CN112393960A - Sample pretreatment device and sample pretreatment method using same - Google Patents
Sample pretreatment device and sample pretreatment method using same Download PDFInfo
- Publication number
- CN112393960A CN112393960A CN202011230313.8A CN202011230313A CN112393960A CN 112393960 A CN112393960 A CN 112393960A CN 202011230313 A CN202011230313 A CN 202011230313A CN 112393960 A CN112393960 A CN 112393960A
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- reaction tube
- sample pretreatment
- sample
- tube
- reagent
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/38—Diluting, dispersing or mixing samples
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/38—Diluting, dispersing or mixing samples
- G01N2001/386—Other diluting or mixing processes
Abstract
The application relates to a sample pretreatment device, it includes reaction tube and reagent pipe, wherein is provided with the reaction chamber in this reaction tube, and this sample tube one end can be dismantled with the tubulose lid and be connected, and the other end cup joints and sets up in the reagent intraductally, is provided with the reagent chamber in this reagent pipe, and the one end of this reagent pipe is used for holding reaction tube, the other end are provided with the notes liquid mouth that is used for the output material, just it is provided with the sealing member that can impale on the route of liquid mouth and external environment fluid intercommunication to annotate, wherein the lid is kept away from including the bellied face the arc top of reaction tube. The beneficial effects of this application lie in this paper sample pretreatment device's lid in be provided with the arc top, and the reaction tube sleeve establishes within the reagent pipe, when utilizing this sample pretreatment device to carry out sample pretreatment, can carry out the high-efficient mixture that the supersound realized the material through upset sample pretreatment device, reduce artificial intervention as far as simultaneously, avoid polluting.
Description
Technical Field
The invention relates to the technical field of reaction equipment, in particular to a sample pretreatment device and a sample pretreatment method using the same.
Background
In addition to the fields of chemical and life engineering, fluid sample analysis is widely used in the diagnostic field of analyzing blood, body fluid taken from a patient for diagnosis, and the like, particularly in the fields of extraction, purification, and detection of nucleic acids.
One key in the method of analyzing a fluid sample is the pre-treatment of the fluid sample. The pretreatment of a fluid sample means that a desired amount of the sample is extracted before the fluid sample is analyzed, and the sample is precisely treated with, for example, a dilution buffer or a lysis solution at an appropriate ratio, or mixed with a reaction reagent in a solid or liquid state, or separated and purified by a packing or a support.
The devices currently used for the pre-treatment of fluid samples are difficult to perform continuous manipulation, opening and closing manipulations, and some require even manual biochemical treatments. Since a biological material-based fluid sample to be processed may often contain infectious agents, human intervention during sample pre-processing should be minimized.
In addition, it is generally difficult to achieve efficient mixing of samples in conventional fluid sample pretreatment apparatuses, and it is necessary to separate and transfer samples by centrifugation or the like after performing a reaction.
Therefore, there is a continuing need in the art to develop a sample pretreatment device with less manual intervention and good mixing effect.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provide a sample pretreatment device with less manual intervention and good mixing effect.
The present application also provides a sample pretreatment method using the sample pretreatment apparatus.
In order to achieve the object of the present invention, the present application provides the following technical solutions.
In a first aspect, the present application provides a sample pretreatment apparatus, comprising:
the reaction tube is internally provided with a reaction cavity, one end of the sample tube is detachably connected with the tubular cover body, and the other end of the sample tube is sleeved in the reagent tube; and
the reagent tube is internally provided with a reagent cavity, one end of the reagent tube is used for accommodating the reaction tube, the other end of the reagent tube is provided with a liquid injection port for outputting materials, and a pierceable sealing piece is arranged on a path for fluid communication between the liquid injection port and the external environment;
wherein the reaction tube has an outer diameter smaller than an inner diameter of the reagent tube, and is configured to be movable in a longitudinal axis direction of the reagent tube;
wherein the reaction chamber and the reagent chamber are in fluid communication;
wherein the cover body comprises an arc-shaped top part with a convex surface far away from the reaction tube.
In one embodiment of the first aspect, a filter device is provided in a path through which the liquid inlet and the reagent chamber are in fluid communication.
In one embodiment of the first aspect, the cover further comprises at least two cover locking members disposed at the outer periphery of the arc-shaped top, each cover locking member extending a predetermined length away from the reaction tube and comprising an L-shaped platform opening away from the outer periphery of the arc-shaped top;
wherein the periphery of the end part of the reaction tube connected with the cover body is provided with at least two reaction tube clamping parts, and the at least two reaction tube clamping parts extend for a preset length towards the direction far away from the reaction tube and comprise convex parts towards the peripheral direction of the reaction tube;
wherein the L-shaped platform of the cover body clamping part is constructed to be suitable for being fixed with the protruding part of the reaction tube clamping part through clamping.
In one embodiment of the first aspect, the cover comprises 4 cover engaging members uniformly disposed along the outer periphery of the arc-shaped top;
and 4 reaction tube clamping parts are uniformly arranged on the periphery of the end part of the reaction tube connected with the cover body.
In one embodiment of the first aspect, the sample pretreatment apparatus further includes a lid seal disposed between an annular gap formed when the lid is connected to the reaction tube.
In one embodiment of the first aspect, the outer periphery of the reaction tube is provided with an annular convex portion having an outer diameter greater than or equal to the inner diameter of the reagent tube.
In one embodiment of the first aspect, the sample pretreatment apparatus further includes a reaction tube sealing member disposed between an annular gap formed when the reaction tube is connected to the reagent tube and between the annular protrusion portion and the end portion of the reagent tube where the liquid injection port is provided.
In one embodiment of the first aspect, the reagent vessel includes a tapered portion having a diameter gradually decreasing toward the pouring port at an end thereof provided with the pouring port.
In one embodiment of the first aspect, the sample pretreatment device further includes a protective sleeve detachably fixed to the periphery of the liquid injection port.
In one embodiment of the first aspect, the sample pretreatment apparatus further includes a liquid injection port sealing member provided between an annular gap formed between the liquid injection port and the protective cover.
In a second aspect, the present application provides a sample pretreatment method using the sample pretreatment apparatus according to the first aspect, the method comprising:
(1) opening the cover body, adding a sample to be pretreated into the reaction cavity, and then fixing the cover body to the reaction tube in an airtight manner;
(2) and turning over the sample pretreatment device for adding the sample to be pretreated, enabling the cover body to be arranged below the reaction tube, and carrying out ultrasonic treatment on the sample pretreatment device to obtain the pretreated sample.
In one embodiment of the second aspect, the method further comprises the steps of:
(3) after the sample pretreatment apparatus is subjected to the ultrasonic treatment, the sample pretreatment apparatus is turned over, the lid body is placed above the reaction tube, a pierceable seal provided in a path through which the liquid injection port is in fluid communication with the external environment is pierced, and the pretreated sample is output.
Compared with the prior art, the cover body of the sample pretreatment device has the beneficial effects that the arc-shaped top is arranged in the cover body, the reaction tube is sleeved in the reagent tube, and when the sample pretreatment device is used for sample pretreatment, the sample pretreatment device can be turned over to carry out ultrasonic mixing to realize high-efficiency mixing of materials, so that manual intervention is reduced as much as possible, and pollution is avoided.
Drawings
Fig. 1 is a perspective view of a sample pretreatment apparatus according to an embodiment of the present invention.
Fig. 2 is a cross-sectional view of a sample pretreatment device according to an embodiment of the present invention in a sample application state.
Fig. 3 is a schematic view of a cover of a sample pretreatment apparatus according to an embodiment of the present invention.
Fig. 4 is a plan view of a cover of the sample pretreatment apparatus according to an embodiment of the present invention.
Fig. 5 is a bottom view of a cover of the sample pretreatment apparatus according to an embodiment of the present invention.
Fig. 6 is a front view of a sample pretreatment apparatus according to an embodiment of the present invention in a sample treatment state.
Fig. 7 is a sectional view of a sample pretreatment apparatus according to an embodiment of the present invention in a sample treatment state.
Fig. 8 is a sectional view of a sample preprocessing device according to an embodiment of the present invention in a sample transfer state.
Fig. 9 is a front view of the sample preprocessing device according to the embodiment of the present invention in the sample transfer state.
In the above drawings, the reference numerals have the following meanings:
100 sample pretreatment device
10 cover body
101 arc top
102 cover body clamping component
103 cover seal
20 reaction tube
201 reaction chamber
202 reaction tube clamping part
203 annular raised portion
204 reaction tube sealing element
30 reagent tube
301 reagent chamber
302 filter device
303 liquid filling port
304 pierceable seal
305 liquid filling port sealing member
40 protective sheath.
Detailed Description
Unless otherwise defined, technical or scientific terms used herein in the specification and claims should have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. All numerical values recited herein as between the lowest value and the highest value are intended to mean all values between the lowest value and the highest value in increments of one unit when there is more than two units difference between the lowest value and the highest value. In the description of the present invention, it is to be understood that the terms "central," "longitudinal," "lateral," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like are used in the orientation or positional relationship indicated in the drawings, which are merely for convenience in describing the invention and to simplify the description, and are not intended to indicate or imply that the referenced device or element must have a particular orientation, be constructed and operated in a particular orientation, and are therefore not to be construed as limiting the invention. Furthermore, the terms "first", "second", etc. are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first," "second," etc. may explicitly or implicitly include one or more of that feature. In the description of the invention, the meaning of "a plurality" is two or more unless otherwise specified.
In the description of the invention, it is to be noted that, unless otherwise explicitly specified or limited, the terms "mounted", "connected" and "connected" are to be construed broadly, e.g. as being fixed or detachable or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the creation of the present invention can be understood by those of ordinary skill in the art through specific situations.
In the following detailed description of the embodiments of the present invention, reference is made to the accompanying drawings, where it is noted that in the interest of brevity and conciseness, not all features of an actual embodiment may be described in detail in this specification. Modifications and substitutions to the embodiments of the present invention may be made by those skilled in the art without departing from the spirit and scope of the present invention, and the resulting embodiments are within the scope of the present invention.
Referring first to fig. 1 and 6, in one embodiment, the present application provides a sample pre-processing apparatus 100. In the embodiment shown in fig. 1 and 6, the sample pretreatment apparatus 100 includes a tubular cover 10, a reaction tube 20, a reagent tube 30, and an optional protective cover 40 in this order. Herein, the cap body 10 may be detachably coupled to one end of the reaction tube 20. The other end of the reaction tube 20 can be sleeved in the reagent tube.
Referring next to fig. 2, a reaction chamber 201 may be disposed in the reaction tube 20, and the reaction chamber 201 may be used for pre-processing a sample. The reagent tube 30 may be provided therein with a reagent chamber 301, one end of the reagent tube 30 is used for accommodating the reaction tube 20, the other end is provided with an injection port 303 for outputting the material, and a pierceable sealing member 304 is disposed on a path of the injection port 303 in fluid communication with the external environment. In one embodiment, a filter 302 is optionally disposed on the path of the liquid injection port 303 in fluid communication with the reagent chamber 301. In one embodiment, the filter apparatus 302 may be a filter membrane and the pierceable seal 304 may be a sealing membrane. In this embodiment, in order to allow the reaction tube 20 to be sleeved inside the reagent tube 30, the outer diameter of the reaction tube 20 is smaller than the inner diameter of the reagent tube 30, and the reaction tube 20 is configured to be movable along the longitudinal axis direction of the reagent tube 30. In order to improve the efficiency of sample pretreatment, the reaction chamber 201 and the reagent chamber 301 are in fluid communication, and the cover 10 includes an arc-shaped top 101 having a convex surface away from the reaction tube 20.
As described above, herein, the cover 10 may be detachably coupled to the reaction tube 20. For example, the cover 10 may be detachably coupled to the reaction tube 20 by means of a snap-fit or screw-coupling. Referring to fig. 2 to 5, the cover 10 described herein may include at least two cover catching members 102, the at least two cover catching members 102 being disposed at the arc-shaped top periphery, each cover catching member 102 extending a predetermined length in a direction away from the reaction tube and including an L-shaped platform opening away from the arc-shaped top periphery. Accordingly, the outer circumference of the end of the reaction tube 20 connected to the cap body 10 may be provided with at least two reaction tube catching parts 202, the at least two reaction tube catching parts 202 extending a predetermined length in a direction away from the reaction tube 20 and including a convex portion in a direction toward the outer circumference of the reaction tube. In this embodiment, the L-shaped platform of the cover latch member 102 is configured to be secured by latching with the raised portion of the reaction tube latch member 202. In a preferred embodiment, the cover 10 may include 4 cover snap members 102 evenly disposed along the outer periphery of the arc-shaped top portion. In a preferred embodiment, the outer circumference of the end of the reaction tube 20 connected to the cover may be uniformly provided with 4 reaction tube engaging parts 202. In another embodiment, in order to improve the sealing property, the sample pretreatment apparatus 100 further includes a cap seal 103 disposed between an annular gap formed when the cap 10 is coupled to the reaction tube 20.
Returning to FIG. 2, in one embodiment, the outer periphery of the reaction tube 20 is provided with an annular raised portion 202, and the outer diameter of the annular raised portion 202 is greater than or equal to the inner diameter of the reagent tube 30, so that an interference fit can be formed with the inner wall of the reagent tube 30. In order to further improve the sealing performance of the reaction chamber 201 and the reagent chamber 301, the sample pre-treatment apparatus 100 described herein may further include a reaction tube sealing member 203. The reaction tube sealing member 203 is provided between the annular gap formed when the reaction tube 20 and the reagent tube 30 are connected, and between the annular projecting portion 202 and the end portion of the reagent tube 30 where the liquid inlet 303 is provided.
Still referring to FIG. 2, in one embodiment, the end of the reagent vessel 30 provided with the pouring outlet 303 includes a tapered portion that gradually decreases in diameter toward the pouring outlet. In one embodiment, the pour spout 303 may be a tubular hollow channel extending a length, one end of which is connected to the bottom of the conical portion and one end of which may be in fluid communication with the external environment. The filter means 302 may be provided where the conical portion connects to the pouring spout 303 and the pierceable seal 304 may be provided where the pouring spout 303 communicates with the external environment.
Referring again to fig. 2, in order to prevent the sample from being contaminated during the processing, the sample preprocessing device 100 described herein may further include a protective cover 40, and the protective cover 40 may be detachably fixed to the periphery of the liquid injection port 303. In order to ensure the sealing between the reagent chamber 301 and the reaction chamber 201, the sample pretreatment apparatus 100 further includes a liquid inlet seal 305, and the liquid inlet seal 305 is provided between the liquid inlet 303 and the annular gap formed by the protective cover 40.
A sample pretreatment method using the sample pretreatment apparatus described herein will be described below with reference to the drawings. In general, the sample pre-processing apparatus 100 described herein can include three stages, a sample loading stage, a sample processing stage, and a sample transfer stage, when in use. Referring to fig. 2, when sample is added, the cover 10 and the reaction tube 20 are separated, and then a sample to be pretreated is added to the reaction chamber. After the sample addition is completed, the lid 10 needs to be fixed to the reaction tube 20 in an airtight manner.
In the sample processing stage, referring to fig. 6 and 7, the sample pre-processing apparatus 100 to be pre-processed sample can be turned over, so that the cover 10 is under the reaction tube 20, and the sample pre-processing apparatus 100 is subjected to ultrasound, so as to obtain the pre-processed sample. In this step, the arcuate top of the cover 10 may concentrate ultrasonic energy, enhancing sample pre-processing efficiency in the sample pre-processing apparatus 10.
In the sample transfer stage, referring to fig. 8, the sample pretreatment apparatus 100 may be turned over again so that the lid 10 is above the reaction tube 20 and the pierceable seal 304 provided in the path through which the liquid inlet and the external environment are in fluid communication is pierced, thereby outputting the pretreated sample. Preferably, the reaction tube 20 may be slid downward relative to the reagent tube 30 during the sample transfer stage. Along with the compression of space, the pressure in the reagent pipe increases, and sample liquid flows out from annotating the liquid mouth under the effect of pressure.
As shown in fig. 9, in the embodiment where the sample preprocessing device 100 includes the protection cover 40, the protection cover 40 may be removed first, and then the preprocessed sample may be output.
In one embodiment, a sample pre-treatment method using the sample pre-treatment apparatus described herein may comprise the steps of:
(1) opening the cover body, adding a sample to be pretreated into the reaction cavity, and then fixing the cover body to the reaction tube in an airtight manner;
(2) turning over a sample pretreatment device for adding a sample to be pretreated, enabling the cover body to be arranged below the reaction tube, and carrying out ultrasonic treatment on the sample pretreatment device to obtain a pretreated sample;
(3) after the sample pretreatment apparatus is subjected to the ultrasonic treatment, the sample pretreatment apparatus is turned over, the lid body is placed above the reaction tube, a pierceable seal provided in a path through which the liquid injection port is in fluid communication with the external environment is pierced, and the pretreated sample is output.
The embodiments described above are intended to facilitate the understanding and appreciation of the application by those skilled in the art. It will be readily apparent to those skilled in the art that various modifications to these embodiments may be made, and the generic principles described herein may be applied to other embodiments without the use of the inventive faculty. Therefore, the present application is not limited to the embodiments herein, and those skilled in the art who have the benefit of this disclosure will appreciate that many modifications and variations are possible within the scope of the present application without departing from the scope and spirit of the present application.
Claims (11)
1. A sample pretreatment device is characterized by comprising:
the reaction tube is internally provided with a reaction cavity, one end of the sample tube is detachably connected with the tubular cover body, and the other end of the sample tube is sleeved in the reagent tube; and
the reagent tube is internally provided with a reagent cavity, one end of the reagent tube is used for accommodating the reaction tube, the other end of the reagent tube is provided with a liquid injection port for outputting materials, and a pierceable sealing piece is arranged on a path for fluid communication between the liquid injection port and the external environment;
wherein the reaction tube has an outer diameter smaller than an inner diameter of the reagent tube, and is configured to be movable in a longitudinal axis direction of the reagent tube;
wherein the reaction chamber and the reagent chamber are in fluid communication;
wherein the cover body comprises an arc-shaped top part with a convex surface far away from the reaction tube.
2. The sample pretreatment apparatus of claim 1, wherein the cover further comprises at least two cover engagement members disposed at the outer periphery of the arc-shaped top, each cover engagement member extending a predetermined length in a direction away from the reaction tube and comprising an L-shaped platform opening away from the outer periphery of the arc-shaped top;
wherein the periphery of the end part of the reaction tube connected with the cover body is provided with at least two reaction tube clamping parts, and the at least two reaction tube clamping parts extend for a preset length towards the direction far away from the reaction tube and comprise convex parts towards the peripheral direction of the reaction tube;
wherein the L-shaped platform of the cover body clamping part is constructed to be suitable for being fixed with the protruding part of the reaction tube clamping part through clamping.
3. The sample pretreatment apparatus of claim 2, wherein the cover includes 4 cover snap-fit members evenly disposed along an outer periphery of the arc-shaped top;
and 4 reaction tube clamping parts are uniformly arranged on the periphery of the end part of the reaction tube connected with the cover body.
4. The sample pretreatment apparatus according to claim 1, further comprising a cover sealing member provided between an annular gap formed when the cover is connected to the reaction tube.
5. The sample pretreatment apparatus according to claim 1, wherein an outer periphery of the reaction tube is provided with an annular convex portion having an outer diameter equal to or larger than an inner diameter of the reagent tube.
6. The sample pretreatment apparatus according to claim 5, further comprising a reaction tube sealing member provided between an annular gap formed when the reaction tube is connected to the reagent tube and between the annular projecting portion and an end portion of the reagent tube provided with the liquid inlet.
7. The sample pretreatment apparatus according to any one of claims 1 to 6, wherein an end of the reagent vessel provided with the liquid inlet includes a tapered portion having a diameter gradually decreasing toward the liquid inlet.
8. The sample pretreatment device according to any one of claims 1 to 6, further comprising a protective cover detachably fixed to a periphery of the liquid inlet.
9. The sample pretreatment apparatus according to claim 8, further comprising a liquid pouring port sealing member provided between an annular gap formed between the liquid pouring port and the protective cover.
10. A sample pretreatment method using the sample pretreatment apparatus according to any one of claims 1 to 9, characterized by comprising:
(1) opening the cover body, adding a sample to be pretreated into the reaction cavity, and then fixing the cover body to the reaction tube in an airtight manner;
(2) and turning over the sample pretreatment device for adding the sample to be pretreated, enabling the cover body to be arranged below the reaction tube, and carrying out ultrasonic treatment on the sample pretreatment device to obtain the pretreated sample.
11. The method of claim 10, further comprising the steps of:
(3) after the sample pretreatment apparatus is subjected to the ultrasonic treatment, the sample pretreatment apparatus is turned over, the lid body is placed above the reaction tube, a pierceable seal provided in a path through which the liquid injection port is in fluid communication with the external environment is pierced, and the pretreated sample is output.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011230313.8A CN112393960A (en) | 2020-11-06 | 2020-11-06 | Sample pretreatment device and sample pretreatment method using same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011230313.8A CN112393960A (en) | 2020-11-06 | 2020-11-06 | Sample pretreatment device and sample pretreatment method using same |
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| CN112393960A true CN112393960A (en) | 2021-02-23 |
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| CN202011230313.8A Pending CN112393960A (en) | 2020-11-06 | 2020-11-06 | Sample pretreatment device and sample pretreatment method using same |
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| CN203606330U (en) * | 2013-12-13 | 2014-05-21 | 中国人民解放军海军医学研究所 | Test tube and kit for pretreatment of blood sample |
| US20170219462A1 (en) * | 2014-07-24 | 2017-08-03 | Noble House Group Pty. Ltd. | Segment Sampler |
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