CN103816564A - Long-acting controlled-release antibacterial real silk woven type surgical suture and preparing method thereof - Google Patents
Long-acting controlled-release antibacterial real silk woven type surgical suture and preparing method thereof Download PDFInfo
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- CN103816564A CN103816564A CN201410078374.5A CN201410078374A CN103816564A CN 103816564 A CN103816564 A CN 103816564A CN 201410078374 A CN201410078374 A CN 201410078374A CN 103816564 A CN103816564 A CN 103816564A
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Abstract
The invention provides a long-acting controlled-release antibacterial real silk woven type surgical suture and a preparing method thereof. The long-acting controlled-release antibacterial real silk woven type surgical suture is characterized by including heart yarn and weaving yarn that are woven, wherein the surfaces of the heart yarn and the weaving yarn are coated with antibacterial coatings; the antibacterial coatings contain macromolecular absorbing material and quinolone antibacterial drugs. As the weaving yarn contains antibacterial drugs, the long-acting controlled-release antibacterial real silk woven type surgical suture has the functions of sterilization and bacteriostasis; as the antibacterial drugs are uniformly dispersed in the macromolecular absorbing material, can be slowly released along with the swelling and degradation of the macromolecular absorbing material, so that the long-acting controlled-release antibacterial real silk woven type surgical suture has the long-acting controlled-release antibacterial effect.
Description
Technical field
The invention discloses New-type long-acting slow release anti-bacteria real silk Weaving type suture and preparation method thereof.
Background technology
Real silk braided suture is cheap, harmless, and the aminoacid that can provide needed by human body to want, is therefore to use suture material comparatively widely in modern surgery operation, particularly more in aspect application such as epidermis stitching, little vascular ligation, hollow organ coincide.Current real silk stitching thread adopts the structure of Weaving type, on ingot formula braider, weave and make, drive the spool motion being placed on spindle by spindle, all spools are divided into two groups, two groups of spool directions of motion are contrary, interlaced in the time that spindle meets, the yarn on the spool of rightabout motion also can be interlaced, thereby form the structure of weaving.Because the sth. made by twisting of strand is wherein to being positive and negative two-way, can keep balance, therefore while being subject to external force, do not change with internal stress, therefore in woven structure, the mutual obvolvent of yarn is tightr, bar is dry more even, can not produce kink phenomenon, soft, bending stiffness is low, knotting posterior tubercle is little, ties a knot safe.
In surgical operation, also there is certain shortcoming in real silk braided suture.On the one hand, fibroin belongs to protein fibre, easily becomes the nutriment source of growth of microorganism and breeding, to the less stable of microorganism; On the other hand, woven structure makes to exist between knitting yarn gap, and when sewing up easy pollution or infected wound, antibacterial is easily concealed in the gap on stitching thread surface, and then the risk that increases postoperative surgical site and infect (SSIs).Therefore, exploitation anti-bacteria real silk braided suture is significant for reducing surgical site infection (SSIs).
At present more existing researchs are devoted to develop antibacterial stitching thread and have been obtained corresponding achievement, for example: the tall antibacterial stitching thread of common vetch of (1) Johson & Johnson exploitation, it is the method endowing antibacterial energy that adopts coating on PGLA910 stitching thread, in coating, add broad spectrum antimicrobicide---IRGACARE MP* (one of triclosan that purity is the highest, Triclosan), this stitching thread is nontoxic, nonirritant, can not have a negative impact to wound healing process, there is the antibacterial effect of long-acting slow-release, but because price is relatively high, therefore still there is certain difficulty in the market extensive use of China's stitching thread, (2) the antibacterial stitching thread of silver ion, as Chinese patent (publication number CN1940168A, Granted publication CN201091693Y and publication number CN102726448A), that stitching thread is flooded in Ag-containing solution, spraying, the methods such as coating make to be attached with silver element on stitching thread and have antibiotic property, but on the one hand, its operation is comparatively complicated, because silver ion antimicrobial agent is in preparation process, easily there is oxidation reaction and anti-microbial property is declined, on the other hand, in operating process, may relate to the chemical reagent such as ammonia, cause environmental pollution, be unfavorable for operator's health, (3) Chinese herbal antibacterial stitching thread, as Chinese patent (publication number CN101584878A and publication number CN101584595A), utilize the antibiotic property of Chinese medicine, there is antibiotic property with Chinese medicine dipping or coating stitching thread, but the antimicrobial sustained-release effect of this technique still has some deficits.(4) Chinese patent (CN103215779A), on the real silk stitching thread of knitting forming, has prepared antibacterial stitching thread by the method for degradable high polymer and antibacterials mixed coating.Its shortcoming is: adopt the first technique of the rear coating of braiding, antimicrobial coating is to be distributed in the outside of litzendraht wire rather than the outside of heart yarn and knitting yarn, like this, easily cause antimicrobial coating material at stitching thread braiding intertwined point place possibility excess accumulation, antibacterial is poor in the uniformity of stitching thread surface distributed, affects antibacterial effect.
Summary of the invention
The object of the present invention is to provide a kind of real silk Weaving type stitching thread with antibacterial effect and preparation method thereof, its anti-microbial property persistent period and wound healing speed match, to reach the object that prevents wound infection.
To achieve these goals, the invention provides a kind of long-acting slow-release anti-bacteria real silk Weaving type suture, it is characterized in that, comprise the heart yarn and the knitting yarn that are woven together, wherein, described heart yarn and the surface of knitting yarn are all coated with antimicrobial coating.
Preferably, in described antimicrobial coating, contain macromolecule absorbable material and carbostyril family antibacterial drugs.
More preferably, described carbostyril family antibacterial drugs is levofloxacin, levofloxacin hydrochloride or levofloxacin lactate.
More preferably, described macromolecule absorbable material is polycaprolactone, chitosan or polylactic acid.
More preferably, the molecular weight of described polycaprolactone is 5～180,000, and the molecular weight of chitosan is 3～200,000, and the molecular weight of polylactic acid is 5～120,000.
The present invention also provides the preparation method of above-mentioned long-acting slow-release anti-bacteria real silk Weaving type suture, it is characterized in that, concrete steps comprise:
The first step: macromolecule absorbable material is dissolved in and obtains macromolecule absorbable material solution in corresponding solvent, under normal temperature environment, use 2～8 hours extremely complete mix homogeneously of magnetic stirrer, add the carbostyril family antibacterial drugs powder grinding, in gained mixture, the concentration of carbostyril family antibacterial drugs is 1000～5000 μ g/ml, under room temperature state, with magnetic stirrer mix homogeneously extremely completely, obtain coating material;
Second step: coating material is placed in to plater, and the heart yarn to doubling twisting and knitting yarn carry out 1～3 antimicrobial coating processing respectively to use plater;
The 3rd step: adopt the medical special braider of 12 ingot or the medical special braider of 16 ingots to be woven together heart yarn after treatment antimicrobial coating and knitting yarn, obtain long-acting slow-release anti-bacteria real silk Weaving type suture.
Preferably, when described macromolecule absorbable material is polycaprolactone, the concentration of macromolecule absorbable material solution is 5%～10%, when described macromolecule absorbable material is chitosan, the concentration of macromolecule absorbable material solution is 2%～5%, when described macromolecule absorbable material is polylactic acid, the concentration of macromolecule absorbable material solution is 2%～7%.
Preferably, plater in described second step is made up of coating area and arid region, in described coating area, be at least provided with maceration tank, the first dip roll, first heater, the first pressure roll, the first deflector roll, immersion tank, the second dip roll, secondary heating mechanism and the second pressure roll, in described arid region, be at least provided with the second deflector roll, the 3rd deflector roll and cylinder, the first dip roll and the second dip roll are located at respectively in maceration tank and immersion tank, maceration tank and immersion tank are located at respectively on first heater and secondary heating mechanism, the first pressure roll is made up of the first rubber rollers and the first stainless steel rider of being located under it, the first pressure roll is located between maceration tank and immersion tank, the first deflector roll is located between the first pressure roll and maceration tank, the second pressure roll is made up of the second rubber rollers and the second stainless steel rider of being located under it, the second pressure roll is located between immersion tank and cylinder, the second deflector roll and the 3rd deflector roll are located between the second pressure roll and cylinder.
More preferably, the length of described arid region B is 4～6 meters.
More preferably, in described second step, coating material is placed in to maceration tank and the immersion tank of plater, the process of each antimicrobial coating processing is: by first heater and secondary heating mechanism, the coating material in maceration tank and immersion tank is maintained to 45 ℃ of constant temperature respectively, the heart yarn of doubling twisting or knitting yarn are immersed in the maceration tank in coating area, heart yarn or knitting yarn are successively by the first dip roll and the first pressure roll, be passed to immersion tank through the first deflector roll, heart yarn or knitting yarn are successively by the second dip roll and the second pressure roll, enter again and in arid region, carry out normal temperature drying, heart yarn or knitting yarn are successively through the second deflector roll and the 3rd deflector roll, finally be wound on cylinder.
More preferably, the second described deflector roll and the 3rd deflector roll rotate with the speed of 40 circles that slowly run per minute.
Compared with prior art, the invention has the beneficial effects as follows:
A) on knitting yarn of the present invention, contain antibacterials, therefore there is sterilization and antibacterial effect; Because antibacterials are dispersed in macromolecule absorbable material, along with the swelling of macromolecule absorbable material and degraded, antibacterials slowly discharge, and therefore have the antibacterial effect of long-acting slow-release.Adopt respectively heart yarn and the knitting yarn of coating doubling twisting before and after treatment to prepare braided suture, all adopt antibacterial standard GB/T20944.1-2007 agar plate diffusion method to carry out antibacterial contrast test to Gram-positive staphylococcus aureus (S.aureus) and Gram-negative escherichia coli (E.coli) two kinds of stitching thread after braiding, can kill antibacterial through the real silk braided suture of antimicrobial treatment.
B) anti-bacteria real silk braided suture of the present invention has the antibacterial effect of long-acting slow-release, and according to different coating formulas, Durability of antimicrobial effect can regulate and control between 3～6 days, was applicable to the healing of different tissues wound.Especially postoperative first three days is the high-risk period of surgical site infection normally, and stitching thread during this period, as having certain antibiotic property, can effectively prevent surgical site infection.
c)。The present invention is first to the processing of knitting yarn antimicrobial coating, and then the knitting yarn of coating is woven into antibacterial stitching thread.Like this, reduce the risk of antimicrobial coating material at stitching thread braiding intertwined point place possibility excess accumulation, antibacterial is improved in the uniformity of stitching thread surface distributed.
D) anti-bacteria real silk braided suture of the present invention adopts national pharmaceuticals industry standard YY0167-2005 nonabsorbable surgical suture test physical and mechanical properties, after processing, stitching thread smooth surface is without filoplume, bar is evenly dry, and close structure, the requirement of tensile strength conformance with standard, can keep the pliable and tough advantage of real silk material and the good soft feel of braiding structure, not affect operation and use, the specification of suture and wire range, the equal conformance with standard regulation of tensile strength.
E) the present invention is investigating on the basis of a large amount of medical antibacterial agent of contrast, select quinolones synthetic antimicrobial drug, levofloxacin is its representation type of new generation, there are the products such as levofloxacin, levofloxacin hydrochloride, levofloxacin lactate, as the sutural representative antibacterial of real silk of the present invention.Levofloxacin Main Function mechanism is by the activity of anti-bacteria DNA gyrase, stops the synthetic of DNA of bacteria and copies and cause antibacterial death.The minimal inhibitory concentration (MIC) of levofloxacin is suitable with minimal bactericidal concentration (MBC), and it act as bactericidal properties.Levofloxacin antibacterial action is strong, and has a broad antifungal spectrum all has stronger bactericidal action to the gram positive bacteria including anaerobe and gram-negative bacteria, and the atypia such as mycoplasma pneumoniae, chlamydia pathogen is also had to stronger antibacterial activity.Its pharmacokinetic shows, levofloxacin has the features such as tissue distribution is wide, bioavailability is high, effect is lasting, toxic and side effects is few.
Accompanying drawing explanation
Fig. 1 is long-acting slow-release anti-bacteria real silk Weaving type suture structural representation.
Fig. 2 is plater structural representation.
The specific embodiment
Below in conjunction with embodiment, the present invention is further illustrated, but be not limited to this.The molecular weight of the macromolecule absorbable material described in the present invention is weight average molecular weight.
Embodiment 1:
As shown in Figure 2, for plater structural representation, described plater is made up of coating area A and arid region B, in described coating area A, be at least provided with maceration tank 4, the first dip roll 5, first heater 6, the first pressure roll, the first deflector roll 9, immersion tank 10, the second dip roll 11, secondary heating mechanism 12 and the second pressure roll, in described arid region B, be at least provided with the second deflector roll 15, the 3rd deflector roll 16 and cylinder 17, the first dip roll 5 and the second dip roll 11 are located at respectively in maceration tank 4 and immersion tank 10, maceration tank 4 and immersion tank 10 are located at respectively on first heater 6 and secondary heating mechanism 12, the first pressure roll is made up of the first rubber rollers 7 and the first stainless steel rider 8 of being located under it, the first pressure roll is located between maceration tank 4 and immersion tank 10, the first deflector roll 9 is located between the first pressure roll and maceration tank 4, the second pressure roll is made up of the second rubber rollers 13 and the second stainless steel rider 14 of being located under it, the second pressure roll is located between immersion tank 10 and cylinder 17, the second deflector roll 15 and the 3rd deflector roll 16 are located between the second pressure roll and cylinder 17.The length of described arid region B is 4 meters.
As shown in Figure 1, for long-acting slow-release anti-bacteria real silk Weaving type suture structural representation, described long-acting slow-release anti-bacteria real silk Weaving type suture by heart yarn 1 and knitting yarn 2 form, heart yarn 1 and knitting yarn 2 are woven together, described heart yarn 1 and the surface of knitting yarn 2 are all coated with antimicrobial coating 3, contain molecular weight and be 180,000 polycaprolactone and levofloxacin medicine in described antimicrobial coating 3.Its preparation method is:
A) preparation of coating material
The polycaprolactone that is 180,000 by molecular weight is dissolved in glacial acetic acid, make mass fraction and be 10% polycaprolactone solution, under normal temperature environment, use 8 hours extremely complete mix homogeneously of magnetic stirrer, get 10ml and mix polycaprolactone solution completely, the levofloxacin drug powder that adds 0.05g to grind completely, in gained mixture, the concentration of levofloxacin medicine is 5000 μ g/ml, uses 3 hours extremely complete mix homogeneously of magnetic stirrer under room temperature state, obtain coating material, stand-by;
B) coating of heart yarn and knitting yarn
Coating material is placed in to maceration tank 4 and the immersion tank 10 of plater, the heart yarn to doubling twisting (2 strands × 4) and knitting yarn (3 strands × 1) carry out 3 antimicrobial coating processing respectively to use plater, the process of each antimicrobial coating processing is: by first heater 6 and secondary heating mechanism 12, the coating material in maceration tank 4 and immersion tank 10 is maintained to 45 ℃ of constant temperature respectively, the heart yarn of doubling twisting or knitting yarn are immersed in the maceration tank 4 in coating area A, heart yarn or knitting yarn are successively by the first dip roll 5 and the first pressure roll, be passed to immersion tank 10 through the first deflector roll 9, heart yarn or knitting yarn are successively by the second dip roll 11 and the second pressure roll, enter again and in the B of arid region, carry out normal temperature drying, heart yarn or knitting yarn are successively through the second deflector roll 15 and the 3rd deflector roll 16, the second described deflector roll 15 and the 3rd deflector roll 16 rotate with the speed of 40 circles that slowly run per minute, finally be wound on cylinder 17.
C) braiding of coated yarn
Adopt the medical special braider of 12 ingot to be woven into 2-0 heart yarn after treatment antimicrobial coating and knitting yarn
#medical real silk stitching thread, is long-acting slow-release anti-bacteria real silk Weaving type suture.
The prepared antibacterial bandwidth of sutural maximum (being the antibacterial bandwidth of the antibacterial first day): is (15.39 ± 0.36) mm to staphylococcus aureus; Be (16.04 ± 0.51) mm to escherichia coli; Durability of antimicrobial effect: is 5 days to staphylococcus aureus; It is 6 days to escherichia coli.The experiment proved that this antibacterial stitching thread has good antibiotic property and Durability of antimicrobial effect.
Embodiment 2:
As shown in Figure 2, for plater structural representation, described plater is made up of coating area A and arid region B, in described coating area A, be at least provided with maceration tank 4, the first dip roll 5, first heater 6, the first pressure roll, the first deflector roll 9, immersion tank 10, the second dip roll 11, secondary heating mechanism 12 and the second pressure roll, in described arid region B, be at least provided with the second deflector roll 15, the 3rd deflector roll 16 and cylinder 17, the first dip roll 5 and the second dip roll 11 are located at respectively in maceration tank 4 and immersion tank 10, maceration tank 4 and immersion tank 10 are located at respectively on first heater 6 and secondary heating mechanism 12, the first pressure roll is made up of the first rubber rollers 7 and the first stainless steel rider 8 of being located under it, the first pressure roll is located between maceration tank 4 and immersion tank 10, the first deflector roll 9 is located between the first pressure roll and maceration tank 4, the second pressure roll is made up of the second rubber rollers 13 and the second stainless steel rider 14 of being located under it, the second pressure roll is located between immersion tank 10 and cylinder 17, the second deflector roll 15 and the 3rd deflector roll 16 are located between the second pressure roll and cylinder 17.The length of described arid region B is 4 meters.
As shown in Figure 1, for long-acting slow-release anti-bacteria real silk Weaving type suture structural representation, described long-acting slow-release anti-bacteria real silk Weaving type suture by heart yarn 1 and knitting yarn 2 form, heart yarn 1 and knitting yarn 2 are woven together, described heart yarn 1 and the surface of knitting yarn 2 are all coated with antimicrobial coating 3, contain molecular weight and be 80,000 polycaprolactone and levofloxacin medicine in described antimicrobial coating 3.Its preparation method is:
A) preparation of coating material
The polycaprolactone that is 80,000 by molecular weight is dissolved in glacial acetic acid, make mass fraction and be 5% polycaprolactone solution, under normal temperature environment, use 4 hours extremely complete mix homogeneously of magnetic stirrer, get 10ml and mix polycaprolactone solution completely, the levofloxacin drug powder that adds 0.03g to grind completely, in gained mixture, the concentration of levofloxacin medicine is 3000 μ g/ml, uses 3 hours extremely complete mix homogeneously of magnetic stirrer under room temperature state, obtain coating material, stand-by;
B) coating of heart yarn and knitting yarn
Coating material is placed in to maceration tank 4 and the immersion tank 10 of plater, use plater respectively the heart yarn to doubling twisting (2 strands × 4) and knitting yarn (3 strands × 1) carry out 1 antimicrobial coating processing, the process of antimicrobial coating processing is identical with embodiment 1 at every turn.
C) braiding of coated yarn
The braiding of coated yarn is identical with embodiment 1.
The prepared antibacterial bandwidth of sutural maximum (being the antibacterial bandwidth of the antibacterial first day): is (11.27 ± 0.58) mm to staphylococcus aureus; Be (11.94 ± 0.31) mm to escherichia coli; Durability of antimicrobial effect: is 3 days to staphylococcus aureus; It is 3 days to escherichia coli.The experiment proved that this antibacterial stitching thread has certain antibiotic property and Durability of antimicrobial effect.
Embodiment 3:
As shown in Figure 2, for plater structural representation, described plater is made up of coating area A and arid region B, in described coating area A, be at least provided with maceration tank 4, the first dip roll 5, first heater 6, the first pressure roll, the first deflector roll 9, immersion tank 10, the second dip roll 11, secondary heating mechanism 12 and the second pressure roll, in described arid region B, be at least provided with the second deflector roll 15, the 3rd deflector roll 16 and cylinder 17, the first dip roll 5 and the second dip roll 11 are located at respectively in maceration tank 4 and immersion tank 10, maceration tank 4 and immersion tank 10 are located at respectively on first heater 6 and secondary heating mechanism 12, the first pressure roll is made up of the first rubber rollers 7 and the first stainless steel rider 8 of being located under it, the first pressure roll is located between maceration tank 4 and immersion tank 10, the first deflector roll 9 is located between the first pressure roll and maceration tank 4, the second pressure roll is made up of the second rubber rollers 13 and the second stainless steel rider 14 of being located under it, the second pressure roll is located between immersion tank 10 and cylinder 17, the second deflector roll 15 and the 3rd deflector roll 16 are located between the second pressure roll and cylinder 17.The length of described arid region B is 4 meters.
As shown in Figure 1, for long-acting slow-release anti-bacteria real silk Weaving type suture structural representation, described long-acting slow-release anti-bacteria real silk Weaving type suture by heart yarn 1 and knitting yarn 2 form, heart yarn 1 and knitting yarn 2 are woven together, described heart yarn 1 and the surface of knitting yarn 2 are all coated with antimicrobial coating 3, contain molecular weight and be 80,000 polycaprolactone and levofloxacin medicine in described antimicrobial coating 3.Its preparation method is:
A) preparation of coating material
The preparation process of coating material is identical with embodiment 2;
B) coating of heart yarn and knitting yarn
Coating material is placed in to maceration tank 4 and the immersion tank 10 of plater, use plater respectively the heart yarn to doubling twisting (3 strands × 6) and knitting yarn (2 strands × 2) carry out 2 antimicrobial coating processing, the process of antimicrobial coating processing is identical with embodiment 1 at every turn.
C) braiding of coated yarn
Adopt the medical special braider of 16 ingot to be woven into 1 heart yarn after treatment antimicrobial coating and knitting yarn
#medical real silk stitching thread.
The prepared antibacterial bandwidth of sutural maximum (being the antibacterial bandwidth of antibacterial first object): is (12.57 ± 0.20) mm to staphylococcus aureus; Be (13.17 ± 0.68) mm to escherichia coli; Durability of antimicrobial effect: is 3 days to staphylococcus aureus; It is 4 days to escherichia coli.The experiment proved that this antibacterial stitching thread has certain antibiotic property and Durability of antimicrobial effect.
Embodiment 4:
As shown in Figure 2, for plater structural representation, described plater is made up of coating area A and arid region B, in described coating area A, be at least provided with maceration tank 4, the first dip roll 5, first heater 6, the first pressure roll, the first deflector roll 9, immersion tank 10, the second dip roll 11, secondary heating mechanism 12 and the second pressure roll, in described arid region B, be at least provided with the second deflector roll 15, the 3rd deflector roll 16 and cylinder 17, the first dip roll 5 and the second dip roll 11 are located at respectively in maceration tank 4 and immersion tank 10, maceration tank 4 and immersion tank 10 are located at respectively on first heater 6 and secondary heating mechanism 12, the first pressure roll is made up of the first rubber rollers 7 and the first stainless steel rider 8 of being located under it, the first pressure roll is located between maceration tank 4 and immersion tank 10, the first deflector roll 9 is located between the first pressure roll and maceration tank 4, the second pressure roll is made up of the second rubber rollers 13 and the second stainless steel rider 14 of being located under it, the second pressure roll is located between immersion tank 10 and cylinder 17, the second deflector roll 15 and the 3rd deflector roll 16 are located between the second pressure roll and cylinder 17.The length of described arid region B is 4 meters.
As shown in Figure 1, for long-acting slow-release anti-bacteria real silk Weaving type suture structural representation, described long-acting slow-release anti-bacteria real silk Weaving type suture by heart yarn 1 and knitting yarn 2 form, heart yarn 1 and knitting yarn 2 are woven together, described heart yarn 1 and the surface of knitting yarn 2 are all coated with antimicrobial coating 3, contain molecular weight and be 100,000 polycaprolactone and levofloxacin medicine in described antimicrobial coating 3.Its preparation method is:
A) preparation of coating material
The polycaprolactone that is 100,000 by molecular weight is dissolved in glacial acetic acid, make mass fraction and be 7.5% polycaprolactone solution, under normal temperature environment, use 6 hours extremely complete mix homogeneously of magnetic stirrer, get 10ml and mix polycaprolactone solution completely, the levofloxacin drug powder that adds 0.05g to grind completely, in gained mixture, the concentration of levofloxacin medicine is 5000 μ g/ml, uses 3 hours extremely complete mix homogeneously of magnetic stirrer under room temperature state, obtain coating material, stand-by;
B) coating of heart yarn and knitting yarn
Coating material is placed in to maceration tank 4 and the immersion tank 10 of plater, use plater respectively the heart yarn to doubling twisting (3 strands × 6) and knitting yarn (2 strands × 2) carry out 2 antimicrobial coating processing, the process of antimicrobial coating processing is identical with embodiment 1 at every turn.
C) braiding of coated yarn
The braiding of coated yarn is identical with embodiment 3.
The prepared antibacterial bandwidth of sutural maximum (being the antibacterial bandwidth of the antibacterial first day): is (13.91 ± 0.15) mm to staphylococcus aureus; Be (14.23 ± 0.38) mm to escherichia coli; Durability of antimicrobial effect: is 4 days to staphylococcus aureus; It is 5 days to escherichia coli.The experiment proved that this antibacterial stitching thread has good antibiotic property and Durability of antimicrobial effect.
Embodiment 5:
As shown in Figure 2, for plater structural representation, described plater is made up of coating area A and arid region B, in described coating area A, be at least provided with maceration tank 4, the first dip roll 5, first heater 6, the first pressure roll, the first deflector roll 9, immersion tank 10, the second dip roll 11, secondary heating mechanism 12 and the second pressure roll, in described arid region B, be at least provided with the second deflector roll 15, the 3rd deflector roll 16 and cylinder 17, the first dip roll 5 and the second dip roll 11 are located at respectively in maceration tank 4 and immersion tank 10, maceration tank 4 and immersion tank 10 are located at respectively on first heater 6 and secondary heating mechanism 12, the first pressure roll is made up of the first rubber rollers 7 and the first stainless steel rider 8 of being located under it, the first pressure roll is located between maceration tank 4 and immersion tank 10, the first deflector roll 9 is located between the first pressure roll and maceration tank 4, the second pressure roll is made up of the second rubber rollers 13 and the second stainless steel rider 14 of being located under it, the second pressure roll is located between immersion tank 10 and cylinder 17, the second deflector roll 15 and the 3rd deflector roll 16 are located between the second pressure roll and cylinder 17.The length of described arid region B is 4 meters.
As shown in Figure 1, for long-acting slow-release anti-bacteria real silk Weaving type suture structural representation, described long-acting slow-release anti-bacteria real silk Weaving type suture by heart yarn 1 and knitting yarn 2 form, heart yarn 1 and knitting yarn 2 are woven together, described heart yarn 1 and the surface of knitting yarn 2 are all coated with antimicrobial coating 3, contain molecular weight and be 50,000 chitosan and levofloxacin medicine in described antimicrobial coating 3.Its preparation method is:
A) preparation of coating material
The chitosan that is 50,000 by molecular weight is dissolved in 2% glacial acetic acid solution, make mass fraction and be 5% chitosan solution, under normal temperature environment, use 4 hours extremely complete mix homogeneously of magnetic stirrer, get 10ml and mix chitosan solution completely, the levofloxacin drug powder that adds 0.01g to grind completely, in gained mixture, the concentration of levofloxacin medicine is 1000 μ g/ml, uses 3 hours extremely complete mix homogeneously of magnetic stirrer under room temperature state, obtain coating material, stand-by;
B) coating of heart yarn and knitting yarn
Coating material is placed in to maceration tank 4 and the immersion tank 10 of plater, use plater respectively the heart yarn to doubling twisting (2 strands × 4) and knitting yarn (3 strands × 1) carry out 3 antimicrobial coating processing, the process of antimicrobial coating processing is identical with embodiment 1 at every turn.
C) braiding of coated yarn
The braiding of coated yarn is identical with embodiment 1.
The prepared antibacterial bandwidth of sutural maximum (being the antibacterial bandwidth of the antibacterial first day): is (10.92 ± 0.08) mm to staphylococcus aureus; Be (10.96 ± 0.87) mm to escherichia coli; Durability of antimicrobial effect: is 3 days to staphylococcus aureus; It is 3 days to escherichia coli.The experiment proved that this antibacterial stitching thread has certain antibiotic property and Durability of antimicrobial effect.
Embodiment 6:
As shown in Figure 2, for plater structural representation, described plater is made up of coating area A and arid region B, in described coating area A, be at least provided with maceration tank 4, the first dip roll 5, first heater 6, the first pressure roll, the first deflector roll 9, immersion tank 10, the second dip roll 11, secondary heating mechanism 12 and the second pressure roll, in described arid region B, be at least provided with the second deflector roll 15, the 3rd deflector roll 16 and cylinder 17, the first dip roll 5 and the second dip roll 11 are located at respectively in maceration tank 4 and immersion tank 10, maceration tank 4 and immersion tank 10 are located at respectively on first heater 6 and secondary heating mechanism 12, the first pressure roll is made up of the first rubber rollers 7 and the first stainless steel rider 8 of being located under it, the first pressure roll is located between maceration tank 4 and immersion tank 10, the first deflector roll 9 is located between the first pressure roll and maceration tank 4, the second pressure roll is made up of the second rubber rollers 13 and the second stainless steel rider 14 of being located under it, the second pressure roll is located between immersion tank 10 and cylinder 17, the second deflector roll 15 and the 3rd deflector roll 16 are located between the second pressure roll and cylinder 17.The length of described arid region B is 4 meters.
As shown in Figure 1, for long-acting slow-release anti-bacteria real silk Weaving type suture structural representation, described long-acting slow-release anti-bacteria real silk Weaving type suture by heart yarn 1 and knitting yarn 2 form, heart yarn 1 and knitting yarn 2 are woven together, described heart yarn 1 and the surface of knitting yarn 2 are all coated with antimicrobial coating 3, contain molecular weight and be 200,000 chitosan and levofloxacin medicine in described antimicrobial coating 3.Its preparation method is:
A) preparation of coating material
The chitosan that is 200,000 by molecular weight is dissolved in 2% glacial acetic acid solution, make mass fraction and be 4% chitosan solution, under normal temperature environment, use 7 hours extremely complete mix homogeneously of magnetic stirrer, get 10ml and mix chitosan solution completely, the levofloxacin drug powder that adds 0.024g to grind completely, in gained mixture, the concentration of levofloxacin medicine is 2400 μ g/ml, under room temperature state, use 3 hours extremely complete mix homogeneously of magnetic stirrer, obtain coating material, stand-by;
B) coating of heart yarn and knitting yarn
Coating material is placed in to maceration tank 4 and the immersion tank 10 of plater, use plater respectively the heart yarn to doubling twisting (2 strands × 4) and knitting yarn (3 strands × 1) carry out 2 antimicrobial coating processing, the process of antimicrobial coating processing is identical with embodiment 1 at every turn.
C) braiding of coated yarn
The braiding of coated yarn is identical with embodiment 1.
The prepared antibacterial bandwidth of sutural maximum (being the antibacterial bandwidth of the antibacterial first day): is (11.77 ± 0.58) mm to staphylococcus aureus; Be (11.92 ± 0.37) mm to escherichia coli; Durability of antimicrobial effect: is 4 days to staphylococcus aureus; It is 5 days to escherichia coli.The experiment proved that this antibacterial stitching thread has good antibiotic property and Durability of antimicrobial effect.
Embodiment 7:
As shown in Figure 2, for plater structural representation, described plater is made up of coating area A and arid region B, in described coating area A, be at least provided with maceration tank 4, the first dip roll 5, first heater 6, the first pressure roll, the first deflector roll 9, immersion tank 10, the second dip roll 11, secondary heating mechanism 12 and the second pressure roll, in described arid region B, be at least provided with the second deflector roll 15, the 3rd deflector roll 16 and cylinder 17, the first dip roll 5 and the second dip roll 11 are located at respectively in maceration tank 4 and immersion tank 10, maceration tank 4 and immersion tank 10 are located at respectively on first heater 6 and secondary heating mechanism 12, the first pressure roll is made up of the first rubber rollers 7 and the first stainless steel rider 8 of being located under it, the first pressure roll is located between maceration tank 4 and immersion tank 10, the first deflector roll 9 is located between the first pressure roll and maceration tank 4, the second pressure roll is made up of the second rubber rollers 13 and the second stainless steel rider 14 of being located under it, the second pressure roll is located between immersion tank 10 and cylinder 17, the second deflector roll 15 and the 3rd deflector roll 16 are located between the second pressure roll and cylinder 17.The length of described arid region B is 4 meters.
As shown in Figure 1, for long-acting slow-release anti-bacteria real silk Weaving type suture structural representation, described long-acting slow-release anti-bacteria real silk Weaving type suture by heart yarn 1 and knitting yarn 2 form, heart yarn 1 and knitting yarn 2 are woven together, described heart yarn 1 and the surface of knitting yarn 2 are all coated with antimicrobial coating 3, contain molecular weight and be 120,000 chitosan and levofloxacin medicine in described antimicrobial coating 3.Its preparation method is:
A) preparation of coating material
The chitosan that is 120,000 by molecular weight is dissolved in 2% glacial acetic acid solution, make mass fraction and be 2% chitosan solution, under normal temperature environment, use 6 hours extremely complete mix homogeneously of magnetic stirrer, get 10ml and mix chitosan solution completely, the levofloxacin drug powder that adds 0.05g to grind completely, in gained mixture, the concentration of levofloxacin medicine is 5000 μ g/ml, under room temperature state, use 3 hours extremely complete mix homogeneously of magnetic stirrer, obtain coating material, stand-by;
B) coating of heart yarn and knitting yarn
Coating material is placed in to maceration tank 4 and the immersion tank 10 of plater, use plater respectively the heart yarn to doubling twisting (3 strands × 6) and knitting yarn (2 strands × 2) carry out 3 antimicrobial coating processing, the process of antimicrobial coating processing is identical with embodiment 1 at every turn.
C) braiding of coated yarn
The braiding of coated yarn is identical with embodiment 3.
The prepared antibacterial bandwidth of sutural maximum (being the antibacterial bandwidth of the antibacterial first day): is (11.21 ± 0.33) mm to staphylococcus aureus; Be (11.96 ± 0.71) mm to escherichia coli; Durability of antimicrobial effect: is 3 days to staphylococcus aureus; It is 4 days to escherichia coli.The experiment proved that this antibacterial stitching thread has certain antibiotic property and Durability of antimicrobial effect.
Embodiment 8:
As shown in Figure 2, for plater structural representation, described plater is made up of coating area A and arid region B, in described coating area A, be at least provided with maceration tank 4, the first dip roll 5, first heater 6, the first pressure roll, the first deflector roll 9, immersion tank 10, the second dip roll 11, secondary heating mechanism 12 and the second pressure roll, in described arid region B, be at least provided with the second deflector roll 15, the 3rd deflector roll 16 and cylinder 17, the first dip roll 5 and the second dip roll 11 are located at respectively in maceration tank 4 and immersion tank 10, maceration tank 4 and immersion tank 10 are located at respectively on first heater 6 and secondary heating mechanism 12, the first pressure roll is made up of the first rubber rollers 7 and the first stainless steel rider 8 of being located under it, the first pressure roll is located between maceration tank 4 and immersion tank 10, the first deflector roll 9 is located between the first pressure roll and maceration tank 4, the second pressure roll is made up of the second rubber rollers 13 and the second stainless steel rider 14 of being located under it, the second pressure roll is located between immersion tank 10 and cylinder 17, the second deflector roll 15 and the 3rd deflector roll 16 are located between the second pressure roll and cylinder 17.The length of described arid region B is 4 meters.
As shown in Figure 1, for long-acting slow-release anti-bacteria real silk Weaving type suture structural representation, described long-acting slow-release anti-bacteria real silk Weaving type suture by heart yarn 1 and knitting yarn 2 form, heart yarn 1 and knitting yarn 2 are woven together, described heart yarn 1 and the surface of knitting yarn 2 are all coated with antimicrobial coating 3, contain molecular weight and be 70,000 polylactic acid and levofloxacin medicine in described antimicrobial coating 3.Its preparation method is:
A) preparation of coating material
The polylactic acid that is 70,000 by molecular weight is dissolved in chloroform, make mass fraction and be 7% polylactic acid solution, under normal temperature environment, use 5 hours extremely complete mix homogeneously of magnetic stirrer, get 10ml and mix polylactic acid solution completely, the levofloxacin drug powder that adds 0.015g to grind completely, in gained mixture, the concentration of levofloxacin medicine is 1500 μ g/ml, uses 3 hours extremely complete mix homogeneously of magnetic stirrer under room temperature state, obtain coating material, stand-by;
B) coating of heart yarn and knitting yarn
Coating material is placed in to maceration tank 4 and the immersion tank 10 of plater, use plater respectively the heart yarn to doubling twisting (2 strands × 4) and knitting yarn (3 strands × 1) carry out 1 antimicrobial coating processing, the process of antimicrobial coating processing is identical with embodiment 1 at every turn.
C) braiding of coated yarn
The braiding of coated yarn is identical with embodiment 1.
The prepared antibacterial bandwidth of sutural maximum (being the antibacterial bandwidth of the antibacterial first day): is (10.42 ± 0.56) mm to staphylococcus aureus; Be (10.98 ± 0.75) mm to escherichia coli; Durability of antimicrobial effect: is 4 days to staphylococcus aureus; It is 4 days to escherichia coli.The experiment proved that this antibacterial stitching thread has certain antibiotic property and Durability of antimicrobial effect.
Embodiment 9:
As shown in Figure 2, for plater structural representation, described plater is made up of coating area A and arid region B, in described coating area A, be at least provided with maceration tank 4, the first dip roll 5, first heater 6, the first pressure roll, the first deflector roll 9, immersion tank 10, the second dip roll 11, secondary heating mechanism 12 and the second pressure roll, in described arid region B, be at least provided with the second deflector roll 15, the 3rd deflector roll 16 and cylinder 17, the first dip roll 5 and the second dip roll 11 are located at respectively in maceration tank 4 and immersion tank 10, maceration tank 4 and immersion tank 10 are located at respectively on first heater 6 and secondary heating mechanism 12, the first pressure roll is made up of the first rubber rollers 7 and the first stainless steel rider 8 of being located under it, the first pressure roll is located between maceration tank 4 and immersion tank 10, the first deflector roll 9 is located between the first pressure roll and maceration tank 4, the second pressure roll is made up of the second rubber rollers 13 and the second stainless steel rider 14 of being located under it, the second pressure roll is located between immersion tank 10 and cylinder 17, the second deflector roll 15 and the 3rd deflector roll 16 are located between the second pressure roll and cylinder 17.The length of described arid region B is 4 meters.
As shown in Figure 1, for long-acting slow-release anti-bacteria real silk Weaving type suture structural representation, described long-acting slow-release anti-bacteria real silk Weaving type suture by heart yarn 1 and knitting yarn 2 form, heart yarn 1 and knitting yarn 2 are woven together, described heart yarn 1 and the surface of knitting yarn 2 are all coated with antimicrobial coating 3, contain molecular weight and be 120,000 polylactic acid and levofloxacin medicine in described antimicrobial coating 3.Its preparation method is:
A) preparation of coating material
The polylactic acid that is 120,000 by molecular weight is dissolved in chloroform, make mass fraction and be 7% polylactic acid solution, under normal temperature environment, use 5 hours extremely complete mix homogeneously of magnetic stirrer, get 10ml and mix polylactic acid solution completely, the levofloxacin drug powder that adds 0.05g to grind completely, in gained mixture, the concentration of levofloxacin medicine is 5000 μ g/ml, uses 3 hours extremely complete mix homogeneously of magnetic stirrer under room temperature state, obtain coating material, stand-by;
B) coating of heart yarn and knitting yarn
Coating material is placed in to maceration tank 4 and the immersion tank 10 of plater, use plater respectively the heart yarn to doubling twisting (3 strands × 6) and knitting yarn (2 strands × 2) carry out 3 antimicrobial coating processing, the process of antimicrobial coating processing is identical with embodiment 1 at every turn.
C) braiding of coated yarn
The braiding of coated yarn is identical with embodiment 3.
The prepared antibacterial bandwidth of sutural maximum (being the antibacterial bandwidth of the antibacterial first day): is (12.79 ± 0.57) mm to staphylococcus aureus; Be (13.15 ± 0.20) mm to escherichia coli; Durability of antimicrobial effect: is 5 days to staphylococcus aureus; It is 6 days to escherichia coli.The experiment proved that this antibacterial stitching thread has good antibiotic property and Durability of antimicrobial effect.
Claims (10)
1. a long-acting slow-release anti-bacteria real silk Weaving type suture, it is characterized in that, comprise the heart yarn (1) and the knitting yarn (2) that are woven together, wherein, the surface of described heart yarn (1) and knitting yarn (2) is all coated with antimicrobial coating (3).
2. long-acting slow-release anti-bacteria real silk Weaving type suture as claimed in claim 1, is characterized in that, in described antimicrobial coating (3), contains macromolecule absorbable material and carbostyril family antibacterial drugs.
3. long-acting slow-release anti-bacteria real silk Weaving type suture as claimed in claim 2, is characterized in that, described carbostyril family antibacterial drugs is levofloxacin, levofloxacin hydrochloride or levofloxacin lactate.
4. long-acting slow-release anti-bacteria real silk Weaving type suture as claimed in claim 2, is characterized in that, described macromolecule absorbable material is polycaprolactone, chitosan or polylactic acid.
5. long-acting slow-release anti-bacteria real silk Weaving type suture as claimed in claim 4, is characterized in that, the molecular weight of described polycaprolactone is 5～180,000, and the molecular weight of chitosan is 3～200,000, and the molecular weight of polylactic acid is 5～120,000.
6. the preparation method of the long-acting slow-release anti-bacteria real silk Weaving type suture described in any one in claim 1-5, is characterized in that, concrete steps comprise:
The first step: macromolecule absorbable material is dissolved in and obtains macromolecule absorbable material solution in corresponding solvent, under normal temperature environment, use 2～8 hours extremely complete mix homogeneously of magnetic stirrer, add the carbostyril family antibacterial drugs powder grinding, in gained mixture, the concentration of carbostyril family antibacterial drugs is 1000～5000 μ g/ml, under room temperature state, with magnetic stirrer mix homogeneously extremely completely, obtain coating material;
Second step: coating material is placed in to plater, and the heart yarn to doubling twisting and knitting yarn carry out 1～3 antimicrobial coating processing respectively to use plater;
The 3rd step: adopt the medical special braider of 12 ingot or the medical special braider of 16 ingots to be woven together heart yarn after treatment antimicrobial coating and knitting yarn, obtain long-acting slow-release anti-bacteria real silk Weaving type suture.
7. the preparation method of long-acting slow-release anti-bacteria real silk Weaving type suture as claimed in claim 6, it is characterized in that, when described macromolecule absorbable material is polycaprolactone, the concentration of macromolecule absorbable material solution is 5%～10%, when described macromolecule absorbable material is chitosan, the concentration of macromolecule absorbable material solution is 2%～5%, and when described macromolecule absorbable material is polylactic acid, the concentration of macromolecule absorbable material solution is 2%～7%.
8. the preparation method of long-acting slow-release anti-bacteria real silk Weaving type suture as claimed in claim 6, it is characterized in that, plater in described second step is made up of coating area (A) and arid region (B), in described coating area (A), be at least provided with maceration tank (4), the first dip roll (5), first heater (6), the first pressure roll, the first deflector roll (9), immersion tank (10), the second dip roll (11), secondary heating mechanism (12), with the second pressure roll, in described arid region (B), be at least provided with the second deflector roll (15), the 3rd deflector roll (16) and cylinder (17), the first dip roll (5) and the second dip roll (11) are located at respectively in maceration tank (4) and immersion tank (10), maceration tank (4) and immersion tank (10) are located at respectively on first heater (6) and secondary heating mechanism (12), the first pressure roll is made up of the first rubber rollers (7) and the first stainless steel rider (8) of being located under it, the first pressure roll is located between maceration tank (4) and immersion tank (10), the first deflector roll (9) is located between the first pressure roll and maceration tank (4), the second pressure roll is made up of the second rubber rollers (13) and the second stainless steel rider (14) of being located under it, the second pressure roll is located between immersion tank (10) and cylinder (17), the second deflector roll (15) and the 3rd deflector roll (16) are located between the second pressure roll and cylinder (17).
9. the preparation method of long-acting slow-release anti-bacteria real silk Weaving type suture as claimed in claim 8, is characterized in that, the length of described arid region B is 4～6 meters.
10. the preparation method of long-acting slow-release anti-bacteria real silk Weaving type suture as claimed in claim 6, it is characterized in that, in described second step, coating material is placed in to maceration tank (4) and the immersion tank (10) of plater, the process of each antimicrobial coating processing is: by first heater (6) and secondary heating mechanism (12), the coating material in maceration tank (4) and immersion tank (10) is maintained to 45 ℃ of constant temperature respectively, the heart yarn of doubling twisting or knitting yarn are immersed in the maceration tank (4) in coating area (A), heart yarn or knitting yarn are successively by the first dip roll (5) and the first pressure roll, be passed to immersion tank (10) through the first deflector roll (9), heart yarn or knitting yarn are successively by the second dip roll (11) and the second pressure roll, enter again in arid region (B) and carry out normal temperature drying, heart yarn or knitting yarn are successively through the second deflector roll (15) and the 3rd deflector roll (16), finally be wound on cylinder (17).
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Application publication date: 20140528 |