CN112245361A - Children toothpaste for preventing decayed teeth and preparation method thereof - Google Patents
Children toothpaste for preventing decayed teeth and preparation method thereof Download PDFInfo
- Publication number
- CN112245361A CN112245361A CN202011263569.9A CN202011263569A CN112245361A CN 112245361 A CN112245361 A CN 112245361A CN 202011263569 A CN202011263569 A CN 202011263569A CN 112245361 A CN112245361 A CN 112245361A
- Authority
- CN
- China
- Prior art keywords
- toothpaste
- children
- content
- xylitol
- paste
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Oncology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Dermatology (AREA)
- Communicable Diseases (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Inorganic Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Abstract
The invention provides a children toothpaste for preventing decayed teeth and a preparation method thereof. A children toothpaste for preventing dental caries is prepared from sodium fluoride, xylitol, flos Lonicerae extract (chlorogenic acid) and toothpaste adjuvant; 0.2-0.6kg/250kg of sodium fluoride, 0.2-0.6kg/250kg of xylitol and 0.5-4kg/250kg of honeysuckle extract (chlorogenic acid). The children toothpaste has a certain effect on preventing decayed teeth, also has the effects of resisting bacteria, enhancing immunity and the like, has sweet strawberry fragrance, and can bring comfortable experience to children.
Description
Technical Field
The invention relates to the field of toothpaste, in particular to children toothpaste for preventing decayed teeth and a preparation method thereof.
Background
The toothpaste is a common cleaning product in daily life of people, and along with the development of science and technology, various kinds of toothpaste have been researched and produced at present for people with different requirements to select.
Caries is a common disease and frequently encountered disease which affect the health of residents in China, not only affects the physiological functions and the appearance of chewing, pronunciation and the like, but also has close relationship with general diseases such as heart disease, diabetes, digestive system diseases and the like. 80% of children suffer from dental caries, bring pain to patients and seriously affect the daily life of the patients.
In view of the above, the present invention is particularly proposed.
Disclosure of Invention
The first purpose of the invention is to provide the children toothpaste for preventing the decayed teeth, which has a certain effect on preventing the decayed teeth, also has the efficacies of antibiosis, immunity enhancement and the like, has sweet strawberry fragrance, and can bring comfortable experience for children.
The second purpose of the invention is to provide the preparation method of the children toothpaste, which has simple process and does not involve complex procedures and expensive equipment, so that the preparation method has low manufacturing cost and easy industrial popularization, and can be realized by adopting a traditional toothpaste production line.
In order to solve the technical problems, the invention provides the following technical scheme:
a children toothpaste for preventing dental caries is prepared from sodium fluoride, xylitol, flos Lonicerae extract (chlorogenic acid) and toothpaste adjuvant;
the content of the sodium fluoride is preferably 0.2-0.6kg/250kg, preferably 0.3-0.6kg/250kg, preferably 0.2-0.5kg/250 kg; the content of xylitol in the toothpaste is preferably 0.2-0.6kg/250kg, preferably 0.2-0.5kg/250kg, preferably 0.25-0.5kg/250 kg; the content of flos Lonicerae extract (chlorogenic acid) in the toothpaste is preferably 0.5-4kg/250kg, preferably 0.5-3kg/250kg, preferably 1-3kg/250 kg. The three components have strong pertinence to the prevention of the decayed tooth under the synergistic action, and have obvious curative effect and quick response compared with the prior toothpaste, and the effect can be achieved within one week, thereby reaching the effective rate of 100 percent.
In addition, the toothpaste also has the effects of resisting bacteria, enhancing immunity and the like, and has a remarkable curative effect.
The auxiliary materials for the toothpaste comprise a sweetening agent, a thickening agent, a surfactant, a humectant, an aromatic and an abrasive.
The thickening agent is dispersed and swelled in the liquid phase of the toothpaste to form a stable colloid to suspend the solid phase of the toothpaste and prevent the separation of the solid phase component and the liquid phase component in the toothpaste. The main functions are as follows: (1) the toothpaste has proper viscosity and consistency, no sense of stickiness and good flowing property. (2) The toothpaste has the skeleton, and the extruded toothpaste can stay on the toothbrush and cannot collapse, so that the toothpaste has good strip forming performance. (3) The toothpaste is easy to disperse during tooth brushing and has good dispersion performance. (4) Good stability, difficult biodegradation, stable paste body without layering during storage, no separation of water, no influence on the smell and color of the toothpaste, and good stability. (5) The paste is fine and glossy, the grinding material is uniformly dispersed, and the paste is not bonded and does not return to be coarse. (6) Has good compatibility with other components in the toothpaste, especially active substances, and has good compatibility.
The surfactant acts as a cleaning and foaming agent.
The humectant is a raw material component which is used in toothpaste and has the functions of keeping the moisture of the toothpaste, maintaining the fluidity of the toothpaste and lowering the freezing point, and is convenient for production and processing and is used by consumers. The main functions are as follows:
(1) the toothpaste keeps moisture of the paste body, and when the toothpaste is exposed in the air, the moisture can be prevented from evaporating, so that the toothpaste at the pipe orifice is not easy to dry and is easy to extrude;
(2) maintaining the rheological property of the paste;
(3) the freezing point of the toothpaste is lowered;
(4) the azeotropic point of the toothpaste is improved, when the toothpaste is frozen and then melted, the water in the paste body can not be separated, and the paste body is still stable even at high temperature.
The aromatic agent can improve user experience and cover off-flavor.
The abrasive is a solid raw material component which can be used together with a toothbrush in toothpaste to wipe off tartar on the surface of teeth and relieve foreign substances such as tooth stain, dental plaque, dental calculus and the like.
In addition, the auxiliary material for the toothpaste also comprises one or more of edible pigment and preservative.
Preferably, the sweetener is one or two of sucralose and stevioside, and the preferable weight mixing ratio is 2: 3-4, preferably 2.5: 3-4, the content of the sweetening agent in the children toothpaste is preferably 0.5-0.7 kg/250kg, preferably 0.6-0.7 kg/250kg, preferably 0.63-0.7 kg/250 kg;
preferably, the thickening agent is one or two of carboxymethyl cellulose and carrageenan, the preferable weight mixing ratio is 1-1.5:0.2-0.3, and the content of the thickening agent in the children toothpaste is preferably 1.5-2kg/250kg, preferably 1.6-2kg/250 kg;
preferably, the surfactant is one or two of sodium dodecyl sulfate and lauryl alcohol, the preferred mixing ratio is 4-5:1-1.5 by weight, and the content of the surfactant in the children toothpaste is preferably 5.5-7kg/250kg, preferably 5.5-8kg/250kg, preferably 5.7-7kg/250 kg;
preferably, the humectant is sorbitol, and the content of the humectant in the children toothpaste is preferably 180kg/250kg, preferably 165 kg/250kg, preferably 162 kg/250 kg;
preferably, the aromatic is one or a mixture of WS-23 and peppermint essence, and the content of the aromatic in the children toothpaste is preferably 2.5-3.5kg/250kg, preferably 2.9-3.5kg/250 kg;
preferably, the abrasive is silicon dioxide, preferably a mixture of H-type silicon dioxide and mixed silicon dioxide, and the content of the abrasive in the children toothpaste is preferably 45-55kg/250kg, preferably 48-55kg/250 kg;
preferably, the content of the edible pigment in the children toothpaste is 0.005-0.008kg/250kg and 0.005-0.007kg/250 kg.
The children toothpaste is simple to prepare, and the existing toothpaste production process can be adopted, or:
mixing all the materials in water to obtain paste;
the forming into a paste is preferably carried out in a vacuum paste machine.
Selecting a specific mixing sequence according to the type of the selected auxiliary materials, wherein the mixing sequence is basically as follows:
adding sweetening agent, sodium fluoride, xylitol, flos Lonicerae extract (chlorogenic acid), thickener, friction agent, and surfactant, mixing with vacuum paste making machine before adding surfactant, absorbing surfactant, and adding aromatic.
In summary, compared with the prior art, the invention achieves the following technical effects:
(1) the sodium fluoride, the xylitol and the honeysuckle extract (chlorogenic acid) are introduced, so that the effects of preventing decayed teeth and decayed teeth are enhanced, and the pertinence is strong;
(2) the toothpaste also has the auxiliary effects of resisting bacteria, enhancing immunity and the like;
(3) the auxiliary materials are properly selected, so that the halitosis is obviously improved, and the cleaning effect is obvious;
(4) the preparation method has simple flow, does not relate to complex procedures and expensive equipment, has low manufacturing cost, is easy for industrialized popularization, and can be realized by adopting the production line of the traditional toothpaste.
Detailed Description
The technical solutions of the present invention will be described clearly and completely with reference to the following detailed description, but those skilled in the art will understand that the following described examples are some, not all, of the examples of the present invention, and are only used for illustrating the present invention, and should not be construed as limiting the scope of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
Example 1
Firstly, preparing toothpaste
The raw material composition of the toothpaste is shown in table 1.
TABLE 1
Name of material | Number of weighings kg |
Pure water | 12.43 |
Sucralose | 0.25 |
Stevioside | 0.38 |
Sodium fluoride | 0.38 |
Xylitol, its preparation method and use | 0.25 |
Honeysuckle extract (chlorogenic acid) | 0.25 |
Carmine | 0.007 |
CMCIH9 sodium carboxymethylcellulose | 1.375 |
3189 Carrageenan | 0.25 |
Sodium dodecyl sulfate | 4.5 |
Lauryl alcohol | 1.25 |
WS-23 | 0.13 |
Strawberry essence | 2.75 |
Sorbitol | 175 |
Water (W) | The balance (until the total weight of the materials is 250 kg) |
Silicon dioxide (H) | 5 |
Silica (Mixed type) | 45 |
A. Weighing sorbitol required by a single pot by using a metering barrel corresponding to the water phase pot, putting the sorbitol into the water phase pot, starting the water phase pot, stirring, adding sucralose, stevioside, sodium fluoride, xylitol, a honeysuckle extract (chlorogenic acid) and a carmine water solution (the pot for preparing the solution can be washed by a proper amount of pure water, and adding a washing solution into the water phase pot to avoid raw material loss in the preparation process) into the water phase pot, and stirring.
B. And weighing the residual pure water for later use.
C. Starting the vacuum paste making machine and the water chilling unit, starting the vacuum pump, and controlling the feeding vacuum degree to be-0.8 MPa. Pumping the pre-dispersion liquid obtained by the step A into a vacuum paste making machine, simultaneously starting a scraper, putting the ultrapure water prepared by the step B into a water phase pot (dripping the water phase pot) of the step A, pumping the ultrapure water into the paste making machine, then starting a vacuum pump, pumping the vacuum to-0.88 Mpa, closing the vacuum pump, and continuously stirring for 5 min. So that the liquid material is uniformly dispersed.
D. The discharge valve of the powder stirring hopper is opened (the valve is opened to the position of 1/3), and the powder feeding valve of the paste making machine is opened to start feeding powder. Stopping feeding when the vacuum degree is reduced to-0.4 Mpa, timing and stirring, simultaneously starting the vacuum pump, vacuumizing to-0.88 Mpa, closing the vacuum pump, and continuing stirring for 3 min. Repeating the steps for 2 times, completely sucking all the silicon dioxide into the vacuum paste making machine, and timing and stirring for 5min after the last material suction is finished.
E. Opening an emptying valve, closing the emptying valve when the vacuum degree is reduced to-0.8 Mpa, sucking sodium dodecyl sulfate, controlling the vacuum degree to be not lower than-0.4 Mpa, and adding lauryl alcohol into a water phase pot to suck the paste. Then, the vacuum was pumped to-0.88 MPa, and the stirring was timed for 20min (in the process, the vacuum pump was always turned on).
F. Pouring the rest adjuvants into essence hopper, reducing vacuum degree to 0.8Mpa, sucking the essence mixed solution in the essence hopper into paste making machine, starting vacuum pump to maintain vacuum degree to-0.88 Mpa, stirring for 10min (the vacuum pump is always on in the process). After 10min, the stirring is closed, and the scraper is continuously started for stirring for 5 min. And finishing the paste preparation. The vacuum was broken and samples were taken and tested at 5 g. And after the inspection is qualified, the mixture is thrown into a paste storage tank to wait for filling.
Example 2
The difference from the example 1 lies in the content of sodium fluoride, xylitol and honeysuckle extract is different:
the content of the sodium fluoride is preferably 0.2-0.6kg/250kg, preferably 0.3-0.6kg/250kg, preferably 0.2-0.5kg/250 kg; the content of xylitol in the toothpaste is preferably 0.2-0.6kg/250kg, preferably 0.2-0.5kg/250kg, preferably 0.25-0.5kg/250 kg; the content of flos Lonicerae extract (chlorogenic acid) in the toothpaste is preferably 0.5-4kg/250kg, preferably 0.5-3kg/250kg, preferably 1-3kg/250 kg.
The rest steps and the content of the auxiliary materials in the toothpaste are the same as the example 1.
Example 3
The difference from the example 1 lies in the content of sodium fluoride, xylitol and honeysuckle extract is different:
the content of the sodium fluoride is preferably 0.2-0.6kg/250kg, preferably 0.3-0.6kg/250kg, preferably 0.2-0.5kg/250 kg; the content of xylitol in the toothpaste is preferably 0.2-0.6kg/250kg, preferably 0.2-0.5kg/250kg, preferably 0.25-0.5kg/250 kg; the content of flos Lonicerae extract (chlorogenic acid) in the toothpaste is preferably 0.5-4kg/250kg, preferably 0.5-3kg/250kg, preferably 1-3kg/250 kg. The rest steps and the content of the auxiliary materials in the toothpaste are the same as the example 1.
Example 4
The difference from the example 1 lies in the content of sodium fluoride, xylitol and honeysuckle extract is different:
the content of the sodium fluoride is preferably 0.2-0.6kg/250kg, preferably 0.3-0.6kg/250kg, preferably 0.2-0.5kg/250 kg; the content of xylitol in the toothpaste is preferably 0.2-0.6kg/250kg, preferably 0.2-0.5kg/250kg, preferably 0.25-0.5kg/250 kg; the content of flos Lonicerae extract (chlorogenic acid) in the toothpaste is preferably 0.5-4kg/250kg, preferably 0.5-3kg/250kg, preferably 1-3kg/250 kg. The rest steps and the content of the auxiliary materials in the toothpaste are the same as the example 1.
Example 5
In this example, the sources of the sodium fluoride, xylitol and honeysuckle extract used in example 1 are the same, the difference is that the contents of the sodium fluoride, xylitol, honeysuckle extract and the auxiliary materials of the toothpaste are different, and the compatibility is shown in table 2.
TABLE 2
Name of material | Weighing quantity kg |
Pure water | 7.25 |
Sucralose | 0.25 |
Stevioside | 0.45 |
Sodium fluoride | 0.4 |
Xylitol, its preparation method and use | 0.3 |
Honeysuckle extract (chlorogenic acid) | 20 |
Fruit green | 0.007 |
CMCIH9 sodium carboxymethylcellulose | 1.5 |
3189 Carrageenan | 0.5 |
Sodium dodecyl sulfate | 5 |
Lauryl alcohol | 2 |
WS-23 | 0.5 |
Double mint essence | 3.0 |
Sorbitol | 170 |
Water (W) | The balance (until the total weight of the materials is 250 kg) |
Silicon dioxide (H) | 7 |
Silica (Mixed type) | 48 |
The rest of the procedure was the same as in example 1.
Experiment of
The caries treatment effect is as follows:
the test method comprises the following steps: pure Wistar white rats with half male and female bodies and 55 +/-5 g of weight are selected and evenly divided into a plurality of groups, each group comprises 20 bacteria, each group corresponds to one embodiment, streptococcus mutans is cultured in TSB enrichment solution (the culture density is 50 +/-5/mL), the bacteria are cultured for 24 hours, then the bacteria are smeared in tooth sockets of lower molar teeth of the white rats by cotton sticks (inoculated once per week), the white rats are fed with cane sugar, the white rats are raised for two months, wherein during the raising period, one group is smeared with one toothpaste (0.3mL of toothpaste) in the tooth sockets of the lower molar teeth of the white rats at 6:00 a day in the morning by the cotton sticks, the rest group is not smeared with the toothpaste (a control group), and the occurrence condition of dental caries is observed, and the result is shown in Table 3.
TABLE 3 dental caries treatment effect of the toothpaste of the present invention
Examples | Incidence of dental caries | Number of decayed teeth in mice | Number of caries |
Example 1 | 0 | 0 | 0 |
Example 2 | 5% | 0.12 | 1 |
Example 3 | 5% | 0.15 | 1 |
Example 4 | 5% | 0.13 | 1 |
Example 5 | 5% | 0.21 | 2 |
Control group | 96% | 2.41 | 47 |
Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present invention.
Claims (4)
1. A children toothpaste for preventing dental caries is characterized in that the toothpaste is mainly prepared from sodium fluoride, xylitol, honeysuckle extract (chlorogenic acid) and toothpaste auxiliary materials;
the children's toothpaste according to claim 1, wherein the sodium fluoride is preferably present in an amount of 0.2-0.6kg/250kg, preferably 0.3-0.6kg/250kg, preferably 0.2-0.5kg/250 kg;
the children's toothpaste according to claim 1, wherein the content of xylitol in the children's toothpaste is preferably 0.2-0.6kg/250kg, preferably 0.2-0.5kg/250kg, preferably 0.25-0.5kg/250 kg;
the children's toothpaste according to claim 1, wherein the honeysuckle extract (chlorogenic acid) is contained in the children's toothpaste in an amount of preferably 0.5-4kg/250kg, preferably 0.5-3kg/250kg, preferably 1-3kg/250 kg;
the children's toothpaste according to claim 1, wherein the auxiliary materials for children's toothpaste comprise a sweetener, a thickener, a surfactant, a humectant, an aromatic and an abrasive.
2. The children's toothpaste according to claim 1, wherein the children's toothpaste further comprises one or more of edible pigments.
3. The children's toothpaste according to claim 1, wherein the sweetener is one or both of sucralose and stevioside, preferably in a weight mixing ratio of 2: 3-4, preferably 2.5: 3-4, the content of the sweetening agent in the children toothpaste is preferably 0.5-0.7 kg/250kg, preferably 0.6-0.7 kg/250kg, preferably 0.63-0.7 kg/250 kg;
preferably, the thickening agent is one or two of carboxymethyl cellulose and carrageenan, the preferable weight mixing ratio is 1-1.5:0.2-0.3, and the content of the thickening agent in the children toothpaste is preferably 1.5-2kg/250kg, preferably 1.6-2kg/250 kg;
preferably, the surfactant is one or two of sodium dodecyl sulfate and lauryl alcohol, the preferred mixing ratio is 4-5:1-1.5 by weight, and the content of the surfactant in the children toothpaste is preferably 5.5-7kg/250kg, preferably 5.5-8kg/250kg, preferably 5.7-7kg/250 kg;
preferably, the humectant is sorbitol, and the content of the humectant in the children toothpaste is preferably 180kg/250kg, preferably 165 kg/250kg, preferably 162 kg/250 kg;
preferably, the aromatic is one or the mixture of WS-23 and strawberry essence, the content of the aromatic in the children toothpaste is preferably 2.5-3.5kg/250kg, preferably 2.9-3.5kg/250kg,
preferably, the abrasive is silica, preferably a mixture of type H silica and mixed silica, and the content of the abrasive in the children's toothpaste is preferably 45-55kg/250kg, preferably 48-55kg/250 kg.
4. The children's toothpaste according to claim 3, wherein the edible pigment is carmine, and the content of the edible pigment in the children's toothpaste is preferably 0.005-0.008kg/250kg, 0.005-0.007kg/250 kg;
the method for preparing children's toothpaste according to any one of claims 1 to 4, wherein all the raw materials are mixed in water to form a paste;
the forming into a paste is preferably carried out in a vacuum paste machine.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202011263569.9A CN112245361A (en) | 2020-11-12 | 2020-11-12 | Children toothpaste for preventing decayed teeth and preparation method thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202011263569.9A CN112245361A (en) | 2020-11-12 | 2020-11-12 | Children toothpaste for preventing decayed teeth and preparation method thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CN112245361A true CN112245361A (en) | 2021-01-22 |
Family
ID=74265831
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202011263569.9A Pending CN112245361A (en) | 2020-11-12 | 2020-11-12 | Children toothpaste for preventing decayed teeth and preparation method thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN112245361A (en) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105997743A (en) * | 2016-07-17 | 2016-10-12 | 张学健 | Anti-allergic toothpaste prepared from natural plant components |
CN106890103A (en) * | 2017-03-06 | 2017-06-27 | 广州薇美姿实业有限公司 | A kind of toothpaste suitable for pump type packaging material and preparation method thereof |
CN109077981A (en) * | 2018-11-01 | 2018-12-25 | 贵州苗老藤生物养生有限公司 | A kind of Chinese herbal toothpaste and preparation method thereof |
-
2020
- 2020-11-12 CN CN202011263569.9A patent/CN112245361A/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105997743A (en) * | 2016-07-17 | 2016-10-12 | 张学健 | Anti-allergic toothpaste prepared from natural plant components |
CN106890103A (en) * | 2017-03-06 | 2017-06-27 | 广州薇美姿实业有限公司 | A kind of toothpaste suitable for pump type packaging material and preparation method thereof |
CN109077981A (en) * | 2018-11-01 | 2018-12-25 | 贵州苗老藤生物养生有限公司 | A kind of Chinese herbal toothpaste and preparation method thereof |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR101955468B1 (en) | Preparing method for toothpaste composition comprising natural extracts | |
CN106562923B (en) | Oral care composition containing profitable probliotics and its application in toothpaste | |
US11986551B2 (en) | Sedative laced toothpaste | |
JP2008069138A (en) | Oral composition | |
CN106726773A (en) | A kind of whitening stain removing toothpaste and preparation method thereof | |
CN112691057B (en) | Compound efficacy toothpaste and preparation method thereof | |
US20060193795A1 (en) | Appetite suppressant mouth spray | |
CN101292943B (en) | Nanometer zinc oxide toothpaste | |
CN106581159B (en) | Oral care composition for children and morning and evening benefiting combined toothpaste for children | |
AU2002256299B2 (en) | Stable herbal dentifrice | |
CN109077981A (en) | A kind of Chinese herbal toothpaste and preparation method thereof | |
JP5754711B2 (en) | Oral hygiene composition effective in promoting salivation and oral care product | |
CN114272196A (en) | Composition for regulating oral flora balance, preparation method and application thereof | |
CN108670872A (en) | Tasty and refreshing gas toothpaste | |
CN109276520A (en) | A kind of firm more foam bamboo salt toothpaste formulas | |
CN112245361A (en) | Children toothpaste for preventing decayed teeth and preparation method thereof | |
CN113081893A (en) | Oral bacteriostatic composition, preparation method and application thereof | |
US20040115138A1 (en) | Stable herbal dentifrice | |
KR20120050104A (en) | Dentifrice composition containing mastic extracts and method for preparing the same | |
WO2020000771A1 (en) | Bamboo vinegar toothpaste and preparation method therefor | |
CN109846794B (en) | Composition, microsphere containing composition and preparation method of microsphere | |
CN111888304B (en) | Anti-inflammation and anti-allergy toothpaste and preparation method thereof | |
CN108743419A (en) | Antibacterial removes stain toothpaste | |
JP7340191B2 (en) | Oral care composition containing sweet potato-derived sweet potato honey or sweet potato supernatant | |
WO2003086359A1 (en) | Tea polyphenol buccal tablet for preventing and treating tooth decay and its preparing method |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20210122 |
|
WD01 | Invention patent application deemed withdrawn after publication |