CN112237191A

CN112237191A - Insecticidal composition and application thereof in pest control

Info

Publication number: CN112237191A
Application number: CN201910642424.0A
Authority: CN
Inventors: 徐海燕; 顾成千; 苑志军; 樊贵利; 王鸿宾; 卜德红; 于静静
Original assignee: Shanghai Shengnong Pesticide Co Ltd
Current assignee: Shanghai Shengnong Pesticide Co Ltd
Priority date: 2019-07-16
Filing date: 2019-07-16
Publication date: 2021-01-19

Abstract

The invention relates to a pesticidal composition and application thereof in controlling pests, comprising the following components: a component A and a component B; the component A is selected from any one or the combination of two of 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole; the component B is selected from any one or the combination of two of spinetoram and emamectin benzoate; and the weight ratio of the A component to the B component is 80: 1-1: 80. the insecticidal composition has the advantages that two compounds with different action mechanisms are compounded, so that the resistance of pests to the component A is delayed, the action range is wider compared with the single action of the component A and the component B, and the insecticidal efficacy is improved; the generation of drug resistance of pests is delayed, the use times are reduced, the use amount of the insecticidal composition is reduced, and the agricultural cost of the insecticidal composition is reduced; compared with other pesticides, the pesticide composition has lower residue and is more environment-friendly.

Description

Insecticidal composition and application thereof in pest control

Technical Field

The invention relates to the technical field of pesticide compositions, in particular to an insecticidal composition and application thereof in pest control.

Background

The pesticide has a long history of use, plays a great role in the process of reforming nature of human beings, promotes the great development of agriculture and brings great economic benefits to human beings. In China, shikimic, charcoal ash, mutual and other insects are killed in the seventh century before the unit of public yuan to the fifth century before the unit of public yuan. In the natural and inorganic medicine age mainly using natural medicine and inorganic compound pesticide before 40 s of 20 th century; from the beginning of the 20 th century, the times of organic synthetic pesticides were entered. The current development situation of pesticides is as follows: developed countries have entered into variety updating from the 70 th century, and the agricultural chemicals in China have developed greatly from the 80 th century, but most of them are built and developed on the basis of imitation, and the agricultural chemicals in China are not updated until the 90 th century. However, the pesticide is still mainly used in old varieties, and the pesticide is mainly used in high-toxicity and high-residue pesticides, so that the proportion rationality of the pesticide varieties is poor, the use technical level is low, and the use amount is large, thereby causing serious environmental pollution. In the 21 st century, the practical pesticide in agricultural production gradually developed in the direction of low toxicity, high activity and good environmental compatibility.

Due to the toxicity and side effects of pesticides, a series of problems occur in the long-term use process of pesticides, such as pesticide toxicity residue, environmental pollution, ecological balance damage and the like. However, pesticides are still indispensable production data at present, and because the problems of the rapid increase of the world population and the urgent demand for agricultural products are solved, high-yield and high-efficiency agriculture rather than low-yield organic agriculture needs to be developed, and pesticides are necessary and guaranteed for high-efficiency agriculture.

The pest resistance to pesticides is one of important influencing factors influencing the using effect of pesticides in the actual process of agricultural production, and the pest resistance to pesticides means that pests have resistance to certain pesticides after the pesticides are used, and the resistance to pesticides generated by the use of the pesticides can be inherited. Due to the long-term and excessive use of chemical pesticides, pests generally have resistance to certain chemical pesticides to a certain extent after the chemical pesticides are used for a certain period of time. From the pest species, coleopteran, dipteran, and lepidopteran insects produce the most resistant species. The agricultural influence such as the reduction of the yield of agricultural products, the increase of the agricultural production cost, the rampant pests and the like can be caused by the drug resistance of the pests, and the irreversible harm can be caused to human beings and the environment due to the increased application of the pesticide. In order to solve the problem of drug resistance of pests, new drugs need to be developed or different pesticides need to be compounded to achieve the required drug effect.

Disclosure of Invention

In order to overcome various technical defects in the prior art, the inventor intends to compound a compound containing a 4-p-phenoxy phenoxymethyl structure with spinetoram or emamectin benzoate to serve as an effective component of a novel pesticide composition, so as to solve the technical problems of serious drug resistance, single application method and few types of acting pests in the prior art and obtain excellent control effect.

Accordingly, in a first aspect, the present invention provides an insecticidal composition comprising: a component A and a component B;

the component A is selected from any one or the combination of two of 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole;

the component B is selected from any one or the combination of two of spinetoram and emamectin benzoate;

and the weight ratio of the A component to the B component is 80: 1-1: 80.

preferably, the weight ratio of the a component to the B component is preferably 40: 1-1: 40, more preferably 20: 1-1: 20, or more preferably 8: 1-1: 8, or more preferably 4: 1-1: 4, or even more preferably 4: 1-1: 4.

preferably, the insecticidal composition further comprises an adjuvant and/or a carrier.

Preferably, the auxiliary agent is selected from any one or a combination of several of an emulsifier, a dispersing agent, an antifreezing agent, a thickening agent, an antifoaming agent, a stabilizing agent, a wetting agent, a filler, a capsule wall material, a pH regulator and a disintegrating agent.

The emulsifier can promote two immiscible liquids in the composition to form a stable emulsion, and is also a stabilizer of the emulsion. In the insecticidal composition provided by the invention, the emulsifier is selected from any one or combination of more of calcium dodecyl benzene sulfonate, fatty acid polyoxyethylene ether, alkylphenol polyoxyethylene sulfosuccinate, styrylphenol polyoxyethylene ether, nonylphenol polyoxyethylene ether, castor oil polyoxyethylene ether, diphenylethylphenol polyoxyethylene ether, fatty acid polyoxyethylene ester, polyoxyethylene fatty alcohol ether, polyoxyethylene fatty alcohol amine, ethylene oxide polymer and ethylene oxide and propylene oxide copolymer.

The dispersing agent is used for reducing aggregation of solid or liquid particles in a dispersion system of the composition, and when the dispersing agent is added in preparation of wettable powder, water dispersible granules, water dispersible tablets, suspending agents and oil suspending agents, the dispersing liquid and the suspending liquid are easy to form, and the relative stability of the dispersion system is kept. In the insecticidal composition provided by the invention, the dispersing agent is selected from one or a combination of a plurality of polycarboxylate, lignosulfonate, a methyl naphthalene sulfonic acid formaldehyde condensate, sodium methylene naphthalene sulfonate, epoxy polyether, sodium hexametaphosphate, alkylphenol polyoxyethylene phosphate, alkylphenol polyoxyethylene ether formaldehyde condensate sulfate, calcium alkylbenzene sulfonate, naphthalene sulfonic acid formaldehyde condensate sodium salt, alkylphenol polyoxyethylene ether, fatty amine polyoxyethylene ether, fatty acid polyoxyethylene ester and glycerin fatty acid ester polyoxyethylene ether.

The antifreezing agent is a substance for lowering the freezing point of the liquid of the composition and improving the freezing resistance. In the pesticide composition provided by the invention, the antifreezing agent is selected from any one or a combination of a plurality of ethylene glycol, propylene glycol and glycerol.

Thickeners are used to increase the viscosity of the dispersion medium in the composition to reduce the settling rate of the particles and improve the stratification of the composition liquid. In the insecticidal composition provided by the invention, the thickening agent is selected from any one or a combination of several of xanthan gum, hydroxymethyl cellulose, hydroxyethyl cellulose, methyl cellulose, magnesium aluminum silicate, polyvinyl alcohol, carboxymethyl alcohol and polyvinyl acetate.

Defoamers are used in the manufacturing process to remove excess foam. In the insecticidal composition provided by the invention, the defoaming agent is selected from silicone oil, silicone compounds and C_10-20Saturated fatty acid compound, C_8-10Any one or combination of several of fatty alcohol compounds.

Stabilizers, to increase the stability of the solution, colloid, solid, mixture, slow down the reaction, maintain chemical equilibrium, reduce surface tension, prevent light, thermal or oxidative decomposition, etc. In the insecticidal composition provided by the invention, the stabilizer is selected from any one or a combination of two of sodium citrate and resorcinol.

The wetting agent is also called penetrant, and mainly has the function of enabling solid materials in the composition to be more easily wetted by water. In the insecticidal composition provided by the invention, the wetting agent is selected from any one or a combination of more of sodium dodecyl sulfate, calcium dodecyl benzene sulfonate, alkyl naphthalene sulfonate, polyoxyethylene triphenyl ethylene phenyl phosphate, alkyl sulfonate, alkylphenol polyoxyethylene ether, polyoxyethylene polyoxypropylene block copolymer, sodium lauryl sulfate and alkylphenol polyoxyethylene formaldehyde condensate.

In the insecticidal composition provided by the invention, the filler is selected from one or more of kaolin, diatomite, bentonite, attapulgite, white carbon black, starch and light calcium carbonate.

In the insecticidal composition provided by the invention, the capsule wall material is selected from any one or a combination of more of sodium alginate, chitosan, gelatin, porous starch, urea, isocyanate and gum.

The disintegrating agent enables the tablet to be rapidly cracked into fine particles in the solution, thereby enabling the functional components to be rapidly dissolved and absorbed to play a role. In the insecticidal composition provided by the invention, the disintegrating agent is selected from one or a combination of more of bentonite, urea, ammonium sulfate, aluminum chloride, citric acid, succinic acid and sodium bicarbonate.

The pH regulator is used for regulating the pH value of the composition. In the pesticidal composition provided by the present invention, the pH adjuster is selected from any one or more of: citric acid, sodium bicarbonate, diethylamine, triisopropanolamine, phosphoric acid, glacial acetic acid.

Preferably, the carrier is selected from any one or combination of xylene, toluene, diesel oil, methanol, ethanol, n-butanol, isopropanol, solvent oil No. 150, solvent oil No. 200, dimethylformamide, dimethyl sulfoxide, methyl oleate, soybean oil, epoxidized soybean oil, corn oil, rapeseed oil, cottonseed oil, turpentine, white oil, kerosene and water.

Preferably, the formulation of the insecticidal composition is selected from any one of missible oil, aqueous emulsion, microemulsion, microcapsule suspending agent, water suspending agent, soluble liquid, wettable powder, water dispersible granule and oil suspending agent.

Preferably, the missible oil comprises the following components in parts by weight:

preferably, the aqueous emulsion comprises the following components in parts by weight:

preferably, the microemulsion comprises the following components in parts by weight:

preferably, the microcapsule suspending agent comprises the following components in parts by weight:

preferably, the water suspending agent comprises the following components in parts by weight:

preferably, the soluble liquid agent comprises the following components in parts by weight:

preferably, the wettable powder comprises the following components in parts by weight:

preferably, the water dispersible granule comprises the following components in parts by weight:

preferably, the oil suspension comprises the following components in parts by weight:

meanwhile, the second aspect of the present invention provides the use of the pesticidal composition according to the first aspect for controlling pests.

Wherein the pesticidal composition may act directly on the pest or on its environment, habitat or storage area. During application, the pesticidal composition may be applied to one or more of the stem, foliage, seeds, fruits, roots or soil of a plant.

Wherein, the plant is preferably crops (including cereals, vegetables, fruits and the like), horticultural plants, fruit trees and deep-forest plants, and is further preferably cereals and vegetable crops, such as rice, wheat, corn and Chinese cabbage. Wherein the mode of applying the insecticidal composition can be one or more of dipping, spraying, evaporating, atomizing, broadcasting, brushing, and the like.

Preferably, in the above application, the pests are nematode pests, isopod pests, coleopteran pests, lepidopteran pests, gastropod pests, orthopteran pests, plant parasitic mites, thysanopteran pests, dipteran pests, hymenopteran pests, cryptopteran pests, phthira pests, isopteran pests, hemipteran pests, tidemaphytes, parapsoria pests, and isopteran pests.

The nematode pests comprise root-rot nematodes, pseudobrachypodium praecox, praecox luxianus, praecox destructor and other root-rot nematodes, cyst nematodes such as soybean cyst nematodes and potato nematodes, root-knot nematodes such as peanut root-knot nematodes and southern root-knot nematodes, root-knot nematodes such as aphelenchoides besseyi and leaf bud nematodes, dwarf nematodes, circumpolar line nematodes, needle line nematodes, cyst nematodes, burr nematodes, strawberry upper nematodes and pine wood nematodes.

Preferably, in the above application, the pests are aphids, leafhoppers, plant hoppers, leaf beetles, wireworms, cutworms, diamond back moths, pieris rapae and rice thrips.

Preferably, in the above application, the pests are sucking mouthparts pests, including but not limited to whitefly, scale insect, thrips, plant hopper.

By adopting the technical scheme, compared with the prior art, the invention has the following technical effects:

according to the insecticidal composition, two compounds with different action mechanisms are compounded, so that the resistance of pests to the component A is delayed, the action range is wider compared with the single action of the component A and the component B, and the insecticidal efficacy is improved; the generation of drug resistance of pests is delayed, the use times of the insecticidal composition (namely the pesticide) are reduced, and the use amount of the insecticidal composition is reduced, so that the agricultural cost of the insecticidal composition is reduced; compared with other pesticides, the pesticide composition has lower residual quantity, is more environment-friendly, and has great significance for safe eating of agricultural products.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

It should be noted that the embodiments and features of the embodiments may be combined with each other without conflict.

The present invention is further illustrated by the following examples, which are not to be construed as limiting the invention.

Example 1

The method for calculating the co-toxicity coefficient of the compound agent according to the toxicity index calculates the toxicity index and the co-toxicity coefficient (CTC) of the medicament.

Theoretical virulence index (TTI) ═ Sigma (virulence index TI for each individual dose x percentage of individual doses in the mixture)

The experimental judgment basis is as follows:

when the CTC is less than or equal to 80, the composition shows antagonism, when 80< CTC is less than 120, the composition shows additive action, and when the CTC is more than or equal to 120, the composition shows synergistic action.

Reacting 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine with spinetoram according to a weight ratio of 80: 1-1: 80 to obtain a plurality of compositions, selecting the compositions corresponding to a plurality of specific weight ratios to determine the toxicity of the compositions on thrips, and the test results are shown in table 1:

TABLE 1 comparison of virulence test results for thrips

And (3) analyzing an experimental result: as can be seen from table 1:

1) 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram were mixed at 80: 1-1: within 80 weight percent, virulence indexes (ATI) were all found to be higher than the virulence index (TTI). In particular 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram in the ratio of 20: 1-1: in the weight ratio range of 20, ATI is far higher than TTI, which shows that the synergistic effect is obvious.

2) 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram were mixed at 80: 1-1: 80, the co-toxicity coefficient (CTC) is more than 80, and antagonism does not exist; 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram were mixed at 40: 1-1: 20, the CTC is higher than 120, and the obvious synergistic effect is achieved; wherein the ratio of 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine to spinetoram is 40: 1-1: 1, the CTC is highest, the synergistic effect is stronger, and particularly, the weight ratio range is 4: 1, the CTC reaches 225.94, and the synergistic effect is strongest.

3) 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram were mixed at a ratio of 1: 4-1: 80, the measured virulence index (ATI) is higher than the virulence index 41438.36 of spinetoram.

4) 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram were mixed at 80: 1-1: 20, half-Lethal Concentration (LC) on thrips with increasing spinetoram proportion₅₀) The reduction is obvious; 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram were mixed at a ratio of 1: 1-1: 80, LC of the compound composition of 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram₅₀Much lower than LC when 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine is used alone₅₀LC with spinetoram alone₅₀Comparable or lower, 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram are present in a ratio of 1: 1-1: 80 weight ratio of the composition₅₀LC significantly lower than spinetoram₅₀。

It can be seen that the present invention provides a composition of 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram, the ratio of 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine to spinetoram being in the range of 80: 1-1: 80 in a weight ratio of no antagonism and a reduction in LC₅₀(ii) a 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram were mixed at 40: 1-1: 20, 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram in a weight ratio of 40: 1-1: 1, the synergistic effect is most obvious; 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram were mixed at a ratio of 1: 1-1: 80 weight ratio of the composition₅₀Very low, the use safety is improved.

Combining the above factors, the weight ratio of 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine to spinetoram was 8: 1-1: in case 8, the best effect is obtained.

Example 2

The experimental effect calculation method and experimental judgment basis are as follows: same as in example 1.

Mixing 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram according to the weight ratio of 80: 1-1: 80 to obtain a plurality of compositions, selecting the compositions corresponding to a plurality of specific weight ratios to determine the toxicity of the compositions to armyworms, wherein the test results are shown in table 2:

TABLE 2 comparison of virulence test results for armyworm

And (3) analyzing an experimental result: as can be seen from table 2:

1) 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram were mixed at 80: 1-1: within 80 weight percent, virulence indexes (ATI) were all found to be higher than the virulence index (TTI). In particular 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram in the ratio 8: 1-1: in the weight ratio range of 20, ATI is far higher than TTI, which shows that the synergistic effect is obvious.

2) 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram were mixed at 80: 1-1: 80, the co-toxicity coefficient (CTC) is more than 80, and antagonism does not exist; 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram were mixed at 40: 1-1: 20, the CTC is higher than 120, and the obvious synergistic effect is achieved; wherein the ratio of 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine to spinetoram is 20: 1-1: 4, the CTC is highest, the synergistic effect is stronger, and particularly, the weight ratio range is 8: 1, the CTC reaches 166.36, and the synergistic effect is strongest.

3) 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram were mixed at a ratio of 1: 4-1: 20, the observed virulence indexes (ATI) are all higher than the virulence index 16508.00 of spinetoram.

4) 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram were mixed at 80: 1-1: 20, half-Lethal Concentration (LC) against armyworm with increasing ethyl spinosad ratio₅₀) The reduction is obvious; 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram were mixed at a ratio of 1: 1-1: 80 in the weight ratio range of 2-LC of chlorine-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram compound composition₅₀Much lower than LC when 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine is used alone₅₀LC with spinetoram alone₅₀Comparable or lower, 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram are present in a ratio of 1: 1-1: 20 in the weight ratio range of the composition₅₀LC significantly lower than spinetoram₅₀。

It can be seen that the present invention provides a composition of 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram, the ratio of 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine to spinetoram being in the range of 80: 1-1: 80 in a weight ratio of no antagonism and a reduction in LC₅₀(ii) a 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram were mixed at 40: 1-1: 20, 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram in a weight ratio of 40: 1-1: 4, the synergistic effect is most obvious within the weight proportion range; 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram were mixed at a ratio of 1: 4-1: 80 weight ratio of the composition₅₀Very low, the use safety is improved.

Combining the above factors, the weight ratio of 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine to spinetoram was 4: 1-1: 20, the best effect is obtained.

Example 3

Mixing 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram according to the weight ratio of 80: 1-1: 80 to obtain a plurality of compositions, selecting the compositions corresponding to a plurality of specific weight ratios to determine the toxicity of the compositions to the spodoptera exigua, wherein the test results are shown in Table 3:

TABLE 3 comparison of virulence test results for beet armyworm

And (3) analyzing an experimental result: as can be seen from table 3:

2) 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram were mixed at 80: 1-1: 80, the co-toxicity coefficient (CTC) is more than 80, and antagonism does not exist; 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram were mixed at 20: 1-1: 20, the CTC is higher than 120, and the obvious synergistic effect is achieved; wherein the ratio of 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine to spinetoram is 8: 1-1: 4, the CTC is highest, the synergistic effect is stronger, and particularly, the weight ratio range is 4: 1, the CTC reaches 191.80, and the synergistic effect is strongest.

3) 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram were mixed at a ratio of 1: 4-1: 40, the toxicity index (ATI) was found to be higher than the toxicity index 43975.00 of spinetoram.

4) 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram were mixed at 80: 1-1: 8, half-Lethal Concentration (LC) to beet armyworm with increasing ethyl spinosad ratio₅₀) The reduction is obvious; 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram were mixed at a ratio of 1: 1-1: 80, LC of the compound composition of 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram₅₀Much lower than LC when 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine is used alone₅₀LC with spinetoram alone₅₀Comparable or lower, 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram are present in a ratio of 1: 4-1: 40 in weight ratio of the composition₅₀LC significantly lower than spinetoram₅₀。

It can be seen that the present invention provides a composition of 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram, the ratio of 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine to spinetoram being in the range of 80: 1-1: 80 in a weight ratio of no antagonism and a reduction in LC₅₀(ii) a 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram were mixed at 20: 1-1: 20, 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram in a weight ratio of 8: 1-1: within the weight ratio range of 8, the synergistic effect is most obvious; 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram were mixed at a ratio of 1: 4-1: 20 in the weight ratio range of the composition₅₀Very low, the use safety is improved.

Combining the above factors, the weight ratio of 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine to spinetoram is 1: 1-1: in case 8, the best effect is obtained.

Example 4

Mixing 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and spinetoram according to the weight ratio of 80: 1-1: 80 to obtain a plurality of compositions, selecting the compositions corresponding to a plurality of specific weight ratios to determine the toxicity of the compositions on thrips, and the test results are shown in Table 4:

TABLE 4 comparison of virulence test results for thrips

And (3) analyzing an experimental result: as can be seen from table 4:

1) 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and spinetoram were reacted at a molar ratio of 40: 1-1: within 80 weight percent, virulence indexes (ATI) were all found to be higher than the virulence index (TTI). In particular 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and spinetoram in the 8: 1-1: within the weight proportion range of 80, ATI is far higher than TTI, which shows that the synergistic effect is obvious.

2) 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and spinetoram were prepared at 80: 1-1: 80, the co-toxicity coefficient (CTC) is more than 80, and antagonism does not exist; 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and spinetoram were reacted at a molar ratio of 40: 1-1: 80, the CTC is higher than 120, and the obvious synergistic effect is achieved; wherein the ratio of 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole to spinetoram is 8: 1-1: 20, the CTC is highest, the synergistic effect is strong, and particularly the weight ratio range is 4: 1, the CTC reaches 190.17, and the synergistic effect is strongest.

3) 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and spinetoram were prepared in a ratio of 1: 4-1: 80, the measured virulence index (ATI) is higher than the virulence index 39397.26 of spinetoram.

4) 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and spinetoram were prepared at 80: 1-1: 20, half-Lethal Concentration (LC) on thrips with increasing spinetoram proportion₅₀) The reduction is obvious; 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and spinetoram were prepared in a ratio of 1: 1-1: 80, LC of the compound composition of 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and spinetoram₅₀Much lower than LC when 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole is used alone₅₀LC with spinetoram alone₅₀Comparable or lower, 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and spinetoram are in the molar ratio 1: 4-1: 80 in the weight ratio range ofLC of the Compound₅₀LC significantly lower than spinetoram₅₀。

It can be seen that the present invention provides a composition of 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and spinetoram, the composition of 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and spinetoram being between 80: 1-1: 80 in a weight ratio of no antagonism and a reduction in LC₅₀(ii) a 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and spinetoram were reacted at a molar ratio of 40: 1-1: 80, 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and spinetoram are in a weight ratio of 8: 1-1: within the weight ratio range of 20, the synergistic effect is most obvious; 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and spinetoram were prepared in a ratio of 1: 1-1: 80 weight ratio of the composition₅₀Very low, the use safety is improved.

Combining the above factors, the weight ratio of 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole to spinetoram was 1: 1-1: 80, the best effect is obtained.

Example 5

Mixing 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and spinetoram according to the weight ratio of 80: 1-1: 80 to obtain a plurality of compositions, selecting the compositions corresponding to a plurality of specific weight ratios to determine the toxicity of the compositions to armyworms, and the test results are shown in table 5:

TABLE 5 comparison of virulence test results for armyworm

And (3) analyzing an experimental result: as can be seen from table 5:

1) 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and spinetoram were prepared at 80: 1-1: within 80 weight percent, virulence indexes (ATI) were all found to be higher than the virulence index (TTI). In particular 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and spinetoram in the 8: 1-1: in the weight ratio range of 20, ATI is far higher than TTI, which shows that the synergistic effect is obvious.

2) 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and spinetoram were prepared at 80: 1-1: 80, the co-toxicity coefficient (CTC) is more than 80, and antagonism does not exist; 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and spinetoram were prepared at 20: 1-1: 20, the CTC is higher than 120, and the obvious synergistic effect is achieved; wherein the ratio of 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole to spinetoram is 8: 1-1: 4, the CTC is highest, the synergistic effect is stronger, and particularly, the weight ratio range is 1: 1, the CTC reaches 177.64, and the synergistic effect is strongest.

3) 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and spinetoram were prepared in a ratio of 1: 4-1: 20, the observed virulence indexes (ATI) are all higher than the virulence index 18972.00 of spinetoram.

4) 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and spinetoram were prepared at 80: 1-1: 20, half-Lethal Concentration (LC) against armyworm with increasing ethyl spinosad ratio₅₀) The reduction is obvious; 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and spinetoram were prepared in a ratio of 1: 1-1: 80, LC of the compound composition of 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and spinetoram₅₀Much lower than LC when 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole is used alone₅₀LC with spinetoram alone₅₀Comparable or lower, 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and spinetoram are in the molar ratio 1: 4-1: 20 in the weight ratio range of the composition₅₀LC significantly lower than spinetoram₅₀。

It can be seen that the present invention provides a composition of 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and spinetoram, the composition of 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and spinetoram being between 80: 1-1: 80 in a weight ratio of no antagonism and a reduction in LC₅₀(ii) a 2-chloro-5-, ((4-phenoxyphenoxy) methyl) thiazole and spinetoram in the ratio of 20: 1-1: 20, 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and spinetoram are in a weight ratio of 8: 1-1: 4, the synergistic effect is most obvious within the weight proportion range; 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and spinetoram were prepared in a ratio of 1: 4-1: 80 weight ratio of the composition₅₀Very low, the use safety is improved.

Combining the above factors, the weight ratio of 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole to spinetoram was 8: 1-1: 20, the best effect is obtained.

Example 6

Mixing 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and spinetoram according to the weight ratio of 80: 1-1: 80 to obtain a plurality of compositions, selecting the compositions corresponding to a plurality of specific weight ratios to determine the toxicity of the compositions to the spodoptera exigua, wherein the test results are shown in Table 6:

TABLE 6 comparison of virulence test results for beet armyworm

And (3) analyzing an experimental result: as can be seen from table 6:

2) 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and spinetoram were prepared at 80: 1-1: 80, the co-toxicity coefficient (CTC) is more than 80, and antagonism does not exist; 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and spinetoram were prepared at 20: 1-1: 20, the CTC is higher than 120, and the obvious synergistic effect is achieved; wherein the ratio of 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole to spinetoram is 20: 1-1: 8, the CTC is the highest, the synergistic effect is stronger, and particularly, the weight ratio range is 4: 1, the CTC reaches 179.93, and the synergistic effect is strongest.

3) 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and spinetoram were prepared in a ratio of 1: 4-1: 80, the measured virulence index (ATI) is higher than the virulence index 38050.00 of spinetoram.

4) 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and spinetoram were prepared at 80: 1-1: 8, half-Lethal Concentration (LC) to beet armyworm with increasing ethyl spinosad ratio₅₀) The reduction is obvious; 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and spinetoram were prepared in a ratio of 1: 1-1: 80, LC of the compound composition of 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and spinetoram₅₀Much lower than LC when 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole is used alone₅₀LC with spinetoram alone₅₀Comparable or lower, 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and spinetoram are in the molar ratio 1: 4-1: 80 weight ratio of the composition₅₀LC significantly lower than spinetoram₅₀。

It can be seen that the present invention provides a composition of 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and spinetoram, the composition of 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and spinetoram being between 80: 1-1: 80 in a weight ratio of no antagonism and a reduction in LC₅₀(ii) a 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and spinetoram were prepared at 20: 1-1: 20, 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and spinetoram in a weight ratio of 20: 1-1: within the weight ratio range of 20, the synergistic effect is most obvious; 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and spinetoram were prepared in a ratio of 1: 4-1: 80 weight ratio of the composition₅₀Very low, the use safety is improved.

Combining the above factors, the weight ratio of 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole to spinetoram was 1: 1-1: 20, the best effect is obtained.

Example 7

Mixing 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and emamectin benzoate according to the proportion of 80: 1-1: 80 to obtain a plurality of compositions, selecting the compositions corresponding to a plurality of specific weight ratios to determine the toxicity of the compositions to chilo suppressalis, and the test results are shown in table 7:

TABLE 7 comparison of virulence test results against Chilo suppressalis

And (3) analyzing an experimental result: as can be seen from table 7:

1) 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and emamectin benzoate in 80: 1-1: within a weight range of 20, virulence indexes (ATI) were all found to be higher than the virulence index (TTI). In particular 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and emamectin benzoate in the ratio of 20: 1-1: in the weight ratio range of 20, ATI is far higher than TTI, which shows that the synergistic effect is obvious.

2) 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and emamectin benzoate in 80: 1-1: 80, the co-toxicity coefficient (CTC) is more than 80, and antagonism does not exist; 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and emamectin benzoate in the ratio of 40: 1-1: 20, the CTC is higher than 120, and the obvious synergistic effect is achieved; wherein, the ratio of 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine to emamectin benzoate is 40: 1-1: 20, the CTC is highest, the synergistic effect is strong, and particularly the weight ratio range is 4: 1, CTC reaches 193.00, and the synergistic effect is strongest.

3) 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and emamectin benzoate in the ratio of 1: 4-1: 20, the measured virulence index (ATI) is higher than the virulence index 432588.24 of emamectin benzoate.

4) 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and emamectin benzoate in 80: 1-1: 20, half Lethal Concentration (LC) to Chilo suppressalis as the proportion of emamectin benzoate increases₅₀) The reduction is obvious; 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and emamectin benzoate in the ratio of 1: 1-1: 80, LC of the compound composition of 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and emamectin benzoate₅₀Much lower than LC when 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine is used alone₅₀LC with emamectin benzoate alone₅₀Comparable or lower, 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and emamectin benzoate in the ratio 1: 4-1: 20 in the weight ratio range of the composition₅₀LC obviously lower than emamectin benzoate₅₀。

It can be seen that the present invention provides a composition of 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and emamectin benzoate, the ratio of 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine to emamectin benzoate being in the range of 80: 1-1: 80 in a weight ratio of no antagonism and a reduction in LC₅₀(ii) a 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and emamectin benzoate in the ratio of 40: 1-1: 20, 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and emamectin benzoate are mixed in a weight ratio of 40: 1-1: within the weight ratio range of 20, the synergistic effect is most obvious; 2-chloro-6- ((4-phenoxy)Phenylphenoxy) methyl) pyridine and emamectin benzoate in the ratio of 1: 4-1: 80 weight ratio of the composition₅₀Very low, the use safety is improved.

Combining the above factors, the weight ratio of 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine to emamectin benzoate is 8: 1-1: 20, the best effect is obtained.

Example 8

Mixing 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and emamectin benzoate according to the weight ratio of 80: 1-1: 80 to obtain a plurality of compositions, selecting the compositions corresponding to a plurality of specific weight ratios to determine the toxicity of the compositions to the rice leaf rollers, and the test results are shown in Table 8:

TABLE 8 comparison of virulence test results for rice leaf rollers

And (3) analyzing an experimental result: as can be seen from table 8:

1) 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and emamectin benzoate in 80: 1-1: within 80 weight percent, virulence indexes (ATI) were all found to be higher than the virulence index (TTI). In particular 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and emamectin benzoate in the ratio of 20: 1-1: within the weight proportion range of 80, ATI is far higher than TTI, which shows that the synergistic effect is obvious.

2) 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and emamectin benzoate in 80: 1-1: 80, the co-toxicity coefficient (CTC) is more than 80, and antagonism does not exist; 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and emamectin benzoate in the ratio of 40: 1-1: 80, the CTC is higher than 120, and the obvious synergistic effect is achieved; wherein, the ratio of 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine to emamectin benzoate is 20: 1-1: 8, the CTC is the highest, the synergistic effect is stronger, and particularly, the weight ratio range is 1: 1, the CTC reaches 170.20, and the synergistic effect is strongest.

3) 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and emamectin benzoate in the ratio of 1: 4-1: 80, the measured virulence indexes (ATI) are all higher than the virulence index 67533.33 of the emamectin benzoate.

4) 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and emamectin benzoate in 80: 1-1: 8, half Lethal Concentration (LC) to cnaphalocrocis medinalis with increasing emamectin benzoate ratio₅₀) The reduction is obvious; 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and emamectin benzoate in the ratio of 1: 1-1: 80, LC of the compound composition of 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and emamectin benzoate₅₀Much lower than LC when 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine is used alone₅₀LC with emamectin benzoate alone₅₀Comparable or lower, 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and emamectin benzoate in the ratio 1: 4-1: 80 weight ratio of the composition₅₀LC obviously lower than emamectin benzoate₅₀。

It can be seen that the present invention provides a composition of 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and emamectin benzoate, the ratio of 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine to emamectin benzoate being in the range of 80: 1-1: 80 in a weight ratio of no antagonism and a reduction in LC₅₀(ii) a 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and emamectin benzoate in the ratio of 40: 1-1: 20, 2-chloro-6- ((4-phenoxy) has synergistic effectPhenoxy) methyl) pyridine and emamectin benzoate in a ratio of 40: 1-1: 80, the synergistic effect is most obvious; 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and emamectin benzoate in the ratio of 1: 1-1: 80 weight ratio of the composition₅₀Very low, the use safety is improved.

Combining the above factors, the weight ratio of 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine to emamectin benzoate is 1: 1-1: in case 8, the best effect is obtained.

Example 9

Mixing 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and emamectin benzoate according to the weight ratio of 80: 1-1: 80 to obtain a plurality of compositions, selecting the compositions corresponding to a plurality of specific weight ratios to determine the toxicity of the compositions on the cabbage aphids, wherein the test results are shown in a table 9:

TABLE 9 comparison of virulence test results against aphids of Brassica oleracea

And (3) analyzing an experimental result: as can be seen from table 9:

1) 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and emamectin benzoate in the ratio of 40: 1-1: within 40 weight percent, virulence indexes (ATI) were all found to be higher than the virulence index (TTI). In particular 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and emamectin benzoate in the ratio of 4: 1-1: 40, ATI is much higher than TTI, which shows that the synergistic effect is obvious.

2) 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and emamectin benzoate in 80: 1-1: 80, the co-toxicity coefficient (CTC) is more than 80, and antagonism does not exist; 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and emamectin benzoate in the ratio of 40: 1-1: 40, the CTC is higher than 120, and the obvious synergistic effect is achieved; wherein, the ratio of 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine to emamectin benzoate is 20: 1-1: 40, the CTC is highest, the synergistic effect is strong, and particularly the weight ratio range is 4: 1, the CTC reaches 181.02, and the synergistic effect is strongest.

3) 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and emamectin benzoate in the ratio of 1: 4-1: 40, the measured virulence index (ATI) is higher than the virulence index 15423.08 of emamectin benzoate.

4) 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and emamectin benzoate in 80: 1-1: 8, half the Lethal Concentration (LC) to brevicoryne brassicae with increasing emamectin benzoate ratio₅₀) The reduction is obvious; 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and emamectin benzoate in the ratio of 1: 1-1: 80, LC of the compound composition of 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and emamectin benzoate₅₀Much lower than LC when 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine is used alone₅₀LC with emamectin benzoate alone₅₀Comparable or lower, 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and emamectin benzoate in the ratio 1: 4-1: 40 in weight ratio of the composition₅₀LC obviously lower than emamectin benzoate₅₀。

It can be seen that the present invention provides a composition of 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and emamectin benzoate, the ratio of 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine to emamectin benzoate being in the range of 80: 1-1: 80 in a weight ratio of no antagonism and a reduction in LC₅₀(ii) a 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and emamectin benzoate in the ratio of 40: 1-1: 40, 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and emamectin benzoate in20: 1-1: within the weight ratio range of 40, the synergistic effect is most obvious; 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and emamectin benzoate in the ratio of 1: 4-1: 40 in weight ratio of the composition₅₀Very low, the use safety is improved.

Combining the above factors, the weight ratio of 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine to emamectin benzoate is 1: 1-1: 40, the best effect is obtained.

Example 10

Mixing 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and emamectin benzoate according to the weight ratio of 80: 1-1: 80 to obtain a plurality of compositions, selecting the compositions corresponding to a plurality of specific weight ratios to determine the toxicity of the compositions to chilo suppressalis, and the test results are shown in table 10:

TABLE 10 comparison of virulence test results against Chilo suppressalis

And (3) analyzing an experimental result: as can be seen from table 10:

1) 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and emamectin benzoate in 80: 1-1: within a weight range of 20, virulence indexes (ATI) were all found to be higher than the virulence index (TTI). In particular 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and emamectin benzoate in the ratio of 40: 1-1: in the weight ratio range of 20, ATI is far higher than TTI, which shows that the synergistic effect is obvious.

2) 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and emamectin benzoate in 80: 1-1: 80, the co-toxicity coefficient (CTC) is more than 80, and antagonism does not exist; 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and emamectin benzoate in the ratio of 40: 1-1: 20, the CTC is higher than 120, and the obvious synergistic effect is achieved; wherein, the ratio of 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole to emamectin benzoate is 8: 1-1: 8, the CTC is the highest, the synergistic effect is stronger, and particularly, the weight ratio range is 4: 1, the CTC reaches 193.01, and the synergistic effect is strongest.

3) 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and emamectin benzoate in the ratio of 1: 4-1: 20, the measured virulence index (ATI) is higher than the virulence index 446823.53 of emamectin benzoate.

4) 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and emamectin benzoate in 80: 1-1: 20, half Lethal Concentration (LC) to Chilo suppressalis as the proportion of emamectin benzoate increases₅₀) The reduction is obvious; 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and emamectin benzoate in the ratio of 1: 1-1: 80, LC of the compound composition of 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and emamectin benzoate₅₀Much lower than LC when 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole is used alone₅₀LC with emamectin benzoate alone₅₀Comparable or lower, 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and emamectin benzoate in the ratio 1: 4-1: 20 in the weight ratio range of the composition₅₀LC obviously lower than emamectin benzoate₅₀。

It can be seen that the present invention provides a composition of 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and emamectin benzoate, the composition of 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and emamectin benzoate being in the range of 80: 1-1: 80 in a weight ratio of no antagonism and a reduction in LC₅₀(ii) a 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and emamectin benzoate in the ratio of 40: 1-1: 20, 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and emamectin benzoate are mixed in a weight ratio of 8: 1-1: within the weight ratio range of 8, the synergistic effect is most obvious;2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and emamectin benzoate in the ratio of 1: 1-1: 80 weight ratio of the composition₅₀Very low, the use safety is improved.

Combining the above factors, the weight ratio of 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole to emamectin benzoate was 4: 1-1: 20, the best effect is obtained.

Example 11

Mixing 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and emamectin benzoate according to the weight ratio of 80: 1-1: 80 to obtain a plurality of compositions, selecting the compositions corresponding to a plurality of specific weight ratios to determine the toxicity of the compositions to the rice leaf rollers, and the test results are shown in Table 11:

TABLE 11 comparison of virulence test results for rice leaf rollers

And (3) analyzing an experimental result: as can be seen from table 11:

1) 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and emamectin benzoate in 80: 1-1: within 80 weight percent, virulence indexes (ATI) were all found to be higher than the virulence index (TTI). In particular 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and emamectin benzoate in the ratio of 8: 1-1: within the weight proportion range of 80, ATI is far higher than TTI, which shows that the synergistic effect is obvious.

2) 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and emamectin benzoate in 80: 1-1: 80, the co-toxicity coefficient (CTC) is more than 80, and antagonism does not exist; 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and emamectin benzoate in the ratio of 20: 1-1: 80, the CTC is higher than 120, and the obvious synergistic effect is achieved; wherein, the ratio of 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole to emamectin benzoate is 20: 1-1: 4, the CTC is highest, the synergistic effect is stronger, and particularly, the weight ratio range is 4: 1, the CTC reaches 177.48, and the synergistic effect is strongest.

3) 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and emamectin benzoate in the ratio of 1: 4-1: 80, the measured virulence indexes (ATI) are all higher than the virulence index 65013.33 of the emamectin benzoate.

4) 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and emamectin benzoate in 80: 1-1: 20, half-Lethal Concentration (LC) to cnaphalocrocis medinalis with increasing emamectin benzoate ratio₅₀) The reduction is obvious; 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and emamectin benzoate in the ratio of 1: 1-1: 80, LC of the compound composition of 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and emamectin benzoate₅₀Much lower than LC when 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole is used alone₅₀LC with emamectin benzoate alone₅₀Comparable or lower, 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and emamectin benzoate in the ratio 1: 4-1: 80 weight ratio of the composition₅₀LC obviously lower than emamectin benzoate₅₀。

It can be seen that the present invention provides a composition of 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and emamectin benzoate, the composition of 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and emamectin benzoate being in the range of 80: 1-1: 80 in a weight ratio of no antagonism and a reduction in LC₅₀(ii) a 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and emamectin benzoate in the ratio of 20: 1-1: 80, 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and emamectin benzoate are mixed in a weight ratio of 20: 1-1: within the weight ratio range of 8, the synergistic effect is most obvious; 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and methylAmino abamectin benzoate in the ratio of 1: 1-1: 80 weight ratio of the composition₅₀Very low, the use safety is improved.

Combining the above factors, the weight ratio of 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole to emamectin benzoate was 4: 1-1: 80, the best effect is obtained.

Example 12

Mixing 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and emamectin benzoate according to the weight ratio of 80: 1-1: 80 to obtain a plurality of compositions, selecting the compositions corresponding to a plurality of specific weight ratios to determine the toxicity of the compositions on the cabbage aphids, wherein the test results are shown in a table 12:

TABLE 12 comparison of virulence test results against aphids of Brassica oleracea

And (3) analyzing an experimental result: as can be seen from table 12:

1) 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and emamectin benzoate in 80: 1-1: within 80 weight percent, virulence indexes (ATI) were all found to be higher than the virulence index (TTI). In particular 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and emamectin benzoate in the ratio of 8: 1-1: 40, ATI is much higher than TTI, which shows that the synergistic effect is obvious.

2) 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and emamectin benzoate in 80: 1-1: 80, the co-toxicity coefficient (CTC) is more than 80, and antagonism does not exist; 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and emamectin benzoate in the ratio of 40: 1-1: 40, the CTC is higher than 120, and the obvious synergistic effect is achieved; wherein, the ratio of 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole to emamectin benzoate is 20: 1-1: 20, the CTC is highest, the synergistic effect is strong, and particularly the weight ratio range is 8: 1, the CTC reaches 196.74, and the synergistic effect is strongest.

3) 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and emamectin benzoate in the ratio of 1: 4-1: 40, the measured virulence index (ATI) is higher than the virulence index 12915.38 of emamectin benzoate.

4) 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and emamectin benzoate in 80: 1-1: 8, half the Lethal Concentration (LC) to brevicoryne brassicae with increasing emamectin benzoate ratio₅₀) The reduction is obvious; 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and emamectin benzoate in the ratio of 1: 1-1: 80, LC of the compound composition of 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and emamectin benzoate₅₀Much lower than LC when 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole is used alone₅₀LC with emamectin benzoate alone₅₀Comparable or lower, 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and emamectin benzoate in the ratio 1: 4-1: 40 in weight ratio of the composition₅₀LC obviously lower than emamectin benzoate₅₀。

It can be seen that the present invention provides a composition of 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and emamectin benzoate, the composition of 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and emamectin benzoate being in the range of 80: 1-1: 80 in a weight ratio of no antagonism and a reduction in LC₅₀(ii) a 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and emamectin benzoate in the ratio of 40: 1-1: 40, 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and methylamino donkeyThe vitamin benzoate is prepared from 20: 1-1: within the weight ratio range of 20, the synergistic effect is most obvious; 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and emamectin benzoate in the ratio of 1: 1-1: 80 weight ratio of the composition₅₀Very low, the use safety is improved.

Combining the above factors, the weight ratio of 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole to emamectin benzoate was 8: 1-1: 40, the best effect is obtained.

In addition, specific dosage form examples are as follows:

example 13

Preparation of emulsifiable concentrate

An emulsifiable concentrate for the preparation of a composition having as active ingredients 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and spinetoram comprising:

adding 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and spinetoram into solvent oil No. 200, stirring to dissolve completely, adding calcium dodecyl benzene sulfonate and tristyryl polyoxyethylene ether, and stirring at high speed to form a uniform solution, thereby preparing the missible oil containing the 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and the spinetoram.

Example 14

Preparing aqueous emulsion

The aqueous emulsion of 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and spinetoram as active ingredients for preparing the composition comprises the following components:

mixing 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole, spinetoram, tristyryl polyoxyethylene ether phosphate and solvent oil No. 150 together to form a uniform oil phase; mixing soft water, ethylene glycol, glacial acetic acid, an organic silicon defoaming agent and xanthan gum to form a uniform water phase; stirring at a high speed in a reaction kettle, adding the oil phase into the water phase, slowly adding the carrier until the phase inversion point is reached, starting shearing, supplementing the carrier to 100 parts, and shearing for about half an hour to obtain the aqueous emulsion containing the 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and the spinetoram.

Example 15

Preparing microemulsion

A microemulsion of 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and spinetoram as active ingredients for preparing a composition comprising:

mixing 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole, spinetoram and No. 150 solvent oil together, stirring for dissolving, adding calcium dodecyl benzene sulfonate and an organic silicon defoamer, and stirring to form a uniform oil phase; mixing soft water, propylene glycol and glacial acetic acid to form a uniform water phase; stirring at high speed in a reaction kettle, adding the oil phase into the water phase to form a uniform and transparent solution, and thus obtaining the microemulsion containing the 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and the spinetoram.

Example 16

Formulating a microcapsule suspension

A microcapsule suspension comprising 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and spinetoram as active ingredients for preparing a composition, comprising:

dissolving 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and spinetoram in solvent oil No. 200, adding tristyryl polyoxyethylene polyoxypropylene ether, urea and formaldehyde, stirring uniformly, adjusting the pH value with glacial acetic acid to form a microcapsule oil phase, carrying out homogeneous shearing on a polycarboxylate dispersant, xanthan gum and soft water to obtain a water phase, and finally slowly adding the oil phase into the water phase under the condition of low-speed stirring to obtain the microcapsule suspending agent containing the 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and the spinetoram.

Example 17

Formulating aqueous suspensions

An aqueous suspension of 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and spinetoram as active ingredients in a preparation composition comprising:

mixing alkyl naphthalene sulfonic acid, ethylene glycol, xanthan gum, an organic silicon defoaming agent and soft water, shearing, adding 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and spinetoram, shearing, homogenizing for about 30 minutes, then passing through a sand mill, sanding for 1-2 hours until the particle size is less than 5 mu m, and thus obtaining the water suspending agent containing 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and spinetoram.

Example 18

Preparing soluble liquid

A soluble liquid formulation of 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and spinetoram as active ingredients for preparing a composition, comprising:

adding 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and spinetoram into dimethyl sulfoxide and pelargonamide, stirring uniformly, adding calcium dodecyl benzene sulfonate and cardanol polyoxyethylene ether, and stirring at high speed to form a uniform solution, thereby preparing the soluble liquid containing the 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and spinetoram.

Example 19

Preparing wettable powder

Wettable powder of 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and spinetoram as active ingredients for preparing the composition comprises the following components:

mixing 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole, spinetoram, a naphthalenesulfonate formaldehyde condensate, sodium dodecyl sulfate and kaolin together, stirring uniformly by a stirring kettle, crushing by an airflow crusher, and mixing uniformly to obtain the wettable powder containing the 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and the spinetoram.

Example 20

Preparing water dispersible granules

The water dispersible granule of the active ingredients of the preparation composition, namely 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and spinetoram, comprises the following components:

mixing 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole, spinetoram, polycarboxylate, sodium sulfonate, sodium chloride and filler, uniformly stirring by a stirring kettle, refining by an ultramicro airflow pulverizer, granulating by a fluidized bed, drying and screening to obtain the water dispersible granule containing the 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and the spinetoram.

Example 21

Compounding oil suspension

An oil suspension having as active ingredients 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and spinetoram, prepared from a composition comprising:

mixing 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole, spinetoram, castor oil polyoxyethylene ether, calcium dodecylbenzene sulfonate, oily carboxylate, organic bentonite and methyl oleate, shearing for about 30 minutes, and sanding for about 1 hour by a sanding machine to obtain the oil suspension containing the 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and the spinetoram.

Example 22

Preparation of emulsifiable concentrate

The missible oil containing the active ingredients of the composition, namely 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and emamectin benzoate, comprises the following components:

adding 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and emamectin benzoate into solvent oil No. 150 and cyclohexanone, stirring to dissolve completely, adding calcium dodecyl benzene sulfonate and oleic acid polyoxyethylene ether, and stirring at high speed to form a uniform solution, thereby preparing the missible oil containing the 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and the emamectin benzoate.

Example 23

Preparing aqueous emulsion

The aqueous emulsion of the active ingredients of the preparation composition, namely 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and emamectin benzoate, comprises the following components:

completely dissolving 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole, emamectin benzoate and BHT in pelargonamide, adding alkylphenol polyoxyethylene ether formaldehyde condensate sulfate and octylphenol polyoxyethylene ether, and stirring to form an oil phase; mixing soft water, ethylene glycol and xanthan gum to form a uniform water phase; stirring at a high speed in a reaction kettle, adding the oil phase into the water phase, slowly adding the carrier until the phase inversion point is reached, starting shearing, supplementing the carrier to 100 parts, and shearing for about half an hour to obtain the aqueous emulsion containing the 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and the emamectin benzoate.

Example 24

Preparing microemulsion

A microemulsion of 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and emamectin benzoate as active ingredients is prepared comprising:

mixing 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole, emamectin benzoate, alkylaryl ethoxylate, block polyether, calcium dodecylbenzene sulfonate, cyclohexanone and BHT together, and stirring to form a uniform oil phase; mixing soft water and glycerol to form a uniform water phase; stirring at high speed in a reaction kettle, adding the oil phase into the water phase to form a uniform and transparent solution, and thus obtaining the microemulsion containing the 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and the emamectin benzoate.

Example 25

Formulating a microcapsule suspension

The microcapsule suspending agent of which the effective components of the preparation composition are 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and emamectin benzoate comprises:

dissolving 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and emamectin benzoate in pelargonamide, adding alkylphenol phosphate, block polyether, TDI and ethylenediamine, stirring uniformly, adjusting the pH value with glacial acetic acid to form a microcapsule oil phase, homogenizing and shearing polycarboxylate, xanthan gum, glycol and soft water to obtain a water phase, and finally slowly adding the oil phase into the water phase under the condition of low-speed stirring to obtain the microcapsule suspending agent containing 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and emamectin benzoate.

Example 26

Formulating aqueous suspensions

An aqueous suspension of 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and emamectin benzoate as active ingredients for preparing a composition, comprising:

mixing benzene sulfonate, naphthalenesulfonate, a block copolymer, urea, xanthan gum, an organic silicon defoamer and soft water, adding 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and emamectin benzoate after shearing, then shearing and homogenizing for about 30 minutes, and sanding for 1-2 hours by a sand mill until the particle size is less than 5 mu m to obtain the water suspending agent containing the 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and the emamectin benzoate.

Example 27

Preparing soluble liquid

The soluble liquid agent of the active ingredients of the preparation composition, namely 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and emamectin benzoate, comprises the following components:

adding 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and emamectin benzoate into methanol and N-methyl pyrrolidone, uniformly stirring, adding calcium dodecyl benzene sulfonate and nonylphenol polyoxyethylene ether, and stirring at a high speed to form a uniform solution to obtain the soluble liquid containing the 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and the emamectin benzoate.

Example 28

Preparing wettable powder

The wettable powder for preparing the composition, the active ingredients of which are 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and emamectin benzoate, comprises the following components:

mixing 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole, emamectin benzoate, sodium lignosulfonate, nekal and diatomite together, stirring uniformly by a stirring kettle, crushing by an airflow crusher, and mixing uniformly to obtain the wettable powder containing the 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and the emamectin benzoate.

Example 29

Preparing water dispersible granules

The water dispersible granules of active ingredients of the preparation composition, namely 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and emamectin benzoate, comprise:

mixing 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole, emamectin benzoate, polycarboxylate, sodium dodecyl sulfate, NNO, ammonium sulfate and calcined kaolin together, uniformly stirring the mixture in a stirring kettle, refining the mixture by an ultramicro jet mill, extruding and granulating the refined mixture, drying and screening the granulated mixture to obtain the water dispersible granule containing the 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and the emamectin benzoate.

Example 30

Compounding oil suspension

An oil suspension agent of which the effective components of the preparation composition are 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and emamectin benzoate comprises:

mixing 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole, emamectin benzoate, castor oil polyoxyethylene ether, cardanol polyoxyethylene ether, calcium dodecylbenzene sulfonate, organic bentonite and methyl oleate, shearing for about 30 minutes, and sanding for about 1 hour by a sanding machine to obtain the oil suspension containing the 2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole and the emamectin benzoate.

Example 31

Preparation of emulsifiable concentrate

An emulsifiable concentrate of 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram as active ingredients for preparing a composition, comprising:

adding 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram into solvent oil No. 200, stirring to dissolve completely, adding calcium dodecyl benzene sulfonate and alkylaryl ethoxylate, and stirring at high speed to form a uniform solution, thereby preparing the missible oil containing the 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram.

Example 32

Preparing aqueous emulsion

The aqueous emulsion of 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram as active ingredients for preparing the composition comprises the following components:

dissolving 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram in pelargonamide by using a carrier, adding a block copolymer and tristyryl polyoxyethylene ether phosphate, and uniformly stirring to form an oil phase; mixing soft water, glycerol and xanthan gum to form a uniform water phase; stirring at a high speed in a reaction kettle, adding the oil phase into the water phase, slowly adding the carrier until the phase inversion point is reached, starting high shear, supplementing the carrier to 100 parts, and shearing for about half an hour to obtain the aqueous emulsion containing 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram.

Example 33

Preparing microemulsion

A microemulsion of 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram as active ingredients for preparing a composition comprising:

dissolving 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram in cyclohexanone, adding alkylaryl ethoxylate, oleic acid polyoxyethylene ether and sodium dodecyl benzene sulfonate, and uniformly stirring to form an oil phase; mixing soft water and glycerol to form a uniform water phase; stirring at high speed in a reaction kettle, adding the oil phase into the water phase to form a uniform and transparent solution, and thus obtaining the microemulsion containing the 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and the spinetoram.

Example 34

Formulating a microcapsule suspension

A microcapsule suspension having as active ingredients 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram, prepared as a composition, comprising:

dissolving 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram in xylene, adding a block copolymer, triphenylethylphenol polyoxyethylene ether, gelatin and gum, stirring uniformly, adjusting the pH value with glacial acetic acid to form a microcapsule oil phase, carrying out homogeneous shearing on polycarboxylate, propylene glycol, xanthan gum and soft water, then sanding the mixture by a sanding machine to obtain a water phase, and finally slowly adding the oil phase into the water phase under the condition of low-speed stirring to obtain the microcapsule suspending agent containing the 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram.

Example 35

Formulating aqueous suspensions

An aqueous suspension of 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram as active ingredients in a preparation composition comprising:

mixing triphenylethylphenol polyoxyethylene ether sulfate, benzene sulfonate, ethylene glycol, xanthan gum, an organic silicon defoaming agent and soft water, adding 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram after shearing, then shearing and homogenizing for about 30 minutes, and sanding for 1-2 hours by a sand mill until the particle size is less than 5 mu m to obtain the water suspending agent containing the 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram.

Example 36

Preparing soluble liquid

A soluble liquor comprising 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram as active ingredients for preparing a composition, comprising:

dissolving 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram in dimethyl sulfoxide and azomethidone, stirring uniformly, adding calcium dodecyl benzene sulfonate and alkylaryl ethoxylate, and stirring at high speed to form a uniform solution, thus obtaining the soluble liquid containing 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram.

Example 37

Preparing wettable powder

Wettable powder of 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram as active ingredients for preparing the composition comprises the following components:

mixing 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine, spinetoram, NNO, sodium dodecyl sulfate and light calcium carbonate together, stirring uniformly by a stirring kettle, crushing by an airflow crusher, and mixing uniformly to obtain the wettable powder containing the 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and the spinetoram.

Example 38

Preparing water dispersible granules

Water dispersible granules of 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram as active ingredients for preparing a composition comprising:

mixing 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine, spinetoram, polycarboxylate, 1004, alkylphenol formaldehyde condensate, monopotassium phosphate and corn starch, uniformly stirring the mixture in a stirring kettle, refining the mixture by an ultramicro jet mill, kneading the refined mixture, granulating the kneaded mixture by a fluidized bed, drying and screening the granulated mixture to obtain the water dispersible granule containing the 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram.

Example 39

Compounding oil suspension

An oil suspension having as active ingredients 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and spinetoram, prepared from a composition comprising:

mixing 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine, spinetoram, castor oil polyoxyethylene ether, calcium dodecylbenzene sulfonate, tristyrylphenol polyoxyethylene ether, organic bentonite and methyl oleate, shearing for 30 ℃, and sanding by a sanding machine to obtain the oil suspension containing the 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and the spinetoram.

Example 40

Preparation of emulsifiable concentrate

The missible oil with the effective components of 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and emamectin benzoate for preparing the composition comprises the following components:

adding 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and emamectin benzoate into solvent oil No. 150, stirring to dissolve completely, adding calcium dodecyl benzene sulfonate and cardanol polyoxyethylene ether, and stirring to form a uniform solution to obtain the missible oil containing the 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and the emamectin benzoate.

EXAMPLE 41

Preparing aqueous emulsion

The aqueous emulsion of 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and emamectin benzoate as active ingredients for preparing the composition comprises the following components:

dissolving 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and emamectin benzoate in pelargonamide by using a carrier, adding tristyryl polyoxyethylene ether phosphate and a block copolymer, and stirring to form an oil phase; mixing soft water, ethylene glycol and xanthan gum to form a uniform water phase; stirring at high speed in a reaction kettle, adding the oil phase into the water phase until the phase inversion point, starting high-speed shearing, and supplementing the carrier to 100 parts to obtain the aqueous emulsion containing 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and emamectin benzoate.

Example 42

Preparing microemulsion

A microemulsion of 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and emamectin benzoate as active ingredients is prepared comprising:

mixing 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine, emamectin benzoate, BHT, calcium dodecylbenzene sulfonate and alkyl aryl ethoxylate together, and stirring to form a uniform oil phase; mixing soft water and ethylene glycol to form a uniform water phase; stirring at high speed in a reaction kettle, adding the oil phase into the water phase to form a uniform and transparent solution, and thus obtaining the microemulsion containing the 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and the emamectin benzoate.

Example 43

Formulating a microcapsule suspension

A microcapsule suspending agent containing 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and emamectin benzoate as effective components for preparing the composition comprises:

dissolving 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and emamectin benzoate in methyl caprylate, adding block polyether, alkylphenol phosphate, MDI (diphenylmethane diisocyanate) and ethylenediamine, uniformly stirring, adjusting the pH value with hydrochloric acid to form a microcapsule oil phase, carrying out uniform shearing on polycarboxylate, xanthan gum, glycol and a soft water body to obtain a water phase, and finally slowly adding the oil phase into the water phase under the condition of low-speed stirring to obtain the microcapsule suspending agent containing 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and emamectin benzoate.

Example 44

Formulating aqueous suspensions

An aqueous suspension of 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and emamectin benzoate as active ingredients for the preparation of a composition comprising:

mixing polycarboxylate, alkylbenzene sulfonate, block polyether, glycerol, xanthan gum, an organic silicon defoamer and soft water, shearing, adding 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and emamectin benzoate, shearing, homogenizing for about 30 minutes, and sanding for 1-2 hours by a sand mill until the particle size is less than 5 mu m to obtain the water suspending agent containing the 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and the emamectin benzoate.

Example 45

Preparing soluble liquid

The soluble liquid agent of the active ingredients of the preparation composition, namely 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and emamectin benzoate, comprises the following components:

adding 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and emamectin benzoate into dimethyl sulfoxide and N-methyl pyrrolidone, uniformly stirring, adding calcium dodecyl benzene sulfonate and alkylphenol block polyether, and stirring at high speed to form a uniform solution, thereby preparing the soluble liquid containing the 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and the emamectin benzoate.

Example 46

Preparing wettable powder

The wettable powder for preparing the composition, the active ingredients of which are 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and emamectin benzoate, comprises the following components:

mixing 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine, emamectin benzoate, alkylphenol naphthalenesulfonate formaldehyde polymer, sodium dodecyl benzene sulfonate, NNO and kaolin together, stirring uniformly by a stirring kettle, crushing by an airflow crusher, and mixing uniformly to obtain the wettable powder containing the 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and the emamectin benzoate.

Example 47

Preparing water dispersible granules

The water dispersible granule of active ingredients of the preparation composition, namely 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and emamectin benzoate, comprises:

uniformly mixing 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine, emamectin benzoate, polycarboxylate, sodium dodecyl sulfate, calcium lignosulfonate, anhydrous sodium sulfate and corn starch, crushing by using an ultramicro jet mill, granulating by using a fluidized bed, drying and screening to obtain the water dispersible granule containing the 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and the emamectin benzoate.

Example 48

Compounding oil suspension

An oil suspension comprising 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and emamectin benzoate as active ingredients for preparing the composition comprises:

uniformly mixing 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine, emamectin benzoate, alkylphenol polyoxyethylene ether phosphate, cardanol polyoxyethylene ether, oleic acid polyoxyethylene ether, organic bentonite and fatty acid methyl ester, shearing for about 30 minutes, and sanding for about 1 hour by a sanding machine to obtain the oil suspension containing the 2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine and the emamectin benzoate.

Example 49

Test of field drug effect

The inventors also conducted the respective drug efficacy tests, and the test results are shown in the following table:

TABLE 13 control of vegetable thrips

TABLE 14 control of cabbage moth

TABLE 15 control of cabbage beet armyworm

TABLE 16 control of cucumber whitefly (7 days apart, observation of control after the second application)

In conclusion, the pesticide composition obtained by compounding the component A (2-chloro-6- ((4-phenoxyphenoxy) methyl) pyridine/2-chloro-5- ((4-phenoxyphenoxy) methyl) thiazole) and the component B (spinetoram/emamectin benzoate) has the pesticide effect obviously higher than the control effect when a single-dose product is used, and has excellent persistence, so that the pesticide effect can be achieved by using a small dose, and the pesticide resistance risk of pests can be greatly reduced.

While the invention has been described with reference to a preferred embodiment, it will be understood by those skilled in the art that various changes in form and detail may be made therein without departing from the spirit and scope of the invention.

Claims

1. An insecticidal composition comprising: a component A and a component B;

and the weight ratio of the A component to the B component is 80: 1-1: 80.

2. an insecticidal composition according to claim 1 further comprising an adjuvant and/or a carrier.

3. The insecticidal composition according to claim 2, wherein the auxiliary agent is selected from any one or a combination of several of an emulsifier, a dispersant, an antifreeze, a cosolvent, a thickener, an antifoaming agent, a stabilizer, a wetting agent, a filler, a capsule wall material, a pH regulator and a disintegrant.

4. The insecticidal composition according to claim 2, wherein said carrier is selected from the group consisting of xylene, toluene, diesel oil, methanol, ethanol, n-butanol, isopropanol, mineral spirit 150#, mineral spirit 200#, dimethylformamide, dimethyl sulfoxide, methyl oleate, soybean oil, epoxidized soybean oil, corn oil, rapeseed oil, cottonseed oil, turpentine, white oil, kerosene, and water.

5. The insecticidal composition according to claim 1, wherein the formulation of the insecticidal composition is selected from any one of emulsifiable concentrate, aqueous emulsion, microemulsion, microcapsule suspension, aqueous suspension, soluble liquid, wettable powder, water dispersible granule and oil suspension.

6. Use of the pesticidal composition of any one of claims 1 to 5 for controlling pests.

7. The use of the pesticidal composition according to claim 6 for controlling pests, wherein the pests are any one of thrips, armyworm, beet armyworm, striped rice borer, rice leaf roller, cabbage aphid.