CN112402686A - Easily degradable collagen line and preparation method thereof - Google Patents
Easily degradable collagen line and preparation method thereof Download PDFInfo
- Publication number
- CN112402686A CN112402686A CN202011428881.9A CN202011428881A CN112402686A CN 112402686 A CN112402686 A CN 112402686A CN 202011428881 A CN202011428881 A CN 202011428881A CN 112402686 A CN112402686 A CN 112402686A
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- China
- Prior art keywords
- collagen fiber
- fiber silk
- collagen
- layer
- silk thread
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
- A61L17/08—At least partially resorbable materials of animal origin, e.g. catgut, collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/14—Post-treatment to improve physical properties
Abstract
The invention relates to an easily degradable collagen thread which comprises an inner collagen fiber silk thread, an outer collagen fiber silk thread and a sericin layer, wherein the outer collagen fiber silk thread is provided with a plurality of outer collagen fiber silk threads, the outer collagen fiber silk threads are parallel to each other and spirally wound on the surface of the inner collagen fiber silk thread to form an outer layer, and the surface of the outer layer is provided with a sericin layer. The invention also provides a preparation method of the easily degradable collagen line. The invention has the following beneficial effects: the requirement of tension during sewing is met, the inner layer collagen fiber silk thread, the outer layer collagen fiber silk thread and the sericin layer are all made of materials which can be absorbed by human bodies, so that the materials can be absorbed by patients conveniently, and meanwhile, the sewing thread has the advantages of no stimulation, no toxic or side effect and no scar at the stitch position of the healed sewing thread.
Description
Technical Field
The invention relates to an easily degradable collagen line and a preparation method thereof, belonging to the technical field of production and manufacturing of collagen lines.
Background
An absorbable suture line refers to a novel suture material which can be degraded and absorbed by a human body after being implanted into human tissues in the process of surgical suture, does not need to be removed, and is free from the pain of removing the suture.
However, the existing absorbable suture line has insufficient tension, is knotted and easy to break during suturing, is easy to be absorbed without wound healing, and causes the wound rupture accident, thereby bringing worry and worry to doctors clinically.
Disclosure of Invention
According to the defects in the prior art, the technical problems to be solved by the invention are as follows: in order to solve one of the problems, the degradable collagen thread and the preparation method thereof are provided.
The easily degradable collagen line is characterized in that: including inlayer collagen fiber silk thread, outer collagen fiber silk thread and sericin layer, outer collagen fiber silk thread is provided with many, many outer collagen fiber silk threads are parallel to each other and are the heliciform winding in the surface of inlayer collagen fiber silk thread, form the outer layer, outer surface has the sericin layer.
Preferably, the outer collagen fiber thread is provided with at least eight.
Preferably, the adjacent outer collagen fiber threads of each circle are closely arranged.
Preferably, the inner collagen fiber thread has a plurality of inner collagen fiber threads, and the plurality of inner collagen fiber threads are parallel to each other to form a bundle-like structure.
Preferably, the diameter of the inner collagen fiber filament is larger than that of the outer collagen fiber filament.
Preferably, the inner collagen fiber filament has the same diameter as the outer collagen fiber filament.
Preferably, the thickness of the sericin layer is 0.1-0.5 mm.
Preferably, the inner collagen fiber filament is not equal in diameter to the outer collagen fiber filament.
The invention also provides a preparation method of the easily degradable collagen thread, wherein a plurality of inner layer collagen fiber silk threads are arranged in parallel to form a bundle-shaped structure, a plurality of outer layer collagen fiber silk threads are wound on the outer side of the bundle-shaped structure, the plurality of outer layer collagen fiber silk threads are parallel to each other and spirally wound on the surface of the inner layer collagen fiber silk threads to form an outer layer, and finally, a silk glue layer is poured on the outer side of the outer layer, so that the fracture of the suture thread is reduced.
Preferably, the inner collagen fiber thread, the outer collagen fiber thread and the sericin layer are made of materials which can be absorbed by a human body.
Compared with the prior art, the invention has the following beneficial effects:
the easily degradable collagen thread meets the requirement of tension during sewing, and the inner layer collagen fiber silk thread, the outer layer collagen fiber silk thread and the sericin layer are all made of materials which can be absorbed by human bodies, so that the collagen fiber silk thread is conveniently absorbed by patients.
Drawings
In order to more clearly illustrate the detailed description of the invention or the technical solutions in the prior art, the drawings that are needed in the detailed description of the invention or the prior art will be briefly described below. Throughout the drawings, like elements or portions are generally identified by like reference numerals. In the drawings, elements or portions are not necessarily drawn to scale.
FIG. 1 is a first schematic structural diagram of the present invention;
FIG. 2 is a second schematic structural view of the present invention;
in the figure: 1. inner collagen fiber silk thread 2, outer collagen fiber silk thread 3, the sericin layer.
Detailed Description
The invention is further described below with reference to the accompanying drawings:
the present invention is further illustrated by the following specific examples, which are not intended to limit the scope of the invention, and any modifications, equivalents, improvements, etc. made within the spirit and principle of the present invention should be included in the scope of the present invention.
Examples
As shown in fig. 1-2, the degradable collagen thread includes an inner collagen fiber thread 1, an outer collagen fiber thread 2 and a sericin layer 3, wherein the outer collagen fiber thread 2 is provided with a plurality of outer collagen fiber threads, the plurality of outer collagen fiber threads 2 are parallel to each other and spirally wound on the surface of the inner collagen fiber thread 1 to form an outer layer, and the surface of the outer layer is provided with a sericin layer 3.
In this embodiment, at least eight outer collagen fiber filaments 2 are provided; the adjacent outer collagen fiber silk threads 2 are closely arranged; the inner collagen fiber threads 1 are provided with a plurality of inner collagen fiber threads, and the inner collagen fiber threads 1 are parallel to each other to form a bundle-shaped structure; the diameter of the inner layer collagen fiber silk thread 1 is larger than that of the outer layer collagen fiber silk thread 2; the diameters of the inner layer collagen fiber silk thread 1 and the outer layer collagen fiber silk thread 2 are equal; the thickness of the silk glue layer 3 is 0.1-0.5 mm; the diameters of the inner layer collagen fiber silk threads 1 and the outer layer collagen fiber silk threads 2 are not equal.
The invention also provides a preparation method of the easily degradable collagen thread, wherein a plurality of inner layer collagen fiber silk threads 1 are arranged in parallel to form a bundle-shaped structure, a plurality of outer layer collagen fiber silk threads 2 are wound on the outer side of the bundle-shaped structure, the plurality of outer layer collagen fiber silk threads 2 are parallel to each other and spirally wound on the surface of the inner layer collagen fiber silk threads 1 to form an outer layer, and finally, a silk glue layer 3 is poured on the outer side of the outer layer, so that the fracture of a suture line is reduced; the inner layer collagen fiber silk thread 1, the outer layer collagen fiber silk thread 2 and the sericin layer 3 are made of materials which can be absorbed by human bodies.
The foregoing shows and describes the general principles, essential features, and advantages of the invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (10)
1. An easily degradable collagen line, which is characterized in that: including inlayer collagen fiber silk thread (1), outer collagen fiber silk thread (2) and sericin layer (3), outer collagen fiber silk thread (2) are provided with many, many outer collagen fiber silk thread (2) are parallel to each other and are the heliciform and twine on the surface of inlayer collagen fiber silk thread (1), form the outer layer, outer surface has sericin layer (3).
2. The degradable collagen line according to claim 1, wherein: the outer collagen fiber silk threads (2) are at least provided with eight.
3. The degradable collagen line according to claim 2, wherein: the adjacent outer collagen fiber silk threads (2) are closely arranged.
4. The degradable collagen line according to claim 3, wherein: the inner collagen fiber threads (1) are provided with a plurality of inner collagen fiber threads, and the inner collagen fiber threads (1) are parallel to each other to form a bundle-shaped structure.
5. The degradable collagen line according to claim 4, wherein: the diameter of the inner layer collagen fiber silk thread (1) is larger than that of the outer layer collagen fiber silk thread (2).
6. The degradable collagen line according to claim 5, wherein: the inner layer collagen fiber silk thread (1) and the outer layer collagen fiber silk thread (2) have the same diameter.
7. The degradable collagen line according to claim 6, wherein: the thickness of the silk glue layer (3) is 0.1-0.5 mm.
8. The degradable collagen line according to claim 7, wherein: the diameters of the inner layer collagen fiber silk thread (1) and the outer layer collagen fiber silk thread (2) are not equal.
9. A preparation method of an easily degradable collagen line is characterized by comprising the following steps: many inlayer collagen fiber silk threads (1) parallel arrangement form and restraint the column structure, and many outer collagen fiber silk threads (2) of outside winding that should restraint the column structure again, and many outer collagen fiber silk threads (2) are parallel to each other and are the heliciform and twine in the surface of inlayer collagen fiber silk thread (1), form the skin, pour a layer of silk glue film (3) in the outer outside at last to reduce the fracture of stylolite.
10. The method for preparing a collagen line easy to degrade according to claim 9, wherein: the inner layer collagen fiber silk thread (1), the outer layer collagen fiber silk thread (2) and the sericin layer (3) are made of materials which can be absorbed by human bodies.
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CN202011428881.9A CN112402686A (en) | 2020-12-09 | 2020-12-09 | Easily degradable collagen line and preparation method thereof |
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CN202011428881.9A CN112402686A (en) | 2020-12-09 | 2020-12-09 | Easily degradable collagen line and preparation method thereof |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN115089757A (en) * | 2022-07-28 | 2022-09-23 | 单县华宇缝合制品有限公司 | Processing method of self-degradation type suture line |
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JP2004321484A (en) * | 2003-04-24 | 2004-11-18 | Sangaku Renkei Kiko Kyushu:Kk | Medical high molecular nano-micro fiber |
CN102257192A (en) * | 2008-10-20 | 2011-11-23 | 独立行政法人农业生物资源研究所 | Method for spinning silk from cocoon of silkworm expressing foreign gene, and product produced by employing the method |
CN104135949A (en) * | 2012-03-01 | 2014-11-05 | 新特斯有限责任公司 | Surgical suture with soft core |
CN105770978A (en) * | 2016-03-21 | 2016-07-20 | 江苏广达医材集团有限公司 | Biodegradable medical abdominal surgical suture material |
CN207356099U (en) * | 2017-01-12 | 2018-05-15 | 广州瑞信化妆品有限公司 | A kind of absorbable suture of wound suture |
US20200046872A1 (en) * | 2018-08-08 | 2020-02-13 | MilMedx Group, Inc. | Collagen constructs and methods of making the same |
CN211272628U (en) * | 2019-11-08 | 2020-08-18 | 南昌市天保兴成医疗器械有限公司 | Suture line capable of absorbing collagen |
-
2020
- 2020-12-09 CN CN202011428881.9A patent/CN112402686A/en active Pending
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2004321484A (en) * | 2003-04-24 | 2004-11-18 | Sangaku Renkei Kiko Kyushu:Kk | Medical high molecular nano-micro fiber |
CN102257192A (en) * | 2008-10-20 | 2011-11-23 | 独立行政法人农业生物资源研究所 | Method for spinning silk from cocoon of silkworm expressing foreign gene, and product produced by employing the method |
CN104135949A (en) * | 2012-03-01 | 2014-11-05 | 新特斯有限责任公司 | Surgical suture with soft core |
CN105770978A (en) * | 2016-03-21 | 2016-07-20 | 江苏广达医材集团有限公司 | Biodegradable medical abdominal surgical suture material |
CN207356099U (en) * | 2017-01-12 | 2018-05-15 | 广州瑞信化妆品有限公司 | A kind of absorbable suture of wound suture |
US20200046872A1 (en) * | 2018-08-08 | 2020-02-13 | MilMedx Group, Inc. | Collagen constructs and methods of making the same |
CN211272628U (en) * | 2019-11-08 | 2020-08-18 | 南昌市天保兴成医疗器械有限公司 | Suture line capable of absorbing collagen |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN115089757A (en) * | 2022-07-28 | 2022-09-23 | 单县华宇缝合制品有限公司 | Processing method of self-degradation type suture line |
CN115089757B (en) * | 2022-07-28 | 2024-04-12 | 单县华宇缝合制品有限公司 | Processing technology method of self-degradable suture line |
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