CN112472652A

CN112472652A - Ointment containing traditional Chinese medicine components and application thereof

Info

Publication number: CN112472652A
Application number: CN202011493021.3A
Authority: CN
Inventors: 刘海兰
Original assignee: Hubei Ancient Prescription Zhishengtang Facial Cleaning Service Co ltd
Current assignee: Hubei Ancient Prescription Zhishengtang Facial Cleaning Service Co ltd
Priority date: 2020-12-16
Filing date: 2020-12-16
Publication date: 2021-03-12
Anticipated expiration: 2040-12-16
Also published as: CN112472652B

Abstract

The invention relates to the technical field of cosmetics, in particular to an ointment containing traditional Chinese medicine components and application thereof. 40-45 parts of deionized water, 3-8 parts of humectant, 1-5 parts of astringent, 0.3-1 part of emollient, 16-23 parts of calcium hydroxide, 16-22 parts of sodium carbonate, 10-15 parts of adsorbent, 0.2-1 part of repairing agent and 0.01-0.1 part of antioxidant. The ointment containing the traditional Chinese medicine components prepared by the invention not only has the effects of moistening skin and moisture, but also has the effects of effectively softening pathological tissues, diminishing inflammation, detoxifying and blocking blood vessels by extracting active substances in the traditional Chinese medicine components, so that the broad-spectrum nevus and wart removing effects are achieved, and the prepared ointment is fresh and comfortable in use, high in sensory evaluation and free of allergy and irritation use defects.

Description

Ointment containing traditional Chinese medicine components and application thereof

Technical Field

The invention relates to the technical field of cosmetics, in particular to an ointment containing traditional Chinese medicine components and application thereof.

Background

The skin is used as the first physiological defense line and the largest organ of the human body, maintains the opposition and unification of the body and the natural environment, constantly participates in the functional activity of the body, and the abnormal condition of the body can be reflected on the surface of the skin. The skin has a plurality of physiological protection functions: such as barrier function, sensory function, body temperature regulation, absorption function, secretion and excretion function, etc., and plays an important role in maintaining the health of the body. Skin diseases can be caused when the physiological functions of the skin are impaired.

Nevi are the most common benign skin tumors in humans, and are skin manifestations caused by epidermal and intradermal melanocyte proliferation. Nevi include various congenital and acquired melanocyte nevi, sebaceous gland nevi, etc. The term "nevus" is used in a narrow sense, and is also called nevus cell nevus, pigmented nevus, melanocytic nevus or normally acquired melanocytic nevus, excluding congenital melanocytic nevus. Depending on the location of mole cells in the skin, it can be divided into boundary mole, mixed mole and intradermal mole. Flat lesions indicate a boundary mole, slightly higher lesions are mostly mixed moles, and papillomatosis-like lesions and almost all hemispherical and pedicel lesions are intradermal moles. Moles with atypical appearance can become malignant, such as very dark moles, uneven pigmentation, uneven or irregular edges, indistinct boundaries, asymmetry from side to side, statistically greater than 5 mm in diameter. Nevi that grow in the nail sulcus, nails, extremities, oral mucosa, conjunctiva, vagina, and foreskin have a greater chance of becoming malignant melanoma than nevi elsewhere.

Warts are a skin surface neoplasm caused by human papilloma virus. The virus exists in acanthocyte, and can promote cell proliferation to form verrucous lesion. According to clinical manifestations and sites, the warts are classified into verruca vulgaris, verruca plana, verruca plantaris, genital warts (condyloma acuminatum), oral warts, laryngeal warts, and epidermodysplasia verruciformis. Warts are caused by human papillomavirus infection. Can be transmitted by direct or indirect contact, and perianal and genital warts are mostly transmitted by sexual contact. Trauma or skin breakdown are important factors for HPV infection. The course of warts is important in the immunity of the body, and the incidence of warts is increased in patients with immunodeficiency, such as kidney transplantation, malignant lymphoma, chronic lymphocytic leukemia and lupus erythematosus. The mechanism by which warts persist in relatively healthy people for a long time is currently unknown.

With the improvement of health consciousness and living standard, people pay special attention to the treatment of skin defects such as nevus, warts and the like. Based on the preparation, the preparation which is safe and stable, can effectively remove nevus and wart, is mild and has no stimulation to skin is the problem to be solved in the field.

Disclosure of Invention

The invention solves the technical problem which can be solved by the exclusive rights in the prior art by providing the name of the invention, and realizes the technical effect.

The invention provides an ointment containing traditional Chinese medicine components in a first aspect, which comprises the following raw materials: 40-45 parts of deionized water, 3-8 parts of humectant, 1-5 parts of astringent, 0.3-1 part of emollient, 16-23 parts of calcium hydroxide, 16-22 parts of sodium carbonate, 10-15 parts of adsorbent, 0.2-1 part of repairing agent and 0.01-0.1 part of antioxidant.

In a preferred embodiment, the raw materials of the ointment also comprise 5-12 parts of traditional Chinese medicine components.

In a preferred embodiment, the Chinese medicinal components include at least one of pueraria root, coix seed, scutellaria root, glycyrrhiza, broussonetia papyrifera and apocynum venetum.

In a preferred embodiment, the humectant comprises at least one of lactose, trehalose, propylene glycol, glycerol, chitin derivatives, sorbitol.

In a preferred embodiment, the astringent includes at least one of lactic acid, salicylic acid, zinc p-hydroxybenzenesulfonate.

In a preferred embodiment, the emollient comprises at least one of polydimethylsiloxane, polymethylphenylsiloxane, and cyclic polysiloxane.

In a preferred embodiment, the adsorbent comprises at least one of zinc stearate, polyethylene powder, cellulose microbeads, and magnesium hydroxide.

In a preferred embodiment, the repairing agent comprises at least one of talc powder, calcium carbonate, wollastonite, pearl powder, mica powder, kaolin and silicon-aluminum powder.

In a preferred embodiment, the antioxidant comprises at least one of tert-butyl hydroxyanisole, tocopherol acetate, ascorbic acid, di-tert-butyl p-cresol, and tea polyphenols.

In a second aspect, the present invention provides an application of an ointment containing traditional Chinese medicine components, wherein the ointment is particularly suitable for treating black nevus, meat nevus, subcutaneous nevus, blue nevus, freckles, subcutaneous plaques, age spots, pigmented spots, sweat spots, syringoma, whelk, acne, ichthyosis vulgaris, verruca plana, verruca filiformis, verruca vulgaris and blackheads. Has the advantages that:

the ointment containing the traditional Chinese medicine components prepared by the invention not only has the effects of moistening skin and moisture, but also has the effects of effectively softening pathological tissues, diminishing inflammation, detoxifying and blocking blood vessels by extracting active substances in the traditional Chinese medicine components, so that the broad-spectrum nevus and wart removing effects are achieved, and the prepared ointment is fresh and comfortable in use, high in sensory evaluation and free of allergy and irritation use defects.

Detailed Description

The disclosure may be understood more readily by reference to the following detailed description of preferred embodiments of the invention and the examples included therein. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In case of conflict, the present specification, including definitions, will control.

The term "prepared from …" as used herein is synonymous with "comprising". The terms "comprises," "comprising," "includes," "including," "has," "having," "contains," "containing," or any other variation thereof, as used herein, are intended to cover a non-exclusive inclusion. For example, a composition, process, method, article, or apparatus that comprises a list of elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, process, method, article, or apparatus.

The conjunction "consisting of …" excludes any unspecified elements, steps or components. If used in a claim, the phrase is intended to claim as closed, meaning that it does not contain materials other than those described, except for the conventional impurities associated therewith. When the phrase "consisting of …" appears in a clause of the subject matter of the claims rather than immediately after the subject matter, it defines only the elements described in the clause; other elements are not excluded from the claims as a whole.

When an amount, concentration, or other value or parameter is expressed as a range, preferred range, or as a range of upper preferable values and lower preferable values, this is to be understood as specifically disclosing all ranges formed from any pair of any upper range limit or preferred value and any lower range limit or preferred value, regardless of whether ranges are separately disclosed. For example, when a range of "1 to 5" is disclosed, the described range should be interpreted to include the ranges "1 to 4", "1 to 3", "1 to 2 and 4 to 5", "1 to 3 and 5", and the like. When a range of values is described herein, unless otherwise stated, the range is intended to include the endpoints thereof and all integers and fractions within the range.

The singular forms "a", "an" and "the" include plural referents unless the context clearly dictates otherwise. "optional" or "any" means that the subsequently described event or events may or may not occur, and that the description includes instances where the event occurs and instances where it does not.

Approximating language, as used herein throughout the specification and claims, is intended to modify a quantity, such that the invention is not limited to the specific quantity, but includes portions that are literally received for modification without substantial change in the basic function to which the invention is related. Accordingly, the use of "about" to modify a numerical value means that the invention is not limited to the precise value. In some instances, the approximating language may correspond to the precision of an instrument for measuring the value. In the present description and claims, range limitations may be combined and/or interchanged, including all sub-ranges contained therein if not otherwise stated.

In addition, the indefinite articles "a" and "an" preceding an element or component of the invention are not intended to limit the number requirement (i.e., the number of occurrences) of the element or component. Thus, "a" or "an" should be read to include one or at least one, and the singular form of an element or component also includes the plural unless the stated number clearly indicates that the singular form is intended.

"Polymer" means a polymeric compound prepared by polymerizing monomers of the same or different types. The generic term "polymer" embraces the terms "homopolymer", "copolymer", "terpolymer" and "interpolymer". "interpolymer" means a polymer prepared by polymerizing at least two different monomers. The generic term "interpolymer" includes the term "copolymer" (which is generally used to refer to polymers prepared from two different monomers) and the term "terpolymer" (which is generally used to refer to polymers prepared from three different monomers). It also includes polymers made by polymerizing more monomers. "blend" means a polymer formed by two or more polymers being mixed together by physical or chemical means.

In order to solve the above problems, the present invention provides an ointment containing Chinese medicinal components, which comprises the following raw materials: 40-45 parts of deionized water, 3-8 parts of humectant, 1-5 parts of astringent, 0.3-1 part of emollient, 16-23 parts of calcium hydroxide, 16-22 parts of sodium carbonate, 10-15 parts of adsorbent, 0.2-1 part of repairing agent and 0.01-0.1 part of antioxidant.

In some preferred embodiments, the raw materials of the ointment further comprise 5-12 parts of traditional Chinese medicine components.

In some preferred embodiments, the Chinese medicinal components include at least one of pueraria lobata, coix seed, scutellaria baicalensis, glycyrrhiza uralensis, papermulberry fruit and apocynum venetum.

Further preferably, the traditional Chinese medicine components are kudzu root, scutellaria, liquorice and apocynum.

The latin name of kudzu Root is Lobed Kudzuvine Root, the latin name of baikal skullcap Root is Scutellaria basilica Georgi, the latin name of licorice Root is Glycyrrhiza uralensis Fisch, the latin name of bluish dogbane is A.vetetum L.

The kudzuvine root is purchased from Guangzhou cabbage source agricultural science and technology company Limited; scutellaria was purchased from hong bao tang commerce and trade limited of the zhou city; liquorice is purchased from the pharmaceutical industry limited company of hundred million hong Tang, Bozhou city; apocynum venetum is purchased from Hengyi Chinese medicine science and technology Limited company in the city of Bozhou.

The applicant finds that the wart and nevus removing effect of the ointment can be improved after the traditional Chinese medicine components are added into the ointment, and the improvement effect is most obvious when the traditional Chinese medicine components are selected from kudzu root, scutellaria baicalensis, liquorice and dogbane leaf to act together. The reason may be that the kudzu root, the baical skullcap root, the liquoric root and the apocynum venetum leaf contain active ingredients for inhibiting the generation of melanin, and the effects of preventing the synthesis of tyrosinase protein, further reducing the content of melanin in cells and repairing the skin can be achieved by reducing the activity of tyrosinase for synthesizing the melanin in the skin layer.

However, the applicant also found that when the powder of the traditional Chinese medicine components is directly added into the ointment, the traditional Chinese medicine components need to be added in a large amount to exert the skin care effect, but the large amount of the traditional Chinese medicine components cause the negative effect that the calcium hydroxide, the emollient, the humectant and other components in the system are not well mixed, the storage stability of the ointment is limited, and the phenomenon of layering of the ointment occurs when the ointment is stored for a short time at the temperature of more than 40 ℃. When the traditional Chinese medicine components are extracted by a specific method and then added into the ointment, the compatibility of the traditional Chinese medicine components with substances such as a humectant, an astringent and the like is obviously improved, and the storage stability of the ointment is improved.

In some preferred embodiments, the preparation of the herbal ingredients comprises:

s1, cleaning the traditional Chinese medicine raw materials, drying, crushing, and sieving by a 40-80-mesh sieve to obtain solid powder.

S2, adding the solid powder obtained in the step 1 into an ethanol water solution (the volume ratio of ethanol to water is 3: 1), wherein the weight ratio of the solid powder to the ethanol water solution is 1: (20-40); heating and stirring in a constant temperature water bath oscillator for extraction at 35-50 deg.C for 30-70 min; heating for extraction, filtering, and collecting filtrate.

S3, desolventizing and concentrating the filtrate obtained in the step S2 on a rotary evaporator for 20-40min, carrying out vacuum freeze drying on the concentrated solution, grinding the dried product, and sieving the product through a 60-100-mesh sieve to obtain the required traditional Chinese medicine components.

More preferably, the weight ratio of the kudzu root, the baical skullcap root, the liquoric root and the apocynum venetum is (0.5-2): (1-3.2): (3-6): 1.

the applicant unexpectedly finds that when the weight ratio of the kudzu root to the baical skullcap root to the liquoric root to the apocynum venetum is (0.5-2): (1-3.2): (3-6): 1, the prepared ointment has better sensory experience when being applied to the skin, the product has fresh and fine texture and is easy to push away, and the skin does not have irritant feeling. Possibly the weight ratio is (0.5-2): (1-3.2): (3-6): 1, the kudzu vine root, the scutellaria baicalensis, the liquorice and the apocynum venetum extract can be combined with an adsorbent, an astringent and other substances to the maximum extent, so that the capability of the ointment penetrating into the skin is enhanced, the ointment can be uniformly attached to the surface of the skin to form a protective barrier, and the use sensory experience of the product is improved.

Humectant:

the moisturizer is a functional cosmetic raw material which can keep or increase the moisture of the upper layer of the skin under wider humidity fluctuation, and can delay the loss of the moisture and promote the moisture permeation of dermis-epidermis by forming a layer of film on the surface of the skin, thereby providing moisturizing protection for the skin, reducing the damage of the skin caused by the loss of the moisture and promoting the skin repair process. The traditional moisturizer can only achieve the effect of sealing and moisturizing, and along with the development of scientific technology and consumer demands, the moisturizer can achieve stronger skin care effect by being compatible with other cosmetic raw materials while maintaining the skin hydration.

In some preferred embodiments, the humectant comprises at least one of lactose, trehalose, propylene glycol, glycerol, chitin derivatives, sorbitol.

Further preferably, the humectant comprises lactose and trehalose.

Lactose is available under CAS number 63-42-3, and is commercially available, for example, from Shandongtai Biotech, Inc.

Trehalose is available under CAS number 99-20-7, and is commercially available, for example, from Shanghai Michelin Biotech, Inc.

More preferably, the weight ratio of lactose to trehalose is (1-5): 1.

astringents:

the astringent is a material capable of shrinking tissues or coagulating cell surface proteins to reduce secretion, and when applied to the skin or mucosa, it can promote local protein coagulation to protect the skin or mucosa. The traditional astringents are mainly inorganic powder such as zinc oxide, aluminum chloride and the like, and practice proves that the astringent causes skin burden, worsens skin quality and disturbs the defense mechanism of skin after long-term use. The organic acid astringent has fewer side effects and can achieve the effect of astringing the skin in a short time, so that the organic acid astringent is increasingly applied to skin care products.

In some preferred embodiments, the astringent includes at least one of lactic acid, salicylic acid, zinc p-hydroxybenzenesulfonate.

More preferably, the astringent is lactic acid with CAS number 50-21-5.

Lactic acid may be commercially available, for example from sincere biotechnology limited of denying.

And (3) an emollient:

emollients are a class of cosmetic ingredients that have good spreadability, improve the appearance of the skin, and make the skin smooth, pliable, and shiny. Polysiloxane is also called silicone or silicone oil, and it and its derivative are high-quality raw materials with high stability, softness and lubricity in cosmetics. The polysiloxane has good skin penetration effect, low consistency, strong dispersibility, and no irritation burden on skin and mucosa.

In some preferred embodiments, the emollient comprises at least one of polydimethylsiloxane, polymethylphenylsiloxane, and cyclic polysiloxane.

Further preferably, the emollient is a cyclic polysiloxane.

Still more preferably, the emollient is cyclomethicone, which can be commercially available, for example, Anhui Jordan Silicone oil, Inc.

In some preferred embodiments, the weight ratio of calcium hydroxide to sodium carbonate is (1.2-1.4): 1.

in some preferred embodiments, the adsorbent comprises at least one of zinc stearate, polyethylene powder, cellulose microbeads, magnesium hydroxide.

Further preferably, the adsorbent comprises cellulose microbeads and/or magnesium hydroxide.

In some preferred embodiments, the repair agent comprises at least one of talc, calcium carbonate, wollastonite, pearl powder, mica powder, kaolin, and silica-alumina powder.

Further preferably, the repairing agent is pearl powder and mica powder, and the particle size of the pearl powder and the mica powder is 200-1000 meshes. The pearl powder with the particle size of 200-; the mica powder with the particle size of 200-.

More preferably, the weight ratio of the pearl powder to the mica powder is 1: (8-17).

Antioxidant:

antioxidants are substances that help to trap and neutralize free radicals, thereby weakening the adverse effects of free radicals on the human body, and have a regulatory function on the human body. The antioxidant plays a role in preventing the oxidizable substances in cells from being oxidized, protecting the structural integrity of the cells, keeping the normal functions of organs and delaying the aging of human bodies in the metabolism process of the human bodies. The addition of antioxidant in cosmetic can also reduce the formation of superficial fine lines and wrinkles, improve excessive pigment accumulation, and enhance the crosslinking effect of active protein in skin. On the other hand, antioxidants can also inhibit the deterioration, discoloration and rancidity caused by the oxidation of unsaturated components in cosmetics.

In some preferred embodiments, the antioxidant comprises at least one of t-butyl hydroxyanisole, tocopherol acetate, ascorbic acid, di-t-butyl-p-cresol, tea polyphenols.

Further preferably, the antioxidant comprises tocopherol acetate and/or ascorbic acid.

The invention discovers that the ointment containing the traditional Chinese medicine components prepared by the raw materials can effectively improve the defects of nevus, wart and the like of the skin, and the reason is that active substances in the specific traditional Chinese medicine extracted components can effectively soften the affected part, further diminish inflammation, remove toxicity, destroy the growth environment of the variant cells, act on the root of a lesion and achieve the effect of eliminating the lesion cells; meanwhile, the repairing components in the ointment penetrate into the skin to protect and promote the formation of new skin tissues. The ointment containing the traditional Chinese medicine components is easy to use, can effectively improve the skin, is high in safety and stability, mild and non-irritant to the skin, and is suitable for various skin types.

In some preferred embodiments, the ointment containing the herbal ingredients is prepared by the steps of:

s1, adding a humectant, an emollient, calcium hydroxide, sodium carbonate and deionized water into a reaction vessel according to the formula amount, and stirring for 20-60min to obtain a mixture I;

s2, adding the traditional Chinese medicine components, the astringent, the adsorbent and the antioxidant into the first mixture according to the formula amount, heating to 30-40 ℃, stirring for 40-70min, then adding the repairing agent, and stirring for 40-70min to obtain a second mixture;

s3, putting the mixture into a high-speed shearing emulsifying machine, shearing and homogenizing for 20-30min under the condition that the rotating speed is 3000 plus 6000r/min to obtain a homogeneous liquid, detecting to be qualified, and subpackaging to obtain the ointment finished product.

In a second aspect, the present invention provides an application of an ointment containing traditional Chinese medicine components, wherein the ointment is particularly suitable for treating black nevus, meat nevus, subcutaneous nevus, blue nevus, freckles, subcutaneous plaques, age spots, pigmented spots, sweat spots, syringoma, whelk, acne, ichthyosis vulgaris, verruca plana, verruca filiformis, verruca vulgaris and blackheads.

In some preferred embodiments, the ointment is applied by:

cleaning skin, applying appropriate amount of ointment containing Chinese medicinal components to affected part with cleaning device, lightly touching and massaging the affected part with smooth rod-shaped device, adjusting application times and time according to the actual conditions (such as pigment depth and area) of the affected part until the effective components of the ointment penetrate into the affected part to completely remove the defect, and recovering the skin to be intact

When the ointment containing the traditional Chinese medicine components prepared by the invention is used, attention should be paid to the following components:

1) the affected part is prohibited from contacting water and also prohibited from contacting the irritant skin care product within 3 hours of using the product;

2) the product can be used for scrubbing by edible light salt water after 3 days;

3) the sharp and strong irritant food and the food with high melanin content are eaten as little as possible in the diet process;

4) naturally pulling the scab, and strictly forbidding using external force to make the scab fall off; the decrustation is influenced by the age of the patient, the condition of the skin, etc., and is usually 6-14 days. Practice proves that the longer the decrustation time is, the better the recovery condition of the skin tissue is, and the stronger the consistency of the newly grown skin tissue and the nearby skin part is.

Action process of the ointment:

1) after the ointment is applied to a patient, the affected part feels slightly red and swollen by 1-2cm, and the periphery of the affected part slightly turns white and black.

2) The patient can observe that the affected part is dry 24 hours after using the ointment, and a dark block (namely scab) appears, and the time for starting falling off of the block is about 4-7 days after using.

3) After the block falls off, the newly grown pale pink or black red delicate skin is exposed, and the specific recovery condition is related to the physique of the patient.

4) The skin tissue newly generated at the affected part with lighter pigment is relatively tender; the newly generated skin tissue of the affected part with deeper pigment is darker, the dark red damaged skin can still be seen after the block falls off, after 2 weeks, the newly generated skin tissue begins to generate pigmentation, the pigmentation is most obvious after 1 month (namely, the blackening period), the pigmentation begins to fade gradually, and the more 3-6 months is needed for complete fading; if the skin pigment still has obvious pigment residue after complete degerming, the product is applied again after the scab print is completely recovered.

5) The phenomenon that the part with deeper pigment at the junction is coated for 3-5 times is normal.

Examples

Example 1.

The embodiment provides an ointment containing traditional Chinese medicine components, which comprises the following raw materials: according to the weight parts, 41 parts of deionized water, 8 parts of traditional Chinese medicine components, 5 parts of humectant, 2.5 parts of astringent, 0.6 part of emollient, 20.5 parts of calcium hydroxide, 19.5 parts of sodium carbonate, 12.5 parts of adsorbent, 0.54 part of repairing agent and 0.04 part of antioxidant.

The traditional Chinese medicine components are kudzu root, scutellaria baicalensis, liquorice and apocynum venetum, and the weight ratio of the kudzu root to the scutellaria baicalensis to the liquorice to the apocynum venetum is 1: 2.4: 4: 1. the latin name of kudzu Root is Lobed Kudzuvine Root, the latin name of baikal skullcap Root is Scutellaria basilica Georgi, the latin name of licorice Root is Glycyrrhiza uralensis Fisch, the latin name of bluish dogbane is A.vetetum L.

The humectant is lactose and trehalose, and the weight ratio of the lactose to the trehalose is 2: 1.

the CAS number for lactose is 63-42-3, and is available from Shandong Fengtai Biotech Co.

Trehalose has a CAS number of 99-20-7 and is available from Shanghai Michelin Biotech, Inc.

The astringent is lactic acid, the CAS number is 50-21-5, and the astringent is purchased from Jincheng Chengning Biotechnology Limited in Jinan.

The emollient is cyclomethicone, available from Anhui Aiyuta Silicone oil, Inc.

The adsorbent is magnesium hydroxide, has a particle size of 1250 meshes and is purchased from Jinan Polychemotherapeutics, Inc.

The repairing agent comprises pearl powder and mica powder, wherein the weight ratio of the pearl powder to the mica powder is 1: 10. the pearl powder has a particle size of 800 meshes and is purchased from Spanish Biotechnology Co., Ltd; the particle size of the mica powder is 600 meshes and is purchased from a processing plant of Jiayuan mineral products in Lingshou county.

The antioxidant was tocopheryl acetate, CAS number 7695-91-2, purchased from Sigma-Aldrich, Inc. (Shanghai).

The Chinese medicinal components

The preparation method of the traditional Chinese medicine components comprises the following steps:

s1, cleaning the traditional Chinese medicine raw materials, drying, crushing, and sieving by a 60-mesh sieve to obtain solid powder.

S2, adding the solid powder obtained in the step 1 into an ethanol water solution (the volume ratio of ethanol to water is 3: 1), wherein the weight ratio of the solid powder to the ethanol water solution is 1: 30, of a nitrogen-containing gas; heating and stirring in a constant temperature water bath oscillator for extraction at 45 deg.C for 60 min; heating for extraction, filtering, and collecting filtrate.

S3, carrying out desolventizing concentration on the filtrate obtained in the step S2 on a rotary evaporator for 35min, carrying out vacuum freeze drying on the concentrated solution, grinding the dried product, and sieving the product with a 80-mesh sieve to obtain the required traditional Chinese medicine component.

The preparation method of the ointment containing the traditional Chinese medicine components comprises the following steps:

s1, adding a humectant, an emollient, calcium hydroxide, sodium carbonate and deionized water into a reaction vessel according to the formula amount, and stirring for 40min to obtain a mixture I;

s2, adding the traditional Chinese medicine components, the astringent, the adsorbent and the antioxidant into the first mixture according to the formula amount, heating to 36 ℃, stirring for 60min, then adding the repairing agent, and stirring for 55min to obtain a second mixture;

s3, putting the mixture II into a high-speed shearing emulsifying machine, shearing and homogenizing for 25min under the condition that the rotating speed is 5000r/min to obtain a homogeneous liquid, detecting to be qualified, and subpackaging to obtain a finished ointment.

Example 2.

The embodiment provides an ointment containing traditional Chinese medicine components, which comprises the following raw materials: the traditional Chinese medicine composition comprises, by weight, 40 parts of deionized water, 6 parts of a traditional Chinese medicine component, 4 parts of a humectant, 2 parts of an astringent, 0.5 part of an emollient, 17 parts of calcium hydroxide, 17 parts of sodium carbonate, 11 parts of an adsorbent, 0.2 part of a repairing agent and 0.01 part of an antioxidant.

The traditional Chinese medicine components are kudzu root, scutellaria baicalensis, liquorice and apocynum venetum, and the weight ratio of the kudzu root to the scutellaria baicalensis to the liquorice to the apocynum venetum is 1: 2.4: 4: 1. the kudzuvine root is purchased from Guangzhou cabbage source agricultural science and technology company Limited; scutellaria was purchased from hong bao tang commerce and trade limited of the zhou city; liquorice is purchased from the pharmaceutical industry limited company of hundred million hong Tang, Bozhou city; apocynum venetum is purchased from Hengyi Chinese medicine science and technology Limited company in the city of Bozhou.

The emollient is cyclomethicone, available from Anhui Aiyuta Silicone oil, Inc.

Example 3.

The embodiment provides an ointment containing traditional Chinese medicine components, which comprises the following raw materials: the traditional Chinese medicine composition comprises, by weight, 44 parts of deionized water, 12 parts of a traditional Chinese medicine component, 6 parts of a humectant, 4 parts of an astringent, 0.8 part of an emollient, 22 parts of calcium hydroxide, 21 parts of sodium carbonate, 14 parts of an adsorbent, 0.7 part of a repairing agent and 0.1 part of an antioxidant.

The emollient is cyclomethicone, available from Anhui Aiyuta Silicone oil, Inc.

Example 4.

The traditional Chinese medicine components are kudzu root, scutellaria baicalensis, liquorice and apocynum venetum, and the weight ratio of the kudzu root to the scutellaria baicalensis to the liquorice to the apocynum venetum is 1: 2: 3: 1. the kudzuvine root is purchased from Guangzhou cabbage source agricultural science and technology company Limited; scutellaria was purchased from hong bao tang commerce and trade limited of the zhou city; liquorice is purchased from the pharmaceutical industry limited company of hundred million hong Tang, Bozhou city; apocynum venetum is purchased from Hengyi Chinese medicine science and technology Limited company in the city of Bozhou.

The emollient is cyclomethicone, available from Anhui Aiyuta Silicone oil, Inc.

Example 5.

The humectant is lactose and trehalose, and the weight ratio of lactose to trehalose is 4: 1.

The emollient is cyclomethicone, available from Anhui Aiyuta Silicone oil, Inc.

Example 6.

The emollient is cyclomethicone, available from Anhui Aiyuta Silicone oil, Inc.

The repairing agent comprises pearl powder and mica powder, wherein the weight ratio of the pearl powder to the mica powder is 1: 16. the pearl powder has a particle size of 800 meshes and is purchased from Spanish Biotechnology Co., Ltd; the particle size of the mica powder is 600 meshes and is purchased from a processing plant of Jiayuan mineral products in Lingshou county.

Example 7.

The emollient is cyclomethicone, available from Anhui Aiyuta Silicone oil, Inc.

S2, adding the solid powder obtained in the step 1 into an ethanol water solution (the volume ratio of ethanol to water is 3: 1), wherein the weight ratio of the solid powder to the ethanol water solution is 1: 30, of a nitrogen-containing gas; heating and stirring in a constant temperature water bath oscillator for extraction at 35 deg.C for 65 min; heating for extraction, filtering, and collecting filtrate.

Example 8.

The emollient is cyclomethicone, available from Anhui Aiyuta Silicone oil, Inc.

s1, adding the raw materials into a reaction container according to the formula amount, heating to 36 ℃, and stirring for 155min to obtain a first mixture;

s2, putting the mixture I into a high-speed shearing emulsifying machine, shearing and homogenizing for 25min under the condition that the rotating speed is 5000r/min to obtain a homogeneous liquid, detecting to be qualified, and subpackaging to obtain a finished ointment.

Example 9.

The emollient is cyclomethicone, available from Anhui Aiyuta Silicone oil, Inc.

s2, adding the traditional Chinese medicine components, the astringent, the adsorbent and the antioxidant into the first mixture according to the formula amount, heating to 40 ℃, stirring for 50min, then adding the repairing agent, and stirring for 55min to obtain a second mixture;

Example 10.

The emollient is cyclomethicone, available from Anhui Aiyuta Silicone oil, Inc.

s3, putting the mixture II into a high-speed shearing emulsifying machine, shearing and homogenizing for 25min under the condition that the rotating speed is 6000r/min to obtain a homogeneous liquid, detecting to be qualified, and subpackaging to obtain a finished ointment.

Comparative example 1.

An ointment containing Chinese medicinal components is prepared in the same manner as in example 1. The difference is that the weight portion of the traditional Chinese medicine components is 2.

Comparative example 2.

An ointment containing Chinese medicinal components is prepared in the same manner as in example 1. The difference is that the weight portion of the traditional Chinese medicine components is 15 portions.

Comparative example 3.

An ointment containing Chinese medicinal components is prepared in the same manner as in example 1. The difference lies in that the preparation method of the traditional Chinese medicine components comprises the following steps:

cleaning the Chinese medicinal materials, drying, pulverizing, and sieving with 60 mesh sieve to obtain the desired Chinese medicinal components.

Comparative example 4.

An ointment containing Chinese medicinal components is prepared in the same manner as in example 1. The difference is that the traditional Chinese medicine component is liquorice.

Comparative example 5.

An ointment containing Chinese medicinal components is prepared in the same manner as in example 1. The tea is characterized in that the weight ratio of the kudzu root to the baical skullcap root to the liquoric root to the apocynum is 1: 2.4: 4: 3.

comparative example 6.

An ointment containing Chinese medicinal components is prepared in the same manner as in example 1. The difference is that the humectant is lactose.

Comparative example 7.

An ointment containing Chinese medicinal components is prepared in the same manner as in example 1. The difference is that the repairing agent is calcium carbonate.

Comparative example 8.

An ointment containing Chinese medicinal components is prepared in the same manner as in example 1. The difference lies in that the weight ratio of the pearl powder to the mica powder is 1: 3.

comparative example 9.

An ointment containing Chinese medicinal components is prepared in the same manner as in example 1. The difference lies in that the above-mentioned

s1, adding a humectant, an emollient, calcium hydroxide, sodium carbonate and deionized water into a reaction vessel according to the formula amount, and stirring for 30min to obtain a mixture I;

s2, adding the traditional Chinese medicine components, the astringent, the adsorbent and the antioxidant into the first mixture according to the formula amount, heating to 26 ℃, stirring for 50min, then adding the repairing agent, and stirring for 60min to obtain a second mixture;

s3, putting the mixture into a high-speed shearing emulsifying machine, shearing and homogenizing for 30min under the condition that the rotating speed is 5000r/min to obtain a homogeneous liquid, detecting to be qualified, and subpackaging to obtain a finished ointment.

Comparative example 10.

An ointment containing Chinese medicinal components is prepared in the same manner as in example 1. The method is characterized in that S1, the humectant, the emollient, the calcium hydroxide, the sodium carbonate and the deionized water are added into a reaction vessel according to the formula amount, and the mixture is stirred for 30min to obtain a first mixture;

s2, adding the traditional Chinese medicine components, the astringent, the adsorbent and the antioxidant into the first mixture according to the formula amount, heating to 45 ℃, stirring for 50min, then adding the repairing agent, and stirring for 60min to obtain a second mixture;

Performance testing

1. 300 cases of patients with skin nevus and warts are randomly selected for clinical treatment, and statistical observation is carried out for 6 months, so that the ointment prepared in the embodiment 1 is found to obviously improve the defects of the nevus and the warts of the patients, the patients with the nevus, the warts, the plaques and the neoplasms falling off after 6 months reach 98%, and the patients with the new skin and the normal skin having no pigment difference reach 95%.

2. For example 1 and comparative examples 1 to 10, the following tests were carried out:

1) the ointment sample is sealed in a clean glass bottle and kept stand for 36 hours at 45 ℃, and the delamination condition of the sample is observed.

2) Randomly constructing 5 evaluation groups, applying the same amount of ointment on skin surface, and evaluating according to the texture of cream and whether the cream has greasy feeling, irritation feeling, etc., wherein the evaluation grade is from 0 (poor) to 5 (excellent).

	Layered situation	Sensory evaluation
			Example 1	Without delamination	5
Comparative example 1	Slight delamination	4
			Comparative example 2	Slight delamination	4
Comparative example 3	Apparent delamination	0
			Comparative example 4	Slight delamination	2
Comparative example 5	Slight delamination	4
			Comparative example 6	Slight delamination	3
Comparative example 7	Apparent delamination	1
			Comparative example 8	Apparent delamination	2
Comparative example 9	Apparent delamination	1
			Comparative example 10	Apparent delamination	2

Finally, it is pointed out that the foregoing examples are illustrative only, serving to explain some of the characteristics of the process according to the invention. The appended claims are intended to claim as broad a scope as is contemplated, and the examples presented herein are merely illustrative of selected implementations in accordance with all possible combinations of examples. Accordingly, it is applicants' intention that the appended claims are not to be limited by the choice of examples illustrating features of the invention. Also, where numerical ranges are used in the claims, subranges therein are included, and variations in these ranges are also to be construed as possible being covered by the appended claims.

Claims

1. An ointment containing traditional Chinese medicine components is characterized by comprising the following raw materials: 40-45 parts of deionized water, 3-8 parts of humectant, 1-5 parts of astringent, 0.3-1 part of emollient, 16-23 parts of calcium hydroxide, 16-22 parts of sodium carbonate, 10-15 parts of adsorbent, 0.2-1 part of repairing agent and 0.01-0.1 part of antioxidant.

2. The ointment containing traditional Chinese medicine components according to claim 1, characterized in that the raw materials of the ointment further comprise 5-12 parts of traditional Chinese medicine components.

3. The ointment of claim 2, wherein the herbal ingredients comprise at least one of pueraria lobata, coix seed, scutellaria baicalensis, glycyrrhiza uralensis, papermulberry fruit, and apocynum venetum.

4. The ointment of claim 1, wherein the moisturizer comprises at least one of lactose, trehalose, propylene glycol, glycerin, chitin derivatives, and sorbitol.

5. The ointment of claim 1, wherein the astringent comprises at least one of lactic acid, salicylic acid, and zinc p-hydroxybenzenesulfonate.

6. The ointment of claim 1, wherein the emollient comprises at least one of dimethicone, polymethylphenylsiloxane, and cyclic polysiloxane.

7. The ointment of claim 1, wherein the adsorbent comprises at least one of zinc stearate, polyethylene powder, cellulose microbeads, and magnesium hydroxide.

8. The ointment of claim 1, wherein the repairing agent comprises at least one of talc, calcium carbonate, wollastonite, pearl powder, mica powder, kaolin, and silica-alumina powder.

9. The ointment of claim 1, wherein the antioxidant comprises at least one of t-butyl hydroxyanisole, tocopherol acetate, ascorbic acid, di-t-butyl-p-cresol, and tea polyphenols.

10. Use of an ointment comprising a herbal component according to any one of claims 1 to 9, wherein the ointment is particularly suitable for the treatment of black nevi, meat nevi, subcutaneous nevi, blue nevi, freckles, subcutaneous plaques, age spots, pigmented spots, sweat spots, syringoma, whelks, comedones, acne, ichthyosis, verruca plana, verruca filiformis, verruca vulgaris, blackheads.