药有标本兼治的作用,在治疗白发方面有着明显的优势。申请人本人因久受白发之苦,一直致力于研究白发的治疗,先后与老中医张书信(山东莘县)、王正民(山东冠县)、杨兰英(河北衡水)研究探讨,最终研制出了运用中药内服、外洗和药枕综合治疗白发的技术,并在书信诊所、正民诊所进行了5年多临床检验。
【发明内容】
针对现有技术的不足,本发明提供了一种内服、外洗和药枕联合使用综合治疗白发的药物和制备方法,从根源出发,能够补肝肾、益精血、润肠燥、健脾运、滋胃阴、润肺生津、清热凉血、通经活络、乌须发,治疗白发效果显著,且无毒副作用。
本发明治疗白发的药物包括1个中药内服方、辅以1个外洗方、1个药枕方,具体如下:
内服方(乌发I号方-五子乌首丸):由如下重量份的原料药制成,九蒸九晒黑芝麻10-50份、菟丝子2-40份、五味子2-40份、沙苑子2-40份、女贞子2-40份、墨旱莲2-40份,熟地黄3-50份、阿胶1-10份、人参1-10份、茯苓3-20份、甘草3-20份。
外洗方:由如下重量份的原料药制成,制首乌2-40份、土马鬃2-40份、侧柏叶2-40份、羌活2-40份。
药枕方(乌发I号药枕方):由如下重量份的原料药制成:荞麦壳100-3000份、当归20-80份、党参20-80份、黄芪20-80份、香附20-80份、川芎20-80份、冰片5-50份、甘草10-50份。
所述药物的重量份优选为:
内服方(乌发I号方-五子乌首丸):由如下重量份的原料药制成,九蒸九晒黑芝麻10-30份、菟丝子5-20份、五味子5-20份、沙苑子5-20份、女贞子5-20份、墨旱莲5-20份、熟地黄6-24份、阿胶4-6份、人参4-6份、茯苓6-10份、甘草6-10份。
外洗方:由如下重量份的原料药制成,制首乌5-20份、土马鬃5-20份、侧柏叶5-20份、羌活5-20份。
药枕方(乌发I号药枕方):由如下重量份的原料药制成:荞麦壳500-2500份、当归40-60份、党参30-50份、黄芪30-50份、香附30-50份、川芎30-50份、冰片10-30份、甘草20-40份。
所述药物的最佳重量份为:
内服方(乌发I号方-五子乌首丸):由如下重量份的原料药制成,九蒸九晒黑芝麻20份、菟丝子10份、五味子10份、沙苑子10份、女贞子10份、墨旱莲10份、熟地黄12份、阿胶5份、人参5份、茯苓8份、甘草8份。
外洗方:由如下重量份的原料药制成,制首乌10份、土马鬃10份、侧柏叶10份、羌活10份。
药枕方(乌发I号药枕方):由如下重量份的原料药制成:荞麦壳1500份、当归50份、党参40份、黄芪40份、香附40份、川芎40份、冰片20份、甘草30份。
上述药物的制备方法如下:
内服方(乌发I号方-五子乌首丸):按处方称取九蒸九晒黑芝麻、菟丝子、五味子、沙苑子、女贞子、墨旱莲,熟地黄、阿胶、人参、茯苓、甘草。将原料药粉碎成细粉,过筛,制成常规内服剂型。内服使用,一天3次,一次1丸,2个月为一疗程。内服方用药禁忌:一是患感冒咳嗽发烧、腹泻或其他病症时停药。二是戒烟酒和辛辣刺激之品。三是糖尿病、高血压和肾功能不全患者慎用。
所述剂型优选为丸剂,制备方法为将药物细粉和等量炼蜜制成蜜丸。
外洗方:按处方称取制首乌、土马鬃、侧柏叶、羌活,将上述药物研磨成粉末,直接熬水使用,或制成常规外洗剂型。外洗同时按摩头皮10分钟,吹干头发。
药枕方(乌发I号药枕方):按处方称取荞麦壳、当归、党参、黄芪、香附、川芎、冰片、甘草,将上述药物粉碎成粗粉,装入枕芯使用。
黑芝麻为脂麻科(胡麻科)脂麻属植物脂麻Sesamum indicum L.的干燥成熟种子。补肝肾,益精血,润肠燥。
菟丝子 为旋花科植物菟丝子Cuscuta chinensis Lam.的干燥成熟种子。滋补肝肾,固精缩尿,安胎,明目,止泻。
五味子 为木兰科植物五味子Schisandra chinensis(Turcz.)Baill.或华中五味子Schisandra sphenanthera Rehd.et Wils.的干燥成熟果实。收敛固涩,益气生津,补肾宁心。
沙苑子 为豆科植物扁茎黄芪Astragalus complanatus R.Brown.的干燥成熟种子。温补肝肾,固精,缩尿,明目。
女贞子 为木犀科植物女贞Ligustrum lucidum Ait.的干燥成熟果实。滋补肝肾,明目乌发。
墨旱莲 为菊科植物鳢肠Eclipta prostrata L.的干燥地上部分。滋补肝肾,凉血止血。
熟地黄 地黄为玄参科植物地黄Rehmannia glutinosa Libosch.的新鲜或干燥块根。熟地黄平补肝肾,养血滋阴。
阿胶 为马科动物驴Equus Asinus L.的皮经煎煮、浓缩制成的固体胶。补血滋阴,润燥,止血。
人参 为五加科植物人参Panax ginseng C.A.Mey.的干燥根。大补元气,复脉固脱,补脾益肺,生津,安神。
茯苓 为多孔菌科真菌茯苓Poria cocos(Schw.)Wolf的干燥菌核。利水渗湿,健脾宁心。
甘草 为豆科植物甘草Glycyrrhiza uralensis Fisch.、胀果甘草Glycyrrhizainflata Bat.或光果甘草Glycyrrhiza glabra L.的干燥根。补脾益气,清热解毒,祛痰止咳,缓急止痛,调和诸药。
制首乌 为蓼科植物何首乌Polygonum multiflorum Thunb.的干燥块根。制首乌补肝肾,益精血,乌须发,壮筋骨。
土马鬃 为金发藓科植物金发藓的植物体。滋阴清热;凉血止血。
侧柏叶 为柏科植物侧柏Platycladus orientalis(L.)Franco的干燥枝梢及叶。凉血止血,生发乌发。
羌活 为伞形科植物羌活(背翅芹)Notopterygium incisum Ting ex H.T.Chang或宽叶羌活Notopterygium forbesii Boiss.的干燥根茎及根。散寒,祛风,除湿,止痛。
荞麦壳 蓼科荞麦属植物荞麦Fagopyrum esculentum Moench.种子的皮壳。清脑,明目。
当归 为伞形科植物当归Angelica sinensis(Oliv.)Diels的干燥根。补血活血,调经止痛,润肠通便。
党参 为桔梗科植物党参Codonopsis pilosula(Franch.)Nannf.、素花党参(西党参)Codonopsis pilosula Nannf.var.modesta(Nannf.)L.T.Shen或川党参Codonopsistangshen Oliv.的干燥根。补中益气,健脾益肺。
黄芪 为豆科植物蒙古黄芪Astragalus membranaceus(Fisch.)Bge.var.mongholicus(Bge.)Hsiao或膜荚黄芪Astragalus membranaceus(Fisch.)Bge.的干燥根。补气固表,利尿托毒,排脓,敛疮生肌。
香附 为莎草科植物莎草Cyperus rotundus L.的干燥根茎。行气解郁,调经止痛。
川芎 为伞形科植物川芎Ligusticum chuanxiong Hort.(或Ligusticumwallichii Franch.)的干燥根茎。活血行气,祛风止痛。
冰片 为龙脑香科植物龙脑香树脂的加工品,或为樟脑、松节油等用化学方法合成的加工制成品。通诸窍,散郁火,去翳明目,消肿止痛。
中医认为,肾主藏精,其华在发;肝主藏血,发为血之余,精血不足,黑发不生。血气旺盛,则毛发也旺盛,血气虚亏,则毛发枯萎、脱落或变白。肺主皮毛,皮毛赖肺的精气以滋养和温煦,肺气虚衰则皮毛干枯不泽,白发早生。医学研究证明,精血双亏、肝肾受损,脏腑失调,是白发的主要根源。本发明内服方中黑芝麻又名巨胜子,与菟丝子、黑故子、覆盆子、女贞子“五子”均能乌须发,故名“五子乌发丸”。黑芝麻经九蒸九晒,可补肝肾、滋五脏、益精血、润肠燥、乌须发,为君药。菟丝子、五味子、沙苑子、女贞子均乌须发;墨旱莲合女贞子为“二至丸”,可强阴肾、乌髭发;熟地黄交通肝肾,滋阴补血、填精补髓;阿胶为血肉有情之品,既补肝血又补肾精,为臣药。人参和茯苓健脾运、滋胃阴,润肺生津,使诸药运而不生燥,补而偏滋腻,鼓舞清阳,振动中气为佐药。甘草调和诸药,为使药。外洗方中首乌养血祛风、乌发美髯,为君药。土马鬃滋阴清热,凉血止血;侧柏叶凉血乌发,为臣药。羌活散寒祛风、无孔不入,为引药。中医认为,“鼻孔为肺之窍,其气上通于脑,下行于肺”“鼻纳而通六经”,运用“闻药治病”理论,乌发I号药枕方采用当归、黄芪等气味俱厚之品,其中主药芯中荞麦壳能促进头部微循环,有效改善脑部供血供氧,活化头皮细胞;药芯中当归、黄芪、白芷、香附等药味,从鼻而入,上通于脑,下达于肺,通十二经脉,以益气养血、凉血活血、化湿健脾、疏肝理气、实现乌发目的。上述药物配合使用,共奏补肝肾、益精血、润肠燥、健脾运、滋胃阴、润肺生津、清热凉血、通经活络、疏肝理气、乌须发之功,达到全方位综合治疗、使白发转黑或防止白发增多的效果。本发明药物组合物是在中医药理论和近代医学研究的指导下得出的组合物配方,药物配方严谨、君臣佐使诸药相合,从根源出发,对症下药,疗效快、效果明显、且无毒副作用,对于治疗白发效果显著。
【具体实施方式】
下面的实施例可以帮助本领域的技术人员更全面的理解本发明,但不能以任何方式限制本发明。
实施例1:
称取九蒸九晒黑芝麻10克、菟丝子5克、五味子5克、沙苑子5克、女贞子5克、墨旱莲5克、熟地黄6克、阿胶4克、人参4克、茯苓6克、甘草6克,将上述药物粉碎为细粉,过筛,和等量炼蜜制成9克的蜜丸内服;
称取制首乌5克、土马鬃5克、侧柏叶5克、羌活5克,将上述药物研磨成粉末,熬水;
称取荞麦壳500克、当归40克、党参30克、黄芪30克、香附30克、川芎30克、冰片10克、甘草20克,将上述药物打成粗粉,装入枕芯使用。
使用方法:内服方一天3次,一次1丸,2个月为一疗程,同时辅以外洗方每天熬水温洗,并按摩头皮10分钟吹干头发,以及睡眠时使用药枕。
用药禁忌:一是患感冒咳嗽发烧、腹泻或其他病症时停药。二是戒烟酒和辛辣刺激之品。三是糖尿病、高血压和肾功能不全患者慎用。
实施例2
称取九蒸九晒黑芝麻30克、菟丝子20克、五味子20克、沙苑子20克、女贞子20克、墨旱莲20克、熟地黄24克、阿胶6克、人参6克、茯苓10克、甘草10克,将上述药物粉碎为细粉,过筛,和等量炼蜜制成9克的蜜丸内服;
称取制首乌20克、土马鬃20克、侧柏叶20克、羌活20克,将上述药物研磨成粉末,熬水;
称取荞麦壳2500克、当归60克、党参50克、黄芪50克、香附50克、川芎50克、冰片30克、甘草40克,将上述药物打成粗粉,装入枕芯使用。
内服方一天3次,一次1丸,2个月为一疗程,同时辅以外洗方每天熬水温洗,并按摩头皮10分钟吹干头发,以及睡眠时使用药枕。
用药禁忌:一是患感冒咳嗽发烧、腹泻或其他病症时停药。二是戒烟酒和辛辣刺激之品。三是糖尿病、高血压和肾功能不全患者慎用。
实施例3
称取九蒸九晒黑芝麻20克、菟丝子10克、五味子10克、沙苑子10克、女贞子10克、墨旱莲10克、熟地黄12克、阿胶5克、人参5克、茯苓8克、甘草8克,将上述药物粉碎为细粉,过筛,和等量炼蜜制成9克的蜜丸内服;
称取制首乌10克、土马鬃10克、侧柏叶10克、羌活10克,将上述药物研磨成粉末,熬水;
称取荞麦壳1500克、当归50克、党参40克、黄芪40克、香附40克、川芎40克、冰片20克、甘草30克,将上述药物打成粗粉,装入枕芯使用。
内服方一天3次,一次1丸,2个月为一疗程,同时辅以外洗方每天熬水温洗,并按摩头皮10分钟吹干头发,以及睡眠时使用药枕。
用药禁忌:一是患感冒咳嗽发烧、腹泻或其他病症时停药。二是戒烟酒和辛辣刺激之品。三是糖尿病、高血压和肾功能不全患者慎用。
【疗效评价】
1、一般资料:2013年至2018年间的5年多时间内,于书信诊所、正民诊所治疗的白发患者450例,患白发的原因为气血不足、肝肾亏虚等,患者职业包括公务员、城镇职工、农民、学生、老师等,其中女性182名、男性118名,年龄最小15岁,最大44岁,平均年龄23岁。
2、诊断标准:
I度白发:头发中白发的数量在10根以下;
II度白发:头发中白发的数量在10-100根之间;
III度白发:头发中白发的数量多于101根。
3、治疗方法:
在患者自愿的情况下,随机分为三组进行治疗,每组150名,两组患者在平均年龄、病程、病情无显著差异。
第一组患者使用实施例3中制备的口服方,一天3次,一次1丸,同时辅以外洗方每天熬水温洗,并按摩头皮10分钟吹干头发,睡眠时使用药枕,2个月为一疗程,治疗三个疗程。
第二组患者仅使用实施例3中制备的口服方,一天3次,一次1丸,2个月为一疗程,治疗三个疗程。
第三组患者使用九蒸九晒黑芝麻20克、菟丝子10克、五味子10克、沙苑子10克、女贞子10克、墨旱莲10克、熟地黄12克、阿胶5克、人参5克、茯苓8克、甘草8克、制首乌5克、土马鬃5克、侧柏叶5克、羌活5克、当归5克、党参4克、黄芪4克、香附4克、川芎4克、冰片2克将上述药物粉碎为细粉,过筛,和炼蜜制成12克的蜜丸内服,一天3次,一次1丸,2个月为一疗程,治疗三个疗程。
4、疗效判定:治疗结束后头发中白发数量10根以下为治愈、30-50根以下为显效、50根以上为无效。
治愈 | 显效 | 无效 | 有效率 | |
第一组 | 126 | 9 | 15 | 90% |
第二组 | 31 | 63 | 56 | 62.7% |
第三组 | 49 | 51 | 50 | 66.7% |
由以上结果可以看出,第一组采用本发明的口服方辅以外洗方和药枕进行治疗,治疗效果远好于仅使用口服方进行治疗的第二组;第三组采用口服方适量加入外洗方和药枕中的原料药一同制成的口服药物仅进行口服给药治疗,虽然该组口服药物中原料药种类增多,治疗效果好于仅使用口服方进行治疗的第二组,但疗效远不如第一组综合治疗的好。足见本发明的药物配方严谨、君臣佐使诸药相合,药物方法和综合的治疗方法相结合,协同生效,能够取得显著的治疗效果。
典型病例一:姚某某,女,35岁,山东聊城人,2017年6月3日初诊。近年来,身体倦怠乏力,白发越来越多,头顶部白发更多,睡眠不好,月经错后而量少,脸色发黄,舌淡、苔白,脉沉细。四诊合参为气血不足、肝肾不足所致,投实施例2所制乌发I号方(五子乌首丸)180丸,一天三次,一次一丸,两月一疗程,同时辅以外洗方和乌发I号药枕增强疗效,医嘱每天坚持梳头15分钟,促进头部血液循环。2017年8月3日二诊。脸色明显红润,身体有力,发现新生黑发10余根,患者增强了治疗白发的信心。再投乌发I号方(五子乌首丸)180丸,其他不变。2017年10月11日三诊。白发基本全部变黑,医嘱每天坚持梳头15分钟,促进头部血液循环。一年后电话随访,白发没有增多。
典型病例二:杨女士,44岁,公务员。2018年1月12日初诊。自诉近两年因工作忙压力大,从早上到晚敲键盘,白发逐渐增多,睡眠不好,脸色发暗,经常腰膝酸软,白发主要集中在两鬓和头顶,舌淡白,脉沉细。此病例属于正常衰老造成白发,加上工作长时间使用电脑,久视伤血,治疗难度相对较大。四诊合参为气血不足、肝肾不足所致,投实施例1所制乌发I号方(五子乌首丸)180丸,一天三次,一次一丸,两月一疗程,辅以外洗方和乌发I号药枕增强疗效,医嘱每天坚持梳头15分钟,少看电脑手机,多晒太阳多运动。2018年3月15日二诊。精神状态好转,腰膝酸软减轻,检查头发有些白发根部变黑。再投乌发I号方(五子乌首丸)180丸,其他不变。2018年5月8日三诊。白发变黑明显,医嘱不变,再服乌发I号方(五子乌首丸)两个疗程。一年后电话随访,仍有十几根白发,但没有增多,对治疗效果十分满意。
本领域的普通技术人员可以理解:在不脱离本发明的原理和宗旨下可以对这些实施例进行多种变化、修改、替换和变型,本发明的范围由权利要求及其等同物限定。
Claims (8)
1.一种治疗白发的药物,其特征在于:内服方由如下重量份的原料药制成,九蒸九晒黑芝麻10-50份、菟丝子2-40份、五味子2-40份、沙苑子2-40份、女贞子2-40份、墨旱莲2-40份,熟地黄3-50份、阿胶1-10份、人参1-10份、茯苓3-20份、甘草3-20份。
2.根据权利要求1所述的治疗白发的药物,其特征在于:所述内服方与外洗方和药枕方联合使用,内服方由如下重量份的原料药制成,九蒸九晒黑芝麻10-50份、菟丝子2-40份、五味子2-40份、沙苑子2-40份、女贞子2-40份、墨旱莲2-40份,熟地黄3-50份、阿胶1-10份、人参1-10份、茯苓3-20份、甘草3-20份;外洗方由如下重量份的原料药制成,制首乌2-40份、土马鬃2-40份、侧柏叶2-40份、羌活2-40份;药枕方由如下重量份的原料药制成:荞麦壳100-3000份、当归20-80份、党参20-80份、黄芪20-80份、香附20-80份、川芎20-80份、冰片5-50份、甘草10-50份。
3.根据权利要求2所述的治疗白发的药物,其特征在于内服方由如下重量份的原料药制成,九蒸九晒黑芝麻10-30份、菟丝子5-20份、五味子5-20份、沙苑子5-20份、女贞子5-20份、墨旱莲5-20份、熟地黄6-24份、阿胶4-6份、人参4-6份、茯苓6-10份、甘草6-10份;外洗方由如下重量份的原料药制成,制首乌5-20份、土马鬃5-20份、侧柏叶5-20份、羌活5-20份;药枕方由如下重量份的原料药制成:荞麦壳500-2500份、当归40-60份、党参30-50份、黄芪30-50份、香附30-50份、川芎30-50份、冰片10-30份、甘草20-40份。
4.根据权利要求2所述的治疗白发的药物,其特征在于内服方由如下重量份的原料药制成,九蒸九晒黑芝麻20份、菟丝子10份、五味子10份、沙苑子10份、女贞子10份、墨旱莲10份、熟地黄12份、阿胶5份、人参5份、茯苓8份、甘草8份;外洗方由如下重量份的原料药制成,制首乌10份、土马鬃10份、侧柏叶10份、羌活10份;药枕方由如下重量份的原料药制成:荞麦壳1500份、当归50份、党参40份、黄芪40份、香附40份、川芎40份、冰片20份、甘草30份。
5.根据权利要求1-4任一项所述的治疗白发的药物的内服方的制备方法,其特征在于:按处方称取九蒸九晒黑芝麻、菟丝子、五味子、沙苑子、女贞子、墨旱莲,熟地黄、阿胶、人参、茯苓、甘草,将原料药粉碎成细粉,过筛,制成常规内服剂型。
6.根据权利要求2-4任一项所述的治疗白发的药物的外洗方的制备方法,其特征在于:按处方称取制首乌、土马鬃、侧柏叶、羌活,将上述药物研磨成粉末,直接熬水使用,或制成常规外洗剂型。
7.根据权利要求2-4任一项所述的治疗白发的药物的药枕方的制备方法,其特征在于:按处方称取荞麦壳、当归、党参、黄芪、香附、川芎、冰片、甘草,将上述药物粉碎成粗粉,装入枕芯使用。
8.根据权利要求5所述的治疗发白的药物的内服方的制备方法,其特征在于将药物细粉和等量炼蜜制成蜜丸。
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