CN112326977A - Full-automatic leucorrhea detector - Google Patents
Full-automatic leucorrhea detector Download PDFInfo
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- CN112326977A CN112326977A CN201910716580.7A CN201910716580A CN112326977A CN 112326977 A CN112326977 A CN 112326977A CN 201910716580 A CN201910716580 A CN 201910716580A CN 112326977 A CN112326977 A CN 112326977A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
Abstract
The invention discloses a fully-automatic leucorrhea detector, and relates to the technical field of medical instruments. The device comprises: the device comprises a sample feeding mechanism, a sample adding needle displacement lifting mechanism, a dry chemical detection mechanism, a morphology detection mechanism and a central control module; the sample feeding mechanism is provided with a pipe rack for containing samples, and the pipe rack is movably arranged; the sample feeding needle displacement lifting mechanism is provided with a sample feeding needle, the sample feeding needle acquires a sample from the pipe rack through the sample feeding needle displacement lifting mechanism, and the sample is respectively sent to the dry chemical detection mechanism and the morphological detection mechanism for detection; the central control module is respectively and electrically connected with the sample feeding mechanism, the sample adding needle displacement lifting mechanism, the dry chemical detection mechanism and the morphology detection mechanism. The device realizes full-automatic integrated detection of dry chemical detection and morphological detection, automatic operation and treatment, and no need of manual intervention.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to a fully-automatic leucorrhea detector.
Background
In the common examination items of gynecological diseases, leucorrhea detection can clarify the cause of vaginal microecosystem disorder. According to the instruction of the article of clinical application expert consensus on vaginal microecological evaluation, published in the journal of Chinese onset obstetrics in 2016 (10 months) by the cooperative group of infectious diseases of the gynecological science Association of the Chinese medical society, the morphological detection and the functional detection are comprehensive, comprehensive and normative methods for evaluating the conditions of the vaginal microecological system, can comprehensively improve the accuracy of leucorrhea result analysis, and provide comprehensive and effective judgment basis for clinical intervention and treatment of vaginal infectious diseases.
At present, people mainly acquire the vaginal microecological condition through the processes of leucorrhea acquisition, on-machine detection, index analysis and the like, but most of the existing detection technologies and detection methods have the following defects: 1. the steps are complicated, the operation process is time-consuming and labor-consuming, and the automation degree is low; 2. the observation results of different individuals are different depending on subjective judgment of human eyes, and great artificial difference exists; 3. cross infection among samples cannot be avoided, and the accuracy is poor. Therefore, how to develop a new type of fully automatic white-band detector to improve the efficiency and accuracy of white-band dry chemical and morphological detection is a technical problem to be solved by those skilled in the art.
Disclosure of Invention
The invention aims to solve the technical problems in the prior art, provides a full-automatic integrated detection device combining dry chemical detection components and morphological detection indexes, and particularly provides a novel white-band full-automatic detector to improve the white-band dry chemical and morphological detection efficiency and accuracy.
In order to solve the problems, the invention adopts the technical scheme that:
a fully automatic white band detector, the device comprising: the device comprises a sample feeding mechanism, a sample adding needle displacement lifting mechanism, a dry chemical detection mechanism, a morphology detection mechanism and a central control module;
the sample feeding mechanism is provided with a pipe rack for containing samples, and the pipe rack is movably arranged; the sample feeding needle displacement lifting mechanism is provided with a sample feeding needle, the sample feeding needle acquires a sample from the pipe rack through the sample feeding needle displacement lifting mechanism, and the sample is respectively sent to the dry chemical detection mechanism and the morphological detection mechanism for detection; the central control module is respectively and electrically connected with the sample feeding mechanism, the sample adding needle displacement lifting mechanism, the dry chemical detection mechanism and the morphology detection mechanism.
The sample feeding mechanism comprises a sample feeding mechanism bottom plate, a sample frame bottom plate, a first touch switch and a sample pushing arm; the sample rack bottom plate is connected with the sample feeding mechanism bottom plate through a support column; the bottom plate of the sample rack is provided with a sample inlet area; the pipe rack can move on the sample rack bottom plate; the first touch switch is arranged on the bottom plate of the sample rack and is electrically connected with the central control module; the sample pushing arm is arranged on the sample rack bottom plate and is electrically connected with the central control module; when the pipe rack is contacted with the first touch switch, the central control module drives the sample pushing arm to push the pipe rack to move towards the sample injection area; the sample adding needle acquires a sample in a tube rack positioned in the sample adding area.
The technical scheme is that the sampling area is also provided with an optical coupler transmitter and an optical coupler receiver, and the optical coupler transmitter and the optical coupler receiver are arranged on two sides through which the pipe rack passes; when the optical coupler transmitter and the optical coupler receiver detect samples in the pipe rack, the central control module controls the sample adding needle to obtain the samples in the pipe rack.
The bottom plate of the sample frame is also provided with a first sensor, a first push rod arm, a second sensor, a second push rod arm and a second touch switch which are all electrically connected with the central control module; the first touch switch and the second touch switch are respectively arranged at two ends of the sample pushing arm in the moving direction; the movement direction of the first push rod arm for pushing the pipe rack is opposite to the movement direction of the second push rod arm for pushing the pipe rack; when the first sensor detects the pipe rack, the central control module drives the first push rod arm to push the pipe rack to move towards the direction of the position of the first touch switch; the central control module also drives the sample pushing arm to push the pipe rack to move from the sample injection area to the direction of the position of the second touch switch; when the pipe rack is contacted with the second touch switch, the central control module drives the second push rod arm to push the pipe rack to move from the direction of the position of the second sensor; when the second sensor detects the pipe rack, the central control module stops driving the second push rod arm.
The sampling needle displacement and lifting mechanism comprises a lifting arm, a first fixing plate, a second fixing plate, a sampling needle pressing plate, a lifting conveying device and a first sliding rail; the first sliding rail is arranged on the lifting arm; the first fixing plate is arranged on the first slide rail and can slide along the first slide rail under the driving of the lifting conveying device; the second fixing plate is fixedly arranged on the first fixing plate; the sample adding needle is connected with the second fixing plate through a sample adding needle pressing plate; the lifting transmission device is electrically connected with the central control module.
The technical scheme is that the sample adding needle displacement lifting mechanism further comprises a displacement arm, a second slide rail and a displacement conveying device; the second slide rail is arranged on the shifting arm; the lifting arm is arranged on the second slide rail and can slide along the second slide rail under the driving of the displacement conveying device; the sample adding positions of the dry chemical detection mechanism and the morphological detection mechanism are arranged below the sample adding needle which moves along the second slide rail; the shift transmission device is electrically connected with the central control module.
The dry-type chemical detection mechanism comprises a card box, a card pushing arm, a card slot, a card feeding cross arm, a card feeding device, an incubation device, a collection determination device and a third slide rail;
the card box is provided with a detection card; the clamping groove is arranged below the sample adding needle moving along the second sliding rail and is connected with the third sliding rail; the third slide rail and the card feeding device are arranged on the card feeding cross arm; the card pushing arm is connected with the card feeding device; the card feeding device is electrically connected with the central control module and driven by the central control module to enable the card pushing arm to slide along the third slide rail so as to push the detected card from the card box to the card slot and then from the card slot to the third slide rail; the incubation device and the acquisition and judgment device are sequentially arranged on the third sliding rail.
The morphology detection mechanism comprises a plate box, a grabbing arm, a plate groove, a plate feeding cross arm, a plate feeding device, a fourth slide rail and a microscopic device;
the plate box is provided with a counting plate; the grabbing arm is electrically connected with the central control module and driven by the central control module to push the counting plate to the plate groove; the fourth slide rail is arranged on the plate feeding cross arm; the plate groove is arranged on the fourth slide rail and can slide to the microscope device along the fourth slide rail under the driving of the plate feeding device.
The device further comprises a cleaning mechanism, wherein the cleaning mechanism comprises washing liquid, a plunger pump and a waste liquid tank;
the washing liquid is communicated with the plunger pump through a hose; the plunger pump is communicated with the sample adding needle through a hose; the waste liquid groove is arranged below the sample adding needle which moves along the second slide rail;
the central control module is electrically connected with the plunger pump;
and a reagent groove is also formed below the sample adding needle moving along the second sliding rail, and a reagent bottle is arranged in the reagent groove.
The card box is further provided with a third sensor, and the third sensor is used for detecting whether a detection card exists in the card box; the plate box is provided with a fourth sensor, and the fourth sensor is used for detecting whether a counting plate exists in the plate box.
Compared with the prior art, the invention can achieve the following technical effects:
the automation degree is high: the device automatically controls the sample feeding mechanism, the sample adding needle displacement lifting mechanism, the dry chemical detection mechanism and the morphology detection mechanism through the central control module, so that full-automatic integrated detection of dry chemical detection and morphology detection is realized, automatic operation and processing are realized, and manual intervention is not needed;
when the sample feeding mechanism moves the pipe rack to a specified position, the sample feeding needle can obtain a sample from the pipe rack through the sample feeding needle displacement lifting mechanism, and the sample is detected by the dry chemical detection mechanism and the morphological detection mechanism;
and (3) rapid detection: by using the fully-automatic leucorrhea detector provided by the invention, dry-type chemical detection of 35-45 samples/hour and morphological detection of 80-100 samples/hour can be realized, the detection of the two samples/hour can be carried out simultaneously, the speed is high, and the detection efficiency is greatly improved;
no cross contamination: dry chemical detection and morphological detection are carried out separately, so that cross contamination is avoided; the safety and effectiveness of the device are guaranteed, the detection efficiency of the sample is improved, the detection accuracy is improved, and the human health and life safety are guaranteed.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings needed to be used in the description of the embodiments are briefly introduced below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without creative efforts.
Fig. 1 is a schematic view of the fully automatic leucorrhea detector of the present invention.
Fig. 2 is a schematic perspective view of the central control module according to the present invention.
Fig. 3 is a schematic perspective view of the sample feeding structure of the present invention.
Fig. 4 is a schematic perspective view of the sample injection needle displacement and lifting mechanism of the present invention.
FIG. 5 is a perspective view of the dry chemical detecting apparatus according to the present invention.
FIG. 6 is a perspective view of the morphological examination device of the present invention.
Fig. 7 is a side perspective view of the fully automatic leucorrhea meter of the present invention.
Fig. 8 is a schematic structural view of a plunger pump device for cleaning a sample injection needle by the fully automatic leucorrhea detector of the present invention.
Fig. 9 is a flow chart of the detection operation by the fully automatic leucorrhea detector of the present invention.
Reference numerals
1 power switch, 2 central control module, 3 power supply, 4 morphology detection device, 5 sample sending mechanism, 6 pipe rack, 7 dry-type chemical detection mechanism, 8 microscopic device, 10 sampling needle displacement lifting mechanism, 11 main control board, 12 plunger pump motor driver, 15 card sending device motor driver, 16 waste liquid tank motor driver, 17 lifting transmission device motor driver, 18 displacement transmission device motor driver, 19 first push rod arm pushing motor driver, 20 plate sending device driver, 21 sample pushing arm pushing motor driver, 22 second push rod arm pushing motor driver, 23 main board support plate, 24 first sensor, 25 first push rod arm, 26 first touch switch, 27 sample pushing arm, 28 optical coupler transmitter, 29 optical coupler receiver, 30 scanner, 31 scanner fixing seat, 32 second push rod arm, 33 second sensor, 34 sample sending mechanism bottom plate, 35 a second touch switch, 36 a bottom plate of a sample rack, 37 a support column, 39 a lifting and conveying device, 40 a pressing plate of a sample adding needle, 41 a second fixing plate, 42 a first fixing plate, 43 a motor of the lifting and conveying device, 44 a lifting arm, 45 a motor of the shifting and conveying device, 46 a shifting arm, 48 the shifting and conveying device, 49 a sample adding needle, 50 a card feeding cross arm, 51 a card feeding device, 52 a collecting and judging device, 53 a hatching device, 54 a card slot, 55 a torsion arm, 56 a third sensor, 57 a card box, 58 a card feeding cross arm, 59 a board feeding device, 60 a fourth sensor, 61 a board box, 62 a 63 a board slot, 64 a board feeding device motor, an optical coupling baffle plate 65, a seventh sensor 66, a spring 67, a torsion rod 68, 74 a reagent slot, 75 a waste liquid slot, 76 a card pushing arm, 77 a washing liquid, 78 a plunger pump, 79 an electromagnetic valve, 80 a water inlet, 81 a water inlet.
Detailed Description
The technical solutions in the embodiments will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, wherein like reference numerals represent like elements in the drawings. It is apparent that the embodiments to be described below are only a part of the embodiments of the present invention, and not all of them. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
It will be understood that the terms "comprises" and/or "comprising," when used in this specification and the appended claims, specify the presence of stated features, integers, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, and/or groups thereof.
It is also to be understood that the terminology used in the description of the embodiments of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the embodiments of the invention. As used in the description of embodiments of the present invention and the appended claims, the singular forms "a," "an," and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise.
Referring to fig. 1 to 7, an embodiment of the present invention provides a fully automatic white band detector, where the fully automatic white band detector includes: the device comprises a sample feeding mechanism 5, a sample adding needle displacement lifting mechanism 10, a dry chemical detection mechanism 7, a morphology detection mechanism 4 and a central control module 2; the sample feeding mechanism 5 is provided with a pipe rack 6 for containing samples, and the pipe rack 6 is movably arranged; the sample adding needle displacement and lifting mechanism 10 is provided with a sample adding needle 49, the sample adding needle 49 obtains a sample from the pipe rack 6 through the sample adding needle displacement and lifting mechanism, and the sample is respectively sent to the dry-type chemical detection mechanism 7 and the morphological detection mechanism 4 for detection; the central control module 2 is electrically connected with the sample feeding mechanism 5, the sample adding needle displacement lifting mechanism 10, the dry chemical detection mechanism 7 and the morphology detection mechanism 4 respectively.
Specifically, the prior international 5 x 10 calandria is adopted for sample injection, and no additional pipe rack is needed.
The device has the following technical effects:
the automation degree is high: the central control module is used for automatically controlling the sample feeding mechanism, the sample adding needle shifting and lifting mechanism, the dry chemical detection mechanism and the morphology detection mechanism, so that full-automatic integrated detection of dry chemical detection and morphology detection is realized, automatic operation and processing are realized, and manual intervention is not needed; when the sample feeding mechanism moves the pipe rack to a specified position, the sample adding needle 49 can obtain a sample from the pipe rack through the sample adding needle displacement lifting mechanism, and the sample is detected by the dry chemical detection mechanism and the morphological detection mechanism;
and (3) rapid detection: by using the fully-automatic leucorrhea detector provided by the invention, dry-type chemical detection of 35-45 samples/hour and morphological detection of 80-100 samples/hour can be realized, the detection of the two samples/hour can be carried out simultaneously, the speed is high, and the detection efficiency is greatly improved;
no cross contamination: dry chemical detection and morphological detection are carried out separately, so that cross contamination is avoided; the safety and effectiveness of the device are guaranteed, the detection efficiency of the sample is improved, the detection accuracy is improved, and the human health and life safety are guaranteed.
In one embodiment, with continued reference to fig. 3, the sample feeding mechanism 5 includes a sample feeding mechanism bottom plate 34, a sample rack bottom plate 36, a first trigger switch 26 and a sample pushing arm 27; the sample rack bottom plate 34 is connected with the sample feeding mechanism bottom plate 34 through a support column 37; the sample holder bottom plate 34 is provided with a sample inlet area; the rake 6 is movable on the sample holder floor; the first touch switch is arranged on the bottom plate of the sample rack and is electrically connected with the central control module; the sample pushing arm 27 is arranged on the bottom plate of the sample rack and is electrically connected with the central control module; when the pipe rack 6 contacts with the first touch switch, the central control module drives the sample pushing arm 27 to push the pipe rack 6 to move towards the sample injection area, and the sample injection needle 49 acquires a sample in the pipe rack 6 located in the sample injection area.
In this embodiment, the sample feeding mechanism can realize that the pipe rack moves to the sample injection area automatically, and the sample injection needle is controlled by the central control module to obtain the sample in the pipe rack in the sample injection area, so as to realize the function of automatic sampling.
In one embodiment, the sample introduction area is further provided with an optical coupler transmitter 28 and an optical coupler receiver 29, and the optical coupler transmitter 28 and the optical coupler receiver 29 are arranged on two sides through which the pipe rack 6 passes; when the optical coupler transmitter 28 and the optical coupler receiver 29 detect the samples in the pipe rack 6, the central control module controls the sample adding needle 49 to obtain the samples in the pipe rack 6.
Whether this embodiment detects the sample on the pipe rack through advancing the appearance district by the optical axis that the opto-coupler transmitter 28 and the opto-coupler receiver 29 of correlation opto-coupler formed, and the pipe rack that contains the sample passes through, can block the optical axis to drive the application of sample needle for control center module and acquire the sample in the pipe rack and reserve certain time, the application of sample needle of being convenient for carries out normal sampling operation.
In another embodiment, the sample introduction region is further provided with a scanner 30. The scanner 30 is disposed at the scanner fixing base 31. The test tube that is used for the splendid attire sample is established to pipe rack 6, and the test tube surface is pasted the bar code with sample patient information, scanner 30 acquires sample patient information transmission to computer through the scanning bar code to carry out automatic matching with testing result and patient.
In one embodiment, the sample holder bottom plate is further provided with a first sensor, a first push rod arm, a second sensor 33, a second push rod arm 32 and a second touch switch 35 which are all electrically connected with the central control module; the first touch switch and the second touch switch 35 are respectively arranged at two ends of the sample pushing arm 27 in the moving direction; the direction of movement of the first pusher arm pushing the rake 6 is opposite to the direction of movement of the second pusher arm 32 pushing the rake 6;
when the first sensor detects the pipe rack 6, the central control module drives the first push rod arm to push the pipe rack 6 to move towards the direction of the position of the first touch switch; the central control module also drives the sample pushing arm 27 to push the pipe rack 6 to move from the sample inlet area to the direction of the position of the second touch switch 35; when the pipe rack 6 is in contact with the second trigger switch 35, the central control module drives the second push rod arm 32 to push the pipe rack 6 to move in the direction from the position of the second sensor 33; when the second sensor 33 detects the rake 6, the central control module stops driving the second pusher arm 32.
In the embodiment, the invention can be matched with international 5 × 10 calandria, after the 5 × 10 calandria is placed on the bottom plate of the sample rack, the sample feeding mechanism can automatically move the pipe rack 6, take samples, move the pipe rack 6 out of the sample entering area, and automatically operate in cycles, and only the pipe rack 6 needs to be placed in and taken out manually, so that the efficiency is greatly improved.
In one embodiment, the sample injection needle displacement and lifting mechanism includes a lifting arm 44, a first fixing plate 42, a second fixing plate 41, a sample injection needle pressing plate 40, a lifting and conveying device 39, and a first slide rail; the lifting arm 44 is vertically arranged; the first slide rail is arranged on the lifting arm 44; the first fixing plate 42 is disposed on the first slide rail and can slide along the first slide rail under the driving of the lifting and conveying device 39; the second fixing plate 41 is fixedly arranged on the first fixing plate 42; the sample adding needle 49 is connected with the second fixing plate 41 through a sample adding needle pressing plate 40; the lifting conveyor 39 is electrically connected to the central control module.
This embodiment can realize the vertical direction motion of application of sample needle through application of sample needle aversion elevating system to control application of sample needle vertical downstream to advancing the district in order to obtain the sample. The lifting and conveying device 39 is provided with a lifting motor 43, and the central control module drives the lifting motor to control the vertical movement of the sample adding needle.
In one embodiment, the sample injection needle displacement lifting mechanism further includes a displacement arm 46, a second slide rail, and a displacement conveying device 48; the second slide rail is disposed on the shift arm 46; the displacement arm 46 is longitudinally disposed; the lifting arm 44 is disposed on the second slide rail and can slide along the second slide rail under the driving of the shift transmission device 48; the displacement transmission device 48 is electrically connected with the central control module; when the lifting arm 44 moves along the second slide rail, the loading needle 49 can be driven to move along the second slide rail, so that the loading needle 49 can move longitudinally.
This embodiment can realize application of sample needle longitudinal movement through application of sample needle aversion elevating system, and application of sample needle acquires can deliver to dry-type chemical detection mechanism and morphology detection mechanism respectively with the sample after the sample. The sample adding position where the dry chemical detection mechanism and the morphological detection mechanism receive the sample is arranged below the longitudinal movement of the sample adding needle, so that the sample is conveniently dripped into the sample adding needle.
In one embodiment, the dry chemical detection mechanism includes a card box 57, a factory-shaped card pushing arm 76, a card slot 54, a card feeding cross arm 50, a card feeding device 51, an incubation device 53, a collection determination device 52, and a third slide rail; the card box 57 is provided with a detection card; the clamping groove 54 is arranged below the sample adding needle 49 which moves along the second sliding rail, and the clamping groove 54 is connected with the third sliding rail;
the third slide rail and the card feeding device 51 are arranged on the card feeding cross arm 50;
the card pushing arm 76 is connected with the card feeding device 51;
the card feeding device 51 is electrically connected with the central control module and driven by the central control module to enable the card pushing arm 76 to slide along the third slide rail, so that the detection card is pushed from the card box 57 to the card slot 54 and then pushed from the card slot 54 to the third slide rail;
pushing the test card to the card slot 54; the clamping groove 54 is arranged below the sample adding needle moving along the second slide rail and is connected with the third slide rail; the incubation device and the acquisition and judgment device are sequentially arranged on the third sliding rail.
The card pushing arm 76 pushes the detection card out of the card slot 54 to the third slide rail and pushes the detection card to slide along the third slide rail, and the detection card sequentially goes to the incubation device 53 and the collection determination device 52.
After the sample is obtained by the sample adding needle, the sample is dripped into the detection card of the card slot 54; the sample addition needle 49 also takes in the reagent bottle and reacts the reagent with the sample. It can be understood that the reagent bottle is disposed below the sampling needle 49 moving along the second slide rail, and the moving track of the sampling needle 49 is reasonably utilized. The card feeding device 51 drives the card pushing arm 76 to feed the detection card to the incubation device 53 along the third slide rail for incubation at 42 ℃ for 10min, so as to accelerate the color development process and enable the detection area of the detection card sample to display different colors; the incubation device 53 is provided with a fifth sensor, so that the detection card is accurately detected and heated at the incubation device 53; the card feeding device 51 is installed on the card feeding cross arm 50, after incubation is completed, the card feeding device 51 drives the card pushing arm 76 again to convey the detection card to the acquisition and judgment device 52 along the third sliding rail, and the color of the detection area of the detection card is received by the detector, and the light quantity value of the color reflection light is obtained by the color sensor to analyze and judge the result. A blank control hole is arranged on the detection card and is used for eliminating the nonspecific color development of the sample. And comparing the light quantity value of the reflected light of each detection area on the detection card with the reflected light quantity value of the blank control hole, and calculating to obtain a difference value. The dry chemical detection mechanism is connected with a computer, and can automatically determine whether each dry chemical index of the detection card is negative or positive according to the difference value of the detection result and a preset determination standard, for example, automatically determine the result of the sample as negative, weak positive, positive and strong positive according to the detection result and the determination standard.
The dry-type chemical detection mechanism that this embodiment provided can realize hatching the sample automatically, automated inspection's effect, has avoided the error of artificial judgement, improves the accuracy of testing result.
In one embodiment, the morphology detection mechanism comprises a plate box 61, a grabbing arm 62, a plate slot 63, a plate feeding cross arm 58, a plate feeding device 59, a fourth slide rail and a microscope device 8; the plate box 61 is provided with a counting plate; the grabbing arm 62 is electrically connected with the central control module and driven by the central control module to push the counting plate to the plate groove 63; the sample adding position of the plate groove 63 is arranged below the sample adding needle moving along the second slide rail; the fourth slide rail is arranged on the plate feeding cross arm 58; the plate groove 63 is disposed on the fourth slide rail and can slide to the microscope device 8 along the fourth slide rail under the driving of the plate feeding device 59, so as to feed the counting plate to the microscope device 8.
It will be appreciated that plate feeding device 59 is connected to microscope device 8 by a fourth slide rail along which the counter plate slides with plate channel 63 to microscope device 8.
In other embodiments, the position of the microscope device 8 for receiving the counting plate is an object stage, a sixth sensor is disposed on one end of the microscope device 8 of the fourth slide rail, and when the sixth sensor detects that the plate slot 63 arrives, a signal is sent to the central control module, and the central control module sends an instruction to control the plate feeding device 59 to stop moving.
In this embodiment, after the sample is added to the counting plate, the plate feeding device 59 continues to transfer the counting plate in the plate groove 63 to the stage position of the microscope device 8 for microscopic examination. The microscopic examination process can be performed manually or by using a microscope device with an automatic focusing function, which is not described in detail herein.
It can be understood that the dry chemical detection mechanism and the morphological detection mechanism are arranged in parallel, and the sample adding positions of the card slot 54 and the plate slot 63 are arranged in parallel below the sample adding needle moving along the second slide rail; therefore, after the sample is obtained by the sample adding needle 49, the sample can be respectively dripped on the detection card and the counting plate, so that the sample can be simultaneously subjected to dry chemical detection and morphological detection.
In one embodiment, the fully automatic leucorrhea meter further comprises a cleaning mechanism, wherein the cleaning mechanism comprises a washing liquid 77, a plunger pump 78 and a waste liquid tank 75; the washing liquid 77 is communicated with a plunger pump 78 through a hose; the plunger pump 78 is communicated with the sample adding needle 49 through a hose; the waste liquid groove 75 is arranged below the sample adding needle moving along the second slide rail; the central control module 2 is electrically connected to the plunger pump 78.
Specifically, a waste liquid tank 75 and a reagent tank 74 are arranged below the sample adding needle 49 moving along the second slide rail; the reagent tank 74 is provided with a reagent bottle. After the sample is added to the detection card and the counting plate by the sample adding needle 49, the sample can be automatically cleaned by moving the sample adding needle to the waste liquid tank 75 through the sample adding needle displacement and lifting mechanism. The sample adding needle 49 is used for obtaining a reagent in the reagent bottle and dripping the reagent into the detection card, so that the reagent and the sample are subjected to color reaction, and dry chemical detection is carried out. Through the processes of loading, cleaning, reagent loading and cleaning, the cross contamination among different samples, different reagents and samples and reagents is avoided, and the accuracy of the inspection result is ensured.
As shown in fig. 8, the cleaning mechanism further includes a solenoid valve 79, a plunger pump motor 83; the plunger pump motor 83 and the electromagnetic valve 79 are respectively connected with the plunger pump 78; the solenoid valve 79 is provided with a water inlet 80, a water outlet 82, and a water supply hole 81.
The cleaning mechanism cleans the sample adding needle 49 as follows:
when the plunger pump motor 83 operates, the screw rod of the plunger pump motor 83 drives the plunger of the plunger pump 77 to reciprocate up and down. When the plunger pump motor 83 drives the plunger to move downwards, the water inlet hole 80 is communicated with the water outlet hole 82, the washing liquid 77 can enter the plunger pump 78 through the communicated water inlet hole 80 and the communicated water outlet hole 82, and when the plunger moves to the lower dead point, water inlet is finished.
When the sampling needle 49 needs to be cleaned, the plunger pump motor 83 drives the plunger to move upwards, the washing liquid in the upper space of the plunger pumps out the plunger pump 78 under the pressure of the plunger, meanwhile, the central control module 2 sends out a signal to enable the water outlet hole 82 and the water feeding hole 81 to be communicated, the washing liquid 77 enters the rubber tube connected with the upper end of the sampling needle 49 through the communicated water outlet hole 82 and the water feeding hole 81 and enters the sampling needle 49, and therefore the sampling needle 49 is cleaned. After the cleaning, the waste liquid after cleaning the loading needle 49 is directly discharged into the waste liquid tank 75. Cleaning of the sampling needle 49 is completed.
In other embodiments, the washing mechanism further comprises a liquid discharge mechanism comprising a waste liquid tank motor (not shown) and a peristaltic pump (not shown); the waste liquid tank motor is connected with a peristaltic pump, and the peristaltic pump is connected with the waste liquid tank 75; the central control module 2 is connected with a waste liquid tank motor.
Specifically, the waste liquid tank 75 is used for containing waste liquid which is washed by the sampling needle 49, the sampling needle 49 moves to the waste liquid tank 75, and the plunger pump motor 83 drives the plunger pump 78 to enable the washing liquid 77 to wash the sampling needle 49; the waste liquid tank 75 is connected with a hose, and the central control module 2 drives the waste liquid tank motor to drive the peristaltic pump so as to discharge waste liquid out of the device through the hose.
It is understood that in other embodiments, other mechanisms for draining the waste fluid from the waste fluid tank may be used and are within the scope of the present invention.
It should be noted that, when the sample adding needle 49 needs to be loaded after being cleaned, the plunger pump motor 83 drives the plunger in the plunger pump 78 to move downward for a short distance according to the set number of steps, the washing liquid in the hose flows back to the plunger, and meanwhile, the hose sucks in a certain amount of air through the sample adding needle. The central control module 2 sends out an execution operation signal, the sample adding needle 49 starts to suck samples under the influence of the pressure difference between the inside and the outside of the plunger pump 78, and the volume of the sucked samples is the volume of the quantitative air, so that the sample amount added into each detection hole of the detection card can be kept consistent. After the sample adding needle 49 adds the sample into the detection hole, the central control module 2 sends out the execution signal again to drive the process of cleaning the sample adding needle 49. The solenoid valve 79 communicates with the sampling needle 49 through a hose.
When the system is started to operate, the central control module 2 firstly sends an instruction to circularly clean the pipeline passage of the whole system for 3-5 times, so that the cross contamination of a fresh sample is avoided. The accuracy of the detection result is ensured.
In an embodiment, a reagent groove 74 is further disposed below the sample adding needle moving along the second slide rail, and a reagent bottle (not shown) is disposed in the reagent groove 74. It can be understood that, in order to facilitate the movement of the loading needle 49, the reagent tank 74 and the waste liquid tank 75 are both disposed on the same straight line below the second slide rail along which the loading needle moves.
In other embodiments, the reagent bottle has a suction nozzle, the sample adding needle 49 is sleeved in the suction nozzle to obtain the reagent, and the reagent is added dropwise to the detection card through the suction nozzle, after the reagent is added dropwise, the sample adding needle 49 returns to the reagent tank 74, and the suction nozzle is pushed away from the sample adding needle 49 by the twisting mechanism, so that the suction nozzle falls back to the reagent bottle in the reagent tank 74.
The twisting mechanism is provided in the card feeder 51. The card feeding device 51 further comprises a motor, a synchronous belt, a seventh sensor 66 and an optical coupling baffle 65; the central control module controls the working state of the motor; the motor drives the synchronous belt to move, the card pushing arm 76 is connected with the synchronous belt, and the card pushing arm 76 pushes the detection card to slide along the third sliding rail under the driving of the motor; the optical coupling catch 65 is connected with the synchronous belt and moves along with the synchronous belt; the seventh sensor 66 is disposed on the card-feeding cross arm 50 and located below the sample-adding needle moving along the second slide rail.
The torsion mechanism includes a torsion arm 55, a torsion shaft, a torsion bar 68, and a spring 67; torsion arm 55 is connected to torsion bar 68 by a torsion shaft; one end of the spring 67 is connected with the torsion shaft, and the other end is connected with the card feeding device 51; the torsion arm 55 is disposed below the movement of the sample injection needle along the second slide rail, and the initial position of the torsion rod 68 is also located below the movement of the sample injection needle along the second slide rail and transversely spans the movement direction of the optical coupling blocking piece 65. It will be appreciated that when the torsion bar 68 is in the initial position, the torsion arms 55 are in the open state.
The central control module drives a motor at the card feeding device to work, and when the motor drives a synchronous belt to move, the synchronous belt drives the card pushing arm 76 and the optical coupling blocking piece 65 to move. When the optical coupling blocking piece 65 moves towards the seventh sensor 66, the torsion rod 68 originally transversely extending in the movement direction of the optical coupling blocking piece 65 is instantly extruded to the periphery of the optical coupling blocking piece 65, the seventh sensor 66 receives a signal of the optical coupling blocking piece 65 and then sends a signal to the central control module, the motor is controlled to stop acting, so that the optical coupling blocking piece 65 stops moving, and the torsion arm 55 is driven to close by the torsion shaft when the torsion rod 68 is extruded to the periphery of the optical coupling blocking piece 65; when the opto-coupler separation blade 65 retreats under motor drive, originally, torsion bar 68 at the periphery of opto-coupler separation blade 65 is gradually pulled back by spring 67, make torsion bar 68 return initial position under the effect of spring 67, opto-coupler separation blade 65 passes through seventh sensor 66 when retreating under motor drive, seventh sensor 66 receives the signal and then sends a signal to central control module, thereby control motor stops the action and makes opto-coupler separation blade 65 stop motion, torsion bar 68 returns initial position and drives torsion arm 55 through the torsion shaft and opens.
The skilled person can implement automatic dropping of the reagent by other existing mechanisms, and the present invention is not limited in this regard.
In one embodiment, the cartridge 57 is provided with a third sensor 56, the third sensor 56 being used to detect whether a detection card is present in the cartridge 57; the plate box 61 is provided with a fourth sensor 60, and the fourth sensor 60 is used for detecting whether a counting plate exists in the plate box 61.
In this embodiment, when the third sensor 56 detects that there is no detection card in the card box 57, it will automatically send an alarm prompt to remind the user to add a detection card into the card box 57; similarly, when the fourth sensor 60 detects that no counting plate is in the plate box 61, an alarm prompt is automatically sent to remind a user to add a counting plate into the plate box 61;
in an embodiment, the central control module 2 includes a main control board 11 and a motor driver to realize the coordinated operation of an automatic control sample feeding mechanism, a sample feeding needle displacement and lifting mechanism, a dry chemical detection mechanism and a morphological detection mechanism. Wherein the motor driver is different according to the part that the motor controlled, include:
a plunger pump motor driver 12; the plunger pump motor 83 is driven to operate, and the washing liquid 77 is sent to the sample adding needle 49 through the hose by the cooperation of the electromagnetic valve 79 and the plunger pump 78, so that the sample adding needle 49 completes the automatic cleaning operation. A card feeding device motor driver 15 for driving the motor at the card feeding device to operate, so as to slide the card slot 54 along the third slide rail;
a waste liquid tank motor driver 16 for driving the waste liquid tank motor to discharge the waste liquid having washed the sampling needle;
the lifting and conveying device motor driver 17 is used for driving a lifting and conveying device motor 43 so as to drive the sample adding needle to slide along the first sliding rail;
the displacement conveying device motor driver 18 is used for driving a displacement conveying device motor 45 so as to drive the lifting arm 44 to drive the sample adding needle to slide along the second sliding rail;
the first push rod arm pushing motor driver 19 is used for driving the first push rod arm to push the pipe rack 6 to move towards the direction of the first touch switch position;
the plate conveying device driver 20 is used for driving the plate conveying device motor 64 to operate so as to slide the plate groove 63 along the fourth slide rail;
the sample pushing arm pushing motor driver 21 is used for driving the sample pushing arm 27 to push the pipe rack 6 to move towards the sample injection area and driving the sample pushing arm 27 to push the pipe rack 6 to move from the sample injection area to the direction of the position of the second touch switch 35;
the second pushing arm pushing motor driver 22 is used for driving the second pushing arm 32 to push the pipe rack 6 to move in the direction of the position of the second sensor 33.
Further, the central control module 2 is mounted on the main board support plate 23.
It can be understood that the fully automatic white-band detector provided by the embodiment controls the on-off of the power supply 3 by the operation of the power switch 1 by the inspector to control the working state of the device. The setting of the power switch 1 and the power supply 3 can be designed and selected by those skilled in the art according to the actual requirements, and the invention is not limited to this.
Referring to fig. 9, when the fully automatic leucorrhea test apparatus provided in this embodiment is used for testing a sample of a body fluid, the tester only needs to perform the following simple operations:
(1) sequentially placing test tubes with samples into a pipe rack by a detection worker, and placing the pipe rack in a first sensor area of a bottom plate of the sample rack;
(2) the detection personnel puts the detection card and the counting plate into corresponding card boxes and plate boxes;
the device automatically pushes the detection card and the counting plate out of the lofting positions of the dry chemical detection mechanism and the morphological detection mechanism respectively, and samples in the sample feeding area are automatically dripped into the detection card and the counting plate after being obtained by the sample feeding needle; the sample adding needle also quantitatively obtains a color developing reagent in the reagent bottle and adds the color developing reagent to a detection area of the detection card and the counting plate; then dry chemical detection and morphological detection are respectively carried out on the detection card and the counting plate by a dry chemical detection mechanism and a morphological detection mechanism; and automatically transmitting the detection result to a computer;
(3) the detection personnel enters a software test interface of a computer control system, an execution program is set, and the device automatically scans the calandria detection sample;
(4) the test person enters patient information, confirms the test results transmitted by the device, edits the test results in the selected list, and prints the results.
Therefore, the fully-automatic leucorrhea detector provided by the embodiment of the invention has high automation degree, no manual intervention exists in the detection process, errors of manual detection judgment are avoided, and the accuracy of the detection result is ensured; the dry chemical detection and the morphological detection can be carried out simultaneously, and the detection efficiency is improved.
While the invention has been described with reference to specific embodiments thereof, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined by the appended claims. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.
Claims (10)
1. A fully automatic leucorrhea tester, characterized in that said tester comprises: the device comprises a sample feeding mechanism, a sample adding needle displacement lifting mechanism, a dry chemical detection mechanism, a morphology detection mechanism and a central control module;
the sample feeding mechanism is provided with a pipe rack for containing samples, and the pipe rack is movably arranged; the sample feeding needle displacement lifting mechanism is provided with a sample feeding needle, the sample feeding needle acquires a sample from the pipe rack through the sample feeding needle displacement lifting mechanism, and the sample is respectively sent to the dry chemical detection mechanism and the morphological detection mechanism for detection;
the central control module is respectively and electrically connected with the sample feeding mechanism, the sample adding needle displacement lifting mechanism, the dry chemical detection mechanism and the morphology detection mechanism.
2. The fully automatic leucorrhea tester according to claim 1, characterized in that: the sample conveying mechanism comprises a sample conveying mechanism bottom plate, a sample frame bottom plate, a first touch switch and a sample pushing arm; the sample rack bottom plate is connected with the sample feeding mechanism bottom plate through a support column; the bottom plate of the sample rack is provided with a sample inlet area;
the pipe rack can move on the sample rack bottom plate;
the first touch switch is arranged on the bottom plate of the sample rack and is electrically connected with the central control module;
the sample pushing arm is arranged on the sample rack bottom plate and is electrically connected with the central control module; when the pipe rack is contacted with the first touch switch, the central control module drives the sample pushing arm to push the pipe rack to move towards the sample injection area; the sample adding needle acquires a sample in a tube rack positioned in the sample adding area.
3. The fully automatic leucorrhea detector according to claim 2, wherein said sample introduction area is further provided with an opto-coupler transmitter and an opto-coupler receiver, said opto-coupler transmitter and said opto-coupler receiver being disposed on both sides of the passing through of the rack; when the optical coupler transmitter and the optical coupler receiver detect samples in the pipe rack, the central control module controls the sample adding needle to obtain the samples in the pipe rack.
4. The automatic leucorrhea tester as claimed in claim 3, wherein said sample holder base plate further comprises a first sensor, a first push lever arm, a second sensor, a second push lever arm and a second trigger switch all electrically connected to said central control module;
the first touch switch and the second touch switch are respectively arranged at two ends of the sample pushing arm in the moving direction;
the movement direction of the first push rod arm for pushing the pipe rack is opposite to the movement direction of the second push rod arm for pushing the pipe rack;
when the first sensor detects the pipe rack, the central control module drives the first push rod arm to push the pipe rack to move towards the direction of the position of the first touch switch;
the central control module also drives the sample pushing arm to push the pipe rack to move from the sample injection area to the direction of the position of the second touch switch;
when the pipe rack is contacted with the second touch switch, the central control module drives the second push rod arm to push the pipe rack to move from the direction of the position of the second sensor;
when the second sensor detects the pipe rack, the central control module stops driving the second push rod arm.
5. The automatic leucorrhea detecting instrument according to claim 4, wherein said sample loading needle displacement and lifting mechanism comprises a lifting arm, a first fixing plate, a second fixing plate, a sample loading needle pressing plate, a lifting and conveying device, a first slide rail;
the first sliding rail is arranged on the lifting arm; the first fixing plate is arranged on the first slide rail and can slide along the first slide rail under the driving of the lifting conveying device;
the second fixing plate is fixedly arranged on the first fixing plate; the sample adding needle is connected with the second fixing plate through a sample adding needle pressing plate;
the lifting transmission device is electrically connected with the central control module.
6. The automatic leucorrhea tester as claimed in claim 5, wherein said sample loading needle displacement and elevation mechanism further comprises a displacement arm, a second slide rail, a displacement transmission device;
the second slide rail is arranged on the shifting arm; the lifting arm is arranged on the second slide rail and can slide along the second slide rail under the driving of the displacement conveying device; the sample adding positions of the dry chemical detection mechanism and the morphological detection mechanism are arranged below the sample adding needle which moves along the second slide rail;
the shift transmission device is electrically connected with the central control module.
7. The fully automatic leucorrhea detection apparatus according to claim 6, wherein said dry chemical detection mechanism comprises a card box, a card pushing arm, a card slot, a card feeding cross arm, a card feeding device, an incubation device, a collection determination device, a third slide rail;
the card box is provided with a detection card; the clamping groove is arranged below the sample adding needle moving along the second sliding rail and is connected with the third sliding rail;
the third slide rail and the card feeding device are arranged on the card feeding cross arm;
the card pushing arm is connected with the card feeding device;
the card feeding device is electrically connected with the central control module and driven by the central control module to enable the card pushing arm to slide along the third slide rail so as to push the detected card from the card box to the card slot and then from the card slot to the third slide rail;
the incubation device and the acquisition and judgment device are sequentially arranged on the third sliding rail.
8. The fully automatic leucorrhea testing apparatus of claim 7 wherein said morphological testing mechanism comprises a plate cassette, a grasping arm, a plate slot, a plate feeding crossbar, a plate feeding device, a fourth slide rail, a microscopic device;
the plate box is provided with a counting plate; the grabbing arm is electrically connected with the central control module and driven by the central control module to push the counting plate to the plate groove;
the fourth slide rail is arranged on the plate feeding cross arm; the plate groove is arranged on the fourth slide rail and can slide to the microscope device along the fourth slide rail under the driving of the plate feeding device.
9. The automatic leucorrhea tester according to claim 1, further comprising a cleaning mechanism, said cleaning mechanism comprising a washing liquid, a plunger pump and a waste liquid tank;
the washing liquid is communicated with the plunger pump through a hose; the plunger pump is communicated with the sample adding needle through a hose; the waste liquid groove is arranged below the sample adding needle which moves along the second slide rail;
the central control module is electrically connected with the plunger pump;
and a reagent groove is also formed below the sample adding needle moving along the second sliding rail, and a reagent bottle is arranged in the reagent groove.
10. The automatic leucorrhea detecting apparatus of claim 7 or 8 wherein said cartridge is provided with a third sensor for detecting the presence of a detection card within said cartridge; the plate box is provided with a fourth sensor, and the fourth sensor is used for detecting whether a counting plate exists in the plate box.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910716580.7A CN112326977A (en) | 2019-08-05 | 2019-08-05 | Full-automatic leucorrhea detector |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910716580.7A CN112326977A (en) | 2019-08-05 | 2019-08-05 | Full-automatic leucorrhea detector |
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| CN112326977A true CN112326977A (en) | 2021-02-05 |
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| CN201910716580.7A Pending CN112326977A (en) | 2019-08-05 | 2019-08-05 | Full-automatic leucorrhea detector |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114966072A (en) * | 2022-08-02 | 2022-08-30 | 深圳市瑞图生物技术有限公司 | Gynecological sample analyzer and gynecological sample analysis method |
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2019
- 2019-08-05 CN CN201910716580.7A patent/CN112326977A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114966072A (en) * | 2022-08-02 | 2022-08-30 | 深圳市瑞图生物技术有限公司 | Gynecological sample analyzer and gynecological sample analysis method |
| CN114966072B (en) * | 2022-08-02 | 2022-11-18 | 深圳市瑞图生物技术有限公司 | Gynecological sample analyzer and gynecological sample analysis method |
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