CN112384808B - 用于减轻抗药物抗体（ada）免疫测定中的药物靶标干扰的方法 - Google Patents
用于减轻抗药物抗体（ada）免疫测定中的药物靶标干扰的方法 Download PDFInfo
- Publication number
- CN112384808B CN112384808B CN201980046236.XA CN201980046236A CN112384808B CN 112384808 B CN112384808 B CN 112384808B CN 201980046236 A CN201980046236 A CN 201980046236A CN 112384808 B CN112384808 B CN 112384808B
- Authority
- CN
- China
- Prior art keywords
- drug
- target
- ada
- drug target
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5306—Improving reaction conditions, e.g. reduction of non-specific binding, promotion of specific binding
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862696016P | 2018-07-10 | 2018-07-10 | |
| US62/696,016 | 2018-07-10 | ||
| PCT/US2019/040950 WO2020014194A1 (en) | 2018-07-10 | 2019-07-09 | Methods for mitigating drug target interference in an anti-drug antibody (ada) immunoassay |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN112384808A CN112384808A (zh) | 2021-02-19 |
| CN112384808B true CN112384808B (zh) | 2024-10-11 |
Family
ID=67544324
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201980046236.XA Active CN112384808B (zh) | 2018-07-10 | 2019-07-09 | 用于减轻抗药物抗体（ada）免疫测定中的药物靶标干扰的方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US12055551B2 (https=) |
| EP (1) | EP3821255B1 (https=) |
| JP (3) | JP7493459B2 (https=) |
| KR (1) | KR102754704B1 (https=) |
| CN (1) | CN112384808B (https=) |
| AU (1) | AU2019301614B2 (https=) |
| BR (1) | BR112020022912A2 (https=) |
| EA (1) | EA202190237A1 (https=) |
| ES (1) | ES2993989T3 (https=) |
| IL (1) | IL277888B2 (https=) |
| MA (1) | MA53130A (https=) |
| MX (1) | MX2021000331A (https=) |
| MY (1) | MY207418A (https=) |
| SG (1) | SG11202011283TA (https=) |
| WO (1) | WO2020014194A1 (https=) |
| ZA (1) | ZA202006409B (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2022011336A (es) * | 2020-03-17 | 2022-10-07 | Regeneron Pharma | Atenuacion de la interferencia de dianas en ensayo de anticuerpos antifarmacos. |
| CN114264814B (zh) * | 2021-12-30 | 2025-03-14 | 苏州和锐生物科技有限公司 | 一种pd-1生物制剂的抗体检测试剂盒及制备方法 |
| CN114324894A (zh) * | 2021-12-31 | 2022-04-12 | 军科正源（北京）药物研究有限责任公司 | 一种检测贝伐珠单抗抗药性抗体的新型分析方法 |
| CN114047343B (zh) * | 2022-01-13 | 2022-05-31 | 美迪西普亚医药科技(上海)有限公司 | 双耐受型抗IgE单抗药物的免疫原性分析试剂盒及其使用方法和应用 |
| JP2025514738A (ja) * | 2022-04-19 | 2025-05-09 | ソングァン メディカル ファンデーション | 血液中の抗薬物抗体濃度測定による生物学的薬物に対する治療反応性の予測方法 |
| WO2024044622A1 (en) * | 2022-08-24 | 2024-02-29 | Amgen Inc. | Anti-drug antibody assays |
| CN115586337A (zh) * | 2022-09-14 | 2023-01-10 | 杭州赛基生物科技有限公司 | 检测肿瘤伴随诊断相关因子的试剂盒及其制备方法 |
| CN120239821A (zh) * | 2022-09-23 | 2025-07-01 | 默沙东有限责任公司 | 中和抗体测定方法 |
| CN115575468B (zh) * | 2022-09-30 | 2025-08-26 | 华润生物医药有限公司 | 一种检测抗重组人GLP-1-Fc融合蛋白抗体的方法 |
| CN115856322A (zh) * | 2022-12-23 | 2023-03-28 | 同昕生物技术（北京）有限公司 | 用于抗奥马株单抗药物抗体检测的试剂及其应用 |
| CN117805382B (zh) * | 2024-02-28 | 2024-05-03 | 军科正源（北京）药物研究有限责任公司 | 检测抗利妥昔单抗中和抗体的方法 |
| WO2025224166A1 (en) * | 2024-04-23 | 2025-10-30 | F. Hoffmann-La Roche Ag | Anti-drug antibody assays |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3856469A (en) | 1973-01-02 | 1974-12-24 | Syva Corp | Interferant removal from amphetamine immunoassay |
| JPS55145690A (en) | 1979-05-04 | 1980-11-13 | Toyama Chem Co Ltd | Novel penicillin and cephalosporin, and its salt |
| JPS6454356A (en) * | 1987-08-26 | 1989-03-01 | Meidensha Electric Mfg Co Ltd | Method for suppressing non-specific adsorption of antibody to solid phase antigen |
| JPH02138872A (ja) * | 1988-11-18 | 1990-05-28 | Asahi Chem Ind Co Ltd | 癌関連物質のための免疫測定方法 |
| US20060281132A1 (en) * | 2003-09-26 | 2006-12-14 | Fumihisa Kitawaki | Method of immunoreaction measurement and, for use therein, reagent, kit and optical cell |
| CN101680880A (zh) | 2007-05-07 | 2010-03-24 | 惠氏公司 | 免疫检定中由抗碳水化合物抗体引起的干扰的消除 |
| WO2009022001A1 (en) | 2007-08-16 | 2009-02-19 | Novartis Ag | Improvement of drug tolerance in immunogenicity testing |
| DK2723769T4 (da) * | 2011-06-23 | 2022-09-05 | Ablynx Nv | Teknikker til at forudsige, påvise og reducere uspecifik proteininterferens i assays, som involverer variable immunglobulin-enkeltdomæner |
| CN105378480B (zh) * | 2013-07-04 | 2018-06-12 | 豪夫迈·罗氏有限公司 | 检测血清样品中抗药物抗体的干扰抑制性免疫测定 |
| CA2939080A1 (en) * | 2014-02-11 | 2015-08-20 | Genzyme Corporation | Assays for detecting the presence or amount of an anti-drug antibody |
| WO2017096262A1 (en) * | 2015-12-04 | 2017-06-08 | Jomoco, Corp. | Compositions and methods to mitigate or prevent an immune response to an immunogenic therapeutic molecule in non-human primates |
| US20190145985A1 (en) | 2017-11-10 | 2019-05-16 | BioAgilytix Labs, LLC | Method for eliminating target interference |
| AU2018374469B2 (en) | 2017-11-29 | 2022-06-16 | F. Hoffmann-La Roche Ag | Target interference suppressed anti-drug antibody assay |
| MX2022011336A (es) * | 2020-03-17 | 2022-10-07 | Regeneron Pharma | Atenuacion de la interferencia de dianas en ensayo de anticuerpos antifarmacos. |
-
2019
- 2019-07-09 SG SG11202011283TA patent/SG11202011283TA/en unknown
- 2019-07-09 WO PCT/US2019/040950 patent/WO2020014194A1/en not_active Ceased
- 2019-07-09 KR KR1020207033049A patent/KR102754704B1/ko active Active
- 2019-07-09 IL IL277888A patent/IL277888B2/en unknown
- 2019-07-09 MY MYPI2020005155A patent/MY207418A/en unknown
- 2019-07-09 CN CN201980046236.XA patent/CN112384808B/zh active Active
- 2019-07-09 MX MX2021000331A patent/MX2021000331A/es unknown
- 2019-07-09 JP JP2020564556A patent/JP7493459B2/ja active Active
- 2019-07-09 MA MA053130A patent/MA53130A/fr unknown
- 2019-07-09 EP EP19749872.8A patent/EP3821255B1/en active Active
- 2019-07-09 EA EA202190237A patent/EA202190237A1/ru unknown
- 2019-07-09 BR BR112020022912-1A patent/BR112020022912A2/pt unknown
- 2019-07-09 US US16/506,379 patent/US12055551B2/en active Active
- 2019-07-09 ES ES19749872T patent/ES2993989T3/es active Active
- 2019-07-09 AU AU2019301614A patent/AU2019301614B2/en active Active
-
2020
- 2020-10-15 ZA ZA2020/06409A patent/ZA202006409B/en unknown
-
2024
- 2024-02-20 JP JP2024023599A patent/JP2024045646A/ja active Pending
- 2024-07-03 US US18/763,265 patent/US20240353423A1/en active Pending
-
2025
- 2025-10-23 JP JP2025179025A patent/JP2026012856A/ja active Pending
Non-Patent Citations (1)
| Title |
|---|
| Development of a method that eliminates false-positive results due to nerve growth factor interference in the assessment of fulranumab immunogenicity;Dai S等;AAPS J;第16卷(第03期);第464-477页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN112384808A (zh) | 2021-02-19 |
| IL277888B1 (en) | 2024-12-01 |
| MY207418A (en) | 2025-02-26 |
| US20240353423A1 (en) | 2024-10-24 |
| ZA202006409B (en) | 2025-07-30 |
| KR20210031854A (ko) | 2021-03-23 |
| AU2019301614B2 (en) | 2025-11-20 |
| JP2026012856A (ja) | 2026-01-27 |
| JP2024045646A (ja) | 2024-04-02 |
| EP3821255B1 (en) | 2024-08-28 |
| BR112020022912A2 (pt) | 2021-02-23 |
| KR102754704B1 (ko) | 2025-01-20 |
| MA53130A (fr) | 2021-05-19 |
| JP7493459B2 (ja) | 2024-05-31 |
| US12055551B2 (en) | 2024-08-06 |
| WO2020014194A1 (en) | 2020-01-16 |
| IL277888B2 (en) | 2025-04-01 |
| IL277888A (en) | 2020-11-30 |
| ES2993989T3 (en) | 2025-01-15 |
| MX2021000331A (es) | 2021-03-25 |
| EP3821255A1 (en) | 2021-05-19 |
| CA3098206A1 (en) | 2020-01-16 |
| AU2019301614A1 (en) | 2020-10-22 |
| US20200018770A1 (en) | 2020-01-16 |
| JP2021531448A (ja) | 2021-11-18 |
| SG11202011283TA (en) | 2020-12-30 |
| EA202190237A1 (ru) | 2021-04-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN112384808B (zh) | 用于减轻抗药物抗体（ada）免疫测定中的药物靶标干扰的方法 | |
| JP7105970B1 (ja) | ＳＡＲＳ－ＣｏＶ－２の免疫測定方法及び免疫測定キット | |
| JP7216948B1 (ja) | ＳＡＲＳ－ＣｏＶ－２の免疫測定方法及び免疫測定キット、並びにモノクローナル抗体又はその抗体断片 | |
| CN103109190B (zh) | 用于测量结合治疗性单克隆抗体的抗体的测定法 | |
| WO2018227643A1 (zh) | 一种用于脂肪性肝炎检测的靶标志物gp73及检测应用方法 | |
| CN108535490A (zh) | 生物制剂血药浓度检测方法及试剂 | |
| KR20180135071A (ko) | 바이러스 항원의 혈청학적 탐지 방법 | |
| KR20190010636A (ko) | Hcv 코어 항원의 신속한 검출을 위한 전처리 방법 | |
| CA3098206C (en) | Methods for mitigating drug target interference in an anti-drug antibody (ada) immunoassay | |
| JP2024534638A (ja) | 薬物濃度及び標的濃度を定量化するためのアッセイ | |
| EA051332B1 (ru) | Способы уменьшения мешающего влияния мишени лекарственного средства в иммунологическом анализе на антитела к лекарственному средству (ada) | |
| EA045148B1 (ru) | Способы уменьшения мешающего влияния мишени лекарственного средства в иммунологическом анализе на антитела к лекарственному средству (ada) | |
| CN111316100B (zh) | 检测急性博尔纳病病毒(bdv)感染的方法及其诊断试剂盒，特别是组合区分急性及慢性和潜伏性bdv感染的方法及其诊断试剂盒 | |
| US20250052768A1 (en) | In vitro methods for detecting dll1 | |
| JP6329127B2 (ja) | 細胞フィブロネクチンについての迅速な検査 | |
| WO2022202876A1 (ja) | Ｉ型コラーゲンｃ末端テロペプチドの免疫学的分析方法 | |
| KR101539150B1 (ko) | 자가면역 항체 검출방법 및 이를 이용한 자가면역 항체 검출키트 | |
| WO2017033846A1 (ja) | 免疫試験方法および免疫試験キット | |
| HK40109436A (zh) | 抑制靶干扰作用的抗药物抗体测定法 | |
| CN115925846A (zh) | 用于检测针对Ses iPR-10变应原的抗体的方法和试剂 | |
| HK40031674A (en) | Target interference suppressed anti-drug antibody assay | |
| HK40031674B (zh) | 抑制靶干扰作用的抗药物抗体测定法 | |
| HK1180767B (en) | An assay for measurement of antibodies binding to a therapeutic monoclonal antibody |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |