CN112220804A

CN112220804A - Externally applied medicine for skin

Info

Publication number: CN112220804A
Application number: CN202011130722.0A
Authority: CN
Inventors: 罗张龙; 王永进; 宋华相
Original assignee: WUHAN JIANMIN DAPENG PHARMACEUTICAL CO Ltd
Current assignee: WUHAN JIANMIN DAPENG PHARMACEUTICAL CO Ltd
Priority date: 2020-10-21
Filing date: 2020-10-21
Publication date: 2021-01-15

Abstract

The invention provides an externally applied medicine for skin, which comprises the components of in-vitro cultured bezoar powder. The preparation method comprises the following steps: in vitro cultured calculus bovis is subjected to superfine grinding into 600-mesh fine powder to obtain the calculus bovis powder. The external skin medicament is prepared by cultivating bezoar in vitro, taking the bezoar with the effects of clearing heat and removing toxicity and enhancing the transdermal absorption effect of the medicament, promoting tissue regeneration of a sore without leaving scars, and has special effects of simple and special medicament, is mainly externally used for treating various wound healing and repairing, including but not limited to bedsores, herpes zoster, various sores and ulcers and other skin diseases, and is used for promoting tissue regeneration and healing sores. Can also be used for treating skin wound and wound bleeding, disunion of wound, tissue ulceration and necrosis, infection and suppuration, etc. caused by operation. The invention has simple components and good curative effect, can be directly externally applied to skin, is easier to be absorbed, and has better healing and repairing effects on wound surfaces.

Description

Externally applied medicine for skin

Technical Field

The invention belongs to the technical field of medicines, and particularly relates to an externally applied medicine for skin.

Background

The natural bezoar is gallstone of cattle, is obtained occasionally by depending on cattle slaughtering and is only produced in cattle, the natural incidence rate of the cattle gallstone disease is about 2-3 per mill, and the output of the natural bezoar in China is only about 700kg at most according to the stock-keeping number of cattle in China and the natural incidence rate of the cattle gallstone disease estimated by expert research. The global natural bezoar production is about 3000kg, and only 1/3 of them enters mainland china, and the rest flows into japan, korea, taiwan, etc. Therefore, folk medicine has the saying that calculus bovis is difficult to be obtained because of the availability of gold.

Because the natural bezoar has low yield and large market demand, the bezoar used in China depends on import for a long time and has very high price. In order to avoid the spread of bovine spongiform encephalopathy once in europe, north america and australia at the end of the 20 th century, the national food and drug administration specially issues a document to forbid the import of bovine-derived products, so that the contradiction between supply and demand of natural bezoar is further aggravated, a large amount of smuggling bezoar is caused to fill the market, and serious hidden dangers and threats are brought to the public drug safety.

For a long time, Chinese and foreign medical experts have diligently researched natural bezoar, and the modern medical and pharmaceutical technology is expected to be applied to find a substitute of the natural bezoar. In 1972 and 1989, the national approval of artificial bezoar and cultivated bezoar was provided successively.

1. The artificial bezoar is prepared by simply and physically mixing cow bile powder, cholic acid, hyodeoxycholic acid, taurine, bilirubin and the like. Has obvious difference with the natural bezoar in the aspects of components, physical structure, drug effect and the like, and the content of bilirubin which is the main effective component of the bezoar is only 0.7 percent which is far lower than the standard that the content of natural bezoar is not lower than 35 percent. In addition, some of the Chinese patent medicines using artificial bezoar also have side effects such as dizziness, postural hypotension, nausea, vomiting, dry mouth, rash, etc. which are not possessed by natural bezoar. Therefore, the southeast Asia countries such as Japan have no instruction to take the medicine of the artificial bezoar powder in mouth.

2. The cultivated bezoar is gallstone cultivated by implanting sclerotium into living gallbladder of cattle through surgical operation, and is taken out with core during operation or slaughter. The health department of 2 months in 1990 clearly stipulates that the bilirubin content in cultured bezoar is more than 35% (containing 35%) and can be used as same as that of natural bezoar, the bilirubin content is 18% -35% and can only be used for non-first-aid patent medicine formula, and the bilirubin content is below 18% and can not be used for medicine, in the Wei medicine character [90] No. 9 'Notification about temporary management method of cultured bezoar'. In the seventh and eighty years of the last century, more than 10 manufacturers have produced cultivated bezoar due to high bezoar price and low beef price, but no production permit document and manufacturer have produced cultivated bezoar due to high production cost.

Because the artificial bezoar has poor curative effect and the cultivated bezoar is not produced by people, the two substitutes of the natural bezoar do not really relieve the contradiction of the lack of natural bezoar resources.

The in vitro cultured bezoar is developed by scientific research team of famous medical experts such as Cuofan court ancestor academy and professor Chua Hongjiao in China for thirty years, and is prepared by applying modern biotechnology of high technology, destroying the colloidal balance of ox bile by the action of biological enzyme generated by bacterial fermentation, and simulating the generation mechanism of natural bezoar, and has the same properties, structure, components, content, medicinal effect and clinical curative effect as natural bezoar. Because the natural bezoar has various sources, large individual difference, some microbial parasitic bacteria and other factors, the bezoar cultivated in vitro is better than the natural bezoar in the aspects of stability of main components and medication safety. The in vitro cultured calculus bovis technology realizes the industrialized production of calculus bovis, has short period, low cost and controllable components, and the in vitro cultured calculus bovis can be used as the natural calculus bovis according to the specific prescription of the national food and drug administration.

The problem that the wound surface is not easy to heal and repair after being damaged often occurs in daily life and clinic, for example, the bleeding of the skin wound surface and the wound of a patient caused by bedsore, herpes zoster or pyocutaneous disease, operation and the like is not continuous, the wound is not healed, tissue ulceration and necrosis or infection and suppuration and the like, and the prior external medicine for skin containing bezoar components has complex components and complex preparation method. Aiming at the problem, the invention provides an externally applied skin medicament which has simple components and a simple preparation method, but has good effect.

Disclosure of Invention

The invention provides a skin external medicament, which aims to solve the problems of continuous bleeding, no healing after breakage, tissue ulceration and necrosis, infection and suppuration and the like of skin wounds and wounds caused by bedsores, herpes zoster or pyocutaneous disease, operation and the like and enable the wounds to heal and repair as soon as possible.

An external preparation for skin is prepared from in vitro cultured calculus bovis powder.

A method for preparing skin external preparation comprises micronizing in vitro cultured calculus bovis into 600 mesh fine powder.

A topical skin preparation is used for healing wound.

The skin external preparation is used for treating bedsore, herpes zoster or pyocutaneous disease.

The skin external application is used for treating ceaseless bleeding, disunion of damaged skin and wound, tissue ulceration and necrosis or infection and suppuration of skin wound and wound caused by operation.

The invention has the beneficial effects that: the composition has simple components and good curative effect, can be directly externally applied to skin, is easier to absorb, and has better healing and repairing effects on wound surfaces.

Drawings

Fig. 1(a) is a picture of an abraded wound surface before a patient uses a skin external preparation of the present invention; fig. 1 (B) is a wound surface picture of a patient after using a skin external preparation of the present invention for 3 days; fig. 1(C) is a wound surface picture of a patient 7 days after the patient uses the externally applied skin drug of the present invention.

Detailed Description

Example 1

An external preparation for skin is prepared from in vitro cultured calculus bovis powder. Fig. 1(a) is a picture of an abraded wound surface before a patient uses a skin external preparation of the present invention; fig. 1 (B) is a wound surface picture of a patient after using a skin external preparation of the present invention for 3 days; fig. 1(C) is a wound surface picture of a patient 7 days after the patient uses a skin external preparation of the present invention. As can be seen from the figure, the abraded wound surface of a patient is obviously improved after the patient uses the invention for 3 days, and the wound surface is well healed and basically has no scars after insisting on using the invention for 7 days.

Example 2

The bezoar cultured in vitro is superfine ground into 600 mesh fine powder, can be directly used for external application on skin, is easier to absorb, and has better effect.

The external skin medicament is prepared by cultivating bezoar in vitro, taking the bezoar with the effects of clearing heat and removing toxicity and enhancing the transdermal absorption effect of the medicament, promoting tissue regeneration of a sore without leaving scars, and has special effects of simple and special medicament, is mainly externally used for treating various wound healing and repairing, including but not limited to bedsores, herpes zoster, various sores and ulcers and other skin diseases, and is used for promoting tissue regeneration and healing sores. Can also be used for treating skin wound and wound bleeding, disunion of wound, tissue ulceration and necrosis, infection and suppuration, etc. caused by operation.

Claims

1. An external skin medicine is characterized by comprising in-vitro cultured bezoar powder.

2. A method for preparing skin external medicine is characterized in that the bezoar cultured in vitro is micronized into 600 mesh fine powder to obtain the medicine.

3. A topical skin preparation is used for healing wound.

4. A topical skin preparation according to claim 3 for the treatment of bedsores, herpes zoster or sores.

5. A skin external preparation according to claim 3, for treating bleeding, non-healing of wound, ulceration, necrosis of tissue or suppuration due to surgical operation.