CN112451638A

CN112451638A - Chinese patent medicine pill for resisting hepatitis, enriching blood and detoxifying and preparation method and application thereof

Info

Publication number: CN112451638A
Application number: CN202011277723.8A
Authority: CN
Inventors: 侯爱丽
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-11-16
Filing date: 2020-11-16
Publication date: 2021-03-09

Abstract

The invention is applicable to the technical field of medicines, and provides a Chinese patent medicine pill for resisting hepatitis, enriching blood and detoxifying, and a preparation method and application thereof, wherein the Chinese patent medicine pill comprises the following components: radix Curcumae, radix Angelicae sinensis, Alumen, radix Ginseng, fructus Jujubae, semen Juglandis, Natrii sulfas, Massa Medicata Fermentata, Poria, fructus Gardeniae, herba Artemisiae Scopariae, and fructus Amomi. The invention adopts pure Chinese medicinal preparation, has no toxic or side effect, does not worry about disease rebound, and has the effects of resisting inflammation, supplementing potassium, nourishing qi, enriching blood, detoxifying, relieving pain, softening hardness, moistening dryness, clearing heat, reducing jaundice, invigorating stomach, strengthening body and effectively relieving liver tissue damage. The Chinese medicinal pill has definite therapeutic effects on hepatitis, liver cirrhosis, hepatosplenomegaly, liver pain, jaundice, transaminase, iron deficiency anemia, stamina insufficiency, sticky heat in mouth, deep yellow urine, regurgitation emesis, yellowish complexion, fatigue, abdominal pain, distention, epistaxis, deficiency of qi, blood and body fluid, etc.

Description

Chinese patent medicine pill for resisting hepatitis, enriching blood and detoxifying and preparation method and application thereof

Technical Field

The invention belongs to the technical field of medicines, and particularly relates to a Chinese patent medicine pill for treating liver diseases, and a preparation method and application thereof.

Background

For the treatment of liver diseases, the antiviral treatment is the key to the treatment of hepatitis B in western medicine. Once the indication is present and the condition is met, antiviral therapy must be performed. Although the treatment effect of taking the antiviral drugs is faster and better, once the drugs are stopped, the viruses are easily replicated again, and the disease is relapsed and rebounded. However, long-term administration of the drug will cause drug resistance variation, which can treat both symptoms and root causes. The problem is not worried about when taking traditional Chinese medicine. The traditional Chinese medicine is used for treating liver diseases by means of multi-way, multi-level and multi-target points such as liver protection, anti-inflammation, immunity regulation, hepatic fibrosis resistance and the like, and by differentiation of symptoms and signs, clinical symptoms are improved, liver functions are restored, the immune function of an organism is adjusted, the damage of liver pathological tissues is repaired, hepatic fibrosis is prevented, and HBV is inhibited or eliminated. Although there is no direct antiviral drug, the traditional Chinese medicine can regulate the functions of viscera and strengthen the healthy qi of human body, and the virus is killed by the method of improving human immunity to a great extent (no culture medium for virus growth is provided). Can also achieve the effect of inhibiting or eliminating viruses. Moreover, the traditional Chinese medicine has stable effects of reducing enzyme, removing jaundice, resisting virus and improving symptoms and small side effect, and is a treatment method worthy of recommendation, so the traditional Chinese medicine is undoubtedly the most safe and effective treatment method for liver diseases.

Disclosure of Invention

The embodiment of the invention aims to provide a Chinese patent medicine pill for resisting hepatitis, enriching blood and detoxifying, and aims to solve the problems in the background technology.

The embodiment of the invention is realized in such a way that the anti-hepatitis blood-enriching detoxifying Chinese patent medicine pill comprises the following components in parts by weight: 0.05 to 1 part of radix curcumae, 0.05 to 1 part of angelica, 0.05 to 0.5 part of alum, 0.05 to 1 part of ginseng, 0.05 to 1 part of Chinese date, 0.05 to 1 part of walnut, 0.05 to 0.5 part of mirabilite, 0.05 to 1 part of medicated leaven, 0.05 to 1 part of tuckahoe, 0.05 to 1 part of gardenia, 0.05 to 1 part of oriental wormwood and 0.05 to 1 part of fructus amomi.

As a preferable scheme of the embodiment of the invention, the Chinese patent medicine pill comprises the following components in parts by weight: 0.1 to 0.5 portion of curcuma aromatica, 0.1 to 0.5 portion of angelica, 0.1 to 0.3 portion of alum, 0.1 to 0.5 portion of ginseng, 0.1 to 0.5 portion of Chinese date, 0.1 to 0.5 portion of walnut, 0.1 to 0.3 portion of mirabilite, 0.1 to 0.5 portion of medicated leaven, 0.1 to 0.5 portion of tuckahoe, 0.1 to 0.5 portion of gardenia, 0.1 to 0.5 portion of oriental wormwood and 0.1 to 0.5 portion of fructus amomi.

As another preferable scheme of the embodiment of the invention, the Chinese patent medicine pill comprises the following components in parts by weight: 0.2 to 0.4 portion of radix curcumae, 0.2 to 0.4 portion of angelica, 0.15 to 0.25 portion of alum, 0.2 to 0.4 portion of ginseng, 0.2 to 0.4 portion of Chinese date, 0.2 to 0.4 portion of walnut, 0.15 to 0.25 portion of mirabilite, 0.2 to 0.4 portion of medicated leaven, 0.2 to 0.4 portion of tuckahoe, 0.2 to 0.4 portion of gardenia, 0.2 to 0.4 portion of oriental wormwood and 0.2 to 0.4 portion of fructus amomi.

Another object of the present invention is to provide a method for preparing the above Chinese patent medicine pill, which comprises the following steps:

weighing radix Curcumae, radix Angelicae sinensis, Alumen, Ginseng radix, fructus Jujubae, semen Juglandis, Natrii sulfas, Massa Medicata Fermentata, Poria, fructus Gardeniae, herba Artemisiae Scopariae, and fructus Amomi according to weight parts of each component;

steaming and boiling ginseng, drying and grinding the ginseng to obtain ginseng powder;

mixing radix Curcumae, radix Angelicae sinensis, Alumen, Natrii sulfas, Massa Medicata Fermentata, Poria, fructus Gardeniae, herba Artemisiae Scopariae, and fructus Amomi, grinding, and baking to obtain mixed powder;

pulverizing fructus Jujubae and semen Juglandis, mixing with Ginseng radix powder and mixed powder, and making into pill.

The other purpose of the embodiment of the invention is to provide the anti-inflammatory blood-enriching detoxifying pill prepared by the preparation method.

The embodiment of the invention also aims to provide application of the anti-inflammatory blood-enriching pill in preparation of a patent medicine.

The anti-hepatitis Chinese patent medicine pill provided by the embodiment of the invention completely adopts a pure Chinese medicine preparation, has no toxic or side effect, does not worry about the rebound of the disease, considers the liver as one of the five internal organs in the traditional Chinese medicine, has the functions of storing blood, inducing resuscitation, detoxifying and improving eyesight, and has the functions of treating and conditioning liver diseases, such as adjusting spirit, nourishing heart, treating temperament and the like. The pill aims at the above-mentioned production process, pill formula and formula proportion, and can play the effects of anti-inflammation potassium supplement, qi nourishing and blood enriching, detoxification and pain relief, hardness softening and dryness moistening, heat clearing and jaundice reducing, stomach invigorating and body building, and effective relief of liver tissue damage to the maximum extent. Through years of clinical practice, has exact curative effects on hepatitis, liver cirrhosis, hepatosplenomegaly, liver pain, jaundice, transaminase, iron-deficiency anemia, insufficiency of energy, sticky heat in the mouth, deep yellow urine, regurgitation, vomiting, yellowish complexion, fatigue, abdominal pain, fullness and distention, epistaxis, deficiency of qi, blood and body fluid and other symptoms.

Detailed Description

In order to clearly and completely describe the technical solutions in the embodiments of the present invention in combination with the embodiments of the present invention, it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Example 1

The embodiment provides a Chinese patent medicine pill for resisting hepatitis, enriching blood and detoxifying, and the preparation method comprises the following steps:

s1, weighing radix Curcumae 0.05kg, radix Angelicae sinensis 0.05kg, Alumen 0.05kg, radix Ginseng 0.05kg, fructus Jujubae 1kg, semen Juglandis 1kg, Natrii sulfas 0.05kg, Massa Medicata Fermentata 0.05kg, Poria 0.05kg, fructus Gardeniae 0.05kg, herba Artemisiae Scopariae 0.05kg, and fructus Amomi 0.05kg for use.

S2, cooking the ginseng to be cooked thoroughly, slicing, drying and grinding to obtain the ginseng powder.

S3, mixing the above weighed radix Curcumae, radix Angelicae sinensis, Alumen, Natrii sulfas, Massa Medicata Fermentata, Poria, fructus Gardeniae, herba Artemisiae Scopariae, and fructus Amomi, grinding, and baking to obtain mixed powder.

S4, crushing the weighed Chinese dates and walnuts, mixing the crushed Chinese dates and walnuts with the obtained ginseng powder and mixed powder, and preparing pills according to 5g of each pill to obtain the pills. The Chinese patent medicine has the outstanding characteristics of resisting inflammation, enriching blood, clearing away heat and toxic materials, tonifying spleen and lung, strengthening middle-jiao, benefiting qi, promoting the production of body fluid and soothing the nerves on the basis of the original curative effect.

Example 2

s1, weighing 1kg of radix curcumae, 1kg of angelica sinensis, 0.5kg of alum, 1kg of ginseng, 0.05kg of Chinese date, 0.05kg of walnut, 0.5kg of mirabilite, 1kg of medicated leaven, 1kg of poria cocos, 1kg of gardenia, 1kg of oriental wormwood and 1kg of fructus amomi for later use.

S4, crushing the weighed Chinese dates and walnuts, mixing the crushed Chinese dates and walnuts with the obtained ginseng powder and mixed powder, and preparing pills according to 5g of each pill to obtain the pills. The Chinese patent medicine has the outstanding characteristics of resisting inflammation and removing toxicity, enriching blood and removing blood stasis, benefiting gallbladder and reducing jaundice, relaxing bowel, clearing heat and promoting diuresis, and helping digestion and harmonizing stomach on the basis of the original curative effect.

Example 3

s1, weighing radix Curcumae 0.08kg, radix Angelicae sinensis 0.08kg, Alumen 0.08kg, radix Ginseng 0.08kg, fructus Jujubae 0.8kg, semen Juglandis 0.8kg, Natrii sulfas 0.08kg, Massa Medicata Fermentata 0.08kg, Poria 0.08kg, fructus Gardeniae 0.08kg, herba Artemisiae Scopariae 0.08kg, and fructus Amomi 0.08kg for use.

S4, crushing the weighed Chinese dates and walnuts, mixing the crushed Chinese dates and walnuts with the obtained ginseng powder and mixed powder, and preparing pills according to 5g of each pill to obtain the pills. The Chinese patent medicine has the outstanding characteristics of resisting inflammation, relieving pain, clearing away heat and toxic materials, moistening dryness, softening hard masses, promoting the production of body fluid, soothing the nerves, inducing diuresis, relieving swelling, invigorating stomach and benefiting spleen in the original curative effect.

Example 4

s1, weighing 0.8kg of radix curcumae, 0.8kg of angelica sinensis, 0.4kg of alum, 0.4kg of ginseng, 0.08kg of Chinese date, 0.08kg of walnut, 0.4kg of mirabilite, 0.8kg of medicated leaven, 0.8kg of poria cocos, 0.8kg of cape jasmine, 0.8kg of oriental wormwood and 0.8kg of fructus amomi for later use.

S4, crushing the weighed Chinese dates and walnuts, mixing the crushed Chinese dates and walnuts with the obtained ginseng powder and mixed powder, and preparing pills according to 5g of each pill to obtain the pills. The Chinese medicine has the outstanding features of diminishing inflammation, detoxicating, replenishing blood, benefiting vital energy, inducing diuresis to alleviate edema, benefiting gallbladder, lowering blood sugar, moistening intestine and relaxing bowels.

Example 5

s1, weighing radix Curcumae 0.1kg, radix Angelicae sinensis 0.1kg, Alumen 0.1kg, radix Ginseng 0.1kg, fructus Jujubae 0.5kg, semen Juglandis 0.5kg, Natrii sulfas 0.1kg, Massa Medicata Fermentata 0.1kg, Poria 0.1kg, fructus Gardeniae 0.1kg, herba Artemisiae Scopariae 0.1kg, and fructus Amomi 0.1kg for use.

S4, crushing the weighed Chinese dates and walnuts, mixing the crushed Chinese dates and walnuts with the obtained ginseng powder and mixed powder, and preparing pills according to 5g of each pill to obtain the pills. The Chinese patent medicine has the outstanding characteristics of resisting inflammation and removing toxicity, enriching blood and tonifying qi, clearing heat and promoting diuresis, inducing diuresis and reducing edema, relaxing bowel, promoting digestion and harmonizing stomach on the basis of the original curative effect.

Example 6

s1, weighing radix Curcumae 0.5kg, radix Angelicae sinensis 0.5kg, Alumen 0.3kg, radix Ginseng 0.5kg, fructus Jujubae 0.1kg, semen Juglandis 0.1kg, Natrii sulfas 0.3kg, Massa Medicata Fermentata 0.5kg, Poria 0.5kg, fructus Gardeniae 0.5kg, herba Artemisiae Scopariae 0.5kg, and fructus Amomi 0.5kg for use.

S4, pulverizing the above fructus Jujubae and semen Juglandis, mixing with the above radix Ginseng powder and mixed powder, and making into pill (5 g per pill) to obtain the final product. The Chinese patent medicine has the outstanding characteristics of resisting inflammation, enriching blood, clearing away heat and toxic materials, promoting bile flow, reducing jaundice, eliminating dampness, promoting qi circulation, promoting digestion and harmonizing stomach on the basis of the original curative effect.

Example 7

s1, weighing 0.2kg of radix curcumae, 0.2kg of angelica sinensis, 0.15kg of alum, 0.2kg of ginseng, 0.4kg of Chinese date, 0.4kg of walnut, 0.15kg of mirabilite, 0.2kg of medicated leaven, 0.2kg of poria cocos, 0.2kg of cape jasmine, 0.2kg of oriental wormwood and 0.2kg of fructus amomi for later use.

S4, crushing the weighed Chinese dates and walnuts, mixing the crushed Chinese dates and walnuts with the obtained ginseng powder and mixed powder, and preparing pills according to 5g of each pill to obtain the pills. The Chinese medicine has the outstanding features of diminishing inflammation, relieving pain, invigorating kidney, moistening lung, relaxing bowels, invigorating spleen and replenishing qi, restoring consciousness and benefiting spirit.

Example 8

s1, weighing 0.4kg of radix curcumae, 0.4kg of angelica sinensis, 0.25kg of alum, 0.4kg of ginseng, 0.2kg of Chinese date, 0.2kg of walnut, 0.25kg of mango, 0.4kg of medicated leaven, 0.4kg of poria cocos, 0.4kg of cape jasmine, 0.4kg of oriental wormwood and 0.4kg of fructus amomi for later use.

S4, crushing the weighed Chinese dates and walnuts, mixing the crushed Chinese dates and walnuts with the obtained ginseng powder and mixed powder, and preparing pills according to 5g of each pill to obtain the pills. The Chinese patent medicine has the outstanding characteristics of resisting inflammation and removing toxicity, promoting blood circulation and relieving pain, promoting the production of body fluid and soothing the nerves, benefiting gallbladder and reducing jaundice, relaxing bowel, helping digestion and harmonizing stomach on the basis of the original curative effect.

Example 9

s1, weighing 0.3kg of radix curcumae, 0.3kg of angelica sinensis, 0.3kg of alum, 0.3kg of ginseng, 0.3kg of Chinese date, 0.3kg of walnut, 0.3kg of mirabilite, 0.3kg of medicated leaven, 0.3kg of poria cocos, 0.3kg of cape jasmine, 0.3kg of oriental wormwood and 0.3kg of fructus amomi for later use.

S4, crushing the weighed Chinese dates and walnuts, mixing the crushed Chinese dates and walnuts with the obtained ginseng powder and mixed powder, and preparing pills according to 5g of each pill to obtain the pills. The Chinese patent medicine has the outstanding characteristics of resisting inflammation, enriching blood, moistening dryness, softening hardness, tonifying middle-jiao and Qi, benefiting gallbladder, reducing jaundice, inducing diuresis and reducing edema on the basis of the original curative effect.

The Chinese medicinal pill for treating hepatitis is black granule, and has no odor and slightly bitter taste.

Indications are as follows: acute and chronic hepatitis, hepatic ascites, liver cirrhosis, hepatosplenomegaly, liver pain, three positive and small positive, jaundice, transaminase, zinc sulfate, sticky heat in mouth, deep yellow urine, regurgitation, emesis, abdominal pain, hemorrhage, deficiency of qi, blood and body fluid.

The usage and dosage are as follows: is administered orally. The granule is taken by 1 granule for adult three times a day half an hour after meal.

Adverse reactions: patients have better tolerance to the product and lower incidence rate of adverse reactions. The common adverse reaction is slight diarrhea with cold abdomen when the traditional Chinese medicine preparation is taken for the first time, and the dosage can be reduced according to the medical advice, and the dosage reaches the normal after the traditional Chinese medicine preparation is adapted.

Contraindications are as follows: beef and horse, female pork, pumpkin, spicy, tobacco wine, uncooked and cold food, etc.

Test example:

first, the results of DNA detection of hepatitis B virus of a patient with liver disease before and after taking the anti-hepatitis pill provided in example 9 are shown in Table 1.

TABLE 1

And secondly, comparing the color ultrasonic diagnosis results before and after taking the medicine.

1. The results of color ultrasonic diagnosis of liver before taking the anti-inflammatory, blood-enriching and detoxifying pill provided in example 9 for a patient with liver disease are as follows:

ultrasonic observation: the liver is slightly small, the shape is normal, the surface is uneven, the lower edge angle of the liver becomes pure, the light spots of the liver parenchyma are thickened, increased and disordered, the distribution is uneven, and no obvious occupation is seen. The hepatic vein becomes thin, and the intrahepatic bile duct is not expanded. There was no dilation of the main portal vein, no internal exploration and substantial echo. CDFI: the portal vein is the blood flow into the liver.

The cut section of the gallbladder is normal in size and shape, the wall is not thick, and no obvious calculus or tumor is found in the gallbladder. The common bile duct did not dilate. CDFI: the gallbladder wall has no abnormal blood flow signal.

The section of pancreas is normal in size and shape, the parenchyma echo is uniform, obvious space occupying lesion is not seen, and the main pancreatic duct is not obviously expanded. CDFI: an abnormal blood flow signal is indicated.

The spleen was removed.

The section of the double kidneys is normal in size and shape, the parenchyma echoes are uniform, no space occupying lesion is seen, the integration system is not separated, and no abnormal echogenic clique is seen. CDFI: the kidney blood flow is well perfused and distributed in finger shape and is uniform.

No expansion of bilateral ureters was observed.

Ultrasonic diagnosis:

diffuse lesions of the liver (cirrhosis acoustic image);

no obvious abnormality is seen in the biliary, membranous and double renal echoes;

no expansion of bilateral ureters was observed.

2. The results of color ultrasonic diagnosis of liver after taking the anti-inflammatory, blood-enriching and detoxifying pill provided in example 9 for a patient with liver disease are as follows:

ultrasonic observation: the liver has normal size and shape, smooth liver envelope line, thickened light spots in the liver, uniform distribution, clear display of blood vessels in the liver, normal diameter of hepatic veins and normal running. The diameter of the portal vein is normal, the wall of the portal vein is smooth and continuous, and abnormal echo is not seen in the lumen.

The gallbladder has normal size and shape, smooth wall, no pathological change of occupying space in gallbladder cavity, and no expansion of common bile duct.

The spleen is normal in size and shape, the envelope is complete and smooth, the internal echo is uniform, and the internal diameter of the splenomegaly vein is normal.

The pancreas has normal size and shape, smooth contour line, uniform internal echo, no real light mass or liquid dark area, and no expansion of the main pancreatic duct.

The shape and the size of the double kidneys are normal, the envelopes are smooth and complete, the skin and the marrow are clearly demarcated, no real light mass or liquid dark areas are seen in the essence, and no separation and abnormal echo are seen in the echo of the kidney assembly system.

CDFI: no detectable and significant abnormal blood flow signals.

Ultrasonic prompting: the liver parenchymal light spots thicken the image. No abnormalities were found in the biliary, spleen, pancreas, and kidneys.

Thirdly, the results of five hepatitis B virus indicators before and after taking the anti-hepatitis pill provided in example 9 are shown in Table 2.

TABLE 2

Item	Test results before taking medicine	Test results after taking medicine	Reference value	Unit of
					Hepatitis B virus surface antigen	55.09	42.43	0~0.05	IU/mL
Hepatitis B virus surface antibody	2.04	2.30	0~10	mIU/mL
					Hepatitis B virus e antigen	200.91	0.38	0~1	S/CO
Hepatitis B virus e antibody	12.44	0.01	＞1	S/CO
					Hepatitis B virus core antibody	8.48	10.33	0~1	S/CO

Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.

Claims

1. The Chinese patent medicine pill for resisting hepatitis, enriching blood and detoxifying is characterized by comprising the following components in parts by weight: 0.05 to 1 part of radix curcumae, 0.05 to 1 part of angelica, 0.05 to 0.5 part of alum, 0.05 to 1 part of ginseng, 0.05 to 1 part of Chinese date, 0.05 to 1 part of walnut, 0.05 to 0.5 part of mirabilite, 0.05 to 1 part of medicated leaven, 0.05 to 1 part of tuckahoe, 0.05 to 1 part of gardenia, 0.05 to 1 part of oriental wormwood and 0.05 to 1 part of fructus amomi.

2. The anti-hepatitis blood-enriching detoxifying Chinese patent medicine pill as claimed in claim 1, which is characterized by comprising the following components in parts by weight: 0.1 to 0.5 portion of curcuma aromatica, 0.1 to 0.5 portion of angelica, 0.1 to 0.3 portion of alum, 0.1 to 0.5 portion of ginseng, 0.1 to 0.5 portion of Chinese date, 0.1 to 0.5 portion of walnut, 0.1 to 0.3 portion of mirabilite, 0.1 to 0.5 portion of medicated leaven, 0.1 to 0.5 portion of tuckahoe, 0.1 to 0.5 portion of gardenia, 0.1 to 0.5 portion of oriental wormwood and 0.1 to 0.5 portion of fructus amomi.

3. The anti-hepatitis blood-enriching detoxifying Chinese patent medicine pill as claimed in claim 1, which is characterized by comprising the following components in parts by weight: 0.2 to 0.4 portion of radix curcumae, 0.2 to 0.4 portion of angelica, 0.15 to 0.25 portion of alum, 0.2 to 0.4 portion of ginseng, 0.2 to 0.4 portion of Chinese date, 0.2 to 0.4 portion of walnut, 0.15 to 0.25 portion of mirabilite, 0.2 to 0.4 portion of medicated leaven, 0.2 to 0.4 portion of tuckahoe, 0.2 to 0.4 portion of gardenia, 0.2 to 0.4 portion of oriental wormwood and 0.2 to 0.4 portion of fructus amomi.

4. A method for preparing the anti-inflammatory, blood-enriching and detoxifying pill as claimed in any one of claims 1 to 3, comprising the following steps:

5. An anti-inflammatory blood-enriching detoxification pill prepared by the preparation method of claim 4.

6. Use of the anti-inflammatory blood-enriching detoxifying pill as claimed in any one of claims 1-3 and 5 in preparation of a medicament.