CN112402301A - Silicone-oil-free shampoo composition with softening and repairing effects and preparation method and application thereof - Google Patents
Silicone-oil-free shampoo composition with softening and repairing effects and preparation method and application thereof Download PDFInfo
- Publication number
- CN112402301A CN112402301A CN202011351988.8A CN202011351988A CN112402301A CN 112402301 A CN112402301 A CN 112402301A CN 202011351988 A CN202011351988 A CN 202011351988A CN 112402301 A CN112402301 A CN 112402301A
- Authority
- CN
- China
- Prior art keywords
- hair
- ammonium chloride
- parts
- shampoo composition
- keratin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002453 shampoo Substances 0.000 title claims abstract description 54
- 239000000203 mixture Substances 0.000 title claims abstract description 41
- 230000000694 effects Effects 0.000 title claims abstract description 21
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 210000004209 hair Anatomy 0.000 claims abstract description 77
- 102000011782 Keratins Human genes 0.000 claims abstract description 46
- 108010076876 Keratins Proteins 0.000 claims abstract description 46
- 235000018936 Vitellaria paradoxa Nutrition 0.000 claims abstract description 22
- 241001135917 Vitellaria paradoxa Species 0.000 claims abstract description 22
- -1 propyl dimethyl ammonium chloride phosphate Chemical compound 0.000 claims abstract description 22
- 229940057910 shea butter Drugs 0.000 claims abstract description 22
- 229920006322 acrylamide copolymer Polymers 0.000 claims abstract description 19
- QYUMESOEHIJKHV-UHFFFAOYSA-M prop-2-enamide;trimethyl(propyl)azanium;chloride Chemical compound [Cl-].NC(=O)C=C.CCC[N+](C)(C)C QYUMESOEHIJKHV-UHFFFAOYSA-M 0.000 claims abstract description 19
- 125000005456 glyceride group Chemical group 0.000 claims abstract description 18
- QEALYLRSRQDCRA-UHFFFAOYSA-N myristamide Chemical compound CCCCCCCCCCCCCC(N)=O QEALYLRSRQDCRA-UHFFFAOYSA-N 0.000 claims abstract description 18
- 229920001296 polysiloxane Polymers 0.000 claims abstract description 9
- 229920000289 Polyquaternium Polymers 0.000 claims abstract description 8
- 238000012360 testing method Methods 0.000 claims description 29
- 238000003756 stirring Methods 0.000 claims description 10
- 239000002994 raw material Substances 0.000 claims description 9
- 239000004094 surface-active agent Substances 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium group Chemical class [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 6
- 239000002738 chelating agent Substances 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 6
- 229940083542 sodium Drugs 0.000 claims description 6
- 239000011734 sodium Substances 0.000 claims description 6
- 229910052708 sodium Inorganic materials 0.000 claims description 6
- 239000002562 thickening agent Substances 0.000 claims description 6
- 239000008367 deionised water Substances 0.000 claims description 5
- 229910021641 deionized water Inorganic materials 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- 238000005303 weighing Methods 0.000 claims description 5
- ZEYHEAKUIGZSGI-UHFFFAOYSA-N 4-methoxybenzoic acid Chemical compound COC1=CC=C(C(O)=O)C=C1 ZEYHEAKUIGZSGI-UHFFFAOYSA-N 0.000 claims description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 4
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 4
- 239000003755 preservative agent Substances 0.000 claims description 4
- 230000002335 preservative effect Effects 0.000 claims description 4
- 238000007599 discharging Methods 0.000 claims description 3
- 238000011049 filling Methods 0.000 claims description 3
- 239000012467 final product Substances 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 238000005070 sampling Methods 0.000 claims description 3
- KZRXPHCVIMWWDS-AWEZNQCLSA-N (4S)-4-amino-5-dodecanoyloxy-5-oxopentanoic acid Chemical compound CCCCCCCCCCCC(=O)OC(=O)[C@@H](N)CCC(O)=O KZRXPHCVIMWWDS-AWEZNQCLSA-N 0.000 claims description 2
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 2
- DDGPBVIAYDDWDH-UHFFFAOYSA-N 3-[dodecyl(dimethyl)azaniumyl]-2-hydroxypropane-1-sulfonate Chemical compound CCCCCCCCCCCC[N+](C)(C)CC(O)CS([O-])(=O)=O DDGPBVIAYDDWDH-UHFFFAOYSA-N 0.000 claims description 2
- JDRSMPFHFNXQRB-CMTNHCDUSA-N Decyl beta-D-threo-hexopyranoside Chemical compound CCCCCCCCCCO[C@@H]1O[C@H](CO)C(O)[C@H](O)C1O JDRSMPFHFNXQRB-CMTNHCDUSA-N 0.000 claims description 2
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 claims description 2
- OVBJJZOQPCKUOR-UHFFFAOYSA-L EDTA disodium salt dihydrate Chemical group O.O.[Na+].[Na+].[O-]C(=O)C[NH+](CC([O-])=O)CC[NH+](CC([O-])=O)CC([O-])=O OVBJJZOQPCKUOR-UHFFFAOYSA-L 0.000 claims description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims description 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 claims description 2
- 150000003863 ammonium salts Chemical group 0.000 claims description 2
- 230000002421 anti-septic effect Effects 0.000 claims description 2
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 claims description 2
- 229940073507 cocamidopropyl betaine Drugs 0.000 claims description 2
- 229940073499 decyl glucoside Drugs 0.000 claims description 2
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 claims description 2
- 229940071085 lauroyl glutamate Drugs 0.000 claims description 2
- 229940044591 methyl glucose dioleate Drugs 0.000 claims description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims description 2
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims description 2
- 229960002216 methylparaben Drugs 0.000 claims description 2
- 229960005323 phenoxyethanol Drugs 0.000 claims description 2
- 108700004121 sarkosyl Proteins 0.000 claims description 2
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 2
- 235000010234 sodium benzoate Nutrition 0.000 claims description 2
- 239000004299 sodium benzoate Substances 0.000 claims description 2
- 229960003885 sodium benzoate Drugs 0.000 claims description 2
- 229940065859 sodium cocoyl glycinate Drugs 0.000 claims description 2
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 claims description 2
- 229940045885 sodium lauroyl sarcosinate Drugs 0.000 claims description 2
- IKGKWKGYFJBGQJ-UHFFFAOYSA-M sodium;2-(dodecanoylamino)acetate Chemical compound [Na+].CCCCCCCCCCCC(=O)NCC([O-])=O IKGKWKGYFJBGQJ-UHFFFAOYSA-M 0.000 claims description 2
- 229940104261 taurate Drugs 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 abstract description 7
- 108090000623 proteins and genes Proteins 0.000 abstract description 7
- 230000009286 beneficial effect Effects 0.000 abstract description 4
- 239000003093 cationic surfactant Substances 0.000 abstract description 3
- 229920000642 polymer Polymers 0.000 abstract description 3
- 239000002537 cosmetic Substances 0.000 abstract description 2
- 239000003292 glue Substances 0.000 abstract description 2
- 230000001771 impaired effect Effects 0.000 abstract description 2
- 239000000463 material Substances 0.000 abstract description 2
- 230000010069 protein adhesion Effects 0.000 abstract description 2
- 239000000047 product Substances 0.000 description 29
- 238000009960 carding Methods 0.000 description 9
- 239000000835 fiber Substances 0.000 description 7
- 229920002545 silicone oil Polymers 0.000 description 7
- 238000005406 washing Methods 0.000 description 7
- 235000018102 proteins Nutrition 0.000 description 6
- 230000003750 conditioning effect Effects 0.000 description 5
- 210000003491 skin Anatomy 0.000 description 4
- 238000001035 drying Methods 0.000 description 3
- 239000000693 micelle Substances 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 210000004761 scalp Anatomy 0.000 description 3
- 239000008399 tap water Substances 0.000 description 3
- 235000020679 tap water Nutrition 0.000 description 3
- 238000010998 test method Methods 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 238000005034 decoration Methods 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 201000004384 Alopecia Diseases 0.000 description 1
- 206010003694 Atrophy Diseases 0.000 description 1
- 208000001840 Dandruff Diseases 0.000 description 1
- 206010016322 Feeling abnormal Diseases 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 231100000360 alopecia Toxicity 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- 238000005282 brightening Methods 0.000 description 1
- 229920006317 cationic polymer Polymers 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 239000004205 dimethyl polysiloxane Substances 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000013020 final formulation Substances 0.000 description 1
- 230000003648 hair appearance Effects 0.000 description 1
- 210000003780 hair follicle Anatomy 0.000 description 1
- 235000001705 insufficient nutrition Nutrition 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 150000002605 large molecules Chemical class 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- LPUQAYUQRXPFSQ-DFWYDOINSA-M monosodium L-glutamate Chemical compound [Na+].[O-]C(=O)[C@@H](N)CCC(O)=O LPUQAYUQRXPFSQ-DFWYDOINSA-M 0.000 description 1
- 235000013923 monosodium glutamate Nutrition 0.000 description 1
- 239000004223 monosodium glutamate Substances 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000004792 oxidative damage Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 230000036561 sun exposure Effects 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8158—Homopolymers or copolymers of amides or imides, e.g. (meth) acrylamide; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/002—Preparations for repairing the hair, e.g. hair cure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
- A61K2800/34—Free of silicones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/54—Polymers characterized by specific structures/properties
- A61K2800/542—Polymers characterized by specific structures/properties characterized by the charge
- A61K2800/5426—Polymers characterized by specific structures/properties characterized by the charge cationic
Abstract
The invention belongs to the field of cosmetics, and particularly relates to a silicone oil-free shampoo composition with softening and repairing effects, and a preparation method and application thereof. The silicone-oil-free shampoo composition comprises the following components in parts by mass: 0.1-0.5 part of acrylamide propyl trimethyl ammonium chloride/acrylamide copolymer, 100.1-0.5 part of polyquaternium, 1-5 parts of PEG-75 shea butter glyceride, 1-5 parts of keratin and hydrolyzed keratin, and 0.5-2 parts of myristamide propyl dimethyl ammonium chloride phosphate. This patent drives more polymer/oil wadding glues and adsorbs the impaired position of hair through cationic surfactant, and protein closely combines with polyquaternium material again simultaneously, improves the mode of protein adhesion strength on the hair, will as far as possible beneficial component adhere to on the hair, and then reach the purpose of moist, gentle and agreeable, glossy hair.
Description
Technical Field
The invention belongs to the field of cosmetics, and particularly relates to a silicone oil-free shampoo composition with softening and repairing effects, and a preparation method and application thereof.
Background
People often feel that hair is soft and smooth after washing the hair or using hair conditioners, because the used products may contain silicone oil, and if the components of the used products are carefully observed, the used products mostly contain polydimethylsiloxane, dimethiconol, amodimethicone and the like. This silicone oil is a water insoluble and chemically stable mineral oil that was added to personal care products in the early 50 s and became one of the most common components of shampoos and conditioners in the 70 s. Although the silicone oil is non-toxic and non-irritant to skin and mucous membranes, the silicone oil can be attached to the gaps of the hair scales in the using process to fill and level the surfaces of the hair, so that the hair quality repairing effect is brought, and the hair becomes smooth. However, since the silicone oil is not very soluble, after a certain number of times or for a certain period of time, the residue of the silicone oil which is not dissolved or metabolized is slowly accumulated around the hair, tightly surrounding the outside of the hair, and thickening the hair. Even the pores on the scalp are blocked by insoluble silicone oil, and although the scalp does not grow acne due to oil stain blockage like the skin, hair can cause the phenomena of atrophy of hair follicles, increase of dandruff, alopecia and the like of the scalp due to insufficient nutrition. In recent years, the healthier concept of silicone oil-free shampoos has begun to penetrate slowly and prevail.
Disclosure of Invention
In order to effectively solve the problems in the background art, the invention provides a silicone oil-free shampoo composition with softening and repairing effects and a preparation method and application thereof, and the specific technical scheme is as follows;
a silicone oil-free shampoo composition with softening and repairing effects comprises the following components in parts by mass: 0.1-0.5 part of acrylamide propyl trimethyl ammonium chloride/acrylamide copolymer, 100.1-0.5 part of polyquaternium, 1-5 parts of PEG-75 shea butter glyceride, 1-5 parts of keratin and hydrolyzed keratin, and 0.5-2 parts of myristamide propyl dimethyl ammonium chloride phosphate.
Preferably, the composition comprises the following components in parts by mass: 0.2 part of acrylamide propyl trimethyl ammonium chloride/acrylamide copolymer, 100.1 parts of polyquaternary ammonium salt, 2 parts of PEG-75 shea butter glyceride, 1 part of keratin and hydrolyzed keratin, and 0.5 part of myristamide propyl dimethyl ammonium chloride phosphate.
The invention also comprises a preparation method of the silicone oil-free shampoo composition with softening and repairing effects, which comprises the following steps: the preparation method comprises the following specific steps:
(1) weighing acrylamide propyl trimethyl ammonium chloride/acrylamide copolymer, polyquaternary ammonium salt-10, PEG-75 shea butter glyceride, keratin, hydrolyzed keratin and myristamide propyl dimethyl ammonium chloride phosphate as raw materials according to the formula amount;
(2) uniformly mixing acrylamide propyl trimethyl ammonium chloride/acrylamide copolymer, polyquaternary ammonium salt-10, PEG-75 shea butter glyceride, keratin, hydrolyzed keratin and myristamide propyl dimethyl ammonium chloride phosphate to obtain the final product.
The invention also comprises the application of the silicone oil-free shampoo composition with softening and repairing effects, which is applied to shampoo; the shampoo composition has a content of 4-15 wt% in the shampoo.
Wherein, the shampoo is prepared by the following method:
(1) weighing deionized water, a surfactant, a chelating agent and a thickening agent, adding the deionized water, the surfactant, the chelating agent and the thickening agent into a reaction kettle, starting stirring, adjusting the revolution of a scraper stirrer to 60 revolutions per minute, starting a heating switch, controlling the temperature to be 70-80 ℃, stirring until the raw materials are completely dissolved, and then cooling;
(2) cooling to 45-55 deg.C, adding the shampoo composition, essence, antiseptic, and pH regulator, stirring, breaking vacuum, sampling, testing, and discharging;
(3) standing for 24 hours, and filling when the temperature is lower than 38 ℃.
The surfactant is one or any combination of sodium cocoyl methyl taurate, sodium cocoamido propionate, sodium cocoyl glycinate, sodium lauroyl sarcosinate, sodium lauroyl amphoacetate, cocamidopropyl betaine, lauryl hydroxy sulfobetaine and decyl glucoside, the dosage is 5-30%, and the chelating agent is disodium EDTA, the dosage is 0.1%; the thickener is one or any combination of PEG-120 methyl glucose dioleate, distearyl polyether-5 lauroyl glutamate, cocamide MEA, cocamide methyl MEA, and C12-15 alcohol lactate, and the use amount is 1% -5%; the amount of the essence is 0.2-0.5%; the preservative is one or any combination of anisic acid, phenoxyethanol, methyl paraben and sodium benzoate, and the dosage of the preservative is 0.3-0.9%.
Compared with the prior art, the invention has the beneficial effects that:
the invention creatively combines acrylamide propyl trimethyl ammonium chloride/acrylamide copolymer, polyquaternium-10, PEG-75 shea butter glyceride, keratin, hydrolyzed keratin and myristamide propyl dimethyl ammonium chloride phosphate, wherein the acrylamide propyl trimethyl ammonium chloride/acrylamide copolymer is a high molecular weight cationic surfactant, has positive charges, can be combined with negative charge particles on hair, and can be easily adsorbed on the hair, and meanwhile, the relative molecular mass of the acrylamide propyl trimethyl ammonium chloride/acrylamide copolymer is high, which means that more polymer/oil wadding gum can be driven to be adsorbed on the damaged part of the hair, and the polyquaternium-10 and shea butter are also added in the composition aiming at the point.
The polyquaternium-10 is also a cationic polymer, is not added in a large amount but has a very important function, is equivalent to industrial monosodium glutamate, can neutralize negative charges on hair to achieve an antistatic effect when being applied to a shampoo formula, has strong wrapping and adsorption properties on other hair care components due to high nitrogen content, can deposit various beneficial components on the surface of the hair to play a role in conditioning, endows the hair with excellent wetting and combing capabilities, and is particularly effective in anti-twisting performance of the hair.
PEG-75 shea butter glyceride belongs to ethoxylated shea butter, is in a liquid state, can be dissolved with most formulas even with high content compared with solid raw materials, does not influence the foamability of cleaning formulas, also keeps the bioactivity of a plurality of solid shea butter, moisturizes and imparts soft feeling to skin, can effectively improve the combing performance of hair when applied to hair products, and enables the hair to be soft and glossy. Most importantly, ethoxylated shea butter has a very low Critical Micelle Concentration (CMC) and allows low molecular weight irritating surfactants to be incorporated into the micelles, since the larger molecules and those in the micelle structure are much less penetrating into the human skin tissue structure than those of the free surfactant monomers, thus reducing irritation of the cleansing-type formulation and resulting in a milder product.
Keratin and hydrolyzed keratin: when the hair is subjected to chemical treatment, pollution, mechanical damage and sun exposure, the structure of hair fibers can be damaged, protein is lost and scales fall off, the hair fibers become porous and split, the hair is dry/brittle, and the hair tail is split, keratin and hydrolyzed keratin with better hair affinity in the composition can be better combined with the outer surface of the hair scales, wherein small-molecule keratin can supplement the lacking keratin for the hair, and large-molecule keratin can form a tightly combined film on the epidermis of the hair and permeate into the cortex, so that the aims of moisturizing, brightening the hair and endowing the hair with certain strength are fulfilled. The keratin and hydrolyzed protein in the composition also contain a high proportion of cysteine, and the amino acid has antioxidant activity and can reduce oxidative damage to the protein and lipid components of hair when exposed to sunlight for a long period of time. Most importantly, the hydrolyzed keratin can be combined with the polyquaternium substance in the composition in a covalent bond mode to improve the isoelectric point of the protein, further improve the affinity of the hydrolyzed keratin on hair and improve the adhesion strength of the hydrolyzed protein on the hair, so that the hair is easier to comb and healthier to look like.
In addition, the composition is added with esters, namely myristamide propane dimethyl ammonium chloride phosphate, so that the solubility of the functional components is increased, the product can form a thicker and more uniform film on hair, and the hair is smoother and more glossy.
This patent drives more polymer/oil wadding glues and adsorbs the impaired position of hair through cationic surfactant, and protein closely combines with polyquaternium material again simultaneously, improves the mode of protein adhesion strength on the hair, will as far as possible beneficial component adhere to on the hair, and then reach the purpose of moist, gentle and agreeable, glossy hair.
Drawings
FIGS. 1-4 are graphs showing the results of testing wet/dry combing performance of hair in examples of the present application;
fig. 5-6 are scanning electron microscope pictures of hair fibers after rinsing in the examples of the present application.
Detailed Description
In order that those skilled in the art will better understand the technical solution of the present invention, the present invention will be further described in detail with reference to the following embodiments;
example 1: a shampoo composition with softening and repairing effects comprises 0.2g of acrylamide propyl trimethyl ammonium chloride/acrylamide copolymer, 100.1 g of polyquaternium, 2g of PEG-75 shea butter glyceride, 1g of keratin and hydrolyzed keratin and 0.5g of myristamide propane dimethyl ammonium chloride phosphate.
The preparation method of the shampoo composition with softening and repairing effects comprises the following specific preparation steps:
(1) weighing acrylamide propyl trimethyl ammonium chloride/acrylamide copolymer, polyquaternary ammonium salt-10, PEG-75 shea butter glyceride, keratin, hydrolyzed keratin and myristamide propyl dimethyl ammonium chloride phosphate as raw materials according to the formula amount;
(2) uniformly mixing acrylamide propyl trimethyl ammonium chloride/acrylamide copolymer, polyquaternary ammonium salt-10, PEG-75 shea butter glyceride, keratin, hydrolyzed keratin and myristamide propyl dimethyl ammonium chloride phosphate to obtain the final product.
Example 2: a shampoo composition with softening and repairing effects comprises the effective components of acrylamide propyl trimethyl ammonium chloride/acrylamide copolymer, polyquaternium-10, PEG-75 shea butter glyceride, keratin and hydrolyzed keratin, and myristamide propane dimethyl ammonium chloride phosphate, wherein the acrylamide propyl trimethyl ammonium chloride/acrylamide copolymer is 0.1g, the polyquaternium is-100.1 g, the PEG-75 shea butter glyceride is 1g, the keratin and hydrolyzed keratin are 2g, and the myristamide propane dimethyl ammonium chloride phosphate is 1 g. The preparation method is the same as example 1.
Example 3: a shampoo composition with softening and repairing effects comprises the effective components of acrylamide propyl trimethyl ammonium chloride/acrylamide copolymer, polyquaternium-10, PEG-75 shea butter glyceride, keratin and hydrolyzed keratin, and myristamide propane dimethyl ammonium chloride phosphate, wherein the acrylamide propyl trimethyl ammonium chloride/acrylamide copolymer is 0.1g, the polyquaternium-100.1 g, the PEG-75 shea butter glyceride is 2g, the keratin and hydrolyzed keratin are 1g, and the myristamide propane dimethyl ammonium chloride phosphate is 1 g.
The function of the compositions described in the examples was determined.
Conditioning Performance test
(1) Control group: experimental example 1 shampoo prepared after removing shampoo composition;
(2) test group 1: experimental example 1 shampoo prepared without adding polyquaternium-10;
(3) test group 2: experimental example 1 shampoo prepared without addition of keratin and hydrolyzed keratin;
(4) test group 3: shampoo prepared in experimental example 1;
(5) test group 4: shampoo prepared in experimental example 2;
(6) test group 5: shampoo prepared in experimental example 3;
wet comb test method: prepare 4 locks of hair, massage the hair from root to tip for 1 minute with control product, test product 1, test product 2, test product 3, respectively, and rinse in tap water for 2 minutes to avoid knotting of the hair. 800ml of deionized water was prepared, added to a beaker, the hair was immersed in water 3 times, excess water was removed from the root to the tip of the hair, and wet combing performance was tested with a tensile tester. Repeat 5-8 times, collect data. The maximum carding force F1 and the total carding work W1 are obtained by washing the control product, and the maximum carding force Fx and the total carding work Wx are obtained by washing the test product according to the following calculation formulas:
the maximum value of the combing force is reduced,
the total work is reduced and the total work is reduced,
dry comb test method: prepare 4 locks of hair, massage the hair from root to tip for 1 minute with control product, test product 1, test product 2, test product 3, respectively, and rinse in tap water for 2 minutes to avoid knotting of the hair. The carding performance was tested by drying at 23 ℃ and 65% relative humidity for 12 hours. The maximum carding force F2 and the total carding work W2 are obtained by washing the control product, and the maximum carding force Fy and the total carding work Wy are obtained by washing the test product according to the calculation formulas:
the maximum value of the combing force is reduced,
the total work is reduced and the total work is reduced,
wherein, fig. 1 shows the results of the test of the wet combing performance of hair (in percent reduction) of the control product and the test product. Figure 2 is the results (in percent reduction) of the control and test products for hair drying performance.
According to the results of the conditioning test, it was found that the shampoo of experimental example 1 can significantly improve the anti-tangling property and conditioning property of the hair, and make the hair smoother.
To further verify the effect of different addition levels of shampoo compositions on wet combing and dry combing conditioning performance of hair, the following tests were designed: the shampoo prepared in experimental example 1 was prepared by adding shampoo compositions in amounts of 2 parts, 4 parts, 6 parts, 8 parts and 10 parts, respectively, and the test results (in terms of percentage reduction) were shown in fig. 3 and 4, which were measured according to the wet combing and dry combing test methods described above.
According to the test results, the following results are obtained: the wet combing and dry combing performance of the hair was gradually enhanced as the added amount of the shampoo composition was increased, and the formulation of the shampoo prepared in experimental example 1 (6 points of addition of the shampoo composition) was selected as the final formulation of the product in consideration of the efficacy test results of the added shampoo composition and the cost problems in real life.
Protection experiment of hair scale
(1) Control group: experimental example 1 shampoo prepared after removing shampoo composition
(2) Test group: shampoo prepared in Experimental example 1
Prepare 2 locks of hair, massage the hair from root to tip for 1 minute with the control product and the test product, respectively, and rinse in tap water for 2 minutes to avoid knotting of the hair. After drying at 23 ℃ and a relative humidity of 65% for 12 hours, the integrity of the hair scales of both locks was observed by means of an electron microscope. Wherein fig. 5 is a scanning electron microscope picture of hair fibers after washing with the control product and fig. 6 is a scanning electron microscope picture of hair fibers after washing with the test product.
From the results of the microscopic pictures of FIGS. 5 to 6, it can be seen that the hair washed with the control product had slight marks of lifting and breaking of hair scales, while the hair washed with the test product had relatively intact hair fibers with a film adhered closely to the surface, thereby making the hair fibers look smooth.
A method of preparing a shampoo using the shampoo composition having a softening and revitalizing effect described in example 1, the shampoo composition is shown in Table 1. The preparation steps are as follows:
adding the raw materials in the phase A into a reaction kettle, starting stirring, adjusting the revolution of a scraper stirrer to 60 revolutions per minute, starting a heating switch, controlling the temperature to be 70-80 ℃, stirring until the raw materials are completely dissolved, and then cooling. Cooling to 45-55 deg.C, adding B phase raw material, stirring for 30 min, stopping stirring, breaking vacuum, sampling, testing, and discharging. Standing for 24 hours, and filling when the temperature is lower than 38 ℃. The components of the shampoo are shown in table 1.
TABLE 1
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the invention.
Claims (6)
1. A silicone oil-free shampoo composition with softening and repairing effects is characterized by comprising the following components in parts by mass: 0.1-0.5 part of acrylamide propyl trimethyl ammonium chloride/acrylamide copolymer, 100.1-0.5 part of polyquaternium, 1-5 parts of PEG-75 shea butter glyceride, 1-5 parts of keratin and hydrolyzed keratin, and 0.5-2 parts of myristamide propyl dimethyl ammonium chloride phosphate.
2. The silicone-free hair shampoo composition with softening and repairing efficacy according to claim 1, characterized in that: comprises the following components in parts by mass: 0.2 part of acrylamide propyl trimethyl ammonium chloride/acrylamide copolymer, 100.1 parts of polyquaternary ammonium salt, 2 parts of PEG-75 shea butter glyceride, 1 part of keratin and hydrolyzed keratin and 0.5 part of myristamide propyl dimethyl ammonium chloride phosphate.
3. A method of preparing a silicone-free hair shampoo composition with softening and repairing effects as claimed in claim 1 or 2, characterized in that: the preparation method comprises the following specific steps:
(1) weighing acrylamide propyl trimethyl ammonium chloride/acrylamide copolymer, polyquaternary ammonium salt-10, PEG-75 shea butter glyceride, keratin, hydrolyzed keratin and myristamide propyl dimethyl ammonium chloride phosphate as raw materials according to the formula amount;
(2) uniformly mixing acrylamide propyl trimethyl ammonium chloride/acrylamide copolymer, polyquaternary ammonium salt-10, PEG-75 shea butter glyceride, keratin, hydrolyzed keratin and myristamide propyl dimethyl ammonium chloride phosphate to obtain the final product.
4. Use of the silicone oil-free shampoo composition with softening and repairing effects according to any one of claims 1-2 in a shampoo; the shampoo composition has a content of 4-15 wt% in the shampoo.
5. Use of a silicone-free hair shampoo composition with softening and repairing effect according to claim 4, characterized in that: the shampoo is prepared by the following method:
(1) weighing deionized water, a surfactant, a chelating agent and a thickening agent, adding the deionized water, the surfactant, the chelating agent and the thickening agent into a reaction kettle, starting stirring, adjusting the revolution of a scraper stirrer to 60 revolutions per minute, starting a heating switch, controlling the temperature to be 70-80 ℃, stirring until the raw materials are completely dissolved, and then cooling;
(2) cooling to 45-55 deg.C, adding the shampoo composition, essence, antiseptic, and pH regulator, stirring, breaking vacuum, sampling, testing, and discharging;
(3) standing for 24 hours, and filling when the temperature is lower than 38 ℃.
6. Use of a shampoo composition with softening and repairing effect according to claim 5, characterized in that: the surfactant is one or any combination of sodium cocoyl methyl taurate, sodium cocoamido propionate, sodium cocoyl glycinate, sodium lauroyl sarcosinate, sodium lauroyl amphoacetate, cocamidopropyl betaine, lauryl hydroxy sulfobetaine and decyl glucoside, the dosage is 5-30%, and the chelating agent is disodium EDTA, the dosage is 0.1%; the thickener is one or any combination of PEG-120 methyl glucose dioleate, distearyl polyether-5 lauroyl glutamate, cocamide MEA, cocamide methyl MEA, and C12-15 alcohol lactate, and the use amount is 1% -5%; the amount of the essence is 0.2-0.5%; the preservative is one or any combination of anisic acid, phenoxyethanol, methyl paraben and sodium benzoate, and the dosage of the preservative is 0.3-0.9%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011351988.8A CN112402301A (en) | 2020-11-27 | 2020-11-27 | Silicone-oil-free shampoo composition with softening and repairing effects and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011351988.8A CN112402301A (en) | 2020-11-27 | 2020-11-27 | Silicone-oil-free shampoo composition with softening and repairing effects and preparation method and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112402301A true CN112402301A (en) | 2021-02-26 |
Family
ID=74843617
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011351988.8A Pending CN112402301A (en) | 2020-11-27 | 2020-11-27 | Silicone-oil-free shampoo composition with softening and repairing effects and preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN112402301A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115569082A (en) * | 2022-09-22 | 2023-01-06 | 羽楠(广州)化妆品有限公司 | Hair conditioning composition with repairing effect and preparation method and application thereof |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002083073A2 (en) * | 2001-04-16 | 2002-10-24 | Wsp Chemical & Technology Llc | Cosmetic compositions containing water-soluble polymer complexes |
| EP1880712A2 (en) * | 2006-06-28 | 2008-01-23 | Beiersdorf Aktiengesellschaft | Hair cleaning compounds with special sensor capability |
| CN104224575A (en) * | 2014-09-12 | 2014-12-24 | 广州市天吻娇颜化妆品有限公司 | Transparent silicone-oil-free hairdressing composition and preparation method thereof |
| CN104921989A (en) * | 2015-06-12 | 2015-09-23 | 广州环亚化妆品科技有限公司 | Liquid shampoo without silicon oil and with hair caring effect and preparation method thereof |
| CN106265167A (en) * | 2016-09-30 | 2017-01-04 | 广州赛莱拉干细胞科技股份有限公司 | A kind of compositions and shampoo and preparation method thereof |
| CN106265169A (en) * | 2016-10-12 | 2017-01-04 | 广州丹奇日用化工厂有限公司 | A kind of without silicone oil shampoo |
| CN106361660A (en) * | 2016-10-14 | 2017-02-01 | 广州澳希亚实业有限公司 | Sulfate-anionic-surfactant-free silicone-oil-free shampoo composition |
| CN107198663A (en) * | 2017-05-12 | 2017-09-26 | 广州市蔻妍化妆品有限公司 | It is a kind of without silicone oil baby hair washing, two-in-one composition and preparation method thereof of taking a shower |
| CN110934783A (en) * | 2018-09-21 | 2020-03-31 | 珠海伊斯佳科技股份有限公司 | Dandruff-removing and itching-relieving composition containing Chinese herbal medicines, silicone oil-free amino acid shampoo containing composition, and preparation method and application of silicone oil-free amino acid shampoo |
-
2020
- 2020-11-27 CN CN202011351988.8A patent/CN112402301A/en active Pending
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002083073A2 (en) * | 2001-04-16 | 2002-10-24 | Wsp Chemical & Technology Llc | Cosmetic compositions containing water-soluble polymer complexes |
| EP1880712A2 (en) * | 2006-06-28 | 2008-01-23 | Beiersdorf Aktiengesellschaft | Hair cleaning compounds with special sensor capability |
| CN104224575A (en) * | 2014-09-12 | 2014-12-24 | 广州市天吻娇颜化妆品有限公司 | Transparent silicone-oil-free hairdressing composition and preparation method thereof |
| CN104921989A (en) * | 2015-06-12 | 2015-09-23 | 广州环亚化妆品科技有限公司 | Liquid shampoo without silicon oil and with hair caring effect and preparation method thereof |
| CN106265167A (en) * | 2016-09-30 | 2017-01-04 | 广州赛莱拉干细胞科技股份有限公司 | A kind of compositions and shampoo and preparation method thereof |
| CN106265169A (en) * | 2016-10-12 | 2017-01-04 | 广州丹奇日用化工厂有限公司 | A kind of without silicone oil shampoo |
| CN106361660A (en) * | 2016-10-14 | 2017-02-01 | 广州澳希亚实业有限公司 | Sulfate-anionic-surfactant-free silicone-oil-free shampoo composition |
| CN107198663A (en) * | 2017-05-12 | 2017-09-26 | 广州市蔻妍化妆品有限公司 | It is a kind of without silicone oil baby hair washing, two-in-one composition and preparation method thereof of taking a shower |
| CN110934783A (en) * | 2018-09-21 | 2020-03-31 | 珠海伊斯佳科技股份有限公司 | Dandruff-removing and itching-relieving composition containing Chinese herbal medicines, silicone oil-free amino acid shampoo containing composition, and preparation method and application of silicone oil-free amino acid shampoo |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115569082A (en) * | 2022-09-22 | 2023-01-06 | 羽楠(广州)化妆品有限公司 | Hair conditioning composition with repairing effect and preparation method and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR102088916B1 (en) | Hair beauty composition comprising silicone and surfactant, and beauty treatment method | |
| US20140094423A1 (en) | Aqueous hair cleansing agent | |
| CN104856895B (en) | A kind of without silicon shampoo and preparation method thereof | |
| EP3344344B1 (en) | Composition comprising an anionic-ampholytic polymer association | |
| US20190070084A1 (en) | Hair treatment agent with a polyvalent cation ii | |
| US20220183958A1 (en) | Rhamnolipids as deposition aid | |
| EP2939659B1 (en) | Hair cleansing composition | |
| CN112402301A (en) | Silicone-oil-free shampoo composition with softening and repairing effects and preparation method and application thereof | |
| EP3439623B1 (en) | Compositions with acylisethionate surfactant and methods of use | |
| EP3171942A1 (en) | Hair conditioning compositions | |
| WO2019096517A1 (en) | A transparent hair conditioning composition and its use | |
| CN114767576A (en) | Softening amino acid shampoo and preparation method thereof | |
| US11896703B2 (en) | Liquid lipid composite composition for improving hair condition | |
| JP2584260B2 (en) | Agent for permanent wave | |
| JP7294642B2 (en) | hair cosmetics | |
| US11523977B2 (en) | Multi-agent type hair treatment agent | |
| FR3072569A1 (en) | CAPILLARY TREATMENT AGENT STRENGTHENING THE STRUCTURE WITH INCREASED CARING EFFECT | |
| JP2001335437A (en) | Hair treatment | |
| EA041480B1 (en) | COMPOSITION FOR HAIR CONDITIONING FOR IMPROVING RINSEABILITY | |
| JP2000281539A (en) | Cosmetic base | |
| CN116887807A (en) | Hair conditioning formulation | |
| CN117243830A (en) | Hair cleansing composition and use thereof | |
| EA040884B1 (en) | HAIR COMPOSITION HAVING IMPROVED RINSE PERFORMANCE | |
| WO2023070507A1 (en) | Transparent composition for cleansing and conditioning the hair | |
| WO2019115156A1 (en) | A hair cleansing composition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20210226 |