CN112168972A - 使用pde7抑制剂治疗成瘾和冲动控制障碍 - Google Patents

使用pde7抑制剂治疗成瘾和冲动控制障碍 Download PDF

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Publication number
CN112168972A
CN112168972A CN202011054538.2A CN202011054538A CN112168972A CN 112168972 A CN112168972 A CN 112168972A CN 202011054538 A CN202011054538 A CN 202011054538A CN 112168972 A CN112168972 A CN 112168972A
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CN
China
Prior art keywords
formula
alkyl
substituted
pde7
addiction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202011054538.2A
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English (en)
Chinese (zh)
Inventor
G·A·德莫普罗斯
G·A·盖塔纳里斯
R·奇科乔波
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Omeros Corp
Original Assignee
Omeros Medical Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US13/835,607 external-priority patent/US9220715B2/en
Application filed by Omeros Medical Systems Inc filed Critical Omeros Medical Systems Inc
Publication of CN112168972A publication Critical patent/CN112168972A/zh
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32Alcohol-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34Tobacco-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36Opioid-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Addiction (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN202011054538.2A 2012-05-07 2013-05-07 使用pde7抑制剂治疗成瘾和冲动控制障碍 Pending CN112168972A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261643611P 2012-05-07 2012-05-07
US61/643611 2012-05-07
US13/835,607 US9220715B2 (en) 2010-11-08 2013-03-15 Treatment of addiction and impulse-control disorders using PDE7 inhibitors
US13/835607 2013-03-15
CN201380036048.1A CN104768556A (zh) 2012-05-07 2013-05-07 使用pde7抑制剂治疗成瘾和冲动控制障碍

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201380036048.1A Division CN104768556A (zh) 2012-05-07 2013-05-07 使用pde7抑制剂治疗成瘾和冲动控制障碍

Publications (1)

Publication Number Publication Date
CN112168972A true CN112168972A (zh) 2021-01-05

Family

ID=49624481

Family Applications (3)

Application Number Title Priority Date Filing Date
CN202011054538.2A Pending CN112168972A (zh) 2012-05-07 2013-05-07 使用pde7抑制剂治疗成瘾和冲动控制障碍
CN201380036048.1A Pending CN104768556A (zh) 2012-05-07 2013-05-07 使用pde7抑制剂治疗成瘾和冲动控制障碍
CN202210569437.1A Pending CN114984229A (zh) 2012-05-07 2013-05-07 使用pde7抑制剂治疗成瘾和冲动控制障碍

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN201380036048.1A Pending CN104768556A (zh) 2012-05-07 2013-05-07 使用pde7抑制剂治疗成瘾和冲动控制障碍
CN202210569437.1A Pending CN114984229A (zh) 2012-05-07 2013-05-07 使用pde7抑制剂治疗成瘾和冲动控制障碍

Country Status (10)

Country Link
EP (1) EP2846805B1 (enExample)
JP (1) JP2015521177A (enExample)
CN (3) CN112168972A (enExample)
AU (1) AU2013266793B2 (enExample)
CA (1) CA2871151C (enExample)
IN (1) IN2014DN10404A (enExample)
PL (1) PL2846805T3 (enExample)
RS (1) RS58381B1 (enExample)
SI (1) SI2846805T1 (enExample)
WO (1) WO2013176877A2 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9220715B2 (en) 2010-11-08 2015-12-29 Omeros Corporation Treatment of addiction and impulse-control disorders using PDE7 inhibitors
KR20130124333A (ko) 2010-11-08 2013-11-13 오메로스 코포레이션 Pde7 억제제를 사용한 중독 및 충동-조절 장애의 치료
RU2019108464A (ru) 2016-08-26 2020-09-28 Мицубиси Танабе Фарма Корпорейшн Бициклическое азотсодержащее гетероциклическое соединение
EP4541372A1 (en) * 2022-06-15 2025-04-23 Shinichi Matsumoto Drug therapy for obsessive-compulsive disorder targeting dopamine d1 signal in striatal striosomes
AU2023326563A1 (en) * 2022-08-18 2025-02-27 Mitodicure Gmbh Use of a therapeutic agent with phosphodiesterase-7 inhibitory activity for the treatment and prevention of diseases associated with chronic fatigue, exhaustion and/or exertional intolerance

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007038551A2 (en) * 2005-09-26 2007-04-05 Avigen, Inc. Use of ibudilast for treating drug and behavioral addictions
CN1976938A (zh) * 2004-07-01 2007-06-06 第一阿斯比奥制药株式会社 具有pde7抑制活性的噻吩并吡唑衍生物
CN101087778A (zh) * 2004-12-31 2007-12-12 辉瑞产品有限公司 芳香杂环化合物吡咯烷基衍生物磷酸二酯酶抑制剂

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008119057A2 (en) * 2007-03-27 2008-10-02 Omeros Corporation The use of pde7 inhibitors for the treatment of movement disorders
US8637528B2 (en) * 2007-03-27 2014-01-28 Omeros Corporation Use of PDE7 inhibitors for the treatment of movement disorders
US8426439B2 (en) * 2007-04-11 2013-04-23 Omeros Corporation Compositions and methods for prophylaxis and treatment of addictions
FR2943673B1 (fr) * 2009-03-27 2013-03-29 Sanofi Aventis Applications therapeutiques de derives de quinazolinedione
FR2944282B1 (fr) * 2009-04-09 2013-05-03 Sanofi Aventis Derives de quinazolinedione, leur preparation et leurs diverses applications therapeutiques
KR20130124333A (ko) * 2010-11-08 2013-11-13 오메로스 코포레이션 Pde7 억제제를 사용한 중독 및 충동-조절 장애의 치료

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1976938A (zh) * 2004-07-01 2007-06-06 第一阿斯比奥制药株式会社 具有pde7抑制活性的噻吩并吡唑衍生物
CN101087778A (zh) * 2004-12-31 2007-12-12 辉瑞产品有限公司 芳香杂环化合物吡咯烷基衍生物磷酸二酯酶抑制剂
WO2007038551A2 (en) * 2005-09-26 2007-04-05 Avigen, Inc. Use of ibudilast for treating drug and behavioral addictions

Also Published As

Publication number Publication date
WO2013176877A3 (en) 2015-06-18
SI2846805T1 (sl) 2019-04-30
RS58381B1 (sr) 2019-04-30
EP2846805A2 (en) 2015-03-18
EP2846805B1 (en) 2018-11-21
WO2013176877A2 (en) 2013-11-28
JP2015521177A (ja) 2015-07-27
CN114984229A (zh) 2022-09-02
AU2013266793A1 (en) 2014-11-27
EP2846805A4 (en) 2016-08-10
AU2013266793B2 (en) 2016-08-04
IN2014DN10404A (enExample) 2015-08-14
CN104768556A (zh) 2015-07-08
CA2871151C (en) 2019-03-26
PL2846805T3 (pl) 2019-05-31
CA2871151A1 (en) 2013-11-28

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Application publication date: 20210105