CN112370406A

CN112370406A - Low-irritation sunscreen lotion and preparation method thereof

Info

Publication number: CN112370406A
Application number: CN202011384731.2A
Authority: CN
Inventors: 孙怀庆; 裴运林; 胡越; 聂艳峰; 郭朝万; 胡露
Original assignee: Guangdong Marubi Biological Technology Co Ltd
Current assignee: Guangdong Marubi Biological Technology Co Ltd
Priority date: 2020-11-30
Filing date: 2020-11-30
Publication date: 2021-02-19
Also published as: JP7209056B2; JP2022086994A

Abstract

The invention discloses a low-irritation sunscreen lotion and a preparation method thereof. The low-irritation sun block comprises the following components: 0.5-5% of emulsifier, 0.1-5% of thickener, 10-15% of first sunscreen agent-coated complex, 20-30% of second sunscreen agent-coated complex, 0.02-0.2% of first soothing and anti-allergy agent, 0.1-1% of second soothing and anti-allergy agent, 0.01-0.3% of magnolol, 5-10% of 1, 3-butanediol, 0.2-2% of glucosyl rutin, 3-6% of polydimethylsiloxane, 0.1-0.5% of xanthan gum, 0.1-1% of preservative and 30-60% of water, wherein the sum of the mass percentages of the components is 100%. The low-irritation sunscreen emulsion prepared by the invention has high sunscreen index, good stability and mild property, avoids irritation to skin caused by direct contact of a sunscreen agent with the skin, and has fresh skin feel and no greasy feel.

Description

Low-irritation sunscreen lotion and preparation method thereof

Technical Field

The invention relates to the technical field of sunscreen, relates to sunscreen and a preparation method thereof, and particularly relates to low-irritation sunscreen and a preparation method thereof.

Background

The sunscreen emulsion is a skin care product prepared by utilizing a sunscreen principle to protect skin from ultraviolet radiation so as to prevent melanin from generating and accumulating, and is applied to the skin to prevent sunlight from contacting the skin. Compared with sunscreen cream, sunscreen cream is more refreshing because it contains more water, and thus is favored by more consumers.

Sunscreen emulsions add sunscreen agents to act as sunscreens, and some sunscreen agents are irritating by direct contact with the skin, and thus may cause skin redness, irritation, and other discomfort to some people with sensitive skin after use of the sunscreen emulsion product.

CN108670890B discloses an organic sunscreen composition and application thereof, belonging to the technical field of cosmetics and skin care products. The organic sunscreen composition is prepared from the following raw materials: ethylhexyl methoxycinnamate, C12-15 alcohol benzoate, isopropyl lauroyl sarcosinate, octocrylene, bis-ethylhexyloxyphenol methoxyphenyl triazine, octyl methicone, ethylhexyl triazone, hexyl diethylamino hydroxybenzoyl benzoate, isodecyl pivalate, butyl methoxydibenzoyl methane. The organic sunscreen composition comprises the ultraviolet absorbers with different wave bands, can play a good sunscreen effect, has the characteristics of good compatibility and high refreshing degree, and can bring a pleasant skin feel while comprehensively protecting the skin. The organic sunscreen composition can be applied in cosmetics or skin care products, such as various dosage forms of sunscreen gel, sunscreen spray, sunscreen cream, color cosmetics with sunscreen effect, etc. Although the invention discloses sunscreen agents such as ethylhexyl methoxycinnamate, ethylhexyl triazone and butyl methoxydibenzoylmethane, the sunscreen agents directly contact with the skin to cause irritation to the skin, and the sunscreen agents have poor stability and risk of precipitation.

CN110613619A discloses a biological sunscreen composition containing fullerene and an aerosol. The biological sunscreen composition comprises the following preparation raw materials: fullerene, glucosylrutin, p-methoxy isoamyl cinnamate, polysiloxane-15, ethylhexyl triazone, diethylamino hydroxybenzoyl hexyl benzoate and bis-ethylhexyloxyphenol methoxyphenyl triazine. The raw material components of the biological sunscreen composition are green, environment-friendly, safe and harmless, and all bands of UVB, UVA, visible light and IRA can be comprehensively and effectively protected through the cooperation of all the raw materials, so that various skin problems such as skin diseases and skin injuries induced by sunlight can be effectively prevented, and the health and the good life of people can be better guaranteed. Although it discloses glucosylrutin and ethylhexyl triazone, it is not good for improving skin aging, facial flushing, skin inflammation and erythema problems of skin which occur in the sun.

Therefore, it is necessary to provide a sunscreen lotion which has a good sunscreen effect, is refreshing, has low irritation, and has good stability.

Disclosure of Invention

Aiming at the defects of the prior art, the invention aims to provide the low-irritation sunscreen emulsion and the preparation method thereof.

One of the purposes of the invention is to provide a sunscreen emulsion with low stimulation, and in order to achieve the purpose, the invention adopts the following technical scheme:

a low-irritation sun block comprising, in mass percent:

the sum of the mass percentages of the components is 100 percent.

According to the sunscreen emulsion, different coated sunscreens are used, so that not only can the synergy be achieved, but also the stability of the sunscreen is increased, the risk of crystallization and precipitation of the sunscreen is avoided, and the skin irritation caused by direct contact of the sunscreen with the skin is avoided; the soothing and anti-allergy agent and the free radical scavenger are added, so that the problems of skin aging, facial flushing, skin inflammation and erythema of the skin under sunlight can be relieved.

The first sunscreen agent coating compound is a mixture of methyl methacrylate cross-linked polymer, butyl methoxy dibenzoyl methane and ethylhexyl triazone.

Preferably, the mass ratio of the butyl methoxy dibenzoylmethane to the ethylhexyl triazone is (1-3): 1-5), for example, the ratio is 1:1, 1:2, 1:3, 1:4, 1:5, 2:1, 2:3, 2:5, 3:1, 3:2, 3:4 or 3:5, etc.

The second sunscreen agent coating compound is a mixture of water, ethylhexyl methoxycinnamate, silica, phenoxyethanol, polyvinylpyrrolidone, chlorphenesin, disodium edetate and butylated hydroxytoluene.

Preferably, the mass of the ethylhexyl methoxycinnamate is 10-30% of the second sunscreen-coated complex, for example, the mass of the ethylhexyl methoxycinnamate is 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, 21%, 22%, 23%, 24%, 25%, 26%, 27%, 28%, 29%, or 30% of the second sunscreen-coated complex, etc.

According to the invention, three coated sunscreens are selected, wherein butyl methoxy dibenzoyl methane and ethylhexyl triazone are coated by methyl methacrylate cross-linked polymer, and ethylhexyl methoxycinnamate is also coated, so that the synergistic effect can be achieved, the stability of the sunscreen is increased, the risk of crystallization and precipitation of the sunscreen is avoided, and the skin irritation caused by direct contact of the sunscreen is avoided.

The first soothing and anti-allergic agent is bisabolol and ginger (Zingiber OFFICINALE) root extract.

Preferably, the mass ratio of bisabolol to the extract of the root of ginger (ZINGIBER OFFICINALE) is 1 (1-3), such as 1:1, 1:1.5, 1:2, 1:2.5 or 1: 3.

The second soothing and anti-sensitivity agent is a mixture of butanediol, 1, 2-pentanediol, hydroxyphenylpropionamide benzoic acid, and ascorbyl palmitate.

Preferably, the mass ratio of the butanediol, the 1, 2-pentanediol, the hydroxyphenylpropionamide benzoic acid and the ascorbyl palmitate is 1:1 (1-3): 2-5.

The invention also adds a soothing and anti-allergy agent and a free radical scavenger, and the magnolol, glucosyl rutin, a first soothing and anti-allergy agent [ bisabolol, ginger (ginger OFFICINALE) root extract ], and a second soothing and anti-allergy agent (butanediol, 1, 2-pentanediol, hydroxyphenyl propionamide benzoic acid, and ascorbyl palmitate) can relieve the skin aging, face flushing, skin inflammation and erythema problems of the skin under the sunlight.

The emulsifier is glyceryl stearate and/or hydroxystearic acid.

The thickening agent is any one or a mixture of at least two of sodium acrylate/sodium acryloyldimethyl taurate copolymer, isohexadecane and polysorbate-80.

The preservative is any one or a mixture of at least two of ethylhexyl glycerol, propylene glycol and glyceryl caprylate.

The second purpose of the present invention is to provide a method for preparing the low-irritation sunscreen emulsion according to the first purpose, which comprises the following steps: adding an emulsifier, a thickener, polydimethylsiloxane and a first sunscreen agent-coated compound into an oil phase pot according to a ratio, heating, adding water, magnolol, 1, 3-butanediol, xanthan gum and a preservative into an emulsifying pot, heating, pumping the oil phase into the emulsifying pot, homogenizing, cooling, adding a second sunscreen agent-coated compound, glucosylrutin, a first soothing anti-allergy agent and a second soothing anti-allergy agent, and uniformly stirring to obtain the low-irritation sunscreen emulsion.

Wherein the temperature for heating the oil phase pot is 75-95 deg.C, such as 75 deg.C, 76 deg.C, 77 deg.C, 78 deg.C, 79 deg.C, 80 deg.C, 81 deg.C, 82 deg.C, 83 deg.C, 84 deg.C, 85 deg.C, 86 deg.C, 87 deg.C, 88 deg.C, 89 deg.C, 90 deg.C, 91 deg.C, 92 deg.C, 93 deg.C, 94 deg..

Preferably, the temperature of the emulsion is 75-95 deg.C, such as 75 deg.C, 76 deg.C, 77 deg.C, 78 deg.C, 79 deg.C, 80 deg.C, 81 deg.C, 82 deg.C, 83 deg.C, 84 deg.C, 85 deg.C, 86 deg.C, 87 deg.C, 88 deg.C, 89 deg.C, 90 deg.C, 91 deg.C, 92 deg.C, 93 deg.C, 94.

Preferably, the temperature of the oil phase after being pumped into the emulsifying pot is 40-50 deg.C, such as 40 deg.C, 41 deg.C, 42 deg.C, 43 deg.C, 44 deg.C, 45 deg.C, 46 deg.C, 47 deg.C, 48 deg.C, 49 deg.C or 50 deg.C.

Compared with the prior art, the invention has the beneficial effects that:

the low-irritation sunscreen lotion disclosed by the invention is mild, low in irritation, high in sunscreen index, good in stability, fresh and cool in skin feel and free of greasy feeling; by selecting the sunscreen agents wrapped by butyl methoxydibenzoylmethane, ethylhexyl triazone and ethylhexyl methoxycinnamate, the synergistic effect can be achieved, the stability of the sunscreen agents is increased, the risk of crystallization and precipitation of the sunscreen agents is avoided, and the skin irritation caused by direct contact of the sunscreen agents with the skin is avoided; and a soothing and anti-allergy agent and a free radical scavenger are also added, so that the problems of skin aging, facial flushing, skin inflammation and erythema of the skin in the sun can be relieved.

The preparation method is safe, simple, practical and feasible, is easy to operate in the production process, and can be used for batch production of the low-irritation sun-blocking lotion.

Detailed Description

The technical solution of the present invention is further explained by the following embodiments.

Unless otherwise specified, various starting materials of the present invention are commercially available or prepared according to conventional methods in the art.

Example 1

The low-irritation sunscreen lotion of the embodiment comprises the following components in percentage by mass:

wherein the first sunscreen coating compound is a mixture of methyl methacrylate cross-linked polymer, butyl methoxy dibenzoyl methane and ethylhexyl triazone, the mass ratio of the butyl methoxy dibenzoyl methane to the ethylhexyl triazone is 1:1, the second sunscreen coating compound is a mixture of water, ethylhexyl methoxycinnamate, silica, phenoxyethanol, polyvinylpyrrolidone, chlorphenesin, disodium ethylenediamine tetraacetate and butylated hydroxytoluene, the mass of the ethylhexyl methoxycinnamate accounts for 20% of the second sunscreen coating compound, the first soothing and anti-sensitizing agent is a mixture of bisabolol and ginger (ZIIBNGER OFINALE) root extract, the second soothing and anti-sensitizing agent is a mixture of butanediol, 1, 2-pentanediol, hydroxyphenylpropionamide benzoic acid and ascorbyl palmitate, the mass ratio of the ethylhexyl methoxycinnamate to the ethylhexyl methoxycinnamate is 1:1, the mass ratio of the ethylhexyl methoxycinnamate is 1:1, the first soothing and anti-sensitizing agent is a mixture of butanediol, 1, 2-pentanediol, hydroxyphenylpropionamide benzoic acid and ascorb, the emulsifier is glyceryl stearate, the thickener is isohexadecane, and the preservative is propylene glycol and glyceryl caprylate.

The preparation method of the low-irritation sun block of the embodiment comprises the following steps: adding the emulsifier, the thickener, the polydimethylsiloxane and the first sunscreen agent-coated compound into an oil phase pot according to the proportion, heating to 80 ℃, adding water, magnolol, 1, 3-butanediol, xanthan gum and a preservative into an emulsification pot, heating to 80 ℃, pumping the oil phase into the emulsification pot, homogenizing, cooling to 45 ℃, adding the second sunscreen agent-coated compound, glucosyl rutin, the first soothing anti-allergy agent and the second soothing anti-allergy agent, and uniformly stirring to obtain the low-irritation sunscreen emulsion.

Example 2

wherein the first sunscreen coating compound is a mixture of methyl methacrylate cross-linked polymer, butyl methoxy dibenzoyl methane and ethylhexyl triazone, the mass ratio of the butyl methoxy dibenzoyl methane to the ethylhexyl triazone is 1:1, the second sunscreen coating compound is a mixture of water, ethylhexyl methoxycinnamate, silica, phenoxyethanol, polyvinylpyrrolidone, chlorphenesin, disodium ethylenediamine tetraacetate and butylated hydroxytoluene, the mass of the ethylhexyl methoxycinnamate accounts for 20% of the second sunscreen coating compound, the first soothing and anti-sensitizing agent is a mixture of bisabolol and ginger (ZIIBNGER OFINALE) root extract, the second soothing and anti-sensitizing agent is a mixture of butanediol, 1, 2-pentanediol, hydroxyphenylpropionamide benzoic acid and ascorbyl palmitate, the mass ratio of the ethylhexyl methoxycinnamate to the ethylhexyl methoxycinnamate is 1:1, the mass ratio of the ethylhexyl methoxycinnamate is 1:1, the first soothing and anti-sensitizing agent is a mixture of butanediol, 1, 2-pentanediol, hydroxyphenylpropionamide benzoic acid and ascorb, the emulsifier is hydroxystearic acid, the thickener is sodium acrylate/sodium acryloyldimethyl taurate copolymer, and the preservative is ethylhexyl glycerol and propylene glycol.

Example 3

This example differs from example 1 in that the mass ratio of butyl methoxydibenzoylmethane and ethylhexyl triazone in the first sunscreen was 1:5, and the rest was the same as in example 1.

Example 4

This example differs from example 1 in that the first sunscreen coating complex is a mixture of methyl methacrylate crosspolymer and ethylhexyl triazone, without butyl methoxydibenzoylmethane, and the amount of reduced butyl methoxydibenzoylmethane is increased to methyl methacrylate crosspolymer, all other things being equal to example 1.

Example 5

This example differs from example 1 in that the first sunscreen coating complex was a mixture of butyl methoxydibenzoylmethane and ethylhexyl triazone, no methyl methacrylate crosspolymer was included, and the amount of methyl methacrylate crosspolymer decreased up to butyl methoxydibenzoylmethane, all other things being equal to example 1.

Example 6

This example differs from example 1 in that the second sunscreen-coated complex has 30% ethylhexyl methoxycinnamate by weight of the second sunscreen-coated complex, and is otherwise the same as example 1.

Example 7

This example differs from example 1 in that the first soothing anti-allergic agent is red myrrh, not containing ginger (ZINGIBER OFFICINALE) root extract, and is otherwise the same as example 1.

Example 8

This example differs from example 1 in that the first soothing anti-allergic agent is ginger (Zingiber OFFICINALE) root extract, red myrrh is not included, and the rest is the same as example 1.

Comparative example 1

This comparative example differs from example 1 in that, in the absence of the first sunscreen encapsulating compound, the reduced weight average is added to the other components to maintain the total weight constant, all other things being equal to example 1.

Comparative example 2

This comparative example differs from example 1 in that, in the absence of the second sunscreen encapsulating compound, the reduced weight average is added to the other components to maintain the total weight constant, all other things being equal to example 1.

Comparative example 3

This comparative example differs from example 1 in that the sunscreen was replaced with uncoated ethylhexyl methoxycinnamate, butyl methoxydibenzoylmethane and ethylhexyl triazone, all the others being identical to those of example 1.

Comparative example 4

This comparative example differs from example 1 in that no magnolol and glucosyl rutin were added, and the reduced amounts were added on average to the other components to ensure the total amount was unchanged, all other things being equal to example 1.

Comparative example 5

This comparative example differs from example 1 in that the first and second soothing anti-sensitivity agents are not added and the reduced amounts are added on average to the other components to ensure a constant total amount, all other being the same as in example 1.

1. Test items: the test method of the irritation test experiment and the chick embryo chorioallantoic membrane experiment comprises the following steps:

directly contacting a certain amount of test substances with chorioallantoic membrane blood vessels in the middle stage of hatched fertilized chicken embryos of 10-14 days, observing blood vessel injury after a period of action, and grading different blood vessel injury degrees, wherein the more serious the blood vessel injury is, the larger the score is.

Efficacy evaluation method and evaluation

The low-irritation sunscreen milks of examples 1 to 8 according to the invention and the samples of comparative examples 1,2, 3, 4, 5 were mixed at 2mg/cm²The coating density is uniformly coated on the middle chorioallantoic membrane of fertilized chick embryo of 10-14 days of incubation age, 37.5 DEG CCulturing at 55% humidity for 30min, washing the surface material with normal saline, observing blood vessel injury, and grading different blood vessel injury degrees.

The evaluation criteria are shown in table 1.

TABLE 1

Wherein 10 eggs were inseminated per sample and the test data are shown in table 2.

TABLE 2

2. Test items: skin feel evaluation, test method as follows:

30 healthy volunteers were selected, and the volunteers were divided into group A and group B, 15 persons each.

Volunteers included criteria: 1) healthy, without any history of skin or systemic disease; 2) male and female are not limited, and the age is 18-65 years old; 3) the attitude is serious, and the product can be used persistently; the excluded population is pregnant or lactating women, sensitive skin.

Application method

After cleansing, the low-irritation sunscreen milk or control sample was applied at 2mg/cm²The product is applied to the face part with uniform coating density once a day for 30 days.

Efficacy assessment methods were done in the form of questionnaires.

The main evaluation indexes are as follows: 1) sunscreen effect, evaluation scale was: the effect is obvious, the effect is general, and the effect is not in three levels; 2) the irritation index, the evaluation level is: 1) extreme irritation (red swelling, stabbing pain, pruritus, desquamation or other serious discomfort symptoms are generated in the using process), moderate irritation (the discomfort symptoms are very slight and basically imperceptible; no later stage exists at the beginning), no stimulation is generated (the whole using process is very comfortable, and no uncomfortable feeling exists); 3) the skin feel index is very dislike (sticky, unabsorbed, heavy and the like, poor spreadability), general and very good (fresh, easy to absorb and good spreadability).

The evaluation standard of the product is determined by three dimensions of sun-screening effect, irritation index and skin feeling index. The test results are shown in table 3 by comparing the percentage of preference of the user.

TABLE 3

From the data in table 3, it is found that the effect of the sunscreen emulsion of the present invention is almost as much as or even more significant than that of the sunscreen agent of the comparative example, the irritation is much lower than that of the comparative example, and the user is more likely to feel skin (one person in the comparative example is not tolerant to withdrawal).

According to the low-irritation sunscreen emulsion, after the sunscreen agent is coated, the stability of the sunscreen agent is improved, and the precipitation crystallization of the sunscreen agent is reduced.

The present invention is illustrated by the above-mentioned examples, but the present invention is not limited to the above-mentioned detailed process equipment and process flow, i.e. it is not meant to imply that the present invention must rely on the above-mentioned detailed process equipment and process flow to be practiced. It should be understood by those skilled in the art that any modification of the present invention, equivalent substitutions of the raw materials of the product of the present invention, addition of auxiliary components, selection of specific modes, etc., are within the scope and disclosure of the present invention.

The preferred embodiments of the present invention have been described in detail, however, the present invention is not limited to the specific details of the above embodiments, and various simple modifications may be made to the technical solution of the present invention within the technical idea of the present invention, and these simple modifications are within the protective scope of the present invention.

It should be noted that the various technical features described in the above embodiments can be combined in any suitable manner without contradiction, and the invention is not described in any way for the possible combinations in order to avoid unnecessary repetition.

In addition, any combination of the various embodiments of the present invention is also possible, and the same should be considered as the disclosure of the present invention as long as it does not depart from the spirit of the present invention.

Claims

1. A low-irritation sun block, which is characterized by comprising the following components in percentage by mass:

the sum of the mass percentages of the components is 100 percent.

2. The sunscreen emulsion of claim 1 wherein said first sunscreen encapsulating complex is a mixture of methyl methacrylate crosspolymer, butyl methoxydibenzoylmethane and ethylhexyl triazone;

preferably, the mass ratio of the butyl methoxy dibenzoylmethane to the ethylhexyl triazone is (1-3) to (1-5).

3. A sunscreen lotion as claimed in claim 1 or 2 wherein said second sunscreen agent encapsulating complex is a mixture of water, ethylhexyl methoxycinnamate, silica, phenoxyethanol, polyvinylpyrrolidone, chlorphenesin, disodium edetate and butylated hydroxytoluene;

preferably, the mass of the ethylhexyl methoxycinnamate accounts for 10-30% of the second sunscreen agent-coated complex.

4. A sunscreen emulsion as claimed in any one of claims 1 to 3 wherein said first soothing and anti-allergy agent is bisabolol and ginger root extract;

preferably, the mass ratio of the bisabolol to the ginger root extract is 1 (1-3).

5. A sunscreen emulsion as claimed in any one of claims 1 to 4 wherein said second soothing and anti-sensitizing agent is a mixture of butylene glycol, 1, 2-pentanediol, hydroxyphenylpropionamide benzoic acid and ascorbyl palmitate;

6. A sunscreen emulsion according to any of claims 1 to 5 wherein said emulsifier is any one or a mixture of at least two of glyceryl stearate and/or hydroxystearic acid.

7. A sunscreen emulsion as claimed in any one of claims 1 to 6 wherein said thickener is any one or a mixture of at least two of sodium acrylate/sodium acryloyldimethyl taurate copolymer, isohexadecane and polysorbate-80.

8. A sunscreen lotion according to any of claims 1 to 7 wherein said preservative is any one or a mixture of at least two of ethylhexyl glycerol, propylene glycol and glyceryl caprylate.

9. A process for the preparation of a low-irritation sunscreen according to any of claims 1 to 8 comprising the steps of: adding an emulsifier, a thickener, polydimethylsiloxane and a first sunscreen agent-coated compound into an oil phase pot according to a ratio, heating, adding water, magnolol, 1, 3-butanediol, xanthan gum and a preservative into an emulsifying pot, heating, pumping the oil phase into the emulsifying pot, homogenizing, cooling, adding a second sunscreen agent-coated compound, glucosylrutin, a first soothing anti-allergy agent and a second soothing anti-allergy agent, and uniformly stirring to obtain the low-irritation sunscreen emulsion.

10. The method of claim 9, wherein the temperature of the oil phase is 75-95 deg.C;

preferably, the temperature of adding the mixture into an emulsifying pot for heating is 75-95 ℃;

preferably, the temperature for reducing the temperature after pumping the oil phase into the emulsifying pot is 40-50 ℃.