CN112218863A - O-糖蛋白-2-乙酰氨基-2-脱氧-3-d-吡喃糖苷酶抑制剂 - Google Patents

O-糖蛋白-2-乙酰氨基-2-脱氧-3-d-吡喃糖苷酶抑制剂 Download PDF

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Publication number
CN112218863A
CN112218863A CN201980019170.5A CN201980019170A CN112218863A CN 112218863 A CN112218863 A CN 112218863A CN 201980019170 A CN201980019170 A CN 201980019170A CN 112218863 A CN112218863 A CN 112218863A
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CN
China
Prior art keywords
compound
optionally substituted
pharmaceutically acceptable
acceptable salt
methyl
Prior art date
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Pending
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CN201980019170.5A
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English (en)
Chinese (zh)
Inventor
N.杰农
K.M.古基恩
J.维塞尔斯
L.张
R.吉亚纳塔西奥
E.Y.S.林
Z.辛
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Biogen Inc
Biogen MA Inc
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Biogen MA Inc
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Publication date
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Publication of CN112218863A publication Critical patent/CN112218863A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN201980019170.5A 2018-03-14 2019-03-13 O-糖蛋白-2-乙酰氨基-2-脱氧-3-d-吡喃糖苷酶抑制剂 Pending CN112218863A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862642932P 2018-03-14 2018-03-14
US62/642,932 2018-03-14
US201862690536P 2018-06-27 2018-06-27
US62/690,536 2018-06-27
US201862699443P 2018-07-17 2018-07-17
US62/699,443 2018-07-17
PCT/US2019/021995 WO2019178191A1 (en) 2018-03-14 2019-03-13 O-glycoprotein-2-acetamido-2-deoxy-3-d-glycopyranosidase inhibitors

Publications (1)

Publication Number Publication Date
CN112218863A true CN112218863A (zh) 2021-01-12

Family

ID=65952097

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980019170.5A Pending CN112218863A (zh) 2018-03-14 2019-03-13 O-糖蛋白-2-乙酰氨基-2-脱氧-3-d-吡喃糖苷酶抑制剂

Country Status (10)

Country Link
US (1) US20230117898A1 (ja)
EP (2) EP3765458B1 (ja)
JP (1) JP7453916B2 (ja)
CN (1) CN112218863A (ja)
AU (1) AU2019234759A1 (ja)
CA (1) CA3093315A1 (ja)
ES (1) ES2942211T3 (ja)
MA (1) MA52004A (ja)
MX (1) MX2020009530A (ja)
WO (1) WO2019178191A1 (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114213315A (zh) * 2021-12-31 2022-03-22 上海陶术生物科技有限公司 含氮杂环类化合物及其中间体的合成方法
CN114560805A (zh) * 2022-01-20 2022-05-31 上海陶术生物科技有限公司 含氮杂环化合物及其中间体的合成方法

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3585790A1 (en) * 2017-02-27 2020-01-01 Janssen Pharmaceutica NV [1,2,4]-triazolo [1,5-a]-pyrimidinyl derivatives substituted with piperidine, morpholine or piperazine as oga inhibitors
SG11202102379XA (en) * 2018-09-19 2021-04-29 Biogen Ma Inc O-glycoprotein-2-acetamido-2-deoxy-3-d-glucopyranosidase inhibitors
WO2021094312A1 (en) 2019-11-11 2021-05-20 Janssen Pharmaceutica Nv Pyrrolidine and bicycloheteroaryl containing oga inhibitor compounds
WO2021110656A1 (en) 2019-12-02 2021-06-10 Janssen Pharmaceutica Nv Oga inhibitor compounds
WO2021123291A1 (en) 2019-12-18 2021-06-24 Janssen Pharmaceutica Nv Oga inhibitor compounds
JP2023507184A (ja) 2019-12-18 2023-02-21 ヤンセン ファーマシューティカ エヌ．ベー． Ｏｇａ阻害剤化合物
WO2021123297A1 (en) 2019-12-18 2021-06-24 Janssen Pharmaceutica Nv Oga inhibitor compounds
KR102533471B1 (ko) * 2020-11-23 2023-05-19 (주) 메디프론디비티 O-GlcNAcase 저해 활성을 갖는 화합물 및 이의 용도

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105143222A (zh) * 2013-03-14 2015-12-09 默克专利有限公司 糖苷酶抑制剂
WO2017106254A1 (en) * 2015-12-18 2017-06-22 Merck Sharp & Dohme Corp. Glycosidase inhibitors and uses thereof
CN110300752A (zh) * 2016-12-16 2019-10-01 詹森药业有限公司 单环oga抑制剂化合物
CN110312716A (zh) * 2016-12-16 2019-10-08 詹森药业有限公司 双环oga抑制剂化合物
CN110325535A (zh) * 2017-02-27 2019-10-11 詹森药业有限公司 经哌啶、吗啉或哌嗪取代的作为oga抑制剂的[1,2,4]-三唑[1,5-a]-嘧啶基衍生物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4938949A (en) 1988-09-12 1990-07-03 University Of New York Treatment of damaged bone marrow and dosage units therefor
US9206128B2 (en) 2011-11-18 2015-12-08 Constellation Pharmaceuticals, Inc. Modulators of methyl modifying enzymes, compositions and uses thereof
EP2780013A4 (en) 2011-11-18 2015-07-01 Constellation Pharmaceuticals Inc MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF
WO2013078320A1 (en) 2011-11-21 2013-05-30 Constellation Pharmaceuticals Modulators of methyl modifying enzymes, compositions and uses thereof
WO2014124418A1 (en) 2013-02-11 2014-08-14 Constellation Pharmaceuticals, Inc. Modulators of methyl modifying enzymes, compositions and uses thereof
US9085583B2 (en) 2012-02-10 2015-07-21 Constellation—Pharmaceuticals, Inc. Modulators of methyl modifying enzymes, compositions and uses thereof
US9745305B2 (en) 2013-03-15 2017-08-29 Constellation Pharmaceuticals, Inc. Modulators of methyl modifying enzymes, compositions and uses thereof
US9969716B2 (en) 2013-08-15 2018-05-15 Constellation Pharmaceuticals, Inc. Indole derivatives as modulators of methyl modifying enzymes, compositions and uses thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105143222A (zh) * 2013-03-14 2015-12-09 默克专利有限公司 糖苷酶抑制剂
WO2017106254A1 (en) * 2015-12-18 2017-06-22 Merck Sharp & Dohme Corp. Glycosidase inhibitors and uses thereof
CN110300752A (zh) * 2016-12-16 2019-10-01 詹森药业有限公司 单环oga抑制剂化合物
CN110312716A (zh) * 2016-12-16 2019-10-08 詹森药业有限公司 双环oga抑制剂化合物
CN110325535A (zh) * 2017-02-27 2019-10-11 詹森药业有限公司 经哌啶、吗啉或哌嗪取代的作为oga抑制剂的[1,2,4]-三唑[1,5-a]-嘧啶基衍生物

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114213315A (zh) * 2021-12-31 2022-03-22 上海陶术生物科技有限公司 含氮杂环类化合物及其中间体的合成方法
CN114560805A (zh) * 2022-01-20 2022-05-31 上海陶术生物科技有限公司 含氮杂环化合物及其中间体的合成方法

Also Published As

Publication number Publication date
EP3765458B1 (en) 2023-01-11
WO2019178191A8 (en) 2019-11-21
MX2020009530A (es) 2021-01-15
CA3093315A1 (en) 2019-09-19
JP7453916B2 (ja) 2024-03-21
US20230117898A1 (en) 2023-04-20
MA52004A (fr) 2021-01-20
ES2942211T3 (es) 2023-05-30
EP4186899A1 (en) 2023-05-31
WO2019178191A1 (en) 2019-09-19
EP3765458A1 (en) 2021-01-20
AU2019234759A1 (en) 2020-09-17
JP2021518340A (ja) 2021-08-02

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