CN110947025A

CN110947025A - Absorbable medical suture line with good degradation resistance and compatibility and preparation method thereof

Info

Publication number: CN110947025A
Application number: CN201911311082.0A
Authority: CN
Inventors: 吴德成; 朱坤福; 薛飞
Original assignee: Shandong Zhushi Pharmaceutical Group Co ltd
Current assignee: Shandong Zhushi Pharmaceutical Group Co ltd
Priority date: 2019-12-18
Filing date: 2019-12-18
Publication date: 2020-04-03

Abstract

The invention relates to an absorbable medical suture line with good degradation resistance and good compatibility, wherein the suture line wire is a multi-strand braided line and comprises a core yarn, a braided layer and an antibacterial coating layer, the braided layer is arranged on the outer side of the core yarn, the antibacterial coating layer is arranged on the outer side of the braided layer, and the core yarn comprises the following raw materials in parts by weight: polyglycolide, carbon fiber, pure natural collagen; the woven layer comprises a second suture line, and the second suture line comprises the following raw materials in parts by weight: polyglycolide, carbon fiber, pure natural collagen, mannitol and vanillin. The invention also provides a preparation method of the absorbable medical suture line with good degradation resistance and compatibility. The invention has the following beneficial effects: is suitable for industrial production and has wide application prospect; the tensile strength is high, and the steel wire is not easy to break; has good biocompatibility and degradability, and can be absorbed after being used for suturing without stitches being removed.

Description

Absorbable medical suture line with good degradation resistance and compatibility and preparation method thereof

Technical Field

The invention relates to an absorbable medical suture line with good degradation resistance and compatibility and a preparation method thereof, belonging to the technical field of preparation of medical suture lines.

Background

The medical suture is a special medical suture used for ligation hemostasis, suture hemostasis and tissue suture in surgical operations, and is divided into absorbable suture and non-absorbable suture. The development of sutures is divided into two stages: in the first stage and the natural material stage, tendon, flax, hair leather, cotton thread, leather, etc. are used as suture thread. In the second stage, the artificial material stage, alternative materials such as nylon and silk threads, which are synthetic polymer materials with high physical properties, have been developed and widely used, in which silk threads are surgical sutures that have been used for the longest time, but these materials are not decomposable and physiologically compatible in the human body, and therefore should be removed by additional surgery after a predetermined time has passed after surgery, and thus, there is inconvenience in use and thus, use is limited.

Disclosure of Invention

According to the defects in the prior art, the technical problems to be solved by the invention are as follows: in order to solve one of the problems, an absorbable medical suture line with good degradation resistance and compatibility and a preparation method thereof are provided.

An absorbable medical suture line with good degradation resistance and compatibility is characterized in that: the stylolite wire rod is stranded braided wire, including core yarn, weaving layer and antibiotic coating, the weaving layer locate the core yarn outside, the weaving layer outside is located to the antibiotic coating, the core yarn includes stylolite one's raw materials includes according to part by weight: 50-70 parts of polyglycolide, 15-35 parts of carbon fiber and 5-15 parts of pure natural collagen; the woven layer comprises a second suture line, and the second suture line comprises the following raw materials in parts by weight: 50-70 parts of polyglycolide, 15-35 parts of carbon fiber, 5-15 parts of pure natural collagen, 2-4 parts of mannitol and 3-5 parts of vanillin.

The invention also provides a preparation method of the absorbable medical suture line with good degradation resistance and compatibility, which is characterized by comprising the following steps: the method comprises the following steps:

s1: making a core yarn:

s11, weighing the raw materials, chitosan and hyaluronic acid according to the requirement, dissolving the chitosan in an acetic acid solution, and stirring to obtain a first mixture;

s12, adding hyaluronic acid into the first mixture, stirring at the speed of 150-200rpm for 5-8min, and defoaming to obtain a coating solution;

s13, coating the suture I with the coating solution, and then drying to obtain core yarn;

s2: manufacturing a woven layer:

s21, weighing the raw materials, chitosan and hyaluronic acid according to the requirement, dissolving the chitosan in an acetic acid solution, and stirring to obtain a first mixture;

s22, adding hyaluronic acid into the first mixture, stirring at the speed of 150-200rpm for 5-8min, and defoaming to obtain a coating solution;

s23, coating the suture II with the coating solution, and then drying to obtain a single strand of the braided layer;

s3: weaving the core yarn obtained in the step one and the single-strand ropes of the woven layer obtained in the step two together:

s31, taking single strands and core yarns of a plurality of woven layers, and connecting the head ends and the tail ends of the core yarns to form an annular guide piece; wherein, the single-stranded rope of the braided layer is arranged into a spiral structure;

s32, connecting the two ends of the core yarn to form an annular guide piece, and winding the single-strand rope of the woven layer on the annular guide piece to arrange the annular guide piece at the central position of the spiral structure of the single-strand rope of the woven layer;

s33, arranging single strands of the braided layers to be wound outside the annular guide piece and tightly attached to the annular guide piece to obtain the braided layers;

s4: manufacturing an antibacterial coating layer:

and (4) taking the coating solution prepared in the step two, coating the core yarn and woven layer combined body obtained in the step three with the coating solution, and then drying to obtain the medical operation suture line with the antibacterial coating layer.

Preferably, the braided layer is a winding structure formed by six single strands of ropes, namely a first strand rope, a second strand rope, a third strand rope, a fourth strand rope, a fifth strand rope and a sixth strand rope.

Preferably, the first strand of rope is helically wound around the core yarn; the second strand is spirally wound on the core yarn and tightly presses the first strand; the third strand is spirally wound on the core yarn and tightly presses the second strand; the fourth strand is spirally wound on the core yarn and tightly presses the third strand; the fifth strand is spirally wound on the core yarn and tightly presses the fourth strand; the sixth strand is helically wound around the core yarn and compresses the fifth strand.

Preferably, the suture is an absorbent suture.

Preferably, the steps S11 and S12 are performed in a batching apparatus, the batching apparatus is a batching tank, and includes a batching tank body, the upper portion of the batching tank body is provided with a plurality of feeding ports for feeding, different types of materials can be fed into the batching tank body for mixing, a mixing motor is fixed at the top of the batching tank body, an output shaft of the mixing motor is fixedly connected with a mixing shaft, the mixing shaft extends into the batching tank body, a stirring paddle for stirring the materials is fixed at the bottom of the mixing shaft, the bottom of the batching tank body is of a hemispherical structure, a discharging device for discharging is fixed at the lowest point position of the bottom of the batching tank body, the discharging device is a liquid pump, a discharging pipe is connected to a discharging port of the discharging device, and a support column foot is further arranged at the bottom of the batching tank body; the hybrid motor is a variable frequency motor and is connected to 380V industrial electricity.

Preferably, the coating solution is obtained by adding the following raw materials into a stirring kettle according to the mass percentage and uniformly stirring the raw materials by a batching tank: 10-30 parts of chitosan: 0.6-0.9 of hyaluronic acid; the concentration of the acetic acid solution is 0.6-5.0 mmol/L.

Preferably, the coating solution is obtained by adding the following raw materials into a stirring kettle according to the mass percentage and uniformly stirring the raw materials by a batching tank: and (3) chitosan 26: 0.8 of hyaluronic acid; the concentration of the acetic acid solution was 3.6 mmol/L.

Preferably, the drying is carried out in the drying cabinet, the drying cabinet includes the outer container, the outer container embeds there is the inner box, the inner box roof is detachable construction, be provided with the gas vent on the roof, the clearance has between outer container and the inner box, this clearance is annular inner chamber, install the heater strip in the cavity, annular inner chamber's top has annular last shrouding, go up and install the fan on the shrouding, the air intake and the external world of fan are linked together, the air outlet and the annular inner chamber of fan are linked together, the thing board has been placed to the inside of inner box, the air intake has been seted up to the bottom of inner box, inner chamber and the annular inner chamber with the inner.

The degradable and absorbable medical suture is prepared by the method, the suture wire is a multi-strand braided wire and comprises a core yarn, a braided layer and an antibacterial coating layer, the braided layer is arranged on the outer side of the core yarn, and the antibacterial coating layer is arranged on the outer side of the braided layer.

Preferably, the suture thread is 35 cm in length, circular in cross-section and 5 mm in diameter.

Compared with the prior art, the invention has the following beneficial effects:

the preparation method of the absorbable medical suture line with good degradation resistance and compatibility, disclosed by the invention, has the advantages of simple process, convenience in operation, low cost and low energy consumption, is suitable for industrial production, and has a great application prospect;

the absorbable medical suture line with good degradation resistance and compatibility can effectively improve the mechanical property and the drug-loading property of the fiber and the finally prepared medical suture line, and has high tensile strength and is not easy to break;

the absorbable medical suture line with good degradation resistance and compatibility can maintain the appearance and mechanical physical properties of the suture line, can improve the biocompatibility and various physiological activity effects in a human body, has good biocompatibility and degradability, can be absorbed after being used for suturing, and does not need to be removed from the suture line.

Drawings

In order to more clearly illustrate the detailed description of the invention or the technical solutions in the prior art, the drawings that are needed in the detailed description of the invention or the prior art will be briefly described below. Throughout the drawings, like elements or portions are generally identified by like reference numerals. In the drawings, elements or portions are not necessarily drawn to scale.

FIG. 1 is a cross-sectional view of the present invention;

FIG. 2 is a process diagram of the present invention;

FIG. 3 is a block diagram of the dispensing tank;

fig. 4 is a structural view of the drying box.

In the figure: 1. core yarn 2, weaving layer 3, antibiotic coating 4, batching jar body 5, pan feeding mouth 6, hybrid motor 7, mixing shaft 8, stirring rake 9, discharging device 10, discharging pipe 11, support column base 12, outer container 13, inner box 14, heater strip 15, last shrouding 16, fan 17, air intake 18, gas vent 19, put the thing board.

Detailed Description

The invention is further described below with reference to the accompanying drawings:

the present invention is further illustrated by the following specific examples, which are not intended to limit the scope of the invention, and any modifications, equivalents, improvements, etc. made within the spirit and principle of the present invention should be included in the scope of the present invention.

Example one

As shown in fig. 1-4, an absorbable medical suture with good degradation resistance and compatibility is characterized in that: the stylolite wire rod is stranded braided wire, including core yarn 1, weaving layer 2 and antibiotic coating 3, weaving layer 2 locate the 1 outside of core yarn, antibiotic coating 3 locates the 2 outsides of weaving layer, core yarn 1 includes stylolite one, stylolite one's raw materials include according to parts by weight: 50-70 parts of polyglycolide, 15-35 parts of carbon fiber and 5-15 parts of pure natural collagen; the woven layer 2 comprises a second suture line, and the second suture line comprises the following raw materials in parts by weight: 50-70 parts of polyglycolide, 15-35 parts of carbon fiber, 5-15 parts of pure natural collagen, 2-4 parts of mannitol and 3-5 parts of vanillin.

Example two

A preparation method of an absorbable medical suture line with good degradation resistance and compatibility comprises the following steps:

s1: production of core yarn 1: s11, weighing the raw materials, chitosan and hyaluronic acid according to the requirement, dissolving the chitosan in an acetic acid solution, and stirring to obtain a first mixture; s12, adding hyaluronic acid into the first mixture, stirring at the speed of 150-200rpm for 5-8min, and defoaming to obtain a coating solution; s13, coating the suture I with the coating solution, and then drying to obtain a core yarn 1;

s2: manufacturing of the braided layer 2: s21, weighing the raw materials, chitosan and hyaluronic acid according to the requirement, dissolving the chitosan in an acetic acid solution, and stirring to obtain a first mixture; s22, adding hyaluronic acid into the first mixture, stirring at the speed of 150-200rpm for 5-8min, and defoaming to obtain a coating solution; s23, coating the suture II with the coating solution, and then drying to obtain a single strand of the braided layer 2;

s3: and (3) weaving the core yarn 1 obtained in the step one and the single-strand ropes of the weaving layer 2 obtained in the step two together: s31, taking single strands of the plurality of weaving layers 2 and the core yarns 1, and connecting the head ends and the tail ends of the core yarns 1 to form an annular guide piece; wherein, the single-stranded rope of the braided layer 2 is arranged into a spiral structure; s32, connecting the two ends of the core yarn 1 to form an annular guide member, and winding the single-strand rope of the woven layer 2 on the annular guide member to arrange the annular guide member at the central position of the spiral structure of the single-strand rope of the woven layer 2; s33, arranging single-stranded ropes of the braided layers 2 to be wound outside the annular guide piece and tightly attached to the annular guide piece to obtain the braided layers 2;

s4: and (3) manufacturing an antibacterial coating layer: and (3) taking the coating solution prepared in the step two, coating the combined body of the core yarn 1 and the weaving layer 2 obtained in the step three with the coating solution, and then drying to obtain the medical operation suture with the antibacterial coating layer 3.

In this embodiment, the braided layer 2 is a winding structure formed by six single strands of ropes, which are a first strand of rope, a second strand of rope, a third strand of rope, a fourth strand of rope, a fifth strand of rope, and a sixth strand of rope; the first strand of rope is spirally wound on the core yarn 1; the second strand is spirally wound on the core yarn 1 and tightly presses the first strand; the third strand is spirally wound on the core yarn 1 and tightly presses the second strand; the fourth strand is spirally wound on the core yarn 1 and tightly presses the third strand; the fifth strand is spirally wound on the core yarn 1 and tightly pressed against the fourth strand; the sixth strand is spirally wound on the core yarn 1 and tightly presses the fifth strand; the suture is an absorbent suture; steps S11 and S12 are carried out in a batching device, the batching device is a batching tank and comprises a batching tank body 4, the upper part of the batching tank body 4 is provided with a plurality of feeding ports 5 for feeding, different types of materials can be fed into the batching tank body 4 for mixing and batching, a mixing motor 6 is fixed at the top of the batching tank body 4, an output shaft of the mixing motor 6 is fixedly connected with a mixing shaft 7, the mixing shaft 7 extends into the batching tank body 4, a stirring paddle 8 for stirring the materials is fixed at the bottom of the mixing shaft 7, the bottom of the batching tank body 4 is of a hemispherical structure, a discharging device 9 for discharging is fixed at the lowest point position of the bottom of the batching tank body 4, the discharging device 9 is a liquid pump, a discharging pipe 10 is connected to a discharging port of the discharging device 9, and a supporting column foot 11 is further arranged at the bottom of the batching tank body 4; the hybrid motor 6 is a variable frequency motor, and the hybrid motor 6 is connected to 380V industrial electricity; the coating solution is prepared by adding the following raw materials into a stirring kettle according to the mass percentage and uniformly stirring the raw materials by a batching tank: 10-30 parts of chitosan: 0.6-0.9 of hyaluronic acid; the concentration of the acetic acid solution is 0.6-5.0 mmol/L; the coating solution is prepared by adding the following raw materials into a stirring kettle according to the mass percentage and uniformly stirring the raw materials by a batching tank: and (3) chitosan 26: 0.8 of hyaluronic acid; the concentration of the acetic acid solution is 3.6 mmol/L; the drying is gone on in the drying cabinet, the drying cabinet includes outer container 12, outer container 12 embeds there is inner box 13, inner box 13 roof is detachable construction, be provided with gas vent 18 on the roof, the clearance has between outer container 12 and the inner box 13, this clearance is annular inner chamber, install heater strip 14 in the cavity, annular inner chamber's top has annular last shrouding 15, go up and install fan 16 on the shrouding 15, fan 16's air intake is linked together with the external world, fan 16's air outlet is linked together with annular inner chamber, thing board 19 has been placed to inner box 13's inside, air intake 17 has been seted up to inner box 13's bottom, inner chamber and annular inner chamber through air intake 17 with inner box 13 are linked together.

EXAMPLE III

The suture I comprises the following raw materials in parts by weight: 65 parts of polyglycolide, 26 parts of carbon fiber and 14 parts of pure natural collagen;

the second suture line comprises the following raw materials in parts by weight: 60 parts of polyglycolide, 30 parts of carbon fiber, 14 parts of pure natural collagen, 3 parts of mannitol and 4 parts of vanillin.

The foregoing shows and describes the general principles, essential features, and advantages of the invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.

Claims

1. An absorbable medical suture line with good degradation resistance and compatibility is characterized in that: the stylolite wire rod is stranded braided wire, including core yarn (1), weaving layer (2) and antibiotic coating (3), weaving layer (2) locate core yarn (1) outside, weaving layer (2) outside is located in antibiotic coating (3), core yarn (1) includes stylolite one, stylolite one's raw materials include according to the part by weight: 50-70 parts of polyglycolide, 15-35 parts of carbon fiber and 5-15 parts of pure natural collagen; the woven layer (2) comprises a second suture line, and the second suture line comprises the following raw materials in parts by weight: 50-70 parts of polyglycolide, 15-35 parts of carbon fiber, 5-15 parts of pure natural collagen, 2-4 parts of mannitol and 3-5 parts of vanillin.

2. A preparation method of absorbable medical suture with good degradation resistance and compatibility is characterized in that: the method comprises the following steps:

s1: production of the core yarn (1):

s13, coating the suture I with the coating solution, and then drying to obtain a core yarn (1);

s2: manufacturing a braided layer (2):

s23, coating the suture II with the coating solution, and then drying to obtain a single strand of the braided layer (2);

s3: weaving the core yarn (1) obtained in the step one and the single-strand rope of the weaving layer (2) obtained in the step two together:

s31, taking single strands of a plurality of weaving layers (2) and core yarns (1), and connecting the head ends and the tail ends of the core yarns (1) to form an annular guide piece; wherein, the single-stranded rope of the braided layer (2) is arranged into a spiral structure;

s32, connecting the head end and the tail end of the core yarn (1) to form an annular guide piece, and winding the single-strand rope of the woven layer (2) on the annular guide piece to arrange the annular guide piece at the central position of the spiral structure of the single-strand rope of the woven layer (2);

s33, arranging single strands of the plurality of braided layers (2) to be wound outside the annular guide piece and tightly attached to the annular guide piece to obtain the braided layers (2);

s4: manufacturing an antibacterial coating layer (3):

taking the coating solution prepared in the step two, coating the combination of the core yarn (1) and the weaving layer (2) obtained in the step three with the coating solution, and then drying to obtain the medical operation suture with the antibacterial coating layer (3);

the suture I comprises the following raw materials in parts by weight: 50-70 parts of polyglycolide, 15-35 parts of carbon fiber and 5-15 parts of pure natural collagen;

the second suture line comprises the following raw materials in parts by weight: 50-70 parts of polyglycolide, 15-35 parts of carbon fiber, 5-15 parts of pure natural collagen, 2-4 parts of mannitol and 3-5 parts of vanillin.

3. The method for preparing the absorbable medical suture line with good degradation resistance and compatibility according to claim 2, which is characterized in that: the first strand of rope is spirally wound on the core yarn (1); the second strand is spirally wound on the core yarn (1) and tightly presses the first strand; the third strand is spirally wound on the core yarn (1) and tightly presses the second strand; the fourth strand is spirally wound on the core yarn (1) and tightly presses the third strand; the fifth strand is spirally wound on the core yarn (1) and tightly presses the fourth strand; the sixth strand is spirally wound around the core yarn (1) and compresses the fifth strand.

4. The method for preparing the absorbable medical suture line with good degradation resistance and compatibility according to claim 4, which is characterized in that: the suture is an absorbent suture.

5. The method for preparing the absorbable medical suture line with good degradation resistance and compatibility according to claim 2, which is characterized in that: the suture I comprises the following raw materials in parts by weight: 65 parts of polyglycolide, 26 parts of carbon fiber and 14 parts of pure natural collagen; the second suture line comprises the following raw materials in parts by weight: 60 parts of polyglycolide, 30 parts of carbon fiber, 14 parts of pure natural collagen, 3 parts of mannitol and 4 parts of vanillin.