CN108042755A - It is a kind of to be used to treat weakness of the spleen and the stomach oral traditional Chinese medicine composition and its application - Google Patents
It is a kind of to be used to treat weakness of the spleen and the stomach oral traditional Chinese medicine composition and its application Download PDFInfo
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Classifications
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Abstract
The invention discloses a kind of raw material components treated weakness of the spleen and the stomach oral traditional Chinese medicine composition, include following parts by weight：9~21 parts of radix pseudostellariae, 6~14 parts of Rhizoma Atractylodis Macrocephalae, 15~35 parts of Poria cocos, Charred Triplet are 18~42 parts each, 9~21 parts of the membrane of a chicken's gizzard, 6~14 parts of Radix Aucklandiae, 6~14 parts of fructus amomi, 3~7 parts of Radix Glycyrrhizae.It is evident in efficacy and without any side effects provided by the present invention for treating weakness of the spleen and the stomach oral traditional Chinese medicine composition, it can be used for treating weakness of the spleen and the stomach, there is good therapeutic effect.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to it is a kind of for treat weakness of the spleen and the stomach oral traditional Chinese medicine composition and
It is applied.
Background technology
It is weakness of the spleen and the stomach, it is traditional chinese medical term term.Weakness of the spleen and the stomach meaning is more general, contains Spleen-Qi Deficiency, insufficiency of the spleen-yang, spleen not
The tcm syndromes such as system blood, the sinking of qi of middle-jiao, the stomach deficiency of yang, stomach Qi deficiency, stomach-Yin deficiency and deficiency-cold in spleen and stomach.Wherein Spleen-Qi Deficiency is weakness of the spleen and the stomach
Fundamental type, syndrome of deficiency of spleen qi refer to deficiency of spleen-QI, lose the showed syndrome of its strong fortune.Mostly because of eating and drinking without temperance, overwork, prolonged illness
Caused by wasting spleen-QI.Weakness of the spleen and the stomach common clinical manifestation：The course of disease is longer, when diarrhea, is light weight or when stop when sending out, stool is dilute
Half congealed, the light odorless of color accompanies indigestion swill, is easily rushed down after food, sees that abdominal distension, stool are more after eating mostly, loses the appetite usually, face
Color is sallow, tired, and body is thin and weak, and tongue nature is light, and tongue is thin white, Weak pulse.
One of effective means to weakness of the spleen and the stomach progress complex treatment using Chinese medicine compound prescription, treat it is weakness of the spleen and the stomach it is for oral administration in
The research and development and invention of medicine compound are of great significance to the mankind and society.
The content of the invention
There are significant curative effect and Chinese medicine group without side-effects to weakness of the spleen and the stomach the technical problem to be solved by the present invention is to provide a kind of
Close object and its application.
First purpose of the present invention be to provide it is a kind of for treating weakness of the spleen and the stomach oral traditional Chinese medicine composition, including following
The raw material components of parts by weight：9~21 parts of radix pseudostellariae, 6~14 parts of Rhizoma Atractylodis Macrocephalae, 15~35 parts of Poria cocos, Charred Triplet are 18~42 parts each, chicken
Interior golden 9~21 parts, 6~14 parts of Radix Aucklandiae, 6~14 parts of fructus amomi, 3~7 parts of Radix Glycyrrhizae.
Preferably, the present invention provides and is put into treat weakness of the spleen and the stomach oral traditional Chinese medicine composition, including following parts by weight
Several raw material components：15 parts of radix pseudostellariae, 10 parts of Rhizoma Atractylodis Macrocephalae, 25 parts of Poria cocos, Charred Triplet are 30 parts each, 15 parts of the membrane of a chicken's gizzard, 10 parts of Radix Aucklandiae, sand
10 parts of benevolence, 5 parts of Radix Glycyrrhizae.
Preferably, the Charred Triplet is melanoidin malt, charred FRUCTUS CRATAEGI and stir-baked MASSA FERMENTATA MEDICI-NALIS.
Second object of the present invention, which is to provide, above-mentioned is preparing spleen for treating weakness of the spleen and the stomach oral traditional Chinese medicine composition
Application in stomach weakness pharmaceutical preparation.
Preferably, the pharmaceutical dosage form of the pharmaceutical preparation is tablet, capsule, granule, Disket or pill.
Fourth object of the present invention be to provide it is above-mentioned for treat weakness of the spleen and the stomach oral traditional Chinese medicine composition prepare eat
Application in product, cosmetics, articles for washing or toothpaste.
The pharmacological action of each component in the present composition：
Radix pseudostellariae is monarch drug in a prescription, sweet in flavor, slight bitter, mild-natured；Enter the heart, spleen, lung three to pass through.Energy tonifying Qi benefit spleen, nourishing Yin and promoting production of body fluid.Rhizoma Atractylodis Macrocephalae is
Ministerial drug, invigorating the spleen, eliminating dampness, to help transporting and radix pseudostellariae, to enhance the work(to replenish qi to invigorate the spleen of radix pseudostellariae.Adjutant is good for for Poria cocos excreting dampness
Spleen, Siberian cocklebur art share, and promote the enhancing of the power of invigorating the spleen dehumidifying and transporting；Charred Triplet, i.e. melanoidin malt, charred FRUCTUS CRATAEGI, stir-baked MASSA FERMENTATA MEDICI-NALIS.This three taste
Medicine has the stagnant function of good disperse accumulationization, but has the characteristics of respective difference.Melanoidin malt has good digestible starch group food
Effect；Charred FRUCTUS CRATAEGI is good at treating meat or greasy excessive caused food stagnation；Stir-baked MASSA FERMENTATA MEDICI-NALIS is then beneficial to digestion rice and flour food；Three medicines close
With can significantly enhance digestive function.The membrane of a chicken's gizzard is sweet, trembles with fear.Returns spleen, stomach, small intestine, bladder warp, food digesting stomach fortifying is aid digestion, and puckery essence is stopped
It loses.It can promote gastric secretion, improve gastric acidity and eupepsy, stomach motor function is remarkably reinforced, rapid gastric emptying.The medicine is set to be
Radix Aucklandiae acrid flavour, hardship, it is warm-natured；Returns spleen, stomach, liver, large intestine channel, fragrant row dissipate, and can rise can drop；Promoting qi circulation and relieving pain, qi-regulating is soothing the liver, and invigorating the spleen disappears
It is stagnant.Fructus amomi acrid flavour, it is warm-natured；Converge to the spleen channel, stomach, kidney channel；Dampness elimination appetizing, warming spleen and stopping diarrha, regulating the flow of vital energy antiabortive.Radix Glycyrrhizae, Gan Wen can be adjusted all
Medicine allows them to play the effect of air making-up and spleen enlivening jointly.All medicines share replenishes qi to invigorate the spleen, promoting digestion；For deficiency of spleen-QI and stomach-QI, stomach is received not
Good abdominal distension and anorexia, anorexia and loose stool, shortness of breath and fatigue.
Compared with prior art, the beneficial effects of the present invention are：
It is evident in efficacy and without any side effects provided by the present invention for treating weakness of the spleen and the stomach oral traditional Chinese medicine composition,
Can be not only used for treating the preparation of weakness of the spleen and the stomach drug, be alternatively arranged as Dietotherapy medicament be processed into food or be applied to cosmetics,
Articles for washing, toothpaste preparation process in.
Specific embodiment
In order to which those skilled in the art is enable to more fully understand, technical scheme is practiced, with reference to specific
The invention will be further described for embodiment, but illustrated embodiment is not as a limitation of the invention.
Be not specified the test method of actual conditions in embodiments below, according to this field conventional method and condition into
Row, raw materials used is commercially available.
Embodiment 1
The present embodiment is a kind of for treating weakness of the spleen and the stomach oral traditional Chinese medicine composition, the raw material group including following parts by weight
Point：15 parts of radix pseudostellariae, 10 parts of Rhizoma Atractylodis Macrocephalae, 25 parts of Poria cocos, Charred Triplet are 30 parts each, 15 parts of the membrane of a chicken's gizzard, 10 parts of Radix Aucklandiae, 10 parts of fructus amomi, sweet
5 parts of grass.
The preparation process of above-mentioned Chinese medicine composition is very simple, after each raw material components are weighed in proportion, carries out powder respectively
Broken, the raw material after crushing is uniformly mixed, and according to the conventional production process of pharmaceutical formulation carries out that tablet is made.
Embodiment 2
The present embodiment is a kind of for treating weakness of the spleen and the stomach oral traditional Chinese medicine composition, the raw material group including following parts by weight
Point：9 parts of radix pseudostellariae, 8 parts of Rhizoma Atractylodis Macrocephalae, 15 parts of Poria cocos, Charred Triplet are 20 parts each, 9 parts of the membrane of a chicken's gizzard, 6 parts of Radix Aucklandiae, 6 parts of fructus amomi, 4 parts of Radix Glycyrrhizae.
It after above-mentioned each raw material components are weighed in proportion, crushes respectively, the raw material after crushing is uniformly mixed, according to medicine
With the conventional production process of preparation carry out that capsule is made.
Embodiment 3
The present embodiment is a kind of for treating weakness of the spleen and the stomach oral traditional Chinese medicine composition, the raw material group including following parts by weight
Point：21 parts of radix pseudostellariae, 14 parts of Rhizoma Atractylodis Macrocephalae, 30 parts of Poria cocos, Charred Triplet are 42 parts each, 18 parts of the membrane of a chicken's gizzard, 14 parts of Radix Aucklandiae, 14 parts of fructus amomi, sweet
7 parts of grass.
It after above-mentioned each raw material components are weighed in proportion, crushes respectively, the raw material after crushing is uniformly mixed, according to medicine
With the conventional production process of preparation carry out that granule is made.
Embodiment 4
The present embodiment is a kind of for treating weakness of the spleen and the stomach oral traditional Chinese medicine composition, the raw material group including following parts by weight
Point：18 parts of radix pseudostellariae, 10 parts of Rhizoma Atractylodis Macrocephalae, 35 parts of Poria cocos, Charred Triplet are 25 parts each, 21 parts of the membrane of a chicken's gizzard, 12 parts of Radix Aucklandiae, 12 parts of fructus amomi, sweet
3 parts of grass.
It after above-mentioned each raw material components are weighed in proportion, crushes respectively, the raw material after crushing is uniformly mixed, according to medicine
With the conventional production process of preparation carry out that pill is made.
Examples 1 to 4 prepared work well for treating weakness of the spleen and the stomach preparation, due to Examples 1 to 4 system
It is standby go out weakness of the spleen and the stomach preparation effect is substantially parallel for treating, therefore the Chinese medicine preparation prepared only with embodiment 1 comes
The effect of the present invention is illustrated.
Further the effect of the present invention is illustrated using animal experiment and clinical test below.
First, animal experiment
1st, acute toxicity testing
Using NIH mouse 60, SPF grades, half male and half female, weight 18-22g carries out acute toxicity test.Mouse is divided at random
For two groups, every group 30, i.e. control group and administration group, when fasting 12 is small before experiment；The embodiment of the present invention 1 is prepared into treatment spleen
In water, (concentration be 6g crude drugs/mL, maximum concentration) gavage, gavage volume is 5mL/kg (i.e. singles to the tablet dissolved of stomach weakness
Dosage is 30g crude drugs/kg), control group gives normal saline, is administered 2 times within one day, when delivery time 6 is small, gives
It is observed continuously after medicine 14 days, and records the toxic reaction and death toll of mouse.
The experimental results showed that：Compared with the control group, mouse has no notable difference after administration, and experiment is observed continuously 14 days, small
Mouse body condition, diet, drinking water and weight gain is normal.The Mouse oral gavage present invention treats weakness of the spleen and the stomach tablet LD50
＞ 30g crude drugs/kg, daily maximum dosage-feeding are 60g crude drugs/kg/ days.The clinical use of Chinese medicine preparation prepared by the embodiment of the present invention 1
Dose is 12g crude drugs/day/people, and for adult's weight in terms of 60kg, average dosage is 0.2g crude drugs/kg/ days.By batheroom scale：It is small
The dosis tolerata of the Chinese medicine preparation of mouse (average weight is counted using 20g) oral administration gavage present invention is 300 times of quantity.Therefore this hair
Bright Chinese medicine preparation acute toxicity is low, clinical application safety.
2nd, long term toxicity test
The embodiment of the present invention 1 prepare treat weakness of the spleen and the stomach tablet to mouse by 10.02g, 20.35g and 33.48g crude drug/
It kg continuous uses 10 weeks (1.0mL/100g weight, 2 times a day) and mouse is observed, is detected after being discontinued 4 weeks.
The experimental results showed that：Prepared by the embodiment of the present invention 1 is used to treat hair, row of weakness of the spleen and the stomach tablet to rat
It is had no significant effect for indexs such as, stool and urine, weight, organ weights, blood picture, hepatic and renal function, blood glucose, blood fat, internal organs naked eyes do not have
Be found it is abnormal variation and histological indications show medication 10 weeks and be discontinued 4 weeks after, each internal organs of rat nothing substantially change
Become.Illustrate prepared by the embodiment of the present invention 1 and treat weakness of the spleen and the stomach tablet to small toxicity after rat long-term administration, also do not have after drug withdrawal
Abnormal reaction, application are safe.
2nd, clinical test
1st, clinical case
The weakness of the spleen and the stomach diseases person made a definite diagnosis is development test object, chooses 95 clinical cases, wherein male 58, women 37
Example, eldest 69 years old, 27 years old minimum, volunteer had to comply with《The dialectical normative reference of the traditional Chinese medical science chronic diseases marked by deficiency of vital energy》Requirement be diagnosed as taste
Weak disease, other patients cannot participate in this experiment.
2nd, therapy
The tablet that the embodiment of the present invention 1 is prepared is taken during treatment, warm water takes, and respectively takes once daily morning and evening, one
Secondary 2, a piece of 3g, treatment cycle is 4 weeks.
3rd, treatment effectiveness evaluation：
It is effective：Symptom significantly reduces before relatively treating after treatment, and every Index for examination returns to normal.
Effectively：Symptom is reduced after treatment, and indices improve.
It is invalid：Each symptom is not improved after treatment.
4th, experimental result
71 to fully recover in 95 patients, effective 24, total effective rate is up to 100%, through treating a course for the treatment of (4 weeks)
Afterwards, disease is removed and is cured.
5th, model case
(1) Spleen-Qi Deficiency case：Man, 45 years old, abdominal fullness and distention after diagnosing, for very, mouth does not know taste or even do not feel like eating after food,
Big loose stool is thin, and lassitude, body is become thin, limbs burnout, deficiency of QI with disinclination to talk, sallow complexion or white or limbs edema, pale tongue tongue
In vain, arteries and veins delays weak powerless.It takes other medicines not improving, takes the embodiment of the present invention 1 and prepare weakness of the spleen and the stomach piece for the treatment of
After totally 5 days, above-mentioned symptom disappears for agent.
(2) insufficiency of the spleen-yang case：Female, 27 years old, abdominal distention and anorexia, continuous and dull pain in the abdomen was liked temperature happiness and is pressed, and shape is trembled with fear, and limb is cold, and big loose stool is thin clear
Dilute, the more matter of leukorrhea are dilute, and tongue nature is light fat, white,slippery and moist fur, and slow and sunken pulse is powerless.It is weakness of the spleen and the stomach to take the preparation treatment of the embodiment of the present invention 1
Tablet is after totally 3 days, and remission continues to take 4 days, and all symptoms disappear.
(3) sinking of qi of middle-jiao case：Man, 30 years old, pale white complexion, the easy sweat of dizziness was losed heart, burnout, deficiency of food, loose stool, abdomen weight
Pendant, awareness of defecation frequency.It takes the embodiment of the present invention 1 and prepares weakness of the spleen and the stomach tablet for the treatment of after totally 6 days, food-intake increases, and stool is just
Often, the sense of abdomen falling inflation disappears.
(4) failure of the spleen to keep the blood flowing within the vessels case：Female, 31 years old, deficiency of food, abdominal distension, loose stool, limbs burnout, deficiency of QI with disinclination to talk, sallow complexion, the moon
Through excessive, pale tongue with white fur, arteries and veins delays weak.Taking weakness of the spleen and the stomach tablet of the preparation treatment of the embodiment of the present invention 1, all diseases are equal after totally 5 days
Disappear.
(5) deficiency of the spleen-yin case：Man, 30 years old, dry mouth and lips was noisy, retched, and diet reduces or dysphagia, eats metathorax diaphragm
Discomfort, dry and hard excrement, the red center of tongue are done, few tongue, thready rapid pulse etc..It takes the embodiment of the present invention 1 and prepares weakness of the spleen and the stomach piece for the treatment of
Agent is after totally 4 days, and all symptoms disappear.
To sum up, Chinese prescription of the present invention is reasonable, at low cost, drug convenient material drawing, preparation are simple, short treating period, treatment
Effect is significantly, cure rate is high, has no toxic side effect.
It should be noted that involved in claims of the present invention during numberical range, it is thus understood that each numberical range
Any one numerical value can be selected between two endpoints and two endpoints, due to step method and the embodiment 1-4 phases of use
Together, repeat in order to prevent, description of the invention preferred embodiment, but those skilled in the art once know substantially
Creative concept can then make these embodiments other change and modification.So appended claims are intended to be construed to wrap
It includes preferred embodiment and falls into all change and modification of the scope of the invention.
Obviously, various changes and modifications can be made to the invention without departing from essence of the invention by those skilled in the art
God and scope.In this way, if these modifications and changes of the present invention belongs to the scope of the claims in the present invention and its equivalent technologies
Within, then the present invention is also intended to comprising including these modification and variations.
Claims (6)
1. a kind of be used to treat weakness of the spleen and the stomach oral traditional Chinese medicine composition, which is characterized in that includes the raw material of following parts by weight
Component：9~21 parts of radix pseudostellariae, 6~14 parts of Rhizoma Atractylodis Macrocephalae, 15~35 parts of Poria cocos, Charred Triplet are 18~42 parts each, 9~21 parts of the membrane of a chicken's gizzard, wood
6~14 parts fragrant, 6~14 parts of fructus amomi, 3~7 parts of Radix Glycyrrhizae.
2. according to claim 1 be used to treat weakness of the spleen and the stomach oral traditional Chinese medicine composition, which is characterized in that including following
The raw material components of parts by weight：15 parts of radix pseudostellariae, 10 parts of Rhizoma Atractylodis Macrocephalae, 25 parts of Poria cocos, Charred Triplet are 30 parts each, 15 parts of the membrane of a chicken's gizzard, Radix Aucklandiae
10 parts, 10 parts of fructus amomi, 5 parts of Radix Glycyrrhizae.
3. according to claim 1 or 2 be used to treat weakness of the spleen and the stomach oral traditional Chinese medicine composition, which is characterized in that described
Charred Triplet is melanoidin malt, charred FRUCTUS CRATAEGI and stir-baked MASSA FERMENTATA MEDICI-NALIS.
4. according to claim 1 or 2 preparing weakness of the spleen and the stomach medicine for treating weakness of the spleen and the stomach oral traditional Chinese medicine composition
Application in object preparation.
5. application according to claim 4, which is characterized in that the pharmaceutical dosage form of the pharmaceutical preparation for tablet, capsule,
Granule, Disket or pill.
6. according to claim 1 or 2 preparing food, makeup for treating weakness of the spleen and the stomach oral traditional Chinese medicine composition
Application in product, articles for washing or toothpaste.
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| CN110090282A (en) * | 2019-03-27 | 2019-08-06 | 中国中医科学院西苑医院 | For mitigating the Chinese medicine composition of gastrointestinal tract toxicity |
| CN110624066A (en) * | 2019-11-05 | 2019-12-31 | 宋小冰 | Traditional Chinese medicine for treating infantile anorexia |
| CN115944699A (en) * | 2022-12-14 | 2023-04-11 | 修正药业集团股份有限公司 | Traditional Chinese medicine composition with effects of activating spleen, tonifying qi, promoting digestion and removing food stagnation as well as preparation method and application thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110090282A (en) * | 2019-03-27 | 2019-08-06 | 中国中医科学院西苑医院 | For mitigating the Chinese medicine composition of gastrointestinal tract toxicity |
| CN110624066A (en) * | 2019-11-05 | 2019-12-31 | 宋小冰 | Traditional Chinese medicine for treating infantile anorexia |
| CN115944699A (en) * | 2022-12-14 | 2023-04-11 | 修正药业集团股份有限公司 | Traditional Chinese medicine composition with effects of activating spleen, tonifying qi, promoting digestion and removing food stagnation as well as preparation method and application thereof |
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Application publication date: 20180518 |