CN112469423A - 经间充质基质细胞外排体处理的单核细胞及其用途 - Google Patents

经间充质基质细胞外排体处理的单核细胞及其用途 Download PDF

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CN112469423A
CN112469423A CN201980031263.XA CN201980031263A CN112469423A CN 112469423 A CN112469423 A CN 112469423A CN 201980031263 A CN201980031263 A CN 201980031263A CN 112469423 A CN112469423 A CN 112469423A
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monocytes
isolated
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斯特兰·库雷姆巴纳斯
S·亚历山大·米特西利斯
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Boston Childrens Hospital
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
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    • C12N5/0645—Macrophages, e.g. Kuepfer cells in the liver; Monocytes
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CN201980031263.XA 2018-05-09 2019-05-09 经间充质基质细胞外排体处理的单核细胞及其用途 Pending CN112469423A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862669324P 2018-05-09 2018-05-09
US62/669,324 2018-05-09
PCT/US2019/031467 WO2019217646A1 (en) 2018-05-09 2019-05-09 Mesenchymal stromal cell exosome -treated monocytes and uses thereof

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CN112469423A true CN112469423A (zh) 2021-03-09

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US (1) US20210213056A1 (https=)
EP (1) EP3790560A4 (https=)
JP (2) JP2021522824A (https=)
CN (1) CN112469423A (https=)
CA (1) CA3099042A1 (https=)
WO (1) WO2019217646A1 (https=)

Cited By (2)

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Publication number Priority date Publication date Assignee Title
CN115475250A (zh) * 2022-05-26 2022-12-16 南京鼓楼医院 一种靶向肝星状细胞并抑制其激活的载药外泌体及其制备和应用
CN116999463A (zh) * 2022-04-27 2023-11-07 中山大学附属第三医院 一种间充质干细胞来源外泌体在制备治疗间质性膀胱炎药物中的应用

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CA2949083C (en) 2014-05-18 2023-10-10 Children's Medical Center Corporation Methods and compositions relating to exosomes
AU2018316166A1 (en) 2017-08-07 2020-02-06 The Regents Of The University Of California Platform for generating safe cell therapeutics
CN112334190B (zh) 2018-04-30 2024-09-20 儿童医学中心公司 间充质基质细胞外排体及其用途
WO2021145395A1 (ja) * 2020-01-15 2021-07-22 富士フイルム和光純薬株式会社 抗線維化剤、及び抗線維化作用を有する細胞外小胞の製造方法
WO2021145396A1 (ja) 2020-01-15 2021-07-22 富士フイルム和光純薬株式会社 血管新生剤、及び血管新生作用を有する細胞外小胞の製造方法
US20230248773A1 (en) 2020-07-09 2023-08-10 Exo Biologics Sa Extracellular Vesicles and Compositions Thereof
US20220127579A1 (en) * 2020-10-22 2022-04-28 Wisconsin Alumni Research Foundation Use of Toll-Like Receptor 4 Agonists to Treat Inflammation and Tissue Injury
TW202417616A (zh) * 2022-09-02 2024-05-01 財團法人醫藥工業技術發展中心 包含間質幹細胞的組成物在緩解骨髓纖維化上的用途

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US20100003272A1 (en) * 2007-01-11 2010-01-07 Inserm (Institut National De La Sante Et De La Recherche Medicale) Method for Expanding Monocytes
US20130273011A1 (en) * 2012-04-17 2013-10-17 Medistem, Inc. Stem cells and stem cell generated nanoparticles for treatment of inflammatory conditions and acute radiation syndrome
US20150190429A1 (en) * 2012-07-18 2015-07-09 Universitaet Duisburg-Essen Use of Preparations Comprising Exosomes Derived From Mesenchymal Stem Cells (MSCs) in the Prevention and Therapy of Inflammatory Conditions

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US10166254B2 (en) * 2014-09-19 2019-01-01 Wisconsin Alumni Research Foundation Use of mesenchymal stem cell-educated macrophages to treat and prevent graft versus host disease and radiation-induced injury
WO2018183825A1 (en) * 2017-03-31 2018-10-04 Wisconsin Alumni Research Foundation Generation of therapeutic cells using extracellular components of target organs
US10876753B2 (en) * 2018-02-12 2020-12-29 Watsco Ventures Llc Integrated sensor and service port for HVAC equipment or HVAC system

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US20100003272A1 (en) * 2007-01-11 2010-01-07 Inserm (Institut National De La Sante Et De La Recherche Medicale) Method for Expanding Monocytes
US20130273011A1 (en) * 2012-04-17 2013-10-17 Medistem, Inc. Stem cells and stem cell generated nanoparticles for treatment of inflammatory conditions and acute radiation syndrome
US20150190429A1 (en) * 2012-07-18 2015-07-09 Universitaet Duisburg-Essen Use of Preparations Comprising Exosomes Derived From Mesenchymal Stem Cells (MSCs) in the Prevention and Therapy of Inflammatory Conditions

Non-Patent Citations (2)

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MICHAEL A MATTHAY等: "Concise Review: Mesenchymal Stem (Stromal) Cells: Biology and Preclinical Evidence for Therapeutic Potential for Organ Dysfunction Following Trauma or Sepsis", 《STEM CELLS》, vol. 35, no. 2, pages 316 - 324, XP055651763, DOI: 10.1002/stem.2551 *
丁娟等: "hucMSCs源性外泌体对单核巨噬细胞生长及炎性因子IL-8、IL-12分泌水平的影响", 《华中科技大学学报（医学版）》, vol. 46, no. 1, pages 19 - 22 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116999463A (zh) * 2022-04-27 2023-11-07 中山大学附属第三医院 一种间充质干细胞来源外泌体在制备治疗间质性膀胱炎药物中的应用
CN115475250A (zh) * 2022-05-26 2022-12-16 南京鼓楼医院 一种靶向肝星状细胞并抑制其激活的载药外泌体及其制备和应用
CN115475250B (zh) * 2022-05-26 2024-03-26 南京鼓楼医院 一种靶向肝星状细胞并抑制其激活的载药外泌体及其制备和应用

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CA3099042A1 (en) 2019-11-14
JP2024163978A (ja) 2024-11-26
WO2019217646A1 (en) 2019-11-14
EP3790560A4 (en) 2022-03-30
EP3790560A1 (en) 2021-03-17
WO2019217646A8 (en) 2020-01-23
JP2021522824A (ja) 2021-09-02
US20210213056A1 (en) 2021-07-15

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