CN112220840A - Formula of acer truncatum and spina date seed soft capsules - Google Patents

Formula of acer truncatum and spina date seed soft capsules Download PDF

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Publication number
CN112220840A
CN112220840A CN202011251797.4A CN202011251797A CN112220840A CN 112220840 A CN112220840 A CN 112220840A CN 202011251797 A CN202011251797 A CN 202011251797A CN 112220840 A CN112220840 A CN 112220840A
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formula
capsule
acer truncatum
spina date
date seed
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雷国平
姚德中
龚耀平
申膑
杨伟玲
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Wuhan Linbaolai Biotechnology Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/20—Aceraceae (Maple family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4415—Pyridoxine, i.e. Vitamin B6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/55—Linaceae (Flax family), e.g. Linum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725—Ziziphus, e.g. jujube
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

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  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Pain & Pain Management (AREA)
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Abstract

The invention discloses a formula of a acer truncatum and spina date seed soft capsule, which is prepared from the following raw materials in parts by weight: 170mg of acer truncatum buge oil 150-70 mg, 50-70mg of phosphatidylserine, 20-40mg of soybean lecithin, 20-40mg of linseed oil, 40-60mg of spina date seed extract, 5-15mg of curcumin, 65-15 μmg of vitamin B and 5-15mg of compound mineral substances, edible gelatin can be selected as an adhesive in the formula to improve the adhesive strength of the capsule, glycerol can be selected as an auxiliary plasticizer in the formula to improve the plasticity and the forming speed of the capsule, polyethylene glycol can be selected as a cosolvent in the formula to improve the mixing degree of the raw materials of the capsule, the acer truncatum buge oil and the spina date seed are adopted as the raw materials to prepare the soft capsule, the soft capsule can achieve the effects of protecting the brain, supplementing nervonic acid and improving the memory after being taken by a human body, and can relieve the brain and nerve fatigue of modern people, simultaneously, the effects of nourishing liver, calming heart and soothing the nerves are achieved.

Description

Formula of acer truncatum and spina date seed soft capsules
Technical Field
The invention relates to the field of capsule formulas, in particular to a formula of a acer truncatum bunge and spina date seed soft capsule.
Background
Modern society's life rhythm is fast, and the competition is violent, and pressure is big, and various bad habits and customs, human sub-health state is more and more serious, and brain and nervous system are in tension and tired for a long time.
The acer truncatum buge oil can extract nervonic acid, can repair and dredge the damaged nervous system of a human body, promote the regeneration of nerve cells and delay the aging of the human body, is an 'advanced nutrient' necessary for the growth, regeneration and maintenance of the nerve cells, particularly brain cells and the like, and is a carrier substance which can penetrate through a horny layer and quickly bring water-soluble vitamins into a corium layer; the spina date seed is a traditional Chinese medicine material, has the effects of nourishing the liver, calming the heart, calming the nerves and arresting sweating, and can treat dysphoria, insomnia, palpitation, severe palpitation, polydipsia and sweating due to deficiency; soybean extract: PS phosphatidylserine, also known as complex nervonic acid, is extracted from natural soybean oil mill residues, is an active substance of cell membranes, and is particularly present in brain cells. The functions of the medicine are mainly to improve the function of nerve cells, regulate the conduction of nerve pulses and enhance the memory function of the brain, and the medicine can quickly enter the brain through a blood brain barrier after being absorbed due to strong lipophilicity, thereby playing the roles of relieving blood vessel smooth muscle cells and increasing the blood supply of the brain; soybean lecithin: the product essential for neural development is used together with PS phosphatidylserine.
The modern society has fast pace of life, fierce competition and great pressure, and various bad living habits, the sub-health state of the human body is increasingly serious, and the brain and the nervous system are in a state of tension and fatigue for a long time, which has certain influence on life and work, so the prescription of the acer truncatum bunge and spina date seed soft capsule needs to be provided.
Disclosure of Invention
The invention aims to provide a prescription of a acer truncatum and spina date seed soft capsule, which aims to solve the problems in the background technology.
In order to achieve the purpose, the invention provides the following technical scheme: the prescription of the acer truncatum and spina date seed soft capsule is prepared from the following raw materials in parts by weight: 150-170mg of acer truncatum oil, 50-70mg of phosphatidylserine, 20-40mg of soybean lecithin, 20-40mg of linseed oil, 40-60mg of spina date seed extract, 5-15mg of curcumin, 65-15 mu mg of vitamin B and 5-15mg of compound mineral.
Preferably, the formula proportion 1 of the capsule is as follows:
raw materials Specification of Content mg/granule
Acer truncatum oil The nervonic acid content is 5% 150
Phosphatidylserine 60％ 50
Soybean lecithin 99％ 20
Linseed oil Linolenic acid 57 percent 20
Wild jujube seed extract 2 percent of jujuboside 40
Curcumin (curcumin) 95％ 5
Vitamin B6 5ug
Composite mineral 5
Preferably, the formula ratio 2 of the capsule is as follows:
raw materials Specification of Content mg/granule
Acer truncatum oil The nervonic acid content is 5% 160
Phosphatidylserine 60％ 60
Soybean lecithin 99％ 30
Linseed oil Linolenic acid 57 percent 30
Wild jujube seed extract 2 percent of jujuboside 50
Curcumin (curcumin) 95％ 10
Vitamin B6 10ug
Composite mineral 10
Preferably, the formula ratio 3 of the capsule is as follows:
Figure BDA0002771819960000021
Figure BDA0002771819960000031
preferably, edible gelatin is used as the binder in the formulation to improve the binding strength of the capsule.
Preferably, glycerol is optionally used as an adjuvant plasticizer in the formulation to enhance the plasticity and forming speed of the capsule.
Preferably, polyethylene glycol is optionally used as a cosolvent in the formulation to enhance the mixing of the capsule ingredients.
Preferably, the preparation process flow of the capsule is as follows:
s1: weighing: weighing acer truncatum oil, phosphatidylserine, soybean lecithin, linseed oil, spina date seed extract, curcumin, vitamin B6 and compound mineral according to the mass parts in the formula proportion;
s2: mixing: putting the weighed acer truncatum buge oil, phosphatidylserine, soybean lecithin, linseed oil, spina date seed extract, curcumin, vitamin B6 and compound mineral substance into a drying total mixer subjected to steam sterilization at 100 ℃ for 1 hour, covering a mixer cover, mixing for 50-70 minutes, and keeping the temperature between 38 ℃ and 45 ℃ to obtain a mixture;
s3: homogenizing and emulsifying: putting the mixture obtained in the step S2 into an emulsification tank, and uniformly stirring and emulsifying to obtain a glue solution;
s4: degassing: degassing the glue solution in a vacuum tank at 60 ℃, and measuring the viscosity, fluidity, moisture and color of the glue solution;
s5, glue melting: putting the glue solution into a high-temperature glue dissolving tank for dissolving glue;
s6, filling and preparing capsules: and filling the obtained content into capsule shells, and sealing and packaging.
The invention has the technical effects and advantages that: the invention relates to a formula of a acer truncatum and spina date seed soft capsule, which is prepared by adopting acer truncatum oil and spina date seeds as raw materials, can achieve the effects of protecting the brain, supplementing nervonic acid, improving the memory after being taken by a human body, relieve the fatigue of the brain and the nerves of modern people, and simultaneously achieve the effects of nourishing the liver, calming the heart and soothing the nerves;
through adding the phosphatidylserine soybean lecithin into the capsule formula, the phosphatidylserine soybean lecithin and the capsule formula can be used in a matching way to improve the function of nerve cells, regulate the conduction of nerve pulses and enhance the memory function of the brain, and because the phosphatidylserine soybean lecithin has strong lipophilicity, the phosphatidylserine soybean lecithin can quickly enter the brain through a blood brain barrier after being absorbed, thereby playing the roles of relieving blood vessel smooth muscle cells and increasing the blood supply of the brain;
by adding the linseed oil into the capsule formula, the linseed oil contains rich linolenic acid (the content of the linolenic acid can reach 57 percent), can be oxidized into DHA (docosahexaenoic acid) which governs brain running in vivo, and provides sufficient nutrition for the brain; curcumin (content 95%) is added into the capsule formula to achieve anti-inflammatory and antioxidant effects; by adding vitamin B6, synthesis and metabolism of neurotransmitter can be effectively regulated; by adding compound mineral, it can achieve antidepressant effect and relieve disordered brain.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The invention provides a formula of a acer truncatum and spina date seed soft capsule, which is prepared from the following raw materials in parts by weight: 150-170mg of acer truncatum oil, 50-70mg of phosphatidylserine, 20-40mg of soybean lecithin, 20-40mg of linseed oil, 40-60mg of spina date seed extract, 5-15mg of curcumin, 65-15 mu mg of vitamin B and 5-15mg of compound mineral.
A prescription of a soft capsule of acer truncatum and spina date seeds is disclosed, the prescription proportion of the capsule is 1:
Figure BDA0002771819960000041
Figure BDA0002771819960000051
a prescription of a soft capsule of acer truncatum and spina date seeds, the prescription proportion 2 of the capsule is as follows:
raw materials Specification of Content mg/granule
Acer truncatum oil The nervonic acid content is 5% 160
Phosphatidylserine 60％ 60
Soybean lecithin 99％ 30
Linseed oil Linolenic acid 57 percent 30
Wild jujube seed extract 2 percent of jujuboside 50
Curcumin (curcumin) 95％ 10
Vitamin B6 10ug
Composite mineral 10
A prescription of a soft capsule of acer truncatum and spina date seeds is disclosed, the prescription proportion of the capsule is 3:
raw materials Specification of Content mg/granule
Acer truncatum oil The nervonic acid content is 5% 170
Phosphatidylserine 60％ 70
Soybean lecithin 99％ 40
Linseed oil Linolenic acid 57 percent 40
Wild jujube seed extract 2 percent of jujuboside 60
Curcumin (curcumin) 95％ 15
Vitamin B6 15ug
Composite mineral 15
A formulation of a soft capsule containing Acer Truncatum Bunge and semen Ziziphi Spinosae can be prepared by using edible gelatin as binder to improve the bonding strength of the capsule.
A formulation of a soft capsule containing Acer Truncatum Bunge and semen Ziziphi Spinosae can be prepared by using glycerol as plasticizer as adjuvant for improving plasticity and forming speed of the capsule.
A formulation of a soft capsule containing Acer Truncatum Bunge and semen Ziziphi Spinosae can be selected from polyethylene glycol as cosolvent for improving mixing degree of raw materials of the capsule.
The prescription of the acer truncatum and spina date seed soft capsule is characterized in that the preparation process flow of the capsule is as follows:
s1: weighing: weighing acer truncatum oil, phosphatidylserine, soybean lecithin, linseed oil, spina date seed extract, curcumin, vitamin B6 and compound mineral according to the mass parts in the formula proportion;
s2: mixing: putting the weighed acer truncatum buge oil, phosphatidylserine, soybean lecithin, linseed oil, spina date seed extract, curcumin, vitamin B6 and compound mineral substance into a drying total mixer subjected to steam sterilization at 100 ℃ for 1 hour, covering a mixer cover, mixing for 50-70 minutes, and keeping the temperature between 38 ℃ and 45 ℃ to obtain a mixture;
s3: homogenizing and emulsifying: putting the mixture obtained in the step S2 into an emulsification tank, and uniformly stirring and emulsifying to obtain a glue solution;
s4: degassing: degassing the glue solution in a vacuum tank at 60 ℃, and measuring the viscosity, fluidity, moisture and color of the glue solution;
s5, glue melting: putting the glue solution into a high-temperature glue dissolving tank for dissolving glue;
s6, filling and preparing capsules: and filling the obtained content into capsule shells, and sealing and packaging.
Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that modifications may be made to the embodiments or portions thereof without departing from the spirit and scope of the invention.
The standard raw materials used by the invention can be purchased from the market, and the special-shaped pieces can be customized according to the description of the specification.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims (8)

1. The formula of the acer truncatum and spina date seed soft capsule is characterized by being prepared from the following raw materials in parts by weight: 150-170mg of acer truncatum oil, 50-70mg of phosphatidylserine, 20-40mg of soybean lecithin, 20-40mg of linseed oil, 40-60mg of spina date seed extract, 5-15mg of curcumin, 65-15 mu mg of vitamin B and 5-15mg of compound mineral.
2. The formula of the acer truncatum and spina date seed soft capsule as claimed in claim 1, wherein the formula proportion of the capsule is 1:
raw materials Specification of Content mg/granule Acer truncatum oil The nervonic acid content is 5% 150 Phosphatidylserine 60％ 50 Soybean lecithin 99％ 20 Linseed oil Linolenic acid 57 percent 20 Wild jujube seed extract 2 percent of jujuboside 40 Curcumin (curcumin) 95％ 5 Vitamin B6 5ug Composite mineral 5
3. The formula of the acer truncatum and spina date seed soft capsule as claimed in claim 1, wherein the formula proportion 2 of the capsule is as follows:
raw materials Specification of Content mg/granule Acer truncatum oil The nervonic acid content is 5% 160 Phosphatidylserine 60％ 60 Soybean lecithin 99％ 30 Linseed oil Linolenic acid 57 percent 30 Wild jujube seed extract 2 percent of jujuboside 50 Curcumin (curcumin) 95％ 10 Vitamin B6 10ug Composite mineral 10
4. The formula of the acer truncatum and spina date seed soft capsule as claimed in claim 1, wherein the formula proportion of the capsule is 3:
Figure FDA0002771819950000011
Figure FDA0002771819950000021
5. the formula of the acer truncatum and spina date seed soft capsule as claimed in claim 1, wherein edible gelatin can be used as a binder in the formula for improving the bonding strength of the capsule.
6. The formulation of claim 1, wherein glycerol is used as an adjuvant plasticizer in the formulation to improve the plasticity and forming speed of the capsule.
7. The formula of the acer truncatum and spina date seed soft capsule as claimed in claim 1, wherein polyethylene glycol can be used as a cosolvent in the formula for improving the mixing degree of the raw materials of the capsule.
8. The formula of the acer truncatum and spina date seed soft capsule as claimed in claim 1, wherein the preparation process flow of the capsule is as follows:
s1: weighing: weighing acer truncatum oil, phosphatidylserine, soybean lecithin, linseed oil, spina date seed extract, curcumin, vitamin B6 and compound mineral according to the mass parts in the formula proportion;
s2: mixing: putting the weighed acer truncatum buge oil, phosphatidylserine, soybean lecithin, linseed oil, spina date seed extract, curcumin, vitamin B6 and compound mineral substance into a drying total mixer subjected to steam sterilization at 100 ℃ for 1 hour, covering a mixer cover, mixing for 50-70 minutes, and keeping the temperature between 38 ℃ and 45 ℃ to obtain a mixture;
s3: homogenizing and emulsifying: putting the mixture obtained in the step S2 into an emulsification tank, and uniformly stirring and emulsifying to obtain a glue solution;
s4: degassing: degassing the glue solution in a vacuum tank at 60 ℃, and measuring the viscosity, fluidity, moisture and color of the glue solution;
s5, glue melting: putting the glue solution into a high-temperature glue dissolving tank for dissolving glue;
s6, filling and preparing capsules: and filling the obtained content into capsule shells, and sealing and packaging.
CN202011251797.4A 2020-11-11 2020-11-11 Formula of acer truncatum and spina date seed soft capsules Pending CN112220840A (en)

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105311072A (en) * 2015-08-25 2016-02-10 北京世纪合辉医药科技股份有限公司 Healthcare product capable of improving memory and production method thereof
CN105853527A (en) * 2016-05-24 2016-08-17 广州元宝枫生物科技有限公司 Acer truncatum bunge-containing traditional Chinese medicine composition with sleep improving function and application thereof
CN108142950A (en) * 2017-12-27 2018-06-12 浙江健智元生物科技有限公司 A kind of acer truncatum seed oil composite Nano microcapsule powder for improving brain neuroblastoma and preparation method thereof
CN111418666A (en) * 2020-05-06 2020-07-17 内蒙古宝枫科技开发有限公司 Method for preparing acer truncatum seed oil and linseed oil mixed nutrition enhanced oil
CN111955737A (en) * 2020-05-25 2020-11-20 河南磐康健康管理股份有限公司 Composition for preventing and regulating cranial nerve related diseases, food and application thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105311072A (en) * 2015-08-25 2016-02-10 北京世纪合辉医药科技股份有限公司 Healthcare product capable of improving memory and production method thereof
CN105853527A (en) * 2016-05-24 2016-08-17 广州元宝枫生物科技有限公司 Acer truncatum bunge-containing traditional Chinese medicine composition with sleep improving function and application thereof
CN108142950A (en) * 2017-12-27 2018-06-12 浙江健智元生物科技有限公司 A kind of acer truncatum seed oil composite Nano microcapsule powder for improving brain neuroblastoma and preparation method thereof
CN111418666A (en) * 2020-05-06 2020-07-17 内蒙古宝枫科技开发有限公司 Method for preparing acer truncatum seed oil and linseed oil mixed nutrition enhanced oil
CN111955737A (en) * 2020-05-25 2020-11-20 河南磐康健康管理股份有限公司 Composition for preventing and regulating cranial nerve related diseases, food and application thereof

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Application publication date: 20210115