CN205856451U - A kind of sample processing device - Google Patents
A kind of sample processing device Download PDFInfo
- Publication number
- CN205856451U CN205856451U CN201620763138.1U CN201620763138U CN205856451U CN 205856451 U CN205856451 U CN 205856451U CN 201620763138 U CN201620763138 U CN 201620763138U CN 205856451 U CN205856451 U CN 205856451U
- Authority
- CN
- China
- Prior art keywords
- pipe
- next door
- adsorption tube
- sample cell
- cavity volume
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000001179 sorption measurement Methods 0.000 claims abstract description 42
- 238000010521 absorption reaction Methods 0.000 claims abstract description 28
- 238000009434 installation Methods 0.000 claims description 9
- 238000005452 bending Methods 0.000 claims description 6
- 239000004793 Polystyrene Substances 0.000 claims description 3
- 229920000573 polyethylene Polymers 0.000 claims description 3
- 229920002223 polystyrene Polymers 0.000 claims description 3
- 239000004698 Polyethylene Substances 0.000 claims description 2
- -1 polyethylene Polymers 0.000 claims description 2
- 238000001914 filtration Methods 0.000 claims 1
- 239000007788 liquid Substances 0.000 abstract description 9
- 239000003153 chemical reaction reagent Substances 0.000 abstract description 7
- 238000000605 extraction Methods 0.000 abstract description 4
- 239000012528 membrane Substances 0.000 abstract description 4
- 239000000203 mixture Substances 0.000 abstract description 4
- 102000039446 nucleic acids Human genes 0.000 abstract description 4
- 108020004707 nucleic acids Proteins 0.000 abstract description 4
- 150000007523 nucleic acids Chemical class 0.000 abstract description 4
- 239000000843 powder Substances 0.000 abstract description 4
- 239000007787 solid Substances 0.000 abstract description 4
- 230000000694 effects Effects 0.000 abstract description 3
- 239000000463 material Substances 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 238000012864 cross contamination Methods 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
Abstract
nullThe utility model discloses a kind of sample processing device，Including the sample cell fitted together successively、Adsorption tube、Absorption base、Pierce through pipe and the component that fractures，Sample cell bottom has the first next door，Adsorption tube top has the second next door，Adsorption tube cover for seat is loaded on adsorption tube top and is connected with sample cell，In absorption base inner sleeve equipped with piercing through pipe，Pierce through the upper of pipe、Lower two ends are respectively formed with the first cutting edge、Second cutting edge，The component that fractures includes fracture base and the pipe that fractures，When carrying out nucleic acid extraction，Mix in putting samples into sample cell，Turning sample cell makes its extruding pierce through pipe and move down，At the first cutting edge、Under second cutting edge effect，Cut off the first next door respectively、Second next door，So that the liquid being positioned at the first cavity volume can flow to the second cavity volume，With the powder solid state reagents haptoreaction in the second cavity volume，Finally，Fracture pipe，The liquid being positioned at the second cavity volume is flowed out from the outlet of filter through filter membrane，Simple to operation.
Description
Technical field
This utility model relates to technical field of biological, particularly to a kind of sample processing device.
Background technology
At present, clinic usually needs to extract genomic DNA or RNA from various biological tissues or cell, and application nucleic acid expands
Increasing its composition of technical measurement, this is extremely sensitive for the complementary analysis of disease and the one of diagnosis, and the most directly examines
Survey means.Owing to clinical samples containing the material such as protein, lipid, amplified reaction downstream can be disturbed, therefore detecting
Process and the nucleic acid extraction of biological specimen must be carried out before reaction.
The most common sample treatment and consumptive material, there is problems in that (1) extracts process complicated；(2) need
Want professional auxiliary equipment；(3) strongly professional, operator's technology is required height；(4) extraction environment is open, there is sample room
Easy cross-contamination；(5) during extracting, the leakage of sample easily hurts operator.
Utility model content
Technical problem to be solved in the utility model is to provide that a kind of cost is low, compact conformation, easily operated sample
Processing means.
By solving the technical scheme that above-mentioned technical problem is used: a kind of sample processing device, including sample cell, its one end
Being connected with sample lid, the other end is provided with the first next door so that form the first cavity volume in sample cell；Adsorption tube, its one end
Being formed and install the mouth of pipe, the other end is connected with filter, is provided with the second next door so that in adsorption tube in the described installation mouth of pipe
Form the second cavity volume；Absorption base, one end is socketed in the installation mouth of pipe of adsorption tube, and the other end and sample cell have the first next door
One end be flexibly connected；Pierce through pipe, be set in absorption base in and by sample cell extruding can move down, described in pierce through pipe
Upper/lower terminal be respectively formed with to cut off the first next door, the second next door so that the first cavity volume and the second cavity volume be connected
One cutting edge, the second cutting edge, described first cutting edge is upwardly extended by puncture tube upper end edge tube wall edge and convexes to form, described
Second cutting edge is downwardly extended by puncture tube lower end edge tube wall edge and convexes to form；And the component that fractures, it is located at adsorption tube and mistake
Between filter, including base and the pipe that fractures that is connected with the base that fractures of fractureing, adsorption tube described in bending can under external force
Make to fracture pipe and separate with the base fracture that fractures, and then the second cavity volume is communicated with the outlet of filter.
Further, described first next door outer rim is connected by thin-walled with sample cell inwall, described second next door outer rim with
Adsorption tube inwall is connected by thin-walled.
Further, the circumferentially spaced multiple location draw runner that is provided with of pipe outer wall, described absorption base inwall tool are pierced through described in
Have and embed, for location draw runner, the positioning runner being slidably connected.
Further, described sample cell with absorption base threaded so that sample cell can relative to absorption base to
Lower movement with extruding be positioned at absorption base pierce through pipe.
Further, described adsorption tube seat pipe wall bottom is circumferentially spaced is provided with multiple locating notch, described adsorption tube
Internal wall of pipe orifice is installed and is formed with multiple locating convex block embedded in each locating notch.
Further, described in fracture base and filter clamping, described in the pipe that fractures stretch into for elongated rod shape and be in the second cavity volume
In, described in fracture base and be connected by thin-walled between pipe with fractureing.
Further, described in the component that fractures be polystyrene component, described adsorption tube is polyethylene component.
Further, described sample lid is threadeded with sample cell, and described filter is threadeded with adsorption tube.
Beneficial effect: in this sample processing device, places liquid reagent, the second of adsorption tube in the first cavity volume of sample cell
Place powder solid state reagents in cavity volume, when carrying out nucleic acid extraction, mix in putting samples into sample cell, then by sample
Pipe fits together with adsorption tube, turns sample cell and it is extruded pierce through pipe and move down, pierce through pipe the first cutting edge,
Under second cutting edge effect, cut off the first next door, the second next door respectively, so that the liquid being positioned at the first cavity volume can flow to
In second cavity volume, and the powder solid state reagents haptoreaction in the second cavity volume, finally, bending adsorption tube, and then fracture wherein
The pipe that fractures so that be positioned at the liquid of the second cavity volume and flow out from the outlet of filter through filter membrane, simple to operation.
Accompanying drawing explanation
With embodiment, this utility model is described further below in conjunction with the accompanying drawings；
Fig. 1 is the cross-sectional view of this utility model embodiment；
Fig. 2 is the decomposition texture schematic diagram of this utility model embodiment；
Fig. 3 is the structural representation adsorbing base in this utility model embodiment；
Fig. 4 is the upward view adsorbing base in this utility model embodiment；
Fig. 5 is the structural representation piercing through pipe in this utility model embodiment；
Fig. 6 is the cross-sectional view of component of fractureing in this utility model embodiment.
Detailed description of the invention
Referring to figs. 1 through Fig. 6, this utility model one sample processing device, including sample cell 10, its one end is connected with
Sample lid 11, the other end is provided with the first next door 12 so that form the first cavity volume 13 in sample cell 10；Adsorption tube 20, its one end
Being formed and install the mouth of pipe 21, the other end is connected with filter 22, is provided with the second next door 23 in installing the mouth of pipe 21 so that absorption
The second cavity volume 24 is formed in pipe 20；Absorption base 30, one end is socketed in the installation mouth of pipe 21 of adsorption tube, the other end and sample cell
10 one end with the first next door 12 are flexibly connected；Piercing through pipe 40, in being set in absorption base 30 and being extruded by sample cell 10 can
Moving down, the upper/lower terminal piercing through pipe 40 is respectively formed with to cut off the 12, second next door 23, the first next door so that first holds
First cutting edge the 41, second cutting edge 42 that chamber 13 is connected with the second cavity volume 24；And the component 50 that fractures, it is located at adsorption tube 20
And between filter 22, including base 51 and fracture pipe 52, the under external force bending that are connected with the base 51 that fractures of fractureing
Adsorption tube 20 can make to fracture pipe 52 and separate with base 51 fracture that fractures, and then makes the outlet of the second cavity volume 24 and filter 22
Communicate.
This sample processing device by sample cell 10, adsorption tube 20, absorption base 30, pierce through pipe 40 and the component 50 that fractures assembles
Being formed, sample cell 10 top connects sample lid 11, and absorption base 30 bottom connects has filter 22, filter membrane 53 to be arranged on suction
Between attached base 30 and filter 22.
Wherein, sample cell 10 top is threaded sample lid 11, and bottom is then blocked by the first next door 12, from
And make the first cavity volume 13 constitute sealed volume, it is pre-placed liquid reagent in the first cavity volume 13, by opening sample lid
11 add sample, carry out preliminary hybrid reaction.Wherein, the first next door 12 outer rim is connected by thin-walled, i.e. with sample cell 10 inwall
The junction wall thickness of the first next door 12 outer rim and sample cell 10 inwall is less than the wall thickness in the first next door 12, under external force, and should
It is easily broken off at thin-walled.
Adsorption tube 20 bottom is threaded filter 22, and top is formed installs the mouth of pipe 21, is positioned at the installation mouth of pipe 21 and sets
Putting the second next door 23 to block, a segment distance is left with installing in the second next door 23 at the mouth of pipe of the mouth of pipe 21, thus also makes the
Two cavity volumes 24 constitute sealed volume.Wherein, the second next door 23 outer rim is connected by thin-walled with adsorption tube 20 inwall, the i.e. second next door
The junction wall thickness of 23 outer rims and adsorption tube 20 inwall is less than the wall thickness in the second next door 23, under external force, holds at this thin-walled
Easy fracture.
Absorption base 30 is arranged in the installation mouth of pipe 21 of adsorption tube 20, and specifically, the bottom tube wall of absorption base 30 is straight
Footpath is suitable with the inner diameter installing the mouth of pipe 21, but installs inwall at the mouth of pipe 21 mouth of pipe and reduce so that the end of absorption base 30
Portion is socketed in the installation mouth of pipe 21, it is to avoid absorption base 30 comes off, and wherein, absorption base 30 and sample cell 10 are to use screw thread even
Connect, thus turn sample cell 10, sample cell 10 can be made to move down relative to absorption base 30, at the bottom of absorption base 30 tube wall
Holding and circumferentially spaced be provided with multiple locating notch 31, the installation mouth of pipe 21 inwall of adsorption tube 20 is formed and multiple embeds each location
Locating convex block 25 in notch 31, coordinates clamping by locating notch 31 with locating convex block 25, can limit absorption base 30 weeks
To rotation.
Pierce through pipe 40 upper end, lower end forms the first cutting edge 41 and the second cutting edge 42 respectively, and the first cutting edge 41 is by wearing
Thorn pipe 40 upper end edge tube wall edge upwardly extends and convexes to form, and the first cutting edge 41 is pointed component, the first cutting edge 41 and the
At the thin-walled of one next door 12 outer rim corresponding；Second cutting edge 42 is downwardly extended convex shaped by puncture tube 40 lower end edge tube wall edge
Becoming, the second cutting edge 42 is also pointed component, corresponding with at the thin-walled of the second next door 23 outer rim, when turning sample cell 10,
Pipe 40 is pierced through in sample cell 10 extruding makes it move down, and owing to the outer rim in the first next door 12 and the second next door 23 is thin-walled, pierces through
The first cutting edge 41 and the second cutting edge 42 on pipe 40 fast and easy can cut off the first next door 12 and outer rim in the second next door 23
At thin-walled, so that the first cavity volume 13 is connected with the second cavity volume 24.Wherein, the distance that the second cutting edge 42 protrudes is greater than
The distance that first cutting edge 41 protrudes, thus when puncture tube 40 moves down, be initially switched off the second next door 23, cut off first the most again
Next door 12, the 23, first next door 12, the i.e. second next door is the most cut-off successively isolates.Piercing through, pipe 40 outer wall is circumferentially spaced
Being provided with multiple location draw runner 43, absorption base 30 inwall has the positioning runner 32 being slidably connected for location draw runner 43 embedding, logical
Crossing location draw runner 43 to coordinate with positioning runner 32, restriction is pierced through pipe 40 and is circumferentially rotated.
Fractureing and fracture base 51 and pipe 52 integrated injection molding that fractures in component 50, fracture base 51 and filter 22 clamping
Fixing, the pipe 52 that fractures, for elongated rod shape, stretches into and is in the second cavity volume 24, and fracture base 51 and fracture between pipe 52 by thin-walled even
Connecing, this thin-walled junction constitutes angular cut, and the component 50 that fractures uses polystyrene material to constitute so that the component 50 that fractures has one
Determine fragility, thus move when fractureing pipe 52 under external force, can make to fracture pipe 52 and the base 51 that fractures is disconnected at angular cut
Splitting separation, wherein, adsorption tube 20 uses polythene material to constitute so that adsorption tube 20 has good flexibility, by directly
The most broken pipe 52 that fractures being positioned at adsorption tube 20 of bending adsorption tube 20, and then make going out of the second cavity volume 24 and filter 22
Mouth communicates.
The specifically used process of this utility model sample processing device is as follows: inspected object uses sample add to sample
In first cavity volume 13 of pipe 10, mix with the liquid reagent being placed with in advance in the first cavity volume 13, turn sample cell 10 and it is squeezed
Pressure pierces through pipe 40 and moves down, under first cutting edge the 41, second cutting edge 42 effect piercing through pipe 40 upper/lower terminal, respectively
Cut off the 12, second next door 23, the first next door, so that the liquid being positioned at the first cavity volume 13 can flow to the second cavity volume 24, with
The powder solid state reagents haptoreaction being placed with in advance in second cavity volume 24, finally, bending adsorption tube 20, enters under external force
And the pipe 52 that fractures being connected with the base 51 that fractures that fractures, it is positioned at the liquid of the second cavity volume 24 through filter membrane 53 from filter 22
Outlet is flowed out.
Above in conjunction with accompanying drawing, embodiment of the present utility model is explained in detail, but on this utility model is not limited to
State embodiment, in the ken that described technical field those of ordinary skill is possessed, it is also possible to without departing from this practicality
On the premise of novel objective, various changes can be made.
Claims (8)
1. a sample processing device, it is characterised in that include
Sample cell, its one end is connected with sample lid, and the other end is provided with the first next door so that form the first appearance in sample cell
Chamber；
Adsorption tube, its one end is formed installs the mouth of pipe, and the other end is connected with filter, is provided with second in the described installation mouth of pipe
Next door so that form the second cavity volume in adsorption tube；
Absorption base, one end is socketed in the installation mouth of pipe of adsorption tube, and the other end and sample cell have the one end in the first next door and live
It is dynamically connected；
Pierce through pipe, can move down in being set in absorption base and by sample cell extruding, described in pierce through the upper/lower terminal of pipe respectively
Be formed to cut off the first next door, the second next door so that the first cavity volume and the second cavity volume be connected the first cutting edge, second
Cutting edge, described first cutting edge is upwardly extended by puncture tube upper end edge tube wall edge and convexes to form, described second cutting edge by
Puncture tube lower end edge tube wall edge downwardly extends and convexes to form；And
Fracture component, is located between adsorption tube and filter, including base and the pipe that fractures that is connected with the base that fractures of fractureing,
Under External Force Acting, adsorption tube described in bending can make to fracture pipe and separates with the base fracture that fractures, and then makes the second cavity volume and filtration
The outlet of device communicates.
Sample processing device the most according to claim 1, it is characterised in that: described first next door outer rim and sample cell inwall
Being connected by thin-walled, described second next door outer rim is connected by thin-walled with adsorption tube inwall.
Sample processing device the most according to claim 1, it is characterised in that pierce through described in: that pipe outer wall is circumferentially spaced to be provided with
Multiple location draw runner, described absorption base inwall has the positioning runner being slidably connected for location draw runner embedding.
Sample processing device the most according to claim 1, it is characterised in that: described sample cell is with absorption base screw thread even
Connect so that sample cell can relative to absorption base move down with extruding be positioned at absorption base pierce through pipe.
5. according to the sample processing device described in claim 1 or 4, it is characterised in that: described adsorption tube seat pipe wall bottom is along week
To being interval with multiple locating notch, the internal wall of pipe orifice of installing of described adsorption tube is formed with multiple embedding in each locating notch
Locating convex block.
Sample processing device the most according to claim 1, it is characterised in that fracture described in: base and filter clamping, institute
Stating the pipe that fractures to stretch into for elongated rod shape and to be in the second cavity volume, described in fracture base and be connected by thin-walled between pipe with fractureing.
Sample processing device the most according to claim 1, it is characterised in that the component that fractures described in: is polystyrene component,
Described adsorption tube is polyethylene component.
Sample processing device the most according to claim 1, it is characterised in that: described sample lid is with sample cell screw thread even
Connecing, described filter is threadeded with adsorption tube.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620763138.1U CN205856451U (en) | 2016-07-18 | 2016-07-18 | A kind of sample processing device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620763138.1U CN205856451U (en) | 2016-07-18 | 2016-07-18 | A kind of sample processing device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN205856451U true CN205856451U (en) | 2017-01-04 |
Family
ID=57647423
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201620763138.1U Active CN205856451U (en) | 2016-07-18 | 2016-07-18 | A kind of sample processing device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN205856451U (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108786951A (en) * | 2017-08-17 | 2018-11-13 | 北京诺亚威仪器仪表有限公司 | A kind of reagent detection pipe and reagent detect tube assembly |
| CN109507412A (en) * | 2017-09-15 | 2019-03-22 | 杭州博拓生物科技股份有限公司 | The device and method of analyte in a kind of detection sample |
| CN112393960A (en) * | 2020-11-06 | 2021-02-23 | 奥然生物科技（上海）有限公司 | Sample pretreatment device and sample pretreatment method using same |
-
2016
- 2016-07-18 CN CN201620763138.1U patent/CN205856451U/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108786951A (en) * | 2017-08-17 | 2018-11-13 | 北京诺亚威仪器仪表有限公司 | A kind of reagent detection pipe and reagent detect tube assembly |
| CN109507412A (en) * | 2017-09-15 | 2019-03-22 | 杭州博拓生物科技股份有限公司 | The device and method of analyte in a kind of detection sample |
| CN112393960A (en) * | 2020-11-06 | 2021-02-23 | 奥然生物科技（上海）有限公司 | Sample pretreatment device and sample pretreatment method using same |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN205856451U (en) | A kind of sample processing device | |
| US20070275475A1 (en) | Rapid Test Apparatus | |
| JP2019502103A (en) | Assay device | |
| JP2006308428A (en) | Nucleic acid analysis method, nucleic acid analyzer, and cartridge for nucleic acid analysis | |
| CN106990193B (en) | Pretreatment device and method for solid-phase extraction sample | |
| CN111733066A (en) | Integrated reagent cup for sample treatment and detection and method for detecting sample | |
| CN108220125A (en) | A kind of nucleic acid rapid extraction device | |
| CN105836240A (en) | Tube breaking mechanism, sealed test tube assembly comprising tube breaking mechanism and application thereof | |
| CN205209809U (en) | Trace liquid sampling device application of sample device and blood sampling external member thereof | |
| CN206270093U (en) | A kind of device collected and detect | |
| CN111321065B (en) | Trace biological sample purification pretreatment method and device | |
| CN206387600U (en) | A kind of sample processing device | |
| CN107629939A (en) | A kind of sample processing device | |
| CN106000497A (en) | Novel sucker and dropper kit | |
| CN208171631U (en) | Sample device and its package body | |
| CN115820412A (en) | Microfluidic card box and method for specifically detecting nucleic acid from complex sample | |
| US20190154549A1 (en) | Detection device and method of using the same | |
| CN203436330U (en) | Blood sampling and containing component and blood sampling device | |
| CN204649474U (en) | A kind of microbiological analysis sampler | |
| CN105716905B (en) | A kind of sample collection detection method | |
| CN212293516U (en) | Integrated adding device for pretreatment reagent of biological sample | |
| CN115029210A (en) | Closed type rapid nucleic acid extraction device and extraction method adopting one-step method | |
| CN204744197U (en) | Novel micro - heparin tube of ration | |
| CN104819870A (en) | Microorganism analytical sampling device | |
| CN204903478U (en) | Preceding processing apparatus that nitrosamine mark detected |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Guangzhou Kaide Finance Leasing Co.,Ltd. Assignor: GUANGZHOU DEAOU BIOTECHNOLOGY Co.,Ltd. Contract record no.: X2020980006140 Denomination of utility model: A sample processing device Granted publication date: 20170104 License type: Exclusive License Record date: 20200917 |
|
| EE01 | Entry into force of recordation of patent licensing contract | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of utility model: A sample processing device Effective date of registration: 20200918 Granted publication date: 20170104 Pledgee: Guangzhou Kaide Finance Leasing Co.,Ltd. Pledgor: GUANGZHOU DEAOU BIOTECHNOLOGY Co.,Ltd. Registration number: Y2020980006189 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| EC01 | Cancellation of recordation of patent licensing contract |
Assignee: Guangzhou Kaide Finance Leasing Co.,Ltd. Assignor: GUANGZHOU DEAOU BIOTECHNOLOGY Co.,Ltd. Contract record no.: X2020980006140 Date of cancellation: 20231026 |
|
| EC01 | Cancellation of recordation of patent licensing contract | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20231026 Granted publication date: 20170104 Pledgee: Guangzhou Kaide Finance Leasing Co.,Ltd. Pledgor: GUANGZHOU DEAOU BIOTECHNOLOGY Co.,Ltd. Registration number: Y2020980006189 |
|
| PC01 | Cancellation of the registration of the contract for pledge of patent right |