CN112345792A - Micro-fluidic flow velocity detection device based on light propagation characteristic changes - Google Patents
Micro-fluidic flow velocity detection device based on light propagation characteristic changes Download PDFInfo
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- CN112345792A CN112345792A CN202011206919.8A CN202011206919A CN112345792A CN 112345792 A CN112345792 A CN 112345792A CN 202011206919 A CN202011206919 A CN 202011206919A CN 112345792 A CN112345792 A CN 112345792A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01P—MEASURING LINEAR OR ANGULAR SPEED, ACCELERATION, DECELERATION, OR SHOCK; INDICATING PRESENCE, ABSENCE, OR DIRECTION, OF MOVEMENT
- G01P5/00—Measuring speed of fluids, e.g. of air stream; Measuring speed of bodies relative to fluids, e.g. of ship, of aircraft
- G01P5/26—Measuring speed of fluids, e.g. of air stream; Measuring speed of bodies relative to fluids, e.g. of ship, of aircraft by measuring the direct influence of the streaming fluid on the properties of a detecting optical wave
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
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Abstract
The invention provides a microfluidic flow velocity detection device based on light propagation characteristic change, which comprises: the micro-fluidic chip comprises a micro-fluidic chip, a fiber core and a flexible layer, wherein a fluid channel is arranged on the surface of the micro-fluidic chip, the fiber core is arranged on the micro-fluidic chip and spans across the fluid channel, the flexible layer coats the fluid channel and the fiber core, and openings are respectively arranged at an inlet and an outlet of the fluid channel in the flexible layer. The invention has the advantage of high flow velocity detection precision.
Description
Technical Field
The invention relates to the field of microfluidic flow velocity detection, in particular to a microfluidic flow velocity detection device based on light propagation characteristic change.
Background
The microfluidic technology is an important platform for scientific research in the fields of fluid physics, biological laser technology, microreactors and the like. Microfluidic flow rate detection is an important link of microfluidic technology. The traditional flow velocity detection technology based on heat transfer and cantilever beam deformation has low precision.
Disclosure of Invention
In order to solve the above problems, the present invention provides a microfluidic flow velocity detection apparatus based on changes in light propagation characteristics, comprising: the micro-fluidic chip comprises a micro-fluidic chip, a fiber core and a flexible layer, wherein a fluid channel is arranged on the surface of the micro-fluidic chip, the fiber core is arranged on the micro-fluidic chip and spans across the fluid channel, the flexible layer coats the fluid channel and the fiber core, and openings are respectively arranged at an inlet and an outlet of the fluid channel in the flexible layer.
Furthermore, the fiber core is a micro-nano fiber core.
Further, the core is fixedly connected with the flexible layer.
Further, at the top of the flow channel, the core is in contact with the compliant layer.
Still further, a noble metal portion is included, the noble metal portion being secured to the flexible layer within the fluid passageway.
Further, the noble metal portion has a strip shape along the direction of the core, and the noble metal portion is in contact with the core.
Further, the material of the noble metal part is gold or silver.
Further, the fluid channel comprises precious metal particles fixed on the flexible layer in the fluid channel.
Furthermore, the noble metal particles are in contact with the core, and the noble metal particles are made of gold or silver.
Still further, the material of the flexible layer is polydimethylsiloxane.
The invention has the beneficial effects that: the invention provides a microfluidic flow velocity detection device based on light propagation characteristic change, which comprises: the micro-fluidic chip comprises a micro-fluidic chip, a fiber core and a flexible layer, wherein a fluid channel is arranged on the surface of the micro-fluidic chip, the fiber core is arranged on the micro-fluidic chip and spans across the fluid channel, the flexible layer coats the fluid channel and the fiber core, and openings are respectively arranged at an inlet and an outlet of the fluid channel in the flexible layer. When the fiber core is used, the light source emits laser, the laser is coupled into one end of the fiber core, the laser is emitted from the other end of the fiber core through the fiber core, and the optical detector detects the intensity of the emergent light; at the moment, fluid flows in the fluid channel, the flexible layer is bent outwards under the action of pressure, the environment around the fiber core and the shape of the optical fiber are changed, the propagation characteristic of the fiber core is changed, and the flow velocity measurement is realized by detecting the change of the propagation characteristic of the fiber core. The invention has the advantage of high flow velocity detection accuracy because the optical propagation characteristics of the fiber core are very sensitive to the periodic environmental changes.
The present invention will be described in further detail below with reference to the accompanying drawings.
Drawings
Fig. 1 is a schematic diagram of a microfluidic flow velocity detection device based on changes in light propagation characteristics.
Fig. 2 is a schematic diagram of another microfluidic flow velocity detection device based on changes in light propagation characteristics.
Fig. 3 is a schematic diagram of another microfluidic flow velocity detection device based on changes in light propagation characteristics.
In the figure: 1. a microfluidic chip; 2. a fluid channel; 3. a fiber core; 4. a flexible layer; 5. a noble metal part; 6. noble metal particles.
Detailed Description
To further explain the technical means and effects of the present invention adopted to achieve the intended purpose, the following detailed description of the embodiments, structural features and effects of the present invention will be made with reference to the accompanying drawings and examples.
Example 1
The invention provides a microfluidic flow velocity detection device based on light propagation characteristic change. As shown in fig. 1, the microfluidic flow velocity detection device based on the light propagation characteristic change comprises a microfluidic chip 1, a fiber core 3 and a flexible layer 4. The surface of the micro-fluidic chip 1 is provided with a fluid channel 2, and the cross section of the fluid channel 2 is rectangular. The fiber core 3 is arranged on the microfluidic chip 1, and the fiber core 3 crosses the fluid channel 2. The fiber core 3 is a micro-nano fiber core, that is, the fiber core 3 has a micro-nano size, so as to improve the coupling performance of light in the fiber core 3 with the outside. The flexible layer 4 covers the fluid channel 2 and the fiber core 3, and the flexible layer 4 is provided with openings at the inlet and the outlet of the fluid channel 2. At the top of the flow channel 2, the core 3 is fixedly connected to a flexible layer 4. That is, in the fluid passage 2, the core 3 and the flexible layer 4 are fixed together. Thus, when the flexible layer 4 is bent outward, the core 3 is bent and elongated by the flexible layer 4. The material of the flexible layer 4 is polydimethylsiloxane. The surface tension of the polydimethylsiloxane is small, and the polydimethylsiloxane can be bent outwards more under the action of the fluid. In addition, polydimethylsiloxane has good chemical stability and is suitable for a wider variety of fluids.
When the fiber core is used, the light source emits laser, the laser is coupled into one end of the fiber core, the laser is emitted from the other end of the fiber core through the fiber core, and the optical detector detects the intensity of the emergent light; the laser can be monochromatic laser or continuous spectrum laser. When the laser is monochromatic laser, the optical detector detects the intensity of emergent light so as to obtain a transmission coefficient; when the laser is a continuous spectrum laser, the light detector detects the transmission spectrum of the emergent light. Fluid flows in the fluid channel 2, the flexible layer 4 is outwards bent under pressure, and the fiber core 3 is bent and extended under the driving of the flexible layer 4, so that the propagation characteristic of the fiber core 3 is changed, and the flow rate measurement is realized by detecting the change of the propagation characteristic of the fiber core 3. The optical propagation characteristic of the fiber core 3 is very sensitive to the shape change, so the invention has the advantage of high flow velocity detection precision.
In addition, the fiber core 3 is arranged below the flexible layer 4, and the flexible layer 4 can be bent under the action of fluid, so that the light propagation characteristic of the fiber core 3 is changed; and the core 3 can be coated so that the light propagation characteristics of the core 3 are less affected by the external environment.
In addition, in practical applications, the core 3 may also be an optical fiber, only the exposed core 3 in the flow channel 2.
Example 2
On the basis of example 1, the core 3 is in contact with the flexible layer 4 at the top of the flow channel 2. That is, within the fluid channel 2, the core 3 is only in contact with the flexible layer 4, rather than being connected together. Thus, when the flexible layer 4 is bent outward, the flexible layer 4 is separated from the core 3, thereby changing the environment around the core 3, changing the effective refractive index of the environment around the core 3, and thus changing the light propagation characteristics of the core 3. Since the optical propagation characteristics of the fiber core 3, particularly the micro-nano fiber core, are very sensitive to the surrounding environment, the embodiment has the advantage of high flow velocity detection accuracy.
Example 3
In addition to embodiment 2, as shown in fig. 2, the flexible layer further includes a noble metal part 5, and the noble metal part 5 is fixed on the flexible layer 4 in the fluid channel 2. The noble metal part 5 has a strip shape along the direction of the core 3, and the noble metal part 5 is in contact with the core 3. The material of the noble metal portion 5 is gold or silver. When the flexible layer 4 is bent outward, the fiber core 3 is separated from the noble metal portion 5, so that the coupling between the fiber core 3 and the noble metal portion 5 is changed, and because the coupling between the fiber core 3 and the noble metal portion 5 is strong, the change in the interval between the fiber core 3 and the noble metal portion 5 can more seriously affect the light propagation characteristics of the fiber core 3, thereby realizing more accurate flow velocity detection. In addition, the noble metal part 5 is strip-shaped, so that on one hand, the area of the noble metal part 5 is reduced, and the blocking effect of the noble metal part 5 on the bending of the flexible layer 4 is reduced, so that the flexible layer 4 can be bent to a larger extent; on the other hand, surface plasmon resonance is more easily formed on noble metal section 5, thereby enhancing coupling between core 3 and noble metal section 5. The two effects are beneficial to improving the influence of the flow velocity change on the optical propagation characteristics of the fiber core 3, thereby improving the accuracy of flow velocity detection.
Example 4
On the basis of the embodiment 2, as shown in fig. 3, the fluid flow channel further comprises noble metal particles 6, and the noble metal particles 6 are fixed on the flexible layer 4 in the fluid flow channel 2. The noble metal particles 6 are in contact with the fiber core 3, and the material of the noble metal particles 6 is gold or silver. On the one hand, the noble metal particles 6 have less resistance to bending of the flexible layer 4, thereby causing a larger magnitude of bending of the flexible layer 4; on the other hand, localized surface plasmon resonances are more easily formed on the noble metal particles 6. As described above, both of these effects are beneficial to improve the influence of the flow velocity change on the optical propagation characteristics of the fiber core 3, thereby improving the accuracy of flow velocity detection.
Further, the noble metal particles 6 are periodically arranged, the noble metal particles 6 have the same size, and the noble metal particles 6 have the same shape, so that resonance with the same wavelength is formed on the noble metal particles 6, and thus a distinct transmission valley is formed in the transmission spectrum, thereby reducing the difficulty of detection and data analysis.
The foregoing is a more detailed description of the invention in connection with specific preferred embodiments and it is not intended that the invention be limited to these specific details. For those skilled in the art to which the invention pertains, several simple deductions or substitutions can be made without departing from the spirit of the invention, and all shall be considered as belonging to the protection scope of the invention.
Claims (10)
1. A microfluidic flow velocity detection device based on changes in light propagation characteristics, comprising: the fiber core is arranged on the surface of the microfluidic chip and stretches across the fluid channel, the flexible layer covers the fluid channel and the fiber core, and openings are respectively formed in an inlet and an outlet of the fluid channel of the flexible layer.
2. The microfluidic flow velocity detection device based on the change of the light propagation characteristic according to claim 1, wherein: the fiber core is a micro-nano fiber core.
3. The microfluidic flow velocity detection device based on the change of the light propagation characteristic according to claim 2, wherein: the fiber core is fixedly connected with the flexible layer at the top of the fluid channel.
4. The microfluidic flow velocity detection device based on the change of the light propagation characteristic according to claim 2, wherein: at the top of the flow channel, the fiber core is in contact with the compliant layer.
5. The microfluidic flow velocity detection device based on the change of the light propagation characteristic according to claim 4, wherein: further comprising a precious metal portion secured to the flexible layer within the fluid channel.
6. The microfluidic flow velocity detection device based on the change in the light propagation characteristic according to claim 5, wherein: the noble metal part is in a strip shape, the strip shape is along the direction of the fiber core, and the noble metal part is in contact with the fiber core.
7. The microfluidic flow velocity detection device based on the change of the light propagation characteristic according to claim 6, wherein: the material of the noble metal part is gold or silver.
8. The microfluidic flow velocity detection device based on the change of the light propagation characteristic according to claim 4, wherein: further comprising precious metal particles affixed to the flexible layer within the fluid channel.
9. The microfluidic flow velocity detection device based on the change in the light propagation characteristic of claim 8, wherein: the noble metal particles are in contact with the fiber core, and the noble metal particles are made of gold or silver.
10. The microfluidic flow velocity detection device based on the change in light propagation property according to any one of claims 1 to 9, wherein: the flexible layer is made of polydimethylsiloxane.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202011206919.8A CN112345792A (en) | 2020-11-03 | 2020-11-03 | Micro-fluidic flow velocity detection device based on light propagation characteristic changes |
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| CN202011206919.8A CN112345792A (en) | 2020-11-03 | 2020-11-03 | Micro-fluidic flow velocity detection device based on light propagation characteristic changes |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114660325A (en) * | 2022-03-21 | 2022-06-24 | 云南师范大学 | Flow velocity detection pipeline based on carbon quantum dots |
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2020
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114660325A (en) * | 2022-03-21 | 2022-06-24 | 云南师范大学 | Flow velocity detection pipeline based on carbon quantum dots |
| CN114660325B (en) * | 2022-03-21 | 2023-08-11 | 云南师范大学 | Flow velocity detection pipeline based on carbon quantum dots |
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