CN112294906B - Composition for regulating spleen and stomach, promoting digestion and relaxing bowels for children and preparation method thereof - Google Patents
Composition for regulating spleen and stomach, promoting digestion and relaxing bowels for children and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
- A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
The invention belongs to the technical field of regulating spleen and stomach, helping digestion and relaxing bowels, and particularly relates to a composition for regulating spleen and stomach, helping digestion and relaxing bowels for children and a preparation method thereof; the composition comprises 250 parts of tuckahoe, 200 parts of Chinese date, 30 parts of yam, 20 parts of endothelium corneum gigeriae galli, 400 parts of hawthorn, 60 parts of polymerized sugar and 120 parts of xylitol; the hawthorn and the chicken's gizzard-membrane are combined to remove blood stasis and promote qi circulation, promote the peristalsis of the gastrointestinal tract, promote the discharge of contents and accelerate the discharge of harmful toxin and harmful bacteria; so as to achieve the effect of 'Tong'; xylo-oligosaccharide can activate beneficial bacteria such as lactobacillus and Bacillus bifidus, etc., to produce a large amount of short chain fatty acids; can stimulate intestinal peristalsis, increase stool wetness, and maintain certain osmotic pressure, thereby preventing constipation; the tuckahoe and the Chinese date are used together, and have the effect of nourishing vital energy on vital energy of heart, liver, spleen, lung and kidney; "healthy qi" is a resistance against the invasion of disease.
Description
Technical Field
The invention belongs to the technical field of spleen and stomach regulation, digestion assistance and constipation relief, and particularly relates to a composition for regulating the spleen and stomach, promoting digestion and relaxing the bowels for children and a preparation method thereof.
Background
Food retention in children: food retention is a disease of traditional Chinese medicine, and mainly refers to gastrointestinal diseases caused by excessive milk food in children, damage to spleen and stomach and stagnation of milk food in middle-jiao. Food retention syndrome usually occurs in infants, and is mainly manifested by abdominal fullness, dry stool or acid odor, bad odor, belching with acid, and abdominal distention and fever. After long-term eating, malnutrition of the children can be caused, and growth and development are affected.
Constipation of children: according to epidemiological investigation, the incidence rate of constipation of children in China is 3.8%, the incidence rate of constipation in cities and towns is 4.65%, the incidence rate of constipation in rural areas is 2.38%, the incidence rate of constipation in boys is 2.73%, and the incidence rate of constipation in girls is 4.07%. Wherein 90-95% of the constipation symptoms are functional constipation. Experts point out that functional constipation of children is one of the functional gastrointestinal diseases of children which are mainly prevented and treated at present. Scientists find that children who frequently suffer constipation in young children not only have poor memory, but also have great influence on thinking ability. Feces are accumulated in intestinal tracts for a long time and are fermented again to generate a large amount of toxic substances, and if the toxic substances cannot be discharged out of the body in time, the toxic substances may have adverse effects on the nervous system of people.
Chinese patent discloses a composition for removing food retention and relaxing bowels, preventing gastrointestinal cold and enhancing immunity for children, and the patent application number is 2016103387157, the composition comprises 250 parts of poria cocos, 200 parts of Chinese date, 30 parts of Chinese yam, 20 parts of endothelium corneum gigeriae galli, 400 parts of hawthorn and 60 parts of polymerized sugar by weight; the composition can be prepared into tablet, capsule, powder, pill, granule, paste, oral liquid, sustained release preparation, and quick release preparation by extracting, concentrating, refining, and adding adjuvants.
The composition has the effects of resolving food stagnation, relaxing bowels and treating gastrointestinal cold; when the traditional combination is prepared in a combined way, most of the raw materials of the combination are mixed with each other and then prepared into granules, capsules or oral liquid; the composition is different in drug property and taste, most of the compositions are sweet and bitter, so that the composition is difficult to be eaten by children, and the phenomenon that the children are difficult to take or have anorexia is easily caused, so that the effects of the composition on efficiently regulating spleen and stomach and promoting digestion of the children are influenced.
Disclosure of Invention
In order to make up the defects of the prior art, the invention provides a composition for regulating spleen and stomach, promoting digestion and relaxing bowels for children and a preparation method thereof, and the composition is mainly used for solving the problems that most raw materials of the composition are mixed with each other and then prepared into granules, capsules or oral liquid when the existing composition is prepared in a combined manner; the composition is different in drug property and taste, most of the compositions are sweet and bitter, so that the composition is difficult to be eaten by children, and the phenomenon that the children are difficult to take or have anorexia is easily caused, so that the effects of the composition on efficiently regulating spleen and stomach and promoting digestion of the children are influenced.
The technical scheme adopted by the invention for solving the technical problems is as follows: the composition for regulating spleen and stomach, promoting digestion and relaxing bowels for children comprises, by weight, 250 parts of poria cocos, 200 parts of Chinese dates, 30 parts of Chinese yams, 20 parts of endothelium corneum gigeriae galli, 400 parts of hawthorn, 60 parts of polymerized sugar and 120 parts of xylitol;
hawthorn fruit: the hawthorn is sour and warm in taste, enables qi and blood to flow together, removes blood stasis without damaging new blood, moves stagnant qi without damaging healthy qi, and is applied to meat food stagnation; endothelium corneum Gigeriae Galli can remove food stagnation; gastrointestinal tract stagnation, and long retention time of gastrointestinal tract contents can cause the gastrointestinal tract to be in an unhealthy state and the quantity of harmful bacteria is large; the hawthorn and the chicken's gizzard-membrane are combined to remove blood stasis and promote qi circulation, promote the peristalsis of the gastrointestinal tract, promote the discharge of contents and accelerate the discharge of harmful toxin and harmful bacteria; so as to achieve the effect of 'Tong';
polymerized saccharide: the polymeric carbohydrate is not degraded by digestive enzymes in the intestinal tract, and can carry attached pathogenic bacteria to be discharged out of the body through the intestinal tract, so that the disease is prevented from colonizing in the intestinal tract, and the purpose of preventing diarrhea is achieved. Beneficial bacteria such as lactobacillus and bifidobacterium can be activated by polymerized saccharides to generate a large amount of short-chain fatty acid; can stimulate intestinal peristalsis, increase stool wetness, and maintain certain osmotic pressure, thereby preventing constipation;
chinese yam is sweet in taste and neutral in nature; it enters spleen, lung and kidney meridians. Tonifying spleen and nourishing stomach, promoting fluid production and benefiting lung; poria cocos, being sweet in nature, bland in flavor and neutral in flavor, enters heart, lung and spleen meridians; excrete dampness and induce diuresis, invigorate spleen and stomach. The two are used together, and have the efficacy of nourishing vital qi for the vital qi of heart, liver, spleen, lung and kidney; "healthy qi" is a resistance against the invasion of disease;
xylitol is a sweet substance with nutritive value and is also a normal intermediate of carbohydrate metabolism of human bodies;
the preparation method of the composition for regulating spleen and stomach, promoting digestion and relaxing bowels for children is suitable for preparing the composition; the method comprises the following steps:
s1: cleaning, drying and crushing the poria cocos, the Chinese dates, the Chinese yam, the endothelium corneum gigeriae galli and the hawthorn fruits which are collected according to the weight of each component of the composition, then adding 8 times of water, extracting for 2 times for 1.5h each time, concentrating, drying under reduced pressure, and crushing into mixed powder A; the raw materials can be prepared into dry solid medicines and can be prepared into powder after being processed; thereby improving the mixing uniformity of various medicines and improving the treatment effect of the medicines;
s2: putting the extracted polymeric saccharides and xylitol into an emulsifying pot, and heating and decocting to form emulsified syrup B; the polymeric saccharide and the xylitol are processed in a solution slurry mode, so that the nutrient components of the polymeric saccharide can be efficiently reserved;
s3: adding the mixed powder A prepared in the step S1 into an emulsifying pot, then adding a certain amount of water into the emulsifying pot, and then mixing, stirring and diluting the internal mixed powder A and the emulsifying syrup B in the emulsifying pot, thereby preparing the composition into oral liquid;
s4: injecting the emulsified syrup B prepared in the step S2 into a cavity of a capsule mold, and cooling the emulsified syrup B to form a capsule shell in the cavity; then injecting the mixed powder A prepared in the step S1 into a capsule shell, sealing the capsule shell, and preparing the composition into a capsule; the emulsified syrup B is taken as a capsule shell, the emulsified syrup B contains polymerized saccharide and xylitol, and the polymerized saccharide and the xylitol are sweet foods, so that the edible mouth feeling of children on capsules prepared from the composition is improved; meanwhile, the capsule shell which takes the polymerized saccharide and the xylitol as main raw materials ensures that when the capsule enters the digestive tract of children, the polymerized saccharide can be activated by the polymerized saccharide with beneficial bacteria such as lactobacillus, bifidobacterium and the like firstly to generate a large amount of short-chain fatty acid; can stimulate the intestinal peristalsis and increase the wetting degree of the excrement;
the capsule mould comprises an upper mould, a lower mould and a guide post; the upper surface of the upper die and the lower surface of the lower die are both provided with a plurality of arc-shaped cavities, and the arc-shaped cavities are aligned up and down; the upper surface of the lower die is provided with a plurality of guide grooves; a plurality of guide posts are fixed on the lower surface of the lower die and are respectively inserted into the guide grooves in a sliding manner; the arc-shaped cavities aligned up and down are jointed and sealed to form a cavity; the capsule film is provided with a plurality of capsule forming devices, and the capsule forming devices are used for preparing capsules; when the capsule preparation machine works, when a capsule mold is needed to be used for preparing capsules, an operator firstly cleans the upper mold, the lower mold and the capsule forming device, then the lower surface of the upper mold is attached to the upper surface of the upper mold, and the guide columns can position the upper mold and the lower mold; and then injecting the emulsified syrup B into the cavity through a capsule forming device to form a capsule shell, and then injecting the mixed powder A into the capsule shell, so that a plurality of capsules can be synchronously prepared, wherein the prepared capsules are suitable for children to eat safely.
Preferably, the capsule forming device comprises a grouting pipe, a powder guide pipe, an air guide pipe, an expansion balloon, an air guide main pipe, a liquid guide main pipe and a powder guide main pipe; the plurality of grouting pipes are fixed on the lower die, and inner pipe ports of the plurality of grouting pipes are respectively communicated with one ends of the plurality of arc-shaped cavities; the powder guide pipes are all fixed on the lower die, and inner pipe ports of the powder guide pipes are respectively communicated with the other ends of the arc-shaped cavities; the powder guide pipes are connected with air guide pipes through fixed sleeves, and the inner ports of the air guide pipes are used for fixing the air port ends of the expansion balloons; the outer diameter of the gas guide pipe is smaller than the inner diameter of the powder guide pipe; the inflatable balloon is collapsible within the airway tube; the outer pipe openings of the air guide pipes are communicated with an air guide main pipe, and one end part of the air guide main pipe is connected with an air supply pipe of an external air supply pump; the outer pipe openings of the plurality of grouting pipes are communicated with the main liquid guiding pipe, and the outer end part of the main liquid guiding pipe is communicated with a storage tank for storing the emulsified syrup B; the bottom ends of the powder guide pipes are communicated to the upper part of the powder guide main pipe through the shunt pipes, and the outer end part of the powder guide main pipe is communicated with a storage tank in which a mixed powder A is stored; when the device works, when the emulsified syrup B needs to be injected into the cavity to form a capsule shell, an operator controls the air supply pump box air guide main pipe to be filled with high-pressure air through the controller, the high-pressure air in the air guide main pipe can be uniformly distributed into the air guide pipes, the filled high-pressure air in the air guide pipes can blow air to the fixed expansion balloon at the inner port of each air guide pipe, so that a plurality of expansion balloons can form a capsule shell model in the plurality of cavities after being expanded, then the operator controls the storage tank of the emulsified syrup B to fill the emulsified syrup B into the air guide main pipe through the controller, the emulsified syrup B in the liquid guide main pipe can be respectively injected into the cavity through the plurality of grouting pipes, meanwhile, the emulsified syrup B injected into the cavity can form the capsule shell on the outer wall of the expanded expansion balloons, and when the emulsified syrup B is completely cooled to form the capsule shell, the controller controls the air supply pump to draw out the expanded balloons so that the expanded balloons can be contracted into the air guide pipes, then the controller controls the storage tank for storing the mixed powder A to fill the mixed powder A into the powder guide main pipe, the powder guide main pipe uniformly distributes the mixed powder A in the powder guide pipes into the powder guide pipes, and the mixed powder A is injected into the capsule shell through the powder guide pipes, so that the powder medicine with the functions of strengthening spleen and helping digestion is conveniently fed into the digestive tract of children by wrapping the capsule shell for preventing diarrhea, the high-efficiency treatment effect of the composition on the children is improved, and meanwhile, the phenomenon that the medicine effect of the composition is excessively lost is prevented; after the capsules are manufactured, an operator beats the upper die through the clamping device, so that a plurality of manufactured capsules can be conveniently taken out and stored, the rapid and efficient preparation of the capsules by the capsule forming device is improved, the emulsifying saccharification B and the mixed powder A can be conveniently formed and prepared in the capsule die at the same time, and the forming effect of the composition for preparing the capsules is further improved.
Preferably, the outer ends of the air guide pipes penetrate through the side wall of the air guide main pipe in a rotating and sealing manner, and gears are fixed at the outer ends of the air guide pipes; the outer ring wall of the air guide pipe positioned in the air guide main pipe is provided with a plurality of air guide through grooves, and the air guide through grooves are communicated with the air guide main pipe; the plurality of air guide pipes are in rotary sealing connection with the plurality of fixing sleeves; the bottom ends of the gears are meshed with racks, and one end parts of the racks are connected with telescopic ends of the electric telescopic rods; the electric telescopic rod is fixed on the wall provided with the capsule mould; when the device works, when the emulsified syrup B is filled between the outer wall of the expanded balloon and the wall of the cavity, the controller can control the electric telescopic rod to reciprocate, the electric telescopic rod stretches out to drive the rack to slide along the left and right horizontal directions of the outer wall of the air guide main pipe, the rack can drive the plurality of meshed gears to rotate by reciprocating movement, and the plurality of gears fix the end parts of the air guide pipes, the rotation of the air ducts can drive the expansion balloons to rotate in the cavity, the rotation of the expansion balloons can evenly coat the emulsion syrup B filled in the cavity on the outer wall of the expansion balloons, the thickness of the cavity wall of the formed capsule shell can be consistent, the safe storage of the mixed powder A by the capsule shell is improved, the phenomenon that the mixed powder A leaks in the capsule shell is prevented, and the phenomenon that the drug effect of the composition is lost is further prevented; meanwhile, after the emulsified syrup B is formed on the outer wall of the expanded expansion balloon, the air supply pump can inject cooling gas into the air guide pipe, so that the emulsified syrup B can be quickly and stably formed in the expansion balloon and the cavity; after the capsule shell is completely molded in the cavity, the controller can control the electric telescopic rod to slowly extend out, so that the expansion balloon can rotate in the cavity, and further the expansion balloon can be quickly separated from the cooled and solidified capsule shell to be bonded, and the expansion balloon can be conveniently and quickly contracted into the air duct; meanwhile, when the expansion balloon is bonded with the capsule shell, the capsule shell is prevented from being damaged due to rapid air suction and contraction of the expansion balloon, and the safe preparation of the capsule shell is further influenced.
Preferably, one end of the capsule shell is convex, and the other end of the capsule shell is sealed by a glutinous rice paper layer; during operation, scribble sealed sticky rice paper layer at the other end of capsule shell, because sticky rice paper layer's main raw materials is starch, and then when the capsule shell entered into the alimentary canal, the amylase in the alimentary canal can decompose sticky rice paper, can leak the alimentary canal with the inside mixed powder thing A who deposits of capsule shell after the sticky rice paper layer decomposes in, and then be convenient for mixed powder A can condition the effect of treatment to children's alimentary canal and spleen and stomach.
Preferably, the outer wall of the air duct is provided with a spiral groove, and a plurality of elastic bulges are fixed on the outer wall of the air duct; the elastic bulges are all positioned in the powder guide pipe; the during operation, when pouring into mixed powder thing A in the powder pipe, controller control electric telescopic handle stretches out this moment, make the air duct can be at the powder pipe internal rotation, and then mixed powder thing A that pours into in the powder pipe can be inside the capsule shell is stably carried through the helicla flute under the rotation of air duct, the rotation of air duct can drive a plurality of elastic bulge at the powder pipe internal rotation simultaneously, a plurality of elastic bulge can extrude crushing operation with the large granule mixed powder thing A that the powder pipe fills, not only prevent mixed powder thing A blocking phenomenon in the powder pipe, improve powder mixture A simultaneously and smash the utilization effect, improve alimentary canal and spleen stomach and to the quick absorption effect of medicine.
The invention has the following beneficial effects:
1. the hawthorn and the chicken's gizzard-membrane are combined, so that the blood stasis and qi circulation are removed, the peristalsis of the gastrointestinal tract is promoted, the discharge of contents is promoted, and the discharge of harmful toxin and harmful bacteria is accelerated; so as to achieve the effect of 'Tong'; the jujube and the tuckahoe are used together, and have the effect of nourishing vital qi for the vital qi of heart, liver, spleen, lung and kidney; "healthy qi" is a resistance against the invasion of disease.
2. According to the invention, the emulsified syrup B is a capsule shell, the emulsified syrup B contains polymerized saccharides which are sweet foods, so that the edible mouth feeling of children on capsules prepared from the composition is improved; meanwhile, the capsule shell which takes the polymerized saccharide as the main raw material ensures that when the capsule enters the digestive tract of children, the polymerized saccharide can be activated by the polymerized saccharide together with beneficial bacteria such as lactobacillus, bifidobacterium and the like to generate a large amount of short-chain fatty acid; can stimulate intestinal peristalsis and increase the wetting degree of excrement.
3. According to the invention, through the matching of the capsule mold and the capsule forming device, the forming quality of the capsule shell prepared in the step S4 can be improved, the rejection rate of the capsule shell preparation is reduced, the increased rework rate caused by the rejection of the capsule shell is avoided, the preparation procedures of the composition for regulating the spleen and stomach and promoting digestion and relaxing the bowels for children are reduced, and the waste generated by the preparation method of the composition during the capsule preparation is further reduced; meanwhile, the capsule forming device can independently fill the mixed powder A obtained in the step S1 into the capsule shell prepared in the step S4, so that the mixing uniformity of various medicines in the composition is further ensured, the preparation efficiency of the composition for regulating the spleen and stomach, promoting digestion and relaxing the bowels for children is improved, and the treatment effect of the composition is improved.
Drawings
The invention will be further explained with reference to the drawings.
FIG. 1 is a flow chart of a method of making a composition of the present invention;
FIG. 2 is a perspective view of the capsule mold of the present invention;
FIG. 3 is an assembly view of the upper and lower dies of the invention;
FIG. 4 is a cross-sectional view of the capsule mold of the present invention;
figure 5 is a view of the inflated balloon of the present invention in a deflated state;
FIG. 6 is a cross-sectional view of the powder conduit of the present invention;
FIG. 7 is a block diagram of the capsule shell of the present invention;
in the figure: the capsule forming device comprises a capsule mould 1, a cavity 11, an upper mould 2, a lower mould 3, a guide groove 31, an arc-shaped cavity 32, a guide column 4, a capsule shell 5, a capsule forming device 6, a grouting pipe 61, a powder guide pipe 62, an air guide pipe 63, an air guide through groove 631, a spiral groove 632, an elastic bulge 633, an expansion balloon 64, an air guide main pipe 65, a liquid guide main pipe 66, a powder guide main pipe 67, a fixed sleeve 68, a gear 7, a rack 8 and an electric telescopic rod 9.
Detailed Description
A composition for regulating the spleen and stomach, promoting digestion and relaxing bowels for children and a method for preparing the same according to an embodiment of the present invention will be described below with reference to fig. 1 to 7.
As shown in fig. 1-7, the composition for regulating spleen and stomach, promoting digestion and relaxing bowels for children comprises, by weight, 250 parts of poria cocos, 200 parts of Chinese date, 30 parts of Chinese yam, 20 parts of endothelium corneum gigeriae galli, 400 parts of hawthorn, 60 parts of polymerized sugar and 120 parts of xylitol;
hawthorn fruit: the hawthorn is sour and warm in taste, enables qi and blood to flow together, removes blood stasis without damaging new blood, moves stagnant qi without damaging healthy qi, and is applied to meat food stagnation; endothelium corneum Gigeriae Galli can remove food stagnation; gastrointestinal tract stagnation, and long retention time of gastrointestinal tract contents can cause the gastrointestinal tract to be in an unhealthy state and the quantity of harmful bacteria is large; the hawthorn and the chicken's gizzard-membrane are combined to remove blood stasis and promote qi circulation, promote the peristalsis of the gastrointestinal tract, promote the discharge of contents and accelerate the discharge of harmful toxin and harmful bacteria; so as to achieve the effect of 'Tong';
polymerized saccharide: the polymerized saccharide has the function of not being degraded by digestive enzymes in the intestinal tract, and can carry attached pathogenic bacteria to be discharged out of the body through the intestinal tract, thereby preventing diseases from colonizing in the intestinal tract and achieving the purpose of preventing diarrhea; beneficial bacteria such as lactobacillus and bifidobacterium can be activated by polymerized saccharides to generate a large amount of short-chain fatty acid; can stimulate intestinal peristalsis, increase stool wetness, and maintain certain osmotic pressure, thereby preventing constipation;
chinese yam is sweet in taste and neutral in nature; it enters spleen, lung and kidney meridians. Tonifying spleen and nourishing stomach, promoting fluid production and benefiting lung; poria cocos, being sweet in nature, bland in flavor and neutral in flavor, enters heart, lung and spleen meridians; excrete dampness and induce diuresis, invigorate spleen and stomach. The two are used together, and have the efficacy of nourishing vital qi for the vital qi of heart, liver, spleen, lung and kidney; "healthy qi" is a resistance against the invasion of disease;
xylitol is a sweet substance with nutritive value and is also a normal intermediate of carbohydrate metabolism of human bodies;
the preparation method of the composition for regulating spleen and stomach, promoting digestion and relaxing bowels for children is suitable for preparing the composition; the method comprises the following steps:
s1: cleaning, drying and crushing the poria cocos, the Chinese dates, the Chinese yam, the endothelium corneum gigeriae galli and the hawthorn fruits which are collected according to the weight of each component of the composition, then adding 8 times of water, extracting for 2 times for 1.5h each time, concentrating, drying under reduced pressure, and crushing into mixed powder A; the raw materials can be prepared into dry solid medicines and can be prepared into powder after being processed; thereby improving the mixing uniformity of various medicines and improving the treatment effect of the medicines;
s2: putting the extracted polymeric saccharides and xylitol into an emulsifying pot, and heating and decocting to form emulsified syrup B; the polymeric saccharide and the xylitol are processed in a solution slurry mode, so that the nutrient components of the polymeric saccharide can be efficiently reserved;
s3: adding the mixed powder A prepared in the step S1 into an emulsifying pot, then adding a certain amount of water into the emulsifying pot, and then mixing, stirring and diluting the internal mixed powder A and the emulsifying syrup B in the emulsifying pot, thereby preparing the composition into oral liquid;
s4: injecting the emulsified syrup B prepared in the step S2 into a cavity 11 of a capsule mold 1, so that a capsule shell 5 can be formed in the cavity 11 after the emulsified syrup B is cooled; then injecting the mixed powder A prepared in the step S1 into a capsule shell 5, sealing the capsule shell 5, and preparing the composition into a capsule; the emulsified syrup B is taken as a capsule shell 5, the emulsified syrup B contains polymerized sugar and xylitol, and the polymerized sugar and the xylitol are sweet foods, so that the edible mouth feeling of children on capsules prepared from the composition is improved; meanwhile, the capsule shell 5 which takes the polymerized saccharide and the xylitol as main raw materials ensures that when the capsule enters the digestive tract of children, the polymerized saccharide can be activated by the polymerized saccharide with beneficial bacteria such as lactobacillus, bifidobacterium and the like firstly to generate a large amount of short-chain fatty acid; can stimulate the intestinal peristalsis and increase the wetting degree of the excrement;
the capsule mould 1 comprises an upper mould 2, a lower mould 3 and a guide post 4; the upper surface of the upper die 2 and the lower surface of the lower die 3 are both provided with a plurality of arc-shaped cavities 32, and the arc-shaped cavities 32 are aligned up and down; the upper surface of the lower die 3 is provided with a plurality of guide grooves 31; a plurality of guide posts 4 are fixed on the lower surface of the lower die 3, and the guide posts 4 are respectively inserted into the guide grooves 31 in a sliding manner; the arc-shaped cavity 32 aligned up and down is jointed and sealed to form a cavity 11; the capsule film is provided with a plurality of capsule forming devices 6, and the capsule forming devices 6 are used for preparing capsules; when the capsule preparation machine works, when a capsule mold 1 is needed to be used for preparing capsules, an operator firstly cleans the upper mold 2, the lower mold 3 and the capsule forming device 6, then the lower surface of the upper mold 2 is attached to the upper surface of the upper mold 2, and the guide columns 4 can position the upper mold 2 and the lower mold 3; then, the emulsified syrup B is firstly injected into the cavity 11 through the capsule forming device 6 to form a capsule shell 5, then the mixed powder A is injected into the capsule shell 5, and then a plurality of capsules can be synchronously prepared, wherein the prepared capsules are suitable for children to eat safely.
As an embodiment of the present invention, the capsule forming device 6 includes a grouting pipe 61, a powder conduit 62, an air duct 63, an expansion balloon 64, an air duct main pipe 65, a liquid guide main pipe 66, and a powder guide main pipe 67; a plurality of the grouting pipes 61 are all fixed on the lower die 3, and inner pipe ports of the plurality of grouting pipes 61 are respectively communicated with one ends of the plurality of arc-shaped cavities 32; a plurality of the powder conduits 62 are all fixed on the lower die 3, and the inner pipe ports of the plurality of powder conduits 62 are respectively communicated with the other ends of the plurality of arc-shaped cavities 32; the powder guide tubes 62 are connected with air guide tubes 63 through fixing sleeves 68, and the inner ports of the air guide tubes 63 are used for fixing the air port ends of the expansion balloons 64; the outer diameter of the air duct 63 is smaller than the inner diameter of the powder duct 62; the inflatable balloon 64 is retractable within the airway tube 63; the outer pipe openings of the plurality of air guide pipes 63 are communicated with an air guide main pipe 65, and one end part of the air guide main pipe 65 is connected with an air supply pipe of an external air supply pump; the outer pipe openings of the plurality of grouting pipes 61 are communicated with a main liquid guiding pipe 66, and the outer end part of the main liquid guiding pipe 66 is communicated with a storage tank for storing emulsified syrup B; the bottom ends of the powder guide pipes 62 are communicated with the upper part of the powder guide main pipe 67 through the shunt pipes, and the outer end part of the powder guide main pipe 67 is communicated with a storage tank for storing the mixed powder A; when the device works, when the emulsified syrup B needs to be injected into the cavity 11 to form the capsule shell 5, an operator controls the air supply pump box air guide main pipe 65 to be filled with high-pressure air through the controller, the high-pressure air in the air guide main pipe 65 can be uniformly distributed into the air guide pipes 63, the high-pressure air filled in the air guide pipes 63 can blow air to the expansion balloon 64 fixed at the inner port of each air guide pipe 63, so that the expansion balloons 64 can form a model of the capsule shell 5 in the cavity 11 after being expanded, then the operator controls the storage tank of the emulsified syrup B to be filled into the emulsified syrup B in the liquid guide main pipe 66 through the controller, the emulsified syrup B in the liquid guide main pipe 66 can be respectively injected into the cavity 11 through the plurality of grouting pipes 61, and the emulsified syrup B injected into the cavity 11 can form the capsule shell 5 on the outer wall of the expanded expansion balloon 64, after the emulsified syrup B is completely cooled to form the capsule shell 5, the controller controls the air supply pump to draw out the expanded expansion balloons 64, so that the expansion balloons 64 can be contracted into the air guide pipes 63, then the controller controls the storage tank for storing the mixed powder A to fill the mixed powder A into the powder guide main pipe 67, the powder guide main pipe 67 uniformly distributes the mixed powder A in the powder guide pipes 62, and the mixed powder A is injected into the capsule shell 5 through the powder guide pipes 62, so that the powdered medicine with the functions of tonifying spleen and helping digestion is conveniently sent into the digestive tract of children by wrapping the capsule shell 5 for preventing diarrhea, the high-efficiency treatment effect of the composition on the children is improved, and meanwhile, the phenomenon that the medicine effect of the composition is excessively lost is prevented; after the capsules are manufactured, an operator beats the upper die 2 through the clamping device, so that a plurality of manufactured capsules can be conveniently taken out and stored, the rapid and efficient preparation of the capsules by the capsule forming device 6 is improved, the emulsifying saccharification C and the mixed powder A can be conveniently formed and prepared in the capsule die 1, and the forming effect of the composition for preparing the capsules is further improved.
As an embodiment of the present invention, the outer ends of the plurality of air ducts 63 are all sealed to penetrate through the side wall of the main air duct 65, and the outer ends of the plurality of air ducts 63 are all fixed with gears 7; the outer ring wall of the air duct 63 inside the air duct main pipe 65 is provided with a plurality of air guide through grooves 631, and the air guide through grooves 631 are communicated with the air duct main pipe 65; the plurality of air guide tubes 63 are in rotary sealing connection with a plurality of fixing sleeves 68; the bottom ends of the gears 7 are meshed with racks 8, and one end of each rack 8 is connected with the telescopic end of an electric telescopic rod 9; the electric telescopic rod 9 is fixed on the wall provided with the capsule mould 1; when the device works, when the emulsified syrup B is filled between the outer wall of the expanded expansion balloon 64 and the wall of the cavity 11, the controller can control the electric telescopic rod 9 to reciprocate, the electric telescopic rod 9 extends out to drive the rack 8 to slide along the left and right horizontal directions of the outer wall of the air guide main pipe 65, the rack 8 can drive the plurality of meshed gears 7 to rotate in a reciprocating manner, the plurality of gears 7 fix the end parts of the air guide pipes 63, the plurality of expanded expansion balloons 64 can be driven to rotate in the cavity 11 by the rotation of the plurality of air guide pipes 63, the emulsified syrup B filled in the cavity 11 can be uniformly coated on the outer wall of the expansion balloons 64 by the rotation of the expansion balloons 64, the wall thickness of the formed capsule shell 5 can be consistent, the safe storage of the capsule shell 5 on the mixed powder A is improved, and the leakage phenomenon of the mixed powder A in the capsule shell 5 is prevented, thereby causing the phenomenon of loss of the efficacy of the composition; meanwhile, after the emulsified syrup B is formed on the outer wall of the expanded expansion balloon 64, the air supply pump can inject cooling gas into the air guide pipe 63, so that the emulsified syrup B can be quickly and stably formed in the expansion balloon 64 and the cavity 11; after the capsule shell 5 is completely molded in the cavity 11, the controller can control the electric telescopic rod 9 to slowly extend out, so that the expansion balloon 64 can rotate in the cavity 11, and further the expansion balloon 64 can be quickly separated from the cooled and solidified capsule shell 5 to be bonded, and the expansion balloon 64 can be conveniently and quickly contracted into the air duct 63; meanwhile, when the expansion balloon 64 is bonded with the capsule shell 5, the capsule shell 5 is prevented from being damaged due to rapid air suction and contraction of the expansion balloon 64, and the safe preparation of the capsule shell 5 is further influenced.
In one embodiment of the present invention, one end of the capsule shell 5 is convex, and the other end of the capsule shell 5 is sealed by a glutinous rice paper layer; during operation, scribble sealed sticky rice paper layer at capsule shell 5's the other end, because sticky rice paper layer's main raw materials is starch, and then when capsule shell 5 entered into the alimentary canal, amylase in the alimentary canal can decompose sticky rice paper, can leak the alimentary canal with the inside mixed powder thing A of depositing of capsule shell 5 after sticky rice paper layer decomposes in, and then be convenient for mixed powder A can condition the effect of treatment to children's alimentary canal and spleen and stomach.
As an embodiment of the present invention, the outer wall of the air duct 63 is provided with a spiral groove 632, and the outer wall of the air duct 63 is fixed with a plurality of elastic protrusions 633; a plurality of resilient protrusions 633 are located within the powder conduit 62; the during operation, when pouring into mixed powder thing A in powder pipe 62, controller control electric telescopic handle 9 stretches out this moment, make the air duct 63 can be at the internal rotation of powder pipe 62, and then the mixed powder thing A of pouring into in the powder pipe 62 can be stably carried inside capsule shell 5 through helicla flute 632 under the rotation of air duct 63, the rotation of air duct 63 can drive a plurality of elastic bulge 633 at the internal rotation of powder pipe 62 simultaneously, a plurality of elastic bulge 633 can extrude crushing operation with the large granule mixed powder thing A that powder pipe 62 fills, not only prevent mixed powder thing A blocking phenomenon in powder pipe 62, improve powder mixture A simultaneously and smash the utilization effect, improve the quick absorption effect of alimentary canal and spleen stomach to the medicine.
The specific working process is as follows:
when the device works, when the emulsified syrup B needs to be injected into the cavity 11 to form the capsule shell 5, an operator controls the air supply pump box air guide main pipe 65 to be filled with high-pressure air through the controller, the high-pressure air in the air guide main pipe 65 can be uniformly distributed into the air guide pipes 63, the high-pressure air filled in the air guide pipes 63 can blow air to the expansion balloon 64 fixed at the inner port of each air guide pipe 63, so that the expansion balloons 64 can form a model of the capsule shell 5 in the cavity 11 after being expanded, then the operator controls the storage tank of the emulsified syrup B to be filled into the emulsified syrup B in the liquid guide main pipe 66 through the controller, the emulsified syrup B in the liquid guide main pipe 66 can be respectively injected into the cavity 11 through the plurality of grouting pipes 61, and the emulsified syrup B injected into the cavity 11 can form the capsule shell 5 on the outer wall of the expanded expansion balloon 64, after the emulsified syrup B is cooled to completely form the capsule shell 5, the controller controls the air supply pump to draw out the expanded expansion balloons 64, so that the expansion balloons 64 can contract into the air guide pipes 63, then the controller controls the storage tank for storing the mixed powder A to fill the mixed powder A into the powder guide main pipe 67, the powder guide main pipe 67 uniformly distributes the mixed powder A into the powder guide pipes 62, the mixed powder A is injected into the capsule shell 5 through the powder guide pipes 62, and then the powdered medicine with the spleen tonifying and digestion promoting effect is conveniently sent into the digestive tract of the child through the package of the capsule shell 5 for preventing diarrhea, so that the high-efficiency treatment effect of the composition on the child is improved, and meanwhile, the phenomenon that the medicine effect of the composition is excessively lost is prevented.
In the description of the present invention, it is to be understood that the terms "center", "front", "rear", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc., indicate orientations or positional relationships based on those shown in the drawings, and are used only for convenience in describing the present invention and for simplicity in description, and do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore, should not be taken as limiting the scope of the present invention.
While the invention has been described with reference to specific embodiments, it will be understood by those skilled in the art that various changes may be made and equivalents may be substituted without departing from the scope of the invention. In addition, many modifications may be made to adapt a particular situation or material to the teachings of the invention without departing from its scope. Therefore, it is intended that the invention not be limited to the particular embodiment disclosed, but that the invention will include all embodiments falling within the scope of the appended claims.
Claims (2)
1. A preparation facilities of children's spleen and stomach, help digestion and relax bowels composition which characterized in that: the capsule mould comprises a capsule mould, wherein the capsule mould (1) comprises an upper mould (2), a lower mould (3) and a guide post (4); the upper surface of the upper die (2) and the lower surface of the lower die (3) are both provided with a plurality of arc-shaped cavities (32), and the arc-shaped cavities (32) are aligned up and down; the upper surface of the lower die (3) is provided with a plurality of guide grooves (31); a plurality of guide posts (4) are fixed on the lower surface of the lower die (3), and the guide posts (4) are respectively inserted into the guide grooves (31) in a sliding manner; the arc-shaped cavities (32) aligned up and down are attached and sealed to form a forming cavity (11); the capsule film is provided with a plurality of capsule forming devices (6), and the capsule forming devices (6) are used for preparing capsules;
the capsule forming device (6) comprises a grouting pipe (61), a powder guide pipe (62), an air guide pipe (63), an expansion balloon (64), an air guide main pipe (65), a liquid guide main pipe (66) and a powder guide main pipe (67); the plurality of grouting pipes (61) are all fixed on the lower die (3), and inner pipe orifices of the plurality of grouting pipes (61) are respectively communicated with one ends of the plurality of arc-shaped cavities (32); the powder conduits (62) are all fixed on the lower die (3), and the inner pipe ports of the powder conduits (62) are respectively communicated with the other ends of the arc-shaped cavities (32); the powder guide pipes (62) are internally connected with air guide pipes (63) through fixing sleeves (68), and the inner ports of the air guide pipes (63) are used for fixing the air port ends of the expansion balloons (64); the outer diameter of the air guide pipe (63) is smaller than the inner diameter of the powder guide pipe (62); the inflatable balloon (64) can be contracted in the air duct (63); the outer pipe openings of the air guide pipes (63) are communicated with an air guide main pipe (65), and one end part of the air guide main pipe (65) is connected with an air supply pipe of an external air supply pump; the outer pipe openings of the grouting pipes (61) are communicated with a main liquid guide pipe (66), and the outer end part of the main liquid guide pipe (66) is communicated with a storage tank for storing emulsified syrup B; the bottom ends of the powder guide pipes (62) are communicated to the upper part of the powder guide main pipe (67) through flow dividing pipes, and the outer end part of the powder guide main pipe (67) is communicated with a storage tank for storing a mixed powder A;
the outer ends of the air guide pipes (63) penetrate through the side wall of the air guide main pipe (65) in a rotating and sealing manner, and gears (7) are fixed at the outer ends of the air guide pipes (63); the outer ring wall of the air guide pipe (63) positioned in the air guide main pipe (65) is provided with a plurality of air guide through grooves (631), and the air guide through grooves (631) are communicated with the air guide main pipe (65); the plurality of air guide pipes (63) are connected with a plurality of fixing sleeves (68) in a rotating and sealing way; the bottom ends of the gears (7) are meshed with racks (8), and one end of each rack (8) is connected with the telescopic end of an electric telescopic rod (9); the electric telescopic rod (9) is fixed on a wall provided with the capsule mould (1);
the composition for regulating spleen and stomach, promoting digestion and relaxing bowels for children comprises, by weight, 250 parts of poria cocos, 200 parts of Chinese date, 30 parts of Chinese yam, 20 parts of endothelium corneum gigeriae galli, 400 parts of hawthorn, 60 parts of polymerized sugar and 120 parts of xylitol;
the preparation method of the mixed powder A comprises the following steps: cleaning, drying and crushing poria cocos, Chinese dates, Chinese yam, endothelium corneum gigeriae galli and hawthorn fruits which are collected according to the weight of each component of the composition for regulating spleen and stomach, promoting digestion and relaxing bowels for children, then adding 8 times of water, extracting for 2 times, extracting for 1.5h each time, concentrating, drying under reduced pressure, and crushing into mixed powder A;
the preparation method of the emulsified syrup B comprises the following steps: and putting the extracted polymeric saccharide and xylitol into an emulsifying pot for heating and decocting to form emulsified syrup B.
2. The preparation device of the composition for adjusting spleen and stomach, promoting digestion and relaxing bowels for children as claimed in claim 1, wherein: the outer wall of the air duct (63) is provided with a spiral groove (632), and a plurality of elastic bulges (633) are fixed on the outer wall of the air duct (63); a plurality of resilient protrusions (633) are each located within the powder conduit (62).
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| CN105662870A (en) * | 2016-02-25 | 2016-06-15 | 重庆衡生药用胶囊有限责任公司 | Re-dipping full-automatic forming manufacturing production line for enteric empty capsules |
| CN105796821A (en) * | 2016-05-20 | 2016-07-27 | 河北御芝林药业有限公司 | Composition for removing food retention and relaxing bowels, preventing gastrointestinal cold and boosting immunity in children |
| CN207404801U (en) * | 2017-10-25 | 2018-05-25 | 浙江益立胶囊股份有限公司 | A kind of capsule shell production mould rotates and upgrades device |
| CN208630888U (en) * | 2018-07-04 | 2019-03-22 | 湖北人福成田药业有限公司 | A kind of pharmaceutical production filling and sealing machine installing cooling device additional |
| CN209535958U (en) * | 2018-12-29 | 2019-10-25 | 绿健园（新乡）生物工程有限公司 | A kind of full-automatic encapsulating machine |
| CN111700803A (en) * | 2020-06-28 | 2020-09-25 | 张小平 | Medical western medicine capsule production system |
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Effective date of registration: 20211230 Address after: 050000 Haihe Road 168, hi tech Zone, Shijiazhuang, Hebei Applicant after: HEBEI YUZHILIN BIOTECHNOLOGY Co.,Ltd. Address before: No.638 Xinglin Road, Nanhe Industrial Park, Xingtai City, Hebei Province 054400 Applicant before: HEBEI YUZHILIN PHARMACEUTICAL Co.,Ltd. |