CN112245537A - 一种治疗肾病的组合物及其制备方法 - Google Patents
一种治疗肾病的组合物及其制备方法 Download PDFInfo
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- CN112245537A CN112245537A CN202011156751.4A CN202011156751A CN112245537A CN 112245537 A CN112245537 A CN 112245537A CN 202011156751 A CN202011156751 A CN 202011156751A CN 112245537 A CN112245537 A CN 112245537A
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Abstract
本发明公开了一种治疗肾病的组合物,包括以下重量份的原料:鸽肾冻干粉33‑40份、肉苁蓉8‑15份、黑豆8‑15份、黑米13‑20份、黑木耳18‑25份、松花粉3‑10份和莲子3‑10份;并且公开了其制备方法。本发明组合物可滋阴养血,改善肾脏环境,用于治疗肾病疗效显著。
Description
技术领域
本发明涉及中药技术领域,更具体的说是涉及一种治疗肾病的组合物及其制备方法。
背景技术
肾脏是人体的重要器官,其可清除体内代谢产物及有害物质,调节水、电解质平衡及维护酸碱平衡,保证机体内环境的稳定,使新陈代谢得以正常进行。
然而,日常生活中诸多习惯会影响肾脏健康,如长期食用高盐、高蛋白食物,喝水少,久坐,贪凉等等。
肾脏功能一旦出现损坏,人体有害物质的排泄便受到影响,废物在体内积聚,容易引起各种病症,如水肿、高血压、腰痛、贫血、痛风、尿化验异常、尿路感染等等。
通过西药对上述肾脏损伤症状进行治疗效果有限,并且由于化学药品的代谢排出也需要经过肾脏,容易增加肾脏负担,造成肾毒性。
因此,研究一种副作用小、且对肾脏损伤治疗效果好的组合物是本领域亟待解决的技术问题。
发明内容
有鉴于此,本发明提供了一种治疗肾病的组合物,使用天然药食同源成分进行配伍,副作用小,对于肾脏损伤疗效显著。
为了实现上述目的,本发明采用如下技术方案:
一种治疗肾病的组合物,包括以下重量份的原料:
鸽肾冻干粉33-40份、肉苁蓉8-15份、黑豆8-15份、黑米13-20份、黑木耳18-25份、松花粉3-10份和莲子3-10份。
鸽肾性平、味甘,具有滋肾益气、祛风解毒、补气虚、益精血、暖腰膝、利小便等作用。鸽肾结构与人肾脏较为相似,含有人肾脏所需要的多种营养物质,相较于其他动物肾脏,滋补效果更加明显;将其制成冻干粉,可在最大限度地保留其有效成分。
肉苁蓉味甘、性温,归肾、大肠经,其富含人体所需微量元素和十几种氨基酸,并且含有苯乙醇苷类、环烯醚萜类、木脂素类、多糖、生物碱等多种活性成分,可补肾阳、益精血、润肠道。
黑豆性平、味甘,入脾、肾经,具有补肾益阴、健脾利湿、除热解毒的功效;黑豆含有丰富的维生素、黄酮、蛋黄素、黑色素、卵磷脂等物质,其中B族维生素和维生素E含量高,有利于清除体内自由基,减少皮肤皱纹,达到养颜美容的效果;而异黄酮和卵磷脂可抗动脉硬化、降胆固醇,防止血管硬化。
黑米性平、味甘,具有开胃益中、健脾活血的功效;其富含蛋白质、碳水化合物、B族维生素、维生素E、钙、磷、钾、镁、铁、锌等营养元素,可提高机体对铁元素的吸收,改善贫血症状。
黑木耳味甘、性平,可补气养血,在本发明中配合黑豆、黑米可提高对肾脏的滋补作用,进而提高排毒解毒功效;此外,通过肾经的充盈可间接补充肝血,进而实现解毒、明目的效果。
松花粉味甘、性温,具有祛风益气、收湿止血的功效,在本申请中可辅助鸽肾冻干粉、肉苁蓉、黑豆、黑米、黑木耳,利尿排毒,减轻肾脏的负担,调节患者失常的免疫机能,改善患者体质。
莲子味甘、性平,具有养心安神明目、止泻固精、益肾止带、滋补元气的功效。其所含氧化黄心树宁碱具有防癌抗癌的功效。
综上,本发明通过对上述几种温和的药食同源成分进行配伍,可滋阴养血、生津润燥,养颜抗衰,适于肝肾阴血不足、津亏消渴、肠燥等症。
优选地,一种治疗肾病的组合物,包括以下重量份的原料:
鸽肾冻干粉35份、肉苁蓉10份、黑豆10份、黑米15份、黑木耳20份、松花粉5份和莲子5份。
上述治疗肾病的组合物的制备方法,包括以下步骤:
(1)制备鸽肾冻干粉:
对新鲜鸽肾进行匀浆,匀浆液于-70℃--50℃冷冻干燥,粉碎成微粉,得鸽肾冻干粉;
(2)分别对黑豆、黑米、莲子进行炒制,使黑豆、黑米、莲子含水量小于15%;
(3)分别对黑木耳、肉苁蓉以及炒制后的黑豆、黑米、莲子进行粉碎;
(4)将鸽肾冻干粉与其他物料混合。
对黑豆、黑米、莲子进行炒制,使黑豆、黑米、莲子熟化,利于营养吸收,可减低对胃肠道的刺激。
优选地,步骤(3)中粉碎细度为过100目筛。对原料进行适当粉碎,有利于活性成分的吸收。
优选地,还包括步骤(5):将步骤(4)获得的混合物压片。
经由上述的技术方案可知,本发明组合物可滋阴养血,改善肾脏环境,既可补充肾阴,又可补充肾阳,对肾脏损伤引起各种症状疗效显著。
具体实施方式
下面将对本发明实施例中的技术方案进行清楚、完整地描述,显然,所描述的实施例仅仅是本发明一部分实施例,而不是全部的实施例。基于本发明中的实施例,本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例,都属于本发明保护的范围。
实施例1
一种治疗肾病的组合物,包括以下重量份的原料:
鸽肾冻干粉35份、肉苁蓉10份、黑豆10份、黑米15份、黑木耳20份、松花粉5份和莲子5份。
制备方法:
(1)制备鸽肾冻干粉:
对新鲜鸽肾进行匀浆,匀浆液于-60℃冷冻干燥,粉碎成微粉,得鸽肾冻干粉;
(2)分别对黑豆、黑米、莲子进行炒制,使黑豆、黑米、莲子含水量小于15%;
(3)分别对黑木耳、肉苁蓉以及炒制后的黑豆、黑米、莲子进行粉碎,过;
(4)将鸽肾冻干粉与其他物料混合。
(5)将步骤(4)获得的混合物压片。
实施例2
鸽肾冻干粉33份、肉苁蓉15份、黑豆8份、黑米20份、黑木耳18份、松花粉10份和莲子3份。
制备方法:
(1)制备鸽肾冻干粉:
对新鲜鸽肾进行匀浆,匀浆液于-60℃冷冻干燥,粉碎成微粉,得鸽肾冻干粉;
(2)分别对黑豆、黑米、莲子进行炒制,使黑豆、黑米、莲子含水量小于15%;
(3)分别对黑木耳、肉苁蓉以及炒制后的黑豆、黑米、莲子进行粉碎,过;
(4)将鸽肾冻干粉与其他物料混合。
(5)将步骤(4)获得的混合物压片。
实施例3
鸽肾冻干粉40份、肉苁蓉8份、黑豆15份、黑米13份、黑木耳25份、松花粉3份和莲子10份。
制备方法:
(1)制备鸽肾冻干粉:
对新鲜鸽肾进行匀浆,匀浆液于-60℃冷冻干燥,粉碎成微粉,得鸽肾冻干粉;
(2)分别对黑豆、黑米、莲子进行炒制,使黑豆、黑米、莲子含水量小于15%;
(3)分别对黑木耳、肉苁蓉以及炒制后的黑豆、黑米、莲子进行粉碎,过100目筛;
(4)将鸽肾冻干粉与其他物料混合。
(5)将步骤(4)获得的混合物压片。
对比例1
一种治疗肾病的组合物,包括以下重量份的原料:
肉苁蓉10份、黑豆45份、黑米15份、黑木耳20份、松花粉5份和莲子5份。
制备方法:
分别对黑豆、黑米、莲子进行炒制,使黑豆、黑米、莲子含水量小于15%;分别对黑木耳、肉苁蓉以及炒制后的黑豆、黑米、莲子进行粉碎,过100目筛;各物料混合,压片。
对比例2
一种治疗肾病的组合物,包括以下重量份的原料:
猪肾冻干粉35份、肉苁蓉10份、黑豆10份、黑米15份、黑木耳20份、松花粉5份和莲子5份。
制备方法:
(1)制备鸽肾冻干粉:
对新鲜猪肾进行匀浆,匀浆液于-60℃冷冻干燥,粉碎成微粉,得猪肾冻干粉;
(2)分别对黑豆、黑米、莲子进行炒制,使黑豆、黑米、莲子含水量小于15%;
(3)分别对黑木耳、肉苁蓉以及炒制后的黑豆、黑米、莲子进行粉碎,过;
(4)将猪肾冻干粉与其他物料混合。
(5)将步骤(4)获得的混合物压片。
使用实施例1以及对比例1-3制备的组合物,对4组肾脏损伤患者进行治疗,每日2次,每日服用3片,2个月后统计治疗效果。
各组肾脏损伤患者症状如下:
1组:糖尿病肾病,尿蛋白含量>150mg/24h尿液;
2组:尿蛋白含量>1g/24h尿液,血浆白蛋白<30g/L;
3组:尿蛋白含量>3.5g/24h尿液,血浆白蛋白<25g/L,高血脂,并伴有水肿;
4组:尿蛋白含量>1g/24h尿液,血尿;
疗效评定标准如下:
治愈:症状、体征、实验室检查基本正常;
有效:症状、体征减轻,实验室检查有改善;
无效:症状无改变。
结果如表1-4所示。
表1:1组治疗效果
组别 | 治愈 | 有效 | 无效 |
实施例1 | 8 | 2 | 0 |
对比例1 | 3 | 4 | 3 |
对比例2 | 5 | 3 | 2 |
表2:2组治疗效果
组别 | 治愈 | 有效 | 无效 |
实施例1 | 6 | 4 | 0 |
对比例1 | 2 | 5 | 3 |
对比例2 | 3 | 6 | 1 |
表3:3组治疗效果
表4:4组治疗效果
组别 | 治愈 | 有效 | 无效 |
实施例1 | 5 | 4 | 1 |
对比例1 | 2 | 6 | 2 |
对比例2 | 3 | 6 | 1 |
本说明书中各个实施例采用递进的方式描述,每个实施例重点说明的都是与其他实施例的不同之处,各个实施例之间相同相似部分互相参见即可。
对所公开的实施例的上述说明,使本领域专业技术人员能够实现或使用本发明。对这些实施例的多种修改对本领域的专业技术人员来说将是显而易见的,本文中所定义的一般原理可以在不脱离本发明的精神或范围的情况下,在其它实施例中实现。因此,本发明将不会被限制于本文所示的这些实施例,而是要符合与本文所公开的原理和新颖特点相一致的最宽的范围。
Claims (5)
1.一种治疗肾病的组合物,其特征在于,包括以下重量份的原料:
鸽肾冻干粉33-40份、肉苁蓉8-15份、黑豆8-15份、黑米13-20份、黑木耳18-25份、松花粉3-10份和莲子3-10份。
2.根据权利要求1所述的一种治疗肾病的组合物,其特征在于,包括以下重量份的原料:
鸽肾冻干粉35份、肉苁蓉10份、黑豆10份、黑米15份、黑木耳20份、松花粉5份和莲子5份。
3.权利要求1或2所述治疗肾病的组合物的制备方法,其特征在于,包括以下步骤:
(1)制备鸽肾冻干粉:
对新鲜鸽肾进行匀浆,匀浆液于-70℃--50℃冷冻干燥,粉碎成微粉,得鸽肾冻干粉;
(2)分别对黑豆、黑米、莲子进行炒制,使黑豆、黑米、莲子含水量小于15%;
(3)分别对黑木耳、肉苁蓉以及炒制后的黑豆、黑米、莲子进行粉碎;
(4)将鸽肾冻干粉与其他物料混合。
4.根据权利要求3所述的治疗肾病的组合物的制备方法,其特征在于,
步骤(3)中粉碎细度为过100目筛。
5.根据权利要求3所述的治疗肾病的组合物的制备方法,其特征在于,
还包括步骤(5):将步骤(4)获得的混合物压片。
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Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109260363A (zh) * | 2018-11-27 | 2019-01-25 | 郑州金鸽生物技术开发有限公司 | 一种治疗心脏病的药物及其制备方法 |
CN109316589A (zh) * | 2018-11-27 | 2019-02-12 | 郑州金鸽生物技术开发有限公司 | 一种治疗胃病的药物及其制备方法 |
CN110237124A (zh) * | 2019-07-26 | 2019-09-17 | 四川佰利联营销策划有限公司 | 一种肉苁蓉炮制配方及工艺 |
-
2020
- 2020-10-26 CN CN202011156751.4A patent/CN112245537A/zh active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109260363A (zh) * | 2018-11-27 | 2019-01-25 | 郑州金鸽生物技术开发有限公司 | 一种治疗心脏病的药物及其制备方法 |
CN109316589A (zh) * | 2018-11-27 | 2019-02-12 | 郑州金鸽生物技术开发有限公司 | 一种治疗胃病的药物及其制备方法 |
CN110237124A (zh) * | 2019-07-26 | 2019-09-17 | 四川佰利联营销策划有限公司 | 一种肉苁蓉炮制配方及工艺 |
Non-Patent Citations (5)
Title |
---|
《大众医学》编辑部: "《家庭真验方 小药方大功效》", 31 August 2013, 上海科学技术出版社 * |
康国剑: "《失传的营养学 远离疾病》", 30 November 2014, 江西科学技术出版社 * |
李清亚: "《家庭补汤》", 31 July 2008, 金盾出版社 * |
欧军: "药食同源说黑米", 《药膳食疗研究》 * |
涂恒刚: "不拘一格做鸽肴", 《美食》 * |
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