CN112295620A - Saliva draws crystallization micro-fluidic chip fast - Google Patents
Saliva draws crystallization micro-fluidic chip fast Download PDFInfo
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- CN112295620A CN112295620A CN202011084434.6A CN202011084434A CN112295620A CN 112295620 A CN112295620 A CN 112295620A CN 202011084434 A CN202011084434 A CN 202011084434A CN 112295620 A CN112295620 A CN 112295620A
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- sampling
- saliva
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- chip
- crystallization
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- 210000003296 saliva Anatomy 0.000 title claims abstract description 60
- 238000002425 crystallisation Methods 0.000 title claims abstract description 38
- 230000008025 crystallization Effects 0.000 title claims abstract description 36
- 238000005070 sampling Methods 0.000 claims abstract description 74
- 239000007788 liquid Substances 0.000 claims abstract description 42
- 238000010521 absorption reaction Methods 0.000 claims abstract description 26
- 238000001514 detection method Methods 0.000 claims abstract description 16
- 239000012528 membrane Substances 0.000 claims abstract description 15
- 239000000872 buffer Substances 0.000 claims abstract description 3
- 239000010408 film Substances 0.000 claims description 34
- 239000000463 material Substances 0.000 claims description 10
- 239000007853 buffer solution Substances 0.000 claims description 6
- 239000007787 solid Substances 0.000 claims description 5
- 239000010409 thin film Substances 0.000 claims description 4
- 229920000620 organic polymer Polymers 0.000 claims description 3
- 238000007789 sealing Methods 0.000 claims description 3
- 238000000605 extraction Methods 0.000 claims 5
- GQWNECFJGBQMBO-UHFFFAOYSA-N Molindone hydrochloride Chemical compound Cl.O=C1C=2C(CC)=C(C)NC=2CCC1CN1CCOCC1 GQWNECFJGBQMBO-UHFFFAOYSA-N 0.000 claims 1
- 239000002250 absorbent Substances 0.000 claims 1
- 238000011109 contamination Methods 0.000 claims 1
- 230000016087 ovulation Effects 0.000 abstract description 13
- 238000005213 imbibition Methods 0.000 abstract description 8
- 230000010354 integration Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 description 17
- 239000013078 crystal Substances 0.000 description 10
- 210000003756 cervix mucus Anatomy 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 238000010586 diagram Methods 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 238000001914 filtration Methods 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 238000012544 monitoring process Methods 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 241001494479 Pecora Species 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000036760 body temperature Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical class C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 1
- 239000000262 estrogen Substances 0.000 description 1
- 229940011871 estrogen Drugs 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000010794 food waste Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000027758 ovulation cycle Effects 0.000 description 1
- 239000000583 progesterone congener Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 239000012536 storage buffer Substances 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
A micro-fluidic chip for quickly extracting and crystallizing saliva is composed of a chip main body and a sampling pool cover. The chip main body comprises a sampling pool, a liquid absorption film, a liquid storage pool for storing buffer liquid, a sliding groove matched with a sampling pool cover, a microfluid channel, a crystallization pool and an air vent. The air vent is located crystallization tank one end, and microfluid passageway intercommunication sampling pool and crystallization tank, imbibition membrane divide into upper and lower two parts with the sampling pool, and the liquid reserve tank is located the sampling pool upside and separates through film and sampling pool, and the spout is located the relative one side of liquid reserve tank, communicates sampling pool and chip edge, and the spout both sides are equipped with spacing spout. One side of the sampling pool cover is provided with a needle-shaped structure, and two sides of the sampling pool cover are provided with limiting columns. This chip simple structure utilizes the imbibition membrane to realize the integration operation that saliva was gathered, was filtered, was drawed, compares in saliva detection chip on the market, when saliva collection efficiency promoted, can obtain purer saliva crystallization. The speed and the accuracy of ovulation saliva detection are improved by matching with a matched detection instrument.
Description
Technical Field
The invention relates to the technical field of microfluidic medical detection, in particular to a saliva sample injection crystallization microfluidic device.
Background
At present, methods for detecting ovulation of women of childbearing age mainly comprise: calendar method, basic body temperature method, cervical mucus method, B ultrasonic method and ovulation test paper method. The calendar method has low accuracy, the basic body temperature method has too many limiting conditions, the examinees of the cervical mucus method and the B ultrasonic method have to go to the hospital, the operation is inconvenient, much time is spent, and the ovulation test paper method is not as convenient as the sampling of the saliva crystallization method.
The saliva crystallization method is a method for monitoring female ovulation by utilizing the crystal form and cycle consistency of saliva and cervical mucus. Through extensive experiments, it is verified that the salivary crystal change of women is closely related to the menstrual cycle stage like cervical mucus. This is a result of the interaction of the contents of sodium chloride, protein and water in the cervical mucus with the variation of the estrogen and progestin at a certain ratio. Saliva also contains the three main components. The change is specifically shown as about 7 days before the ovulation day, and sheep tooth crystals and normal spots can appear in saliva and are mixed until the ovulation day is the clearest and most typical. After ovulation, the crystals gradually blur and disappear. Therefore, whether the female enters the ovulation stage or not can be judged according to the crystallization condition of the sheep teeth appearing in saliva.
Most of the currently marketed saliva crystal ovulation monitoring products take the saliva crystal ovulation monitoring products as the detection principle, saliva is directly coated on a glass slide after being collected, the result is easily influenced by food residues and bubbles, if people eat the saliva, the people need to rinse the mouth and wait for 1 hour before taking the saliva, and the mode of collecting the saliva from the mouth easily causes psychological discomfort of users in public places and seriously influences the use convenience; even the collector with the filter screen structure still can not guarantee to obtain the saliva crystal of relative purity. The difference of the thickness of the saliva film has obvious influence on the crystallization effect; meanwhile, for the image shooting type ovulation detector, the saliva amount and the crystallization position are difficult to control, the shooting position and the target area are difficult to align, the shooting object is complex to align, and the like, so that the analysis accuracy and the user experience degree are directly influenced.
Disclosure of Invention
In view of the above, the invention provides a chip for rapidly extracting and crystallizing saliva, which is fast and convenient to implement, and does not need to integrate the functions of collecting, filtering and extracting the saliva into crystals through too many manual operations. Effectively improving the speed and the reliability of the saliva ovulation detection method.
A micro-fluidic chip for quickly extracting and crystallizing saliva comprises a chip main body and a sampling pool cover.
The chip main part include sampling cell 2, imbibition membrane 1, the stock solution pond 3 of storage buffer solution, with sampling cell lid complex spout 5, microfluid passageway 7, crystallizer 8 and air vent 9. The vent hole 9 is positioned at one end of the crystallization tank 8, and the microfluidic channel 7 is communicated with the sampling tank 2 and the crystallization tank 8. Meanwhile, the liquid absorption film 1 divides the sampling pool 2 into a sampling pool upper part 21 and a sampling pool 22, and the liquid storage pool 3 is positioned in the inner wall of one side of the sampling pool upper part 21 and is separated from the sampling pool 2 through a film 4. The chute 5 is positioned on one side opposite to the liquid storage tank 3 and is communicated with the sampling tank 2 and the edge of the chip, and the two sides of the chute 5 are provided with limiting chutes 6 matched with the sampling tank cover.
One end of the sampling pool cover is provided with a needle-shaped structure 10, and the two sides of the sampling pool cover are provided with limiting columns 11 matched with the limiting sliding grooves 6.
The liquid absorption film 1 is a porous liquid absorption material which accords with the medical detection standard, and the size of the liquid absorption film is determined by the detection volume requirement of a sample injection product. The liquid absorbing film 1 can absorb and replace saliva and filter most of air bubbles and solid residues.
The film 4 for separating the liquid storage tank 3 and the sampling tank 2 can be made of organic polymer film materials or other inert film materials.
The sampling pool cover is inserted into the side without the needle-shaped structure 10 at the unused stage of the chip, covers and seals the sampling pool 2, and protects the liquid absorption film 1 and the film 4 from being polluted and damaged; in the using stage of the chip, the side provided with the needle-like structure 10 is inserted, and the needle-like structure 10 breaks the thin film 4 to release the buffer solution while covering and sealing the sampling pool 2.
The shape of the crystallization tank 8 is not limited to rectangle and circle. The diameter or diagonal length of the cable is 4 mm-7 mm.
The invention provides a micro-fluidic chip for quickly extracting crystals from saliva, which has the advantage that the chip integrates the processes of collecting, filtering and extracting the saliva through the combination of a liquid absorption film and a buffer solution. The absorption efficiency of the liquid absorption film and the unique sampling form improve the collection efficiency of saliva and break the psychological barrier of a user. The liquid absorption film absorbs saliva and filters most of air bubbles and solid residues on the upper part of the sampling pool, so that a relatively pure saliva sample is obtained. And a closed system is adopted, so that saliva is prevented from being damaged by external impurities in the crystallization process, and the detection result is influenced. Because of the imbibition membrane is under fixed size, can once only absorb the saliva volume of fixed quantity, can be according to the influence of crystallization chamber size and different saliva thickness to the crystallization effect, the saliva volume of ration absorption reaches best crystallization effect. And the smaller crystallization tank can realize the global observation of saliva under a microscopic visual angle, so that the detection accuracy is improved.
Description of the drawings:
in order to more clearly illustrate the technical solution of the present invention, the drawings used in the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art that other drawings can be obtained from the drawings without inventive labor.
FIG. 1 is a schematic diagram of a microfluidic chip according to the present invention
FIG. 2 is a top view of a chip main body of the microfluidic chip according to the present invention
FIG. 3 is a schematic diagram of the upper part and the sliding groove part of the sampling pool of the microfluidic chip of the invention
FIG. 4 is a schematic diagram of the upper part and the sliding groove part of the sampling pool of the microfluidic chip in an unused state
FIG. 5 is a schematic diagram of the upper part and the sliding groove part of the sampling pool of the microfluidic chip in a use state
The specific implementation method comprises the following steps:
the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The invention discloses a chip for quickly extracting saliva and crystallizing, which is composed of a chip main body and a sampling pool cover, and is combined with attached drawings 1-5.
The chip main body consists of a sampling pool 2, a liquid absorption film 1, a liquid storage pool 3 for storing buffer liquid, a sliding groove 5 matched with a sampling pool cover, a microfluid channel 7, a crystallization pool 8 and a vent hole 9; air vent 9 is located 8 one ends of crystallizer and from chip end opening, microfluid passageway 7 intercommunication sampling pool 2 and crystallizer 8, it is partial 22 down with sampling pool 2 to divide into sampling pool upper part 21 with sampling pool simultaneously to inhale liquid membrane 1, liquid reserve tank 3 is located 21 left side inner walls on the sampling pool and separates with sampling pool 2 through film 4, spout 5 is located 3 relative one sides of liquid reserve tank, intercommunication sampling pool 2 and chip edge, 5 both sides of spout are equipped with and sample the spacing spout 6 of pond lid complex.
One end of the sampling pool cover is provided with a needle-shaped structure 10, and the two sides of the sampling pool cover are provided with limiting columns 11 matched with the limiting sliding grooves 6.
The liquid absorption film 1 is a porous liquid absorption material which accords with the medical detection standard, and the size of the liquid absorption film is determined by the detection volume requirement of a sample injection product. The liquid absorbing film 1 can absorb and replace saliva and filter most of air bubbles and solid residues.
The film 4 for separating the liquid storage tank 3 and the sampling tank 2 can be made of organic polymer film materials or other inert film materials.
The sampling pool cover is inserted into the side without the needle-shaped structure 10 as shown in figure 4 at the unused stage of the chip, and covers and seals the sampling pool 2 to protect the liquid absorption film 1 and the film 4 from being polluted and damaged; in the using stage of the chip, as shown in FIG. 5, the side of the sampling cell cover provided with the needle-like structure 10 is inserted, and the needle-like structure 10 breaks the thin film 4 to release the buffer solution while covering and sealing the sampling cell 2.
The shape of the crystallization tank 8 is not limited to rectangle and circle. The diameter or diagonal length of the cable is 4 mm-10 mm.
When the user uses, will cover the sampling pond lid roll-off of sampling pond 2, with chip main part imbibition membrane 1 one end, contain in the entry, make imbibition membrane 1 upside and saliva fully contact, absorb, take out after imbibition membrane 1 is full. Then, as shown in FIG. 5, one side of the needle-like structure 10 of the sampling pool cover is inserted into the chute 5 until the needle-like structure 10 breaks the film 4, and covers and seals the sampling pool 2. After the thin film 4 is broken, the buffer solution is released to flow into the sampling pool 2 to contact with the upper side of the imbibing film 1, the saliva is displaced from the imbibing film 1 to the sampling pool lower part 22, and then the saliva flows into the crystallization pool 8 through the microfluidic channel 7 to be dried and crystallized.
The invention provides a micro-fluidic chip for quickly extracting crystals from saliva, which has the advantage that the chip integrates the processes of collecting, filtering and extracting the saliva through the combination of a liquid absorption film and a buffer solution. The absorption efficiency of the liquid absorption film and the unique sampling form improve the collection efficiency of saliva and break through the psychological barrier of users in public places. The liquid absorption film absorbs saliva and filters most of air bubbles and solid residues on the upper part of the sampling pool, so that a relatively pure saliva sample is obtained. And a closed system is adopted, so that saliva is prevented from being damaged by external impurities in the crystallization process, and the detection result is influenced. Because of the imbibition membrane is under fixed size, can once only absorb the saliva volume of fixed quantity, can be according to the influence of crystallization chamber size and different saliva thickness to the crystallization effect, the ration absorbs the saliva volume, reaches best crystallization effect. The fixed position of the crystallization pool can solve the problems that the alignment of the shooting position and the target area is difficult, the alignment operation of the shooting object is complex and the like, and the small size of the crystallization pool can realize the global observation of saliva under a microscopic viewing angle, so that the detection accuracy is improved.
Claims (5)
1. A micro-fluidic chip for rapid extraction and crystallization of saliva is characterized in that the chip consists of a chip main body and a sampling pool cover;
the chip main body consists of a sampling pool 2, a liquid absorption film 1, a liquid storage pool 3 for storing buffer liquid, a sliding groove 5 matched with a sampling pool cover, a microfluid channel 7, a crystallization pool 8 and a vent hole 9; the vent hole 9 is positioned at one end of the crystallization tank 8, and the microfluidic channel 7 is communicated with the sampling tank 2 and the crystallization tank 8; meanwhile, the liquid absorption film 1 divides the sampling pool 2 into an upper sampling pool part 21 and a lower sampling pool part 22, and the liquid storage pool 3 is positioned in the inner wall of one side of the upper sampling pool part 21 and is separated from the sampling pool 2 through a film 4; spout 5 is located the relative one side of liquid storage tank 3, communicates sampling pool 2 and chip edge, 5 both sides of spout be equipped with sampling pool lid complex spacing spout 6, sampling pool lid one end is equipped with needle structure 10, its both sides be equipped with spacing post 11 of 6 matched with of spacing spout.
2. The microfluidic chip for rapid extraction and crystallization of saliva according to claim 1, wherein the liquid absorption membrane 1 is a porous liquid absorption material meeting medical detection standards, and the size of the porous liquid absorption material is determined by the volume requirement of sample detection; the liquid-absorbent film 1 absorbs and displaces saliva and at the same time filters most of the air bubbles and solid residues.
3. The microfluidic chip for rapid extraction and crystallization of saliva according to claim 1, wherein the membrane 4 separating the reservoir 3 from the sampling reservoir 2 is made of organic polymer membrane material or other inert membrane material.
4. The microfluidic chip for rapid extraction and crystallization of saliva according to claim 1, wherein the sampling cell cover is inserted into the side without the needle-like structure 10 at the stage of non-use of the chip, and covers and seals the sampling cell 2 to protect the liquid absorption membrane 1 and the thin membrane 4 from contamination and damage; in the using stage of the chip, the side provided with the needle-like structure 10 is inserted, and the needle-like structure 10 breaks the thin film 4 to release the buffer solution while covering and sealing the sampling pool 2.
5. The microfluidic chip for rapid extraction and crystallization of saliva according to claim 1, wherein the shape of the crystallization pool 8 is not limited to rectangle or circle, and the diameter or diagonal length thereof is 4 mm-10 mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011084434.6A CN112295620A (en) | 2020-10-12 | 2020-10-12 | Saliva draws crystallization micro-fluidic chip fast |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011084434.6A CN112295620A (en) | 2020-10-12 | 2020-10-12 | Saliva draws crystallization micro-fluidic chip fast |
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| Publication Number | Publication Date |
|---|---|
| CN112295620A true CN112295620A (en) | 2021-02-02 |
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|---|---|---|---|
| CN202011084434.6A Pending CN112295620A (en) | 2020-10-12 | 2020-10-12 | Saliva draws crystallization micro-fluidic chip fast |
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